Life sciences, Respiratory medicine

Life sciences, Pharmacology

Apr. 2007 - Mar. 2010
Kumamoto University, Graduate School of Pharmaceutical Sciences, 分子機能薬学専攻

Apr. 2007 - Mar. 2010
Kumamoto University, Graduate School of Pharmaceutical Sciences, 分子機能薬学専攻

Apr. 2005 - Mar. 2007
Kumamoto University, Graduate School of Pharmaceutical Sciences, 分子機能薬学専攻

Apr. 2005 - Mar. 2007
Kumamoto University, Graduate School of Pharmaceutical Sciences, 分子機能薬学専攻

Apr. 2001 - Mar. 2005
Kumamoto University, School of pharmacy, 薬学科

★Dasatinib attenuates airway inflammation of asthma exacerbation in mice induced by house dust mites and dsRNA
Yuki Nishimoto; Daiki Ando; Kosuke Irie; Ikumi Kainuma; Yuki Katayama; Shiori Sato; Tomohiro Suzuki; Mai Harada; Tsubasa Yoshida; Kazuhiro Ito; and Yasuo Kizawa
Biochemistry and Biophysics Reports, Mar. 2023, Refereed, Not invited
Lead

★Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans pulmonary infection in mice.
Nishimoto Y; Ito K; Kimura G; Lucas K.A; Daly L; Strong P; Kizawa Y
J. Exp. Pathol., Apr. 2021, Refereed, Not invited
Lead

Anti-inflammatory Effects of a Src Inhibitor on the Murine Model of Asthma Exacerbation Induced by Ovalbumin and Lipopolysaccharide
Yuki Nishimoto; Genki Kimura; Kazuhiro Ito; Yasuo Kizawa
YAKUGAKU ZASSHI, Feb. 2023, Refereed, Not invited
Lead

Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice: Pulmonary PK-PD analysis of anti-fungal PC945
Kazuhiro Ito; Yasuo Kizawa; Genki Kimura; Yuki Nishimoto; Leah Daly; Ian Knowles; Mark Hows; John Ayrton; Pete Strong
European Journal of Pharmaceutical Sciences, Aug. 2021, Refereed, Not invited

Inhibitory effects of dabigatran on airway inflammation induced by lipopolysaccharide in mice.
Genki KIMURA; Risa TAKAHASHI; Ayaka NAGAMOTO; Kotomi YOSHINO; Keitaro UEDA; Yuki NISHIMOTO; Yasuo KIZAWA
Yakugaku Zasshi, Dec. 2020, Refereed, Not invited

Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus
Colley T; Sharma C; Alanio A; Kimura G; Daly L; Nakaoki T; Nishimoto Y; Bretagne S; Kizawa Y; Strong P; Rapeport G; Ito K; Meis JF; Chowdhary A.
J. Antimicrob. Chemother., Oct. 2019, Refereed, Not invited

The involvement of Src in airway inflammation induced by repeated exposure to lipopolysaccharide in mice
Yuki Nishimoto; Hironobu Yasuda; Keita Masuko; Yoshito Usui; Keitaro Ueda; Genki Kimura; Kazuhiro Ito; Yasuo Kizawa
YAKUGAKU ZASSHI, Sep. 2019, Refereed, Not invited
Lead

Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection
Colley T; Sehra G; Daly L; Kimura G; Nakaoki T; Nishimoto Y; Kizawa Y; Strong P; Rapeport G; Ito K.
Sci. Rep., Jul. 2019, Refereed, Not invited

TNF-α decreased corticosteroid responsiveness in mice models of airway inflammation induced by double strand RNA and/or tobacco smoke exposure
Yuki Nishimoto; Ippei Iwamoto; Ayaka Suzuki; Keitaro Ueda; Genki Kimura; Kazuhiro Ito; Yasuo Kizawa
YAKUGAKU ZASSHI, Jun. 2019, Refereed, Not invited
Lead

In vitro and in vivo efficacy of a novel and long-acting fungicidal azole, PC1244, on aspergillus fumigatus infection
Thomas Colley; Gurpreet Sehra; Anuradha Chowdhary; Alexandre Alanio; Steven L. Kelly; Yasuo Kizawa; Darius Armstrong-James; Matthew C. Fisher; Andrew G. S. Warrilow; Josie E. Parker; Diane E. Kelly; Genki Kimura; Yuki Nishimoto; Mihiro Sunose; Stuart Onions; Damien Crepin; Franz Lagasse; Matthew Crittall; Jonathan Shannon; Matthew McConville; John King-Underwood; Alan Naylor; Stéphane Bretagne; John Murray; Kazuhiro Ito; Pete Strong; Garth Rapeport
Antimicrobial Agents and Chemotherapy, May 2018, Not refereed, Not invited

