Kanemaru Kazunori
| Department of Medicine | Associate Professor |
Researcher Information
Field Of Study
Career
- Apr. 2021 - Present
Nihon University School of Medicine, Department of Physiology, Associate Professor - Apr. 2018 - Mar. 2021
Nihon University School of Medicine, Division of Cellular and Molecular Pharmacology, Associate Professor - Apr. 2019 - Sep. 2019
Hiroshima University, School of Integrated Arts and Sciences, Visiting Associate Professor - Apr. 2008 - Mar. 2018
The University of Tokyo, Graduate School of Medicine, Assistant Professor - Apr. 2006 - Mar. 2008
The University of Tokyo, Graduate School of Medicine, Postdoc
Research activity information
Paper
- Screening for novel RyR2 inhibitors by ER Ca2+monitoring
Mai Takenaka; Masami Kodama; Takashi Murayama; Mari Ishigami-Yuasa; Shuichi Mori; Ryosuke Ishida; Junji Suzuki; Kazunori Kanemaru; Masami Sugihara; Masamitsu Iino; Aya Miura; Hajime Nishio; Sachio Morimoto; Hiroyuki Kagechika; Takashi Sakurai; Nagomi Kurebayashi
Molecular Pharmacology, Sep. 2023 - Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells
Chika Takano; Masafumi Horie; Isamu Taiko; Quang Duy Trinh; Kazunori Kanemaru; Shihoko Komine-Aizawa; Satoshi Hayakawa; Toshio Miki
Stem Cell Reviews and Reports, Dec. 2022 - Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria
Isamu Taiko; Chika Takano; Masayuki Nomoto; Shingo Hayashida; Kazunori Kanemaru; Toshio Miki
Scientific Reports, Nov. 2022 - Anti‑tumor effects of perampanel in malignant glioma cells
Juri Tatsuoka; Emiko Sano; Yuya Hanashima; Chihiro Yagi; Shun Yamamuro; Koichiro Sumi; Hiroyuki Hara; Kazuhide Takada; Kazunori Kanemaru; Shihoko Komine‑Aizawa; Yoichi Katayama; Atsuo Yoshino
Oncology Letters, Oct. 2022 - Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
Nagomi Kurebayashi; Takashi Murayama; Ryosaku Ota; Junji Suzuki; Kazunori Kanemaru; Takuya Kobayashi; Seiko Ohno; Minoru Horie; Masamitsu Iino; Fumiyoshi Yamashita; Takashi Sakurai
Journal of General Physiology, Sep. 2022 - Ratio-metric measurement of intracellular calcium in visceral muscles via selective expression of a yellow cameleon calcium sensor
Chiho Takai; Naoko Iwata; Kazunori Kanemaru; Kenji F. Tanaka; Yao Yu; Satoshi Iino; Shinsuke Nakayama
Sensors and Actuators B: Chemical, Aug. 2022 - Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest‐derived multilineage cells
Shigehiro Abe; Atsushi Kaida; Kazunori Kanemaru; Keiichiro Nakazato; Naoko Yokomizo; Yutaka Kobayashi; Masahiko Miura; Toshio Miki; Chiaki Hidai; Hisataka Kitano; Tetsuya Yoda
Cell Proliferation, Jun. 2022 - EGF domain peptide of Developmentally regulated endothelial locus1 facilitates gene expression of extracellularly applied plasmid DNA
Hisataka Kitano; Kazunori Kanemaru; Toshio Miki; Chiaki Hidai
Biologicals, Jan. 2022, Refereed
Lead - Soluble factors released by dedifferentiated fat cells reduce the functional activity of iPS cell-derived cardiomyocytes.
Hirofumi Watanabe; Kazunori Kanemaru; Kazuhiro Hagikura; Taro Matsumoto; Mamoru Ayusawa; Ichiro Morioka
Cell biology international, Oct. 2020, Refereed - Red fluorescent CEPIA indicators for visualization of Ca2+ dynamics in mitochondria
Kazunori Kanemaru, Junji Suzuki, Isamu Taiko, Masamitsu Iino
Scientific Reports, Feb. 2020, Refereed, Not invited
Lead - Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics.
Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Mari Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Katsuji Oguchi, Takashi Sakurai, Masamitsu Iino
Journal of General Physiology, Jun. 2019, Refereed, Not invited - Inositol 1,4,5-trisphosphate receptor type 2-independent Ca2+ release from the endoplasmic reticulum in astrocytes.
Okubo, Y; Kanemaru, K; Suzuki, J; Kobayashi, K; Hirose, K; Iino, M
Glia, 2019, Refereed, Not invited - Role of endoplasmic reticulum-mediated Ca2+ signaling in neuronal cell death.
Okubo; Y.; Mikami; Y.; Kanemaru; K. and Iino; M.
Antioxidant Redox Signaling, 2018, Refereed, Not invited - Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels.
