Yamashita Hiroharu

Department of MedicineProfessor

Degree

  • 博士(医学), The University of Tokyo, May 2009

Field Of Study

  • Life sciences, Digestive surgery

Career

  • Jan. 2021 - Present
    Department of Digestive Surgery, Nihon University School of Medicine
  • Apr. 2013 - Dec. 2020
    Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo

Educational Background

  • The University of Tokyo, 医学部, 医学科
Research activity information

Paper

  • ★Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma
    Hiroharu Yamashita; Yasuyuki Seto; Takeshi Sano; Hiroyasu Makuuchi; Nobutoshi Ando; Mitsuru Sasako; Japanese Gastric Cancer Association and the Japan Esophageal Society
    Gastric Cancer, Mar. 2017, Refereed, Not invited
    Lead
  • ★Optimal extent of lymph node dissection for Siewert type II esophagogastric junction carcinoma
    Hiroharu Yamashita; Hitoshi Katai; Shinji Morita; Makoto Saka; Hirokazu Taniguchi; Takeo Fukagawa
    Ann Surg, Aug. 2011, Refereed, Not invited
    Lead
  • ★Tissue factor expression is a clinical indicator of lymphatic metastasis and poor prognosis in gastric cancer with intestinal phenotype
    Hiroharu Yamashita; Joji Kitayama; Makoto Ishikawa; Hirokazu Nagawa
    J Surg Oncol, Mar. 2007, Refereed, Not invited
    Lead
  • Alterations in Intratumoral Immune Response before and during Early-On Nivolumab Treatment for Unresectable Advanced or Recurrent Gastric Cancer.
    Yasuyoshi Sato; Hiroharu Yamashita; Yukari Kobayashi; Koji Nagaoka; Tetsuro Hisayoshi; Takuya Kawahara; Akihiro Kuroda; Noriyuki Saito; Ryohei Iwata; Yasuhiro Okumura; Koichi Yagi; Susumu Aiko; Sachiyo Nomura; Kazuhiro Kakimi; Yasuyuki Seto
    International journal of molecular sciences, Nov. 2023
  • PD-L1 and HLA-class I expression status and their therapeutic implication in oesophageal small-cell carcinoma.
    Satoshi Yamashita; Hiroyuki Abe; Hiroharu Yamashita; Koichi Yagi; Yasuyuki Seto; Tetsuo Ushiku
    Histopathology, Apr. 2023
  • Anomalous vascular anatomy of the left gastric artery in oesophagectomy
    Hagiwara K; Yamashita H.
    ANZ Journal of Surgery, May 2022, Refereed, Not invited
    Corresponding
  • Universal encoding of pan-cancer histology by deep texture representations.
    Daisuke Komura; Akihiro Kawabe; Keisuke Fukuta; Kyohei Sano; Toshikazu Umezaki; Hirotomo Koda; Ryohei Suzuki; Ken Tominaga; Mieko Ochi; Hiroki Konishi; Fumiya Masakado; Noriyuki Saito; Yasuyoshi Sato; Takumi Onoyama; Shu Nishida; Genta Furuya; Hiroto Katoh; Hiroharu Yamashita; Kazuhiro Kakimi; Yasuyuki Seto; Tetsuo Ushiku; Masashi Fukayama; Shumpei Ishikawa
    Cell reports, Mar. 2022
  • 胃癌におけるニボルマブ治療前後の腫瘍内免疫応答の解析
    佐藤 靖祥; 山下 裕玄; 小林 由香利; 長岡 孝治; 高橋 俊二; 瀬戸 泰之; 垣見 和宏
    日本癌学会総会記事, Sep. 2021
  • Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation
    Chun-Dong Zhang; Hideyuki Takeshima; Shigeki Sekine; Satoshi Yamashita; Yu-Yu Liu; Naoko Hattori; Hiroyuki Abe; Hiroharu Yamashita; Masahide Fukuda; Yu Imamura; Tetsuo Ushiku; Hitoshi Katai; Hiroshi Makino; Masayuki Watanabe; Yasuyuki Seto; Toshikazu Ushijima
    Gastric Cancer, Sep. 2021, Refereed, Not invited
  • Human Leukocyte Antigen Class I Deficiency in Gastric Carcinoma: An Adaptive Immune Evasion Strategy Most Common in Microsatellite Instable Tumors
    Akiko Iwasaki; Aya Shinozaki-Ushiku; Akiko Kunita; Sho Yamazawa; Yasuyoshi Sato; Hiroharu Yamashita; Masashi Fukayama; Yasuyuki Seto; Tetsuo Ushiku
    Am J Surg Pathol, Sep. 2021, Refereed, Not invited
