GOMI Hiroshi

College of Bioresource Sciences Department of Veterinary MedicineProfessor

Degree

  • Master of Agriculture, 東京大学, Mar. 1989
  • Doctor of Agriculture, 東京大学, Mar. 1992

Research Keyword

  • Neuroendocrine cells
  • グラニンタンパク質
  • ホルモン分泌
  • 下垂体
  • 膵島
  • アストロサイト
  • 副腎髄質
  • 唾液腺
  • ジーンターゲッティング
  • 開口放出
  • 小脳運動学習
  • Behavioral genetics
  • Gene targeting
  • Neuroglia
  • 系統解剖学

Field Of Study

  • Life sciences, Anatomy, General anatomy (including histology/embryology)
  • Life sciences, Metabolism and endocrinology
  • Life sciences, Animals: biochemistry, physiology, behavioral science, Integrative animal science
  • Life sciences, Neuroscience - general, General Neuroscience
  • Life sciences, Laboratory animal science, Integrative animal science
  • Life sciences, Veterinary medicine, Basic Veterinary Science/Basic Animal Science

Career

  • Apr. 2014 - Present
    日本大学生物資源科学部教授
  • Apr. 2011 - Mar. 2014
    日本大学生物資源科学部准教授
  • Apr. 2007 - Mar. 2011
    群馬大学生体調節研究所准教授
  • Apr. 2001 - Mar. 2007
    群馬大学生体調節研究所文部科学教官助教授
  • Jan. 1998 - Mar. 2001
    理化学研究所脳科学総合研究センター研究員
  • Apr. 1997 - Dec. 1997
    新潟大学脳研究所文部教官助手
  • Apr. 1996 - Mar. 1997
    日本学術振興会特別研究員 (南カリフォルニア大学神経科学博士研究員)
  • Aug. 1993 - Mar. 1996
    京都大学ウィルス研究所教務補佐員
  • Apr. 1993 - Jul. 1993
    京都大学ウィルス研究所研修員
  • Apr. 1992 - Mar. 1993
    農林水産省農林水産技官(獣医系技術職員)

Educational Background

  • Apr. 1989 - Mar. 1992
    The University of Tokyo, Graduate School, Division of Agricultural Science, Veterinary Science
  • Apr. 1987 - Mar. 1989
    東京大学, Graduate School, Division of Agricultural Science, Veterinary Science
  • Apr. 1983 - Mar. 1987
    Nihon University, Faculty of Agriculture and Veterinary Medicine, Veterinary Medicine

Member History

  • Apr. 2012 - Present
    評議員, 日本獣医学会
  • Dec. 2018 - Nov. 2019
    科学研究費委員会専門委員, 日本学術振興会
  • Sep. 2017 - Sep. 2019
    理事, 日本獣医解剖学会
  • Dec. 2016 - Nov. 2017
    科学研究費委員会専門委員, 日本学術振興会
  • Dec. 2013 - Nov. 2015
    科学研究費委員会専門委員, 日本学術振興会