Murayama, T; Kurebayashi, N; Ishigami-Yuasa, M; Mori, S; Suzuki, Y; Akima, R; Ogawa, H; Suzuki, J; Kanemaru, K; Oyamada, H; Kiuchi, Y; Iino, M; Kagechika, H; Sakurai, T
Molecular Pharmacology, 2018, Refereed, Not invited - Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel
Takashi Murayama; Nagomi Kurebayashi; Haruo Ogawa; Toshiko Yamazawa; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Katsuji Oguchi; Masamitsu Iino; Takashi Sakurai
HUMAN MUTATION, Nov. 2016, Refereed, Not invited - Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death
Yoshinori Mikami; Kazunori Kanemaru; Yohei Okubo; Takuya Nakaune; Junji Suzuki; Kazuki Shibata; Hiroki Sugiyama; Ryuta Koyama; Takashi Murayama; Akihiro Ito; Toshiko Yamazawa; Yuji Ikegaya; Takashi Sakurai; Nobuhito Saito; Sho Kakizawa; Masamitsu Iino
EBIOMEDICINE, Sep. 2016, Refereed, Not invited - Genetically Encoded Fluorescent Indicators for Organellar Calcium Imaging
Junji Suzuki; Kazunori Kanemaru; Masamitsu Iino
BIOPHYSICAL JOURNAL, Sep. 2016, Refereed, Not invited - Whisker experience-dependent mGluR signaling maintains synaptic strength in the mouse adolescent cortex
Jun Kubota; Yoshinori Mikami; Kazunori Kanemaru; Hiroshi Sekiya; Yohei Okubo; Masamitsu Iino
EUROPEAN JOURNAL OF NEUROSCIENCE, Aug. 2016, Refereed, Not invited - Visualization of Ca2+ Filling Mechanisms upon Synaptic Inputs in the Endoplasmic Reticulum of Cerebellar Purkinje Cells
Yohei Okubo; Junji Suzuki; Kazunori Kanemaru; Naotoshi Nakamura; Tatsuo Shibata; Masamitsu Iino
JOURNAL OF NEUROSCIENCE, Dec. 2015, Refereed, Not invited - Neuronal Regulation of Schwann Cell Mitochondrial Ca2+ Signaling during Myelination
Daisuke Ino; Hiroshi Sagara; Junji Suzuki; Kazunori Kanemaru; Yohei Okubo; Masamitsu Iino
CELL REPORTS, Sep. 2015, Refereed, Not invited - Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region
Takashi Murayama; Nagomi Kurebayashi; Toshiko Yamazawa; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Katsuji Oguchi; Masamitsu Iino; Takashi Sakurai
PLOS ONE, Jun. 2015, Refereed, Not invited - In Vivo Visualization of Subtle, Transient, and Local Activity of Astrocytes Using an Ultrasensitive Ca2+ Indicator
Kazunori Kanemaru; Hiroshi Sekiya; Ming Xu; Kaname Satoh; Nami Kitajima; Keitaro Yoshida; Yohei Okubo; Takuya Sasaki; Satoru Moritoh; Hidetoshi Hasuwa; Masaru Mimura; Kazuki Horikawa; Ko Matsui; Takeharu Nagai; Masamitsu Iino; Kenji F. Tanaka
CELL REPORTS, Jul. 2014, Refereed, Not invited - Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
Junji Suzuki; Kazunori Kanemaru; Kuniaki Ishii; Masamichi Ohkura; Yohei Okubo; Masamitsu Iino
NATURE COMMUNICATIONS, Jun. 2014, Refereed, Not invited - Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury
Kazunori Kanemaru; Jun Kubota; Hiroshi Sekiya; Kenzo Hirose; Yohei Okubo; Masamitsu Iino
Proceedings of the National Academy of Sciences of the United States of America, Jul. 2013, Refereed, Not invited - Imaging of Ca2+ and related signaling molecules and investigation of their functions in the brain
Yohei Okubo; Kazunori Kanemaru; Masamitsu Iino
Antioxidants and Redox Signaling, Apr. 2011, Refereed, Not invited - Imaging of Ca2+ and related signaling molecules and investigation of their functions in the brain.
Okubo Y; Kanemaru K; Iino M.
