オルガネラの形成・成熟

ライブイメージング

differentiation

exocytosis

secretory granule

crinophagy

salivary gland

Life sciences, Oral medicine, Functional Basic Odontology

Life sciences, Physiology

Life sciences, Cell biology, Cell Biology

Apr. 2011 - Present
日本大学松戸歯学部教授

1993
The University of Tokyo, Graduate School, Division of Science, 生物化学

1987
The University of Tokyo, Faculty of Science, 生物化学

Sep. 2020 - Present
教育委員, 歯科基礎医学会

Jan. 2017 - Present
評議員, 国際歯科研究学会日本支部

Dec. 2013 - Present
理事, 日本唾液腺学会

Aug. 2007 - Present
評議員, 歯科基礎医学会

Oct. 2017 - Sep. 2023
代議員, 日本生化学会

Aug. 2016 - Sep. 2020
倫理委員, 歯科基礎医学会

Apr. 2009 - Mar. 2013
「生化学」誌企画協力委員, 日本生化学会

第9回歯科基礎医学会ライオン学術賞受賞

Gordon Research Conference on Salivary Gland and Exocrine Secretion Award for Poster Presentation

第9回歯科基礎医学会賞

Effects of Aging on the Relationship between Ionic Components in Saliva and Salt Taste Preference
Akiko Hamano; Megumi Yokoyama; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
International Journal of Oral-Medical Sciences, Mar. 2025, Refereed, Not invited
Corresponding

Association between the Cation Concentrations in Saliva and the Sensitivity and Preference of Salty Taste
Akiko Hamano; Megumi Yokoyama; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
International Journal of Oral-Medical Sciences, Feb. 2025, Refereed
Corresponding

Decline in stimulus responsiveness of secretory granules in salivary glands with age
Miyuki Toda; Megumi Yokoyama; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
Journal of Oral Biosciences, Nov. 2024, Refereed, Not invited
Corresponding

Association between central sensitivity syndrome and psychophysical factors in patients with masticatory myofascial pain
Keita Takizawa; Kana Ozasa; Zhimin Yan; Suzuro Hitomi; Junko Fujita-Yoshigaki; Masakazu Okubo; Kenji Yoshikawa; Masamichi Shinoda; Eli Eliav; Noboru Noma
Journal of Oral Science, Jul. 2024, Refereed, Not invited

The secretory ability of newly formed secretory granules is regulated by pro-cathepsin B and amylase in parotid glands
Osamu Katsumata-Kato; Megumi Yokoyama; Junko Fujita-Yoshigaki
Biochemical and Biophysical Research Communications, Jul. 2023, Refereed, Not invited

Acinar Cell Proliferation Promoted by BMP2 in Injured Mouse Parotid Gland: BMP2 Promotes Cell Proliferation in Parotid Gland
Megumi Yokoyama; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
International Journal of Dentistry, Mar. 2023, Refereed

BMP-1-induced GBA1 nuclear accumulation provokes CCN2 mRNA expression via importin-β-mediated nucleocytoplasmic pathway
Koichiro Muromachi; Rei Nakano; Junko Fujita-Yoshigaki; Hiroshi Sugiya; Nobuyuki Tani-Ishii
Journal of Cell Communication and Signaling, Mar. 2023, Refereed

Switching of cargo sorting from the constitutive to regulated secretory pathway by the addition of cystatin D sequence in salivary acinar cells
Fujita-Yoshigaki J; Yokoyama M; Katsumata-Kato O
Am J Physiol Gastrointest Liver Physiol, Jun. 2020, Refereed, Not invited
Lead

Hematogenous apoptotic mechanism in salivary glands in chronic periodontitis.
Shikayama T; Fujita-Yoshigaki J; Sago-Ito M; Nakamura-Kiyama M; Naniwa M; Hitomi S; Ujihara I; Kataoka S; Yada N; Ariyoshi W; Usui M; Nakashima K; Ono K
Arch Oral Biol, Jun. 2020, Refereed, Not invited

Expression of stem cell marker nestin in non-injured side of the salivary gland associated with unilateral salivary gland injury
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
日大口腔科学, Mar. 2020, Refereed, Not invited
Last

Suppression of parotid acinar cell dysfunction by the free radical scavenger 3-methyl-1-phenyl-2-pyrazolin-5-one
Sakurai H; Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
J Oral Sci, Aug. 2019, Refereed, Not invited
Corresponding

Difference in calcium mobilization between two strains of mice that have different abilities to secrete saliva
Sakurai H; Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
Int J Oral-Med Sci, Jun. 2019, Refereed, Not invited
Corresponding

Change in expression patterns of micro RNAs in the primary culture of parotid acinar cells
Ogawa H; Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
Int J Oral-Med Sci, Mar. 2019, Refereed, Not invited
Corresponding

Expression of a neural stem/progenitor cell marker nestin in salivary glands.
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
MOJ Anatomy & Physiology, Sep. 2017, Refereed, Not invited

Determinants for selective transport of exogenously expressed cargo proteins into regulated and constitutive secretory pathways
Junko Fujita-Yoshigaki; Megumi Yokoyama; Osamu Katsumata-Kato
Journal of Oral Biosciences, May 2017, Refereed, Invited
Lead

Maintenance of claudin-3 expression and the barrier functions of intercellular junctions in parotid acinar cells via the inhibition of Src signaling.
Yokoyama M; Narita T; Sakurai H; Katsumata-Kato O; Sugiya H; Fujita-Yoshigaki J
Arch Oral Biol, May 2017, Refereed, Not invited
Corresponding

耳下腺腺房細胞の初代培養細胞における遺伝子発現変化の網羅的解析
横山愛,加藤治,吉垣純子
日大口腔科学, Mar. 2017, Refereed, Not invited
Corresponding

Syntaxin 6 is involved in the maintenance of secretory granules in parotid acinar cells.
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
Int J Oral-Med Sic, Mar. 2017, Refereed, Not invited
Corresponding

Expression of the stem cell marker nestin in response to tissue injuries of parotid acinar cells
Yokoyama M; Ogawa H; Katsumata-Kato O; Fujita-Yoshigaki J
Int J Oral-Med Sci, Mar. 2017, Refereed, Not invited
Corresponding

Syntaxin 6 is Involved in the Maintenance of Secretory Granules in Parotid Acinar Cells
Megumi Yokoyama; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
International Journal of Oral-Medical Sciences, 2017

Expression of the Stem Cell Marker Nestin in Response to Tissue Injuries of Parotid Acinar Cells
Megumi Yokoyama; Hiroaki Ogawa; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
International Journal of Oral-Medical Sciences, 2017

唾液腺初代培養細胞の可能性を探る
吉垣純子
日本唾液腺学会誌, Nov. 2015, Not refereed, Not invited
Lead

Secretory proteins without a transport signal are retained in secretory granules during maturation in rat parotid acinar cells
Osamu Katsumata-Kato; Megumi Yokoyama; Miwako Matsuki-Fukushima; Takanori Narita; Hiroshi Sugiya; Junko Fujita-Yoshigaki
ARCHIVES OF ORAL BIOLOGY, Apr. 2015, Refereed, Not invited

MC3T3-E1 cell assay on collagen or fibronectin immobilized poly (lactic acid-e-caprolactone) film.
Fuse M; Hayakawa T; Hashizume-Takizawa T; Takeuchi R; Kurita-Ochiai T; Fujita-Yoshigaki J; Fukumoto M
J. Hard Tissue Biol., 2015, Refereed, Not invited

