コロナウイルス

Bovine leukosis

Feline infectious peritonitis

Infectious diseases of domestic and companion animals

Equine infectious anemia

Life sciences, Veterinary medicine, Applied Veterinary Science

Apr. 2018 - Present
Nihon University College of Bioresource Sciences, School of Veterinary Medicine, Associate Professor

Apr. 2015 - Mar. 2018
Nihon University College of Bioresource Sciences, School of Veterinary Medicine, Assistant Professor

Apr. 2014 - Mar. 2015
Nihon University College of Bioresource Sciences, School of Veterinary Medicine, Assistant Professor

Apr. 2011 - Mar. 2014
Nihon University College of Bioresource Sciences, School of Veterinary Medicine, Research Assistant

01 Apr. 2009 - 25 Mar. 2011
Kanazawa University Cancer Research Institute, Division of Genetics, JSPS Research Fellow

Apr. 2009 - Mar. 2011
Kanazawa University Cancer Research Institute, Division of Genetics, JSPS Research Fellow

01 Apr. 2006 - 31 Mar. 2009
Kanazawa University Cancer Research Institute, Division of Genetics, Postdoctoral fellow

Apr. 2006 - Mar. 2009
Kanazawa University Cancer Research Institute, Division of Genetics, Postdoctoral fellow

01 Apr. 2001 - 31 Mar. 2005
Nihon University, Graduate School of Veterinary Medicine, Veterinary Sciences

Apr. 2001 - Mar. 2005
Nihon University, Graduate School of Veterinary Medicine, Veterinary Sciences

01 Apr. 1995 - 31 Mar. 2001
Nihon University, Faculty of Agriculture and Veterinary Medicine, School of Veterinary Medicine

Apr. 1995 - Mar. 2001
Nihon University, Faculty of Agriculture and Veterinary Medicine, School of Veterinary Medicine

Genomic characterization and distribution of bovine foamy virus in Japan.
Okamoto M; Oguma K; Yamashita-Kawanishi N; Ichijo T; Hatama S; Endo M; Ishikawa M; Haga T.
Journal of Veterinary Medical Science, Sep. 2020, Refereed, Not invited

Survey of bovine foamy virus infection among cattle in Japan and comparison with bovine leukemia virus infection.
Ryoji IWASAKI; Yu NAKAGIRI; Yuji YAGUCHI; Keisuke OGUMA; Mamiko ONO; Tetsuya HORIKITA; Hiroshi SENTSUI
Journal of Veterinary Medical Science, Mar. 2020, Refereed, Not invited

Evaluation of serological assays available in a biosafety level 2 laboratory and their application for survey of Middle East Respiratory Syndrome Coronavirus among livestock in Ethiopia.
Teramichi T; Fukushi S; Hachiya Y; Melaku SK; Oguma K; Sentsui H
Journal of Veterinary Medical Science, Dec. 2019, Refereed, Not invited

Transcriptional activation of long terminal repeat of bovine leukemia virus by bovine heat shock factor 1.
Hachiya Y; Oguma K; Koshida T; Koba R; Sentsui H.
Virus Research, Jun. 2019, Refereed, Not invited

Isolation of bovine foamy virus in Japan.
Hachiya Y; Kimura K; Oguma K; Ono M; Horikita T; Sentsui H.
Journal of Veterinary Medical Science, Sep. 2018, Refereed, Not invited

Mutation of the S and 3c genes in genomes of feline coronaviruses.
Oguma K; Ohno M; Yoshida M; Sentsui H.
Journal of Veterinary Medical Science, Jul. 2018, Refereed, Not invited
Lead

Detection of Equine Herpesvirus (EHV)-1,-2,-4 and-5 in Ethiopian Equids with and without Respiratory Problems and Genetic Characterization of EHV-2 and EHV-5 Strains
H. Negussie; D. Gizaw; L. Tesfaw; Y. Li; K. Oguma; H. Sentsui; T. S. Tessema; H. J. Nauwynck
TRANSBOUNDARY AND EMERGING DISEASES, Dec. 2017, Refereed, Not invited

Enzootic bovine leukosis in a two-month-old calf
Keisuke Oguma; Miho Suzuki; Hiroshi Sentsui
VIRUS RESEARCH, Apr. 2017, Refereed, Not invited

Preparation of a cell line persistently infected with maedi/visna virus and production of viral antigens
Kazuya Suzuki; Keisuke Oguma; Hiroshi Sentsui
JOURNAL OF VETERINARY MEDICAL SCIENCE, Jan. 2017, Refereed, Not invited

