Prorenin

Peptide vaccine

Diabetic retinopathy

Life sciences, Ophthalmology, Diabetic retinopathy, Prorenin, Peptide vaccine

★Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice
Junya Hanaguri; Harumasa Yokota; Akifumi Kushiyama; Sakura Kushiyama; Masahisa Watanabe; Satoru Yamagami; Taiji Nagaoka
Pharmaceutics, Feb. 2022, Refereed

日大板橋病院における裂孔原性網膜剥離の治療成績
横田 陽匡; 佐伯 忠賜朗; 岩崎 将典; 花栗 潤哉; 秋山 彩香; 大野 皓; 高瀬 公陽; 山本 瑠璃; 山上 聡; 長岡 泰司
眼科臨床紀要, Nov. 2023

両眼に発症した研究用YAGレーザーによる外傷性黄斑円孔の1例
高瀬 公陽; 横田 陽匡; 佐伯 忠賜朗; 岩崎 将典; 花栗 潤哉; 秋山 彩香; 山本 瑠璃; 山上 聡; 長岡 泰司
眼科臨床紀要, Nov. 2023

裂孔原性網膜剥離に対する硝子体術後の黄斑円孔
岩崎 将典; 秋山 彩香; 花崎 浩継; 朝生 浩; 佐伯 忠賜朗; 横田 陽匡; 山上 聡; 長岡 泰司
眼科臨床紀要, Nov. 2023

両眼に発症した研究用YAGレーザーによる外傷性黄斑円孔の1例
高瀬 公陽; 横田 陽匡; 佐伯 忠賜朗; 岩崎 将典; 花栗 潤哉; 秋山 彩香; 山本 瑠璃; 山上 聡; 長岡 泰司
眼科臨床紀要, Apr. 2023

Rapamycinによるブタ摘出網膜動脈血管拡張作用の検討
大野 皓; 横田 陽匡; 櫛山 暁史; 花栗 潤哉; 渡部 昌久; 高瀬 公陽; 山上 聡; 長岡 泰司
日本眼科学会雑誌, Mar. 2023

2型糖尿病マウスにおける新規治療薬の蛍光免疫染色による酸化ストレス評価
花栗 潤哉; 杉山 瑠璃; 櫛山 暁史; 横田 陽匡; 高瀬 公陽; 櫛山 櫻; 山上 聡; 長岡 泰司
日本眼科学会雑誌, Mar. 2023

糖尿病黄斑浮腫に対するアフリベルセプトおよびファリシマブ投与の眼循環への影響
齊間 至成; 横田 陽匡; 櫛山 暁史; 花栗 潤哉; 大野 皓; 高瀬 公陽; 杉山 瑠璃; 村中 公正; 山上 聡; 長岡 泰司
日本眼科学会雑誌, Mar. 2023

2型糖尿病マウスでは、網膜血流調節不全が神経網膜機能障害に先行する(Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice)
花栗 潤哉; 横田 陽匡; 渡部 昌久; 山上 聡; 櫛山 暁史; KouLih; 長岡 泰司
糖尿病合併症, Sep. 2022

Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice
Junya Hanaguri; Harumasa Yokota; Akifumi Kushiyama; Sakura Kushiyama; Masahisa Watanabe; Satoru Yamagami; Taiji Nagaoka
Front Physiol, Feb. 2022, Refereed

Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients
Yasunari Ebuchi; Taiji Nagaoka; Daisuke Fukamachi; Keisuke Kojima; Naotaka Akutsu; Nobuhiro Murata; Yuki Saito; Daisuke Kitano; Harumasa Yokota; Satoru Yamagami; Yasuo Okumura
Sci Rep, Feb. 2022, Refereed

The Effect of Sodium-Dependent Glucose Cotransporter 2 Inhibitor Tofogliflozin on Neurovascular Coupling in the Retina in Type 2 Diabetic Mice
Junya Hanaguri; Harumasa Yokota; Akifumi Kushiyama; Sakura Kushiyama; Masahisa Watanabe; Satoru Yamagami; Taiji Nagaoka
Int J Mol Sci, Jan. 2022, Refereed

Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes
Harumasa Yokota; Hiroki Hayashi; Junya Hanaguri; Satoru Yamagami; Akifumi Kushiyama; Hironori Nakagami; Taiji Nagaoka
PLoS One, Jan. 2022

Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice
Junya Hanaguri; Harumasa Yokota; Masahisa Watanabe; Satoru Yamagami; Akifumi Kushiyama; Lih Kuo; Taiji Nagaoka
Sci Rep, Sep. 2021, Refereed

Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
Harumasa Yokota; Taiji Nagaoka; Hidetaka Noma; Akemi Ofusa; Tomoe Kanemaki; Hiroshi Aso; Hirotsugu Hanazaki; Satoru Yamagami; Masahiko Shimura
Sci Rep, Jul. 2021, Refereed

Development of Stage 4 Macular Hole after Spontaneous Closure in a Patient with Stage 2 Macular Hole and a Lamellar Macular Hole-Associated Epiretinal Proliferation
Masahisa Watanabe; Harumasa Yokota; Hiroshi Aso; Hirotsugu Hanazaki; Junya Hanaguri; Satoru Yamagami; Taiji Nagaoka
Case Rep Ophthalmol, Jul. 2021

The kebab technique uses a bipolar pencil to retrieve a dropped nucleus of the lens via a small incision
Hiroshi Aso; Harumasa Yokota; Hirotsugu Hanazaki; Satoru Yamagami; Taiji Nagaoka
Sci Rep, Apr. 2021, Refereed

Evaluation of ocular blood flow over time in a treated retinal arterial macroaneurysm using laser speckle flowgraphy
Hirotsugu Hanazaki; Harumasa Yokota; Hiroshi Aso; Satoru Yamagami; Taiji Nagaoka
Am J Ophthalmol Case Rep, Feb. 2021

Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes
Masaki Nagaya; Koki Hasegawa; Masahito Watanabe; Kazuaki Nakano; Kazutoshi Okamoto; Takeshi Yamada; Ayuko Uchikura; Kenji Osafune; Harumasa Yokota; Taiji Nagaoka; Hitomi Matsunari; Kazuhiro Umeyama; Eiji Kobayashi; Hiromitsu Nakauchi; Hiroshi Nagashima
BMJ Open Diabetes Res Care, Nov. 2020, Refereed

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy
Junya Hanaguri; Harumasa Yokota; Masahisa Watanabe; Lih Kuo; Satoru Yamagami; Taiji Nagaoka
Sci Rep, Nov. 2020, Refereed

Transforming Growth Factor-β Signaling Cascade Induced by Mechanical Stimulation of Fluid Shear Stress in Cultured Corneal Epithelial Cells
Tsugiaki Utsunomiya; Akihiro Ishibazawa; Taiji Nagaoka; Kazuomi Hanada; Harumasa Yokota; Nobuhito Ishii; Akitoshi Yoshida
Invest Ophthalmol Vis Sci, Nov. 2016, Refereed

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury
Esraa Shosha; Zhimin Xu; Harumasa Yokota; Alan Saul; Modesto Rojas; R William Caldwell; Ruth B Caldwell; S Priya Narayanan
Cell Death Dis, Nov. 2016, Refereed

Characteristics of Retinal Neovascularization in Proliferative Diabetic Retinopathy Imaged by Optical Coherence Tomography Angiography
Akihiro Ishibazawa; Taiji Nagaoka; Harumasa Yokota; Atsushi Takahashi; Tsuneaki Omae; Young-Seok Song; Tatsuhisa Takahashi; Akitoshi Yoshida
Invest Ophthalmol Vis Sci, Nov. 2016, Refereed

SYSTEMIC RISK FACTORS IN BILATERAL PROLIFERATIVE DIABETIC RETINOPATHY REQUIRING VITRECTOMY
Young-Seok Song; Taiji Nagaoka; Tsuneaki Omae; Harumasa Yokota; Atsushi Takahashi; Akitoshi Yoshida
Retina, Jul. 2016, Refereed

