バイオ医薬

nanoparticle

nanomedicine

DDS

Nanotechnology/Materials, Nanobioscience, Nano Materials/Nano Bioscience

Nagai Foundation Award

Becton Dickinson Travel Grant Award

Attenuation of LPS-Induced Lung Injury by Benziodarone via Reactive Oxygen Species Reduction
Tsutomu Ishihara; Ken-ichiro Tanaka; Ayaka Takafuji; Keita Miura; Tohru Mizushima
International Journal of Molecular Sciences, Jun. 2023, Refereed, Not invited
Lead

Synthesis of tetraazacalixarene triazine-containing poly (dimethylsiloxane) with elastic property induced by pinning effect of the calixarene ring
Shibata R; Ishihara T; Tsukamoto T; Oishi Y; Fujimori A; Shibasaki Y.
European Polymer J, 2022, Refereed, Not invited

Development of liver-specific ribavirin-loaded nanoparticles with reduced cytotoxicity
Kaneko K; Ishihara T
Cogent Medicine, Dec. 2017, Refereed, Not invited
Last

Alkyne-Functionalized Cationic Polysiloxane Polymers Conjugated with Targeting Molecules by Click Reactions for DNA Delivery
Yoshihiko Kihara; Riho Maeda; Azusa Imaizumi; Tsukasa Ichikawa; Nobukatsu Nemoto; Tsutomu Ishihara; Nobutaka Hirano; Mitsuru Haruki
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Jul. 2017, Refereed, Not invited

Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells
Tsutomu Ishihara; Misaki Shibui; Takaya Hoshi; Tohru Mizushima
MOLECULAR BIOSYSTEMS, 2016, Refereed, Not invited
Lead

Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension
Tomoaki Ishihara; Erika Hayashi; Shuhei Yamamoto; Chisa Kobayashi; Yuichi Tamura; Ryoichi Sawazaki; Fumiya Tamura; Kayoko Tahara; Tadashi Kasahara; Tsutomu Ishihara; Mitsuko Takenaga; Keiichi Fukuda; Tohru Mizushima
JOURNAL OF CONTROLLED RELEASE, Jan. 2015, Refereed, Not invited

Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.
Ishihara T; Hayashi E; Yamamoto S; Kobayashi C; Tamura Y; Sawazaki R; Tamura F; Tahara K; Kasahara T; Ishihara T; Takenaga M; Fukuda K; Mizushima T.
J Control. Release, 2015, Refereed, Not invited

Development of biodegradable nanoparticles for liver-specific ribavirin delivery
Tsutomu Ishihara; Kohei Kaneko; Tomoaki Ishihara; Tohru Mizushima
J Pharm Sci., Dec. 2014, Refereed, Not invited
Lead

Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions
Yoshihiko Kihara; Tsukasa Ichikawa; Shouichi Abe; Nobukatsu Nemoto; Tsutomu Ishihara; Nobutaka Hirano; Mitsuru Haruki
POLYMER JOURNAL, Mar. 2014, Refereed, Not invited

Interactions of lecithinized superoxide dismutase with serum proteins and cells
Tsutomu Ishihara; Shunsuke Nara; Tohru Mizushima
Journal of Pharmaceutical Sciences, 2014, Refereed, Not invited
Lead

Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication
Ishihara T; Yamashita Y; Takasaki N; Yamamoto S; Hayashi E; Tahara K; Takenaga M; Yamakawa N; Ishihara T; Kasahara T; Mizushima T.
Journal of Pharmacy and Pharmacology, Aug. 2013, Refereed, Not invited

Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake
Eri Ayano; Miyuki Karaki; Tsutomu Ishihara; Hideko Kanazawa; Teruo Okano
COLLOIDS AND SURFACES B-BIOINTERFACES, Nov. 2012, Refereed, Not invited
Lead

Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives.
Saito Y; Miyamoto S; Suzuki A; Matsumoto K; Ishihara T; Saito I.
Bioorg Med Chem Lett., Apr. 2012, Refereed, Not invited

Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates.
Ishihara T.; Kano A.; Obara K.; Saito M.; Chen X.; Park T.G.; Akaike T.; Maruyama A.
J. Control. Release, Oct. 2011, Refereed, Not invited
Lead

Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis
Sakai T.; Ishihara T.; Higaki M.; Akiyama G.; Tsuneoka H.
Invest. Ophthalmol. Vis. Sci., Mar. 2011, Refereed, Not invited