  • Identifying multiple swollen lymph nodes on preoperative computed tomography is associated with poor prognosis along with pathological extensive nodal metastasis in locally advanced gastric cancer
    Motonari Ri; Hiroharu Yamashita; Wataru Gonoi; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Eur J Surg Oncol, Aug. 2021, Refereed, Not invited
  • Taxane-based versus platinum-based chemotherapy in early recurrent gastric cancer after radical surgery with S-1 adjuvant chemotherapy: A multi-institutional retrospective analysis
    Sakae Nagaoka; Hiroharu Yamashita; Yasuyuki Seto; Muneharu Fujisaki; Norio Mitsumori; Yoko Oshima; Satoshi Yajima; Yoshinori Kikuchi; Koji Otsuka; Masahiko Murakami; Shohei Fujita; Nobue Futawatari; Hideaki Shimada
    Asia Pac J Clin Oncol, Jul. 2021, Refereed, Not invited
  • Prognosis of hemodialysis patients undergoing surgery for gastric cancer: Results of a multicenter retrospective study
    Kotaro Sugawara; Hiroharu Yamashita; Satoshi Yajima; Yoko Oshima; Norio Mitsumori; Muneharu Fujisaki; Kimiyasu Yamazaki; Koji Otsuka; Nobue Futawatari; Ryohei Watanabe; Hitoshi Satodate; Yutaro Yoshimoto; Sakae Nagaoka; Jo Tokuyama; Shin Sasaki; Yasuyuki Seto; Hideaki Shimada
    Surgery, Jul. 2021, Refereed, Not invited
    Corresponding
  • Geriatric Nutrition Index Influences Survival Outcomes in Gastric Carcinoma Patients Undergoing Radical Surgery
    Kotaro Sugawara; Hiroharu Yamashita; Masayuki Urabe; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    J Parenter Enteral Nutr, Jul. 2021, Refereed, Not invited
  • Salvage treatment after definitive chemoradiotherapy for esophageal squamous cell carcinoma
    Koichi Yagi; Tetsuro Toriumi; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
    Ann Gastroenterol Surg, May 2021, Refereed, Not invited
  • Trunk fat volume can be a predictor of postoperative complications after gastrectomy: a retrospective cohort study
    Shinichiro Shiomi; Tetsuro Toriumi; Koichi Yagi; Raito Asaoka; Yasuhiro Okumura; Kotaro Wakamatsu; Susumu Aikou; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    BMC Surg, Apr. 2021, Refereed, Not invited
  • Comparison of short-term outcomes between transthoracic and robot-assisted transmediastinal radical surgery for esophageal cancer: a prospective study
    Shuntaro Yoshimura; Kazuhiko Mori; Motonari Ri; Susumu Aikou; Koichi Yagi; Yukinori Yamagata; Masato Nishida; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    BMC Cancer, Mar. 2021, Refereed, Not invited
  • Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis
    Pipit Burasakarn; Ryota Higuchi; Souya Nunobe; Shingo Kanaji; Hidetoshi Eguchi; Ken-Ichi Okada; Tsutomu Fujii; Yuichi Nagakawa; Kengo Kanetaka; Hiroharu Yamashita; Suguru Yamada; Shinji Kuroda; Toru Aoyama; Takahiro Akahori; Kenji Nakagawa; Masakazu Yamamoto; Hiroki Yamaue; Masayuki Sho; Yasuhiro Kodera; Japan Duodenal Cancer Guideline Committee
    Int J Clin Oncol, Mar. 2021, Refereed, Not invited
  • Programmed cell death protein 1/programmed death ligand 1 but not HER2 is a potential therapeutic target in gastric neuroendocrine carcinoma
    Satoshi Yamashita; Hiroyuki Abe; Akiko Kunita; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku
    Histopathology, Feb. 2021, Refereed, Not invited
  • A phase I study of intraperitoneal paclitaxel combined with gemcitabine plus nab-paclitaxel for pancreatic cancer with peritoneal metastasis
