OHSAKI Ayumi

College of Humanities and SciencesProject Professor

Research Keyword

  • ケミカルバイオロジー
  • 創薬化学
  • 有機生物化学
  • 生薬学
  • 天然物化学
  • Natural products
  • bioactive compounds
  • Medicinal plants

Field Of Study

  • Nanotechnology/Materials, Molecular biochemistry, Living Organism Molecular Science

Career

  • Apr. 2024 - Present
    日本大学文理学部, 特任教授
  • Apr. 2021 - Present
    立教大学理学部 兼任教員
  • Apr. 2018 - Mar. 2024
    日本大学文理学部 教授
  • 01 Apr. 2013 - 31 Mar. 2018
    日本大学文理学部化学科 准教授
  • Apr. 2013 - Mar. 2014
    東京医科歯科大学大学院非常勤講師
  • Apr. 2003 - Mar. 2013
    東京医科歯科大学生体材料工学研究所 助教
  • Apr. 2007 - Mar. 2009
    横浜市立大学理学部 非常勤講師
  • Apr. 1999 - Mar. 2003
    東京医科歯科大学生体材料工学研究所 助手
  • Sep. 1992 - Mar. 1999
    東京医科歯科大学医用器材研究所 教務職員
  • Apr. 1987 - Mar. 1991
    近畿大学医学部化学教室 専任講師
  • Apr. 1983 - Mar. 1987
    近畿大学医学部化学教室 助手

Educational Background

  • Mar. 1987
    大阪市立大学大学院, 理学研究科化学専攻 理学博士(論文)取得
  • Apr. 1981 - Mar. 1983
    Osaka City University, Graduate School, Division of Natural Science, Department of Chemistry
  • Apr. 1977 - Mar. 1981
    高知大学理学部化学科

Member History

  • Apr. 2019 - Present
    役員, 香料・テルペンおよび精油化学に関する討論会
  • Nov. 2019 - Oct. 2022
  • 2017 - 2019
    特別研究員等審査会専門委員,卓越研究員・国際事業委員会委員ほか, 日本学術振興会
  • 2014 - 2016
    科学研究費委員会専門委員, 日本学術振興会
  • 2014 - 2015
    総務小委員会委員, 日本化学科第95春季年会