Effects of intranasally dosed posaconazole on fungal load and biomarkers in Aspergillus fumigatus infected immunocompromised mice
Genki Kimura; Takahiro Nakaoki; Yuki Nishimoto; Yuto Suzuki; Garth Rapeport; Pete Strong; Kazuhiro Ito; Yasuo Kizawa
Mycoses, Nov. 2017, Refereed, Not invited

Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway
Keitaro Ueda; Yuki Nishimoto; Genki Kimura; Takashi Masuko; Peter J. Barnes; Kazuhiro Ito; Yasuo Kizawa
Biochemistry and Biophysics Reports, Sep. 2016, Refereed, Not invited

Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro
Yuki Nishimoto; Akinori Hisatsune; Hiroshi Katsuki; Takeshi Miyata; Kazumi Yokomizo; Yoichiro Isohama
Journal of Pharmacological Sciences, May 2010, Refereed, Not invited

Age-related pulmonary emphysema in mice lacking α/β hydrolase domain containing 2 gene
Shoude Jin; Gang Zhao; Zhenghua Li; Yuki Nishimoto; Yoichiro Isohama; Jingling Shen; Takaaki Ito; Motohiro Takeya; Kimi Araki; Ping He; Ken-ichi Yamamura
Biochemical and Biophysical Research Communications, Mar. 2009, Refereed, Not invited

喫煙による呼吸器疾患の病態と治療薬に関する最新の知見
西本 裕樹; 木村 元気; 木澤 靖夫
ファルマシア, 01 Aug. 2020, Not refereed
Lead

The effects of a Src inhibitor on allergic airway inflammation and its exacerbation of mice induced by house dust mite and poly(I:C)
Yuki Nishimoto; Haruka Kai; Daiki Kobayashi; Reina Kobayashi; Shoma Takahashi; Kaho Yamashita; Nozomi Yamada; Mizuki Yokota; Genki Kimura; Kazuhiro Ito; Yasuo Kizawa
The 95th Annual Meeting of the Japanese Pharmacological Society, Mar. 2022, The Japanese Pharmacological Society

Effects of protease-activated receptor antagonist on steroid insensitive airway inflammation induced by LPS in mice
Genki kimura; Yuki Nishimoto; Yasuo Kizawa
The 25th Congress of the Asian Pacific Society of Respirology, Nov. 2021, The Japanese Respiratory Society, Asian Pacific Society of Respirology, Not invited

Characterization of allergic airway inflammation induced by HDM in mice
Yuki Nishimoto; Naoki Ishikawa; Nanaka Ito; Yukiko Eguchi; Yuka Koizumi; Minami Saito; Hiroki Azami; Junichi Kashiwagi; Genki Kimura; Yasuo Kizawa
The 141st Annual Meeting of the Pharmaceutical Society of Japan, Mar. 2021, The Pharmaceutical Society of Japan, Not invited

Effects of dasatinib on airway inflammation induced by lipopolysaccharide and/or ovalbumin
Yuki Nishimoto; Yukiko Eguchi; Yuka Koizumi; Nanaka Ito; Naoki Ishikawa; Minami Saito; Genki Kimura; Yasuo Kizawa
The 94th Annual Meeting of the Japanese Pharmacological Society, Mar. 2021, The Japanese Pharmacological Society, Not invited

The effect of dasatinib on airway inflammation induced by repeated exposure of lipopolysaccharide
Yuki Nishimoto; Yuka Ikeda; Yumi Kondo; Mai Nakayama; Iori Nagakubo; Genki Kimura; Yasuo Kizawa
第143回 日本薬理学会 関東部会, Oct. 2020, Not invited

Establishment of nontypeable Heamophilus influenzae airway infection murine model
Kimura G; Nishimoto Y; Nakaoki T; Ito K; Kizawa Y
ERS International Congress 2020, Virtual congress, Sep. 2020, Not invited

Effects of PC945, a novel antifungal agent optimized for lung delivery,on Candida albicans lung infection in immunocompromised mice
Nishimoto Yuki; Kimura Genki; Nakaoki Takahiro; Strong Pete; Ito Kazuhiro; Kizawa Yasuo.
ERS International Congress 2020, Sep. 2020, European Respiratory Society, Not invited