Stealth-nanoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss
Horie R.; Sakamoto T.; Nakagawa T.; Ishihara T.; Higaki M.; Ito J.
Nanomedicine(Lond), Nov. 2010, Refereed, Not invited

Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation and sustained release.
Takenaga M; Ishihara T; Ohta Y; Tokura Y; Hamaguchi A; Igarashi R; Mizushima T.
J. Control. Release, Aug. 2010, Refereed, Not invited

Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
Ishihara T.; Maeda T.; Sakamoto H.; Takasaki N.; Shigyo M.; Ishida T.; Kiwada H.; Mizushima Y.; Mizushima T.
Biomacromolecules, Aug. 2010, Refereed, Not invited
Lead

Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles
Ishihara T.; Mizushima T.
Expert Opinion on Drug Delivery, May 2010, Refereed, Not invited
Lead

Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis.
Tanaka K; Ishihara T; Azuma A; Kudoh S; Ebina M; Nukiwa T; Sugiyama Y; Tasaka Y; Namba T; Ishihara T; Sato K; Mizushima Y; Mizushima T.
Am. J. Physiol. Lung Cell Mol. Physiol., Mar. 2010, Refereed, Not invited

Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents
Ishihara T; Takahashi M; Higaki M; Mizushima Y; Mizushima T.
Int. J. Pharm., Jan. 2010, Refereed, Not invited
Lead

Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Ishihara T; Takeda M; Sakamoto H; Kimoto A; Kobayashi C; Takasaki N; Yuki K; Tanaka K; Takenaga M; Igarashi R; Maeda T; Yamakawa N; Okamoto Y; Otsuka M; Ishida T; Kiwada H; Mizushima Y; Mizushima T.
Pharm. Res., Oct. 2009, Refereed, Not invited
Lead

Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model.
Matsuo Y; Ishihara T; Ishizaki J; Miyamoto K; Higaki M; Yamashita N.
Cell Immunol., Aug. 2009, Refereed, Not invited

Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles.
Takeda M; Maeda T; Ishihara T; Sakamoto H; Yuki K; Takasaki N; Nishimura F; Yamashita T; Tanaka K; Takenaga M; Igarashi R; Higaki M; Yamakawa N; Okamoto Y; Ogawa H; Otsuka M; Mizushima Y; Mizushima T.
Pharm. Res., Jul. 2009, Refereed, Not invited

Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles.
Ishihara T; Goto M; Kanazawa H; Higaki M; Mizushima Y.
J. Pharm. Sci., Jul. 2009, Refereed, Not invited
Lead

Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.
Ishihara T; Kubota T; Choi T; Takahashi M; Ayano E; Kanazawa H; Higaki M.
Int. J. Pharm., Jun. 2009, Refereed, Not invited
Lead

Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate.
Ishihara T; Kubota T; Choi T; Higaki M.
J. Pharmacol. Exp. Ther., May 2009, Refereed, Not invited
Lead

Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides.
Ishihara T; Goto M; Kodera K; Kanazawa H; Murakami Y; Mizushima Y; Higaki M.
Drug Deliv., Apr. 2009, Refereed, Not invited
Lead

Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles.
Ishihara T; Takahashi M; Higaki M; Mizushima Y.
Int. J. Pharm., Jan. 2009, Refereed, Not invited
Lead

Therapeutic effect of lecithinized superoxide dismutase against colitis.
Ishihara T; Tanaka K; Tasaka Y; Namba T; Suzuki J; Ishihara T; Okamoto S; Hibi T; Takenaga M; Igarashi R; Sato K; Mizushima Y; Mizushima T.
J. Pharmacol. Exp. Ther., Jan. 2009, Refereed, Not invited

Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles.
Ishihara T; Takahashi M; Higaki M; Takenaga M; Mizushima T; Mizushima Y.
Pharm. Res., Jul. 2008, Refereed, Not invited
Lead

Transdermal delivery of CaCO3-nanoparticles containing insulin.
Higaki M; Kameyama M; Udagawa M; Ueno Y; Yamaguchi Y; Igarashi R; Ishihara T; Mizushima Y.
Diabetes Technol Ther., Jun. 2006, Refereed, Not invited

Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate.
Sakai T; Kohno H; Ishihara T; Higaki M; Saito S; Matsushima M; Mizushima Y; Kitahara K.
Exp. Eye Res., Apr. 2006, Refereed, Not invited

Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs.
Mizushima Y; Ikoma T; Tanaka J; Hoshi K; Ishihara T; Ogawa Y; Ueno A.
J Control Release., Jan. 2006, Refereed, Not invited

Drug delivery to the cochlea using PLGA nanoparticles.
Tamura T; Kita T; Nakagawa T; Endo T; Kim TS; Ishihara T; Mizushima Y; Higaki M; Ito J.
Laryngoscope, Nov. 2005, Refereed, Not invited

Treatment of experimental arthritis with poly(D,L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate
Higaki M.; Ishihara T.; Izumo N.; Takatsu M.; Mizushima Y.
Ann. Rheum. Dis., Aug. 2005, Refereed, Not invited

Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile.
Ishihara T; Izumo N; Higaki M; Shimada E; Hagi T; Mine L; Ogawa Y; Mizushima Y.
J Control Release., Jun. 2005, Refereed, Not invited
Lead

Comb-type cationic copolymer expedites DNA strand exchange while stabilizing DNA duplex
Kim W-J.; Ishihara T.; Akaike T.; Maruyama A.
Chemistry, Jan. 2001, Refereed, Not invited

Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers
Cho C-S.; Kobayashi A.; Takei R.; Ishihara T.; Maruyama A.; Akaike T.
Biomaterials, Jan. 2001, Refereed, Not invited

Polyethyleneimine/arabinogalactan conjugate as a hepatocyte specific gene carrier
Nogawa M.; Ishihara T.; Akaike T.; Maruyama A.
S.T.P. Pharma. Sciences, Jan. 2001, Refereed, Not invited

Strand Invasion by Mixed Base PNAs and PNA-Peptide Chimera
Zhang X.; Ishihara T.; Corey D.R.
Nucleic Acid Research, Sep. 2000, Refereed, Not invited

Acceleration of DNA strand exchange by polycation comb-type copolymer.
Kim W.J; Ishihara T; Akaike T; Maruyama A
Nucleic acids symposium series, 2000, Refereed, Not invited

Reguration of DNA function by cationic graft copolymers.
Maruyama A.; Kim W-J.; Ishihara T.; Ueda M.; Torigoe H.; Ferdous A.; Akaike T.
Biomaterials and Drug Delivery toward new mellenium, Jan. 2000, Refereed, Not invited

Design of multi-layered nanoparticles as a DNA carrier
A Maruyama; T Ishihara; JS Kim; SW Kim; T Akaike
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Aug. 1999, Refereed, Not invited

Comb-type copolymers for controlled DNA delivery
Maruyama A.; Ferdous A.; Ishihara T.; Asayama S.; Park J-U.; Nogawa M.; Watanabe H.; Takei Y.; Akaike T.
Nucleosides Nucleotides, Jun. 1999, Refereed, Not invited

Dendritic graft copolymer as a hepatocyte specific DNA carrier
Park J.-U; Ishihara T; Akaike T; Maruyama A
Proceedings of the Controlled Release Society, 1999, Refereed, Not invited

Rules for strand invasion by chemically modified oligonucleotides
Ishihara T.; Corey D.R.
J. Am. Chem. Soc., Jan. 1999, Refereed, Not invited
Lead

Preparation of dendritic graft copolymer consisting of poly(L-lysine) and arabinogaractan as a hepatocyte specific DNA carrier
Park J-U.; Ishihara T.; Kano A.; Akaike T.; Maruyama A.
Prep. Biochem. Biotech., Jan. 1999, Refereed, Not invited

Design of multi-functional nanopritcles as a DNA carrier
Maruyama A.; Ishihara T.; Kim J-S.; Kim S-W.; Akaike T.
Colloids and Surfaces A, Jan. 1999, Refereed, Not invited

A Nanoparticle DNA carrier with Poly(L-lysine) grafted Polysaccharide Copolymer and Poly(D,L-lactic acid)
Maruyama A.; Ishihara T.; Akaike T.
Bioconjugate Chemistry, Sep. 1998, Refereed, Not invited

Characterization of inter polyelectrolyte complex between double stranded DNA and polylysine comb-type copolymer having hydrophilic side chains
Maruyama A.; Watanabe H.; Ferdous A.; Katoh M.; Ishihara T.; Akaike T.
Bioconjugate Chemistry, Jan. 1998, Refereed, Not invited