Award

  • 日本化学会年会ポスター賞
    ブラジル産薬用植物に含まれる抗Helicobactor pylori活性物質のフラッシュマイクロアナリシス

Paper

  • Prattinin B: an unusual rosmarinic acid-hybrid meroterpenoid from Salvia prattii
    Hiroshi Kawabe; Kenichi Harada; Yasuko Okamoto; Miwa Kubo; Yoshiyasu Fukuyama; Ryo Hanai; Hiroshi Hirota; Xun Gong; Keiichi Matsuzaki; Ayumi Ohsaki
    Tetrahedron Letters, Apr. 2026, Refereed
    Corresponding
  • Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from Salvia grandifolia
    Hiroshi Kawabe; Teppei Komiyama; Yoshinori Saito; Yasuko Okamoto; Emi Hara; Keiichi Matsuzaki; Motoo Tori; Ryo Hanai; Hiroshi Hirota; Xun Gong; Chiaki Kuroda; Hiroyuki Kagechika; Ayumi Ohsaki
    Journal of Natural Medicines, 2025, Refereed, Not invited
    Corresponding
  • 2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs.
    Kuniko Kusama-Eguchi; Yuki Tokui; Ai Minoura; Yuta Yanai; Dai Hirose; Megumi Furukawa; Yasuhiro Kosuge; Motofumi Miura; Emika Ohkoshi; Mitsuko Makino; Kimino Minagawa; Keiichi Matsuzaki; Yoshio Ogawa; Kazuko Watanabe; Ayumi Ohsaki
    Journal of Natural Medicines, Jan. 2024, Refereed
    Corresponding
  • Anchietins A-E:30-norfriedelane-typetriterpenes form Anchietia pyrifolia
    Yukiyasu Yoneda; Tadahiro Yahagi; Kenichi Harada; Yasuko; Okamoto; Sumiaki; Motai; Keiichi Matsuzaki; Miwa Kubo; Yoshiyasu Fukuyama; Ayumi Ohsaki
    Phytochemistry, 2022, Refereed, Not invited
    Corresponding
  • Germacrane-type sesquiterpenoids from Illicium lanceolatum
    Miwa Kubo; Yuri Nishikawa; Hiroyuki Nakagawa; Shiori Shimada; Ayana Mori; Kenichi Harada; Jian-Mei Huang; Ayumi Ohsaki; Yosyiyasu Fukuyama
    Tetrahedron, 2022, Refereed, Not invited
  • Two Erythrina alkaloids and three diarylpropanoids from Erythrina velutina
    Todoroki; K.; Funasaki; M.; Etoh; Y.; Matuzaki; K.; Ohsaki; A.;
    Tetrahedron, Sep. 2021, Refereed, Not invited
    Corresponding
  • Chemical and genetic diversity of Ligularia kanaitzensis in the Hengduan Moutaines area. Chemical relationship with L. subspicata.
    Ryo Hanai; Yasuko Okamoto; Takuya Hashida; Kosuzu Shiojiri; Ayumi Ohsaki; Yoshinori Saito; Motoo Tori; Xun Gong; Chiaki Kuroda.
    Chemistry & Biodiversity, 2021, Refereed, Not invited
  • 中国横断山脈地域産キク科Ligularia cyathicesのセスキテルペノイド成分
    舟崎真理子,吉川健太,廣田洋,黒田智明,大崎愛弓
    日本大学文理学部自然科学研究所, 2020, Refereed, Not invited
    Corresponding
  • A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions.
    Hidetomo Yokoo; Hiroyuki Kagechika; Ayumi Ohsaki; Tomoya Hirano
    ChemPlusChem, Nov. 2019, Refereed, Not invited
  • Bisabolane, Oplopane, and Lignan Constituents of Cremanthodium campanulatum Collected in China
    Yoshinori Saito; Mayu Ichihara; Koji Takiguchi; Ayumi Ohsaki; Yasuko Okamoto; Chiaki Kuroda; Xun Gong; Motoo Tori
    Natural Product Communications, Jul. 2019, Refereed, Not invited
  • Two new alkaloids from Crinum asiaticum var. japonicum
    Endo; Y.; Sugiura; Y.; Funasaki; M.; Kagechika; H.; Ishibashi; M.; Ohsaki; A.
    J. Nat. Med., 2019, Refereed, Not invited
    Corresponding
  • A. New friedelan triterpenes from Anchietea pyrifolia.
    Funasaki; M.; Minato; C.; Nonaka; M.; Ozawa; M.; Kishida; A.; Ohsaki
    Phytochemistry Lett., 2019, Refereed, Not invited
    Corresponding
  • Sucupiranins M-Q, five new furanocassane-type diterpenoids from the seeds of Bowdichia virgilioides
    Endo; Y.; Kasahara; T.; Asakura; K.; Mori; A.;Funasaki; M.; Akisue; G.; Etoh; T.; Hadara; K.; Fukuyama; Y.; Matsuzaki; K.; Ishibashi; M.; Ohsaki; A.
    Tetrahedron, 2019, Refereed, Not invited
    Corresponding
  • Unique Properties of 1,5-Naphthyridin-2(1H)-one Derivatives as Environment-Polarity-Sensitive Fluorescent Dyes
    Hidetomo Yokoo; Ayumi Ohsaki; Hiroyuki Kagechika; Tomoya Hirano
    European Journal of Organic Chemistry, Feb. 2018, Refereed, Not invited
  • Two new coumarines and a new xanthone from the leaves of Rhizophora mucronata
    Taniguchi; K.; Funasaki; M.; Kishida; A.; Sadhu; S.K.; Ahmed; F.; Ishibashi; M.; Ohsaki; A.
    Bioorg. Med. Chem. Lett., 2018, Refereed, Not invited
    Corresponding
  • Solvent-Free Synthesis of 2-Alkylbenzothiazoles and Bile Acid Derivatives Containing Benzothiazole Ring by Using Active Carbon/Silica Gel and Microwave
    Sakiyama; R.; Aoyama; T.; Akazawa; H.; Kikuchi; N.; Omura; K.; Ohsaki; A.; Yasukawa; K.; Iida; T.; Kodomari; M.
    J. Oleo. Sci.,, 2018, Refereed, Not invited
  • Sucupiranins A-L, Furanocassane Diterpenoids from the Seeds of Bowdichia virgilioides
    Yuta Endo; Taku Kasahara; Kenicni Harada; Miwa Kubo; Tadahiro Etoh; Masami Ishibashi; Aki Ishiyama; Masato Iwatsuki; Kazuhiko Otoguro; Satoshi Omura; Gokithi Akisue; Tomoya Hirano; Hiroyuki Kagechika; Yoshiyasu Fukuyama; Ayumi Ohsaki
    Journal of Natural Products, Dec. 2017, Refereed, Not invited
    Corresponding
  • New Eremophilane-type Sesquiterpenes from Ligularia cymbulifera
    Takahiro Kato; Hiroshi Hirota; Chiaki Kuroda; Xun Gong; Ayumi Ohsaki
    Natural Product Comminucations, Aug. 2017, Refereed, Not invited
    Corresponding
  • Construction of Canthin-5,6-diones via Termolecular Condensation Reaction: Studies on Synthesis of Amarastelline A
    Kenichi Harada; Hiroki Yamane; Miwa Kubo; Ayumi Ohsaki; Yoshiyasu Fukuyama
    Natural Product Communications, Aug. 2017, Refereed, Not invited
  • A New Diterpenoid with a Rearranged Skeleton from Salvia prattii
    Hiroshi Kawabe; Riyo Suzuki; Hiroshi Hirota; Keiichi Matsuzaki; Xun Gong; Ayumi Ohsaki
    Natural Product Communications, Aug. 2017, Refereed, Not invited
    Corresponding
  • Structural development of canthin-5,6-dione moiety as a fluorescent dye and its application to novel fluorescent sensors
