Shibasaki Yasuhiro

College of Bioresource Sciences Department of Marine ScienceAssistant Professor

Research Keyword

  • 胚中心
  • 獲得免疫
  • 比較免疫学
  • 魚類免疫学
  • 抗体産生

Field Of Study

  • Life sciences, Immunology, Comparative Immunology
  • Life sciences, Marine/Aquatic life sciences, Aquatic life science
  • Life sciences, Marine/Aquatic life sciences, 魚類免疫学

Career

  • Apr. 2020 - Present
    日本大学, 生物資源科学部, 助教
  • Apr. 2018 - Mar. 2020
    University of Pennsylvania, 日本学術振興会 海外特別研究員
  • Apr. 2016 - Mar. 2020
    University of Pennsylvania, School of Veterinary medicine, Postdoctoral researcher
  • Apr. 2016 - Mar. 2017
    University of Pennsylvania, 上原記念生命科学研究財団 ポストドクトラルフェロー
  • Oct. 2014 - Mar. 2016
    日本大学, 生物資源学部, ポストドクトラルフェロー
  • Apr. 2012 - Mar. 2014
    日本大学, 日本学術振興会 特別研究員(DC2)

Educational Background

  • 25 Mar. 2014
    日本大学, 獣医学研究科, 獣医学専攻
  • Mar. 2014
    日本大学, 獣医学研究科, 獣医学専攻

Award

  • Aug. 2024
    日本比較免疫学会, 古田優秀論文賞
    柴﨑康宏

Paper

  • 比較免疫学からみたヒトと魚類の抗体の違い
    柴﨑 康宏
    臨床免疫・アレルギー科, May 2024, Refereed, Invited
    Lead
  • Characterization of fish‐specific IFNγ‐related binding with a unique receptor complex and signaling through a novel pathway
    Yasuhiro Shibasaki; Takeshi Yabu; Hajime Shiba; Tadaaki Moritomo; Nobuhiro Mano; Teruyuki Nakanishi
    FEBS Open Bio, Apr. 2024, Refereed
    Lead
  • Cold-blooded vertebrates evolved organized germinal center like structures
    Yasuhiro Shibasaki; Sergei Afanasyev; Alvaro Fernández-Montero; Yang Ding; Shota Watanabe; Fumio Takizawa; Jesús Lamas; Francisco Fontenla; José Manuel Leiro; Aleksei Krasnov; Pierre Boudinot; J. Oriol Sunyer
    Science Immunology, Nov. 2023, Refereed, Not invited
    Lead
  • Secretory IgM (sIgM) is an ancient master regulator of microbiota homeostasis and metabolism
    Yang Ding; Alvaro Fernández-Montero; Amir Mani; Elisa Casadei; Yasuhiro Shibasaki; Fumio Takizawa; Ryuichiro Miyazawa; Irene Salinas; J. Oriol Sunyer
    bioRxiv, Feb. 2023
  • Editorial: Novel techniques to identify immune cell population in fish
    Jia Cai 1; Jianmin Ye; Jorunn Jørgensen; Fumio Takizawa; Yasuhiro Shibasaki
    Frontiers in Immunology, Mar. 2022, Refereed, Invited
  • Alteration of hemoglobin ß gene expression in mucosal tissues of Japanese flounder, Paralichthys olivaceus, in response to heat stress, Edwardsiella piscicida infection, and immunostimulants administration
    Misato Mori; Yasuhiro Shibasaki; Aki Namba; Takeshi Yabu; Noriko Wada; Hajime Shiba; Hirosi Anzai; Nobuhiro Mano
    Fish and Shellfish Immunology Reports, Dec. 2021, Refereed, Invited
  • Enhancement of immune proteins expression in skin mucus of Japanese flounder Paralicthys olivaceus upon feeding a diet supplemented with high concentration of ascorbic acid
    Misato Mori; Tasuku Ito; Ryota Washio; Yasuhiro Shibasaki; Aki Namba; Takeshi Yabu; Dai Iwazaki; Noriko Wada; Hirosi Anzai; Hajime Shiba; Teruyuki Nakanishi; Nobuhiro Mano
    Fish & Shellfish Immunology, Jul. 2021, Refereed
  • Lipoptena fortisetosa as a vector of Bartonella bacteria in Japanese sika deer (Cervus nippon)
    Shingo Sato; Hidenori Kabeya; Sayuri Ishiguro; Yasuhiro Shibasaki; Soichi Maruyama
    Parasites & Vectors, Jan. 2021, Refereed
  • 魚類特有の粘膜抗体IgTの機能解明
    瀧澤 文雄、柴﨑 康宏
    バイオインダストリーとサイエンス, Jan. 2021, Refereed
  • Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution
    Zhen Xu; Fumio Takizawa; Elisa Casadei; Yasuhiro Shibasaki; Yang Ding; Thomas J. C. Sauters; Yongyao Yu; Irene Salinas; J. Oriol Sunyer
    Science Immunology, Feb. 2020, Refereed, Not invited
  • Peculiar Expression of CD3-Epsilon in Kidney of Ginbuna Crucian Carp
    Miyazawa R.; Murata N.; Matsuura Y.; Shibasaki Y.; Yabu T.; Nakanishi T.
    frontiers in immunology, Jun. 2018, Refereed, Not invited