Simple Preparation of Nanoparticles coated with carbohydrate-carrying Polymers
Cho C-S.; Jeong Y-I.; Ishihara T.; Takei R.; Park J-U.; Park K-H.; Maruyama A.; Akaike T.
Biomaterials, Feb. 1997, Refereed, Not invited

Comb-Type Polycations Effectively stabilize DNA Triplex
Maruyama A.; Katoh M.; Ishihara T.; Akaike T.
Bioconjugate Chemistry, Jan. 1997, Refereed, Not invited

Release of cell modulators from nanoparticles coated with carbohydrate-carrying polymers
CS Cho; YI Jeong; R Takei; S Asayama; T Ishihara; A Maruyama; T Akaike
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Refereed, Not invited

Polylysine-graft-dextran copolymer as a novel type of DNA duplex stabilizer
A Maruyama; M Katoh; T Ishihara; T Akaike
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Refereed, Not invited

Design of biodegradable nanoparticles for cell-specific polynucleotides carrier
T Ishihara; A Maruyama; T Akaike; SW Kim
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Refereed, Not invited

Preparation of heterofunctional nanoparticles whose surfaces serve both DNA adsorption sites and sugar-specific recognition sites
Ishihara Tsutomu; Maruyama Atsushi; Akaike Toshihiro; Kim Sung W
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium, 1996, Refereed, Not invited

Preparation of Nanoparticles Bearing High Density of Carbohydrate Chains Using Carbohydrate Carrying Polymers as an Emulsifier
Maruyama; A. Ishihara T.; Adachi N.; Akaike T.
Biomaterials, Oct. 1994, Refereed, Not invited

Cellular Distribution of Polymer Particles bearing various densities of carbohydrate ligands
Adachi N.; Maruyama A.; Ishihara T.; Akaike T.
J. Biomater. Sci. Polymer Edn., May 1994, Refereed, Not invited

Nano PGE1製剤の外傷性脊髄損傷モデルにおける体内動態と治療効果
武永 美津子; 石原 務; 太田 有紀; 都倉 享恵; 濱口 明美; 五十嵐 理慧; 水島 徹
Drug Delivery System, May 2010, Not refereed, Not invited

ステルス型DDS製剤
炎症と免疫, Mar. 2008, Not refereed, Invited
Lead

高分子ナノ粒子
炎症と免疫, Jan. 2008, Not refereed, Invited
Lead

副作用が著しく減少すると考えられる徐放性ステロイド注射剤
水島裕、檜垣恵、石原務
炎症と免疫, Mar. 2007, Not refereed, Invited

DDSを用いた膠原病の治療-関節リウマチとナノステロイド
炎症と免疫, Feb. 2007, Not refereed, Invited
Lead

ステロイド封入ナノ微粒子
出雲信夫、石原務、水島裕
日本臨床, Feb. 2006, Not refereed, Invited

新しく開発中の薬剤①－ナノステロイド－
石原務、出雲信夫、檜垣恵、水島裕
炎症と免疫, Feb. 2005, Not refereed, Invited
Lead

ナノ微粒子製剤の開発とそのDDSへの応用
石原務、出雲信夫、水島裕
Pharm Tech Japan, Sep. 2004, Not refereed, Invited
Lead

新規ステロイドDDS製剤PLGA/PLAナノスフェア
出雲信夫、石原務
医学の歩み, Mar. 2004, Not refereed, Invited

徐放性ナノ微粒子製剤の開発
Drug Delivery System, Feb. 2004, Not refereed, Invited
Lead

遺伝子キャリヤーとバイオマテリアル
石原務; 丸山厚; 赤池敏宏
Drug Delivery System (日本DDS学会編), 2000, Not refereed, Not invited

新規モダリティ医薬品のためのDDS技術とその製剤化(薬物徐放性とターゲティング能を兼ね備えた生分解性ポリマー粒子によるDDS)
Contributor, 第1章第1節
技術情報協会, Jan. 2023

医薬品におけるDDS技術開発と製剤への応用 （脂質修飾バイオ医薬の概要と開発事例）
Contributor, 第2章第2節
情報機構, Dec. 2021, Not refereed
9784865022278

Handbook of Biomimetics
Contributor
NTS Inc., Sep. 2000, Not refereed

化学修飾によるタンパク質の細胞内デリバリー
栁沼涼祐; 三田春奈; 石原務
2023年度高分子学会東北支部研究発表会, Nov. 2023, Not invited