    Hidetomo Yokoo; Ayumi Ohsaki; Hiroyuki Kagechika; Tomoya Hirano
    Tetrahedron, Sep. 2016, Refereed, Not invited
  • A New Pimarane-type Diterpenoid from the Seeds of Bowdichia virgilioides
    Miwa Kubo; Misao Uemura; Kenichi Harada; Ayumi Ohsaki; Yoshiyasu Fukuyama
    NATURAL PRODUCT COMMUNICATIONS, Jul. 2016, Refereed, Not invited
  • Two New Diterpenoids from Salvia przewarskii
    Haruka Tsukada; Hiroshi Kawabe; Aya Ohtaka; Yoshinori Saito; Yasuko Okamoto; Motoo Tori; Hiroyuki Kagechika; Hiroshi Hirota; Xun Gong; Chiaki Kuroda; Ayumi Ohsaki
    NATURAL PRODUCT COMMUNICATIONS, Feb. 2016, Refereed, Not invited
    Corresponding
  • 南米産薬用植物Licaria puchury-major種子のアルカロイド成分と薬剤耐性がん細胞に対する殺細胞活性、
    大崎愛弓、宝谷尚徳、小沢正晃、岸田晶夫、小宮山寛機、久保伊佐夫
    日本大学文理学部自然科学研究所研究紀要, Feb. 2015, Refereed, Not invited
    Lead
  • Structures of six new compounds from Ligularia brassicoides
    Yoshinori Saito; Yoko Sasaki; Ayumi Ohsaki; Yasuko Okamoto; Xun Gong; Chiaki Kuroda; Motoo Tori
    Tetrahedron, Dec. 2014, Refereed, Not invited
  • Improved Chemical Synthesis, X-Ray Crystallographic Analysis, and NMR Characterization of (22R)-/(22S)-Hydroxy Epimers of Bile Acids
    Kaoru Omura; Ayumi Ohsaki; Biao Zhou; Manaka Kushida; Takashi Mitsuma; Akiko Kobayashi; Lee R. Hagey; Alan F. Hofmann; Takashi Iida
    LIPIDS, Nov. 2014, Refereed, Not invited
  • A Lanostane Triterpenoid and Three Cholestane Sterols from Tilia kiusiana
    Marie Shimada; Masaaki Ozawa; Kojiro Iwamoto; Yoshiyasu Fukuyama; Akio Kishida; Ayumi Ohsaki
    CHEMICAL & PHARMACEUTICAL BULLETIN, Sep. 2014, Refereed, Not invited
    Corresponding
  • Furanocassane diterpenoids from Bowdichia virgilioides
    Ohsaki; A.; Endo; Y.; Ksahara; T.; Harada; K.; Kubo; M.; Fukuyama; Y.
    Journal of Natural Medicines, Aug. 2014, Refereed, Not invited
    Lead
  • Structure and Cytotoxic Evaluation of 12-Oxygenated Eremophilanes from Ligularia lingiana,
    Saito; Y.; Sasaki; Y.; Komiyama; T.; Ohsaki; A.; Okamoto; Y.; Gong; X.; Kuroda; C.; Tori; M.
    Tetrahedron, Jul. 2014, Refereed, Not invited
  • 中国横断山脈地域に生育するキク科Liguraria属植物の生産するフラノエレモフィラン化合物の多様性
    黒田智明、花井亮、通元夫、岡本育子、齋藤義紀、永野肇、大崎愛弓、廣田洋、川原孝行、Xun GONG.
    有機合成化学協会誌, Jun. 2014, Refereed, Not invited
  • N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): A novel bile acid profile in Perciform fish
    Rika Satoh; Tetsuya Saito; Hiroaki Ogata; Ayumi Ohsaki; Takashi Iida; Kiyoshi Asahina; Kuniko Mitamura; Shigeo Ikegawa; Alan F. Hofmann; Lee R. Hagey
    Steroids, 2014, Refereed, Not invited
  • Four new compounds from Ligularia virgaurea: Isolation of eremophilane and noreremophilane sesquiterpenoids and the absolute configuration of 2α-hydroxyeremophil-11-en-9-one by CD spectrum and DFT calculation
    Yoshinori Saito; Mizuho Taniguchi; Teppei Komiyama; Ayumi Ohsaki; Yasuko Okamoto; Xun Gong; Chiaki Kuroda; Motoo Tori
    Tetrahedron, Sep. 2013, Refereed, Not invited
  • Inhibitory effect of erythraline on toll-like receptor signaling pathway in Raw264.7 cells.
    Etoh. T.; Kim; YP.; Ohsaki; A.; Komiyama; K.; Hayashi; M.
    Biol Pharm Bull, Aug. 2013, Refereed, Not invited
  • The Cytotoxic Activity of Diterpenoids from Isodon species
    Ayumi Ohsaki; Masaaki Ozawa; Kanki Komiyama; Akio Kishida; Takahiko Isobe
    NATURAL PRODUCT COMMUNICATIONS, Aug. 2012, Refereed, Not invited
    Lead
  • Chemical and Genetic Study of Ligularia duciformis and Related Species in Sichuan and Yunnan Provinces of China
    Hajime Nagano; Ryo Hanai; Hiroka Yamada; Mika Matsushima; Yui Miura; Takanori Hoya; Masaaki Ozawa; Miho Fujiwara; Hikari Kodama; Atsushi Torihata; Hiroyuki Onuki; Yoko Nezu; Satoru Kawai; Mizue Yamazaki; Hiroshi Hirota; Yoshinori Saito; Motoo Tori; Ayumi Ohsaki; Xun Gong; Chiaki Kuroda
    CHEMISTRY & BIODIVERSITY, Apr. 2012, Refereed, Not invited
  • Amarastelline A: New fluorescent alkaloid from Quassia amara and its properties in living cells
    Taniguchi; K.; Takizawa; S.; Hirano; T.; Murata; S.; Kagechika; H.; Kishida; A.; Ohsaki; A.
    Chempluschem, Mar. 2012, Refereed, Not invited
    Corresponding
  • Two new norursane-type triterpenoids from Dipsacus chinensis collected in China
    Yoshinori Saito; Yuriko Takashima; Yasuko Okamoto; Teppei Komiyama; Ayumi Ohsaki; Xun Gong; Motoo Tori
    Chemistry Letters, 2012, Refereed, Not invited
  • Erythrinan Alkaloids from Seeds of Erythrina velutina
    Masaaki Ozawa; Akio Kishida; Ayumi Ohsaki
    CHEMICAL & PHARMACEUTICAL BULLETIN, May 2011, Refereed, Not invited
    Corresponding
  • Salviskinone A, a diterpene with a new skeleton from Salvia przewalskii
    Ohsaki A.; Kawamata; S.; Ozawa; M.; Kishida; A.; Gong X.; Kuroda; C.
    Tetrahedron Lett, May 2011, Refereed, Not invited
    Lead
  • Structures of New Erythrinan Alkaloids and Nitric Oxide Production Inhibitors from Erythrina crista-galli
    Masaaki Ozawa; Shunsuke Kawamata; Tadahiro Etoh; Masahiko Hayashi; Kanki Komiyama; Akio Kishida; Chiaki Kuroda; Ayumi Ohsaki
    CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2010, Refereed, Not invited
    Corresponding
  • Brartemisin, an inhibitor of tumor cell invasion from the Actinomycete Nonomurae sp.
    Igarashi; Y.; Mogi; T.; Yanase; S.; Miyanaga; S.; Fujita; T.; Sakurai; H.; Saiki; I.; Ohsaki; A.
    Journal of Natural Products, Aug. 2009, Refereed, Not invited
  • Secu’amamines E-G, new alkaloids from Securinega suffruticosa var.amamiensis
    Ohsaki; A.; Nagaoka; T.; Yoneda; K.; Kishida; A.
    Tetrahedron Lett, Jun. 2009, Refereed, Not invited
    Lead
  • TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina
    Masaaki Ozawa; Tadahiro Etoh; Masahiko Hayashi; Kanki Komiyama; Akio Kishida; Ayumi Ohsaki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jan. 2009, Refereed, Not invited