The sorting mechanism underlying the separation of salivary proteins into secretory granules in parotid glands
Junko Fujita-Yoshigaki; Miwako Matsuki-Fukushima; Megumi Yokoyama; Osamu Katsumata-Kato
Journal of Oral Biosciences, 2014, Refereed, Invited

Sorting of a HaloTag protein that has only a signal peptide sequence into exocrine secretory granules without protein aggregation
Junko Fujita-Yoshigaki; Miwako Matsuki-Fukushima; Megumi Yokoyama; Osamu Katsumata-Kato
American Journal of Physiology - Gastrointestinal and Liver Physiology, Nov. 2013, Refereed, Not invited

Effects of [6]-gingerol on dedifferentiation of salivary acinar cells.
Yokoyama M; Haruki M; Matsuki-Fukushima M; Nagai-Fuse M; Narita T; Okabayashi K; Sugiya H; Katsumata-Kato O; Fujita-Yoshigaki J
Int J Oral Med Sci, Apr. 2013, Refereed, Not invited
Corresponding

Involvement of AQP6 in the mercury-sensitive osmotic lysis of rat parotid secretory granules
Miwako Matsuki-Fukushima; Junko Fujita-Yoshigaki; Masataka Murakami; Osamu Katsumata-Kato; Megumi Yokoyama; Hiroshi Sugiya
Journal of Membrane Biology, Mar. 2013, Refereed, Not invited

唾液腺導管結紮時におけるcytokeratin 5の発現
横山愛,加藤治,福島美和子,吉垣純子
日大口腔科学, Apr. 2012, Refereed, Not invited

Role of aquaporin-6 in rat parotid secretory granules.
Matsuki-Fukushima M; Fujita-Yoshigaki J; Murakami M; Katsumata-Kato O; Sugiya H
Journal of Oral Biosciences, Dec. 2011, Refereed, Not invited

The actin-specific reagent jasplakinolide induces apoptosis in primary rat parotid acinar cells.
Matsuki-Fukushima M; Hashimoto S; Murakami M; Ogata Y; Fujita-Yoshigaki J; Narita T; Sugiya H
Arch Oral Biol, Nov. 2011, Refereed, Not invited

Analysis of changes in the expression pattern of claudins using salivary acinar cells in primary culture.
Fujita-Yoshigaki J
Methods Mol Biol, Jul. 2011, Refereed, Not invited
Lead

Role of Aquaporin-6 in Rat Parotid Secretory Granules
Miwako Matsuki-Fukushima; Junko Fujita-Yoshigaki; Masataka Murakami; Osamu Katsumata-Kato; Hiroshi Sugiya
Journal of Oral Biosciences, 2011

Maintenance of paracellular barrier function by insulin-like growth factor-I in submandibular gland cells
Retsu Mitsui; Junko Fujita-Yoshigaki; Takanori Narita; Miwako Matsuki-Fukushima; Keitaro Satoh; Bing Qi; Ming-Yu Guo; Osamu Katsumata-Kato; Hiroshi Sugiya
ARCHIVES OF ORAL BIOLOGY, Dec. 2010, Refereed, Not invited

Thiol-oxidation reduces the release of amylase induced by β-adrenergic receptor activation in rat parotid acinar cells.
Guo MY; Satoh K; Qi B; Narita T; Katsumata-Kato O; Matsuki-Fukushima M; Fujita-Yoshigaki J; Sugiya H
Biomed Res, Nov. 2010, Refereed, Not invited

Characteristics of neurokinin A-induced salivary fluid secretion in perfused rat submandibular gland
Bing Qi; Takanori Narita; Keitaro Satoh; Ming-Yu Guo; Osamu Katsumata-Kato; Masataka Murakami; Junko Fujita-Yoshigaki; Hiroshi Sugiya
ARCHIVES OF ORAL BIOLOGY, Oct. 2010, Refereed, Not invited

Plasticity in differentiation of salivary glands—The signaling pathway that induces dedifferentiation of parotid acinar cells—
Fujita-yoshigaki J
Journal of Oral Biosciences, May 2010, Refereed, Not invited
Lead

RP–HPLC–ESI–MS characterization of novel peptide fragments related to rat parotid secretory protein in parasympathetic induced saliva.
Ekström J; Murakami M; Inzitari R; Khosravani N; Fanali C; Cabras T; Fujita-Yoshigaki J; Sugiya H; Messana I; Castagnola M
J Sep Sci, Jul. 2009, Refereed, Not invited

Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells
Keitaro Satoh; Miwako Matsuki-Fukushima; Bing Qi; Ming-Yu Guo; Takanori Narita; Junko Fujita-Yoshigaki; Hiroshi Sugiya
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Jun. 2009, Refereed, Not invited

Separation of immature granules containing color dye from the rat parotid gland
Katsumata-Kato O; Fujita-Yoshigaki J; Narita T; Sugiya H
J Med Invest, Jan. 2009, Refereed, Not invited
Lead

Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells
Sugiya H; Satoh K; Matsuki-Fukushima M; Qi B; Guo MY; Fujita-Yoshigaki J
J Med Invest, Jan. 2009, Refereed, Not invited

The thiol-oxidizing agent diamide reduces isoproterenol-stimulated amylase release in rat parotid acinar cells
Guo MY; Narita T; Qi B; Satoh K; Katsumata-Kato O; Matsuki-Fukushima M; Fujita-Yoshigaki J; Sugiya H
J Med Invest, Jan. 2009, Refereed, Not invited

Parotid acinar cells transiently change to duct-like cells during epithelial-mesenchymal transition
Fujita-Yoshigaki J; Qi B; Narita T; Sugiya H
J Med Invest, Jan. 2009, Refereed, Not invited
Lead

Enhancement of barrier function by overexpression of claudin-4 in tight junctions of submandibular gland cells.
Michikawa T; Fujita-Yoshigaki J; Sugiya H
Cell Tissue Res, Oct. 2008, Refereed, Not invited
Corresponding

耳下腺細胞開口分泌におけるPKCδによるMARCKSリン酸化
佐藤 慶太郎; 郭 明宇; 祁 兵; 成田 貴則; 勝俣 治; 吉垣 純子; 杉谷 博士
Journal of Oral Biosciences, Sep. 2008

灌流ラット顎下腺におけるニューロキニンAによる傍細胞経路を介した唾液分泌の誘導(Neurokinin A induces salivary secretion via paracellular pathway in the perfused rat submandibulr gland)
祁 兵; 成田 貴則; 三井 烈; 佐藤 慶太郎; 郭 明宇; 勝俣 治; 吉垣 純子; 村上 政隆; 杉谷 博士
Journal of Oral Biosciences, Sep. 2008

耳下腺アミラーゼ分泌シグナルにおけるMARCKSの局在変化
佐藤 慶太郎; 中尾 寿美; 成田 貴則; 勝俣 治; 吉垣 純子; 浅野 正岳; 茂呂 周; 小菅 康弘; 伊藤 芳久; 杉谷 博士
日大口腔科学, Aug. 2008

Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells.
Fujita-Yoshigaki; J.; Matsuki-Fukushima; M.; Sugiya; H.
Am J Physiol Cell Physiol, Feb. 2008, Refereed, Not invited
Lead

Presence and localization of aquaporin-6 in rat parotid acinar cells.
Matsuki-Fukushima; M.; Hashimoto; S.; Shimono; M.; Satoh; K.; Fujita-Yoshigaki; J.; Sugiya; H.
Cell and Tissue Research, 2008, Refereed, Not invited

