博士（医学）, The University of Tokyo, May 2009

Life sciences, Digestive surgery

May 2025 - Present
Jichi Medical University, Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Professor

Jan. 2021 - Present
Department of Digestive Surgery, Nihon University School of Medicine

Apr. 2013 - Dec. 2020
Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo

The University of Tokyo, 医学部, 医学科

★Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma
Hiroharu Yamashita; Yasuyuki Seto; Takeshi Sano; Hiroyasu Makuuchi; Nobutoshi Ando; Mitsuru Sasako; Japanese Gastric Cancer Association and the Japan Esophageal Society
Gastric Cancer, Mar. 2017, Refereed, Not invited
Lead

★Optimal extent of lymph node dissection for Siewert type II esophagogastric junction carcinoma
Hiroharu Yamashita; Hitoshi Katai; Shinji Morita; Makoto Saka; Hirokazu Taniguchi; Takeo Fukagawa
Ann Surg, Aug. 2011, Refereed, Not invited
Lead

★Tissue factor expression is a clinical indicator of lymphatic metastasis and poor prognosis in gastric cancer with intestinal phenotype.
Yamashita H; Kitayama J; Ishikawa M; Nagawa H
J Surg Oncol, Mar. 2007, Refereed, Not invited
Lead

Current status, trends, and controversies in the selection of gastrectomy procedures: Insights from two nationwide questionnaire surveys conducted over a 7‐year interval in Japan
Koji Nakada; Hideyuki Kashiwagi; Shinichi Kinami; Hiroharu Yamashita; Nobuyoshi Hanyu; Atsushi Oshio; Michio Kaminishi; Yasuyuki Seto
Annals of Gastroenterological Surgery, Sep. 2025

Laparoscopic Sleeve Gastrectomy for an Obese Patient with Retroperitoneal Schwannoma: A Case Report
Yuriko Yamada; Shin Saito; Shinichiro Yokota; Yoshinori Hosoya; Hiroharu Yamashita; Hironori Yamaguchi
Surgical Case Reports, 2025

Expression of therapy target molecules in esophagogastric junction and Barrett's adenocarcinoma.
Hiroyuki Abe; Masayuki Urabe; Koichi Yagi; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Dec. 2024

Response to chemotherapy could predict the prognosis of esophageal squamous cell carcinoma treated with neoadjuvant docetaxel, cisplatin, and fluorouracil (DCF) followed by surgery: long-term results in a single institute
Yasuyoshi Sato; Kazuhiko Mori; Shinichiro Atsumi; Kei Sakamoto; Shuichiro Oya; Asami Okamoto; Masayuki Urabe; Yoshiyuki Miwa; Shoh Yajima; Koichi Yagi; Sachiyo Nomura; Hiroharu Yamashita; Yasuyuki Seto
Esophagus, Jul. 2024

Ramucirumab Beyond Disease Progression After Paclitaxel Plus Ramucirumab in Gastric Cancer: A Phase II Trial
YASUYOSHI SATO; HIROHARU YAMASHITA; KOICHI YAGI; SACHIYO NOMURA; YASUYUKI SETO
Anticancer Research, Jun. 2024

Alterations in Intratumoral Immune Response before and during Early-On Nivolumab Treatment for Unresectable Advanced or Recurrent Gastric Cancer.
Yasuyoshi Sato; Hiroharu Yamashita; Yukari Kobayashi; Koji Nagaoka; Tetsuro Hisayoshi; Takuya Kawahara; Akihiro Kuroda; Noriyuki Saito; Ryohei Iwata; Yasuhiro Okumura; Koichi Yagi; Susumu Aiko; Sachiyo Nomura; Kazuhiro Kakimi; Yasuyuki Seto
International journal of molecular sciences, Nov. 2023

Prevalence of preoperative asymptomatic deep vein thrombosis in patients undergoing elective general surgery for benign disease
Ken Hagiwara; Yutaka Watanabe; Takeki Suzuki; Yukiyasu Okamura; Hiroharu Yamashita
Annals of Gastroenterological Surgery, Nov. 2023

Current status of gastrectomy and reconstruction types for patients with proximal gastric cancer in Japan
Hiroharu Yamashita; Kazuhiro Toyota; Chikara Kunisaki; Akiyoshi Seshimo; Tsuyoshi Etoh; Ryo Ogawa; Hideo Baba; Koichi Demura; Sachiko Kaida; Atsushi Oshio; Koji Nakada
Asian Journal of Surgery, Oct. 2023

Lymphatic flow mapping using near-infrared fluorescence imaging with indocyanine green helps to predict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junction cancer not treated with neoadjuvant chemotherapy
Shinichiro Shiomi; Koichi Yagi; Ryohei Iwata; Shoh Yajima; Yasuhiro Okumura; Susumu Aikou; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
Surgical Endoscopy, Aug. 2023, Refereed, Not invited

Iatrogenic cervical esophageal perforation: Avoid entering behind a fold in the pyriform sinus
Hiroshi Suda; Ryohei Iwata; Ken Hagiwara; Hiroharu Yamashita
Advances in Digestive Medicine, Jun. 2023

PD-L1 and HLA-class I expression status and their therapeutic implication in oesophageal small-cell carcinoma.
Satoshi Yamashita; Hiroyuki Abe; Hiroharu Yamashita; Koichi Yagi; Yasuyuki Seto; Tetsuo Ushiku
Histopathology, Apr. 2023

Loss of Viral Genome with Altered Immune Microenvironment During Tumour Progression of Epstein-Barr Virus-Associated Gastric Carcinoma.
Atsushi Kondo; Aya Shinozaki-Ushiku; Hirofumi Rokutan; Akiko Kunita; Masako Ikemura; Hiroharu Yamashita; Yasuyuki Seto; Genta Nagae; Kenji Tatsuno; Hiroyuki Aburatani; Daizo Koinuma; Tetsuo Ushiku
The Journal of pathology, Feb. 2023

Signature and Prediction of Perigastric Lymph Node Metastasis in Patients with Gastric Cancer and Total Gastrectomy: Is Total Gastrectomy Always Necessary?
Chun-Dong Zhang; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
Cancers, Jul. 2022

Survival Prediction Capabilities of Preoperative Inflammatory and Nutritional Status in Esophageal Squamous Cell Carcinoma Patients.
Kotaro Sugawara; Koichi Yagi; Yasuhiro Okumura; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
World journal of surgery, Mar. 2022

Universal encoding of pan-cancer histology by deep texture representations.
Daisuke Komura; Akihiro Kawabe; Keisuke Fukuta; Kyohei Sano; Toshikazu Umezaki; Hirotomo Koda; Ryohei Suzuki; Ken Tominaga; Mieko Ochi; Hiroki Konishi; Fumiya Masakado; Noriyuki Saito; Yasuyoshi Sato; Takumi Onoyama; Shu Nishida; Genta Furuya; Hiroto Katoh; Hiroharu Yamashita; Kazuhiro Kakimi; Yasuyuki Seto; Tetsuo Ushiku; Masashi Fukayama; Shumpei Ishikawa
Cell reports, Mar. 2022

Identifying multiple swollen lymph nodes on preoperative computed tomography is associated with poor prognosis along with pathological extensive nodal metastasis in locally advanced gastric cancer.
Motonari Ri; Hiroharu Yamashita; Wataru Gonoi; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Feb. 2022

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy
Muneharu Fujisaki; Takashi Nomura; Hiroharu Yamashita; Yoshikazu Uenosono; Tetsu Fukunaga; Eigo Otsuji; Masahiro Takahashi; Hideo Matsumoto; Atsushi Oshio; Koji Nakada
Journal of Gastric Cancer, 2022

Anomalous vascular anatomy of the left gastric artery in oesophagectomy.
Hiroharu Yamashita
ANZ journal of surgery, Sep. 2021, Refereed, Not invited
Corresponding