    Corresponding
  • Hypaphorine, an indole alkaloid from Erythrina velutina, induced sleep on normal mice
    Masaaki Ozawa; Kazuki Honda; Izumi Nakai; Akio Kishida; Ayumi Ohsaki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2008, Refereed, Not invited
    Corresponding
  • Three new Securinega alkaloids from Securinega suffruticosa var. amamiensis
    Ohsaki; A.; Kobayashi; Y.; Yoneda; K.; Kishida; K.; Ishiyama; H.
    Journal of Natural Products, Jun. 2007, Refereed, Not invited
    Lead
  • Biological activity tests of chemical constituents from two Brazilian Labiatae plants
    Takahiko Isobe; Matsumi Doe; Yoshiki Morimoto; Kumiko Nagata; Noriyoshi Masuoka; Ayumi Ohsaki
    Yakugaku Zasshi, Feb. 2007, Refereed, Not invited
    Last
  • New constituents from the leaves of Morinda citrifolia
    Junko Takashima; Yoshitaka Ikeda; Kanki Komiyama; Masahiko Hayashi; Akio Kishida; Ayumi Ohsaki
    CHEMICAL & PHARMACEUTICAL BULLETIN, Feb. 2007, Refereed, Not invited
    Corresponding
  • Two diterpene rhamnosides, mimosasides B and C, from Mimosa hostilis
    Ayumi Ohsaki; Ritsuko Yokoyama; Haruka Miyatake; Yoshiyasu Fukuyama
    CHEMICAL & PHARMACEUTICAL BULLETIN, Dec. 2006, Refereed, Not invited
    Lead
  • Paratunamides A-D, oxindole alkaloids from Cinnamodendron axillare
    Toshinori Kagata; Shizuka Saito; Hideyuki Shigemori; Ayumi Ohsaki; Haruaki Ishiyama; Takaaki Kubota; Jun'ichi Kobayashi
    JOURNAL OF NATURAL PRODUCTS, Oct. 2006, Refereed, Not invited
  • Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration
    S Inatsu; A Ohsaki; K Nagata
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jun. 2006, Refereed, Not invited
  • The anti-Helicobacter pylori flavones in a Brazilian plant, Hyptis fasciculata, and the activity of methoxyflavones
    Takahiko Isobe; Matsumi Doe; Yoshiki Morimoto; Kumiko Nagata; Ayumi Ohsaki
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2006, Refereed, Not invited
    Corresponding
  • New labdane diterpenoids from Hyptis fasciculata
    A Ohsaki; Y Kishimoto; T Isobe; Y Fukuyama
    CHEMICAL & PHARMACEUTICAL BULLETIN, Dec. 2005, Refereed, Not invited
    Lead
  • Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity
    J Takashima; K Komiyama; H Ishiyama; J Kobayashi; A Ohsaki
    PLANTA MEDICA, Jul. 2005, Refereed, Not invited
    Corresponding
  • Two new indole alkaloids from Aspidosperma subincanum and Geissospermum vellosii
    Ishiyama H.; Matsumoto M.; Sekiguchi M.; Shigemori H.; Ohsaki A.; Kobayashi J.
    Heterocycles, May 2005, Refereed, Not invited
  • ジテルペンサイクラーゼ
    有機合成化学協会誌, Sep. 2004, Refereed
    Lead
  • Four new triterpenoids from Maytenus ilicifolia
    A Ohsaki; Y Imai; M Naruse; S Ayabe; K Komiyama; J Takashima
    JOURNAL OF NATURAL PRODUCTS, Mar. 2004, Refereed, Not invited
    Lead
  • ラブダンおよびクレロダンジテルペノイドの構造的多様性と生物活性
    有機合成化学協会誌, Jan. 2004, Refereed, Not invited
    Lead
  • Secu’amamine A, A Novel Indolizidine Alkaloid from Securinega suffruticosa var. amamiensis
    Ohsaki; A.; Ishiyama; H.; Yoneda; K.; Kobayashi; J.
    Tetrahedron Lett, May 2003, Refereed, Not invited
    Lead
  • Naucleamides A-E, new monoterpene indole alkaloids from Nauclea latifolia
    H Shigemori; T Kagata; H Ishiyama; F Morah; A Ohsaki; J Kobayashi
    CHEMICAL & PHARMACEUTICAL BULLETIN, Jan. 2003, Refereed, Not invited
  • Brosimakutins A-I, Nine New Flavonoids from Brosimum acutifolium
    Takashima; J; Ohsaki; A.
    Journal of Natural Products, Dec. 2002, Refereed, Not invited
    Corresponding
  • Subincanadines A-C, novel quaternary indole alkaloids from Aspidosperma subincanum.
    Jun'ichi Kobayashi; Mitsuhiro Sekiguchi; Sayaka Shimamoto; Hideyuki Shigemori; Haruaki Ishiyama; Ayumi Ohsaki
    The Journal of organic chemistry, Sep. 2002, Refereed, Not invited
    Corresponding
  • Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity
    J Takashima; S Asano; A Ohsaki
    PLANTA MEDICA, Jul. 2002, Refereed, Not invited
    Corresponding
  • Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, pariparoba
    T Isobe; A Ohsaki; K Nagata
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2002, Refereed, Not invited
  • Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents
    J Takashima; N Chiba; K Yoneda; A Ohsaki
    Journal of Natural Products, Apr. 2002, Refereed, Not invited
    Corresponding
  • Renealtins A-C, new diarylheptanoids from the seeds of Renealmia exaltata
    Sekiguchi; M.; Shigemori; H.; Ohsaki; A.; Kobayashi; J.
    J Nat Prod, Mar. 2002, Refereed, Not invited
    Corresponding
  • Renealtins A and B, new diarylheptanoids with a tetrahydrofuran ring from the seeds of Renealmia exaltata.
    Mitsuhiro Sekiguchi; Hideyuki Shigemori; Ayumi Ohsaki; Jun'ichi Kobayashi
    Journal of natural products, Mar. 2002, Refereed, Not invited
    Corresponding
  • Echinodolides A and B, new cembrane diterpenoids with an eight-membered lactone ring from the leaves of Echinodorus macrophyllus.
    Hideyuki Shigemori; Sayaka Shimamoto; Mitsuhiro Sekiguchi; Ayumi Ohsaki; Jun'ichi Kobayashi
    Journal of natural products, Jan. 2002, Refereed, Not invited
  • Acutifolins A-F: A new flavan-derived constituent and five new flavans from Brosimum acutifolium
    Takashima; J; Ohsaki; A.
    J Nat Prod, Jun. 2001, Refereed, Not invited
    Corresponding
  • ブラジル産薬用植物Echinodorus macrophyllusより単離したEchinophyllin C〜Fの構造
    繁森 英幸; 関口 光広; 嶌本 沙矢香; 大崎 愛弓; 小林 淳一
    日本薬学会年会要旨集, Mar. 2001
  • Porwenins a and b, new clerodane diterpenoids from portulaca okinawensis
    A. Ohsaki; M. Ogawa; Y. Imai; T. Shinzato; H. Shigemori; J. Kobayashi
    Journal of Natural Products, 2001, Refereed, Not invited