耳下腺腺房細胞初代培養細胞における脱分化シグナル
吉垣 純子; 福島 美和子; 三井 烈; 佐藤 慶太郎; 杉谷 博士
Journal of Oral Biosciences, Aug. 2007

耳下腺腺房細胞アミラーゼ分泌におけるMARCKSの役割
佐藤 慶太郎; 福島 美和子; 三井 烈; 吉垣 純子; 杉谷 博士
Journal of Oral Biosciences, Aug. 2007

IGF-Iがラット顎下腺由来培養細胞に及ぼす影響
三井 烈; 吉垣 純子; 福島 美和子; 佐藤 慶太郎; 杉谷 博士
Journal of Oral Biosciences, Aug. 2007

耳下腺分泌顆粒におけるアクアポリンの浸透圧調節への寄与
福島 美和子; 橋本 貞充; 村上 政隆; 佐藤 慶太郎; 三井 烈; 吉垣 純子; 杉谷 博士
Journal of Oral Biosciences, Aug. 2007, Refereed, Not invited

Syntaxin6 separates from GM1a-rich membrane microdomain during granule maturation.
Katsumata O; Fujita-Yoshigaki J; Hara-Yokoyama M; Yanagishita M; Furuyama S; Sugiya H
Biochem Biophys Res Commun, Apr. 2007, Refereed, Not invited

Differences in claudin synthesis in primary cultures of rat salivary gland acinar cells are correlated with the specific three-dimensional organization of the cells.
Qi B; Fujita-Yoshigaki J; Michikawa H; Satoh K; Katsumata O; Sugiya H
Cell Tissue Res, Mar. 2007, Refereed, Not invited
Corresponding

唾液腺細胞における細胞間結合の制御
三井 烈; 吉垣 純子; 松木 美和子; 佐藤 慶太郎; 杉谷 博士
日本唾液腺学会誌, Nov. 2006

耳下腺腺房細胞の初代培養細胞におけるclaudin-4の発現制御
吉垣 純子; 三井 烈; 佐藤 慶太郎; 松木 美和子; 杉谷 博士
Journal of Oral Biosciences, Sep. 2006

ラット耳下腺腺房細胞におけるMARCKSの発現とリン酸化
佐藤 慶太郎; 松木 美和子; 三井 烈; 吉垣 純子; 杉谷 博士
Journal of Oral Biosciences, Sep. 2006

Difference in Distribution of Membrane Proteins between Low- And High-density Secretory Granules in Parotid Acinar Cells.
Fujita-Yoshigaki J; Katsumata O; Matsuki M; Yoshigaki T; Furuyama S; Sugiya H
Biochem. Biophys. Res. Comm., 2006, Refereed, Not invited
Lead

Phosphodiesterases 1 and 2 regulate cellular cGMP level in rabbit submandibular gland cells.
Michikawa; H.; Sugiya; H.; Yoshigaki; T.; Fujita-Yoshigaki; J.; and Furuyama; S.
Int J Biochem Cell Biol, 2005, Refereed, Not invited

Involvement of aquaporin-5 water channel in osmoregulation in parotid secretory granules.
Matsuki; M.; Hashimoto; S.; Shimono; M.; Murakami; M.; Fujita-Yoshigaki; J.; Furuyama; S.; and Sugiya; H.
J. Membrane Biol., 2005, Refereed, Not invited

A Primary Culture of Parotid Acinar Cells Retaining Capacity for Agonists-induced Amylase Secretion and Generation of New Secretory Granules.
Fujita-Yoshigaki; J.; Tagashira; A.; Yoshigaki; T.; Furuyama; S.; and Sugiya; H.
Cell Tissue Res., 2005, Refereed, Not invited
Lead

耳下腺腺房細胞におけるVAMP3タンパク質の発現と局在
吉垣純子,通川広美,古山俊介
日大口腔科学, 2005, Refereed, Not invited
Lead

Involvement of phospholipase D in the CAMP-regulated exocytosis of rat parotid acinar cell.
Dohke Y; Fujita-Yoshigaki J; Sugiya H; Furuyama S; Hara-Yokoyama M
Biochem. Biophys. Res. Comm., 2002, Not refereed, Not invited

Cyclic AMP has distinct effects from Ca2+ in evoking priming and fusion/exocytosis in parotid amylase secretion.
Yoshimura; K.; Fujita-Yoshigaki; J.; Murakami; M.; and Segawa; A.
Pflugers Arch, 2002, Refereed, Not invited

Ca²⁺-regulated nitiric oxide generation in rabbit paraotid acine cells.
H Sugiya; Y Mitsui; H Michikawa; J Fujita-Yoshigaki; M Hara-Yokoyama; S Hashimoto; S Furuyama
Cell Calcium, 2001, Not refereed, Not invited

Association of FcgRII with low-density dentergent-resistant membranes is important for cross-linking-dependent initiation of the tyrosine phosphprylation pathway and superoxide generation.
Katsumata O; Hara-Yokoyama M; Sautes-Fridman C; Nagatsuka Y; Katada T; Hirabayashi Y; Shimizu K; Fujita-Yoshigaki J; Sugiya H; Furuyama S
J. Immunol., 2001, Not refereed, Not invited

Complex Gangliosides as Cell Surface Inhibitors for the Ecto-NAD⁺ Glycohydrolase of CD38.
Miki Hara-Yokoyama; Yasuko Nagatsuka; Osamu Katsumata; Fumitoshi Irie; Kenji Kontani; Shin-ichi Hoshino; Toshiaki Katada; Yasushi Ono; Junko Fujita-Yoshigaki; Hiroshi Sugiya; Shunsuke Furuyama; Yoshio Hirabayashi
Biochemistry, 2000, Not refereed, Not invited

Simulation of regulated exocytosis of amylase from salivary parotid acinar cells by a consecutive reaction model comprising two sequential first-order reactions.
Fujita-Yoshigaki J
Journal of Theoretical Biology, 2000, Not refereed, Not invited
Lead

Presence of a complex containing vesicle-associated membrane protein2 in rat parotid acinar cells and its disassembly upon activation of cAMP-dependent protein kinase(共著)
Fujita-Yoshigaki J; Dohke Y; Hara-Yokoyama M; Furuyama S; Sugiya H
Journal of Biological Chemistry, 1999, Not refereed, Not invited
Lead

cGMP production is coupled to Ca²⁺-dependent nitric oxide generation in rabbit parotid acinar cells. (共著)
H Michikawa; Y Mitsui; J Fujita-Yoshigaki; M Hara-Yokoyama; S Furuyama; H Sugiya
Cell Calcium, 1998, Not refereed, Not invited

SNARE proteins essential for cyclic AMP-regulated exocytosis in salivary glands. (共著)
J Fujita-Yoshigaki; Y Dohke; M Hara-Yokoyama; S Furuyama; H Sugiya
European Journal of Morphology, 1998, Not refereed, Not invited

ADP-ribosylation factors in rat parotid acinar cells. (共著)
D Looms; B Nauntofte; S Dissing
European Journal of Morphology, 1998, Not refereed, Not invited

Ca²⁺-nitric oxide-cGMP signaling in rabbit parotid acinar cells. (共著)
H Sugiya; H Michikawa; Y Mitsui; J Fujita-Yoshigaki; M Hara-Yokoyama; S Furuyama
European Journal of Morphology, 1998, Not refereed, Not invited

Translocation of Arf1 to the secretory granules in rat parotid acinar cells(共著)
Y Dohke; M Hara-Yokoyama; J Fujita-Yoshigaki; RA Kahn; Y Kanaho; S Hashimoto; H Sugiya; S Furuyama
Archives of Biochemistry and Biophysics, 1998, Not refereed, Not invited