  • Passive immunisation of goldfish with the serum of those surviving a cyprinid herpesvirus 2 infecti on after high temperature water treatment
    Nanjo A.; Shibata T.; Yoshii K.; Shibasaki Y.; Nakanishi T.; Tanaka. M; Kato G.; Sano M.
    Bulletin of the European Association of Fish Pathologists, Sep. 2017, Refereed, Not invited
  • Effects of IFNγ administration on allograft rejection in ginbuna crucian carp
    Shibasaki Y.; Hatanaka C.; Matsuura Y.; Miyazawa R.; Yabu T.; Moritomo T.; Nakanishi T.
    Developmental & Comparative Immunology, Sep. 2016, Refereed, Not invited
  • Cross-reactivity of monoclonal antibodies against CD4-1 and CD8α of ginbuna crucian carp with lymphocytes of zebrafish and other cyprinid species
    Miyazawa R.; Matsuura Y.; Shibasaki Y.; Imamura S.; Nakanishi T.
    Developmental & Comparative Immunology, May 2016, Refereed, Not invited
  • Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea agglomerans
    Inagawa H.; Kobayashi Y.; Kohchi C.; Zhang R.; Shibasaki Y.; Soma G
    In Vivo, May 2016, Refereed, Not invited
  • Recombinant carp IL-4/13B stimulates in vitro proliferation of carp IgM+ B cells
    Yamaguchi T.; Miyata S.; Katakura F.; Nagasawa T.; Shibasaki Y.; Yabu T.; Fischer U.; Nakayasu C.; Nakanishi T.; Moritomo T.
    Fish and Shellfish Immunology, Feb. 2016, Refereed, Not invited
  • Kinetics of lymphocyte subpopulations in allogeneic grafted scales of ginbuna crucian carp
    Shibasaki Y.; Matsuura Y.; Toda H.; Imabayashi N.; Nishino T.; Uzumaki K.; Hatanaka C.; Yabu T.; Moritomo T; Nakanishi T.
    Developmental & Comparative Immunology, Sep. 2015, Refereed, Not invited
    Lead
  • T Cells in Fish
    Nakanishi T.; Shibasaki Y.; Matsuura Y.
    Biology, Sep. 2015, Refereed, Invited
  • Innate immunity activated by oral administration of LPSp is phylogenetically preserved and developed in broiler
    Komori T.; Saito K.; Sawa N.; Shibasaki Y.; Soma G.; Inagawa H.
    Anticancer Research, Aug. 2015, Refereed, Not invited
  • Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling
    Yabu T.; Shiba H.; Shibasaki Y.; Nakanishi T.; Imamura S.; Touhata K.; Yamashita M.
    Cell Death and Differentiation, Feb. 2015, Refereed, Not invited
  • Nayak, S.K., Shibasaki, Y., Nakanishi, T.
    Immune responses to live and inactivated Nocardia seriolae and protective effect of recombinant interferon gamma (rIFN γ) against nocardiosis in ginbuna crucian carp; Carassius auratus langsdorfii
    Fish & Shellfish Immunology, Aug. 2014, Refereed, Not invited
  • Peculiar monomeric interferon gammas, IFNγrel 1 and IFNγrel 2, in ginbuna crucian carp
    Shibasaki Y.; Yabu T.; Araki K.; Mano N.; Shiba H.; Moritomo T; Nakanishi T.
    FEBS Journal, Feb. 2014, Refereed, Not invited
    Lead
  • Antiviral protection mechanisms mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 through two distinct interferon gamma-receptors,
    Yabu T.; Toda H.; Shibasaki Y.; Araki K.; Yamashita M.; Anzai H.; Mano N.; Masuhiro Y.; Hanazawa S.; Shiba H.; Moritomo T.; Nakanishi T.
    Journal of Biochemistry, Dec. 2011, Refereed, Not invited
  • Cytotoxic T cells in teleost fish
    Nakanishi T.; Toda H.; Shibasaki Y.; Somamoto T.
    Developmental & Comparative Immunology, Dec. 2011, Refereed, Invited
  • Kinetics of CD4+ and CD8α+ T-cell subsets in Graft-Versus-Host Reaction (GVHR) in ginbuna crucian carp Carassius auratus langsdorfii
    Shibasaki Y.; Toda H.; Kobayashi I.; Moritomo T.; Nakanishi T.
    Developmental & Comparative Immunology, Oct. 2010, Refereed, Not invited
    Lead
  • Alloantigen -specific killing is mediated by CD8-positive T cells in fish
    Toda H.; Shibasaki Y.; Koike T.; Ohtani M.; Takizawa F.; Ototake M.; Moritomo T.; Nakanishi T.
    Developmental & Comparative Immunology, Apr. 2009, Refereed, Not invited