  • Pacovatinins A-C, new labdane diterpenoids from the seeds of Renealmia exaltata
    M. Sekiguchi; H. Shigemori; A. Ohsaki; J. Kobayashi
    Journal of Natural Products, 2001, Refereed, Not invited
  • Analysis of Major Components and Bisphenol a in Commercial Bis-GMA and Bis-GMA-based Resins Using High Performance Liquid Chromatography
    Yohji Imai; Mariko Watanabe; Ayumi Ohsaki
    Dental Materials Journal, 2000, Refereed, Not invited
  • Echinophyllins A and B, novel nitrogen-containing clerodane diterpenoids from Echinodorus macrophyllus
    Kobayashi; J.; Sekiguchi; M.; Shigemori; H.; Ohsaki; A.
    Tetrahedron Lett, Jan. 2000, Refereed, Not invited
    Corresponding
  • Chapecoderins A-C, new labdane-derived diterpenoids from Echinodorus macrophyllus
    Kobayashi; J.; Sekiguchi; M.; Shigemori; H.; Ohsaki; A.*
    J Nat Prod, Jan. 2000, Refereed, Not invited
    Corresponding
  • Echinophyllins C-F, new nitrogen-containing clerodane diterpenoids from Echinodorus macrophyllus
    Jun'ichi Kobayashi; Ayumi Ohsaki
    Journal of Natural Products, 2000, Refereed, Not invited
  • Analysis of Major Components Contained in Bis-GMA Monomer
    Ayumi Ohsaki; Yohji Imai
    Dental Materials Journal, 1999, Not refereed, Not invited
    Lead
  • An example of the co-occurrence of enantiomeric labdane-type diterpenes in the leaves of Mimosa hostilis
    Yoshiyasu Fukuyama; Ritsuko Yokoyama; Ayumi Ohsaki; Hironobu Takahashi; Hiroyuki Minami
    Chemical and Pharmaceutical Bulletin, 1999, Refereed, Not invited
  • Microanalysis of a selective potent anti-Helicobacter pylori compounds in a Brazilian medicinal plant, Myroxylon peruiferum
    Ohsaki; A.*; Takashima; J.; Chiba; N.; Kawamura; M.
    Bioorg Med Chem Lett, Jan. 1999, Refereed, Not invited
    Lead
  • Phylogenetic and Chemotaxonomic significance of diterpenes in some Portulaca species
    Ohsaki; A.; Shibata; K.; Kubota; T.; Tokoroyama; T.
    Biochem Syst Ecol, Jan. 1999, Refereed, Not invited
    Lead
  • 赤ワインでガン予防
    大崎愛弓
    化学と工業, Jan. 1998, Refereed, Not invited
    Lead
  • 抗ピロリ菌
    大崎愛弓
    化学と教育, Jan. 1998, Refereed, Not invited
    Lead
  • Portulene acetal, a novel minor constituent of Portulaca grandiflora with significance for the biosynthesis of portulal
    A. Ohsaki; Y. Asaka; T. Kubota; K. Shibata; T. Tokoroyama
    Journal of Natural Products, 1997, Refereed, Not invited
    Lead
  • Diterpenoid Constituents of Portulaca plants: Structure, Biosynthesis and Chemosystematics
    Ohsaki; A. Tokoroyama; T.
    Recent Research and Developments in Phytochemistry, Jan. 1997, Refereed, Not invited
    Lead
  • A DITERPENOID FROM PORTULACA-PILOSA
    A OHSAKI; Y KASETANI; Y ASAKA; K SHIBATA; T TOKOROYAMA; T KUBOTA
    Phytochemistry, Sep. 1995, Refereed, Not invited
    Lead
  • テルペノイド成分と植物系統進化
    大崎愛弓,野老山喬
    科学と工業, Jul. 1995, Refereed, Not invited
    Lead
  • The isolation and in vivo potent antitumor activity of clerodane diterpenoid from the oleoresin of the Brazilian medicinal plant, Copaifera langsdorfii Defson
    Ohsaki; A.; Lu; T. Y.; Ito; S.; Edatsugi; H.; Iwata; D.; Komoda; Y.
    Bioorg Med Chem Lett, Jan. 1994, Refereed, Not invited
    Lead
  • 5,5,7,3',4'-Tetrahydroxy-3-methoxy flavone, a potent anti-tumor promoter isolated from Gnafhaliu indicum
    Asaka; Y.; Ohsaki; A.; Kubota; T.; Matsukawa; Y.; Satomi; Y. Nishino; H.
    京都府立医科大学雑誌, Jan. 1992, Refereed, Not invited
  • CLERODANE DITERPENOIDS FROM THE ROOTS OF PORTULACA-PILOSA
    A OHSAKI; Y KASETANI; Y ASAKA; K SHIBATA; T TOKOROYAMA; T KUBOTA
    Phytochemistry, 1991, Refereed, Not invited
  • PERSEAPICROSIDE-A, HEXANORCUCURBITACIN-TYPE GLUCOPYRANOSIDE FROM PERSEA-MEXICANA
    A OHSAKI; T KUBOTA; Y ASAKA
    Phytochemistry, 1990, Refereed, Not invited
  • Studies on the constituents of Leucoseptrum stellipillum
    T. Isobe; Y. Noda; A. Ohsaki; S. Sakanaka; M. Kim; M. Taniguchi
    Yakugaku Zasshi, 1989, Refereed, Not invited
  • MINOR DITERPENOIDS FROM PORTULACA CV JEWEL
    A OHSAKI; N OHNO; K SHIBATA; T TOKOROYAMA; T KUBOTA; K HIROTSU; T HIGUCHI
    Pnytochemistry, 1988, Refereed, Not invited
    Lead
  • Structure of pilosanones A and B: Novel diterpenoids with a bicyclo[5.4.0]undecane skeleton from Portulaca pilosa L.
    Ayumi Ohsaki; Kozo Shibata; Takashi Tokoroyama; Takashi Kubota
    Journal of the Chemical Society, Chemical Communications, 1987, Refereed, Not invited
    Lead
  • Efficient synthesis of benzofuran derivatives via intermolecular friedel-crafts acilation of furans
    Kotsuki; H.; Yamaguchi; Y.; Ohsaki; A.; Ochi; M.
    高知大学紀要, Jan. 1987, Not refereed, Invited
  • NOVEL DITERPENES WITH BICYCLO[5.4.0]UNDECANE SKELETON FROM PORTULACA-GRANDIFLORA HOOK, POSSIBLE LINKING INTERMEDIATES IN THE BIOSYNTHESIS OF PORTULAL
    A OHSAKI; K SHIBATA; T TOKOROYAMA; T KUBOTA; H NAOKI
    CHEMISTRY LETTERS, Sep. 1986, Refereed, Not invited
    Lead
  • CLERODANE DITERPENOIDS FROM PORTULACA-CV JEWEL
    A OHSAKI; N OHNO; K SHIBATA; T TOKOROYAMA; T KUBOTA
    PHYTOCHEMISTRY, 1986, Refereed, Not invited
    Lead
  • DITERPENOID CONGENERS OF PORTULAL IN PORTULACA-GRANDIFLORA HOOK
    A OHSAKI; K MATSUMOTO; K SHIBATA; T KUBOTA; T TOKOROYAMA
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, Refereed, Not invited
    Lead
  • PORTULIDE, A CLERODANE DITERPENOID FROM PORTULACA-GRANDIFLORA HOOK
    A OHSAKI; K MATSUMOTO; K SHIBATA; T TOKOROYAMA; MIURA, I
    CHEMISTRY LETTERS, 1984, Refereed, Not invited
    Lead
  • INTRAMOLECULAR DIELS-ALDER REACTIONS OF VINYLFURAN DERIVATIVES - A NOVEL-APPROACH TO BENZOFURANS
    H KOTSUKI; A KAWAMURA; M OCHI; T TOKOROYAMA
    CHEMISTRY LETTERS, 1981, Refereed, Not invited