    Naminatsu Takahara; Yousuke Nakai; Hironori Ishigami; Kei Saito; Tatsuya Sato; Ryunosuke Hakuta; Kazunaga Ishigaki; Tomotaka Saito; Tsuyoshi Hamada; Suguru Mizuno; Hirofumi Kogure; Hiroharu Yamashita; Hiroyuki Isayama; Yasuyuki Seto; Kazuhiko Koike
    Invest New Drugs, Feb. 2021, Refereed, Not invited
  • The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey
    Shinichi Kinami; Masaki Aizawa; Hiroharu Yamashita; Koshi Kumagai; Satoshi Kamiya; Makoto Toda; Takaomi Takahata; Muneharu Fujisaki; Hiroshi Miyamoto; Hiroshi Kusanagi; Kenta Kobayashi; Marie Washio; Kei Hosoda; Takeo Kosaka
    Gastric Cancer, Jan. 2021, Refereed, Not invited
  • Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation
    Munetoshi Hinata; Akiko Kunita; Hiroyuki Abe; Yasuyuki Morishita; Kei Sakuma; Hiroharu Yamashita; Yasuyuki Seto; Tetsuo Ushiku; Masashi Fukayama
    Microorganisms, Nov. 2020, Refereed, Not invited
  • Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor-infiltrating cells
    Yasuyoshi Sato; Ikuo Wada; Kosuke Odaira; Akihiro Hosoi; Yukari Kobayashi; Koji Nagaoka; Takahiro Karasaki; Hirokazu Matsushita; Koichi Yagi; Hiroharu Yamashita; Masashi Fujita; Shuichi Watanabe; Takashi Kamatani; Fuyuki Miya; Junichi Mineno; Hidewaki Nakagawa; Tatsuhiko Tsunoda; Shunji Takahashi; Yasuyuki Seto; Kazuhiro Kakimi
    Clin Transl Immunology, Oct. 2020, Refereed, Not invited
  • Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo-carmine dye contrast imaging
    Sayaka Nagao; Yosuke Tsuji; Yoshiki Sakaguchi; Yu Takahashi; Chihiro Minatsuki; Keiko Niimi; Hiroharu Yamashita; Nobutake Yamamichi; Yasuyuki Seto; Tomohiro Tada; Kazuhiko Koike
    Gastrointest Endosc, Oct. 2020, Refereed, Not invited
  • Age-dependent survival impact of body mass index in patients with oesophageal squamous cell carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Eur J Surg Oncol, Oct. 2020, Refereed, Not invited
  • Poor nutritional status and sarcopenia influences survival outcomes in gastric carcinoma patients undergoing radical surgery
    Kotaro Sugawara; Hiroharu Yamashita; Masayuki Urabe; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Eur J Surg Oncol, Oct. 2020, Refereed, Not invited
  • One-by-One Comparison of Lymph Nodes Between 18F-FDG Uptake and Pathological Diagnosis in Esophageal Cancer
    Shuntaro Yoshimura; Miwako Takahashi; Susumu Aikou; Yasuhiro Okumura; Keiichi Jinbo; Haruna Onoyama; Masayuki Urabe; Koichiro Kawasaki; Koichi Yagi; Masato Nishida; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Keitaro Koyama; Toshimitsu Momose; Hiroyuki Abe; Tetsuo Ushiku; Masashi Fukayama; Yasuyuki Seto
    Clin Nucl Med, Oct. 2020, Refereed, Not invited
  • Preoperative restrictive pulmonary dysfunction influences the survival after gastrectomy for elderly patients with gastric carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Sho Yajima; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Surg Today, Sep. 2020, Refereed, Not invited
  • What are the important prognostic factors in gastric cancer with positive duodenal margins? A multi-institutional analysis
    Shohei Fujita; Yoko Oshima; Satoshi Yajima; Yoshinori Kikuchi; Sakae Nagaoka; Hiroharu Yamashita; Yasuyuki Seto; Muneharu Fujisaki; Norio Mitsumori; Koji Otsuka; Masahiko Murakami; Hidejiro Urakami; Yoh Isobe; Yutaro Yoshimoto; Hitoshi Satodate; Yoshihisa Saida; Hideaki Shimada
    Surg Today, Aug. 2020, Refereed, Not invited
  • Preoperative Exercise Habits are Associated with Post-gastrectomy Complications