Serological survey of viral diseases relating to reproductive failure among Artiodactyla in Ethiopian Camelus dromedarius
Simenew Keskes Melaku; Fekadu Regassa; Tesfaye Sisay Tessema; Fufa Dawo; Keisuke Oguma; Kumiko Nagayama; Hiroshi Sentsui
MICROBIOLOGY AND IMMUNOLOGY, Jul. 2016, Refereed, Not invited

Overexpression of feline tripartite motif-containing 25 interferes with the late stage of feline leukemia virus replication
Ryota Koba; Keisuke Oguma; Hiroshi Sentsui
VIRUS RESEARCH, Jun. 2015, Refereed, Not invited

Isolation of Maedi/Visna Virus from a Sheep in Japan
Keisuke Oguma; Chiaki Tanaka; Ryo Harasawa; Atsushi Kimura; Jun Sasaki; Masanobu Goryo; Hiroshi Sentsui
JOURNAL OF VETERINARY MEDICAL SCIENCE, Feb. 2014, Refereed, Not invited

Amplification of complete gag gene sequences from geographically distinct equine infectious anemia virus isolates
Boldbaatar B; Bazartseren T; Koba R; Murakami H; Oguma K; Murakami K; Sentsui H.
Journal of Virological Methods, Jan. 2013, Refereed, Not invited

Efficient propagation of equine viruses in a newly established equine cell line, FHK-Tcl3.1 cells
Keisuke Oguma; Maiko Ishida; Ken Maeda; Hiroshi Sentsui
Journal of Veterinary Medical Science, 2013, Refereed, Not invited

Characterization of feline TRIM genes: Molecular cloning, expression in tissues, and response to type I interferon
Ryota Koba; Chika Kokaji; Gentoku Fujisaki; Keisuke Oguma; Hiroshi Sentsui
Veterinary Immunology and Immunopathology, 2013, Refereed, Not invited

Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells
D. Kong; Y-S Piao; S. Yamashita; H. Oshima; K. Oguma; S. Fushida; T. Fujimura; T. Minamoto; H. Seno; Y. Yamada; K. Satou; T. Ushijima; T-O Ishikawa; M. Oshima
ONCOGENE, Aug. 2012, Refereed, Not invited

Activation of epidermal growth factor receptor signaling by the prostaglandin E-2 receptor EP4 pathway during gastric tumorigenesis
Hiroko Oshima; Boryana K. Popivanova; Keisuke Oguma; Dan Kong; Tomo-o Ishikawa; Masanobu Oshima
CANCER SCIENCE, Apr. 2011, Refereed, Not invited

Prostaglandin E-2 2 Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors
Hiroko Oshima; Kyoji Hioki; Boryana K. Popivanova; Keisuke Oguma; Nico Van Rooijen; Tomo-O Ishikawa; Masanobu Oshima
GASTROENTEROLOGY, Feb. 2011, Refereed, Not invited

Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development
Keisuke Oguma; Hiroko Oshima; Masanobu Oshima
FUTURE ONCOLOGY, Apr. 2010, Refereed, Not invited

Prostaglandin E-2, Wnt, and BMP in gastric tumor mouse models
Hiroko Oshima; Keisuke Oguma; Yu-Chen Du; Masanobu Oshima
CANCER SCIENCE, Oct. 2009, Refereed, Not invited

Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis
Yu-Chen Du; Hiroko Oshima; Keisuke Oguma; Takanori Kitamura; Hiraku Itadani; Takashi Fujimura; Ying-Shi Piao; Tanihiro Yoshimoto; Toshinari Minamoto; Hidehito Kotani; Makoto M. Taketo; Masanobu Oshima
GASTROENTEROLOGY, Oct. 2009, Refereed, Not invited

胃がん発生におけるTNF-αとWntシグナル
小熊圭祐、大島正伸
分子細胞治療, Aug. 2009, Not refereed, Invited
Lead

Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
Keisuke Oguma; Hiroko Oshima; Masahiro Aoki; Ryusei Uchio; Kazuhito Naka; Satoshi Nakamura; Atsushi Hirao; Hideyuki Saya; Makoto Mark Taketo; Masanobu Oshima
EMBO JOURNAL, Jun. 2008, Refereed, Not invited

The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line
Kota Nagamatsu; Fumito Tsuchiya; Keisuke Oguma; Haruhiko Maruyama; Rui Kano; Atsuhiko Hasegawa
RESEARCH IN VETERINARY SCIENCE, Feb. 2008, Refereed, Not invited