Antioxidant Redox Signaling, 2011, Refereed, Not invited - Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes
Kazunori Kanemaru; Jun Kubota; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Refereed, Not invited - Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes
Kazunori Kanemaru; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
JOURNAL OF NEUROSCIENCE, Aug. 2007, Refereed, Not invited - Solution structure of ADO1, a toxin extracted from the saliva of the assassin bug, Agriosphodrus dohrni
C Bernard; G Corzo; S Adachi-Akahane; G Foures; K Kanemaru; Y Furukawa; T Nakajima; H Darbon
PROTEINS-STRUCTURE FUNCTION AND GENETICS, Feb. 2004, Refereed, Not invited - Distribution of the Aplysia cardioexcitatory peptide, NdWFamide, in the central and peripheral nervous systems of Aplysia
F Morishita; Y Nakanishi; K Sasaki; K Kanemaru; Y Furukawa; O Matsushima
CELL AND TISSUE RESEARCH, Apr. 2003, Refereed, Not invited - Aplysia cardioactive peptide (NdWFamide) enhances the L-type Ca2+ current of Aplysia ventricular myocytes
Kazunori Kanemaru; Fumihiro Morishita; Osamu Matsushima; Yasuo Furukawa
Peptides, Nov. 2002, Refereed - Aplysia cardioactive peptide (NdWFamide) enhances the L-type Ca2+ current of Aplysia ventricular myocytes
K Kanemaru; F Morishita; O Matsushima; Y Furukawa
PEPTIDES, Nov. 2002, Refereed, Not invited - NdWFamide: A novel excitatory peptide involved in cardiovascular regulation of Aplysia
Fumihiro Morishita; Kosei Sasaki; Kazunori Kanemaru; Yuka Nakanishi; Osamu Matsushima; Yasuo Furukawa
Peptides, 2001, Refereed, Not invited
MISC
- Molecular Dynamics and Ca2+ Imaging of Mutant Type 1 Ryanodine Receptor
Toshiko Yamazawa; Haruo Ogawa; Takashi Murayama; Maki Yamaguchi; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kanemaru Kazunori; Takashi Sakurai; Masamitsu Iino
BIOPHYSICAL JOURNAL, Feb. 2020 - Investigation of Mutant Ryanodine Receptor Channel Activity using Functional Analysis and Molecular Dynamics
Toshiko Yamazawa; Haruo Ogawa; Maki Yamaguchi; Takashi Murayama; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kazunori Kanemaru; Takashi Sakurai; Iino Masamitsu
BIOPHYSICAL JOURNAL, Feb. 2019 - 小胞体内Ca2+濃度測定を利用した新規RyR1阻害薬のハイスループットスクリーニング
村山 尚; 呉林 なごみ; 湯浅 磨里; 石上; 森 修一; 鈴木 志奈; 秋間 龍之介; 小川 治夫; 鈴木 純二; 金丸 和典; 小山田 英人; 木内 祐二; 飯野 正光; 影近 弘之; 櫻井 隆
日本筋学会学術集会プログラム・抄録集, Aug. 2018, Not refereed, Not invited - 悪性高熱症関連変異を有する骨格筋型リアノジン受容体の構造と機能変化
山澤 徳志子; 山口 眞紀; 小川 治夫; 村山 尚; 小山田 英人; 呉林 なごみ; 鈴木 純二; 金丸 和典; 櫻井 隆; 飯野 正光
日本筋学会学術集会プログラム・抄録集, Aug. 2018, Not refereed, Not invited - Regulation of Store Ca2+ Level in HEK293 Cells Expressing Type 2 Ryanodine Receptor (RyR2) with CPVT Mutations
Kurebayashi Nagomi; Murayama Takashi; Ohta Ryosaku; Yamashita Fumiyoshi; Suzuki Junji; Kanemaru Kazunori; Iino Masamitsu; Sakurai Takashi
BIOPHYSICAL JOURNAL, 02 Feb. 2018, Not refereed, Not invited - Search for Type 2 Ryanodine Receptor Inhibitor by Monitoring Endoplasmic Reticulum Ca2+
Tamura Mai; Kurebayashi Nagomi; Murayama Takashi; Mori Shuichi; Ishigami-Yuasa Mari; Kagechika Hiroyuki; Suzuki Junji; Kanemaru Kazunori; Iino Masamitsu; Sakurai Takashi
BIOPHYSICAL JOURNAL, 02 Feb. 2018, Not refereed, Not invited - カルシウムイメージングによるアストロサイト機能解析（受賞講演総説）
金丸和典
日本薬理学雑誌, 2018, Not refereed, Invited - Visualization of Ca2+ dynamics within the endoplasmic reticulum for the investigation of neuronal and astrocytic functions
Okubo Yohei; Suzuki Junji; Kanemaru Kazunori; Nakamura Naotoshi; Shibata Tatsuo; Lino Masamitsu
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, Refereed, Not invited - Intra-organellar Ca2+ Signaling Imaged Using Genetically Encoded Ca2+ Indicators CEPIA
Suzuki Junji; Kanemaru Kazunori; Ishii Kuniaki; Ohkura Masamichi; Okubo Yohei; Iino Masamitsu
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, Refereed, Not invited - In vivo imaging of cerebral extracellular ATP dynamics