MISC

  • Conference report: The 14th congress of the International Society of Developmental and Comparative Immunology.
    Abernath K.; Banach M.; Barela Hudgell MA.; Blackmon LE.; Breaux B.; Brusch GA 4th.; Criscitiello MF.; Deiss TC.; Ding Y.; Flowers E.; Kenney E.; Matz H.; Modak T.; Ott J.; Rhoo KH.; Rusnak ED.; Shibasaki Y.; Tassia MG.; Wcisel D.; Yaparla A.
    Developmental & Comparative Immunology, Mar. 2019, Not refereed, Invited
  • Identification and characterization of novel granzyme in fish
    Yuta Matsuura; Takeshi Yabu; Yasuhiro Shibasaki; Hajime Shiba; Tadaaki Moritomo; Teruyuki Nakanishi
    FASEB JOURNAL, Apr. 2014, Not refereed, Not invited
  • Functional characterization of two distinct interferon gamma structurally related protein IFN gamma rel 1 and IFN gamma rel 2, in ginbuna crucian carp
    Yasuhiro Shibasaki; Takeshi Yabu; Tadaaki Moritomo; Teruyuki Nakanishi
    FASEB JOURNAL, Apr. 2012, Not refereed, Not invited
  • Role of fish IFN gamma-related gene in immune system
    Yasuhiro Shibasaki; Takeshi Yabu; Tadaaki Moritomo; Teruyuki Nakanishi
    FASEB JOURNAL, Apr. 2011, Not refereed, Not invited

Books and other publications

  • 実験医学
    柴﨑 康宏; 瀧澤 文雄, Joint work, 変温動物において進化した胚中心様構造
    実験医学・羊土社, May 2024
  • Japanese Scientists in Science Immunology
    Yasuhiro Shibasaki; Fumio Takizawa, Joint work, 冷血脊椎動物において進化した胚中心様構造
    AAAS, Mar. 2024

Lectures, oral presentations, etc.