OVA及びLPS曝露マウスにおけるステロイド治療抵抗性気道炎症に対する抗凝固薬の局所適用効果
高橋里沙、岡咲希、中村萌、長本彩花、吉野琴美、木村元気、西本裕樹、木澤靖夫
日本薬学会 第140年会, Mar. 2020, Not invited

The anti-inflammatory effects of a Src inhibitor on airway inflammation induced by ovalbumin sensitization/challenge and lipopolysaccharide exposure
Iori Nagakubo; Mai; Nakayama; Kodai Kamimura; Anna Tanaka; Keitaro Ueda; Genki Kimura; Yuki Nishimoto; Yasuo Kizawa
日本薬学会 第140年会, Mar. 2020, 日本薬学会, Not invited

The effects of a Src inhibitor on corticosteroid insensitive airway inflammation induced by lipopolysaccharide
Yumi Kondo; Yuka Ikeda; Shogo Imai; Shun Uriu; Keitaro Ueda; Genki Kimura; Yuki Nishimoto; Yasuo Kizawa
日本薬学会 第140年会, Mar. 2020, 日本薬学会, Not invited

Effects of topical dosed anti-coagulant on LPS-induced exacerbation in asthma model mice
Kimura G; Ueda K; Nishimot Y; Kizawa Y
第93回 日本薬理学会年会, Mar. 2020, Not invited

Accumulation of a novel inhaled azole, PC945, in alveolar cells in temporally neutropenic immunocompromised mice infected with Aspergillus fumigatus
Ito K; Kizawa Y; Kimura G; Nishimoto Y; Rapeport G; Strong P
9th Advances Against Aspergillosis and Mucormycosis, Feb. 2020, Not invited

Effects of a Src inhibitor, dasatinib, on allergic airway inflammation in mice induced by OVA.
Yuki Nishimoto; Sayaka Yanagi; Manami Ishizuka; Genki Kimura; Keitaro Ueda; Yasuo Kizawa
第141回 日本薬理学会 関東部会, Oct. 2019, Not invited

Allergenまたはpoly(I:C)曝露誘発気道炎症に対するdasatinibの効果
西本 裕樹、柳 沙耶佳、石塚 愛美、上田 敬太郎、木村元気、 木澤 靖夫
生体機能と創薬シンポジウム2019, Aug. 2019, 日本薬学会, Not invited

The anti-inflammatory effects of dasatinib on allergic airway inflammation in OVA-challenged mice
Sayaka Yanagi; Manami Ishizuka; Keitaro Ueda; Genki Kimura; Yuki Nishimoto; Yasuo Kizawa
日本薬学会 第139年会, Mar. 2019, 日本薬学会, Not invited

The effects of dasatinib on corticosteroid insensitive airway inflammation induced by lipopolysaccharide
Hironobu Yasuda; Keita Masuko; Yoshito Usui; Genki Kimura; Keitaro Ueda; Takashi Masuko; Kazuhiro Ito; Yuki Nishimoto; Yasuo Kizawa
第92回 日本薬理学会年会, Mar. 2019, 日本薬理学会, Not invited

マウスにおけるタバコ主流煙誘発ステロイド治療抵抗性気道炎症に対するSrc阻害薬とp38阻害薬の効果
西本 裕樹、上田 敬太郎、木村 元気、Kazuhiro Ito、木澤 靖夫
第139回 日本薬理学会 関東部会, Oct. 2018, 日本薬理学会, Not invited

タバコ主流煙またはlipopolysaccharideにより誘発したステロイド治療抵抗性及び気道過敏性を伴う気道炎症に対するp38の関与
西本裕樹、上田敬太郎、木村元気、Kazuhiro Ito、木澤 靖夫
第60回 日本平滑筋学会総会, Aug. 2018, 日本平滑筋学会, Not invited

Targeting TNF-α signaling pathway with ligand-specific antibody reverses corticosteroid insensitivity and/or airway inflammation in mice
Nishimoto Yuki; Kimura Genki; Ueda Keitaro; Ito Kazuhiro; Kizawa Yasuo.
The 18th World Congress of Basic and Clinical Pharmacology, Jul. 2018, Not invited