胃癌におけるニボルマブ治療前後の腫瘍内免疫応答の解析
佐藤 靖祥; 山下 裕玄; 小林 由香利; 長岡 孝治; 高橋 俊二; 瀬戸 泰之; 垣見 和宏
日本癌学会総会記事, Sep. 2021

Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation
Chun-Dong Zhang; Hideyuki Takeshima; Shigeki Sekine; Satoshi Yamashita; Yu-Yu Liu; Naoko Hattori; Hiroyuki Abe; Hiroharu Yamashita; Masahide Fukuda; Yu Imamura; Tetsuo Ushiku; Hitoshi Katai; Hiroshi Makino; Masayuki Watanabe; Yasuyuki Seto; Toshikazu Ushijima
Gastric Cancer, Sep. 2021, Refereed, Not invited

Human Leukocyte Antigen Class I Deficiency in Gastric Carcinoma: An Adaptive Immune Evasion Strategy Most Common in Microsatellite Instable Tumors
Akiko Iwasaki; Aya Shinozaki-Ushiku; Akiko Kunita; Sho Yamazawa; Yasuyoshi Sato; Hiroharu Yamashita; Masashi Fukayama; Yasuyuki Seto; Tetsuo Ushiku
Am J Surg Pathol, Sep. 2021, Refereed, Not invited

Identifying multiple swollen lymph nodes on preoperative computed tomography is associated with poor prognosis along with pathological extensive nodal metastasis in locally advanced gastric cancer
Motonari Ri; Hiroharu Yamashita; Wataru Gonoi; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
Eur J Surg Oncol, Aug. 2021, Refereed, Not invited

Taxane-based versus platinum-based chemotherapy in early recurrent gastric cancer after radical surgery with S-1 adjuvant chemotherapy: A multi-institutional retrospective analysis
Sakae Nagaoka; Hiroharu Yamashita; Yasuyuki Seto; Muneharu Fujisaki; Norio Mitsumori; Yoko Oshima; Satoshi Yajima; Yoshinori Kikuchi; Koji Otsuka; Masahiko Murakami; Shohei Fujita; Nobue Futawatari; Hideaki Shimada
Asia Pac J Clin Oncol, Jul. 2021, Refereed, Not invited

Prognosis of hemodialysis patients undergoing surgery for gastric cancer: Results of a multicenter retrospective study
Kotaro Sugawara; Hiroharu Yamashita; Satoshi Yajima; Yoko Oshima; Norio Mitsumori; Muneharu Fujisaki; Kimiyasu Yamazaki; Koji Otsuka; Nobue Futawatari; Ryohei Watanabe; Hitoshi Satodate; Yutaro Yoshimoto; Sakae Nagaoka; Jo Tokuyama; Shin Sasaki; Yasuyuki Seto; Hideaki Shimada
Surgery, Jul. 2021, Refereed, Not invited
Corresponding

Geriatric Nutrition Index Influences Survival Outcomes in Gastric Carcinoma Patients Undergoing Radical Surgery
Kotaro Sugawara; Hiroharu Yamashita; Masayuki Urabe; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
J Parenter Enteral Nutr, Jul. 2021, Refereed, Not invited

切除不能進行・再発胃がんにおけるニボルマブ治療前後の腫瘍内免疫環境の解析
小林 由香利; 佐藤 靖祥; 手島 太郎; 奥村 康弘; 八木 浩一; 山下 裕玄; 瀬戸 泰之; 垣見 和宏
日本がん免疫学会総会プログラム・抄録集, May 2021

Risk for lymph node metastasis in Epstein-Barr virus-associated gastric carcinoma with submucosal invasion.
Yosuke Tsuji; Tetsuo Ushiku; Tomohiro Shinozaki; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama; Mitsuhiro Fujishiro; Ichiro Oda; Hitoshi Katai; Hirokazu Taniguchi; Kenkei Hasatani; Yasuharu Kaizaki; Atsunori Oga; Jun Nishikawa; Risaburo Akasaka; Masaki Endo; Tamotsu Sugai; Takayuki Matsumoto; Kazuhiko Koike
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, May 2021, Refereed

Salvage treatment after definitive chemoradiotherapy for esophageal squamous cell carcinoma
Koichi Yagi; Tetsuro Toriumi; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
Ann Gastroenterol Surg, May 2021, Refereed, Not invited

Trunk fat volume can be a predictor of postoperative complications after gastrectomy: a retrospective cohort study
Shinichiro Shiomi; Tetsuro Toriumi; Koichi Yagi; Raito Asaoka; Yasuhiro Okumura; Kotaro Wakamatsu; Susumu Aikou; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
BMC Surg, Apr. 2021, Refereed, Not invited

Comparison of short-term outcomes between transthoracic and robot-assisted transmediastinal radical surgery for esophageal cancer: a prospective study
Shuntaro Yoshimura; Kazuhiko Mori; Motonari Ri; Susumu Aikou; Koichi Yagi; Yukinori Yamagata; Masato Nishida; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
BMC Cancer, Mar. 2021, Refereed, Not invited

免疫ゲノム解析による胃癌の新規免疫学的分類
佐藤 靖祥; 和田 郁雄; 小林 由香利; 奥村 康弘; 若松 高太郎; 八木 浩一; 愛甲 丞; 山下 裕玄; 野村 幸世; 垣見 和宏; 瀬戸 泰之
日本胃癌学会総会記事, Mar. 2021

免疫ゲノム解析による胃癌の新規免疫学的分類
佐藤 靖祥; 和田 郁雄; 小林 由香利; 奥村 康弘; 若松 高太郎; 八木 浩一; 愛甲 丞; 山下 裕玄; 野村 幸世; 垣見 和宏; 瀬戸 泰之
日本胃癌学会総会記事, Mar. 2021

Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis
Pipit Burasakarn; Ryota Higuchi; Souya Nunobe; Shingo Kanaji; Hidetoshi Eguchi; Ken-Ichi Okada; Tsutomu Fujii; Yuichi Nagakawa; Kengo Kanetaka; Hiroharu Yamashita; Suguru Yamada; Shinji Kuroda; Toru Aoyama; Takahiro Akahori; Kenji Nakagawa; Masakazu Yamamoto; Hiroki Yamaue; Masayuki Sho; Yasuhiro Kodera; Japan Duodenal Cancer Guideline Committee
Int J Clin Oncol, Mar. 2021, Refereed, Not invited

Programmed cell death protein 1/programmed death ligand 1 but not HER2 is a potential therapeutic target in gastric neuroendocrine carcinoma
Satoshi Yamashita; Hiroyuki Abe; Akiko Kunita; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku
Histopathology, Feb. 2021, Refereed, Not invited

A phase I study of intraperitoneal paclitaxel combined with gemcitabine plus nab-paclitaxel for pancreatic cancer with peritoneal metastasis
Naminatsu Takahara; Yousuke Nakai; Hironori Ishigami; Kei Saito; Tatsuya Sato; Ryunosuke Hakuta; Kazunaga Ishigaki; Tomotaka Saito; Tsuyoshi Hamada; Suguru Mizuno; Hirofumi Kogure; Hiroharu Yamashita; Hiroyuki Isayama; Yasuyuki Seto; Kazuhiko Koike
Invest New Drugs, Feb. 2021, Refereed, Not invited

The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey
Shinichi Kinami; Masaki Aizawa; Hiroharu Yamashita; Koshi Kumagai; Satoshi Kamiya; Makoto Toda; Takaomi Takahata; Muneharu Fujisaki; Hiroshi Miyamoto; Hiroshi Kusanagi; Kenta Kobayashi; Marie Washio; Kei Hosoda; Takeo Kosaka
Gastric Cancer, Jan. 2021, Refereed, Not invited

Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation
Munetoshi Hinata; Akiko Kunita; Hiroyuki Abe; Yasuyuki Morishita; Kei Sakuma; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku; Masashi Fukayama
Microorganisms, Nov. 2020, Refereed, Not invited

Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor-infiltrating cells
Yasuyoshi Sato; Ikuo Wada; Kosuke Odaira; Akihiro Hosoi; Yukari Kobayashi; Koji Nagaoka; Takahiro Karasaki; Hirokazu Matsushita; Koichi Yagi; Hiroharu Yamashita; Masashi Fujita; Shuichi Watanabe; Takashi Kamatani; Fuyuki Miya; Junichi Mineno; Hidewaki Nakagawa; Tatsuhiko Tsunoda; Shunji Takahashi; Yasuyuki Seto; Kazuhiro Kakimi
Clin Transl Immunology, Oct. 2020, Refereed, Not invited

Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo-carmine dye contrast imaging
Sayaka Nagao; Yosuke Tsuji; Yoshiki Sakaguchi; Yu Takahashi; Chihiro Minatsuki; Keiko Niimi; Hiroharu Yamashita; Nobutake Yamamichi; Yasuyuki Seto; Tomohiro Tada; Kazuhiko Koike
Gastrointest Endosc, Oct. 2020, Refereed, Not invited

Age-dependent survival impact of body mass index in patients with oesophageal squamous cell carcinoma
Kotaro Sugawara; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
Eur J Surg Oncol, Oct. 2020, Refereed, Not invited

Poor nutritional status and sarcopenia influences survival outcomes in gastric carcinoma patients undergoing radical surgery
Kotaro Sugawara; Hiroharu Yamashita; Masayuki Urabe; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
European Journal of Surgical Oncology, Oct. 2020, Refereed, Not invited

One-by-One Comparison of Lymph Nodes Between 18F-FDG Uptake and Pathological Diagnosis in Esophageal Cancer
Shuntaro Yoshimura; Miwako Takahashi; Susumu Aikou; Yasuhiro Okumura; Keiichi Jinbo; Haruna Onoyama; Masayuki Urabe; Koichiro Kawasaki; Koichi Yagi; Masato Nishida; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Keitaro Koyama; Toshimitsu Momose; Hiroyuki Abe; Tetsuo Ushiku; Masashi Fukayama; Yasuyuki Seto
Clin Nucl Med, Oct. 2020, Refereed, Not invited

RNAシーケンス、フローサイトメトリー、免疫染色を用いた胃癌の腫瘍内免疫応答の解析
齋藤 範之; 串原 義啓; 手島 太郎; 孫 長博; 細井 亮宏; 長岡 孝治; 小林 由香利; 佐藤 靖祥; 唐崎 隆弘; 阿部 浩幸; 牛久 哲男; 八木 浩一; 山下 裕玄; 瀬戸 泰之; 垣見 和宏
日本がん免疫学会総会プログラム・抄録集, Sep. 2020

Preoperative restrictive pulmonary dysfunction influences the survival after gastrectomy for elderly patients with gastric carcinoma
Kotaro Sugawara; Hiroharu Yamashita; Sho Yajima; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
Surg Today, Sep. 2020, Refereed, Not invited

What are the important prognostic factors in gastric cancer with positive duodenal margins? A multi-institutional analysis
Shohei Fujita; Yoko Oshima; Satoshi Yajima; Yoshinori Kikuchi; Sakae Nagaoka; Hiroharu Yamashita; Yasuyuki Seto; Muneharu Fujisaki; Norio Mitsumori; Koji Otsuka; Masahiko Murakami; Hidejiro Urakami; Yoh Isobe; Yutaro Yoshimoto; Hitoshi Satodate; Yoshihisa Saida; Hideaki Shimada
Surg Today, Aug. 2020, Refereed, Not invited

Preoperative Exercise Habits are Associated with Post-gastrectomy Complications
Tetsuro Toriumi; Hiroharu Yamashita; Koichiro Kawasaki; Yasuhiro Okumura; Kotaro Wakamatsu; Koichi Yagi; Susumu Aikou; Sachiyo Nomura; Yasuyuki Seto
World J Surg, Aug. 2020, Refereed, Not invited

Associations of Systemic Inflammation and Sarcopenia With Survival of Esophageal Carcinoma Patients
Kotaro Sugawara; Koichi Yagi; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
Ann Thorac Surg, Aug. 2020, Refereed, Not invited

Optimal Definition of Nodal Skip Metastasis in Patients With Esophageal Squamous Cell Carcinoma
Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
Ann Thorac Surg, Aug. 2020, Refereed, Not invited

Preoperative Low Vital Capacity Influences Survival After Esophagectomy for Patients with Esophageal Carcinoma
Kotaro Sugawara; Kazuhiko Mori; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yukari Uemura; Hiroharu Yamashita; Yasuyuki Seto
World J Surg, Jul. 2020, Refereed, Not invited

Pre- and post-operative low prognostic nutritional index influences survival in older patients with gastric carcinoma
Kotaro Sugawara; Susumu Aikou; Sho Yajima; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Koichi Yagi; Hiroharu Yamashita; Yasuyuki Seto
J Geriatr Oncol, Jul. 2020, Refereed, Not invited

Relationships among body composition, muscle strength, and sarcopenia in esophageal squamous cell carcinoma patients
Kotaro Sugawara; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Shuntaro Yoshimura; Koichiro Kawasaki; Asami Tanabe; Susumu Aikou; Yasuyuki Seto
Support Care Cancer, Jun. 2020, Refereed, Not invited

Long-term outcomes of multimodal therapy combining definitive chemoradiotherapy and salvage surgery for T4 esophageal squamous cell carcinoma
Kotaro Sugawara; Koichi Yagi; Yasuhiro Okumura; Masato Nishida; Susumu Aikou; Hiroharu Yamashita; Hideomi Yamashita; Yasuyuki Seto
Int J Clin Oncol, Apr. 2020, Refereed, Not invited

Long-term health-related quality of life following robot-assisted radical transmediastinal esophagectomy
Kotaro Sugawara; Shuntaro Yoshimura; Koichi Yagi; Masato Nishida; Susumu Aikou; Yukinori Yamagata; Kazuhiko Mori; Hiroharu Yamashita; Yasuyuki Seto
Surg Endosc, Apr. 2020, Refereed, Not invited

Perioperative fluid dynamics evaluated by bioelectrical impedance analysis predict infectious surgical complications after esophagectomy
Shuichiro Oya; Hiroharu Yamashita; Ryohei Iwata; Koichiro Kawasaki; Asami Tanabe; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
BMC Surg, Dec. 2019, Refereed, Not invited

Prognostic significance of neutrophil-to-lymphocyte ratio in solid tumors: a note on methodological concerns
Masayuki Urabe; Hiroharu Yamashita; Yasuyuki Seto
Biomark Med, Dec. 2019, Refereed, Invited

Gastric cancer surgery: historical background and perspective in Western countries versus Japan
Chun-Dong Zhang; Hiroharu Yamashita; Yasuyuki Seto
Ann Transl Med, Nov. 2019, Refereed, Not invited
Corresponding

Giant Brunner's gland adenoma of the duodenum manifested by melena
Masayuki Urabe; Hiroharu Yamashita; Masato Nishida; Yasuyuki Seto
ANZ J Surg, Sep. 2019, Refereed, Not invited

Optimal postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by surgery for esophageal carcinoma
Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
J Thorac Dis, Sep. 2019, Refereed, Invited

Gastric cancer with solitary liver metastasis accompanied by cyst formation
Masayuki Urabe; Hiroharu Yamashita; Nobuhisa Akamatsu; Yasuyuki Seto
ANZ J Surg, Jun. 2019, Refereed, Not invited

Preoperative lymph node status on computed tomography influences the survival of pT1b, T2 and T3 esophageal squamous cell carcinoma
Kotaro Sugawara; Hiroharu Yamashita; Yukari Uemura; Koichi Yagi; Masato Nishida; Susumu Aikou; Sachiyo Nomura; Yasuyuki Seto
Surg Today, May 2019, Refereed, Not invited

Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy
Kotaro Sugawara; Kazuhiko Mori; Koichi Yagi; Susumu Aikou; Yukari Uemura; Hiroharu Yamashita; Yasuyuki Seto
Dis Esophagus, Apr. 2019, Refereed, Not invited

Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein-Barr Virus-associated gastric carcinoma
Atsuhito Nakayama; Hiroyuki Abe; Akiko Kunita; Ruri Saito; Teru Kanda; Hiroharu Yamashita; Yasuyuki Seto; Shumpei Ishikawa; Masashi Fukayama
Plos One, Jan. 2019, Refereed, Not invited

A mass-forming cystic appearance of peritoneal recurrence of gastric adenocarcinoma
Ayako Kume; Hiroharu Yamashita; Masato Nishida; Hiroyuki Abe; Masashi Fukayama; Yasuyuki Seto
Journal of Cancer Research and Practice, Dec. 2018

Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy
Kazuyoshi Ohtomo; Reiko Arita; Rika Shirakawa; Tomohiko Usui; Hiroharu Yamashita; Yasuyuki Seto; Satoru Yamagami; TS-1 Multicenter Study Group
Transl Vis Sci Technol, Dec. 2018, Refereed, Not invited

Pregnancy, delivery, and breastfeeding after total gastrectomy for gastric cancer: a case report
Kazuya Higashizono; Sachiyo Nomura; Koichi Yagi; Susumu Aikou; Masato Nishida; Hiroharu Yamashita; Yasuyuki Seto
World J Surg Oncol, Nov. 2018, Refereed, Not invited

Reply to "Nodal skip metastasis may undermine the predictive power of topographic pN classification in esophageal squamous cell carcinoma"
Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
Surgery, Nov. 2018, Refereed, Not invited

Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort
Masayuki Urabe; Tetsuo Ushiku; Aya Shinozaki-Ushiku; Akiko Iwasaki; Sho Yamazawa; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
Cancer Med, Oct. 2018, Refereed, Not invited

Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance
Kosuke Sakitani; Toshihiro Nishizawa; Masahide Arita; Shuntaro Yoshida; Yosuke Kataoka; Daisuke Ohki; Hiroharu Yamashita; Yoshihiro Isomura; Akira Toyoshima; Hidenobu Watanabe; Toshiro Iizuka; Yutaka Saito; Junko Fujisaki; Naohisa Yahagi; Kazuhiko Koike; Osamu Toyoshima
Helicobacter, Aug. 2018, Refereed, Not invited

Reevaluation of laparoscopic versus open distal gastrectomy for early gastric cancer in Asia: A meta-analysis of randomized controlled trials
Chun-Dong Zhang; Hiroharu Yamashita; Shun Zhang; Yasuyuki Seto
Int J Surg, Aug. 2018, Refereed, Not invited

Presentation of oropharyngeal dysphagia and rehabilitative intervention following esophagectomy: a systematic review
A Kaneoka; S Yang; H Inokuchi; R Ueha; H Yamashita; T Nito; Y Seto; N Haga
Dis Esophagus, Aug. 2018, Refereed, Not invited

Mediastinoscopic view of the bronchial arteries in a series of surgical cases evaluated with three-dimensional computed tomography
Kazuhiko Mori; Kenji Ino; Shuntaro Yoshimura; Susumu Aikou; Koichi Yagi; Masato Nishida; Takashi Mitsui; Yasuhiro Okumura; Yukinori Yamagata; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
Esophagus, Jul. 2018, Refereed, Not invited

Quality of life after robot-assisted transmediastinal radical surgery for esophageal cancer
Shuntaro Yoshimura; Kazuhiko Mori; Yukinori Yamagata; Susumu Aikou; Koichi Yagi; Masato Nishida; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
Surg Endosc, May 2018, Refereed, Not invited

Helicobacter pylori infection in subjects negative for high titer serum antibody
Osamu Toyoshima; Toshihiro Nishizawa; Masahide Arita; Yosuke Kataoka; Kosuke Sakitani; Shuntaro Yoshida; Hiroharu Yamashita; Keisuke Hata; Hidenobu Watanabe; Hidekazu Suzuki
World J Gastroenterol, Apr. 2018, Refereed, Not invited

CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8 +/Foxp3 + T cells
Hiroyuki Abe; Ruri Saito; Takashi Ichimura; Akiko Iwasaki; Sho Yamazawa; Aya Shinozaki-Ushiku; Teppei Morikawa; Tetsuo Ushiku; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
Virchows Arch, Apr. 2018, Refereed, Not invited

Non-linear association between long-term outcome and preoperative neutrophil-to-lymphocyte ratio in patients undergoing curative resection for gastric cancer: a retrospective analysis of 1335 cases in a tetrachotomous manner
Masayuki Urabe; Hiroharu Yamashita; Yukari Uemura; Asami Tanabe; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
Jpn J Clin Oncol, Apr. 2018, Refereed, Not invited

Non-exposed endoscopic wall-inversion surgery for gastrointestinal stromal tumor
Takashi Mitsui; Hiroharu Yamashita; Susumu Aikou; Keiko Niimi; Mitsuhiro Fujishiro; Yasuyuki Seto
Transl Gastroenterol Hepatol, Mar. 2018, Refereed, Invited
Corresponding

Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)
Rihito Kanamaru; Hideyuki Ohzawa; Hideyo Miyato; Shiro Matsumoto; Hidenori Haruta; Kentaro Kurashina; Shin Saito; Yoshinori Hosoya; Hironori Yamaguchi; Hiroharu Yamashita; Yasuyuki Seto; Alan Kawarai Lefor; Naohiro Sata; Joji Kitayama
Sci Rep, Jan. 2018, Refereed, Not invited

Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature
Hirofumi Sonoda; Kazushige Kawai; Hironori Yamaguchi; Koji Murono; Manabu Kaneko; Takeshi Nishikawa; Kensuke Otani; Kazuhito Sasaki; Koji Yasuda; Toshiaki Tanaka; Tomomichi Kiyomatsu; Keisuke Hata; Hiroaki Nozawa; Soichiro Lshihara; Susumu Aikou; Hiroharu Yamashita; Tetsuo Ushiku; Yasuyuki Seto; Masashi Fukayama; Toshiaki Watanabe
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, Dec. 2017, Refereed, Not invited

Efficacy of trastuzumab beyond progression as second-line chemotherapy for HER2-positive advanced gastric cancer
Yasuyoshi Sato; Hiroharu Yamashita; Koichi Yagi; Susumu Aikou; Masato Nishida; Yoshiharu Takenaka; Sachiyo Nomura; Yasuyuki Seto
Gastrointestinal Cancer: Targets and Therapy, Dec. 2017

Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis
Osamu Toyoshima; Chizu Tanikawa; Ryuta Yamamoto; Hidenobu Watanabe; Hiroharu Yamashita; Kosuke Sakitani; Shuntaro Yoshida; Michiaki Kubo; Keitaro Matsuo; Hidemi Ito; Kazuhiko Koike; Yasuyuki Seto; Koichi Matsuda
Oncotarget, Dec. 2017, Refereed, Not invited

Reply to: LODDS or negative to positive lymph nodes ratio?
Hiroharu Yamashita; Jingyu Deng; Han Liang; Yasuyuki Seto
Surgery, Nov. 2017, Refereed, Not invited
Lead

Numeric pathologic lymph node classification shows prognostic superiority to topographic pN classification in esophageal squamous cell carcinoma
Kotaro Sugawara; Hiroharu Yamashita; Yukari Uemura; Takashi Mitsui; Koichi Yagi; Masato Nishida; Susumu Aikou; Kazuhiko Mori; Sachiyo Nomura; Yasuyuki Seto
SURGERY, Oct. 2017, Refereed, Not invited