Paper

  • ★Dominant expression of chromogranin B in pituitary corticotrophs and its putative role in interaction with secretogranin III
    Shota Kikuchi; Koki Odashima; Tadashi Yasui; Seiji Torii; Masahiro Hosaka; Hiroshi Gomi
    Journal of Histochemistry & Cytochemistry, Mar. 2025, Refereed, Not invited
    Last
  • ★Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
    Tadashi Yasui; Mutsumi Mashiko; Akihiro Obi; Hiroyuki Mori; Moeko Ito-Murata; Hiroki Hayakawa; Shota Kikuchi; Masahiro Hosaka; Chisato Kubota; Seiji Torii; Hiroshi Gomi
    Histochemistry and Cell Biology, Mar. 2024, Refereed
    Last
  • ★Phogrin regulates high-fat diet-induced compensatory pancreatic β-cell growth by switching binding partners
    Chisato Kubota; Ryoko Torii; Masahiro Hosaka; Toshiyuki Takeuchi; Hiroshi Gom; Seiji Torii
    Nutrients, Jan. 2024, Refereed
  • ★Differential expression of secretogranins II and III in canine adrenal chromaffin cells and pheochromocytomas
    Hiroshi Gomi; Takahiro Nagumo; Kazushi Asano; Makoto Konosu; Tadashi Yasui; Seiji Torii; Masahiro Hosaka
    Journal of Histochemistry & Cytochemistry, May 2022, Refereed
    Lead
  • ★Morphological and histochemical characterization of the secretory epithelium in the canine lacrimal gland
    Tadashi Yasui; Kenya Miyata; Chie Nakatsuka; Azuma Tsukise; Hiroshi Gomi
    European Journal of Histochemistry, Nov. 2021, Refereed, Not invited
    Last
  • ★Expression pattern of the LacZ reporter in secretogranin III gene-trapped mice
    Hiroshi Gomi; Airi Hinata; Tadashi Yasui; Seiji Torii; Masahiro Hosaka
    Journal of Histochemistry & Cytochemistry, Apr. 2021, Refereed, Not invited
    Lead
  • ★Impaired processing of prohormones in secretogranin III-null mice causes maladaptation to an inadequate diet and stress
    Yoshinori Maeda; Saki Kudo; Ken Tsushima; Eri Sato; Chisato Kubota; Aika Kayamori; Hiroki Bochimoto; Daisuke Koga; Seiji Torii; Hiroshi Gomi; Tsuyoshi Watanabe; Masahiro Hosaka
    Endocrinology, Feb. 2018, Refereed, Not invited
  • ★The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic cells
    Seiji Torii; Chisato Kubota; Naoya Saito; Ayumi Kawano; Ni Hou; Masaki Kobayashi; Ryoko Torii; Masahiro Hosaka; Tadahiro Kitamura; Toshiyuki Takeuchi; Hiroshi Gomi
    Journal of Biological Chemistry, 2018, Refereed, Not invited
    Last
  • ★Canine salivary glands: analysis of Rab and SNARE protein expression and SNARE complex formation with diverse tissue properties
    Hiroshi Gomi; Hiromi Osawa; Rie Uno; Tadashi Yasui; Masahiro Hosaka; Seiji Torii; Azuma Tsukise
    Journal of Histochemistry & Cytochemistry, Nov. 2017, Refereed, Not invited
    Lead
  • ★Expression of secretogranin III in chicken endocrine cells: its relevance to the secretory granule properties of peptide prohormone processing and bioactive amine content
    Hiroshi Gomi; Satomi Morikawa; Naoki Shinmura; Hiroaki Moki; Tadashi Yasui; Azuma Tsukise; Seiji Torii; Tsuyoshi Watanabe; Yoshinori Maeda; Masahiro Hosaka
    Journal of Histochemistry & Cytochemistry, May 2015, Refereed, Not invited
    Lead
  • ★Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells
    Hiroshi Gomi; Chisato Kubota-Murata; Tadashi Yasui; Azuma Tsukise; Seiji Torii
    Journal of Histochemistry & Cytochemistry, Feb. 2013, Refereed, Not invited
    Lead
  • ★Role of GFAP in morphological retention and distribution of reactive astrocytes induced by scrapie encephalopathy in mice
    Hiroshi Gomi; Takashi Yokoyama; Shigeyoshi Itohara
    Brain Research, Feb. 2010, Refereed, Not invited
    Lead
  • ★Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice
    Hiroshi Gomi; Takayuki Sassa; Richard F. Thompson; Shigeyoshi Itohara
    Frontiers in Behavioral Neuroscience, 2010, Refereed, Not invited
    Lead
  • ★Docking is not a prerequisite but a temporal constraint for fusion of secretory granules
    Kazuo Kasai; Takuji Fujita; Hiroshi Gomi; Tetsuro Izumi
    Traffic, Jul. 2008, Refereed, Not invited
  • ★Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane
    Hiroshi Gomi; Kenichi Mori; Shigeyoshi Itohara; Tetsuro Izumi
    Molecular Biology of the Cell, Nov. 2007, Refereed, Not invited
    Lead
  • ★Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance
    Tetsuro Izumi; Kazuo Kasai; Hiroshi Gomi
    Diabetes Obesity & Metabolism, Nov. 2007, Refereed, Not invited
  • ★Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice
    Naoki Otani; Hiroshi Nawashiro; Shinji Fukui; Hidetoshi Ooigawa; Atsushi Ohsumi; Terushige Toyooka; Katsuji Shima; Hiroshi Gomi; Michael Brenner
    Journal of Clinical Neuroscience, Nov. 2006, Refereed, Not invited
  • ★Granuphilin molecularly docks insulin granules to the fusion machinery
    Hiroshi Gomi; Shin Mizutani; Kazuo Kasai; Shigeyoshi Itohara; Tetsuro Izumi
    Journal of Cell Biology, Oct. 2005, Refereed, Not invited
    Lead
  • ★Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
    Kazuo Kasai; Mica Ohara-Imaizumi; Noriko Takahashi; Shin Mizutani; Shengli Zhao; Toshiteru Kikuta; Haruo Kasai; Shinya Nagamatsu; Hiroshi Gomi; Tetsuro Izumi