MISC

  • キョウチクトウ科植物Aspidosperma subincanum由来の新規インドールアルカロイドSubincanadineA-Fの構造
    石山玄明; 関口光広; しま本沙矢香; 繁森英幸; 大崎愛弓; 小林淳一
    日本薬学会年会要旨集, 2003
  • ブラジル産薬用植物Echinodorus macrophyllusより単離したジテルペノイドの構造
    関口光広; 島本沙矢香; 繁森英幸; 小林淳一; 大崎愛弓
    天然薬物の開発と応用シンポジウム講演要旨集, 2001
  • ブラジル産薬用植物Echinodorus macrophyllusより単離したEchinophyllin AおよびBの構造
    繁森英幸; 関口光広; 小林淳一; 大崎愛弓
    日本生薬学会年会講演要旨集, 2000
  • Structures of chapecoderins A~C, isolated from Brazilian medicinal plant, Echinodorus macrophyllus.
    大崎愛弓; 関口光弘; 繁森英幸; 小林淳一
    日本化学会講演予稿集, 2000

Books and other publications

  • 大学基礎・専門課程の化学実験マニュアル,第3版
    Contributor, 日本大学文理学部化学科編
    Apr. 2019, Refereed
    9784320044951
  • 知のスクランブル-文理的思考の挑戦 (分担執筆)植物を化学する
    日本大学文理学部編, Joint work, 日本大学文理学部編
    ちくま新書, Feb. 2017, Not refereed

Lectures, oral presentations, etc.