    Tetsuro Toriumi; Hiroharu Yamashita; Koichiro Kawasaki; Yasuhiro Okumura; Kotaro Wakamatsu; Koichi Yagi; Susumu Aikou; Sachiyo Nomura; Yasuyuki Seto
    World J Surg, Aug. 2020, Refereed, Not invited
  • Associations of Systemic Inflammation and Sarcopenia With Survival of Esophageal Carcinoma Patients
    Kotaro Sugawara; Koichi Yagi; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Susumu Aikou; Hiroharu Yamashita; Yasuyuki Seto
    Ann Thorac Surg, Aug. 2020, Refereed, Not invited
  • Optimal Definition of Nodal Skip Metastasis in Patients With Esophageal Squamous Cell Carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
    Ann Thorac Surg, Aug. 2020, Refereed, Not invited
  • Preoperative Low Vital Capacity Influences Survival After Esophagectomy for Patients with Esophageal Carcinoma
    Kotaro Sugawara; Kazuhiko Mori; Yasuhiro Okumura; Koichi Yagi; Susumu Aikou; Yukari Uemura; Hiroharu Yamashita; Yasuyuki Seto
    World J Surg, Jul. 2020, Refereed, Not invited
  • Pre- and post-operative low prognostic nutritional index influences survival in older patients with gastric carcinoma
    Kotaro Sugawara; Susumu Aikou; Sho Yajima; Yukari Uemura; Yasuhiro Okumura; Masato Nishida; Koichi Yagi; Hiroharu Yamashita; Yasuyuki Seto
    J Geriatr Oncol, Jul. 2020, Refereed, Not invited
  • Relationships among body composition, muscle strength, and sarcopenia in esophageal squamous cell carcinoma patients
    Kotaro Sugawara; Hiroharu Yamashita; Yasuhiro Okumura; Koichi Yagi; Shuntaro Yoshimura; Koichiro Kawasaki; Asami Tanabe; Susumu Aikou; Yasuyuki Seto
    Support Care Cancer, Jun. 2020, Refereed, Not invited
  • Long-term outcomes of multimodal therapy combining definitive chemoradiotherapy and salvage surgery for T4 esophageal squamous cell carcinoma
    Kotaro Sugawara; Koichi Yagi; Yasuhiro Okumura; Masato Nishida; Susumu Aikou; Hiroharu Yamashita; Hideomi Yamashita; Yasuyuki Seto
    Int J Clin Oncol, Apr. 2020, Refereed, Not invited
  • Long-term health-related quality of life following robot-assisted radical transmediastinal esophagectomy
    Kotaro Sugawara; Shuntaro Yoshimura; Koichi Yagi; Masato Nishida; Susumu Aikou; Yukinori Yamagata; Kazuhiko Mori; Hiroharu Yamashita; Yasuyuki Seto
    Surg Endosc, Apr. 2020, Refereed, Not invited
  • Perioperative fluid dynamics evaluated by bioelectrical impedance analysis predict infectious surgical complications after esophagectomy
    Shuichiro Oya; Hiroharu Yamashita; Ryohei Iwata; Koichiro Kawasaki; Asami Tanabe; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    BMC Surg, Dec. 2019, Refereed, Not invited
  • Prognostic significance of neutrophil-to-lymphocyte ratio in solid tumors: a note on methodological concerns
    Masayuki Urabe; Hiroharu Yamashita; Yasuyuki Seto
    Biomark Med, Dec. 2019, Refereed, Invited
  • Gastric cancer surgery: historical background and perspective in Western countries versus Japan
    Chun-Dong Zhang; Hiroharu Yamashita; Yasuyuki Seto
    Ann Transl Med, Nov. 2019, Refereed, Not invited
    Corresponding
  • Giant Brunner's gland adenoma of the duodenum manifested by melena
    Masayuki Urabe; Hiroharu Yamashita; Masato Nishida; Yasuyuki Seto
    ANZ J Surg, Sep. 2019, Refereed, Not invited
  • Optimal postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by surgery for esophageal carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
    J Thorac Dis, Sep. 2019, Refereed, Invited