  • Splenectomy in rainbow trout reduce antigen-specific IgM+ B cells and IgM antibody
    Shota Watanabe; Shunpei Hashiba; Fumio Takizawa; J. Oriol Sunyer; Nobuhiro Mano; Yasuhiro Shibasaki
    15th ISDCI Meeting, Aug. 2023, Not invited
  • Evolution of adaptive immunity: Ancient secondary lymphoid microstructures unveiled in an ectotherm
    Yasuhiro Shibasaki; Sergei Afanasyev; Alvaro Fernández-Montero; Yang Ding; Shota Watanabe; Fumio Takizawa; Jesús Lamas; Francisco Fontenla; José Manuel Leiro; Aleksei Krasnov; Pierre Boudino; J. Oriol Sunyer
    15th ISDCI Meeting, Aug. 2023, Not invited
  • 高濃度アスコルビン酸を経口投与したヒラメ皮膚粘液のプロテオーム解析
    森美里・川野輪和将・永田真由・宮林弘美・渡邉翔太・柴崎康宏・難波亜紀・安齋寛・司馬肇・荻原淳・間野伸宏
    令和4年度日本魚病学会春季大会, Mar. 2022, Not invited
  • 印旛沼流域におけるカミツキガメの摂餌生態(1),―胃内容物に基づく食性分析―
    瀧澤柊介・菅野悠弥・永瀬瞬・柴崎康宏・糸井史朗・間野伸宏・高井則之
    令和4年度日本水産学会春季大会, Mar. 2022
  • 印旛沼流域におけるカミツキガメの摂餌生態(2),―安定同位体比分析―
    高井則之・瀧澤柊介・菅野悠弥・永瀬瞬・柴崎康宏・間野伸宏・桑江朝比呂
    Mar. 2022
  • 森美里・柴崎康宏・難波亜紀・司馬肇・安齋寛・間野伸宏
    ヘモグロビンβ鎖の表皮や鰓組織における発現量は魚類の健康状態の指標となる
    令和3年度魚病学会秋季大会, Sep. 2021, Not invited
  • キンギョのアメーバ性肉芽腫症の病理組織観察
    齋藤桃花・溝口達也・中田結実・大井雄大・柴崎康宏・難波亜紀・間野伸宏・柿崎智広
    令和3年度日本魚病学会秋季大会, Sep. 2021
  • 伝染性造血器壊死症ウイルスの抗原性に関する研究
    杉野御祐・安田秋太・柴崎康宏・難波亜紀・間野伸宏
    令和3年度日本魚病学会秋季大会, Sep. 2021
  • Discovery of cytotoxic killer IgT+ B cells in fish
    Yasuhiro Shibasaki; Fumio Takizawa1; Michael Gonzalez; Pierre Boudinot; J. Oriol Sunyer
    North American Comparative Immunology Workshop, Jun. 2019, Not invited
  • PERFORIN-EXPRESSING IGT+ B CELL WITH CYTOTOXIC ACTIVITY, A NOVEL PLAYER IN THE INNATE IMMUNE RESPONSE OF TELEOST FISH.
    Yasuhiro Shibasaki; Fumio Takizawa; Yang Ding; Pierre Boudinot; J. Oriol Sunyer
    3rd INTERNATIONAL CONFERENCE ON FISH & SHELLFISH IMMUNOLOGY, Jun. 2019, Not invited
  • IDENTIFICATION OF PRIMORDIAL ORGANIZED LYMPHOID STRUCTURE IN THE SPLEEN OF TELEOST FISH.
    Yasuhiro Shibasaki; Fumio Takizawa; Yang Ding; Pierre Boudinot; Aleksei Krasnov; J. Oriol Sunyer
    3rd INTERNATIONAL CONFERENCE ON FISH & SHELLFISH IMMUNOLOGY, Jun. 2019, Not invited
  • PERFORIN-EXPRESSING IGT+ B CELL WITH CYTOTOXIC ACTIVITY, A NOVEL PLAYER IN THE INNATE IMMUNE RESPONSE OF TELEOST FISH.
    Yasuhiro Shibasaki; Fumio Takizawa; Michael Gonzalez; Pierre Boudinot; J. Oriol Sunyer
    International Society for Developmental & Comparative Immunology, Jun. 2018, Not invited
  • Identification of primordial semi-organized lymphoid structures in teleost fish
    Yasuhiro Shibasaki; Fumio Takizawa; Tomas Korytar; Yang Ding Pierre Boudinot; J. Oriol Sunyer
    International Society for Developmental & Comparative Immunology, Jun. 2018, Not invited
  • ギンブナIFNγrelのシグナル伝達機構
    柴崎 康宏、藪 健史、松浦 雄太、難波 亜紀、間野 伸宏、森友 忠昭、中西 照幸
    平成26年度日本水産学会春季大会, Mar. 2014, Not invited
  • 魚類特有のインターフェロン、IFNγrelの機能解析
    柴崎康宏、藪健史、有田希、岡本修太、畑中ちひろ、松浦雄太、山下倫明、森友忠昭、中西照幸
    第86回日本生化学会, Sep. 2013, Not invited
  • 魚類特有の新規インターフェロン、IFNγrelの抗ウイルス活性機構
    柴崎康宏、藪健史、間野伸宏、司馬肇、山下倫明、森友忠昭、中西照幸
    第85回日本生化学会大会, Dec. 2012, Not invited
  • Characterization of interferon gamma structurally related (IFNγrel) isoform 1 and 2 in ginbuna crucian carp, Carassius auratus langsdorfii.
    柴﨑康宏、藪健史、森友忠昭、中西照幸
    2012 ASBMB annual meeting., Apr. 2012, Not invited
  • 魚類特有の新規インターフェロン、IFNγrel 1、およびIFNγrel 2の同定
    柴崎康宏、藪健史、間野伸宏、司馬肇、森友忠昭、中西照幸
    第84回日本生化学会, Sep. 2011, Not invited
  • Characterization of interferon gamma structurally related (IFNγrel) isoform 1 and 2 in ginbuna
    柴崎康宏、藪健史、森友忠昭、中西照幸
    Comparative Immunology and Pathology Workshop Edmonton 2011, May 2011, Not invited
  • Role of fish IFNγ-related gene in immune system.
    柴崎康宏、藪健史、森友忠昭、中西照幸
    2011 ASBMB annual meeting., Apr. 2011, Not invited
  • ギンブナの移植片対宿主反応におけるT細胞サブセットの動態解明
    柴崎康宏 小林功、戸田秀明、森友忠明、中西照幸
    平成21年度日本水産学会春季大会, Mar. 2009, Not invited