  • New diterpenoids and activities from Salvia species in China
    Hiroshi Kawabe; Yukiko Nobe; Yasuko Okamoto; Miwa Kubo; Kenichi Harada; Yukiyasu Fukuyama; Hiroshi Hirota; Xun Gong; Ayumi Ohsaki
    The international chemical congress of Pacific Basin societies 2025 (Pacifichem 2025), Not invited
  • Diterpene diversity of Portulaca grandiflora
    Ayumi Ohsaki; Minori Nonaka; Yasuko Okamoto
    The international chemical congress of Pacific Basin societies 2025 (Pacifichem 2025), Dec. 2025, Not invited
  • 2(3H)-Dihidrofuran from Pleosporales sp. NUH 322 as anti-ALS drug candidate
    Kuniko Kusama-Eguchi; Yasuhiro Kosuge; Dai Hirose; Motofumi Miura; Keiichi Mastuzaki; Ayumi Ohsak
    The international chemical congress of Pacific Basin societies 2025 (Pacifichem 2025), Dec. 2025, Not invited
  • A novel valerolactones isolated from Pleoseporales sp. NUH322 prolonging lifespan of SOD1-93A mice as a candidate for ALS drug
    Kuniko Kusama-Eguchi; Yuki Tokui; Yuta Yanai; Yasuhiro Kosuge; Motofumi Miura; Megumi Furukawa; Mitsuko Makino; Emika Ohkoshi; Keiischi Matsuzaki; Ayumi Ohsaki
    19th World Congress of Basic & Clinical Phamacology 2023 (WCP2023), Dec. 2023
  • New diterpenoids and activities from Salvia species in Hengduan Mountains
    Ayumi Ohsaki; Mariko Funasaki; Hiroshi Hirota; Yasuko Okamoto; Yoshinori Saito; Gong Xun
    Pacifichem 2021, Not invited
  • A novel valerolactone as an ALS remedy canditate from a Filamentous Fungi
    Yuki Tokui; Yuta Yanai; Dai Hirose; Yasuhiro Kosuge; Keisuke Matsuzaki; Kuniko Kusama-Eguchi; Ayumi Ohsaki
    The international chemical congress of Pacific Basin societies 2025 (Pacifichem 2021), Dec. 2021, Not invited
  • Isolation and functional analysis of natural fluorescent compounds from Orix japonica.
    Masahiko Hoshino; Shingo Hashimoto; Yusuke Kobayashi; Mariko Funasaki; Noriko Yasuhara; Noriko Shibasaki; Hiroyuki Kagechika; Tomoya Hirano; Ayumi Ohsaki
    Pacifichem 2021, Honolulu, USA, Not invited
  • Search for new compounds from Portulaca pilosa. 30th International Symposium on the Chemistry of Natural Products
    Nonaka, M.; Hara, E.; Seike, A.; Okamoto, Y.; Kubo, M.; Funasaki, M.; Fukuyama, Y.; Matsuzaki, K.; Hirota, H.; Ohsaki, A.
    30th International Symposium on the Chemistry of Natural Products, Royal Olympic Hotel, Athens, Greece,, Not invited
  • Phytochemical diversity of Salvia species inHengduan Mountains.
    Ohsaki, A.; Kawabe, H.; Kuwada, K.; Funasaki, M.; Hiroshi, H.; Tsukada, H.; Komiyama, T.; Kagechika, H.; Okamoto, Y.; Tori, M.; Saito, Y.; Gong, X.
    0th International Symposium on the Chemistry of Natural Products,Royal Olympic Hotel, Athens, Greece,, Not invited
  • Development and application of novel polarity-sensitive fluorophore based on fluorescent natural compounds
    Yokoo, H.; Ohsaki, A.; Hirano, T.; Kagechika, H.
    The 3rd. synposium on Biomedical Engineering, Hiroshima Univ., Hiroshima, Japan, Not invited
  • Development of novel environment-devendent fluorophore derived from fluorescent natural compounds
    Yokoo, H.; Ohsaki, A.; Hirano, T.; Kagechika, H.
    Godon Research Conference, State-of-the -Art Bioanalytical Sensing Approached for Healthcare and Therapeutics, Forensics, and Visualization of Living Systems, Newport USA, Invited
  • Chemical constituents of Salvia species collected in Sichuan Province of China.
    Kuwada, K.; Kawabe, H.; Saito, Y.; Okamoto, Y.; Tori, M.; Gong, X.; l; Hirota, H.; Ohsaki., A.
    ISNPF2016(International Symposium on Natural Products for the Future 2016 Tokushima), Not invited
  • New Erythrina Alkaloids from Erythrina velutina.
    Todoroki, K.; Hirota, H.; Ohsaki, A.
    ISNPF2016(International Symposium on Natural Products for the Future 2016 Tokushima),, Not invited
  • Phytochemicals of Salvia species and Lugularia species
    Ohsaki, A.; Kuwada, K.; Kawabe, H.; Watanabe, D.; Kato, T.; Funasaki, M.; Hirota, H.
    ISNPF2016(International Symposium on Natural Products for the Future 2016 Tokushima), Not invited
  • Synthetic Study on fluorescent alakaloid amarastelline A using termolecular condensation reaction.
    Harada, K.; Yamabe, H.; Kubo, M.; Ohsaki, A.; Fukukyama, A.
    ISNPF2016 (International Symposium on Natural Products for the Future 2016 Tokushima), Invited
  • A. Synthetic Study on fluorescent alakaloid amarastelline A using termolecular condensation reaction.
    Harada, K.; Yamabe, H.; Kubo, M.; Ohsaki, A.; Fukukyama
    The 3rd. synposium on Biomedical Engineering, Hiroshima Univ., Hiroshima, Japan, Not invited
  • Development of Novel Fluorescent Sensors Based on Fluorescent Natural Compounds,
    Yokoo, H.; Hirano, T.; Ohsaki, A.; Kagechika, H.
    252nd, ACS National Meeting in Philadelphia, Not invited
  • Furanocassane diterpenoids from Bowdichia virgilioides,
    Kasahara T.; Natsume S.; Harada K.; Kubo M.; Fukuyama Y.; Endo Y.; Ohsaki A.
    Inaugural Symposium of the Phytochemical Society of Asia 2015, Tokushima, Japan, Not invited
  • Fluorescent compounds from Quassia amara
    Hinata N.; Hirano T.; Kagechica H.; Ohsaki A.
    Fluorescent compounds from Quassia amara,Inaugural Symposium of the Phytochemical Society of Asia 2015, Tokushima, Japan, Not invited
  • Search for bioactive constituents from subtropical medicinal plants, Securinega suffruticosa var. amamiensis
    Kodama Y.; Shimada M.; Kubo M.; Fukuyama Y.; Ohsaki A.
    Inaugural Symposium of the Phytochemical Society of Asia 2015, Not invited
  • New abietane diterpenoids from Salvia grandifolia,
    Kawabe H.; Komiyama T.; Saito Y.; Tori M.; Kuroda C.; Gong X.; Ohsaki A.
    Inaugural Symposium of the Phytochemical Society of Asia 2015, Tokushima, Japan,, Not invited
  • Furanocassane diterpenoids from Bowdichiavirgilioides,
    Ohsaki A.; Endo Y.; Kasahara T.; Harada K.; Kubo M.; Fukuyama Y.
    American Society of Pharmacognosy, 2014 Annual Meeting,Oxford, MS, USA, Not invited
  • Anti-Listeosis compounds from resemary
    Ohsaki A.; Ozawa M.; Taniguchi K.; Asai H.; Kido H.
    Value-added food products from fruit and vegetables, Pacifichem 2010, Honolulu, USA, Invited
  • A novel fluorescent compounds from a tropical medicinal plants, Quassia amara
    Taniguchi K.; Ozawa M.; Maruyama T.; Kishida A.; Murata S.; Ohsaki A.
    Recent advances in natural products as anticancer agents, Pacifichem2010, Honolulu, USA, Not invited
  • Structured and biological activities of constituents from Erythrina velutina
    Ozawa M.; Etoh T.; Hayashi M.; Honda K.; Komiyama K.; Kishida K.; Ohsaki A.
    Recent advances in natural products as anticancer agents, Pacifichem2010, Honolulu, USA,, Not invited
  • Search for bioactive compounds from medicinal plants of Bangradesh regarding anti-cancer properties
    Ohsaki A.; Ozawa M.; Taniguchi K.; Kishida A.; Ahmed F.; Samir KS; Ishibashi M.
    Recent advances in natural products as anticancer agents, Pacifichem2010, Honolulu, USA, Not invited
  • Erythrinan alkaloids from Erythrina crista-galli with inhibitory activity on LPS-induced nitric oxide
    Kawamata S.; Ozawa M.; Etoh T.; Hayashi M.; Komiyama K.; Kishida A.; Ohsaki A.; Kuroda C.
    Recent advances in natural products as anticancer agents, Pacifichem2010, Honolulu, US, Not invited
  • Search for cytotoxic compounds from Tilia kiusiana,
    Shimada M.; Ozawa M.; Iwamoto K.; Kishida, A.; Ohsaki A.
    Recent advances in natural products as anticancer agents, Pacifichem2010, Honolulu, USA, Not invited

