山下 裕玄

医学部 医学科教授

学位

  • 博士(医学), 東京大学大学院医学系研究科, 2009年05月

研究分野

  • ライフサイエンス, 消化器外科学

経歴

  • 2021年01月 - 現在
    日本大学医学部消化器外科
  • 2013年04月 - 2020年12月
    東京大学大学院医学系研究科消化管外科学

学歴

  • 東京大学, 医学部, 医学科

論文

  • ★Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma
    Hiroharu Yamashita; Yasuyuki Seto; Takeshi Sano; Hiroyasu Makuuchi; Nobutoshi Ando; Mitsuru Sasako; Japanese Gastric Cancer Association and the Japan Esophageal Society
    Gastric Cancer, 2017年03月, 査読有り, 通常論文
    筆頭著者
  • ★Optimal extent of lymph node dissection for Siewert type II esophagogastric junction carcinoma
    Hiroharu Yamashita; Hitoshi Katai; Shinji Morita; Makoto Saka; Hirokazu Taniguchi; Takeo Fukagawa
    Ann Surg, 2011年08月, 査読有り, 通常論文
    筆頭著者
  • ★Tissue factor expression is a clinical indicator of lymphatic metastasis and poor prognosis in gastric cancer with intestinal phenotype
    Hiroharu Yamashita; Joji Kitayama; Makoto Ishikawa; Hirokazu Nagawa
    J Surg Oncol, 2007年03月, 査読有り, 通常論文
    筆頭著者
  • Ramucirumab Beyond Disease Progression After Paclitaxel Plus Ramucirumab in Gastric Cancer: A Phase II Trial
    YASUYOSHI SATO; HIROHARU YAMASHITA; KOICHI YAGI; SACHIYO NOMURA; YASUYUKI SETO
    Anticancer Research, 2024年06月
  • Alterations in Intratumoral Immune Response before and during Early-On Nivolumab Treatment for Unresectable Advanced or Recurrent Gastric Cancer.
    Yasuyoshi Sato; Hiroharu Yamashita; Yukari Kobayashi; Koji Nagaoka; Tetsuro Hisayoshi; Takuya Kawahara; Akihiro Kuroda; Noriyuki Saito; Ryohei Iwata; Yasuhiro Okumura; Koichi Yagi; Susumu Aiko; Sachiyo Nomura; Kazuhiro Kakimi; Yasuyuki Seto
    International journal of molecular sciences, 2023年11月
  • PD-L1 and HLA-class I expression status and their therapeutic implication in oesophageal small-cell carcinoma.
    Satoshi Yamashita; Hiroyuki Abe; Hiroharu Yamashita; Koichi Yagi; Yasuyuki Seto; Tetsuo Ushiku
    Histopathology, 2023年04月
  • Anomalous vascular anatomy of the left gastric artery in oesophagectomy
    Hagiwara K; Yamashita H.
    ANZ Journal of Surgery, 2022年05月, 査読有り, 通常論文
    責任著者
  • Universal encoding of pan-cancer histology by deep texture representations.
    Daisuke Komura; Akihiro Kawabe; Keisuke Fukuta; Kyohei Sano; Toshikazu Umezaki; Hirotomo Koda; Ryohei Suzuki; Ken Tominaga; Mieko Ochi; Hiroki Konishi; Fumiya Masakado; Noriyuki Saito; Yasuyoshi Sato; Takumi Onoyama; Shu Nishida; Genta Furuya; Hiroto Katoh; Hiroharu Yamashita; Kazuhiro Kakimi; Yasuyuki Seto; Tetsuo Ushiku; Masashi Fukayama; Shumpei Ishikawa
    Cell reports, 2022年03月
  • 胃癌におけるニボルマブ治療前後の腫瘍内免疫応答の解析
    佐藤 靖祥; 山下 裕玄; 小林 由香利; 長岡 孝治; 高橋 俊二; 瀬戸 泰之; 垣見 和宏
    日本癌学会総会記事, 2021年09月
  • Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation
    Chun-Dong Zhang; Hideyuki Takeshima; Shigeki Sekine; Satoshi Yamashita; Yu-Yu Liu; Naoko Hattori; Hiroyuki Abe; Hiroharu Yamashita; Masahide Fukuda; Yu Imamura; Tetsuo Ushiku; Hitoshi Katai; Hiroshi Makino; Masayuki Watanabe; Yasuyuki Seto; Toshikazu Ushijima
    Gastric Cancer, 2021年09月, 査読有り, 通常論文
  • Human Leukocyte Antigen Class I Deficiency in Gastric Carcinoma: An Adaptive Immune Evasion Strategy Most Common in Microsatellite Instable Tumors
    Akiko Iwasaki; Aya Shinozaki-Ushiku; Akiko Kunita; Sho Yamazawa; Yasuyoshi Sato; Hiroharu Yamashita; Masashi Fukayama; Yasuyuki Seto; Tetsuo Ushiku
    Am J Surg Pathol, 2021年09月, 査読有り, 通常論文
