大西 彰

生物資源科学部 諸課程教授

研究者情報

研究分野

  • ライフサイエンス, 動物生命科学
研究活動情報

論文

  • Development of human hepatocellular carcinoma in X-linked severe combined immunodeficient pigs: An orthotopic xenograft model
    Kohei Mishima 1; Osamu Itano 1 2; Sachiko Matsuda 1; Shunichi Suzuki 3; Akira Onishi 3 4; Masashi Tamura 5; Masanori Inoue 5; Yuta Abe 1; Hiroshi Yagi 1; Taizo Hibi 6; Minoru Kitago 1; Masahiro Shinoda 1; Yuko Kitagawa
    PLos One, 2021年03月, 査読有り, 通常論文
    責任著者
  • Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model
    Suguru Migita 1 2; Daisuke Kitano 2; Yuxin Li 3; Yutaka Koyama 1 2; Sayaka Shimodai-Yamada 1; Akira Onishi 4; Daiichiro Fuchimoto 5; Shunichi Suzuki 5; Yoshiyuki Nakamura 6; Taka-Aki Matsuyama 7; Seiichi Hirota 8; Masashi Sakuma 9; Masahiko Tsujimoto 10; Atsushi Hirayama 11; Yasuo Okumura 2; Hiroyuki Hao
    Sci.Rep, 2021年03月, 査読有り, 通常論文
    責任著者
  • Organogenesis of Ileal Peyer's Patches Is Initiated Prenatally and Accelerated Postnatally With Comprehensive Proliferation of B Cells in Pigs
    Mutsumi Furukawa 1; Shun Ito 1; Shunichi Suzuki 2; Daiichiro Fuchimoto 2; Akira Onishi 3; Kanae Niimi 1; Katsuki Usami 1; Guoyao Wu 4; Fuller W Bazer 4; Kouetsu Ogasawara 5; Kouichi Watanabe 1; Hisashi Aso 1; Tomonori Nochi
    Front Immunol, 2020年12月, 査読有り
    責任著者
  • Effect of pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modular (SPPARMα), in atherosclerosis model using low density lipoprotein receptor knock-out swine with balloon injury
    Hirokazu Konishi 1; Katsumi Miyauchi 1; Akira Onishi 2; Shunichi Suzuki 3; Daiichiro Fuchimoto 3; Jun Shitara 1; Hirohisa Endo 1; Hideki Wada 1; Shinichiro Doi 1; Ryo Naito 1; Manabu Ogita 1; Tomotaka Dohi 1; Takatoshi Kasai 1; Hiroyuki Daida
    PLos One, 2020年11月, 査読有り, 通常論文
    責任著者
  • Elucidation of the Effects of a Current X-SCID Therapy on Intestinal Lymphoid Organogenesis Using an In Vivo Animal Model.
    Nochi T; Suzuki S; Ito S; Morita S; Furukawa M; Fuchimoto D; Sasahara Y; Usami K; Niimi K; Itano O; Kitago M; Matsuda S; Matsuo A; Suyama Y; Sakai Y; Wu G; Bazer FW; Watanabe K; Onishi A; Aso H.Nochi T; et al.
    Cell Mol Gastroenterol Hepatol., 2020年02月, 査読有り
  • Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections.
    Onishi T; Matsuda S; Nakamura Y; Kuramoto J; Tsuruma A; Sakamoto S; Suzuki S; Fuchimoto D; Onishi A; Chikaki S; Kaneko M; Kuwahata A; Sekino M; Yasuno H; Hanyu N; Kurita T; Takei H; Sakatani T; Taruno K; Nakamura S; Hayashida T; Jinno H; Kusakabe M; Handa H; Kameyama K; Kitagawa Y.Onishi T; et al.
    J Histochem Cytochem., 2019年08月, 査読有り
  • Establishment of a model of sentinel lymph node metastasis using immunodeficient swine.
    Kurihara T; Matsuda S; Nakamura Y; Suzuki S; Fuchimoto D; Onishi A; Saeki K; Nakagawa T; Fujiwara R; Kamata M; Kuramoto J; Kameyama K; Sekino M; Kusakabe M; Hayashida T; Jinno H; Kitagawa Y.Kurihara T; et al.
    Sci Rep., 2019年05月, 査読有り
  • Establishment of a strain of haemophilia-A pigs by xenografting of foetal testicular tissue from neonatally moribund cloned pigs.