Radial Peripapillary Capillary Network Visualized Using Wide-Field Montage Optical Coherence Tomography Angiography
Tomoko Mase; Akihiro Ishibazawa; Taiji Nagaoka; Harumasa Yokota; Akitoshi Yoshida
Invest Ophthalmol Vis Sci, Jul. 2016, Refereed

Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury
Akito Shimouchi; Harumasa Yokota; Shinji Ono; Chiemi Matsumoto; Toshihiro Tamai; Hiroko Takumi; Subbadra P. Narayanan; Shoji Kimura; Hiroya Kobayashi; Ruth B. Caldwell; Taiji Nagaoka; Akitoshi Yoshida
JAPANESE JOURNAL OF OPHTHALMOLOGY, Jan. 2016, Refereed, Not invited

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma
Y Ha; H Liu; Z Xu; H Yokota; S P Narayanan; T Lemtalsi; S B Smith; R W Caldwell; R B Caldwell; W Zhang
Cell Death Dis, Oct. 2015, Refereed

Imaging of the Corneal Subbasal Whorl-like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients With Diabetes
Tsugiaki Utsunomiya; Taiji Nagaoka; Kazuomi Hanada; Tsuneaki Omae; Harumasa Yokota; Atsuko Abiko; Masakazu Haneda; Akitoshi Yoshida
Invest Ophthalmol Vis Sci, Aug. 2015, Refereed

Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study
Akihiro Ishibazawa; Taiji Nagaoka; Atsushi Takahashi; Tsuneaki Omae; Tomofumi Tani; Kenji Sogawa; Harumasa Yokota; Akitoshi Yoshida
Am J Ophthalmol, Jul. 2015, Refereed

Role of neuronal nitric oxide synthase in regulating retinal blood flow during flicker-induced hyperemia in cats
Takafumi Yoshioka; Taiji Nagaoka; Youngseok Song; Harumasa Yokota; Tomofumi Tani; Akitoshi Yoshida
Invest Ophthalmol Vis Sci, May 2015, Refereed

Temporal posttraumatic limited ocular movement with suspected trapdoor fracture
Young-Seok Song; Harumasa Yokota; Haruna Ito; Akitoshi Yoshida
Clin Ophthalmol, Aug. 2014, Refereed

Low shear stress up-regulation of proinflammatory gene expression in human retinal microvascular endothelial cells
Akihiro Ishibazawa; Taiji Nagaoka; Harumasa Yokota; Shinji Ono; Akitoshi Yoshida
Exp Eye Res, Nov. 2013, Refereed

Correlation between plasma pentosidine concentrations and retinal hemodynamics in patients with type 2 diabetes
Eiichi Sato; Taiji Nagaoka; Harumasa Yokota; Atsushi Takahashi; Akitoshi Yoshida
Am J Ophthalmol, Mar. 2012, Refereed

Neuroprotection from Retinal Ischemia/Reperfusion Injury by NOX2 NADPH Oxidase Deletion
Harumasa Yokota; Subhadra P. Narayanan; Wenbo Zhang; Hua Liu; Modesto Rojas; Zhimin Xu; Tahira Lemtalsi; Taiji Nagaoka; Akitoshi Yoshida; Steven E. Brooks; Robert W. Caldwell; Ruth B. Caldwell
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Oct. 2011, Refereed, Not invited

Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes
Harumasa Yokota; Taiji Nagaoka; Tomofumi Tani; Atsushi Takahashi; Eiichi Sato; Yuji Kato; Akitoshi Yoshida
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, Sep. 2011, Refereed, Not invited

Hyperoxia Therapy of Pre-Proliferative Ischemic Retinopathy in a Mouse Model
Wenbo Zhang; Harumasa Yokota; Zhimin Xu; Subhadra P. Narayanan; Lauren Yancey; Akitoshi Yoshida; Dennis M. Marcus; Robert W. Caldwell; Ruth B. Caldwell; Steven E. Brooks
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Aug. 2011, Refereed, Not invited

