Kaneko Keisuke

School of Dentistry Department of DentistryAssistant Professor

Degree

  • D.D.S., Nihon University School of Dentistry, 2014
  • Ph.D., Nihon University Graduate School of Dentistry, 2019

Research Keyword

  • Anesthetic
  • Hippocampus
  • Cerebral cortex
  • Ion channel
  • Dravet syndrome
  • Neurodevelopmental disorder
  • Neural circuit
  • Synaptic transmission
  • Action potential
  • Interneuron

Field Of Study

  • Life sciences, Anesthesiology
  • Life sciences, Physiology
  • Life sciences, Pharmacology
  • Life sciences, Neuroscience - general
  • Life sciences, Morphology, anatomy
  • Life sciences, Cell biology

Career

  • Apr. 2021 - Present
    Nihon University School of Dentistry, Department of Anesthesiology, Assistant Professor
  • Apr. 2019 - Mar. 2021
    Children’s Hospital of Philadelphia, Division of Neurology, Department of Pediatrics, Post-Doctoral Fellow
  • Apr. 2017 - Mar. 2019
    Nihon University Graduate School of Dentistry, Department of Anesthesiology, Research assistant

Educational Background

  • 2015 - 2019
    Nihon University, Graduate School of Dentistry
  • 2007 - 2014
    Nihon University, School of Dentistry, 歯学科

Award

  • Society for Neuroscience, SfN (Society for Neuroscience) – JNS (Japan Neuroscience Society) Exchange Travel Award
    ★, International society
    Keisuke Kaneko and Ethan M. Goldberg
  • American Epilepsy Society, Grass Foundation – AES (American Epilepsy Society) Young Investigator Award
    ★, International society
    Keisuke Kaneko and Ethan M. Goldberg
  • 佐藤奨学金
  • ロバート・ケネディ奨学金
  • モリタ・ハノー補綴学賞

Paper

  • ★Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy
    Huijie Feng; Jerome Clatot; Keisuke Kaneko; Marco Flores-Mendez; Eric R. Wengert; Carly Koutcher; Emily Hoddeson; Emily Lopez; Demetrius Lee; Leroy Arias; Qiansheng Liang; Xiaohong Zhang; Ala Somarowthu; Manuel Covarrubias; Martin J. Gunthorpe; Charles H. Large; Naiara Akizu; Ethan M. Goldberg
    Cell Reports Medicine, Jan. 2024, Refereed
  • ★Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome
    Keisuke Kaneko; Christopher B. Currin; Kevin M. Goff; Eric R. Wengert; Ala Somarowthu; Tim P. Vogels; Ethan M. Goldberg
    Cell Reports, Mar. 2022, Refereed, Not invited
    Lead
  • ★Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome
    Joanna Mattis; Ala Somarowthu; Kevin M Goff; Evan Jiang; Jina Yom; Nathaniel Sotuyo; Laura M Mcgarry; Huijie Feng; Keisuke Kaneko; Ethan M Goldberg
    eLife, Feb. 2022, Refereed
  • ★Propofol-induced potentiation of GABAA receptor-mediated tonic Cl-currents in the rat insular cortex
    金子啓介
    Mar. 2019, Refereed, Not invited
    Lead
  • ★Propofol-induced spike firing suppression is more pronounced in pyramidal neurons than in fast-spiking neurons in the rat insular cortex.
    Keisuke Kaneko
    Neuroscience, Oct. 2016, Refereed, Not invited
    Lead
  • Desflurane-Induced Delayed Onset of Malignant Hyperthermia: A Case Report.
    Seki H; Takei N; Kajiwara M; Tsumura M; Naito N; Tsujiuchi M; Higa M; Koyanagi Y; Oka S; Kaneko K
    Anesthesia Progress, Jun. 2026, Refereed
    Last
  • A new phenotype identification method with the fluorescent expression in cross-sectioned tails in Thy1-GCaMP6s transgenic mice
    Shutaro Kobayashi; Kazunori O’Hashi; Keisuke Kaneko; Satomi Kobayashi; Shouhei Ogisawa; Morio Tonogi; Satoshi Fujita; Masayuki Kobayashi
    Journal of Oral Science, Feb. 2022, Refereed
  • Presynaptic NK1 Receptor Activation by Substance P Suppresses EPSCs via Nitric Oxide Synthesis in the Rat Insular Cortex.
    Keisuke Kaneko
    Neuroscience, Dec. 2020, Refereed, Not invited
  • Orexin facilitates GABAergic IPSCs via postsynaptic OX1 receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex.
    Keisuke Kaneko
    Neuropharmacology, Feb. 2019, Refereed, Not invited
  • Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study.
    Keisuke Kaneko
    Neuroscience letters, Dec. 2018, Refereed, Not invited

MISC

  • 術後瘢痕による口唇開閉不能患者の全身麻酔経験
    佐藤裕美, 内田琢也, 里見ひとみ, 金子啓介, 新渡未樹, 岡村祐香, 田口香織, 岡俊一, 大井良之
    日本歯科麻酔学会雑誌, 2018, Refereed, Not invited
  • Sensor-augmented pump により術後の低血糖に迅速に対応しえた 1 型糖尿病患者の全身麻酔経験
    里見ひとみ, 関野麗子, 新渡未樹, 田口香織, 岡村祐香, 金子啓介, 見﨑徹, 大井良之
    日本歯科麻酔学会雑誌, 2018, Refereed, Not invited

Lectures, oral presentations, etc.