Kenji Takikawa; Hiroshi Sekiya; Kaname Satoh; Miki Takagi; Nami Kitajima; Kazunori Kanemaru; Hirokazu Sakamoto; Shigeyuki Namiki; Toshiko Yamazawa; Kenji Tanaka; Kenzo Hirose; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - S-nitrosylation of the type 1 ryanodine receptor mediates neuronal cell death
Yoshinori Mikami; Kazunori Kanemaru; Yasuhiro Oda; Sho Kakizawa; Kazuki Shibata; Hiroki Sugiyama; Ryuta Koyama; Akihiro Ito; Takashi Murayama; Toshiko Yamazawa; Masahiko Watanabe; Yuji Ikegaya; Nobuhito Saito; Takashi Sakurai; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - Alterations in neuronal mitochondrial functions in response to nitric oxide-induced Ca2+ release via type 1 ryanodine receptor
Takuya Nakaune; Junji Suzuki; Yoshinori Mikami; Kazunori Kanemaru; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - Comparison of Ca2+ release properties of RyR2 mutations causing catecholaminergic polymorphic ventricular tachycardia versus idiopathic ventricular fibrillation
Kurebayashi Nagomi; Murayama Takashi; Ohta Ryosaku; Yamashita Fumiyoshi; Suzuki Junji; Kanemaru Kazunori; Iino Masamitsu; Sakurai Takashi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, Not refereed, Not invited - Correlation of Molecular Dynamics Analysis and Calcium Signaling in Mutant Ryanodine Receptors
Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kazunori Kanemaru; Maki Yamaguchi; Chikara Sato; Masamitsu Iino
BIOPHYSICAL JOURNAL, Feb. 2016, Not refereed, Not invited - Characterization of Ca2+ - Induced Ca2+ Release via RyR2 Carrying Arrhythmogenic Mutations
Nagomi Kurebayashi; Takashi Murayama; Junji Suzuki; Kazunori Kanemaru; Masamitsu Iino; Takashi Sakurai
BIOPHYSICAL JOURNAL, Feb. 2016, Not refereed, Not invited - 成熟マウス大脳皮質におけるmGluRを介した経験依存性シナプス維持機構
大久保洋平; 久保田淳; 三上義礼; 三上義礼; 金丸和典; 関谷敬; 飯野正光; 飯野正光
日本薬理学会関東部会プログラム・要旨集, 2016 - 一酸化窒素は1型リアノジン受容体のS-ニトロシル化修飾を介して神経細胞死を誘導する
三上義礼; 三上義礼; 金丸和典; 大久保洋平; 中畝拓哉; 鈴木純二; 柿澤昌; 村山尚; 柴田和輝; 小山隆太; 伊藤明博; 山澤徳志子; 伊藤雅方; 冨田太一郎; 村上慎吾; 赤羽悟美; 櫻井隆; 池谷裕二; 齊藤延人; 飯野正光; 飯野正光
日本分子生物学会年会プログラム・要旨集(Web), 2016 - Ca2+シグナルから解明するアストロサイト機能
金丸和典
生化学, 2016, Not refereed, Invited - 高感度Ca2+指示タンパク質YC-Nano50発現マウスを用いた生体内アストロサイトの活動解析
金丸和典
日本薬理学雑誌, 2016, Not refereed, Invited - 高感度Ca²⁺指示タンパク質を用いた生体内アストロサイト活動の可視化解析 (特集 グリア研究の最先端) -- (グリア機能の基礎研究)
金丸 和典; 飯野 正光
生体の科学, Nov. 2015 - Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
Suzuki Junji; Kanemaru Kazunori; Ishii Kuniaki; Ohkura Masamichi; Okubo Yohei; Iino Masamitsu
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Refereed, Not invited - In vivo Ca2+ imaging of cortical astrocytes during ischemia using a mouse thromboembolic disease model
Miki Takagi; Hiroshi Sekiya; Nami Kitajima; Toshiko Yamazawa; Kazunori Kanemaru; Kenji Tanaka; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015 - Nitric oxide induces neuronal cell death by activation of RyR1 through S-nitrosylation
Yoshinori Mikami; Kazunori Kanemaru; Yasuhiro Oda; Sho Kakizawa; Hiroki Sugiyama; Kazuki Shibata; Ryuta Koyama; Akihiro Ito; Toshiko Yamazawa; Masahiko Watanabe; Yuji Ikagaya; Nobuto Saito; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015 - Effects of Arrhythmogenic Mutations on Ca2+-Induced Ca2+ Release Activities of Type 2 Ryanodine Receptors
Kurebayashi Nagomi; Murayama Takashi; Suzuki Junji; Kanemaru Kazunori; Iino Masamitsu; Sakurai Takashi
BIOPHYSICAL JOURNAL, 27 Jan. 2015, Not refereed, Not invited - Effects of MH and CCD Mutations in the Central Region on RyR1 Channels
Takashi Murayama; Nagomi Kurebayashi; Toshiko Yamazawa; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Katsuji Oguchi; Masamitsu Iino; Takashi Sakurai
BIOPHYSICAL JOURNAL, Jan. 2015, Not refereed, Not invited - FUNCTIONAL ANALYSIS OF RYANODINE RECEPTOR CARRYING MALIGNANT HYPERTHERMIA ASSOCIATED MUTATIONS