Apoptosis of canine mammary tumor cells induced by small interfering RNA (siRNA) against Bcl-xL gene
Fumito Tsuchiya; Rui Kano; Junichi Sano; Keisuke Oguma; Atsuhiko Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, Nov. 2006, Refereed, Not invited

In vitro effect of recombinant human tumor necrosis factor-alpha on canine neutrophil apoptosis
K Oguma; J Sano; R Kano; T Watari; A Hasegawa
RESEARCH IN VETERINARY SCIENCE, Apr. 2006, Refereed, Not invited

Molecular cloning and tissue expression of canine Toll-like receptor 2 (TLR2)
M Ishii; M Hashimoto; K Oguma; R Kano; T Moritomo; A Hasegawa
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Mar. 2006, Refereed, Not invited

In vitro effect of recombinant human granulocyte colony-stimulating factor on canine neutrophil apoptosis
K Oguma; J Sano; R Kano; T Watari; T Moritomo; A Hasegawa
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Dec. 2005, Refereed, Not invited

Effect of antineoplastic drugs on the expression of Bcl-2 and Bcl-xL genes in the feline T-cell leukemia cell line
J Sano; S Nagafuchi; J Yamazaki; K Oguma; R Kano; A Hasegawa
RESEARCH IN VETERINARY SCIENCE, Dec. 2005, Refereed, Not invited

High expression of Bcl-xL in delayed apoptosis of canine neutrophils induced by lipopolysaccharide
J Sano; K Oguma; R Kano; M Yazawa; H Tsujimoto; A Hasegawa
RESEARCH IN VETERINARY SCIENCE, Apr. 2005, Refereed, Not invited

Molecular cloning of canine thrombomodulin cDNA and expression in normal tissues
H Maruyama; K Oguma; S Maeda; R Kano; H Tsujimoto; T Watari; M Tokuriki; A Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, Nov. 2004, Refereed, Not invited

Molecular cloning of canine mcl-1 gene and its expression in tumor cell lines
J Sano; K Oguma; R Kano; A Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, Jun. 2004, Refereed, Not invited

Characterization of canine caspase-3
J Sano; K Oguma; R Kano; A Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, May 2004, Refereed, Not invited

Decreased apoptotic polymorphonuclear leukocyte rate in dogs with pyometra
J Sano; K Oguma; R Kano; S Tsumagari; A Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, Jan. 2004, Refereed, Not invited

Accelerated neutrophil apoptosis in 2 canine cases of hepatic disorder
K Oguma; J Sano; R Kano; T Watari; A Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, Mar. 2003, Refereed, Not invited

Canine Bcl-xL gene and its expression in tumor cell lines
J Sano; K Oguma; R Kano; A Hasegawa
JOURNAL OF VETERINARY MEDICAL SCIENCE, Jan. 2003, Refereed, Not invited

In vitro study of neutrophil apoptosis in dogs
K Oguma; R Kano; A Hasegawa
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Aug. 2000, Refereed, Not invited

1カ月齢の和牛子牛で若齢型牛伝染性リンパ腫を疑った1症例
有常眞菜美; 佐藤弘泰; 田中秀和; 小熊圭祐; 近藤広孝; 綿村崇宏
家畜診療, 2021

Characterization of Vertical Transmission of Bovine Leukemia Virus Observed in a Dairy Farm
岡本麻里; 杉浦勝明; 小熊圭祐; 猪熊壽; 遠藤麻衣子; THI Le Dung; 山下(川西)奈那子; 芳賀猛
獣医疫学雑誌, 2021

A case of suspected enzootic bovine leukosis in a 1-month-old Japanese Black calf
有常眞菜美; 佐藤弘泰; 田中秀和; 小熊圭祐; 近藤広孝; 綿村崇宏
家畜診療, 2021

非滲出型猫伝染性腹膜炎と診断した猫1例
高橋利尚; 小熊圭祐; 亘敏広; 亘敏広
動物臨床医学会年次大会プロシーディング, 2019

抗体陰性の牛ヘルペスウイルス4型持続感染牛の検出
村山芽依; 小熊圭祐; 大野真美子; 堀北哲也; 泉對博
日本獣医学会学術集会講演要旨集, 2019

関東地方の牧場におけるBovine Foamy Virusの疫学調査
中桐由布; 岩崎亮二; 矢口裕司; 小熊圭祐; 大野真美子; 堀北哲也; 泉對博
日本獣医学会学術集会講演要旨集, 2019