  • Identifying multiple swollen lymph nodes on preoperative computed tomography is associated with poor prognosis along with pathological extensive nodal metastasis in locally advanced gastric cancer
    Motonari Ri; Hiroharu Yamashita; Wataru Gonoi; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Eur J Surg Oncol, 2021年08月, 査読有り, 通常論文
  • Taxane-based versus platinum-based chemotherapy in early recurrent gastric cancer after radical surgery with S-1 adjuvant chemotherapy: A multi-institutional retrospective analysis
    Sakae Nagaoka; Hiroharu Yamashita; Yasuyuki Seto; Muneharu Fujisaki; Norio Mitsumori; Yoko Oshima; Satoshi Yajima; Yoshinori Kikuchi; Koji Otsuka; Masahiko Murakami; Shohei Fujita; Nobue Futawatari; Hideaki Shimada
    Asia Pac J Clin Oncol, 2021年07月, 査読有り, 通常論文
  • Prognosis of hemodialysis patients undergoing surgery for gastric cancer: Results of a multicenter retrospective study
    Kotaro Sugawara; Hiroharu Yamashita; Satoshi Yajima; Yoko Oshima; Norio Mitsumori; Muneharu Fujisaki; Kimiyasu Yamazaki; Koji Otsuka; Nobue Futawatari; Ryohei Watanabe; Hitoshi Satodate; Yutaro Yoshimoto; Sakae Nagaoka; Jo Tokuyama; Shin Sasaki; Yasuyuki Seto; Hideaki Shimada
    Surgery, 2021年07月, 査読有り, 通常論文
    責任著者
  • Geriatric Nutrition Index Influences Survival Outcomes in Gastric Carcinoma Patients Undergoing Radical Surgery
    Kotaro Sugawara; Hiroharu Yamashita; Masayuki Urabe; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    J Parenter Enteral Nutr, 2021年07月, 査読有り, 通常論文
  • Salvage treatment after definitive chemoradiotherapy for esophageal squamous cell carcinoma
    Koichi Yagi; Tetsuro Toriumi; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
    Ann Gastroenterol Surg, 2021年05月, 査読有り, 通常論文
  • Trunk fat volume can be a predictor of postoperative complications after gastrectomy: a retrospective cohort study
    Shinichiro Shiomi; Tetsuro Toriumi; Koichi Yagi; Raito Asaoka; Yasuhiro Okumura; Kotaro Wakamatsu; Susumu Aikou; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    BMC Surg, 2021年04月, 査読有り, 通常論文
  • Comparison of short-term outcomes between transthoracic and robot-assisted transmediastinal radical surgery for esophageal cancer: a prospective study
    Shuntaro Yoshimura; Kazuhiko Mori; Motonari Ri; Susumu Aikou; Koichi Yagi; Yukinori Yamagata; Masato Nishida; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    BMC Cancer, 2021年03月, 査読有り, 通常論文
  • Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis
    Pipit Burasakarn; Ryota Higuchi; Souya Nunobe; Shingo Kanaji; Hidetoshi Eguchi; Ken-Ichi Okada; Tsutomu Fujii; Yuichi Nagakawa; Kengo Kanetaka; Hiroharu Yamashita; Suguru Yamada; Shinji Kuroda; Toru Aoyama; Takahiro Akahori; Kenji Nakagawa; Masakazu Yamamoto; Hiroki Yamaue; Masayuki Sho; Yasuhiro Kodera; Japan Duodenal Cancer Guideline Committee
    Int J Clin Oncol, 2021年03月, 査読有り, 通常論文
  • Programmed cell death protein 1/programmed death ligand 1 but not HER2 is a potential therapeutic target in gastric neuroendocrine carcinoma
    Satoshi Yamashita; Hiroyuki Abe; Akiko Kunita; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku
    Histopathology, 2021年02月, 査読有り, 通常論文
  • A phase I study of intraperitoneal paclitaxel combined with gemcitabine plus nab-paclitaxel for pancreatic cancer with peritoneal metastasis