    Journal of Clinical Investigation, Feb. 2005, Refereed, Not invited
  • ★Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus
    *Takayuki Sassa; *Hiroshi Gomi; Shigeyoshi Itohara
    Cell and Tissue Research, Feb. 2004, Refereed, Not invited
    Lead
  • ★Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice
    Masaaki Takemura; Hiroshi Gomi; Emma Colucci-Guyon; Shigeyoshi Itohara
    Journal of Neuroscience, Aug. 2002, Refereed, Not invited
  • ★Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE
    Takayuki Sassa; Hiroshi Gomi; William Sun; Toshio Ikeda; Richard F Thompson; Shigeyoshi Itohara
    Journal of Neurochemistry, May 2000, Refereed, Not invited
  • ★Learning induces a CDC2-related protein kinase, KKIAMRE
    Hiroshi Gomi; William Sun; Caleb E Finch; Shigeyoshi Itohara; Kenji Yoshimi; Richard F Thompson
    Journal of Neuroscience, Nov. 1999, Refereed, Not invited
    Lead
  • ★Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice
    *Katsuei Shibuki; *Hiroshi Gomi; Lu Chen; Shaowen W Bao; Jeansok J Kim; Hidemitsu Wakatsuki; Toshiyuki Fujisaki; Kazushi Fujimoto; Akira Katoh; Toshio Ikeda; Chong Chen; Richard F Thompson; Shigeyoshi Itohara
    Neuron, Mar. 1996, Refereed, Not invited
    Lead
  • ★Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions
    Hiroshi Gomi; Takashi Yokoyama; Kazushi Fujimoto; Toshio Ikeda; Akira Katoh; Takeshi Itoh; Shigeyoshi Itohara
    Neuron, Jan. 1995, Refereed, Not invited
    Lead
  • ★Antioxidant enzymes in the brain of zitter rats: abnormal metabolism of oxygen species and its relevance to pathogenic changes in the brain of zitter rats with genetic spongiform encephalopathy
    Hiroshi Gomi; Ikuko Ueno; Kazuya Yamanouchi
    Brain Research, Aug. 1994, Refereed, Not invited
    Lead
  • ★Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in zitter rats
    Hiroshi Gomi; Toshio Ikeda; Tetsuo Kunieda; Shigeyoshi Itohara; Stanley B Prusiner; Kazuya Yamanouchi
    Neuroscience Letters, Jan. 1994, Refereed, Not invited
    Lead
  • ★Genetic spongiform encephalopathies - Reply
    Hiroshi Gomi; Yasuhiro Yoshikawa; Kazuya Yamanouchi
    Journal of Neuropathology and Experimental Neurology, Nov. 1990, Refereed, Not invited
    Lead
  • ★Edematous changes in the central nervous system of bitter rats with genetic spongiform encephalopathy
    Hiroshi Gomi; Kimimasa Inui; Hiroyuki Taniguchi; Yasuhiro Yoshikawa; Kazuya Yamanouchi
    Journal of Neuropathology and Experimental Neurology, May 1990, Refereed, Not invited
    Lead
  • Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes
    Eri Sato; Yoshinori Maeda; Yui Sato; Airi Hinata; Hiroshi Gomi; Daisuke Koga; Seiji Torii; Tsuyoshi Watanabe; Masahiro Hosaka
    Biochemical Journal, Mar. 2019, Refereed, Not invited
  • Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands
    Tadashi Yasui; Hiroshi Gomi; Taishi Kitahara; Azuma Tsukise
    European Journal of Histochemistry, 2017, Refereed, Not invited
  • Granuphilin exclusively mediates functional granule docking to the plasma membrane
    Kouichi Mizuno; Takuji Fujita; Hiroshi Gomi; Tetsuro Izumi
    Scientific Reports, Apr. 2016, Refereed, Not invited
  • A new transgenic mouse model revealed a role of astrocytic calcium in vivo
    Mika Tanaka; Pei-Yu Shih; Hiroshi Gomi; Takamasa Yoshida; Junichi Nakai; Reiko Ando; Teiichi Furuichi; Katsuhiko Mikoshiba; Alexey Semyanov; Shigeyoshi Itohara
    JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015
  • The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane
    Hao Wang; Ray Ishizaki; Jun Xu; Kazuo Kasai; Eri Kobayashi; Hiroshi Gomi; Tetsuro Izumi
    Molecular Biology of the Cell, Feb. 2013, Refereed, Not invited
  • Cytochemistry of Sialoglycoconjugates, Lysozyme, and beta-Defensin in Eccrine Glands of Porcine Snout Skin as Studied by Electron Microscopy
    Kousuke Fukui; Tadashi Yasui; Hiroshi Gomi; Hiroshi Sugiya; Osamu Fujimori; Wilfried Meyer; Azuma Tsukise
    MICROSCOPY RESEARCH AND TECHNIQUE, Jan. 2013, Refereed, Not invited
  • Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses
    Mika Tanaka; Pei-Yu Shih; Hiroshi Gomi; Takamasa Yoshida; Junichi Nakai; Reiko Ando; Teiichi Furuichi; Katsuhiko Mikoshiba; Alexey Semyanov; Shigeyoshi Itohara
    Molecular Brain, Jan. 2013, Refereed, Not invited
  • Cytochemistry of sialoglycoconjugates and lysozyme in canine anal glands as studied by electron microscopic methods
    Takayuki Nara; Tadashi Yasui; Hiroshi Gomi; Hiroshi Sugiya; Osamu Fujimori; Wilfried Meyer; Azuma Tsukise
    Acta Histochemica, 2013, Refereed, Not invited
  • Histochemical distribution of sialic acids and antimicrobial substances in porcine carpal glands
    Kousuke Fukui; Tadashi Yasui; Hiroshi Gomi; Hiroshi Sugiya; Osamu Fujimori; Wilfried Meyer; Azuma Tsukise
    Archives of Dermatological Research, Oct. 2012, Refereed, Not invited
  • Histochemical localization of sialic acids and antimicrobial substances in eccrine glands of porcine snout skin