骨を標的としたビスホスホネート封入高分子ナノ粒子の開発
山本真大; 田口天志; 室野井実紀; 内野智裕; 石原務
2023年度高分子学会東北支部研究発表会, Nov. 2023, Not invited

Intracellular delivery of proteins by chemical modification
栁沼涼祐; 月田秀幸; 三田春奈; 石原務
International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sep. 2023, Not invited

Development of a bone-specific drug delivery system using polymeric nanoparticles modified with peptides on their surfaces
山本真大; 田口天志; 山田賢伸; 室野井実紀; 内野智裕; 石原務
International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sep. 2023, Not invited

ホスファチジルコリン修飾タンパク質の細胞内デリバリー
月田秀幸; 宗方泉稀; 松本安平; 石原務
2022年度化学系学協会東北大会, Sep. 2022, Not invited

RGDペプチドを修飾したポリ乳酸ナノ粒子の調製とその核酸医薬への応用
田口天志; 山本真大; 山田賢伸; 室野井実紀; 伊藤悟; 石原務
2022年度化学系学協会東北大会, Sep. 2022, Not invited

骨ターゲティングを目指したペプチド修飾ポリ乳酸ナノ粒子の開発
山本真大; 田口天志; 室野井実紀; 内野智裕; 石原務
2022年度化学系学協会東北大会, Sep. 2022, Not invited

機能性ポリ乳酸ナノ粒子の調製とその核酸医薬への応用
田口天志; 山本真大; 山田賢伸; 室野井実紀; 伊藤悟; 石原務
第71回高分子討論会, Sep. 2022, Not invited

Biodegradable polymer nanoparticles for drug delivery
石原務
2021年度化学系学協会東北大会, Oct. 2021

化学修飾によるタンパク質の細胞内デリバリー
三田春奈、宗方泉稀、松本安平、鈴木萌、石原務
2021年度化学系学協会東北大会, Oct. 2021, Not invited

ペプチドを表面に修飾した機能性ポリ乳酸ナノ粒子の作製
室野井実紀、宮下侑子、伊藤悟、安田京磨、石原務
2021年度化学系学協会東北大会, Oct. 2021

薬物放出速度制御とターゲッテイング能を有するポリ乳酸ナノ粒子の作製
安田京磨、吉田拓弥、石原務
2020高分子学会東北支部研究発表会, Nov. 2020, Not invited

オリゴ核酸を封入したポリ乳酸ナノ粒子の開発
伊藤悟、佐藤佳純、佐藤仁美、石原務
2020高分子学会東北支部研究発表会, Nov. 2020, Not invited

ホスファチジルコリンを化学修飾したタンパク質の合成とその活性評価
宗方泉稀、松本安平、星貴也、澁井美咲、石原務
2019年度化学系学協会東北大会, Sep. 2019, Not invited

ポリ乳酸をブレンドした脂質ナノ粒子の開発
安田京磨、吉田拓弥、石川夏子、石原務
2019年度化学系学協会東北大会, Sep. 2019, Not invited

ポリ乳酸ナノ粒子の細胞内挙動解析
長谷川萌子、伊藤悟、宮下侑子、石原務
2019年度化学系学協会東北大会, Sep. 2019, Not invited

肝星細胞へのターゲッティングを目指したナノ粒子型薬物キャリアの開発
齋藤 菜美恵・山下 勇一・石原 務
第67回高分子討論会, Sep. 2018, Not invited

ホスファチジルコリンを化学修飾したタンパク質の合成とその活性評価
松本安平・星貴也・澁井美咲・水島徹・石原務
第67回高分子討論会, Sep. 2018, Not invited

ポリ乳酸をブレンドした脂質ナノ粒子の開発
吉田拓弥・石川夏子・水島徹・石原務
第67回高分子討論会, Sep. 2018, Not invited

ポリ乳酸ナノ粒子の細胞内挙動解析
第67回高分子討論会, Sep. 2018, Not invited

肝星細胞へのターゲッティングを目指したナノ粒子型薬物キャリアの開発
齋藤奈美恵、山下勇一、石原務
第60回日本大学工学部学術研究報告会, Dec. 2017, Not invited

ポリカチオン-ポリビニルピロリドングラフトポリマーの合成とその核酸キャリアとしての評価
矢部峻暉、石原務
第60回日本大学工学部学術研究報告会, Dec. 2017, Not invited