Divergence and cornvergence in regulated exocytosis : The Characteristics of cAMP-dependent enzyme secretion of parotid salivary acinar cells.
Fujita-Yoshigaki J
Cellular Signalling, 1998, Not refereed, Not invited
Lead

Vesicle-associated membran protein 2 is essential for cAMP-regulated exocytosis in rat parotid acinar cells : the inhibition of cAMP-dependent amylase release by botulinum neurotoxin B. (共著)
Fujita-Yoshigaki J; Dohke Y; Hara-Yokoyama M; Kamata Y; Kozaki S; Furuyama S; Sugiya H
Journal of Biological Chemistry, 1996, Not refereed, Not invited
Lead

A constitutive effect or region on the C-terminal side of switch I of the Ras protein
J FUJITAYOSHIGAKI; M SHIROUZU; Y ITO; S HATTORI; S FURUYAMA; S NISHIMURA; S YOKOYAMA
J. Biol. Chem., 1995, Not refereed, Not invited

MUTATIONS THAT ABOLISH THE ABILITY OF HA-RAS TO ASSOCIATE WITH RAF-1
M SHIROUZU; H KOIDE; J FUJITAYOSHIGAKI; H OSHIO; Y TOYAMA; K YAMASAKI; SA FUHRMAN; E VILLAFRANCA; S YOKOYAMA; Y KAZIRO
ONCOGENE, Aug. 1994, Not refereed, Not invited

Site-directed mutagenesis fluorescence and two-dimensional NMR studies on microenvironments of effector region aromatic residues of human c-Ha-Ras protein. (共著)
K YAMASAKI; M SHIROUZU; Y MUTO; J FUJITAYOSHIGAKI; H KOIDE; Y ITO; G KAWAI; S HATTORI; S YOKOYAMA; S NISHIMURA; T MIYAZAWA
Biochemistry, 1994, Not refereed, Not invited

C-HA-RAS MUTANTS WITH POINT MUTATIONS IN GLN-VAL-VAL REGION HAVE REDUCED INHIBITORY ACTIVITY TOWARD CATHEPSIN-B
T HIWASA; J FUJITAYOSHIGAKI; M SHIROUZU; H KOIDE; T SAWADA; S SAKIYAMA; S YOKOYAMA
CANCER LETTERS, May 1993, Refereed, Not invited

A glutamic acid residue at position 31 of Ras protein is essential for neurite outgrowth of PC12 cells and the stimulation of GTPase activity by GAP^Ras. (共著)
M SHIROUZU; J FUJITAYOSHIGAKI; Y ITO; H KOIDE; S NISHIMURA; S YOKOYAMA
Oncogene, 1992, Not refereed, Not invited

Azatyrosine inhibits neurit outgrowth of PC12 cells induced by oncogenic Ras. (共著)
J FUJITAYOSHIGAKI; S YOKOYAMA; N SHINDOOKADA; S NISHIMURA
Oncogene, 1992, Not refereed, Not invited

Guanine-nucleotide binding activity, interaction with GTPase activating protein and solution conformation of the human C-Ha-Ras protein catalytic domain are retained upon deletion of C-terminal 18 amino acid residues. (共著)
J FUJITAYOSHIGAKI; Y ITO; K YAMASAKI; Y MUTO; T MIYAZAWA; S NISHIMURA; S YOKOYAMA
Jourmal of Protein Chemistry, 1992, Not refereed, Not invited

Identification of amino acid residues of Ras protein that are essential for signal-transducing activity but not for enhancement of GTPase activity by GAP. (共著)
J FUJITAYOSHIGAKI; M SHIROUZU; H KOIDE; S NISHIMURA; S YOKOYAMA
FEBS Letter, 1991, Not refereed, Not invited

Conformational change of effector-region residues in antiparallel β-sheet of human c-Ha-ras protein on GDP→GTPγs exchange : a two-dimensional NMR study. (共著)
K YAMASAKI; G KAWAI; Y ITO; Y MUTO; J FUJITA; T MIYAZAWA; S NISHIMURA; S YOKOYAMA
Biochemical and Biophysical Research Communications, 1989, Not refereed, Not invited

Potentiation of cystein proteinase-inhibitor activity of full-length Ha-┣DBras(/)-┫DB oncogene products by denaturation-renaturation. (共著)
T HIWASA; S YOKOYAMA; J FUJITA; E KOMINAMI; N KATUNUMA; S SAKIYAMA
Biochemistry Inteynational, 1989, Not refereed, Not invited

Inhibition of cathepsin L-induced degradation of epidermal growth factor receptors by C-Ha-┣DBras(/)-┫DB gene products. (共著)
T HIWASA; S SAKIYAMA; S YOKOYAMA; JM HA; J FUJITA; S NOGUCHI; Y BANDO; E KOMINAMI; N KATUNUMA
Biochemical and Biophysical Research Communications, 1988, Not refereed, Not invited

ヒト歯髄におけるBMP-1を起点としたGlcCeraseの細胞内局在と酵素活性の制御
室町 幸一郎; 中野 令; 吉垣 純子; 杉谷 博士; 石井 信之
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, Jun. 2020

慢性歯周炎による唾液腺のアポトーシス性萎縮メカニズム
鹿山武海; 鹿山武海; 左合(伊藤)美紗; 吉垣純子; 浪花真子; 人見涼露; 氏原泉; 臼井通彦; 中島啓介; 小野堅太郎
日本生理学雑誌(Web), 2020

Involvement of Anion-permeable Aquaporin-6 in Osmotic Lysis of Parotid Secretory Granules
Miwako Matsuki-Fukushima; Masataka Murakami; Junko Fujita-Yoshigaki; Osamu Katsumata-Kato; Megumi Yokoyama; Hiroshi Sugiya
JOURNAL OF GENERAL PHYSIOLOGY, Aug. 2013, Not refereed, Not invited

Involvement of the endocytosis pathway in secretory granule formation as revealed by fluorescent dye-uptake into rat parotid acinar cells
Osamu Katsumata-Kato; Megumi Yokoyama; Miwako Matsuki-Fukushima; Junko Fujita-Yoshigaki
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, Not refereed, Not invited

Development of secretory granule-specific pH indicator in rat parotid acinar cells
Miwako Matsuki-Fukushima; Osamu Katsumata-Kato; Megumi Yokoyama; Junko Fujita-Yoshigaki
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, Not refereed, Not invited

Regulation of cGMP level by phosphodiesterases 1 and 2 in rabbit submandibular gland cells
O. Hiromi Michikawa; Junko Fujita-Yoshigaki; Tomoyoshi Yoshigaki; Hiroshi Sugiya; Shunsuke Furuyama
CELL STRUCTURE AND FUNCTION, Jun. 2005, Not refereed, Not invited

ラット耳下腺分泌顆粒におけるAQP6の存在
松木 美和子; 橋本 貞充; 下野 正基; 吉垣 純子; 古山 俊介; 杉谷 博士
歯科基礎医学会雑誌, Sep. 2003, Not refereed, Not invited

VAMP2-binding proteins at secretary granules in rat parotid glands.
J. Yoshigaki; S. Furuyama; H. Sugiya
JOURNAL OF DENTAL RESEARCH, Jun. 2003, Not refereed, Not invited

Localization and function of aquaporin 5 in rat parotid secretory granules.
H. Sugiya; M. Matsuki; S. Hashimoto; M. Shimono; M. Murakami; J. Yoshigaki; S. Furuyama
JOURNAL OF DENTAL RESEARCH, Jun. 2003, Not refereed, Not invited