Research Themes

  • 魚類抗原特異的抗体の由来と記憶形成のメカニズム
    科学技術振興機構, 創発的研究支援事業, Oct. 2024
  • The impact of feeding ecology of snapping turtle on inland fisheries, analyzed in terms of feeding damage, competition, and fish disease
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2021 - 31 Mar. 2024
    高井 則之; 間野 伸宏; 柴崎 康宏; 桑江 朝比呂
  • Investigation on the source of bacterial cold water disease in rivers
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2021 - 31 Mar. 2024
    間野 伸宏; 高井 則之; 周防 玲; 柴崎 康宏
  • 海外伝染病レッドマウス病をモデルとした魚類の獲得免疫応答の解明
    日本学術振興会, 科学研究費助成事業, 27 Oct. 2020 - 31 Mar. 2024
    瀧澤 文雄; 末武 弘章; 柴崎 康宏; 松浦 雄太
  • 魚類新規インターフェロンIFNγrel受容体の同定及び機能解明
    日本学術振興会, 若手研究(B), Apr. 2015 - Mar. 2016
    柴崎 康宏
  • 新規サイトカインIFNγrelを用いた魚類感染症予防法の開発
    日本学術振興会, 科学研究費助成事業, 2012 - 2013
    柴崎 康宏
  • 感染やワクチン接種に応答して形成される魚類リンパ組織の同定とその特徴
    学術振興会, 研究活動スタート支援
  • 魚類の特異的抗体産生メカニズムを探る

Industrial Property Rights

  • 特許第6614431号, 特願2015-115621, 抗ゼブラフィッシュCD4モノクローナル抗体又は抗体フラグメント、抗ゼブラフィッシュCD8αモノクローナル抗体又は抗体フラグメント及びそれらをコードする核酸
    中西照幸、藪健史、柴崎康宏、松浦雄太、宮澤龍一郎
  • 特開2016-208934, 特願2015-097271, 抗イヌインターロイキン-6受容体モノクローナル抗体又は抗体フラグメント及びその利用
    中西 照幸, 亘 敏広, 枝村 一弥, 藪 健史, 柴崎 康宏, 塩澤 直子