T. Yamazawa; T. Murayama; H. Oyamada; J. Suzuki; N. Kurebayashi; K. Kanemaru; K. Oguchi; T. Sakurai; S. Takemori; M. Iino
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, Jul. 2014, Not refereed, Not invited - Calcium-dependent N-cadherin upregulation mediates reactive astrogliosis and neuroprotection after brain injury
Kazunori Kanemaru; Jun Kubota; Hiroshi Sekiya; Kenzo Hirose; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - 1型リアノジン受容体のS-ニトロシル化を介した神経細胞死の誘導
三上義礼; 金丸和典; 小田康弘; 杉山弘樹; 小山隆太; 伊藤明博; 柿澤昌; 山澤徳志子; 村山尚; 渡辺雅彦; 斉藤延人; 飯野正光
日本薬理学会関東部会プログラム・要旨集, 2014 - Analysis of Ca2+ dynamics in the endoplasmic reticulum and mitochondria in pancreatic beta-cells
Tsubasa Nishikawa; Junji Suzuki; Kazunori Kanemaru; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Ca2+ release properties of arrhythmogenic ryanodine receptor type 2 mutants
Nagomi Kurebayashi; Takashi Murayama; Junji Suzuki; Kazunori Kanemaru; Masamitsu Iino; Takashi Sakurai
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - In vivo Ca2+ imaging of vascular smooth muscle cells in cerebral cortex
Nami Kitajima; Hiroshi Sekiya; Kazunori Kanemaru; Kenji Tanaka; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Imaging of Ca2+ dynamics within the endoplasmic reticulum and mitochondria using new GFP-based fluorescent Ca2+ indicators
Junji Suzuki; Kazunori Kanemaru; Kuniaki Ishii; Masamichi Ohkura; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Functional Analysis of Ryanodine Receptor Carrying Malignant Hyperthermia Associated Mutations
Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Nagomi Kurebayashi; Shigeru Takemori; Masamitsu Iino
BIOPHYSICAL JOURNAL, Jan. 2014, Not refereed, Not invited - Imaging of activity-dependent Ca2+ dynamics in the endoplasmic reticulum of Purkinje cells
Yohei Okubo; Junji Suzuki; Kazunori Kanemaru; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Functional analysis of type 1 ryanodine receptor carrying N-terminal malignant hyperthermia associated mutations
Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Nagomi Kurebayashi; Katsuji Oguchi; Takashi Sakurai; Shigeru Takemoril; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Mitochondrial calcium signaling in Schwann cells mediates myelination in the peripheral nervous system
Daisuke Ino; Hiroshi Sagara; Junji Suzuki; Kazunori Kanemaru; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Disease-associated mutations at the N-terminal region on the RyR1 divergently affect the calcium channel activity
Takashi Murayama; Nagomi Kurebayashi; Toshiko Yamazawa; Hideto Oyamada; Junji Suzuku; Kazunori Kanemaru; Shigeru Takemori; Katsuji Oguchi; Masamitsu Iino; Takashi Sakurai
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Induction of neuronal cell death through S-nitrosylation of the type 1 ryanodine receptor
Yoshinori Mikami; Kazunori Kanemaru; Yasuhiro Oda; Akihiro Ito; Sho Kakizawa; Toshiko Yamazawa; Nobuhito Saito; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Experience-dependent regulation of synaptic functions in mature mouse barrel cortex
Jun Kubota; Kazunori Kanemaru; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Calcium-dependent N-cadherin upregulation mediates reactive astrogliosis and neuroprotection after brain injury
Kazunori Kanemaru; Jun Kubota; Hiroshi Sekiya; Kenzo Hirose; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not refereed, Not invited - Divergent effects of disease-associated mutations on type 1 ryanodine receptor channel
Takashi Murayama; Nagomi Kurebayashi; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Takashi Sakurai; Masamitsu Iino; Takashi Sakurai
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not refereed, Not invited - Imaging of Ca2+ dynamics within the endoplasmic reticulum using new fluorescent Ca2+ indicators