  • Gastric cancer with solitary liver metastasis accompanied by cyst formation
    Masayuki Urabe; Hiroharu Yamashita; Nobuhisa Akamatsu; Yasuyuki Seto
    ANZ J Surg, Jun. 2019, Refereed, Not invited
  • Preoperative lymph node status on computed tomography influences the survival of pT1b, T2 and T3 esophageal squamous cell carcinoma
    Kotaro Sugawara; Hiroharu Yamashita; Yukari Uemura; Koichi Yagi; Masato Nishida; Susumu Aikou; Sachiyo Nomura; Yasuyuki Seto
    Surg Today, May 2019, Refereed, Not invited
  • Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy
    Kotaro Sugawara; Kazuhiko Mori; Koichi Yagi; Susumu Aikou; Yukari Uemura; Hiroharu Yamashita; Yasuyuki Seto
    Dis Esophagus, Apr. 2019, Refereed, Not invited
  • Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein-Barr Virus-associated gastric carcinoma
    Atsuhito Nakayama; Hiroyuki Abe; Akiko Kunita; Ruri Saito; Teru Kanda; Hiroharu Yamashita; Yasuyuki Seto; Shumpei Ishikawa; Masashi Fukayama
    Plos One, Jan. 2019, Refereed, Not invited
  • Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy
    Kazuyoshi Ohtomo; Reiko Arita; Rika Shirakawa; Tomohiko Usui; Hiroharu Yamashita; Yasuyuki Seto; Satoru Yamagami; TS-1 Multicenter Study Group
    Transl Vis Sci Technol, Dec. 2018, Refereed, Not invited
  • Pregnancy, delivery, and breastfeeding after total gastrectomy for gastric cancer: a case report
    Kazuya Higashizono; Sachiyo Nomura; Koichi Yagi; Susumu Aikou; Masato Nishida; Hiroharu Yamashita; Yasuyuki Seto
    World J Surg Oncol, Nov. 2018, Refereed, Not invited
  • Reply to "Nodal skip metastasis may undermine the predictive power of topographic pN classification in esophageal squamous cell carcinoma"
    Kotaro Sugawara; Hiroharu Yamashita; Yasuyuki Seto
    Surgery, Nov. 2018, Refereed, Not invited
  • Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort
    Masayuki Urabe; Tetsuo Ushiku; Aya Shinozaki-Ushiku; Akiko Iwasaki; Sho Yamazawa; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    Cancer Med, Oct. 2018, Refereed, Not invited
  • Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance
    Kosuke Sakitani; Toshihiro Nishizawa; Masahide Arita; Shuntaro Yoshida; Yosuke Kataoka; Daisuke Ohki; Hiroharu Yamashita; Yoshihiro Isomura; Akira Toyoshima; Hidenobu Watanabe; Toshiro Iizuka; Yutaka Saito; Junko Fujisaki; Naohisa Yahagi; Kazuhiko Koike; Osamu Toyoshima
    Helicobacter, Aug. 2018, Refereed, Not invited
  • Reevaluation of laparoscopic versus open distal gastrectomy for early gastric cancer in Asia: A meta-analysis of randomized controlled trials
    Chun-Dong Zhang; Hiroharu Yamashita; Shun Zhang; Yasuyuki Seto
    Int J Surg, Aug. 2018, Refereed, Not invited
  • Presentation of oropharyngeal dysphagia and rehabilitative intervention following esophagectomy: a systematic review
    A Kaneoka; S Yang; H Inokuchi; R Ueha; H Yamashita; T Nito; Y Seto; N Haga
    Dis Esophagus, Aug. 2018, Refereed, Not invited
  • Mediastinoscopic view of the bronchial arteries in a series of surgical cases evaluated with three-dimensional computed tomography
    Kazuhiko Mori; Kenji Ino; Shuntaro Yoshimura; Susumu Aikou; Koichi Yagi; Masato Nishida; Takashi Mitsui; Yasuhiro Okumura; Yukinori Yamagata; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    Esophagus, Jul. 2018, Refereed, Not invited
  • Quality of life after robot-assisted transmediastinal radical surgery for esophageal cancer