Feasibility of laparoscopic gastrectomy for elderly gastric cancer patients: meta-analysis of non-randomized controlled studies
Liang Zong; Aiwen Wu; Wenyue Wang; Jingyu Deng; Susumu Aikou; Hiroharu Yamashita; Masahiro Maeda; Masanobu Abe; Duonan Yu; Zhiwei Jiang; Yasuyuki Seto; Jiafu Ji
ONCOTARGET, Aug. 2017, Refereed, Not invited

Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma
Sho Yamazawa; Tetsuo Ushiku; Aya Shinozaki-Ushiku; Akimasa Hayashi; Akiko Iwasaki; Hiroyuki Abe; Amane Tagashira; Hiroharu Yamashita; Yasuyuki Seto; Hiroyuki Aburatani; Masashi Fukayama
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Jul. 2017, Refereed, Not invited

Comparison of Prognostic Abilities Among Preoperative Laboratory Data Indices in Patients with Resectable Gastric and Esophagogastric Junction Adenocarcinoma.
Hiroharu Yamashita
World journal of surgery, Jul. 2017, Refereed, Not invited

Re-evaluating the prognostic validity of the negative to positive lymph node ratio in node-positive gastric cancer patients
Hiroharu Yamashita; Jingyu Deng; Han Liang; Yasuyuki Seto
Surgery (United States), Jun. 2017

Results of a nationwide questionnaire-based survey on nutrition management following gastric cancer resection in Japan.
Hiroharu Yamashita
Surgery today, Jun. 2017, Refereed, Not invited

Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor
Keiko Niimi; Rei Ishibashi; Takashi Mitsui; Susumu Aikou; Shinya Kodashima; Hiroharu Yamashita; Nobutake Yamamichi; Yoshihiro Hirata; Mitsuhiro Fujishiro; Yasuyuki Seto; Kazuhiko Koike
Ann Transl Med, Apr. 2017, Refereed, Not invited

Analysis of glycero-lysophospholipids in gastric cancerous ascites
Shigenobu Emoto; Makoto Kurano; Kuniyuki Kano; Keisuke Matsusaki; Hiroharu Yamashita; Masako Nishikawa; Koji Igarashi; Hitoshi Ikeda; Junken Aoki; Joji Kitayama; Yutaka Yatomi
J Lipid Res, Apr. 2017, Refereed, Not invited

Feasibility of laparoscopic gastrectomy for elderly gastric cancer patients: meta-analysis of non-randomized controlled studies.
Hiroharu Yamashita
Oncotarget, Mar. 2017

Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1(+) immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications
Ruri Saito; Hiroyuki Abe; Akiko Kunita; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
MODERN PATHOLOGY, Mar. 2017, Refereed, Not invited

Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings
Hironori Ishigami; Hironori Yamaguchi; Hiroharu Yamashita; Masahiro Asakage; Joji Kitayama
Gastric Cancer, Mar. 2017, Refereed, Not invited

Updated evidence on endoscopic resection of early gastric cancer from Japan
Mitsuhiro Fujishiro; Shuntaro Yoshida; Rie Matsuda; Akiko Narita; Hiroharu Yamashita; Yasuyuki Seto
Gastric Cancer, Mar. 2017, Refereed, Not invited

Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection
Toshihiro Nishizawa; Hidekazu Suzuki; Kosuke Sakitani; Hiroharu Yamashita; Shuntaro Yoshida; Keisuke Hata; Takamitsu Kanazawa; Naoto Fujiwara; Takanori Kanai; Naohisa Yahagi; Osamu Toyoshima
United European Gastroenterol J, Feb. 2017, Refereed, Not invited

Treatment Strategy for Esophagogastric Junction Carcinoma;Highly Controversial Topic in the Upper Gastrointestinal Malignancy
Hiroharu Yamashita; Yasuyuki Seto
Kyobu geka. The Japanese journal of thoracic surgery, Jan. 2017

Early endoscopic management for early bowel obstruction after gastrectomy: a case report.
Higashizono K; Aikou S; Yagi K; Mori K; Yamashita H; Nomura S; Seto Y
Surg Case Rep, Dec. 2016, Refereed, Not invited

Radical esophagectomy for a 92-year-old woman with granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma: a case report.
Kitani M; Yamagata Y; Tanabe A; Yagi K; Aikou S; Kiyokawa T; Nishida M; Yamashita H; Mori K; Nomura S; Seto Y
Oct. 2016

Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population.
Ishihara R; Oyama T; Abe S; Takahashi H; Ono H; Fujisaki J; Kaise M; Goda K; Kawada K; Koike T; Takeuchi M; Matsuda R; Hirasawa D; Yamada M; Kodaira J; Tanaka M; Omae M; Matsui A; Kanesaka T; Takahashi A
Oct. 2016

Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis.
Takashi Ichimura; Hiroyuki Abe; Teppei Morikawa; Hiroharu Yamashita; Shumpei Ishikawa; Tetsuo Ushiku; Yasuyuki Seto; Masashi Fukayama
Human pathology, Oct. 2016

Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients.
Deng J; Yamashita H; Seto Y; Liang H
Ann Surg Oncol, Oct. 2016, Refereed, Not invited

Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication.
Toyoshima O; Yamaji Y; Yoshida S; Matsumoto S; Yamashita H; Kanazawa T; Hata K
Surg Endosc, Sep. 2016, Refereed, Not invited

How should we define the no. 3b lesser curvature lymph node?
Yamashita H; Yagi K; Seto Y
Gastric Cancer, Sep. 2016, Refereed, Not invited
Lead

Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV
Haruna Onoyama; Mako Kamiya; Yugo Kuriki; Toru Komatsu; Hiroyuki Abe; Yosuke Tsuji; Koichi Yagi; Yukinori Yamagata; Susumu Aikou; Masato Nishida; Kazuhiko Mori; Hiroharu Yamashita; Mitsuhiro Fujishiro; Sachiyo Nomura; Nobuyuki Shimizu; Masashi Fukayama; Kazuhiko Koike; Yasuteru Urano; Yasuyuki Seto
SCIENTIFIC REPORTS, Jun. 2016, Refereed, Not invited

In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.
Hiroyuki Abe; Teppei Morikawa; Ruri Saito; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
Virchows Archiv : an international journal of pathology, May 2016

Glucose metabolism in gastric cancer: The cutting-edge.
Yuan LW; Yamashita H; Seto Y
Feb. 2016

Safety and Effectiveness of Endovenous Laser Ablation Combined With Ligation for Severe Saphenous Varicose Veins in Japanese Patients.
Izumi M; Ikeda Y; Yamashita H; Asaoka Y; Fujishiro M; Shin M; Abo Y
Jan. 2016

Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer.
Urabe M; Yamashita H; Seto Y
Ann Surg, Jan. 2016, Refereed, Not invited

Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings.
Yasuhiro Okumura; Susumu Aikou; Haruna Onoyama; Keiichi Jinbo; Yukinori Yamagata; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Miwako Takahashi; Keitaro Koyama; Toshimitsu Momose; Hiroyuki Abe; Keisuke Matsusaka; Tetsuo Ushiku; Masashi Fukayama; Yasuyuki Seto
World journal of surgical oncology, Dec. 2015, Refereed, Not invited

Video of the Month: A Novel Endoscopic Full-Thickness Resection for Early Gastric Cancer.
Niimi K; Aikou S; Kodashima S; Yagi K; Oya S; Yamaguchi D; Yamashita H; Yamamichi N; Fujishiro M; Koike K; Seto Y
Nov. 2015

Primary adenocarcinoma in the middle thoracic esophagus, which revealed scirrhous-like growth
Masayuki Urabe; Kazuhiko Mori; Masato Nishida; Koichi Yagi; Yukinori Yamagata; Susumu Aikou; Hiroharu Yamashita; Sachiyo Nomura; Aya Shinozaki-Ushiku; Masashi Fukayama; Yasuyuki Seto
Esophagus, Oct. 2015