    Kosuke Fukui; Tadashi Yasui; Hiroshi Gomi; Hiroshi Sugiya; Osamu Fujimori; Wilfried Meyer; Azuma Tsukise
    European Journal of Histochemistry, 2012, Refereed, Not invited
  • Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain
    Miao Yu; Kazuo Kasai; Kazuaki Nagashima; Seiji Torii; Hiromi Yokota-Hashimoto; Koichi Okamoto; Toshiyuki Takeuchi; Hiroshi Gomi; Tetsuro Izumi
    Molecular Biology of the Cell, Feb. 2007, Refereed, Not invited
  • Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice
    Toyonori Kato; Hitoshi Shimano; Takashi Yamamoto; Tomotaka Yokoo; Yuko Endo; Mayumi Ishikawa; Takashi Matsuzaka; Yoshimi Nakagawa; Shin Kumadaki; Naoya Yahagi; Akimitsu Takahashi; Hirohito Sone; Hiroaki Suzuki; Hideo Toyoshima; Alyssa H. Hasty; Satoru Takahashi; Hiroshi Gomi; Tetsuro Izumi; Nobuhiro Yamada
    Cell Metabolism, Aug. 2006, Refereed, Not invited
  • Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse
    Shin Mizutani; Hiroshi Gomi; Isao Hirayama; Tetsuro Izumi
    Mammalian Genome, May 2006, Refereed, Not invited
  • Rab27a自然欠損マウスにおけるインスリン分泌障害
    河西 和雄; 今泉 美佳; 高橋 倫子; 水谷 伸; 菊田 敏輝; 河西 春郎; 永松 信哉; 五味 浩司; 泉 哲郎
    糖尿病, Apr. 2005
  • Functional analysis of Rab27a effector granuphilin in insulin exocytosis
    Tetsuro Izumi; Hiroshi Gomi; Seiji Torii
    Methods in Enzymology, 2005, Not refereed, Invited
  • The roles of Rab27 and its effectors in the regulated secretory pathways
    Tetsuro Izumi; Hiroshi Gomi; Kazuo Kasai; Shin Mizutani; Seiji Torii
    Cell Structure and Function, Oct. 2003, Refereed, Not invited
  • Role of radial fibers in controlling the onset of myelination
    Jin Nakahara; Masaaki Takemura; Hiroshi Gomi; Ken-ichiro Tsunematsu; Shigeyoshi Itohara; Hiroaki Asou; Masaharu Ogawa; Sadakazu Aiso; Kyoko Tan-Takeuchi
    Journal of Neuroscience Research, May 2003, Refereed, Not invited
  • Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice
    Subramaniam Ganesh; AntonioV Delgado-Escueta; Toshio Sakamoto; MariaRosa Avila; Jesus Machado-Salas; Yoshinobu Hoshii; Takumi Akagi; Hiroshi Gomi; Toshimitu Suzuki; Kenji Amano; Kishan Lal Agarwala; Yuki Hasegawa; Dong-Sheng Bai; Tokuhiro Ishihara; Tsutomu Hashikawa; Shigeyoshi Itohara; Eain M Cornford; Hiroaki Niki; Kazuhiro Yamakawa
    Human Molecular Genetics, May 2002, Refereed, Not invited
  • Disturbance of hippocampal long-term potentiation after transient ischemia in GFAP deficient mice
    Hidenobu Tanaka; Akira Katoh; Kenji Oguro; Kuniko Shimazaki; Hiroshi Gomi; Shigeyoshi Itohara; Toshio Masuzawa; Nobufumi Kawai
    Journal of Neuroscience Research, Jan. 2002, Refereed, Not invited
  • The exact expression of glial fibrillary acidic protein (GFAP) in trigeminal ganglion and dental pulp
    Hisao Ajima; Yoshiro Kawano; Ritsuko Takagi; Megumi Aita; Hiroshi Gomi; Margaret R Byers; Takeyasu Maeda
    Archives of Histology and Cytology, Dec. 2001, Refereed, Not invited
  • Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice
    Takahiro Moriya; Yuko Yoshinobu; Yasuko Kouzu; Akira Katoh; Hiroshi Gomi; Masayuki Ikeda; Tohru Yoshioka; Shigeyoshi Itohara; Shigenobu Shibata
    Journal of Neuroscience Research, Apr. 2000, Refereed, Not invited
  • Layer-specific NO dependence of long-term potentiation and biased NO release in layer V in the rat auditory cortex
    Hidemitsu Wakatsuki; Hiroshi Gomi; Masaharu Kudoh; Shinji Kimura; Kota Takahashi; Masayuki Takeda; Katsuei Shibuki
    Journal of Physiology, Nov. 1998, Refereed, Not invited
  • Unaltered secretion of beta-amyloid precursor protein in gelatinase a (matrix metalloproteinase 2)-deficient mice
    T Itoh; T Ikeda; H Gomi; S Nakao; T Suzuki; S Itohara
    JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1997, Refereed, Not invited
  • 小脳長期抑圧と運動学習
    五味浩司; 糸原重美
    実験医学(羊土社), Jul. 1996, Not refereed, Invited
    Lead
  • MICE DEFICIENT IN GAMMA-DELTA T-CELLS ARE RESISTANT TO LETHAL INFECTION WITH SALMONELLA-CHOLERAESUIS
    M EMOTO; H NISHIMURA; T SAKAI; K HIROMATSU; H GOMI; S ITOHARA; Y YOSHIKAI
    INFECTION AND IMMUNITY, Sep. 1995, Refereed, Not invited
  • THE ROLE OF GAMMA-DELTA T-CELLS IN PRIMING MACROPHAGES TO PRODUCE TUMOR-NECROSIS-FACTOR-ALPHA
    H NISHIMURA; M EMOTO; K HIROMATSU; S YAMAMOTO; K MATSUURA; H GOMI; T IKEDA; S ITOHARA; Y YOSHIKAI
    EUROPEAN JOURNAL OF IMMUNOLOGY, May 1995, Refereed, Not invited
  • 遺伝的海綿状脳症ラット(Zitter)におけるプリオン蛋白(Prn)遺伝子の解析.
    五味浩司,糸原重美,国枝哲夫,山内一也
    厚生省特定疾患「遅発性ウイルス感染」調査研究班 平成4年度研究報告書, Mar. 1993, Not refereed, Not invited
    Lead
  • 遺伝的海綿状脳症ラット(Zitter)における活性酸素種代謝関連酵素の変化
    五味浩司,上野郁子,山内一也
    厚生省特定疾患「遅発性ウイルス感染」調査研究班 平成3年度研究報告書, Mar. 1992, Not refereed, Not invited
    Lead
  • Auditory brain-stem response in zitter rats with genetic spongiform encephalopathy
    F OCHIKUBO; H GOMI; K KITAMURA; Y YOSHIKAWA; K YAMANOUCHI
    ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, Feb. 1992, Refereed, Not invited
  • 十九世紀の馬治療記録 -旧家所蔵日記から-
    五味浩司,長尾壮七
    日本獣医史学雑誌, Mar. 1989, Refereed, Not invited
    Lead
  • 遺伝的海綿状脳症ラット(Zitter)の空胞形成機序
    五味浩司,吉川泰弘,山内一也
    厚生省特定疾患「遅発性ウイルス感染」調査研究班 昭和62年度研究報告書, Mar. 1988, Not refereed, Not invited
    Lead