    Shuntaro Yoshimura; Kazuhiko Mori; Yukinori Yamagata; Susumu Aikou; Koichi Yagi; Masato Nishida; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    Surg Endosc, May 2018, Refereed, Not invited
  • Helicobacter pylori infection in subjects negative for high titer serum antibody
    Osamu Toyoshima; Toshihiro Nishizawa; Masahide Arita; Yosuke Kataoka; Kosuke Sakitani; Shuntaro Yoshida; Hiroharu Yamashita; Keisuke Hata; Hidenobu Watanabe; Hidekazu Suzuki
    World J Gastroenterol, Apr. 2018, Refereed, Not invited
  • CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8 +/Foxp3 + T cells
    Hiroyuki Abe; Ruri Saito; Takashi Ichimura; Akiko Iwasaki; Sho Yamazawa; Aya Shinozaki-Ushiku; Teppei Morikawa; Tetsuo Ushiku; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    Virchows Arch, Apr. 2018, Refereed, Not invited
  • Non-linear association between long-term outcome and preoperative neutrophil-to-lymphocyte ratio in patients undergoing curative resection for gastric cancer: a retrospective analysis of 1335 cases in a tetrachotomous manner
    Masayuki Urabe; Hiroharu Yamashita; Yukari Uemura; Asami Tanabe; Koichi Yagi; Susumu Aikou; Yasuyuki Seto
    Jpn J Clin Oncol, Apr. 2018, Refereed, Not invited
  • Non-exposed endoscopic wall-inversion surgery for gastrointestinal stromal tumor
    Takashi Mitsui; Hiroharu Yamashita; Susumu Aikou; Keiko Niimi; Mitsuhiro Fujishiro; Yasuyuki Seto
    Transl Gastroenterol Hepatol, Mar. 2018, Refereed, Invited
    Corresponding
  • Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)
    Rihito Kanamaru; Hideyuki Ohzawa; Hideyo Miyato; Shiro Matsumoto; Hidenori Haruta; Kentaro Kurashina; Shin Saito; Yoshinori Hosoya; Hironori Yamaguchi; Hiroharu Yamashita; Yasuyuki Seto; Alan Kawarai Lefor; Naohiro Sata; Joji Kitayama
    Sci Rep, Jan. 2018, Refereed, Not invited
  • Comparison of Prognostic Abilities Among Preoperative Laboratory Data Indices in Patients with Resectable Gastric and Esophagogastric Junction Adenocarcinoma
    Masayuki Urabe; Hiroharu Yamashita; Toshiaki Watanabe; Yasuyuki Seto
    World J Surg, Jan. 2018, Refereed, Not invited
  • Efficacy of trastuzumab beyond progression as second-line chemotherapy for HER2-positive advanced gastric cancer
    Yasuyoshi Sato; Hiroharu Yamashita; Koichi Yagi; Susumu Aikou; Masato Nishida; Yoshiharu Takenaka; Sachiyo Nomura; Yasuyuki Seto
    Gastrointestinal Cancer: Targets and Therapy, Dec. 2017
  • Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis
    Osamu Toyoshima; Chizu Tanikawa; Ryuta Yamamoto; Hidenobu Watanabe; Hiroharu Yamashita; Kosuke Sakitani; Shuntaro Yoshida; Michiaki Kubo; Keitaro Matsuo; Hidemi Ito; Kazuhiko Koike; Yasuyuki Seto; Koichi Matsuda
    Oncotarget, Dec. 2017, Refereed, Not invited
  • Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer
    Masayuki Urabe; Hiroharu Yamashita; Yasuyuki Seto
    Ann Surg, Dec. 2017, Refereed, Not invited
  • Results of a nationwide questionnaire-based survey on nutrition management following gastric cancer resection in Japan
    Nobuyuki Shimizu; Fumihiko Hatao; Kazuhiko Fukatsu; Susumu Aikou; Yukinori Yamagata; Kazuhiko Mori; Hiroharu Yamashita; Sachiyo Nomura; Yasuyuki Seto
    Surg Today, Dec. 2017, Refereed, Not invited
  • Reply to: LODDS or negative to positive lymph nodes ratio?
    Hiroharu Yamashita; Jingyu Deng; Han Liang; Yasuyuki Seto
    Surgery, Nov. 2017, Refereed, Not invited
    Lead
  • Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma
    Sho Yamazawa; Tetsuo Ushiku; Aya Shinozaki-Ushiku; Akimasa Hayashi; Akiko Iwasaki; Hiroyuki Abe; Amane Tagashira; Hiroharu Yamashita; Yasuyuki Seto; Hiroyuki Aburatani; Masashi Fukayama
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Jul. 2017, Refereed, Not invited
  • Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication
    Osamu Toyoshima; Yutaka Yamaji; Shuntaro Yoshida; Shuhei Matsumoto; Hiroharu Yamashita; Takamitsu Kanazawa; Keisuke Hata
    Surg Endosc, May 2017, Refereed, Not invited
  • How should we define the no. 3b lesser curvature lymph node?
    Hiroharu Yamashita; Koichi Yagi; Yasuyuki Seto
    Gastric Cancer, May 2017, Refereed, Not invited
    Lead
  • Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor
    Keiko Niimi; Rei Ishibashi; Takashi Mitsui; Susumu Aikou; Shinya Kodashima; Hiroharu Yamashita; Nobutake Yamamichi; Yoshihiro Hirata; Mitsuhiro Fujishiro; Yasuyuki Seto; Kazuhiko Koike
    Ann Transl Med, Apr. 2017, Refereed, Not invited
  • Analysis of glycero-lysophospholipids in gastric cancerous ascites
    Shigenobu Emoto; Makoto Kurano; Kuniyuki Kano; Keisuke Matsusaki; Hiroharu Yamashita; Masako Nishikawa; Koji Igarashi; Hitoshi Ikeda; Junken Aoki; Joji Kitayama; Yutaka Yatomi
    J Lipid Res, Apr. 2017, Refereed, Not invited
  • Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1(+) immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications
    Ruri Saito; Hiroyuki Abe; Akiko Kunita; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    MODERN PATHOLOGY, Mar. 2017, Refereed, Not invited
  • Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings
    Hironori Ishigami; Hironori Yamaguchi; Hiroharu Yamashita; Masahiro Asakage; Joji Kitayama
    Gastric Cancer, Mar. 2017, Refereed, Not invited
  • Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients
    Jingyu Deng; Hiroharu Yamashita; Yasuyuki Seto; Han Liang
    Ann Surg Oncol, Mar. 2017, Refereed, Not invited
  • Updated evidence on endoscopic resection of early gastric cancer from Japan
    Mitsuhiro Fujishiro; Shuntaro Yoshida; Rie Matsuda; Akiko Narita; Hiroharu Yamashita; Yasuyuki Seto
    Gastric Cancer, Mar. 2017, Refereed, Not invited
  • Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection
    Toshihiro Nishizawa; Hidekazu Suzuki; Kosuke Sakitani; Hiroharu Yamashita; Shuntaro Yoshida; Keisuke Hata; Takamitsu Kanazawa; Naoto Fujiwara; Takanori Kanai; Naohisa Yahagi; Osamu Toyoshima
    United European Gastroenterol J, Feb. 2017, Refereed, Not invited
  • Early endoscopic management for early bowel obstruction after gastrectomy: a case report
    K Higashizono; S Aikou; K Yagi; K Mori; H Yamashita; S Nomura; Y Seto
    Surg Case Rep, Dec. 2016, Refereed, Not invited
  • Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis.
    Takashi Ichimura; Hiroyuki Abe; Teppei Morikawa; Hiroharu Yamashita; Shumpei Ishikawa; Tetsuo Ushiku; Yasuyuki Seto; Masashi Fukayama
    Human pathology, Oct. 2016
  • In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.
    Hiroyuki Abe; Teppei Morikawa; Ruri Saito; Hiroharu Yamashita; Yasuyuki Seto; Masashi Fukayama
    Virchows Archiv : an international journal of pathology, May 2016
  • HER2 Expression in Carcinomas of the True Cardia (Siewert Type II Esophagogastric Junction Carcinoma)
    Hitoshi Katai; Michihiro Ishida; Hiroharu Yamashita; Masaki Ohashi; Shinji Morita; Hiroshi Katayama; Takeo Fukagawa; Ryoji Kushima
    WORLD JOURNAL OF SURGERY, Feb. 2014