  • ★Neocortical parvalbumin-positive fast-spiking GABAergic interneurons exhibit persistent deficits in axonal function in an experimental mouse model of Dravet syndrome
    Keisuke Kaneko and Ethan M. Goldberg
    Better Patient Outcomes through Diversity Poster session in American Epilepsy Society 2020 Annual Meeting, Dec. 2020, American Epilepsy Society, Invited
  • ★Neocortical parvalbumin-positive fast-spiking GABAergic interneurons exhibit persistent deficits in axonal function in an experimental mouse model of Dravet syndrome
    Keisuke Kaneko and Ethan M. Goldberg
    American Epilepsy Society 2020 Annual Meeting, Dec. 2020, American Epilepsy Society, Not invited
  • Neocortical parvalbumin-positive interneurons exhibit persistent deficits in axonal function in an experimental mouse model of Dravet syndrome (Scn1a+/- mice)
    Keisuke Kaneko and Ethan M. Goldberg
    36th Annual MINS UnRetreat Symposium, Apr. 2020, Mahoney Institute for Neurosciences, Not invited
  • Neocortical parvalbumin-positive interneurons exhibit persistent deficits in axonal function in an experimental mouse model of Dravet syndrome
    Keisuke Kaneko and Ethan M. Goldberg
    Japan Neuroscience Society 2020, 2020, Not invited
  • Cholinergic inputs to cortical cholinergic interneurons facilitate disinhibition of excitatory neurons in the rat cerebral cortex
    金子啓介,松村幸恵,藤田智史,小林真之
    三叉神経領域の感覚-運動統合機構研究会, Dec. 2018, Not invited
  • Cholinergic inputs to cortical cholinergic neurons facilitate disinhibition of excitatory neurons in the rat cerebral cortex
    Keisuke Kaneko; Sachie Matsumura; Yoshiyuki Oi; Masayuki Kobayashi
    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology), 2018, Not invited
  • Cholinergic inputs to cortical cholinergic neurons facilitate disinhibition of excitatory neurons in the rat cerebral cortex
    Kaneko K; Matsumura S; Oi Y; and Kobayashi M
    Society for Neuroscience 2018, 2018, Not invited
  • Effects of propofol on the electrophysiological membrane properties of pyramidal ,neurons and GABAergic interneurons in the rat agranular insular cortex
    3.Keisuke Kaneko; Yuko Koyanagi; Masayuki Kobayashi; Yoshiyuki Oi
    日本麻酔科学会第64回学術集会, Jun. 2017, Not invited
  • ラット大脳皮質に存在するコリン作動性ニューロンの役割
    金子啓介; 小林真之; 大井良之
    第69回日本大学歯学会総会・学術大会, May 2017, 日本大学歯学部, Not invited
  • Propofol-mediated spike firing suppression is more sensitive in pyramidal neurons,than in fast-spiking interneurons in the rat insular cortex
    2.Keisuke Kaneko; Yuko Koyanagi; Yoshiyuki Oi; Masayuki Kobayashi
    Society for Neuroscience, Nov. 2016, Not invited
  • Neuronal subtype-dependent modulation of electrophysiological properties by propofol,in rat cerebral cortex
    1.Keisuke Kaneko; Yuko Koyanagi; Yoshiyuki Oi; Masayuki Kobayashi
    第89回日本薬理学会年会, Mar. 2016, Not invited

Affiliated academic society

  • 2025 - Present
    Japanese Heart Rhythm Society
  • 2024 - Present
    Japanese Society of Anesthesiologists
  • 2016 - Present
    Japanese Dental Society of Anesthesiology
  • 2020 - 2023
    Japan Neuroscience Society
  • 2018 - 2023
    Society for Neuroscience

Research Request Themes

  • Neurodevelopmental disorder

Research Themes

  • 意識と覚醒に着目したプロポフォールの新しい催眠メカニズムの調査
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2022 - Mar. 2025
    Keisuke Kaneko
  • Elucidation of Autonomic Cardiovascular Regulatory Mechanisms Using Noninvasive Hemodynamic Monitoring in a Physiological Hemorrhage Model
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2026 - 31 Mar. 2028
    金子 啓介
  • Opioid subtype-dependent regulation of inhibitory synaptic transmission and excitatory propagation in the rat insular cortex
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2016 - Mar. 2019
    OI Yoshiyuki; YOKOTA Eiko; KANEKO Keisuke