Antifungal effects of topical treatment of posaconazole on Aspergillus fumigatus infection in immunocompromised mice
Kimura Genki; Nakaoki Takahiro; Nishimoto Yuki; Suzuki Yuto; Masuko Takashi; Ito Kazuhiro; Kizawa Yasuo.
The 18th World congress of basic and clinical pharmacology, Jul. 2018, Not invited

マウスにおけるLPS誘発ステロイド治療抵抗性気道炎症に対する抗凝固薬局所適用の効果
大出はるか、岩本一平、勝又一葵、鈴木彩加、久住健太郎、枝さゆり、木村将大、木村元気、上田敬太郎、西本裕樹、益子 崇、木澤靖夫
日本薬学会 第138年会, Mar. 2018, 日本薬学会, Not invited

TLR3によるPTEN発現抑制を介したコルチコステロイド治療抵抗性の誘導
西本裕樹、岩本一平、大出はるか、勝又一葵、鈴木彩加、久住健太郎、枝さゆり、木村将大、上田敬太郎、木村元気、益子 崇、木澤靖夫
第138回 日本薬理学会関東部会, Mar. 2018, 日本薬理学会, Not invited

LPS及びタバコ主流煙曝露マウスにおけるステロイド治療抵抗性気道炎症に対する抗凝血薬の効果
樺澤延保、舛田千奈津、宮本瑶子、福家史織、木村元気、上田敬太郎、中沖貴宏、西本裕樹、益子崇、木澤靖夫
日本薬学会 第137年会, Mar. 2017, Not invited

dsRNA及びタバコ主流煙曝露マウスにおけるステロイド治療抵抗性気道炎症に対する抗凝血薬の効果
鈴木悠斗、山内玲奈、渡邊美月、木村元気、上田敬太郎、中沖貴宏、西本裕樹、益子崇、木澤靖夫
日本薬学会 第137年会, Mar. 2017, Not invited

The effects of anti-TNF-α antibody on corticosteroid refractory airway inflammation in mice
Nishimoto Y; Kimura G; Ueda K; Nakaoki T; Masuko T; Kizawa Y
第90回日本薬理学会年会, Mar. 2017, Not invited

The combination of TNF-α neutralization and dexamethasone treatment restored the corticosteroid responsiveness in tobacco smoking mice
Nishimoto Y; Kimura G; Ueda K; Nakaoki T; Ito K; Kizawa Y
The 26th ERS International Congress, Sep. 2016, Not invited

Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice
Kimura G; Nishimoto Y; Ueda K; Nakaoki T; Masuko T; Barnes PJ; Ito K; Kizawa Y.
The 26th ERS International Congress, Sep. 2016, Not invited

Theophyllineは卵白アルブミン感作マウスにおけるタバコ主流煙及びallergen曝露誘発気道炎症のステロイド治療感受性を改善させる
木村元気、上田敬太郎、西本裕樹、益子崇、Kazuhiro Ito、木澤靖夫
第134回 日本薬理学会関東部会, Jul. 2016, 日本薬理学会

気道炎症に対するtheophyllineの効果
木村元気、上田敬太郎、西本裕樹、益子崇、Kazuhiro Ito、木澤靖夫
第56回 日本呼吸器学会学術講演会, Apr. 2016, 日本呼吸器学会

Ovalbumin及びpolyinosinic-polycytidylic acid曝露マウスにおけるステロイド治療抵抗性気道炎症に対するPI3K阻害薬の効果
鍋田侑李、橋本莉佐、小杉麻衣、渋谷映人、木村元気、上田敬太郎、中沖貴宏、西本裕樹、益子崇、草間貞、木澤靖夫
日本薬学会 第136年会, Mar. 2016, 日本薬学会

Combination treatment of anti-TNF-α antibody and dexamethasone suppresses steroid insensitive airway inflammation
Nishimoto Y; Kimura G; Ueda K; Nakaoki T; Masuko T; Kusama T; Kizawa Y.
第89回 日本薬理学会年会, Mar. 2016, 日本薬理学会

ステロイド治療抵抗性とhistone deacetylase2、およびsirtuin1の関連
西本裕樹、木村元気、上田敬太郎、中沖貴宏、草間貞、木澤靖夫
第59回 日本薬学会関東支部大会, Sep. 2015, 日本薬学会

The effect of interleukine-17 induced by cigarette smoke on steroid sensitivity in mice
Yuki Nishimoto; Genki Kimura; Keitaro Ueda; Tadashi Kusama; Yasuo Kizawa
日本薬学会 第134年会, Mar. 2014, 日本薬学会