牛ヘルペスウイルス4型(BoHV-4)の抗体検査法の検討
阿野貴弘; 阿野貴弘; 佐藤詩織; 佐藤詩織; GANTULGA Ariunbold; GANTULGA Ariunbold; 蜂屋佑磨; 小熊圭祐; 大野真美子; 堀北哲也; 泉對博
日本獣医学会学術集会講演要旨集, 2018

牛フォーミーウイルスの分離と分離農場における抗体保有状況の調査
蜂屋佑磨; 木村久美子; 小熊圭祐; 大野真美子; 堀北哲也; 泉對博
日本獣医学会学術集会講演要旨集, 2018

地方病性牛白血病の腫瘍細胞における牛白血病ウイルスのゲノム欠損
坂本晏澄香; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2018

ヒトコブラクダと放牧地を共有する家畜の中東呼吸器症候群コロナウイルス(MERS-CoV)抗体保有状況調査
寺道拓郎; 福士秀悦; 蜂屋佑磨; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2018

猫コロナウイルスの7遺伝子群の変異解析
安達友; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2017

若齢EBL発症牛におけるBLVプロウイルス組込み部位の解析
前澤誠希; 小熊圭祐; 泉對博; 長谷部文子; 猪熊壽
日本獣医学会学術集会講演要旨集, 2016

千葉県で捕獲された野生動物のレプトスピラ抗体保有状況調査
坂川達哉; 蜂屋佑磨; 小熊圭祐; 小泉信夫; 菊池直哉; 泉對博
日本獣医学会学術集会講演要旨集, 2016

エチオピアで飼育されている流産歴があるラクダのウイルス性疾病の抗体調査
MELAKU Simenew Keskes; 蜂屋佑磨; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2016

猫伝染性腹膜炎ウイルスのスパイク遺伝子の変異解析
大野恵; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2016

A clinical case of enzootic bovine leukosis with BLV-provirus monoclonal integration in 21-month-old Japanese Black beef cattle
Maezawa M; Kayou S; Miura S; Oguma K; Sentsui H; Horiuchi N; Kobayashi Y; Furuoka H; Inokuma H
Jpn. J. Large Anim. Clin., 2016, Not refereed, Not invited

Survey on vertical infection of bovine viral diarrhea virus from fetal bovine sera in the field
Kumiko Nagayama; Keisuke Oguma; Hiroshi Sentsui
JOURNAL OF VETERINARY MEDICAL SCIENCE, Nov. 2015, Refereed, Not invited

野生イノシシの豚流行性下痢ウイルス抗体保有状況の調査
小林英美; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2015

中東呼吸器症候群コロナウイルス(MERS-CoV)抗体検出法の検討
蜂屋佑磨; 白戸憲也; 松山州徳; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2015

マエディ・ビスナウイルス持続感染株化細胞の作製
鈴木和也; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2015

BLVプロウイルス単クローン性組込みが証明された21カ月齢黒毛和種肥育牛の地方病性牛白血病
前澤誠希; 嘉陽静香; 三浦沙織; 三浦沙織; 小熊圭祐; 泉對博; 猪熊壽
産業動物臨床医学雑誌, 2015

2カ月齢の子牛に発生した地方病性牛白血病症例の解析
小熊圭祐; 泉對博
Twig’s, 2015

Distribution and characteristics of bovine leukemia virus integration sites in the host genome at three different clinical stages of infection
T. Miyasaka; K. Oguma; H. Sentsui
ARCHIVES OF VIROLOGY, Jan. 2015, Refereed, Not invited

牛パラインフルエンザ3型(BPIV-3)の胎盤感染に関する調査
永山矩美子; 小熊圭祐; 村上裕信; 佐藤礼一郎; 長井誠; 白井淳資; 泉對博
日本獣医学会学術集会講演要旨集, 2014

2カ月齢の子牛に発生した地方病型牛白血病
小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2014

千葉県野生イノシシのレプトスピラおよびE型肝炎感染状況
蜂屋佑磨; 佐藤隆裕; 小熊圭祐; 泉對博
Twig’s, 2014

岩手県で飼育されていた緬羊からのマエディ・ビスナウイルス分離
小熊圭祐; 田中千晶; 泉對博
Twig’s, 2014

野生ハクビシンのウイルス感染状況およびProtein A/Gを使用した酵素抗体法の開発
齋藤理乃; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2013

牛白血病ウイルスの各病態における宿主ゲノム内組込み位置の分布
宮坂卓; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2013