Affiliated academic society

  • Jan. 2008 - Present
    日本ケミカルバイオロジー学会
  • Jan. 2000 - Present
    アメリカ生薬学会
  • Jan. 2000 - Present
    日本生薬学会
  • Apr. 1987 - Present
    日本薬学会
  • Jan. 1984 - Present
    アメリカ化学会
  • Apr. 1981 - Present
    日本化学会

Research Themes

  • 新規天然蛍光イメージリング剤の創出と生細胞内動的解析
    Apr. 2020 - Mar. 2024
  • ひらめきときめきサイエンスようこそ大学の研究室へKAKENHI 植物に含まれる蛍光成分で細胞を光らせてみよう
    Apr. 2022 - Mar. 2023
  • ひらめきときめきサイエンスようこそ大学の研究室へKAKENHI ,光る化合物を取り出してみよう
    Apr. 2020 - Mar. 2021
  • 新規天然蛍光分子の探索と生細胞イメージリング剤の創出
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2016 - Mar. 2021
    大崎愛弓
  • ひらめきときめきサイエンスようこそ大学の研究室へKAKENHI 光る化合物をのぞいてみよう
    Apr. 2019 - Mar. 2020
  • Field study of medicinal natural resources in Bangladesh
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2014 - Mar. 2018
    Ishibashi Masami; ARAIA MIDORI; TOUME KAZUFUMI; ISHIKAWA NAOKI
  • The inventory of rare plants and these evaluation of both usefulness and safety by the utilization of GIS as geographic information system technology
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Oct. 2013 - Mar. 2018
    WATANABE TAKASHI; TANAKA NOBUYUKI; KIKUCHI YUTAKA; DEVKOTA HARI; OSAKI AYUMI; YAMAJI SEIICHI; Tyo San Oo; BISTA GYATSO; BISTA TENJIN; Pitisopa Fred; Pattson Tofu
  • Evaluation and Estimation of Important Plant Resource for new Agroforestry
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2014 - 31 Mar. 2017
    TAKAGI Masataka; OOSAKI Ayumi; INAGAKI Noritoshi; MURAI Ryosuke; NAGANO Masao
  • Chemical and genetic study of plant evolution and speciation in the Hengduan Mountains of China
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2013 - 31 Mar. 2017
    KURODA Chiaki; GONG Xun; HAO Xiaojiang
  • 薬用植物由来新規生細胞蛍光イメージリング剤の探索と創製
    Apr. 2012 - Mar. 2016
  • Field Study on natural medicinal resources in Bangladesh
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2011 - 31 Mar. 2015
    ISHIBASHI Masami; OHSAKI Ayumi; ARAI A. MIDORI; TOUME Kazufumi
  • Study on Speciation Mechanisms of Plants in the Hengduan Mountains of China -An Approach Examining Their Chemical and Genetic Diversities-
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2009 - 2012
    KURODA Chiaki; HANAI Ryo; TORI Motoo; SAITO Yoshinori; NAGANO Hajime; OHSAKI Ayumi; HIROTA Hiroshi; KAWAHARA Takayuki
  • Field Study on natural medicinal resources in Bangladesh
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2008 - 2010
    ISHIBASHI Masami; ARAI Midori; OHSAKI Ayumi; OHTSUKI Takashi; TOUME Kazufumi
  • Chemical and genetic diversity of Ligularia species of Yunnan province of China
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2004 - 2006
    KURODA Chiaki; HANAI Ryo; SEKINE Yasuhiko; TORI Motoo; NAGANO Hajime; OHSAKI Ayumi
  • 高選択的抗ヘリコバクターピロリ活性物質の分子設計と作用機序
    日本学術振興会, 科学研究費助成事業, Apr. 2000 - Mar. 2001
    大崎 愛弓
  • 新しい作用機序をもつ抗マラリア物質の探索
    日本学術振興会, 科学研究費助成事業, 2000 - 2001
    小林 淳一; 大崎 愛弓; 繁森 英幸
  • 高選択的抗ヘリコバクターピロリ活性物質の分子設計と作用機序
    日本学術振興会, 科学研究費助成事業, 2000 - 2000
    大崎 愛弓
  • Collaboration on DNA sequence-specific recognition by small molecules
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1998 - 2000
    SUGIYAMA Hiroshi; ITO Shigeru; SUGIMOTO Akiko
  • スベリヒユ科植物の成分研究
    日本学術振興会, 科学研究費助成事業, Apr. 1985 - Mar. 1986
    大崎 愛弓