耳下腺分泌顆粒膜におけるアクアポリン5の機能
松木 美和子; 橋本 貞充; 下野 正基; 吉垣 純子; 古山 俊介; 杉谷 博士
歯科基礎医学会雑誌, Sep. 2002, Not refereed, Not invited

The role of VAMP2-containing complex in cAMP-dependent amylase secretion from parotid acinar cells
J Yoshigaki; S Furuyama; H Sugiya
MOLECULAR BIOLOGY OF THE CELL, Nov. 2001, Not refereed, Not invited

唾液腺におけるHPC-1/シンタキシン1Aの局在
杉谷 博士; 橋本 貞充; 吉垣 純子; 古山 俊介
歯科基礎医学会雑誌, Aug. 2001, Not refereed, Not invited

Involvement of SMGs in cAMP-dependent exocytosis of amylase.
Y Dohke; M Hara-Yokoyama; J Yoshigaki; H Sugiya; S Furuyama
JOURNAL OF DENTAL RESEARCH, May 2000, Not refereed, Not invited

VAMP2-containing complex at secretory granules in parotid acinar cells.
J Yoshigaki; Y Dohke; M Hara-Yokoyama; S Furuyama; H Sugiya
JOURNAL OF DENTAL RESEARCH, May 2000, Not refereed, Not invited

Involvement of Arf1 in cAMP-dependent exocytosis of amylase.
Y Dohke; M Hara-Yokoyama; J Fujita-Yoshigaki; H Sugiya; S Furuyama
JOURNAL OF DENTAL RESEARCH, 2000, Not refereed, Not invited

Translocation of Arf1 to the parotid secretory granules.
Y Dohke; M Hara-Yokoyama; J Fujita-Yoshigaki; H Sugiya; S Furuyama
JOURNAL OF DENTAL RESEARCH, 1998, Not refereed, Not invited

Interaction of SNARE proteins in parotid acinar cells.
J Fujita-Yoshigaki; Y Dohke; M Hara-Yokoyama; S Furuyama; H Sugiya
JOURNAL OF DENTAL RESEARCH, 1998, Not refereed, Not invited

ウサギ耳下腺一酸化窒素合成酵素の酵素学的性質
三井 由香; 吉垣 純子; 横山 三紀; 通川 広美; 古山 俊介; 杉谷 博士
日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

VAMP-2 is required to cAMP-dependent exocytosis of parotid acinar cells
J Yoshigaki; M Yokoyama; Y Dohke; S Furuyama; H Sugiya
JOURNAL OF DENTAL RESEARCH, 1996, Not refereed, Not invited

Low molecular weight GTP-binding proteins in rat parotid acinar cells
Y Dohke; M Yokoyama; J Yoshigaki; S Furuyama; H Sugiya
JOURNAL OF DENTAL RESEARCH, 1996, Not refereed, Not invited

徹底レクチャー 唾液・唾液腺
日本唾液腺学会, Contributor, 日本唾液腺学会 編
金原出版株式会社, Dec. 2016, Not refereed
9784307030557

子どもの歯に強くなる本
木村光孝, Joint work, 木村光孝 監修
クインテッセンス出版株式会社, Dec. 2012, Not refereed
9784781202921

癌化のシグナル伝達機構
吉垣純子; 横山茂之, Contributor, Ras蛋白質の動的な機能構造, 吉垣純子,横山茂之
中外医学社, 1994, Not refereed

Measurement of lysosomal protease activities in secretory granules
MIyuki Toda; Junko Fujita-Yoshigaki; Arata Nagasaka; Yasuhiko Bando; Osamu Amano
APPW2025, Mar. 2025, Not invited

年齢の違いによる塩味嗜好と唾液中ナトリウムイオンの関係
横山 愛; 浜野 亜紀子; 加藤 治; 吉垣 純子
第68回日本唾液腺学会学術集会, Dec. 2024

塩味閾値および塩味嗜好に対する唾液中イオンの影響
吉垣純子; 浜野亜紀子; 横山愛; 加藤治
第３回日本唾液ケア研究会学術集会, Nov. 2024, Not invited

ラット唾液腺におけるcathepsin Bの局在
戸田 みゆき; 小野澤 豪; 長坂 新; 坂東 康彦; 吉垣 純子; 天野 修
第66回歯科基礎医学会学術大会, Nov. 2024, Not invited

唾液腺への組織傷害で誘導された腺房細胞増殖因子の作用機序の検討
横山 愛; 加藤 治; 吉垣 純子
第66回歯科基礎医学会学術大会, Nov. 2024, Not invited

唾液腺由来HSY細胞からの細胞外小胞の分離
加藤 治; 横山 愛; 吉垣 純子
第66回歯科基礎医学会学術大会, Nov. 2024, Not invited

唾液腺細胞上清からの細胞外小胞の検出
鯨岡創一郎; 加藤治; 横山愛; 吉垣純子
第24回日本大学口腔科学会学術大会, Sep. 2024, Not invited

唾液腺の組織傷害応答におけるBMP-2の役割
植木克昌; 横山愛; 加藤治; 吉垣純子
第24回日本大学口腔科学会学術大会, Sep. 2024, Not invited

塩味における唾液中イオンの影響
浜野亜紀子; 横山愛; 加藤治; 吉垣純子
第24回日本大学口腔科学会学術大会, Sep. 2024, Not invited

ヒト歯髄においてGBA1はBMP-1によって核移行しcyclin A2の発現を調節する
室町幸一郎; 中野令; 吉垣純子; 杉谷博士
第15回日本CCNファミリー研究会, Aug. 2024, Not invited

マウス耳下腺排泄導管結紮時に発現するBMP2の役割
横山 愛; 戸田 みゆき; 加藤 治; 吉垣 純子
第101回日本生理学会大会, Mar. 2024, Not invited

耳下腺における新旧分泌顆粒の刺激応答性の経時的変化
戸田 みゆき; 横山 愛; 加藤 治; 吉垣 純子
第101回日本生理学会大会, Mar. 2024, Not invited

塩味に対する唾液中のNa+およびK+の影響
横山愛; 浜野亜紀子; 加藤治; 吉垣純子
第67回日本唾液腺学会学術集会, Nov. 2023, Not invited

組織傷害が誘導する唾液腺の再生促進因子の検索
吉垣純子; 横山愛; 戸田みゆき; 加藤治
第65回歯科基礎医学会学術大会アップデートシンポジウム, Sep. 2023, Invited

プロカテプシンBによって捉えた耳下腺の新規生成顆粒の分泌能
加藤治; 横山愛; 戸田みゆき; 吉垣純子
第65回歯科基礎医学会学術大会, Sep. 2023, Not invited

耳下腺分泌顆粒の時間経過による刺激反応性の変化
戸田みゆき; 横山愛; 加藤治; 吉垣純子
第65回歯科基礎医学会学術大会, Sep. 2023, Not invited

塩味閾値および塩味嗜好濃度に対する唾液成分の影響
浜野亜紀子; 横山愛; 加藤治; 吉垣純子
第23回日本大学口腔科学会学術大会, Sep. 2023, Not invited

The role of Ca2+-dependent aggregation of cargo proteins in selective transport of salivary acinar cells
Fujita-Yoshigaki J; Yokoyama M; Katsumata-Kato O
The 100th Anniversary Annual Meeting of The Physiological Society of Japan, Mar. 2023, 日本生理学会, Not invited