Junji Suzuki; Kazunori Kanemaru; Kuniaki Ishii; Masamichi Ohkura; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not refereed, Not invited - Ca2+-dependent regulation of N-cadherin expression level in astrocytes underlies reactive astrogliosis and neuroprotection upon brain injury
K. Kanemaru; J. Kubota; H. Sekiya; K. Hirose; Y. Okubo; M. Iino
JOURNAL OF NEUROCHEMISTRY, Oct. 2012, Not refereed, Not invited - Bidirectional roles of brain 2-arachidonoylglycerol in bombesin-induced activation of central sympatho-adrenomedullary outflow in rats
Daisuke Ino; Kazunori Kanemaru; Yohei Okubo; Kuniaki Ishii; Masamichi Ohkura; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not refereed, Not invited - Imaging of Ca2+ dynamics within the endoplasmic reticulum using a new fluorescent Ca2+ indicator
Junji Suzuki; Kazunori Kanemaru; Kuniaki Ishii; Masamichi Ohkura; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not refereed, Not invited - Ca2+-dependent translational control of N-cadherin in astrocytes underlies neuroprotection upon brain injury
Kazunori Kanemaru; Jun Kubota; Kenzo Hirose; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not refereed, Not invited - Axonal ATP signaling mediates Schwann cell myelination
Daisuke Ino; Kazunori Kanemaru; Yohei Okubo; Kuniaki Ishii; Masamichi Ohkura; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not refereed, Not invited - Pumilio 2 mediates Ca2+ signal-dependent maintenance of N-cadherin expression in astrocytes
Kazunori Kanemaru; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not refereed, Not invited - Calcium and pumilio 2-dependent regulation of N-cadherin expression underlies neuroprotection by reactive astrocytes
Kazunori Kanemaru; Jun Kubota; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
NEUROSCIENCE RESEARCH, 2011, Not refereed, Not invited - ATP-induced inositol 1,4,5-trisphosphate signaling in Schwann cells is required for myelination
Daisuke Ino; Kazunori Kanemaru; Yohei Okubo; Kuniaki Ishii; Masamichi Ohkura; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not refereed, Not invited - Imaging of Ca2+ dynamics within the endoplasmic reticulum using a new fluorescent Ca2+ indicator
Junji Suzuki; Kazunori Kanemaru; Kuniaki Ishii; Masamichi Ohkura; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not refereed, Not invited - Time-lapse imaging of individual lung cancer cells undergoing epithelial-mesenchymal transition
Naotoshi Nakamura; Kazunori Kanemaru; Toshiko Yamazawa; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not refereed, Not invited - 高感度Ca2+指示タンパク質を用いた生体内アストロサイト活動の可視化解析
金丸和典; 飯野正光
生体の科学, 2011, Not refereed, Invited - A novel translational regulator of Ca2+ signal-dependent maintenance of N-cadherin expression in astrocytes
Kazunori Kanemaru; Yohei Okubo; Kenzo Hirose; Masamitsu Lino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not refereed, Not invited - A novel translational regulator of Ca2+ signal-dependent maintenance of N-cadherin expression in astrocytes
Kazunori Kanemaru; Okubo Yohei; Kenzo Hirose; Masamitsu Iino
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited - Inositol 1,4,5-trisphosphate signaling in Schwann cells mediates the formation of myelin sheath
Daisuke Ino; Kazunori Kanemaru; Yohei Okubo; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not refereed, Not invited - The novel regulator of spontaneous Ca2+ oscillation-dependent maintenance of N-cadherin expression level in astrocytes
Kazunori Kanemaru; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
NEUROSCIENCE RESEARCH, 2009, Not refereed, Not invited - Regulation of astrocyte-dependent neurite growth by spontaneous Ca2+ oscillations in astrocytes
Kazunori Kanemaru; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, Not refereed, Not invited - Roles of spontaneous Ca2+ signals in astrocytes in neurite outgrowth