Diagnosis and treatment of esophagogastric junction cancer
Yasuyuki Seto; Hiroharu Yamashita
Journal of Japanese Society of Gastroenterology, Oct. 2015

Flow Cytometric Quantification of Intraperitoneal Free Tumor Cells is a Useful Biomarker in Gastric Cancer Patients with Peritoneal Metastasis.
Joji Kitayama; Shigenobu Emoto; Hironori Yamaguchi; Hironori Ishigami; Haruna Onoyama; Hiroharu Yamashita; Yasuyuki Seto; Keisuke Matsuzaki; Toshiaki Watanabe
Annals of surgical oncology, Jul. 2015, Refereed, Not invited

Solitary fibrous tumor of the greater omentum, mimicking gastrointestinal stromal tumor of the small intestine: a case report.
Urabe M; Yamagata Y; Aikou S; Mori K; Yamashita H; Nomura S; Shibahara J; Fukayama M; Seto Y
May 2015

Should adenocarcinoma of the esophagogastric junction be classified as esophageal cancer? Limited to Siewert type II, yes.
Yamashita H; Katai H
Mar. 2015

Short-term outcomes of robotic radical esophagectomy for esophageal cancer by a nontransthoracic approach compared with conventional transthoracic surgery.
Mori K; Yamagata Y; Aikou S; Nishida M; Kiyokawa T; Yagi K; Yamashita H; Nomura S; Seto Y
Mar. 2015

Phosphatidylserine-specific Phospholipase A1 (PS-PLA(1)) Expression in Colorectal Cancer Correlates with Tumor Invasion and Hematogenous Metastasis
Yuuki Iida; Eiji Sunami; Hiroharu Yamashita; Masaya Hiyoshi; Soichiro Ishihara; Hironori Yamaguchi; Asuka Inoue; Kumiko Makide; Nelson H. Tsuno; Junken Aoki; Joji Kitayama; Toshiaki Watanabe
ANTICANCER RESEARCH, Mar. 2015, Refereed, Not invited

[Optimal surgical approach for esophagogastric junction carcinoma].
Yamashita H; Seto Y
Jan. 2015

Palliative distal gastrectomy offers no survival benefit over gastrojejunostomy for gastric cancer with outlet obstruction: retrospective analysis of an 11-year experience
Yasuhiro Okumura; Hiroharu Yamashita; Susumu Aikou; Koichi Yagi; Yukinori Yamagata; Masato Nishida; Kazuhiko Mori; Sachiyo Nomura; Joji Kitayama; Toshiaki Watanabe; Yasuyuki Seto
WORLD JOURNAL OF SURGICAL ONCOLOGY, Nov. 2014, Refereed, Not invited

Intravenous and intraperitoneal paclitaxel with S-1 for refractory pancreatic cancer with malignant ascites: an interim analysis.
Takahara N; Isayama H; Nakai Y; Sasaki T; Ishigami H; Yamashita H; Yamaguchi H; Hamada T; Uchino R; Mizuno S; Miyabayashi K; Mohri D; Kawakubo K; Kogure H; Yamamoto N; Sasahira N; Hirano K; Ijichi H; Tateishi K; Tada M
Sep. 2014

Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique
Takashi Mitsui; Keiko Niimi; Hiroharu Yamashita; Osamu Goto; Susumu Aikou; Fumihiko Hatao; Ikuo Wada; Nobuyuki Shimizu; Mitsuhiro Fujishiro; Kazuhiko Koike; Yasuyuki Seto
GASTRIC CANCER, Jul. 2014

Intraperitoneal injection of in vitro expanded V gamma 9V delta 2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer
Ikuo Wada; Hirokazu Matsushita; Shuichi Noji; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Nobuyuki Shimizu; Yasuyuki Seto; Kazuhiro Kakimi
CANCER MEDICINE, Apr. 2014, Refereed, Not invited

CD90(+)CD45(-) intraperitoneal mesothelial-like cells inhibit T cell activation by production of arginase I
Joji Kitayama; Shigenobu Emoto; Hironori Yamaguchi; Hironori Ishigami; Hiroharu Yamashita; Yasuyuki Seto; Keisuke Matsuzaki; Toshiaki Watanabe
CELLULAR IMMUNOLOGY, Mar. 2014, Refereed, Not invited

Salvage gastrectomy after intravenous and intraperitoneal paclitaxel (PTX) administration with oral S-1 for peritoneal dissemination of advanced gastric cancer with malignant ascites.
Joji Kitayama; Hironori Ishigami; Hironori Yamaguchi; Hiroharu Yamashita; Shigenobu Emoto; Shoich Kaisaki; Toshiaki Watanabe
Annals of surgical oncology, Feb. 2014, Refereed, Not invited

HER2 Expression in Carcinomas of the True Cardia (Siewert Type II Esophagogastric Junction Carcinoma)
Hitoshi Katai; Michihiro Ishida; Hiroharu Yamashita; Masaki Ohashi; Shinji Morita; Hiroshi Katayama; Takeo Fukagawa; Ryoji Kushima
WORLD JOURNAL OF SURGERY, Feb. 2014

Poorly differentiated mesenteric carcinoma of unknown primary site detected by abscess formation: case report.
Yukinori Yamagata; Yukari Ando; Keisuke Matsusaka; Hisako Karube; Haruna Onoyama; Susumu Aikou; Hiroharu Yamashita; Kazuhiko Mori; Sachiyo Nomura; Masashi Fukayama; Yasuyuki Seto
World journal of surgical oncology, Jan. 2014, Refereed, Not invited

Flow cytometric quantification of intraperitoneal free tumor cells in patients with peritoneal metastasis.
Joji Kitayama; Shigenobu Emoto; Hironori Yamaguchi; Hironori Ishigami; Takao Kamei; Hiroharu Yamashita; Yasuyuki Seto; Keisuke Matsuzaki; Toshiaki Watanabe
Cytometry. Part B, Clinical cytometry, Jan. 2014, Refereed, Not invited

A phase 2 trial of intravenous and intraperitoneal paclitaxel combined with S-1 for treatment of gastric cancer with macroscopic peritoneal metastasis
Hironori Yamaguchi; Joji Kitayama; Hironori Ishigami; Shigenobu Emoto; Hiroharu Yamashita; Toshiaki Watanabe
CANCER, Sep. 2013, Refereed, Not invited

Flow cytometric quantification of intraperitoneal free tumor cells (FTC) in patients with peritoneal metastasis.
Kitayama J; Emoto S; Yamaguchi H; Ishigami H; Kamei T; Yamashita H; Seto Y; Matsuzaki K; Watanabe T
Aug. 2013

食道癌集学治療における免疫治療の役割
森 和彦; 野地 秀一; 山田 和彦; 山形 幸徳; 垣見 和宏; 松下 博和; 愛甲 丞; 山下 裕玄; 上田 哲也; 和田 郁雄; 清水 伸幸; 野村 幸世; 瀬戸 泰之
日本外科学会雑誌, Mar. 2013

Complications and management of an implanted intraperitoneal access port system for intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis.
Emoto S; Ishigami H; Hidemura A; Yamaguchi H; Yamashita H; Kitayama J; Watanabe T
Nov. 2012

Antitumor effect and pharmacokinetics of intraperitoneal NK105, a nanomicellar paclitaxel formulation for peritoneal dissemination
Shigenobu Emoto; Hironori Yamaguchi; Junko Kishikawa; Hiroharu Yamashita; Hironori Ishigami; Joji Kitayama
CANCER SCIENCE, Jul. 2012, Refereed, Not invited

S-1 plus intravenous and intraperitoneal Paclitaxel for gastric cancer with peritoneal metastasis.
Kitayama J; Ishigami H; Yamaguchi H; Yamashita H; Emoto S; Kaisaki S
May 2012

Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination.
Emoto S; Ishigami H; Yamashita H; Yamaguchi H; Kaisaki S; Kitayama J
Apr. 2012

Frequent development of leptomeningeal carcinomatosis in patients with peritoneal dissemination of gastric cancer
Shigenobu Emoto; Hironori Ishigami; Hironori Yamaguchi; Hiroharu Yamashita; Shoichi Kaisaki; Joji Kitayama
GASTRIC CANCER, Oct. 2011, Refereed, Not invited

Systemic inflammatory response in gastric cancer.
Yamashita H; Katai H
Oct. 2010

Short-term exposure to a 1439-MHz TDMA signal exerts no estrogenic effect in rats.
Yamashita H; Hata K; Yamaguchi H; Tsurita G; Wake K; Watanabe S; Taki M; Ueno S; Nagawa H
Oct. 2010

Isolated abdominal wound recurrence after lymph-node dissection for appendiceal adenocarcinoma.
Yamaguchi H; Ishimaru M; Suzuki H; Yamashita H; Hatanaka K; Uekusa T; Nagawa H
Jan. 2010

Phase II study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer with peritoneal metastasis.
Ishigami H; Kitayama J; Kaisaki S; Hidemura A; Kato M; Otani K; Kamei T; Soma D; Miyato H; Yamashita H; Nagawa H
Jan. 2010

Phase I study of biweekly intravenous paclitaxel plus intraperitoneal cisplatin and paclitaxel for gastric cancer with peritoneal metastasis.
Ishigami H; Kitayama J; Kaisaki S; Yamaguchi H; Yamashita H; Emoto S; Nagawa H
2010

Weekly intravenous and intraperitoneal paclitaxel combined with S-1 for malignant ascites due to advanced gastric cancer.
Kitayama J; Ishigami H; Kaisaki S; Hidemura A; Kato M; Otani K; Kamei T; Soma D; Miyato H; Yamashita H; Nagawa H
2010

Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.
Miyato H; Kitayama J; Yamashita H; Souma D; Asakage M; Yamada J; Nagawa H
Jul. 2009

Intraoperative blood loss is a critical risk factor for peritoneal recurrence after curative resection of advanced gastric cancer.
Kamei T; Kitayama J; Yamashita H; Nagawa H
Jun. 2009

Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response.
Yamashita H; Kitayama J; Taguri M; Nagawa H
Jun. 2009

Chromoendoscopy with indigo carmine dye added to acetic acid in the diagnosis of gastric neoplasia.
Yamashita H; Kitayama J; Nagawa H
Jun. 2009

FDG PET/CT findings of splenic angiosarcoma.
Abe T; Sato M; Okumura T; Shioyama Y; Mochizuki Y; Yamashita H; Saito H; Yoshimi F
Feb. 2009

Phase I pharmacokinetic study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer.
Ishigami H; Kitayama J; Otani K; Kamei T; Soma D; Miyato H; Yamashita H; Hidemura A; Kaisaki S; Nagawa H
2009

Intra-peritoneal administration of paclitaxel with non-animal stabilized hyaluronic acid as a vehicle--a new strategy against peritoneal dissemination of gastric cancer.
Yamada J; Kitayama J; Tsuno NH; Yamashita H; Miyato H; Soma D; Otani K; Kamei T; Ishigami H; Hidemura A; Kaisaki S; Takahashi K; Nagawa H
Dec. 2008

Leptin augments proliferation of breast cancer cells via transactivation of HER2.
Soma D; Kitayama J; Yamashita H; Miyato H; Ishikawa M; Nagawa H
Sep. 2008

Replacement of the common hepatic artery by the left gastric artery: a rare variant in gastric cancer surgery.
Yamashita H; Yoshimi F; Mori K; Mochizuki Y; Nagai H; Ikeda H; Shioyama Y; Yamada K
Aug. 2008

Generation of trypsinogen activation peptide activity in rat isolated pancreatic acini under bombesin stimulation.
Yamashita H; Shinozaki H; Otani T
Mar. 2008

Nuclear translocation of HER-4/c-erbB-4 is significantly correlated with prognosis of esophageal squamous cell carcinoma.
Xu S; Kitayama J; Yamashita H; Souma D; Nagawa H
Jan. 2008

A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model.
Yoneyama S; Okaji Y; Tsuno NH; Kawai K; Yamashita H; Tsuchiya T; Yamada J; Sunami E; Osada T; Kitayama J; Takahashi K; Nagawa H
Dec. 2007

Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Mori K; Kitayama J; Aoki J; Kishi Y; Shida D; Yamashita H; Arai H; Nagawa H
Jul. 2007

Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Ishikawa M; Kitayama J; Yamauchi T; Kadowaki T; Maki T; Miyato H; Yamashita H; Nagawa H
Jul. 2007

Hyaluronic acid is a useful tool for intraoperative sentinel node detection in gastric cancer surgery.
Kitayama J; Ishigami H; Ishikawa M; Yamashita H; Soma D; Miyato H; Nagawa H
Jun. 2007

The suppressive effect of sphingosine 1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins alpha(5)beta(1) and alpha(v)beta(3).
Aoki S; Yatomi Y; Shimosawa T; Yamashita H; Kitayama J; Tsuno NH; Takahashi K; Ozaki Y
Jun. 2007

Endoscopic instillation of indigo carmine dye with acetic acid enables the visualization of distinct margin of superficial gastric lesion; Usefulness in endoscopic treatment and diagnosis of gastric cancer.
Yamashita H; Kitayama J; Ishigami H; Yamada J; Miyato H; Kaisaki S; Nagawa H
Apr. 2007

Complete coverage of in situ aortograft by total omental pedicle flap as the most reliable treatment of aortoesophageal fistula.
Kitayama J; Morota T; Kaisaki S; Nakayama H; Ishigami H; Yamashita H; Ishikawa M; Shibata K; Takamoto S; Nagawa H
Jul. 2006

Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor.
Mori K; Kitayama J; Shida D; Yamashita H; Watanabe T; Nagawa H
May 2006

Multiple gastric tube carcinomas after curative oesophagectomy.
Yamashita H; Kitayama J; Ishigami H; Yamaguchi H; Souma D; Nagano R; Nagawa H
Mar. 2006

Massive postoperative polyuria following total gastrectomy for gastric cancer.
Yamashita H; Ishimaru M; Yamaguchi H; Yamauchi H; Sugiura A; Kitayama J; Nagawa H
2006

Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer.
Yamashita H; Kitayama J; Kanno N; Yatomi Y; Nagawa H
2006

Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer.
Sako A; Kitayama J; Ishikawa M; Yamashita H; Nagawa H
2006

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.
Yamashita H; Kitayama J; Shida D; Yamaguchi H; Mori K; Osada M; Aoki S; Yatomi Y; Takuwa Y; Nagawa H
Jan. 2006

Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.
Yamashita H; Kitayama J; Shida D; Ishikawa M; Hama K; Aoki J; Arai H; Nagawa H
Jan. 2006

Prospective randomized trial comparing Billroth I and Roux-en-Y procedures after distal gastrectomy for gastric carcinoma.
Ishikawa M; Kitayama J; Kaizaki S; Nakayama H; Ishigami H; Fujii S; Suzuki H; Inoue T; Sako A; Asakage M; Yamashita H; Hatono K; Nagawa H
Nov. 2005

Hyperfibrinogenemia is a useful predictor for lymphatic metastasis in human gastric cancer.
Yamashita H; Kitayama J; Nagawa H
Oct. 2005

Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells.
Shida D; Kitayama J; Yamaguchi H; Yamashita H; Mori K; Watanabe T; Nagawa H
Sep. 2005

Intestinal perforation caused by stagnated press-through packages.
Yamaguchi H; Yamashita H; Yamauchi H; Suzuki T; Ishimaru M; Nagawa H
Jun. 2005