組換え犬インターフェロンγの抗ウイルス作用
松本和歌音; 小熊圭祐; 前田健; 泉對博
日本獣医学会学術集会講演要旨集, 2013

ネコTRIM遺伝子の同定とレトロウイルス感染制御作用の解明
木庭猟達; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2013

千葉県に生息するイノシシにおけるレプトスピラ感染状況の調査
蜂屋佑磨; 木庭猟達; 小熊圭祐; 佐藤隆裕; 倉地充; 泉對博
日本獣医学会学術集会講演要旨集, 2013

牛白血病ウイルスの細胞内侵入経路の探索
宮坂卓; 木庭猟達; 濱田和也; 高安真央; 水村さやか; 小熊圭祐; 村上賢二; 泉對博
日本ウイルス学会学術集会プログラム・抄録集, 2013

ネコTRIM遺伝子の同定およびレトロウイルス感染制御メカニズムの解明
木庭猟達; 小熊圭祐; 泉對博
日本ウイルス学会学術集会プログラム・抄録集, 2013

光感受性物質フェオフォーバイドによる抗ウイルス作用機序の解析
高橋身和; 岩本智恵子; 木庭猟達; 小熊圭祐; 斎藤明義; 小林正美; 泉對博
日本獣医学会学術集会講演要旨集, 2012

SV40遺伝子導入により作製した馬腎臓由来株化細胞と各種馬由来培養細胞のウイルス感受性比較
小熊圭祐; 石田扇子; 木庭猟達; 前田健; 泉對博
日本獣医学会学術集会講演要旨集, 2012

牛白血病ウイルスの宿主ゲノム内組込み位置と病態との関連
宮坂卓; 小熊圭祐; 泉對博
日本ウイルス学会学術集会プログラム・抄録集, 2012

国内で飼育されている羊からのVisna/maedi virus分離
田中千晶; 小熊圭祐; 原澤亮; 木村淳; 泉對博
日本獣医学会学術集会講演要旨集, 2012

千葉県に生息する野生アライグマの犬由来ウイルス感染状況の調査
酒田実和; 小熊圭祐; 泉對博
Twig’s, 2012

猫コロナウイルスの赤血球凝集性
住谷更; 望月雅美; 小熊圭祐; 泉對博
Twig’s, 2012

猫コロナウイルスの赤血球凝集性
住谷更; 望月雅美; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2011

国内の馬に感染しているコロナウイルスの血清学的多様性
池田一真; 山田育代; 菅野徹; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2011

ネコにおけるTRIMの性状解析
藤崎玄徳; 木庭猟達; 小鍛冶知華; 小熊圭祐; 泉對博
日本獣医学会学術集会講演要旨集, 2011

Recruitment of tumor-associated macrophages by cooperation of PGE(2) pathway and infectious stimulation
Hiroko Oshima; Keisuke Oguma; Masanobu Oshima
CANCER RESEARCH, Apr. 2010, Not refereed, Not invited

Activated macrophages promote Wnt/\#946;-catenin signaling activity in gastric epithelial cells through TNF-\#945;
Keisuke Oguma; Hiroko Oshima; Masahiro Aoki; Makoto Taketo; Masanobu Oshima
CANCER RESEARCH, May 2009, Not refereed, Not invited

感染症科診療パーフェクトガイド,犬・猫・エキゾチック動物
Joint work, DNAウイルス
学窓社, Sep. 2019, Not refereed
9784873627700

Small Animal Dermatology for General Practitioners
Keisuke Oguma, Joint work, ウイルスによる皮膚疾患, Keisuke Oguma
学窓社, Sep. 2014, Not refereed
9784873627465

Jun. 2015 - Present
家畜感染症学会

Jul. 2011 - Present
The Japanese Society of Veterinary Science

May 2007 - Dec. 2018
Japanese Cancer Association

Aug. 2009 - Sep. 2018
The Molecular Biology Society of Japan

猫伝染性腹膜炎ウイルスの病原性を決定づけるSおよび3c遺伝子の役割
日本学術振興会, 科学研究費助成事業 基盤研究(C), Apr. 2023 - Mar. 2026
小熊 圭祐

Study of inhibitory mechanism of feline infectious peritonitis virus proliferation by calcium antagonist
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2021 - 31 Mar. 2024
田中 良和; 落合 和彦; 小熊 圭祐; 佐々木 崇; 古谷 哲也; 手嶋 隆洋

ウイルスゲノムの解析による猫伝染性腹膜炎の遺伝子診断法の確立
Apr. 2015 - Mar. 2018
Keisuke Oguma