プロカテプシンBを指標にしたラット耳下腺新規生成顆粒の分泌能の検討
加藤治,横山愛,吉垣純子
第66回日本唾液腺学会学術集会, Nov. 2022, 日本唾液腺学会, Not invited

耳下腺腺房細胞における分泌タンパク質の選別機構
吉垣純子,横山愛,加藤治
第64回歯科基礎医学会学術大会, Sep. 2022, 歯科基礎医学会, Not invited

BMP2は耳下腺腺初代培養細胞の細胞増殖能を高める
横山愛,加藤治,吉垣純子
第64回歯科基礎医学会学術大会, Sep. 2022, 歯科基礎医学会, Not invited

プロカテプシンBを指標にしたラット耳下腺における新規生成顆粒の分泌能の検討
加藤治,横山愛,吉垣純子
第64回歯科基礎医学会学術大会, Sep. 2022, 歯科基礎医学会, Not invited

耳下腺導管結紮法による唾液腺回復因子の検索
横山愛,加藤治,吉垣純子
第34回唾液腺談話会, Sep. 2022, Invited

唾液腺細胞内輸送の多重蛍光解析-ChemiDoc MPイメージングシステムの活用
吉垣 純子,横山 愛,加藤 治
第22回日本大学口腔科学会学術大会, Sep. 2022, 日本大学口腔科学会, Not invited

容量感受性陰イオンチャネルTtyhの唾液腺における細胞内局在
福島美和子,吉垣純子,佐藤慶太郎,藤川芳織,井上知,野中直子
第127回日本解剖学会総会・全国学術集会, Mar. 2022, 日本解剖学会, Not invited

唾液腺導管結紮によって誘導されるBMP2の発現とその作用の検討
横山 愛,加藤 治,吉垣 純子
第65回日本唾液腺学会学術集会, Nov. 2021, 日本唾液腺学会, Not invited

ラット耳下腺の顆粒形成・成熟と臓器アミラーゼ比活性の関係
加藤 治,横山 愛,吉垣 純子
第63回歯科基礎医学会学術大会, Oct. 2021, 歯科基礎医学会, Not invited

傷害された唾液腺が発現するBMP2の役割
横山 愛,加藤 治,吉垣 純子
第63回歯科基礎医学会学術大会, Oct. 2021, 歯科基礎医学会, Not invited

耳下腺腺房細胞におけるHaloTag融合分泌タンパク質の選別輸送効率の測定
吉垣 純子,加藤 治,横山 愛
第63回歯科基礎医学会学術大会, Oct. 2021, 歯科基礎医学会, Not invited

Effect of the cysteine protease inhibitor cystatin D on growth of oral cancer cells
吉垣純子,横山愛,加藤治
第126回日本解剖学会総会・全国学術大会/第98回日本生理学会大会合同大会, Mar. 2021, 日本解剖学会，日本生理学会, Not invited

Selective transport of secretory proteins to the regulated and constitutive pathways in salivary acinar cells
吉垣純子, 横山愛, 加藤治
第62回歯科基礎医学会学術大会, Sep. 2020, 一般社団法人歯科基礎医学会, Not invited

唾液腺の分泌機能を亢進する因子の検索
横山愛, 加藤治, 吉垣純子
第62回歯科基礎医学会学術大会, Sep. 2020, 一般社団法人歯科基礎医学会, Invited

Simulation analysis of selective transport of cystatin D-fused HaloTag proteins to regulated and constitutive secretory pathways
Junko Fujita-Yoshigaki; Megumi Yokoyama; Osamu Katsumata-Kato
第97回日本生理学会大会, Mar. 2020, 日本生理学会, Not invited

Secretion of amylase and procathepsin B from newly-formed secretory granules in rat parotid acinar cells
Katsumata-Kato O; Yokoyama M; Fujita-Yoshigaki J
第97回日本生理学会大会, Mar. 2020, 日本生理学会, Not invited

耳下腺腺房細胞における外来分泌タンパク質の選別輸送
吉垣純子,横山愛,加藤治
第64回日本唾液腺学会学術集会, Dec. 2019, 日本唾液腺学会, Not invited

共催シンポジウム報告「唾液腺の基礎研究から再生医療へ」
吉垣純子,天野修
第64回日本唾液腺学会学術大会, Dec. 2019, 日本唾液腺学会, Not invited

唾液腺腺房細胞初代培養系における機能維持と脱分化の分岐点
吉垣 純子
第56回日本口腔組織培養学会学術大会, Nov. 2019, 日本口腔組織培養学会, Invited

慢性歯周炎による唾液腺のアポトーシス性萎縮メカニズム
鹿山武海,左合-伊藤美紗,吉垣純子,浪花真子,人見涼露,氏原泉,臼井通彦,中島啓介,小野堅太郎
第70回西日本生理学会, Nov. 2019, Not invited

耳下腺傷害により増加するシグナル分子の検索
横山愛,加藤治,吉垣純子
第19回日大口腔科学会学術大会, Sep. 2019, 日大口腔科学会, Not invited

Secretory proteins without transport signal are retained in the granules
Katsumata-Kato O; Yokoyama M; Fujita-Yoshigaki J
97th General Session & Exhibition of the IADR, Jun. 2019, International Association of Dental Research, Not invited

Relationship of calcium mobilization and salivation in two mouse strains
Fujita-Yoshigaki J; Sakurai H; Yokoyama M; Katsumata-Kato O
97th General Session & Exhibition of the IADR, Jun. 2019, International Association of Dental Research, Not invited

Search for salivary gland function-promoting factor in microarray analysis
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
97th General Session & Exhibition of the IADR, Jun. 2019, International Association of Dental Research, Not invited

Role of cysteine protease inhibitors in malignancy of oral squamous cell carcinoma
Junko Fujita-Yoshigaki; Megumi Yokoyama; Osamu Katsumata-Kato
9th FAOPS Congress, Mar. 2019, Federation of the Asian and Oceanian Physiological Societies, Not invited

Procathepsin B without mannose-6-phosphate is released from secretory granules
Katsumata-kato O; Yokoyama M; Fujita-Yoshigaki J
9th FAOPS Congress, Mar. 2019, Federation of the Asian and Oceaninan Physiological Societies, Not invited

マウス唾液腺における傷害に対する代償作用に関わる因子の検索
横山 愛,加藤 治,吉垣 純子
第63回日本唾液腺学会学術集会, Dec. 2018, 日本唾液腺学会, Not invited

Difference of calcium mobilization in two mouse strains that have different abilities to secrete saliva
Hajime Sakurai; Hiroaki Ogawa; Megumi Yokoyama; Osamu Kato; Junko Yoshigaki
The 60th Annula Meeting of Japanese Association for Oral Biology, Sep. 2018, 歯科基礎医学会, Not invited

Retrieval of enhancing factor for salivation by exhaustive gene expression analysis
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
The 60th Annual Meeting of Japanese Association for Oral Biology, Sep. 2018, 歯科基礎医学会, Not invited

Change in expression pattern of micro RNA in the primary culture of parotid acinar cells
Hiroaki Ogawa; Hajime Sakurai; Megumi Yokoyama; Osamu Katsumata-Kato; Junko Fujita-Yoshigaki
The 60th Annual Meeting of Japanese Association for Oral Biology, Sep. 2018, 歯科基礎医学会, Not invited

Tranport and secretion of procathepsin B in immature secretory granules of rat parotid acinar cells
Katsumata-Kato O; Yokoyama M; Fujita-Yoshigaki J
The 60th Annual Meeting of Japanese Association for Oral Biology, Sep. 2018, 歯科基礎医学会, Not invited