    Naminatsu Takahara; Yousuke Nakai; Hironori Ishigami; Kei Saito; Tatsuya Sato; Ryunosuke Hakuta; Kazunaga Ishigaki; Tomotaka Saito; Tsuyoshi Hamada; Suguru Mizuno; Hirofumi Kogure; Hiroharu Yamashita; Hiroyuki Isayama; Yasuyuki Seto; Kazuhiko Koike
    Invest New Drugs, 2021年02月, 査読有り, 通常論文
  • The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey
    Shinichi Kinami; Masaki Aizawa; Hiroharu Yamashita; Koshi Kumagai; Satoshi Kamiya; Makoto Toda; Takaomi Takahata; Muneharu Fujisaki; Hiroshi Miyamoto; Hiroshi Kusanagi; Kenta Kobayashi; Marie Washio; Kei Hosoda; Takeo Kosaka
    Gastric Cancer, 2021年01月, 査読有り, 通常論文
  • Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation
    Munetoshi Hinata; Akiko Kunita; Hiroyuki Abe; Yasuyuki Morishita; Kei Sakuma; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku; Masashi Fukayama
    Microorganisms, 2020年11月, 査読有り, 通常論文
  • Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor-infiltrating cells
    Yasuyoshi Sato; Ikuo Wada; Kosuke Odaira; Akihiro Hosoi; Yukari Kobayashi; Koji Nagaoka; Takahiro Karasaki; Hirokazu Matsushita; Koichi Yagi; Hiroharu Yamashita; Masashi Fujita; Shuichi Watanabe; Takashi Kamatani; Fuyuki Miya; Junichi Mineno; Hidewaki Nakagawa; Tatsuhiko Tsunoda; Shunji Takahashi; Yasuyuki Seto; Kazuhiro Kakimi
    Clin Transl Immunology, 2020年10月, 査読有り, 通常論文
  • Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo-carmine dye contrast imaging
    Sayaka Nagao; Yosuke Tsuji; Yoshiki Sakaguchi; Yu Takahashi; Chihiro Minatsuki; Keiko Niimi; Hiroharu Yamashita; Nobutake Yamamichi; Yasuyuki Seto; Tomohiro Tada; Kazuhiko Koike
    Gastrointest Endosc, 2020年10月, 査読有り, 通常論文
  • Age-dependent survival impact of body mass index in patients with oesophageal squamous cell carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Eur J Surg Oncol, 2020年10月, 査読有り, 通常論文
  • Poor nutritional status and sarcopenia influences survival outcomes in gastric carcinoma patients undergoing radical surgery
    Kotaro Sugawara; Hiroharu Yamashita; Masayuki Urabe; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Eur J Surg Oncol, 2020年10月, 査読有り, 通常論文
  • One-by-One Comparison of Lymph Nodes Between 18F-FDG Uptake and Pathological Diagnosis in Esophageal Cancer
    Shuntaro Yoshimura; Miwako Takahashi; Susumu Aikou; Yasuhiro Okumura; Keiichi Jinbo; Haruna Onoyama; Masayuki Urabe; Koichiro Kawasaki; Koichi Yagi; Masato Nishida; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Keitaro Koyama; Toshimitsu Momose; Hiroyuki Abe; Tetsuo Ushiku; Masashi Fukayama; Yasuyuki Seto
    Clin Nucl Med, 2020年10月, 査読有り, 通常論文
  • RNAシーケンス、フローサイトメトリー、免疫染色を用いた胃癌の腫瘍内免疫応答の解析
    齋藤 範之; 串原 義啓; 手島 太郎; 孫 長博; 細井 亮宏; 長岡 孝治; 小林 由香利; 佐藤 靖祥; 唐崎 隆弘; 阿部 浩幸; 牛久 哲男; 八木 浩一; 山下 裕玄; 瀬戸 泰之; 垣見 和宏
    日本がん免疫学会総会プログラム・抄録集, 2020年09月
  • Preoperative restrictive pulmonary dysfunction influences the survival after gastrectomy for elderly patients with gastric carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Sho Yajima; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Surg Today, 2020年09月, 査読有り, 通常論文
  • What are the important prognostic factors in gastric cancer with positive duodenal margins? A multi-institutional analysis
    Shohei Fujita; Yoko Oshima; Satoshi Yajima; Yoshinori Kikuchi; Sakae Nagaoka; Hiroharu Yamashita; Yasuyuki Seto; Muneharu Fujisaki; Norio Mitsumori; Koji Otsuka; Masahiko Murakami; Hidejiro Urakami; Yoh Isobe; Yutaro Yoshimoto; Hitoshi Satodate; Yoshihisa Saida; Hideaki Shimada