K Kanemaru; Y Okubo; K Hirose; M Iino
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not refereed, Not invited - Roles of spontaneous Ca2+ signals in astrocytes in neurite outgrowth
Kazunori Kanemaru; Yohei Okubo; Kenzo Hirose; Masamitsu Iino
NEUROSCIENCE RESEARCH, 2006, Not refereed, Not invited
Books and other publications
Lectures, oral presentations, etc.
- 細胞内カルシウム動態イメージングによる末梢臓器および組織の生理機能の解明
金丸和典
第101回日本生理学会大会, Mar. 2024, Not invited - Ca2+センサー発現マウスを用いた肝細胞のin vivo Ca2+動態解析
谷田部 一輝; 平岡 優一; 飯野 正光; 三木 敏生; 金丸 和典
第101回日本生理学会大会, Mar. 2024, Not invited - In vivo Ca2+ imaging analysis of pancreatic β-cells and liver hepatocytes using transgenic mouse lines expressing ratiometric Ca2+ sensor protein
金丸 和典; 太向 勇; 陳 開; 茂木 優貴; 平岡 優一; 三木 敏生; 飯野 正光
第97回日本薬理学会年会, Dec. 2023 - 神経変性疾患の人為制御を目指したアストロサイトCa2+活動の可視化解析
金丸和典
第46回 日本神経組織培養研究会, Dec. 2023, Invited - Analysis of macroscopic Ca2+ activity in cortical astrocytes in mouse models of neurodegenerative diseases
Kazunori KANEMARU; Yuki MOTEGI; Masamitsu IINO
THE 50th NAITO CONFERENCE - Glia World, Oct. 2023, Not invited - In vivo イメージングによる膵および肝臓細胞のカルシウム活動解析
金丸 和典; 谷田部 一輝; 太向 勇; 茂木 優貴; 平岡 優一; 三木 敏生; 飯野 正光
2022年度生理研研究会「細胞システム理解のためのシグナル応答原理解明の最前線」, Sep. 2023, Not invited - オルガネラのカルシウムセンサーの開発と生体内イメージングへの応用
金丸和典
日本生理学会 第100回記念大会, Mar. 2023 - 膵β細胞カルシウム活動のin vivo可視化により見えてきた自律神経制御と体内インスリン動態
金丸 和典
Systematic Integration of Molecular Brain Science, Feb. 2023, Invited - 【ワークショップオーガナイザー】4-B-W15: ワークショップ15（9:30～10:30）,熱・ホルモン・末梢臓器細胞内カルシウム動態のin vivoイメージングを可能とする新技術
第96回日本薬理学会年会, Dec. 2022 - 遺伝子改変マウス膵臓および肝臓細胞のin vivoカルシウムイメージング解析
第96回日本薬理学会年会, Dec. 2022 - 【座長】2-B-O02: 一般演題（口頭）（15:30～16:30）,生体内活性物質、細胞内情報伝達
第96回日本薬理学会年会, Dec. 2022, Invited - 膵β細胞におけるコリン作動性カルシウム抑制
太向 勇; 金丸 和典; 飯野 正光
第96回日本薬理学会年会, Dec. 2022 - In vivo カルシウムイメージングによるマウス生体内 β 細胞の活動様式解明
金丸 和典; 太向 勇; 陳 開; 茂木 優貴; 平岡 優一; 飯野 正光
2022 年度 生理学研究所研究会「細胞システム理解のためのシグナル応答原理解明の最前線」, Sep. 2022 - カルシウムセンサータンパク質発現マウスを用いた肝細胞カルシウム動態のin vivoイメージング解析
金丸和典
第29回肝細胞研究会, Aug. 2022 - マウスβ細胞カルシウム活動のin vivoイメージング解析
金丸和典
第８５回 Blood Vessel Club, Jul. 2022 - 膵β細胞におけるMICU1によるミトコンドリアカルシウムシグナルの制御
太向 勇、金丸 和典、飯野 正光
第95回日本薬理学会年会, Mar. 2022 - レシオ型Ca2+センサー発現マウスを用いた生体内β細胞におけるCa2+活動解析
金丸 和典、太向 勇、飯野 正光
第95回日本薬理学会年会, Mar. 2022 - 神経変性疾患モデルマウスにおけるアストロサイトCa2+活動の脳表イメージング解析
茂木 優貴、飯野 正光、金丸 和典
第95回 日本薬理学会年会, Mar. 2022 - In vivo imaging analysis of Ca2+ signaling in pancreatic β-cells with transgenic mice expressing ratiometric Ca2+ indicator
Kazunori Kanemaru; Isamu Taiko; Masamitsu Iino
The 94th Annual Meeting of the Japanese Pharmacological Society, Mar. 2021 - An in vivo macroscopic Ca2+ imaging method for analysis of astrocytic Ca2+ activities in neurodegenerative disease model mice
Yuki Motegi; Masamitsu Iino; Kazunori Kanemaru
The 94th Annual Meeting of the Japanese Pharmacological Society, Mar. 2021 - アストロサイトCa2+シグナルに制御される神経保護因子の探索
金丸和典
第39回日本認知症学会学術集会, Nov. 2020, Invited - 神経変性疾患におけるグリア細胞Ca2+活動解析を目指したマウス脳表in vivoイメージング実験法
茂木 優貴; 飯野 正光; 金丸 和典
第42回神経組織培養研究会, Nov. 2020 - 赤色蛍光CEPIAを用いたミトコンドリアCa2+動態の可視化解析
金丸 和典; 鈴木 純二; 太向 勇; 飯野 正光
第６３回日本神経化学会, Sep. 2020 - 高感度レシオ型Ca2+インジケーター発現マウスを用いた生体内β細胞と膵島のCa2+イメージング解析
金丸 和典; 太向 勇; 飯野 正光
第９３回日本薬理学会年会, Mar. 2020 - 膵β細胞におけるミトコンドリアカルシウムシグナルの制御
太向 勇; 金丸 和典; 飯野 正光
第９３回日本薬理学会年会, Mar. 2020, Not invited - Intracellular, intercellular and organellar Ca2+ imaging analysis for elucidation of cellular functions
Kazunori Kanemaru
NEW YEAR JOINT LAB MEETING Div. Microbiology of Nihon Univ. with Hanyang Univ. and Meikai Univ., Jan. 2020, Not invited - In vivoアストロサイトCa2+イメージング
Kazunori Kanemaru
第41回神経組織培養研究会, Nov. 2019, Invited - 細胞内カルシウムイメージングで明らかになってきたグリア・膵β細胞の活動様式とその機能
Kazunori Kanemaru
第106回生命科学セミナー, Sep. 2019, Invited - 生体イメージング・方法論・技術
第９２回日本薬理学会年会, Mar. 2019, Not invited - タンパク質型Ca2+インジケーター発現マウスを用いたβ細胞の生体内Ca2+イメージング解析
金丸 和典; 太向 勇; 飯野 正光