Anti-angiogenic properties of plaunotol.
Kawai K; Tsuno NH; Kitayama J; Okaji Y; Yazawa K; Asakage M; Yamashita H; Watanabe T; Takahashi K; Nagawa H
Apr. 2005

Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells.
Shida D; Kitayama J; Yamaguchi H; Yamashita H; Mori K; Watanabe T; Nagawa H
Feb. 2005

Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.
Shida D; Kitayama J; Yamaguchi H; Hama K; Aoki J; Arai H; Yamashita H; Mori K; Sako A; Konishi T; Watanabe T; Sakai T; Suzuki R; Ohta H; Takuwa Y; Nagawa H
Dec. 2004

Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells.
Shida D; Kitayama J; Yamaguchi H; Yamashita H; Mori K; Watanabe T; Yatomi Y; Nagawa H
Nov. 2004

Smallest Todani's type II choledochal cyst.
Yamashita H; Otani T; Shioiri T; Takayama T; Kakiuchi C; Todani T; Makuuchi M
Jul. 2003

Possible associations of rectal carcinoma with Schistosoma japonicum infection and membranous nephropathy: a case report with a review.
Matsuda K; Masaki T; Ishii S; Yamashita H; Watanabe T; Nagawa H; Muto T; Hirata Y; Kimura K; Kojima S
Nov. 1999

胃神経内分泌癌の治療標的分子発現 PD-L1(CPS・TPS)、HLAClass I、TILs、MMR蛋白、HER2の検討
山下 智; 阿部 浩幸; 国田 朱子; 山下 裕玄; 瀬戸 泰之; 牛久 哲男
日本消化器外科学会総会, Jul. 2021

胃・食道神経内分泌癌の治療標的分子発現 PD-L1(CPS・TPS)、HLA-Class I、TILs、MMR蛋白、HER2の検討
山下 智; 阿部 浩幸; 国田 朱子; 山下 裕玄; 瀬戸 泰之; 牛久 哲男
日本内分泌外科学会雑誌, May 2021

【外科医のための-悪性腫瘍補助療法のすべて】食道癌の術前補助療法
八木 浩一; 佐藤 靖祥; 李 基成; 谷島 翔; 奥村 康弘; 平野 康介; 若松 高太郎; 愛甲 丞; 山下 裕玄; 野村 幸世; 瀬戸 泰之
臨床外科, Feb. 2021

食道悪性黒色腫術後、上縦隔・小腸再発に対してニボルマブを投与して奏功した1例
小川 悠樹; 奥村 康弘; 佐藤 靖祥; 小野山 温那; 平野 康介; 若松 高太郎; 八木 浩一; 愛甲 丞; 山下 裕玄; 野村 幸世; 瀬戸 泰之
日本臨床外科学会雑誌, Oct. 2019

進行再発胃癌に対するNivolumabの効果 主たる標的部位別の検討から
山下 裕玄; 佐藤 靖祥; 八木 浩一; 小野山 温那; 奥村 康弘; 平野 康介; 若松 高太郎; 愛甲 丞; 野村 幸世; 瀬戸 泰之
日本癌治療学会学術集会抄録集, Oct. 2019

Survivals in a Phase 1 trial of autologous tumor lysate-pulsed DC vaccination after resection of esophageal cancer
Yasuyoshi Sato; Hirokazu Matsushita; Kotaro Sugawara; Hiroharu Yamashita; Kazuhiko Mori; Kazuhiro Kakimi; Yasuyuki Seto
ANNALS OF ONCOLOGY, Oct. 2017, Not refereed, Not invited

関連消化器癌腹膜播種の病態解明と新たな治療戦略 C57BL/6マウス可移植マウス胃癌細胞株の樹立とその腫瘍形成能、腹膜播種形成能に関わる遺伝子の検討
野村 幸世; 山本 昌美; 松下 博和; 山下 裕玄; 愛甲 丞; 瀬戸 泰之; 垣見 和宏; 立松 正衛; ジェイムズ・ゴールデンリング; 塚本 徹哉
日本消化器外科学会総会, Jul. 2017

Is the transthoracic approach no longer a viable option for Siewert type II esophagogastric junction carcinoma?
Hiroharu Yamashita; Yasuyuki Seto
Translational Gastroenterology and Hepatology, 2016

食道癌に対するDCF療法と活性化自己γδT細胞療法の併用による治療効果の検討
平野 康介; 森 和彦; 山田 和彦; 松下 博和; 垣見 和宏; 山形 幸徳; 愛甲 丞; 山下 裕玄; 野村 幸世; 瀬戸 泰之
日本消化器外科学会総会, Jul. 2014

腹水貯留を伴う治療抵抗性胃癌に対するγδT細胞腹腔内投与治療の第1相臨床試験
和田 郁雄; 松下 博和; 垣見 和宏; 小野山 温那; 李 基成; 奥村 康弘; 谷島 翔; 神保 敬一; 土田 泰昭; 愛甲 丞; 山形 幸徳; 山下 裕玄; 森 和彦; 清水 伸幸; 野村 幸世; 瀬戸 泰之
日本外科学会雑誌, Mar. 2013

Pylorus preserving gastrectomy: historical background and our perspectives
Hiroharu Yamashita; Yasuyuki Seto
China-Japan Webinar: Laparoscopic Function-Preserving Gastrectomy For Middle or Upper Third Gastric Cancer, Jul. 2020, Invited

Laparoscopic distal gastrectomy with D2 lymph node dissection
Hiroharu Yamashita
14th Surgical Society Of Northern Greece Congress, Oct. 2019, Invited

D2 lymph node dissection in gastric cancer -the Japanese perspective-
Hiroharu Yamashita
Shiraz International Surgical Oncology Congress, Nov. 2018, Invited

Optimal extent of surgical resection for adenocarcinoma of the esophagogastric junction
Hiroharu Yamashita; Yasuyuki Seto
Shiraz International Surgical Oncology Congress, Nov. 2018, Invited

食道胃接合部癌に対するNo.3a郭清
山下裕玄,八木浩一,奥村康弘,若松高太郎,愛甲丞,西田正人,小川雅子,野村幸世,瀬戸泰之
第72回手術手技研究会, May 2018

Optimal surgical approach for adenocarcinoma of the esohagogastric junction
Hiroharu Yamashita; Yasuyuki Seto
第90回日本胃癌学会総会, Mar. 2018

Development of human machine interface offering minimally invasive surgery based on current interaction system between surgeons
日本大学, 令和4年度日本大学特別研究, Jul. 2022 - Mar. 2024

exploratory research of gut microbiota-derived metabolites
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 30 Jun. 2017 - 31 Mar. 2019
Fujishiro Mitsuhiro

Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2015 - 31 Mar. 2018
Fujishiro Mitsuhiro

Screening for gut microbiota-derived metabolites that stimulate intestinal stem cells
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2016 - 31 Mar. 2017
Fujishiro Mitsuhiro

Systematization of the mechanism by which plasma irradiation causes cell growth and tumor cell death
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 28 Jun. 2012 - 31 Mar. 2017
SHIMIZU Nobuyuki

Cancer stem cell for peritoneal metastasis in abdominal cavity
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2014
ISHIGAMI Hironori; KITAYAMA Joji; YAMAGUCHI Hironori; YAMASHITA Hiroharu; YAZAWA Kentaro

Role of autophagy in immunoescape of solid tumor
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2014
KITAYAMA JOJI; YAMASHITA Hiroharu; YAMAGUCHI Hironori; KAWAI Kazushige

Development of cisplutium binding hialulonic acid gel as a novel intraperitoneal chemotherapeutic agent for peritoneal dissemination of gastric cancer
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2011 - 2013
YAMAGUCHI Hironori; KITAYAMA Joji; YAMASHITA Hiroharu; ISHIGAMI Hironori; ITOU Taichi