    Surg Today, 2020年08月, 査読有り, 通常論文
  • Preoperative Exercise Habits are Associated with Post-gastrectomy Complications
    Tetsuro Toriumi; Hiroharu Yamashita; Koichiro Kawasaki; Yasuhiro Okumura; Kotaro Wakamatsu; Koichi Yagi; Susumu Aikou; Sachiyo Nomura; Yasuyuki Seto
    World J Surg, 2020年08月, 査読有り, 通常論文
  • Associations of Systemic Inflammation and Sarcopenia With Survival of Esophageal Carcinoma Patients
    Kotaro Sugawara; Koichi Yagi; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
    Ann Thorac Surg, 2020年08月, 査読有り, 通常論文
  • Optimal Definition of Nodal Skip Metastasis in Patients With Esophageal Squamous Cell Carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
    Ann Thorac Surg, 2020年08月, 査読有り, 通常論文
  • Preoperative Low Vital Capacity Influences Survival After Esophagectomy for Patients with Esophageal Carcinoma
    Kotaro Sugawara; Kazuhiko Mori; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yukari Uemura; Hiroharu Yamashita; Yasuyuki Seto
    World J Surg, 2020年07月, 査読有り, 通常論文
  • Pre- and post-operative low prognostic nutritional index influences survival in older patients with gastric carcinoma
    Kotaro Sugawara; Susumu Aikou; Sho Yajima; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Koichi Yagi; Hiroharu Yamashita; Yasuyuki Seto
    J Geriatr Oncol, 2020年07月, 査読有り, 通常論文
  • Relationships among body composition, muscle strength, and sarcopenia in esophageal squamous cell carcinoma patients
    Kotaro Sugawara; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Shuntaro Yoshimura; Koichiro Kawasaki; Asami Tanabe; Susumu Aikou; Yasuyuki Seto
    Support Care Cancer, 2020年06月, 査読有り, 通常論文
  • Long-term outcomes of multimodal therapy combining definitive chemoradiotherapy and salvage surgery for T4 esophageal squamous cell carcinoma
    Kotaro Sugawara; Koichi Yagi; Yasuhiro Okumura; Masato Nishida; Susumu Aikou; Hiroharu Yamashita; Hideomi Yamashita; Yasuyuki Seto
    Int J Clin Oncol, 2020年04月, 査読有り, 通常論文
  • Long-term health-related quality of life following robot-assisted radical transmediastinal esophagectomy
    Kotaro Sugawara; Shuntaro Yoshimura; Koichi Yagi; Masato Nishida; Susumu Aikou; Yukinori Yamagata; Kazuhiko Mori; Hiroharu Yamashita; Yasuyuki Seto
    Surg Endosc, 2020年04月, 査読有り, 通常論文
  • Perioperative fluid dynamics evaluated by bioelectrical impedance analysis predict infectious surgical complications after esophagectomy
    Shuichiro Oya; Hiroharu Yamashita; Ryohei Iwata; Koichiro Kawasaki; Asami Tanabe; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    BMC Surg, 2019年12月, 査読有り, 通常論文
  • Prognostic significance of neutrophil-to-lymphocyte ratio in solid tumors: a note on methodological concerns
    Masayuki Urabe; Hiroharu Yamashita; Yasuyuki Seto
    Biomark Med, 2019年12月, 査読有り, 招待有り
  • Gastric cancer surgery: historical background and perspective in Western countries versus Japan
    Chun-Dong Zhang; Hiroharu Yamashita; Yasuyuki Seto
    Ann Transl Med, 2019年11月, 査読有り, 通常論文
    責任著者
  • Giant Brunner's gland adenoma of the duodenum manifested by melena
    Masayuki Urabe; Hiroharu Yamashita; Masato Nishida; Yasuyuki Seto
    ANZ J Surg, 2019年09月, 査読有り, 通常論文
  • Optimal postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by surgery for esophageal carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