MISC

  • ASTROCYTIC CA(2+) SIGNALS AFFECT ON TRIPARTITE SYNAPSE STRUCTURE AND HIPPOCAMPUS-RELATED LEARNING AND MEMORY
    M. Tanaka; P. -Y. Shih; H. Gomi; T. Yoshida; J. Nakai; R. Ando; T. Furuichi; K. Mikoshiba; A. Semyanov; S. Itohara
    GLIA, Jul. 2013, Not refereed, Not invited
  • Astrocytic IP3-mediated Ca2+ signaling is required for functional integrity of tripartite synapse
    Mika Tanaka; Hiroshi Gomi; Junichi Nakai; Alexander Lebedinskiy; Pei-Yu Shih; Reiko Ando; Katsuhiko Mikoshiba; Alexey Semyanov; Shigeyoshi Itohara
    NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited
  • Reduced astrocytic IP3-mediated Ca2+ signaling results in behavioral abnormality in mice
    Mika Tanaka; Junichi Nakai; Alexander Lebedinskiy; Hiroshi Gomi; Katsuhiko Mikoshiba; Alexey Semyanov; Shigeyoshi Itohara
    NEUROSCIENCE RESEARCH, 2009, Not refereed, Not invited
  • インスリン抵抗性,肥満を伴う2型糖尿病モデルマウスTSODにおける脂肪重量に関わる遺伝子領域の解析.
    水谷伸,五味浩司,泉哲郎
    Diabetes Frontier, Aug. 2006, Not refereed, Not invited
  • Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
    Kasai Kazuo; Mica Ohara-Imaizumi; Noriko Takahashi; Shin Mizutani; Shengli Zhao; Toshiteru Kikuta; Haruo Kasai; Shinya Nagamatsu; Hiroshi Gomi; Tetsuro Izumi
    CELL STRUCTURE AND FUNCTION, Jun. 2005, Not refereed, Not invited
  • Roles of Rab27a and granuphilin in the docking of insulin granules onto the plasma membrane
    Tetsuro Izumi; Kazuo Kasai; Hiroshi Gomi
    Jpn J Physiol, Apr. 2005
    Last
  • アストログリア特異的遺伝子欠損マウスを用いたニューロン-グリア間の機能的連関の解析と行動関連遺伝子の機能探索.
    五味浩司
    北関東医学雑誌, Feb. 2003, Not refereed, Not invited
    Lead
  • Cell death in transgenic mice model of Lafora's disease
    J Machado-Salas; MR Avila; K Yamakawa; T Sakamato; Y Hoshii; T Akagi; H Gomi; T Suzuki; K Amano; KL Agarwala; Y Hasegawa; DS Bai; T Ishihara; T Hashikawa; S Itohara; E Cornford; H Niki; AV Delgado-Escueta
    ANNALS OF NEUROLOGY, 2003, Not refereed, Not invited
  • Deficit in aversive learning in mice abolished KKIAMRE, a learning-associated serine/threonine kinase
    H Gomi; T Sassa; S Itohara
    Neuroscience Research, 2000
    Lead
  • Isolation and Characterization of the Murine KKIAMRE Gene
    SASA T; GOMI H; SUN William; THOMPSON Richard F; ITOHARA S
    日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998, Not refereed, Not invited
  • Dynamic characteristics and adaptability of optokinetic and vestibular induced eye movements in mice lacking GFAP
    Akira Katoh; Hiromasa Kitazawa; Hiroshi Gomi; Shigeyoshi Itohara; Soichi Nagao
    Neuroscience Research, Jan. 1998
  • Fear conditioning behavior in GFAP mutant mice
    Yasuko Kouzu; Akira Katoh; Hiroshi Gomi; Shigeyoshi Itohara; Masashi Akiyama; Shigenobu Shibata
    Japanese Journal of Pharmacology, Jan. 1998
  • Eyeblink conditioning induces RNA encoding a CDC2-related kinase, KKIAMRE in the deep cerebellar nuclei
    Hiroshi Gomi; William Sun; Caleb E. Finch; Shigeyoshi Itohara; Kenji Yoshimi; Richard F. Thompson
    Neuroscience Research, Jan. 1998
    Lead
  • Molecular cloning of the murine KKIAMRE, a putative learning-associated kinase
    Takayuki Sassa; Hiroshi Gomi; William Sun; Richard F. Thompson; Shigeyoshi Itohara
    Neuroscience Research, Jan. 1998
  • アストログリア特異的に発現する Glial Fibrillary Acidic Protein (GFAP) の概日リズムにおける役割について
    吉信ゆう子; 川崎美帆; 神津靖子; 守屋孝洋; 池田真行; 吉岡亨; 加藤明; 五味浩司; 糸原重美; 柴田重信
    日本時間生物学会会誌: Journal of Chronobiology, 01 Oct. 1997, Not refereed, Not invited
  • Gelatinase A 遺伝子欠損マウスの解析
    伊藤剛; 池田敏男; 五味浩司; 加藤明; 糸原重美
    日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996, Not refereed, Not invited
  • Deficient cerebellar long-term depression, impaired eyeblinkconditioning and normal motor coordination in GFAP mutant mice
    Katsuei Shibuki; Hiroshi Gomi; Lu Chen
    Annual report, Brain Research Institute, Niigata University, 1995