Regulation of transport pathway of cystatin D in salivary acinar cells.
Junko Yoshigaki; Megumi Yokoyama; Osamu Kato
The 95th Annual Meeting of the Physiological Society of Japan, Mar. 2018, 日本生理学会, Not invited

ラット耳下腺分泌顆粒の成熟過程における膜のリモデリングと分泌能との関係
加藤 治,横山 愛,吉垣純子
第62回日本唾液腺学会学術集会, Nov. 2017, 日本唾液腺学会, Not invited

Changes in the expression pattern of micro RNA in response to tissue injury in parotid acinar cells
Ogawa H; Sakurai H; Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
The 59th Annual Meeting of Japanese Association for Oral Biology, Sep. 2017, 歯科基礎医学会, Not invited

Comparison of calcium mobilization between the two mouse strains that have different capacities of saliva secretion
Sakurai H; Ogawa H; Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
The 59th Annual Meeting of Japanese Association for Oral Biology, Sep. 2017, 歯科基礎医学会, Not invited

The effect of unilateral salivary gland injury in the opposite salivary gland
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
The 59th Annual Meeting of Japanese Association for Oral Biology, Sep. 2017, 歯科基礎医学会, Not invited

ラット耳下腺の分泌顆粒-未成熟顆粒間の脂質解析
加藤治,槿山愛,吉垣純子
第17回日本大学口腔科学会学術大会, Sep. 2017, Not invited

Mechanism for selective transport of secretory proteins into secretory granules of parotid acinar cells
Fujita-Yoshigaki J; Yokoyama M; Katsumata-Kato O
4th International Symposium on Salivary Glands in Honor of Niels Stensen, Nov. 2016, Invited

The role of membrane microdomains for granule maturation in the rat parotid gand
Katsumata-Kato O; Yokoyama M; Fujita-Yoshigaki J
4th International Symposium on Salivary glands in Honor of Niels Stensen, Nov. 2016, Not invited

傷害側唾液腺と非傷害側唾液腺における相互作用
横山愛,加藤治,吉垣純子
第58回歯科基礎医学会学術大会, Aug. 2016, Not invited

ラット耳下腺分泌顆粒と未成熟顆粒間におけるLC-MS脂質解析
加藤治,横山愛,吉垣純子
第58回歯科基礎医学会学術大会, Aug. 2016, Not invited

Gene expression changes during primary culture of salivary acinar cells
吉垣純子,横山愛,加藤治
The 93rd Annual Meeting of the Physiological Society of Japan, Mar. 2016, 日本生理学会, Not invited

片側唾液腺傷害後における非傷害側のnestinの発現
横山愛,加藤治,吉垣純子
第60回日本唾液腺学会学術集会, Dec. 2015, Not invited

唾液腺傷害時と回復時における前駆細胞マーカーの発現
横山愛,加藤治,吉垣純子
第57回歯科基礎医学会学術大会, Sep. 2015, Not invited

ラット耳下腺分泌顆粒のタンパク質濃縮機構における膜ドメインの関与
加藤治,横山愛,吉垣純子
第57回歯科基礎医学会学術大会, Sep. 2015, Not invited

Selective transport of proteins into secretory granules of salivary acinar cells
Junko Fujita-Yoshigaki; Megumi Yokoyama; Osamu Katsumata-Kato
第57回歯科基礎医学会学術大会サテライトシンポジウム, Sep. 2015, 歯科基礎医学会, Invited

内膜系オルガネラの形成・輸送機構
第57回歯科基礎医学会学術大会サテライトシンポジウム, Sep. 2015, Not invited

耳下腺における唾液タンパク質シスタチンDの調節性分泌への輸送機構
吉垣純子,横山愛,加藤治
第59回日本唾液腺学会, Dec. 2014, Not invited

ラット耳下腺分泌顆粒に特異的なpHインジケーターの合成と応用
福島美和子,加藤治,横山愛,三島健二,吉垣純子
第59回日本唾液腺学会学術集会, Dec. 2014, Not invited

Sorting mechanism of secretory proteins into regulated and constitutive secretory pathways in salivary glands
吉垣純子,横山愛,加藤治
第56回歯科基礎医学会学術大会, Sep. 2014, Not invited

ラットの唾液腺分泌型IgAへの運動による影響
栗本勇輝,山本裕子,東雅啓,猿田樹理,榎木恵一
第56回歯科基礎医学会学術大会, Sep. 2014, Not invited

耳下腺および膵外分泌腺アミラーゼ開口分泌におけるMARCKSシグナリングの関与
佐藤慶太郎,成田貴則,杉谷博士
第56回歯科基礎医学会学術大会, Sep. 2014, Not invited

生体内イメージングによる開口分泌におけるアクチン重合機構の解析
設楽彰子,田隈泰信
第56回歯科基礎医学会学術大会, Sep. 2014, Not invited

唾液腺由来BDNFの全身への移行についての検討 -第一報-
東雅啓,猿田樹理,杉本昌弘,近藤裕介,林隆司,山本裕子,清水智子,栗本勇輝,斎藤一郎,榎木恵一
第56回歯科基礎医学会学術大会, Sep. 2014, Not invited

Sorting Mechanism of Proteins to Secretory Granules in Salivary Glands
Junko Fujita-Yoshigaki; Miwako Matsuki-Fukushima; Megumi Yokoyama; Osamu Katsumata-Kato
92nd General Session & Exhibition of the IADR, Jun. 2014, Not invited

Maintenance of secretory proteins during granule maturation in parotid glands
Katsumata-kato O; Yokoyama M; Fujita-Yoshigaki J
92nd General Session & Exhibition of the IADR, Jun. 2014, Not invited

Expression of nestin during injury and recovery in parotid gland
Yokoyama M; Katsumata-Kato O; Fujita-Yoshigaki J
92nd General Session & Exhibition of the IADR, Jun. 2014, Not invited

Expression of nestin in injured salivary gland
Yokoyama M; Katsumata-Kato O; Matsuki-Fukushima M; Fujita-Yoshigaki J
第91回日本生理学会大会, Mar. 2014, Not invited

Maintenance of secretory proteins during maturation of rat parotid secretory granules
Katsumata-Kato O; Yokoyama M; Matsuki-Fukushima M; Fujita-Yoshigaki J
The 91st Annual Meeting of the Physiological Society of Japan, Mar. 2014, Not invited

ラット耳下腺分泌顆粒に特異的なpHインジケーターの合成と応用
福島美和子,加藤治,横山愛,吉垣純子
第55回歯科基礎医学会学術大会, Sep. 2013, Not invited

耳下腺における唾液タンパク質の分泌顆粒への輸送機構
吉垣純子,福島美和子,横山愛,加藤治
第55回歯科基礎医学会サテライトシンポジウム, Sep. 2013, Invited

Development of secretory granule-specific pH indicator in rat parotid acinar cells
Matsuki-Fukushima M; Katsumata-Kato O; Yokoyama M; Fujita-yoshigaki J
The 90th Annual Meeting of the Physiological Society of Japan, Mar. 2013, Not invited

唾液腺におけるタンパク質の分泌顆粒への輸送機構
吉垣純子,福島美和子,横山愛,加藤治
第57回日本唾液腺学会, Dec. 2012, Not invited

マウス耳下腺導管結紮によるnestinの発現
横山愛,加藤治,福島美和子,吉垣純子
第54回歯科基礎医学会学術大会, Sep. 2012, Not invited