    J Thorac Dis, 2019年09月, 査読有り, 招待有り
  • Gastric cancer with solitary liver metastasis accompanied by cyst formation
    Masayuki Urabe; Hiroharu Yamashita; Nobuhisa Akamatsu; Yasuyuki Seto
    ANZ J Surg, 2019年06月, 査読有り, 通常論文
  • Preoperative lymph node status on computed tomography influences the survival of pT1b, T2 and T3 esophageal squamous cell carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yukari Uemura; Koichi Yagi; Masato Nishida; Susumu Aikou; Sachiyo Nomura; Yasuyuki Seto
    Surg Today, 2019年05月, 査読有り, 通常論文
  • Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy
    Kotaro Sugawara; Kazuhiko Mori; Koichi Yagi; Susumu Aikou; Yukari Uemura; Hiroharu Yamashita; Yasuyuki Seto
    Dis Esophagus, 2019年04月, 査読有り, 通常論文
  • Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein-Barr Virus-associated gastric carcinoma
    Atsuhito Nakayama; Hiroyuki Abe; Akiko Kunita; Ruri Saito; Teru Kanda; Hiroharu Yamashita; Yasuyuki Seto; Shumpei Ishikawa; Masashi Fukayama
    Plos One, 2019年01月, 査読有り, 通常論文
  • Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy
    Kazuyoshi Ohtomo; Reiko Arita; Rika Shirakawa; Tomohiko Usui; Hiroharu Yamashita; Yasuyuki Seto; Satoru Yamagami; TS-1 Multicenter Study Group
    Transl Vis Sci Technol, 2018年12月, 査読有り, 通常論文
  • Pregnancy, delivery, and breastfeeding after total gastrectomy for gastric cancer: a case report
    Kazuya Higashizono; Sachiyo Nomura; Koichi Yagi; Susumu Aikou; Masato Nishida; Hiroharu Yamashita; Yasuyuki Seto
    World J Surg Oncol, 2018年11月, 査読有り, 通常論文
  • Reply to "Nodal skip metastasis may undermine the predictive power of topographic pN classification in esophageal squamous cell carcinoma"
    Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
    Surgery, 2018年11月, 査読有り, 通常論文
  • Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort
    Masayuki Urabe; Tetsuo Ushiku; Aya Shinozaki-Ushiku; Akiko Iwasaki; Sho Yamazawa; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    Cancer Med, 2018年10月, 査読有り, 通常論文
  • Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance
    Kosuke Sakitani; Toshihiro Nishizawa; Masahide Arita; Shuntaro Yoshida; Yosuke Kataoka; Daisuke Ohki; Hiroharu Yamashita; Yoshihiro Isomura; Akira Toyoshima; Hidenobu Watanabe; Toshiro Iizuka; Yutaka Saito; Junko Fujisaki; Naohisa Yahagi; Kazuhiko Koike; Osamu Toyoshima
    Helicobacter, 2018年08月, 査読有り, 通常論文
  • Reevaluation of laparoscopic versus open distal gastrectomy for early gastric cancer in Asia: A meta-analysis of randomized controlled trials
    Chun-Dong Zhang; Hiroharu Yamashita; Shun Zhang; Yasuyuki Seto
    Int J Surg, 2018年08月, 査読有り, 通常論文
  • Presentation of oropharyngeal dysphagia and rehabilitative intervention following esophagectomy: a systematic review
    A Kaneoka; S Yang; H Inokuchi; R Ueha; H Yamashita; T Nito; Y Seto; N Haga
    Dis Esophagus, 2018年08月, 査読有り, 通常論文
  • Mediastinoscopic view of the bronchial arteries in a series of surgical cases evaluated with three-dimensional computed tomography
    Kazuhiko Mori; Kenji Ino; Shuntaro Yoshimura; Susumu Aikou; Koichi Yagi; Masato Nishida; Takashi Mitsui; Yasuhiro Okumura; Yukinori Yamagata; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    Esophagus, 2018年07月, 査読有り, 通常論文
  • Quality of life after robot-assisted transmediastinal radical surgery for esophageal cancer