Books and other publications

  • 獣医組織学(第九版)
    日本獣医解剖学会編; 山本欣郎; 編集委員長, Contributor, 第7章-2(pp. 129-147),第7章-4(pp. 155-159)
    学窓社, Mar. 2023
    9784873627878
  • 獣医組織学実習マニュアル(第2版)
    五味浩司、吉岡一機、坂上元栄 監修, Contributor, 序、第1章(pp.1-18)、第6章1〜7(pp.79-113)、第10章5(pp.188-189)
    学窓社, Sep. 2022
    9784873627854
  • 獣医組織学(第八版)
    日本獣医解剖学会編; 山本欣郎; 編集委員長, Contributor, 第7章-2(pp. 104-112),第7章-4(pp. 120-122)
    学窓社, Mar. 2020
    9784873627731
  • 獣医学教育モデル・コア・カリキュラム準拠 獣医解剖・組織・発生学(第2版)
    日本獣医解剖学会編; 九郎丸正道; 小川和重; 尼崎肇 監修, Contributor, 第8章(pp. 113-122),第13章(pp. 155-163)
    学窓社, Mar. 2019
  • Veterinary Embryology (Second edition)
    木曾康郎; 監訳, Single translation, 第13章(pp. 126-133)
    学窓社, Feb. 2019
  • 獣医組織学(第七版)
    日本獣医解剖学会編; 昆泰寛; 編集委員長, Contributor, 第7章-2(pp. 90-98),第7章-4(pp. 106-108)
    学窓社, Mar. 2017
  • 書いて覚える塗って身につく動物解剖学ノート
    尼崎肇,監修, Joint work, Unit37(pp. 92-93, pp. 149)
    講談社, Mar. 2016
  • カラーアトラス獣医解剖学 増補改訂第2版(上巻・下巻)
    カラーアトラス獣医解剖学編集委員会; 監訳, Joint editor, 序章(pp. 27-84)
    チクサン出版, Mar. 2016
  • 猫の解剖カラーリングアトラス
    九郎丸正道; 監修, Single translation, 図版1および2
    学窓社, Sep. 2014
  • Essentials of Domestic Animal Embryology
    山本雅子; 谷口和美; 監訳, Single translation, 第8章(pp. 105-114),第13章(pp. 227-236)
    緑書房, Apr. 2014
  • 獣医組織学(第六版)
    日本獣医解剖学会編; 昆泰寛; 編集委員長, Contributor, 第7章-2中枢神経系(pp. 92-100),第7章-4髄膜と脳脊髄液(pp. 107-109)
    学窓社, Mar. 2014
    9784873627441
  • 牛の解剖アトラス(増補改訂第2版)
    日本獣医解剖学会編; 橋本善春, Joint editor, pp. 1-182
    緑書房, Sep. 2013
  • 獣医学教育モデル・コア・カリキュラム準拠 獣医解剖・組織・発生学
    日本獣医解剖学会編; 九郎丸正道; 小川和重; 尼崎肇,監修, Contributor, 第8章(pp. 113-122),第13章(pp. 155-163)
    学窓社, May 2012
  • 高まる研究力:すいβ細胞におけるインスリン分泌顆粒に関する研究 〜異なるアプローチからインスリン分泌機構に迫る〜 変革する大学シリーズ 群馬大学(2007-2008年版)
    穂坂正博; 五味浩司, Joint work, pp. 86-88
    日経BPムック, Jan. 2007
  • Deficient cerebellar long-term depression and impaired motor learning in GFAP mutant mice. (Gene Targeting and New Development in Neurobiology, Shigetada Nakanishi, Alcino J. Silva, Shinichi Aizawa, Motoya Katsuki eds.)
    Shigeyoshi Itohara; Hiroshi Gomi, Joint work, pp. 37-46
    Japan Scientific Societies Press, Karger, Apr. 1996
    3805564015

Lectures, oral presentations, etc.