耳下腺腺房細胞の分泌顆粒形成におけるエンドサイトーシスの関与
加藤治,福島美和子,成田貴則,杉谷博士,吉垣純子
第56回日本唾液腺学会学術大会, Dec. 2011, 文京学院大学（東京）, Not invited

耳下腺腺房細胞における分泌顆粒への輸送機構
吉垣純子,福島美和子,横山愛,加藤治
第53回歯科基礎医学会, Oct. 2011, Not invited

Expression of neural stem cell marker nestin in parotid acinar cell
Yokoyama M; Kato O; Fukushima M; Yoshigaki J
The 89th Annual Meeting of the Physiological Society of Japan, Mar. 2011, Not invited

Transient expression of claudin-4 in parotid acinar cells in response to tissue injuries.
Fujita-Yoshigaki J
The Gordon Research Conference on Salivary Glands & Exocrine Biology, Feb. 2011, Not invited

Transient expression of claudin-4 in salivary glands induced by γ-irradiation
Fujita-Yoshigaki J; Narita T; Sugiya H
88th General Session & Exhibition of the IADR, Jul. 2010, Not invited

唾液腺における分化の可塑性—腺房細胞脱分化シグナルの解明
第51回歯科基礎医学会サテライトシンポジウム, Sep. 2009, Not invited

唾液腺細胞における分化の可塑性と機能回復への応用
第9回歯科基礎医学会ライオン賞受賞講演, Sep. 2009, Not invited

Parotid acinar cells transiently change to duct-like cells during epithelial-mesenchymal transition
Fujita-Yoshigaki J; Qi B; Narita T; Sugiya H
The 11th International Symposium on Exocrine Secretion, Jul. 2009, Not invited

ラット顎下腺由来SMIE細胞におけるタイト結合タンパク質の発現と機能
Yoshigaki J; Sugiya H
第50回歯科基礎医学会, Sep. 2008, Not invited

Change of claudin expression during dedifferentiation of parotid acinar cells
Yoshigaki J; Sugiya H
The 85th Annual Meeting of the Physiological Society of Japan, Mar. 2008, Not invited

Inhibition of Src and p38 MAP Kinases Suppressed Dedifferentiation of Primary Cultured Parotid Acinar Cells.
Fujita-Yoshigaki J; Matsuki-Fukushima M; Sugiya H
Annual Meeting of the American Society for Cell Biology, Dec. 2007, Not invited

唾液腺腺房細胞におけるクローディンの発現変化に関わるシグナル
吉垣純子; 福島美和子; 杉谷博士
第80回日本生化学会第30回日本分子生物学会合同大会, Dec. 2007, Not invited

耳下腺腺房細胞初代培養細胞における脱分化シグナル
吉垣純子,福島美和子,三井烈,佐藤慶太郎,杉谷博士
第49回歯科基礎医学会, Aug. 2007, Not invited

唾液腺における開口放出の分子機構 –遺伝子及びタンパク質レベルの解析
第46回歯科基礎医学会若手サテライトシンポジウム, Sep. 2004, Invited

耳下腺腺房細胞におけるアミラーゼ開口放出の制御機構
第44回日本唾液腺学会, Dec. 1999, Not invited

Molecular mechanism of regulated exocytosis in salivary glands.
Fujita-Yoshigaki J; Dohke Y; Hara-Yokoyama M; Furuyama S; Sugiya H
Proc Australian Physiol Pharmacol Soc 29, Sep. 1998, Invited

ラット耳下腺腺房細胞のアミラーゼ分泌における開口放出関連タンパク質の役割
吉垣純子; 杉谷博士; 古山俊介
第67回日本生化学大会, Sep. 1994, Not invited

ラット耳下腺腺房細胞に存在する開口放出関連タンパク質
吉垣 純子
第71回日本生理学会大会, Mar. 1994, Not invited

日本生化学会

日本分子生物学会

日本生理学会

歯科基礎医学会

International Association for Dental Research

日本唾液腺学会

唾液腺における分泌顆粒の品質管理とその破綻が招く口腔乾燥症発症機序の解明
日本学術振興会, 科学研究費助成事業, Apr. 2025 - Mar. 2029
吉垣 純子

歯髄においてBMP-1-GBA1経路が細胞増殖とDNA複製に寄与する機構の解明
日本学術振興会, 科学研究費助成事業, Apr. 2024 - Mar. 2027
室町 幸一郎; 吉垣 純子; 中野 令

新規塩素チャネルTtyh3分子の交感神経性唾液分泌における役割の解明
日本学術振興会, 科学研究費助成事業, Apr. 2024 - Mar. 2027
福島 美和子; 井上 知; 佐藤 慶太郎; 野中 直子; 吉垣 純子

外分泌細胞における余剰分泌顆粒の安全な処理機構としてのクリノファジーの役割
日本学術振興会, 科研費基盤(C), Apr. 2021 - Mar. 2025
吉垣 純子

塩味閾値および塩味への嗜好に対する唾液成分の影響
ソルト・サイエンス研究財団, May 2023 - Mar. 2024

シスタチンの細胞内輸送経路の転換が引き起こす口腔がん進展・抑制作用
公益財団法人土屋文化振興財団, Nov. 2020 - Sep. 2021

シスタチンＤの口腔癌に対する抑制効果と作用点の解析
Apr. 2017 - Mar. 2020
吉垣純子

唾液腺における分泌タンパク質の選別輸送シグナルの同定
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2013 - Mar. 2016
吉垣純子

唾液腺障害時に誘導される臓器間コミュニケーションを担うエクソソームの検索
一般財団法人 濱口生化学振興財団, Jan. 2015 - Dec. 2015

蛍光リガンド結合タンパク質の発現による分泌顆粒の形成・成熟・開口放出過程の可視化
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2011 - Mar. 2013
YOSHIGAKI Junko

口腔乾燥症の早期診断および予防法の開発
Apr. 2011 - Mar. 2012
吉垣純子

唾液腺における開口放出調節タンパク質の相互作用
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2004 - Mar. 2006
杉谷博士

耳下腺腺房細胞における刺激依存性開口放出の分子機構
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2004 - Mar. 2006
YOSHIGAKI Junko

唾液腺における分泌関連分子の相互作用
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2001 - Mar. 2003
古山俊介

耳下腺腺房細胞においてcAMP依存性開口放出を制御するタンパク質の同定
日本学術振興会, 科学研究費助成事業, Apr. 2001 - Mar. 2003
吉垣 純子

耳下腺腺房細胞におけるVAMP2を介するアミラーゼ分泌の制御機構
日本学術振興会, 科学研究費助成事業, Apr. 1999 - Mar. 2001
吉垣 純子

外分泌における水電解質輸送と開口分泌の協調機構
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 1998 - Mar. 2001
村上政隆

舌下腺ムチン開口分泌の分子機構
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 1997 - Mar. 1999
杉谷博士

耳下腺腺房細胞においてVAMP-2と相互作用するタンパク質の検索
日本学術振興会, 科学研究費助成事業, Apr. 1997 - Mar. 1999
吉垣純子

耳下腺腺房細胞におけるアミラーゼ開口放出の分子機構
日本学術振興会, 科学研究費助成事業, Apr. 1996 - Mar. 1997
吉垣純子

耳下腺腺房細胞に存在する開口放出関連タンパク質の役割
日本学術振興会, 科学研究費助成事業, Apr. 1995 - Mar. 1996
吉垣純子

イソプロテレノール投与によるラット耳下腺細胞の分裂開始機構
日本学術振興会, 科学研究費助成事業, Apr. 1994 - Mar. 1995
吉垣純子