    Shuntaro Yoshimura; Kazuhiko Mori; Yukinori Yamagata; Susumu Aikou; Koichi Yagi; Masato Nishida; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    Surg Endosc, 2018年05月, 査読有り, 通常論文
  • Helicobacter pylori infection in subjects negative for high titer serum antibody
    Osamu Toyoshima; Toshihiro Nishizawa; Masahide Arita; Yosuke Kataoka; Kosuke Sakitani; Shuntaro Yoshida; Hiroharu Yamashita; Keisuke Hata; Hidenobu Watanabe; Hidekazu Suzuki
    World J Gastroenterol, 2018年04月, 査読有り, 通常論文
  • CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8 +/Foxp3 + T cells
    Hiroyuki Abe; Ruri Saito; Takashi Ichimura; Akiko Iwasaki; Sho Yamazawa; Aya Shinozaki-Ushiku; Teppei Morikawa; Tetsuo Ushiku; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    Virchows Arch, 2018年04月, 査読有り, 通常論文
  • Non-linear association between long-term outcome and preoperative neutrophil-to-lymphocyte ratio in patients undergoing curative resection for gastric cancer: a retrospective analysis of 1335 cases in a tetrachotomous manner
    Masayuki Urabe; Hiroharu Yamashita; Yukari Uemura; Asami Tanabe; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Jpn J Clin Oncol, 2018年04月, 査読有り, 通常論文
  • Non-exposed endoscopic wall-inversion surgery for gastrointestinal stromal tumor
    Takashi Mitsui; Hiroharu Yamashita; Susumu Aikou; Keiko Niimi; Mitsuhiro Fujishiro; Yasuyuki Seto
    Transl Gastroenterol Hepatol, 2018年03月, 査読有り, 招待有り
    責任著者
  • Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)
    Rihito Kanamaru; Hideyuki Ohzawa; Hideyo Miyato; Shiro Matsumoto; Hidenori Haruta; Kentaro Kurashina; Shin Saito; Yoshinori Hosoya; Hironori Yamaguchi; Hiroharu Yamashita; Yasuyuki Seto; Alan Kawarai Lefor; Naohiro Sata; Joji Kitayama
    Sci Rep, 2018年01月, 査読有り, 通常論文
  • Comparison of Prognostic Abilities Among Preoperative Laboratory Data Indices in Patients with Resectable Gastric and Esophagogastric Junction Adenocarcinoma
    Masayuki Urabe; Hiroharu Yamashita; Toshiaki Watanabe; Yasuyuki Seto
    World J Surg, 2018年01月, 査読有り, 通常論文
  • Efficacy of trastuzumab beyond progression as second-line chemotherapy for HER2-positive advanced gastric cancer
    Yasuyoshi Sato; Hiroharu Yamashita; Koichi Yagi; Susumu Aikou; Masato Nishida; Yoshiharu Takenaka; Sachiyo Nomura; Yasuyuki Seto
    Gastrointestinal Cancer: Targets and Therapy, 2017年12月
  • Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis
    Osamu Toyoshima; Chizu Tanikawa; Ryuta Yamamoto; Hidenobu Watanabe; Hiroharu Yamashita; Kosuke Sakitani; Shuntaro Yoshida; Michiaki Kubo; Keitaro Matsuo; Hidemi Ito; Kazuhiko Koike; Yasuyuki Seto; Koichi Matsuda
    Oncotarget, 2017年12月, 査読有り, 通常論文
  • Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer
    Masayuki Urabe; Hiroharu Yamashita; Yasuyuki Seto
    Ann Surg, 2017年12月, 査読有り, 通常論文
  • Results of a nationwide questionnaire-based survey on nutrition management following gastric cancer resection in Japan
    Nobuyuki Shimizu; Fumihiko Hatao; Kazuhiko Fukatsu; Susumu Aikou; Yukinori Yamagata; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    Surg Today, 2017年12月, 査読有り, 通常論文
  • Reply to: LODDS or negative to positive lymph nodes ratio?
    Hiroharu Yamashita; Jingyu Deng; Han Liang; Yasuyuki Seto
    Surgery, 2017年11月, 査読有り, 通常論文
    筆頭著者
  • Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma
    Sho Yamazawa; Tetsuo Ushiku; Aya Shinozaki-Ushiku; Akimasa Hayashi; Akiko Iwasaki; Hiroyuki Abe; Amane Tagashira; Hiroharu Yamashita; Yasuyuki Seto; Hiroyuki Aburatani; Masashi Fukayama
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017年07月, 査読有り, 通常論文
  • Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication
    Osamu Toyoshima; Yutaka Yamaji; Shuntaro Yoshida; Shuhei Matsumoto; Hiroharu Yamashita; Takamitsu Kanazawa; Keisuke Hata
    Surg Endosc, 2017年05月, 査読有り, 通常論文
  • How should we define the no. 3b lesser curvature lymph node?
    Hiroharu Yamashita; Koichi Yagi; Yasuyuki Seto
    Gastric Cancer, 2017年05月, 査読有り, 通常論文
    筆頭著者
  • Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor
    Keiko Niimi; Rei Ishibashi; Takashi Mitsui; Susumu Aikou; Shinya Kodashima; Hiroharu Yamashita; Nobutake Yamamichi; Yoshihiro Hirata; Mitsuhiro Fujishiro; Yasuyuki Seto; Kazuhiko Koike
    Ann Transl Med, 2017年04月, 査読有り, 通常論文
  • Analysis of glycero-lysophospholipids in gastric cancerous ascites
    Shigenobu Emoto; Makoto Kurano; Kuniyuki Kano; Keisuke Matsusaki; Hiroharu Yamashita; Masako Nishikawa; Koji Igarashi; Hitoshi Ikeda; Junken Aoki; Joji Kitayama; Yutaka Yatomi
    J Lipid Res, 2017年04月, 査読有り, 通常論文
  • Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1(+) immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications
    Ruri Saito; Hiroyuki Abe; Akiko Kunita; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    MODERN PATHOLOGY, 2017年03月, 査読有り, 通常論文
  • Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings
    Hironori Ishigami; Hironori Yamaguchi; Hiroharu Yamashita; Masahiro Asakage; Joji Kitayama
    Gastric Cancer, 2017年03月, 査読有り, 通常論文
  • Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients
    Jingyu Deng; Hiroharu Yamashita; Yasuyuki Seto; Han Liang
    Ann Surg Oncol, 2017年03月, 査読有り, 通常論文
  • Updated evidence on endoscopic resection of early gastric cancer from Japan
    Mitsuhiro Fujishiro; Shuntaro Yoshida; Rie Matsuda; Akiko Narita; Hiroharu Yamashita; Yasuyuki Seto
    Gastric Cancer, 2017年03月, 査読有り, 通常論文
  • Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection
    Toshihiro Nishizawa; Hidekazu Suzuki; Kosuke Sakitani; Hiroharu Yamashita; Shuntaro Yoshida; Keisuke Hata; Takamitsu Kanazawa; Naoto Fujiwara; Takanori Kanai; Naohisa Yahagi; Osamu Toyoshima
    United European Gastroenterol J, 2017年02月, 査読有り, 通常論文
  • Early endoscopic management for early bowel obstruction after gastrectomy: a case report
    K Higashizono; S Aikou; K Yagi; K Mori; H Yamashita; S Nomura; Y Seto
    Surg Case Rep, 2016年12月, 査読有り, 通常論文
  • Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis.
    Takashi Ichimura; Hiroyuki Abe; Teppei Morikawa; Hiroharu Yamashita; Shumpei Ishikawa; Tetsuo Ushiku; Yasuyuki Seto; Masashi Fukayama
    Human pathology, 2016年10月
  • In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.
    Hiroyuki Abe; Teppei Morikawa; Ruri Saito; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    Virchows Archiv : an international journal of pathology, 2016年05月
  • HER2 Expression in Carcinomas of the True Cardia (Siewert Type II Esophagogastric Junction Carcinoma)
    Hitoshi Katai; Michihiro Ishida; Hiroharu Yamashita; Masaki Ohashi; Shinji Morita; Hiroshi Katayama; Takeo Fukagawa; Ryoji Kushima
    WORLD JOURNAL OF SURGERY, 2014年02月

