Tanaka Toru
| Department of Pharmacy | Assistant Professor |
Researcher Information
Research activity information
Paper
- ★Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
Biochimica et Biophysica Acta (BBA) - General Subjects, Jul. 2022, Refereed
Lead - Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
Neurochemistry International, Oct. 2020, Refereed
Lead - Enhanced Tau Protein Translation by Hyper-Excitation
Shunsuke Kobayashi; Toru Tanaka; Yoshiyuki Soeda; Akihiko Takashima
Frontiers in Aging Neuroscience, Nov. 2019, Refereed, Not invited - Mechanism responsible for inhibitory effect of indirubin 3'-oxime on anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells
Toru Tanaka; Misaki Kasai; Shunsuke Kobayashi
Experimental Cell Research, Sep. 2018, Refereed, Not invited
Lead - Indirubin 3′-oxime inhibits anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells
Toru Tanaka; Sachiyo Ohashi; Hiroaki Saito; Taira Wada; Tadashi Aoyama; Yoshimi Ichimaru; Shinichi Miyairi; Shunsuke Kobayashi
Biochemical and Biophysical Research Communications, Jan. 2018, Refereed, Not invited - Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation
Shunsuke Kobayashi; Toru Tanaka; Yoshiyuki Soeda; Osborne F. X. Almeida; Akihiko Takashima
EBIOMEDICINE, Jun. 2017, Refereed, Not invited - Four nucleocytoplasmic-shuttling proteins and p53 interact specifically with the YB-NLS and are involved in anticancer reagentinduced nuclear localization of YB-1
Toru Tanaka; Sachiyo Ohashi; Shunsuke Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2016, Refereed, Not invited - YB-1 gene expression is kept constant during myocyte differentiation through replacement of different transcription factors and then falls gradually under the control of neural activity.
Shunsuke Kobayashi; Toru Tanaka; Masamitsu Moue; Sachiyo Ohashi; Taishi Nishikawa
The International Journal of Biochemistry and Cell Biology, Aug. 2015, Refereed, Not invited - Indirubin derivatives alter DNA binding activity of the transcription factor NF-Y and inhibit MDR1 gene promoter
Toru Tanaka; Sachiyo Ohashi; Hiroaki Saito; Takashi Higuchi; Keiichi Tabata; Yasuhiro Kosuge; Takashi Suzuki; Shinichi Miyairi; Shunsuke Kobayashi
EUROPEAN JOURNAL OF PHARMACOLOGY, Oct. 2014, Refereed, Not invited - Roles of YB-1 under arsenite-induced stress: Translational activation of HSP70 mRNA and control of the number of stress granules
Toru Tanaka; Sachiyo Ohashi; Shunsuke Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Mar. 2014, Refereed, Not invited - Mechanism of YB-1-mediated translational induction of GluR2 mRNA in response to neural activity through nAChR
Toru Tanaka; Sachiyo Ohashi; Masamitsu Moue; Shunsuke Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jul. 2012, Refereed, Not invited - Translational level of acetylcholine receptor alpha mRNA in mouse skeletal muscle is regulated by YB-1 in response to neural activity
Sachiyo Ohashi; Masamitsu Moue; Toni Tanaka; Shunsuke Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2011, Refereed, Not invited - YB-1 Binds to GluR2 mRNA and CaM1 mRNA in the Brain and Regulates their Translational Levels in an Activity-Dependent Manner
Toru Tanaka; Sachiyo Ohashi; Tomoko Funakoshi; Shunsuke Kobayashi
CELLULAR AND MOLECULAR NEUROBIOLOGY, Oct. 2010, Refereed, Not invited
MISC
- 7-Hydorxyindirubin is capable of specifically inhibiting anticancer drug-induced YB-1 nuclear translocation without showing cytotoxicity in HepG2 hepatocellular carcinoma cells
Toru Tanaka; Hiroaki Saito; Shinichi Miyairi; Shunsuke Kobayashi
Biochemical and Biophysical Research Communications, Mar. 2021, Refereed, Not invited
Lead - Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
Neurochemistry International, 23 Jul. 2020, Refereed, Not invited
Lectures, oral presentations, etc.
- ★樹状突起におけるTauの局所翻訳と過剰リン酸化
田中 融; 大橋 祥世; 小林 俊亮
日本薬学会 第１４３年会, Mar. 2023, 日本薬学会 - ★Dendritic distribution of CDK5 mRNA and p35 mRNA, and glutamate-responsive increase of CDK5/p25 complex contribute to Tau hyperphosphorylation
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
The 45th Annual Meeting of the Molecular Biology Society of Japan, Dec. 2022, 日本分子生物学会 - ★Specific inhibition of YB-1 nuclear translocation and cancer exacerbation-related gene expression by indirubin derivatives
Toru Tanaka
日本薬学会第１４２年会, Mar. 2022 - ★The novel splice variant of KANSL1 mRNA affects the translation of tau mRNA
Toru Tanaka
The 44th Annual Meeting of the Molecular Biology Society of Japan, Dec. 2021, The Molecular Biology Society of Japan, Not invited - Effect of calcium ions on the aggregation of highly phosphorylated tau
田中 融; 大橋 祥世; 小林 俊亮
日本薬学会第144年会, Mar. 2024 - A novel 3'-UTR variant of KANSL1 mRNA has a region complementary to tau mRNA and activates its translation.