MISC

  • Survivals in a Phase 1 trial of autologous tumor lysate-pulsed DC vaccination after resection of esophageal cancer
    Yasuyoshi Sato; Hirokazu Matsushita; Kotaro Sugawara; Hiroharu Yamashita; Kazuhiko Mori; Kazuhiro Kakimi; Yasuyuki Seto
    ANNALS OF ONCOLOGY, Oct. 2017, Not refereed, Not invited

Lectures, oral presentations, etc.

  • Pylorus preserving gastrectomy: historical background and our perspectives
    Hiroharu Yamashita; Yasuyuki Seto
    China-Japan Webinar: Laparoscopic Function-Preserving Gastrectomy For Middle or Upper Third Gastric Cancer, Jul. 2020, Invited
  • Laparoscopic distal gastrectomy with D2 lymph node dissection
    Hiroharu Yamashita
    14th Surgical Society Of Northern Greece Congress, Oct. 2019, Invited
  • D2 lymph node dissection in gastric cancer -the Japanese perspective-
    Hiroharu Yamashita
    Shiraz International Surgical Oncology Congress, Nov. 2018, Invited
  • Optimal extent of surgical resection for adenocarcinoma of the esophagogastric junction
    Hiroharu Yamashita; Yasuyuki Seto
    Shiraz International Surgical Oncology Congress, Nov. 2018, Invited
  • 食道胃接合部癌に対するNo.3a郭清
    山下裕玄,八木浩一,奥村康弘,若松高太郎,愛甲丞,西田正人,小川雅子,野村幸世,瀬戸泰之
    第72回手術手技研究会, May 2018
  • Optimal surgical approach for adenocarcinoma of the esohagogastric junction
    Hiroharu Yamashita; Yasuyuki Seto
    第90回日本胃癌学会総会, Mar. 2018

Research Themes

  • Development of human machine interface offering minimally invasive surgery based on current interaction system between surgeons
    日本大学, 令和4年度日本大学特別研究, Jul. 2022 - Mar. 2024
  • exploratory research of gut microbiota-derived metabolites
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 30 Jun. 2017 - 31 Mar. 2019
    Fujishiro Mitsuhiro
  • Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2015 - 31 Mar. 2018
    Fujishiro Mitsuhiro
  • Screening for gut microbiota-derived metabolites that stimulate intestinal stem cells
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2016 - 31 Mar. 2017
    Fujishiro Mitsuhiro
  • Systematization of the mechanism by which plasma irradiation causes cell growth and tumor cell death
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 28 Jun. 2012 - 31 Mar. 2017
    SHIMIZU Nobuyuki
  • Cancer stem cell for peritoneal metastasis in abdominal cavity
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2014
    ISHIGAMI Hironori; KITAYAMA Joji; YAMAGUCHI Hironori; YAMASHITA Hiroharu; YAZAWA Kentaro
  • Role of autophagy in immunoescape of solid tumor
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2014
    KITAYAMA JOJI; YAMASHITA Hiroharu; YAMAGUCHI Hironori; KAWAI Kazushige
  • Development of cisplutium binding hialulonic acid gel as a novel intraperitoneal chemotherapeutic agent for peritoneal dissemination of gastric cancer
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2011 - 2013
    YAMAGUCHI Hironori; KITAYAMA Joji; YAMASHITA Hiroharu; ISHIGAMI Hironori; ITOU Taichi