MISC

  • Survivals in a Phase 1 trial of autologous tumor lysate-pulsed DC vaccination after resection of esophageal cancer
    Yasuyoshi Sato; Hirokazu Matsushita; Kotaro Sugawara; Hiroharu Yamashita; Kazuhiko Mori; Kazuhiro Kakimi; Yasuyuki Seto
    ANNALS OF ONCOLOGY, 2017年10月, 査読無し, 通常論文

講演・口頭発表等

  • Pylorus preserving gastrectomy: historical background and our perspectives
    Hiroharu Yamashita; Yasuyuki Seto
    China-Japan Webinar: Laparoscopic Function-Preserving Gastrectomy For Middle or Upper Third Gastric Cancer, 2020年07月, 招待有り
  • Laparoscopic distal gastrectomy with D2 lymph node dissection
    Hiroharu Yamashita
    14th Surgical Society Of Northern Greece Congress, 2019年10月, 招待有り
  • D2 lymph node dissection in gastric cancer -the Japanese perspective-
    Hiroharu Yamashita
    Shiraz International Surgical Oncology Congress, 2018年11月, 招待有り
  • Optimal extent of surgical resection for adenocarcinoma of the esophagogastric junction
    Hiroharu Yamashita; Yasuyuki Seto
    Shiraz International Surgical Oncology Congress, 2018年11月, 招待有り
  • 食道胃接合部癌に対するNo.3a郭清
    山下裕玄,八木浩一,奥村康弘,若松高太郎,愛甲丞,西田正人,小川雅子,野村幸世,瀬戸泰之
    第72回手術手技研究会, 2018年05月
  • Optimal surgical approach for adenocarcinoma of the esohagogastric junction
    Hiroharu Yamashita; Yasuyuki Seto
    第90回日本胃癌学会総会, 2018年03月

共同研究・競争的資金等の研究課題

  • 執刀医と手術助手のインターラクションに基づいた次世代型手術システムの開発基盤研究
    日本大学, 令和4年度日本大学特別研究, 2022年07月 - 2024年03月
  • 常在性腸内細菌叢由来生理活性代謝産物の探索
    日本学術振興会, 科学研究費助成事業, 2017年06月30日 - 2019年03月31日
    藤城 光弘; 池田 祐一; 熊谷 英敏; 山下 裕玄; 浅岡 良成
  • 新規Wntシグナル制御系を標的とした抗癌剤の開発
    日本学術振興会, 科学研究費助成事業, 2015年04月01日 - 2018年03月31日
    藤城 光弘; 池田 祐一; 熊谷 英敏; 山下 裕玄; 森田 啓行; 浅岡 良成
  • 腸内細菌叢代謝産物から腸管幹細胞増殖刺激因子同定を目指す探索研究
    日本学術振興会, 科学研究費助成事業, 2016年04月01日 - 2017年03月31日
    藤城 光弘; 池田 祐一; 熊谷 英敏; 山下 裕玄; 森田 啓行; 浅岡 良成
  • 分子生物学的解析に基づくプラズマ誘起細胞増殖・腫瘍細胞死誘起メカニズムの体系化
    日本学術振興会, 科学研究費助成事業, 2012年06月28日 - 2017年03月31日
    清水 伸幸; 浜窪 隆雄; 張 京浩; 山下 裕玄
  • 腹膜播種における腹腔内癌幹細胞の同定
    日本学術振興会, 科学研究費助成事業, 2012年04月01日 - 2014年03月31日
    石神 浩徳; 北山 丈二; 山口 博紀; 山下 裕玄; 谷澤 健太郎
  • 固形がんの免疫逃避機構におけるオートファジーの意義
    日本学術振興会, 科学研究費助成事業, 2012年04月01日 - 2014年03月31日
    北山 丈二; 山下 裕玄; 山口 博紀; 川合 一茂
  • 胃癌腹膜播種に対するシスプラチン担持ヒアルロン酸ゲルによる腹腔内化学療法の開発
    日本学術振興会, 科学研究費助成事業, 2011年 - 2013年
    山口 博紀; 北山 丈二; 山下 裕玄; 石神 浩徳; 伊藤 大知