第９２回日本薬理学会年会, Mar. 2019, Not invited - カルシウム依存性神経保護因子のプロテオミクス解析
金丸和典
第２４回グリアクラブ, Feb. 2019, Not invited - 膵β細胞カルシウムシグナルの生体内イメージング解析
金丸和典
平成30年度生理研研究会「シグナル動態の可視化と操作に基づく多階層機能解析の新展開」, Sep. 2018, Not invited - オルガネラ局在型および細胞質局在型超高感度カルシウムインジケーターを用いたβ細胞カルシウムシグナル解析
金丸和典
第73回Blood Vessel Club, Jul. 2018, Not invited - 細胞分子薬理学部門の研究紹介
平成３０年度日本大学医学部基礎教育総医局会上半期情報交換会, Jul. 2018, Not invited - In vivo Ca2+ imaging analysis of β-cells using an ultrasensitive Ca2+ indicator YC-Nano50
Kanemaru Kazunori; Isamu Taiko; Nami Kitajima; Hiroshi Sekiya; Masamitsu Iino
WCP2018 KYOTO (18th WORLD CONGRESS of basic and clinical Pharmacology), Jul. 2018, Not invited - 高感度カルシウムインジケータータンパク質YC-Nano50を用いた膵β細胞の生体内イメージング解析
金丸 和典; 太向 勇; 北島 奈美; 関谷 敬; 飯野 正光
第138回日本薬理学会関東部会, Mar. 2018, Not invited - In vivo analysis of astrocytic calcium signaling
Kazunori Kanemaru; Hiroshi Sekiya; Yohei Okubo; Masamitsu Iino
第５回グリアアセンブリ国際シンポジウム「グリアアセンブリによる脳機能の発現と病態」, Jan. 2018, Not invited - カルシウムインジケーター発現マウスを用いた生体内β細胞カルシウムシグナル解析
金丸 和典; 太向 勇; 北島 奈美; 関谷 敬; 飯野 正光
第90回日本薬理学会年会, Mar. 2017, Not invited - カルシウムイメージングで切り拓くアストロサイト機能（日本薬理学会 学術奨励賞受賞講演）
金丸和典
第９０回日本薬理学会年会, Mar. 2017, Invited - オルガネラ内腔Ca2+インジケーターおよびCa2+インジケーター発現マウスを用いたβ細胞Ca2+シグナル解析
金丸 和典; 太向 勇; 北島 奈美; 関谷 敬; 飯野 正光
第１３５回日本薬理学会関東部会, Oct. 2016, Not invited - Calcium imaging method using YC-Nano50 for the visualization of subtle and local activity of astrocytes in vivo
Kazunori Kanemaru
2nd "Young Glia" meeting in Homburg, Germany: Japanese-German YoungGlia collaborative meeting for mutual research exchange, May 2016, Not invited - 超高感度カルシウムセンサーを発現するマウスを用いた生体内アストロサイトのイメージング解析
金丸 和典; 関谷 敬; 北島 奈美; 高木 美貴; 田中 謙二; 飯野 正光
第89回日本薬理学会年会, Mar. 2016, Not invited
Research Themes
- 生体内インスリン動態制御機構の新規in vivo肝・膵イメージング法による解明
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Apr. 2020 - Mar. 2023
金丸 和典 - 膵β細胞イメージングを基盤とする糖尿病の新規治療戦略創出
東京医科歯科大学 2021年度難治疾患共同研究拠点共同研究, Apr. 2021 - Mar. 2022 - 新規生体内β細胞 Ca2+イメージング法による生体内インスリン動態解析
公益財団法人ノバルティス科学振興財団, Apr. 2021 - Partnership to Realize Innovative Seeds and Medicines (PRISM) 若手研究者共創型
大日本住友製薬株式会社, Mar. 2020 - アストロサイト活動依存的な反応性グリオシス制御因子の探索
公益財団法人 武田科学振興財団, 2018 年医学系研究助成(精神・神経・脳領域), Nov. 2018
金丸和典 - 遺伝子改変マウスを用いた膵β細胞カルシウムシグナル時空間動態の生体内解析
公益財団法人 内藤記念科学振興財団, 第49回内藤記念科学奨励金・研究助成, Mar. 2018
金丸和典 - グリア細胞由来の神経細胞死制御因子の同定と解析
日本学術振興会, 科研費 若手研究(A), Apr. 2015 - Mar. 2017
金丸和典 - 生体内インスリン動態とその形成機構を遺伝子改変マウスの膵・肝 in vivo カルシウムイメージングから解き明かす
2022年度 武田科学振興財団 医学系研究助成 基礎, Aug. 2022 - May 2027
金丸和典 - マウス膵臓および肝臓のin vivoカルシウムイメージングによる生体内インスリン動態とその発生・制御機構の解明
2022年度 内藤記念科学奨励金・研究助成, Apr. 2023 - Mar. 2024
金丸和典 - Basis of treatment strategy for type 2 diabetes using new indices obtained by visualization of pancreatic beta cell activities in vivo
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Apr. 2020 - Mar. 2023
飯野 正光; 金丸 和典 - 脳損傷時アストロサイトのカルシウム活動依存的な神経保護因子の探索
The Pharmacological Research Foundation, Tokyo, 平成30年度研究助成, Sep. 2018 - Sep. 2019
金丸和典 - Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Nov. 2015 - Mar. 2018
IKENAKA Kazuhiro; ITO Kei; UEKI Takatoshi; OHKI Kenichi; KATO Takahiro; KANEMARU Kazunori; SHIMIZU Takeshi; TAKEBAYASHI Hirohide; TANAKA Kenji; HASHIOTO Kohichi; YAMAZAKI Yoshihiko; INOUE Kazuhide; OKABE Shigeo; OZAKI Norio; KANBA Shigenobu; KIRA Junichi; KOHSAKA Shinichi; FUKUYAMA Hidenao; BANNAI Hiroko; NAKASHIMA Kinichi; IMAI Hiroo; MATSUI Ko; TACHIKAWA Masanori; KAKEGAWA Wataru - カルシウムシグナルの可視化と制御によるグリアアセンブリ動態の解明
日本学術振興会, 新学術領域研究(研究領域提案型) グリアアセンブリによる脳機能発現の制御と病態, Jun. 2013 - Mar. 2018
飯野正光 - 中枢神経系ネットワークのカルシウム制御と病態生理機構
日本学術振興会, 科研費 基盤研究(S), May 2013 - Mar. 2018
飯野正光 - 中枢神経系細胞間ネットワークにおけるシグナル機構の可視化解析
日本学術振興会, 基盤研究(S), May 2009 - Mar. 2014
飯野正光 - アストロサイトのカルシウムシグナルにより発現制御される翻訳抑制因子の機能解明
日本学術振興会, 科研費 若手研究(B), Apr. 2010 - Mar. 2011
金丸和典 - 膵β細胞イメージングを基盤とする糖尿病の新規治療戦略創出
東京医科歯科大学 - 膵 β 細胞の生体内イメージング解析による糖尿病の治療戦略創生
東京医科歯科大学, 2020年度難治疾患共同研究拠点共同研究