  • 下垂体コルチコトロフおよびコルチコトロフ由来AtT-20細胞におけるグラニンタンパク質発現の分子・形態学的解析
    菊池正太; 小田嶋航希; 安井禎; 穂坂正博; 五味浩司
    第167回日本獣医学会学術集会, Sep. 2024
  • 分泌顆粒へのホルモン輸送機構が冗長性を持つ意義:生活習慣病の危険因子としてのグラニンタンパク質不全
    穂坂正博; 五味浩司; 渡部剛
    先端モデル動物支援プラットフォーム成果発表会, Feb. 2024, Not invited
  • インスリン分泌でセクレトグラニンが果たす役割
    平島優花; 河田秋音; 五味浩司; 渡部剛; 穂坂正博
    第96回日本生化学会大会, Oct. 2023
  • セクレトグラニが制御する下垂体前葉ホルモンの分泌/産生
    河田秋音; 平島優花; 五味浩司; 渡部剛; 穂坂正博
    第96回日本生化学会大会, Oct. 2023
  • ラット腺性下垂体ACTH産生細胞(コルチコトロフ)におけるグラニンタンパク質発現の形態学的解析
    菊池正太; 安井禎; 穂坂正博; 五味浩司
    第166回日本獣医学会学術集会, Sep. 2023
  • インスリン分泌でセクレトグラニンIIが果たす役割を個体レベルで明らかにする
    平島優花; 河田秋音; 五味浩司; 渡部剛; 穂坂正博
    第89回日本生化学会東北支部例会・シンポジウム, Jun. 2023
  • グラニンタンパク質が制御する下垂体前葉ホルモンの分泌・産生を明らかにする
    河田秋音; 平島優花; 五味浩司; 渡部剛; 穂坂正博
    第89回日本生化学会東北支部例会・シンポジウム, Jun. 2023
  • The role of secretogranin III in the endocrine cells of adrenal gland.
    岩﨑拓美; 五味浩司; 渡部剛; 穂坂正博
    第95回日本生化学会大会, Nov. 2022, Not invited
  • SecretograninⅢジーントラップマウスにおけるLacZ遺伝子発現パターンの解析
    五味浩司; 安井禎; 日當愛梨; 鳥居征司; 穂坂正博
    第163回日本獣医学会学術集会, Sep. 2020, 日本獣医学会, Not invited
  • イヌ涙腺上皮の形態ならびに組織化学的解析
    安井禎; 宮田健也; 中塚千枝; 髙橋直紀; 五味浩司
    第163回日本獣医学会学術集会, Sep. 2020, 日本獣医学会, Not invited
  • セクレトグラニンIIIを発現する細胞・組織を網羅的に明らかにする
    日當愛梨; 安井禎; 五味浩司; 穂坂正博
    第92回日本生化学会大会, Sep. 2019, 日本生化学会, Not invited
  • 分泌顆粒蛋白質フォグリンによるインスリン分泌とシグナルの連結機構
    久保田知里; 齊藤直也; 河野あゆみ; 竹内利行; 小林雅樹; 北村忠弘; 穂坂正博; 五味浩司; 鳥居征司
    第91回日本生化学会大会, Sep. 2018, Not invited
  • イヌ口腔腺におけるRabおよびSNAREタンパク質の発現解析
    五味浩司; 大澤裕美; 宇野理恵; 安井禎; 鳥居征司; 穂坂正博; 月瀬東
    第161回日本獣医学会学術集会, Sep. 2018, Not invited
  • イヌ涙腺における糖質ならびに免疫組織化学的解析
    安井禎; 五味浩司
    第161回日本獣医学会学術集会, Sep. 2018, Not invited
  • ニワトリ内分泌器官におけるセクレトグラニンIIIの発現解析
    五味浩司; 安井禎; 鳥居征司; 穂坂正博
    第159回日本獣医学会学術集会, Sep. 2016, Not invited
  • シバヤギ耳道腺における抗菌物質と分泌制御タンパク質の免疫組織化学的解析
    安井禎; 五味浩司
    第159回日本獣医学会学術集会, Sep. 2016, Not invited
  • Immunohistochemical analysis of IA2 family of protein-tyrosine phosphatases in rat gastrointestinal endocrine cells
    Hiroshi Gomi; Chisato Murata; Seiji Torii
    The 86th Annual Meeting of the Japanese Biochemical Society, Sep. 2013, Not invited
  • Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain
    K. Kasai; M. Yu and K. Nagashima et al.
    8th Servier-IGIS Symposium, France, Mar. 2007, Not invited
  • Rab27b expression and role in pituitary secretory cells
    H. Gomi; K. Mori and S. Itohara et al.
    2nd COE International Symposium "Molecular Physiology and Pathology of Membrane Traffic." Maebashi, Japan, Nov. 2006, Not invited
  • Analysis of lacZ reporter gene expression in Rab27b-deficient mice
    H. Gomi; S. Zhao and K. Mori et al.
    1st COE International Symposium "Molecular Mechanisms of Vesicle Trafficking and Membrane Fusion." Maebashi, Japan, Nov. 2003, Not invited
  • Cell death in transgenic mice model of Laforaユs disease
    J. Machado-Salas; M.R. Avila and K. Yamakawa et al.
    128th Annuanl Meeting of American Neurological Association. San Francisco, USA, Oct. 2003, Not invited
  • Cell death and neuropilee changes in the cerebellum of a KO mouse model of Lafora disease, antedatelafora bodies accumulation
    M. Avila-Costa; A.V. Delgado-Escueta and J. Machado-Salas et al.
    32nd Annuanl Meeting of Society for Neuroscience. Orlando, USA, Nov. 2002, Not invited
  • Eyeblink classical conditioning in mice defcient in KKIAMRE
    R.M. Hinchlife; H. Gomi and R.F. Thompson
    31st Annuanl Meeting of Society for Neuroscience. San Diego, USA, Nov. 2001, Not invited
  • Deficits in aversive learning in mice abolished KKIAMRE, a learning-associated serine/threonine kinase
    H. Gomi; T. Sassa and S. Itohara
    30th Annuanl Meeting of Society for Neuroscience. New Orleans, USA, Nov. 2000, Not invited
  • Transgenic mouse model that accumulates a senile human brain-specific Pathological form of amyloidβ peptide, Ab3(PE)-42
    H-J. Lee; H. Gomi and N. Iwata et al.
    30th Annuanl Meeting of Society for Neuroscience. New Orleans, USA, Nov. 2000, Not invited
  • Disturbed hippocampal functions of GFAP knockout mice after transient ischemia
    H. Tanaka; A. Katoh and K. Shimazaki et al.
    29th Annuanl Meeting of Society for Neuroscience. Miami Beach, USA, Oct. 1999, Not invited
  • Transcriptional characteristics of the KKIAMRE, a learning- associate kinase, revealed by mutant mice carrying the reporter gene LacZ
    H. Gomi; T. Sassa and W. Sun et al.
    29th Annuanl Meeting of Society for Neuroscience. Miami Beach, USA, Oct. 1999, Not invited
  • Molecular cloning of the murine KKIAMRE, a learning-associated protein kinase
    H. Gomi; T. Sassa and W. Sun et al.
    28th Annuanl Meeting of Society for Neuroscience. Los Angeles, USA, Nov. 1998, Not invited
  • Dynamic characteristics and adaptability of reflex eye movements in mice lacking GFAP
    A. Katoh; H. Kitazawa and H. Gomi et al.
    28th Annuanl Meeting of Society for Neuroscience. Los Angeles, USA, Nov. 1998, Not invited