田中 融; 大橋 祥世; 小林 俊亮
第４６回 日本分子生物学会年会, Dec. 2023, Not invited - YB-1核移行を特異的に阻害するがん増悪抑制薬の探索
日本薬学会 第141年会, Mar. 2021, Not invited - グルタミン酸刺激に応じた樹状突起GSK3βの活性化とタウの過剰リン酸化
第43回 日本分子生物学会年会, Dec. 2020, Not invited - 3次元ヒト鼻腔透明モデルを用いた温度感受性in situゲル剤の鼻腔内滞留性の定量的評価法の開発
第64回 日本薬学会 関東支部大会, Sep. 2020, 日本薬学会関東支部, Not invited - 肝臓におけるYB-1のポリソーム結合性に影響を与える新奇lncRNA
第93回 日本生化学会大会, Sep. 2020, Not invited - YB-1の核移行を標的としたがんの増悪抑制
田中 融; 小林 峻亮
日本薬学会 第１４０年会, Mar. 2020, 日本薬学会, Not invited - 刺激に応じた樹状突起内GSK3βの活性化
田中 融; 大橋 祥世; 高島 明彦; 小林 俊亮
第４２回 日本分子生物学会年会, Dec. 2019, 日本分子生物学会, Not invited - Inhibition of the malignant progression of cancer targeting YB-1 nuclear import
Toru Tanaka; Shinichi Miyairi; Shunsuke Kobayashi
第９２回 日本生化学会大会, Sep. 2019, 日本生化学会, Not invited - Neural activity-dependent translational activation of GSK3β mRNA in neurites and tau phosphorylation
田中 融、大橋 祥世、高島 明彦、小林 俊亮
日本薬学会第139年会, Mar. 2019, 日本薬学会, Not invited - 抗がん剤誘発YB-1核移行を阻害するbis-indole化合物の作用機構
田中 融、笠井 岬、大橋 祥世、小林 俊亮
第41回日本分子生物学会年会, Nov. 2018, 日本分子生物学会, Not invited - Inhibitor of YB-1 nuclear translocation which makes cancer cells more malignant.
Toru Tanaka; Sachiyo Ohashi; Shunsuke Kobayashi
日本薬学会第１３８年会, Mar. 2018, 日本薬学会, Not invited - Activity-dependent translation and hyperphosphorylation of tau mRNA in dendrites
田中融; 小林俊亮; 高島明彦
2017年度 生命科学系学会合同年次大会, Dec. 2017, Not invited - Analyses of YB-NLS-binding proteins and intracellular distribution of YB-1
田中融; 大橋祥世; 齋藤弘明; 和田平; 青山忠; 宮入伸一; 小林俊亮
日本薬学会第137年会, Mar. 2017, Not invited - Four nucleocytoplasmic-shuttling proteins and p53 interact specifically with the YB-NLS and are involved in anticancer reagent-induced nuclear localization of YB-1
田中融; 大橋祥世; 小林俊亮
第39回日本分子生物学会年会, Nov. 2016, Not invited - YB-1 gene expression is kept constant during myocyte differentiation through replacement of different transcription factors and then falls gradually under the control of neural activity
田中融; 大橋祥世; 小林俊亮
第38回日本分子生物学会年会・第88回日本生化学会大会合同大会, Dec. 2015, Not invited - Indirubin derivatives alter DNA binding activity of the transcription factor NF-Y and inhibit MDR1 gene promoter
田中融; 大橋祥世; 小林俊亮
第37回日本分子生物学会年会, Nov. 2014, Not invited - YB-1 acts as a translational activator and controls the number of stress granules.
田中融、大橋祥世、小林俊亮
日本薬学会第134年会, Mar. 2014, Not invited - Roles of YB-1 under arsenite-induced stress: translational activation of HSP70 mRNA and control of the number of stress granules
田中融; 大橋祥世; 小林俊亮
第36回日本分子生物学会年会, Dec. 2013, Not invited - Transcriptional regulation of YB-1 gene and translational regulation of glycometabolic enzymes by YB-1 protein in HepG2 cells
田中融; 大橋祥世; 小林俊亮
日本薬学会第133年会, Mar. 2013, Not invited - Translational regulation of energy metabollic enzymes by YB-1
田中融; 大橋祥世; 小林俊亮
第35回日本分子生物学会年会, Dec. 2012, Not invited - Inhibitory effects of Indirubin derivatives on MDR1 gene promoter
田中融; 大橋祥世; 三輪優貴; 齋藤弘明; 田畑恵市; 鈴木孝; 宮入伸一; 小林俊亮
日本薬学会第132回年会, Mar. 2012, Not invited - Mechanism of YB-1-mediated translational induction of GluR2 mRNA in response to neural activity through nAChR
Toru Tanaka; Sachiyo Ohashi; Masamitsu Moue; Shunsuke Kobayashi
第34回日本分子生物学会年会, Dec. 2011, Not invited