Macular hole formation in fellow eyes with a perifoveal posterior vitreous detachment of patients with a unilateral macular hole
Atsushi Takahashi; Akitoshi Yoshida; Taiji Nagaoka; Hiroyuki Kagokawa; Yuji Kato; Akira Takamiya; Eiichi Sato; Harumasa Yokota; Satoshi Ishiko; Hiroyuki Hirokawa
Am J Ophthalmol, Jun. 2011, Refereed

Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry study
Taiji Nagaoka; Eiichi Sato; Atsushi Takahashi; Harumasa Yokota; Kenji Sogawa; Akitoshi Yoshida
Invest Ophthalmol Vis Sci, Dec. 2010, Refereed

Effect of aging on retinal circulation in normotensive healthy subjects
Taiji Nagaoka; Eiichi Sato; Atsushi Takahashi; Kenji Sogawa; Harumasa Yokota; Akitoshi Yoshida
Exp Eye Res, Dec. 2009, Refereed

Prorenin levels in retinopathy of prematurity
HARUMASA Yokota; TAIJI Nagaoka; FUMIHIKO Mori; TAIICHI Hikichi; HIROMICHI Hosokawa; HIROSHI Tanaka; YUICHI Ishida; FUMIAKI Suzuki; AKITOSHI Yoshida
American Journal of Ophthalmology, 2007, Refereed, Not invited
Lead

Serum prorenin levels and diabetic retinopathy in type 2 diabetes: new method to measure serum level of prorenin using antibody activating direct kinetic assay
H Yokota; F Mori; K Kai; T Nagaoka; N Izumi; A Takahashi; T Hikichi; A Yoshida; F Suzuki; Y Ishida
BRITISH JOURNAL OF OPHTHALMOLOGY, Jul. 2005, Refereed, Not invited

Pulsatile ocular blood flow: changes associated with scleral buckling
HARUMASA Yokota; FUMIHIKO Mori; TAIJIi Nagaoka; RYOICHI Sugawara; AKITOSHI Yoshida.
Japan Journal of Ophthalmology, 2005, Not refereed, Not invited
Lead

Pulsatile ocular blood flow is unaffected in type 2 diabetes mellitus
Fumihiko Mori; Harumasa Yokota; Taiji Nagaoka; Suguru Konno; Hiroyuki Kagokawa; Taiichi Hikichi; Akitoshi Yoshida
Jpn J Ophthalmol, Nov. 2003, Refereed

Serum prorenin levels are not associated with ocular diseases in non-diabetic subjects
Harumasa Yokota; Taiji Nagaoka; Eiichi Sato; Atsushi Takahashi; Akito Shimouchi; Akitoshi Yoshida
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, Mar. 2015, Not refereed, Not invited

Role of prorenin in the pathogenesis of retinal neovascularization
HARUMASA Yokota; AKIRA Takamiya; TAIJI Nagaoka; TAIICHI Hikichi; YUICHI Ishida; FUMIAKI Suzuki; AKITOSHI Yoshida
Hokkaido Igaku Zasshi, 2008, Refereed, Not invited
Lead

角膜混濁眼の硝子体手術に用いる人工角膜を用いた手術について教えてください
Single work
金原出版, Not refereed

中心窩を含む裂孔原性網膜剥離に対する硝子体手術後の眼循環動態
2019, Not invited

プロレニンを標的とした治療ワクチンの２型糖尿病モデルでの基礎的検討
日本眼科学会総会, Apr. 2018, Not invited

Elucidation of regulatory mechanism of neurovascular coupling interaction in retinal circulation and clinical application for early diagnosis of diabetic retinopathy
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2013 - 31 Mar. 2017
NAGAOKA Taiji

糖尿病網膜症の発症予防のためのワクチン治療の開発

糖転移ヘスペリジンによる糖尿病網膜症新規治療薬の開発

プロレニンを標的とした糖尿病網膜症の新規治療薬の開発