Affiliated academic society

  • Oct. 2015 - Present
    The Histochemical Society
  • Dec. 2010 - Present
    日本解剖学会
  • Sep. 1998 - Present
    Society for Neuroscience
  • Aug. 1998 - Present
    日本神経科学会
  • Apr. 1989 - Present
    日本獣医解剖学会
  • Apr. 1989 - Present
    日本獣医学会
  • Dec. 1995 - Mar. 1999
    日本分子生物学会

Research Request Themes

Research Themes

  • Developing a method to sustainably protect neurons with radical-trapping compounds
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2024 - Mar. 2027
    鳥居 征司; 五味 浩司
  • セクレトグラニンⅢの機能的多様性と疾患関連性の解析
    2020 - 2023
  • 分泌顆粒蛋白質による膵島細胞分別の試み
    群馬大学生体調節研究所, 「内分泌・代謝学共同研究拠点」共同研究, 2019 - 2020
  • ペプチドホルモンの分泌顆粒形成と分解機構(分泌顆粒の生涯)の解明
    2016 - 2018
  • ペプチドホルモン生成と分泌顆粒形成機構の連関を探る
    群馬大学生体調節研究所, 「内分泌・代謝学共同研究拠点」共同研究, 2015 - 2017
  • Stabilizing endocrine cell function by phogrin.
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2012 - Mar. 2016
    TORII SEIJI; GOMI Hiroshi; NAMEKI Nobukazu; MOGAMI Hideo
  • 消化管内分泌細胞におけるIA-2ファミリー蛋白質の役割
    2013 - 2015
    五味浩司
  • 分泌顆粒膜蛋白質フォグリンの消化管における役割の解明
    群馬大学生体調節研究所, 「内分泌・代謝学共同研究拠点」共同研究, 2012 - 2015
  • アストロサイト・ニューロン間クロストークに関する研究
    2012 - 2014
  • グリオトランスミッターの機能解析
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2010 - 2012
    GOMI Hiroshi; ITOHARA Shigeyoshi
  • 神経微細構造変化の定量的解析技術の開発
    2009 - 2009
  • Alexander病の疾患モデルマウスの作製と解析
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2005 - 2008
    GOMI Hiroshi
  • 低分子量Gタンパク質による分泌顆粒輸送
    群馬大学21世紀COEプログラム「生体情報の受容伝達と機能発現」, 2002 - 2006
    岡島史和
  • 蛍光蛋白質と遺伝子変異マウスを用いた、インスリン細胞内輸送動態の視覚的解析
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2004 - 2005
    IZUMI Testuro; GOMI Hiroshi
  • 多因子遺伝性糖尿病・肥満モデルマウスの成因遺伝子の解明
    日本学術振興会, 科学研究費助成事業, 2002 - 2003
    泉 哲郎; 水谷 伸; 五味 浩司
  • マウスkkiamreキナーゼの発現制御機構と高次神経機能における役割
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2001 - 2003
    GOMI Hiroshi
  • 脳の聴覚情報処理機構におけるアストログリアの役割
    日本学術振興会, 科学研究費助成事業, 1998 - 1999
    五味 浩司
  • GFAP変異マウスを用いたシナプス可塑性に関する研究
    1996 - 1997
    五味浩司

Social Contribution Activities

  • 食鳥処理衛生管理者登録講習会(家きん解剖・生理学)
    lecturer
    公益社団法人日本食品衛生協会, 09 Feb. 2017 - Present
  • 家畜防疫員(豚熱防疫措置)
    organizing_member
    神奈川県, 18 Jul. 2021