肝星細胞特異的薬物デリバーを目指した生分解性ナノ粒子の開発
山下勇一、齋藤菜美恵、石原務
第66回高分子学会年次大会, May 2017, Not invited

肝硬変治療を目指したセレコキシブ封入ナノ粒子の開発
山下勇一、齋藤菜美恵、石原務
第59回日本大学工学部学術研究報告会, Dec. 2016, Not invited

レシチンを修飾したタンパク医薬の開発
石原務
2015高分子学会東北支部研究発表会, Nov. 2015, Not invited

肝指向性高分子ナノ粒子の開発
金子昂平、石原務
第64回高分子学会討論会, Sep. 2015, Not invited

肝炎治療を目指したリバビリン封入高分子ナノ粒子の開発
金子昂平、石原務、水島徹
第３１回日本DDS学会, Jul. 2015, Not invited

肝炎治療を目指したリバビリン封入高分子ナノ粒子の開発
金子昂平; 石原務
平成26年度化学系学協会東北大会, Sep. 2014, Not invited

薬物放出速度を制御可能な生分解性高分子ナノ粒子の開発
石原務
第３０回日本DDS学会, Jul. 2014, Invited

Development of polymeric nanoparticles for liver-specific ribavirin delivery
石原 務、平野 展孝、斉藤 義雄、春木 満、宇野 茂之、槇島 誠
平成25年度化学系学協会東北大会, Sep. 2013, Not invited

肝炎治療を目指したリバビリン封入ナノ粒子の開発
石原務、水島徹
第29回日本DDS学会, Jul. 2013, Not invited

リバビリンを封入した肝細胞特異的高分子ナノ粒子の開発
石原務、平野展孝、斉藤義雄、春木満、宇野茂之、槇島誠、水島徹
第61回高分子学会討論会, Sep. 2012, Not invited

合成高分子を用いたナノ粒子型DDS製剤の開発
石原務、平野展孝、斉藤義雄、春木満、宇野茂之、槇島誠
平成24年度 化学系学協会東北大会, Sep. 2012, Not invited

合成高分子の医薬品への利用
石原務
東北ポリマー懇話会, Dec. 2010, Not invited

DDS材料
石原務
第27回医用高分子研究会講座, Nov. 2010, Invited

生分解性高分子を用いたナノ粒子製剤の開発
石原務
平成22年度 化学系学協会東北大会, Sep. 2010, Not invited

ＰＶＰ被覆ナノ粒子によるＡＢＣ現象の回避
石原務、水島徹
第59回高分子学会年次大会, May 2010, Not invited

ステルス型生分解性ナノ粒子製剤の開発
石原務、水島徹
第58回高分子学会討論会, Sep. 2009, 熊本, Not invited

Jan. 2002 - Present
Controlled Release Society

Apr. 2001 - Present
The Japan Society of Drug Delivery System

Apr. 1997 - Present
The society of polymer science

Treatment of chronic arterial occlusion with biodegradable nanoparticles encapsulating anti-miRNA oligonucleotides
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2020 - Mar. 2023
石原 務

Development of lecithin-modified therapeutic proteins as biobetters
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2017 - Mar. 2020
Ishihara Tsutomu

Development of multifunctional polyplexes without polycations
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2014 - Mar. 2017
ISHIHARA Tsutomu

Establishment of novel therapy for hepatitis C by double DDS drugs
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2010 - 2012
ISHIHARA Tsutomu

細胞認識機能を有した新規生分解性ナノ微粒子型遺伝子キャリアーの開発
日本学術振興会, 科学研究費助成事業, 1998 - 1999
石原 務

特許番号第5780775号, 特願2011-033290, プロスタグランジンI2誘導体を含有するナノ粒子
水島徹、石原務、劉紅星

US8916206B2, Nanoparticles containing water-soluble non-peptide low-molecular weight drug
Tsutomu Ishihara, Yutaka Mizushima, Ayako Mizushima

5248487, 2009-514038, 徐放性の陰荷電基を持つ低分子薬物含有ナノ粒子
石原務、水島裕

2011-192838, 薬物を封入した肝臓集積性ナノ粒子
石原務、水島徹

3903061, 2005-516421, 薬物を含有するナノ粒子お呼びその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤
石原務、水島裕、鈴木潤、関根準三,山口葉子、五十嵐理恵