    Kaneko H1; Kikuchi K2; 3; Nakai M2; 4; Fuchimoto D5; Suzuki S6; Sembon S2; 4; Noguchi J2; Onishi A
    Sci Rep, 2017年12月, 査読有り
  • 教育に向けたマウス体外受精
    大西彰、三角浩司
    日本大学生物資源科学部教職課程紀要, 2017年09月, 査読有り
    筆頭著者
  • Lack of calcium oscillation causes failure of oocyte activation after intracytoplasmic sperm injection in pigs.
    Nakai M; Ito J; Suzuki SI; Fuchimoto DI; Senbon S; Suzuki M; Noguchi J; Kaneko H; Onishi A; Kashiwazaki N; Kikuchi K.
    J Reprod Dev., 2016年12月, 査読有り, 通常論文
  • Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency.
    Suzuki S; Iwamoto M; Hashimoto M; Suzuki M; Nakai M; Fuchimoto D; Sembon S; Eguchi-Ogawa T; Uenishi H; Onishi A.
    Vet Immunol Immunopathol., 2016年10月, 査読有り
  • Somatic cell reprogramming-free generation of genetically modified pigs.
    Tanihara F; Takemoto T; Kitagawa E; Rao S; Do LT; Onishi A; Yamashita Y; Kosugi C; Suzuki H; Sembon S; Suzuki S; Nakai M; Hashimoto M; Yasue A; Matsuhisa M; Noji S; Fujimura T; Fuchimoto D; Otoi T.
    Sci Adv., 2016年09月, 査読有り
  • Efficient pig ICSI using Percoll-selected spermatozoa; evidence for the essential role of phospholipase C-ζ in ICSI success.
    Nakai M; Suzuki SI; Ito J; Fuchimoto DI; Sembon S; Noguchi J; Onishi A; Kashiwazaki N; Kikuchi K.
    J Reprod Dev., 2016年09月, 査読有り
  • Development of Accelerated Coronary Atherosclerosis Model Using Low Density Lipoprotein Receptor Knock-Out Swine with Balloon Injury.
    Ogita M; Miyauchi K; Onishi A; Tsuboi S; Wada H; Konishi H; Naito R; Dohi T; Kasai T; Kojima Y; Schwartz RS; Daida H.
    PLoS One, 2016年09月, 査読有り
  • Production of Piglets Using Sperm Retrieved from Host Mice Harboring Fetal Testicular Tissue of F8 Gene- Targeted Hemophilia A Pigs
    Hiroyuki Kaneko; Kazuhiro Kikuchi; Michiko Nakai; Daiichiro Fuchimoto; Shunichi Suzuki; Shoichiro Sembon; Junko Noguchi; Akira Onishi
    49th Annual Meeting of the Society for the Study of Reproduction,, 2016年09月, 査読有り
  • Development of Human-Like Advanced Coronary Plaques in Low-Density Lipoprotein Receptor Knockout Pigs and Justification for Statin Treatment Before Formation of Atherosclerotic Plaques.
    Li Y; Fuchimoto D; Sudo M; Haruta H; Lin QF; Takayama T; Morita S; Nochi T; Suzuki S; Sembon S; Nakai M; Kojima M; Iwamoto M; Hashimoto M; Yoda S; Kunimoto S; Hiro T; Matsumoto T; Mitsumata M; Sugitani M; Saito S; Hirayama A; Onishi A.
    J Am Heart Assoc., 2016年04月, 査読有り
    責任著者
  • Conserved and divergent expression patterns of markers of axial development in eutherian mammals
    Yoshida M; Kajikawa E; Kurokawa D; Tokunaga T; Ohnishi A; Yonemura S; Kobayashi K; Kiyonari H; Aizawa S
    Developmental Dynamics, 2016年, 査読有り
  • Treatment with protein kinase C activator is effective for improvement of male pronucleus formation and further embryonic development of sperm-injected oocytes in pigs
    Nakai M; Ito J; Kashiwazaki N; Men N.T; Tanihara F; Noguchi J; Kaneko H; Onishi A; Kikuchi K
    Theriogenology, 2016年, 査読有り
  • Functional difference between membrane-bound and soluble human thrombomodulin
    Miwa Y; Yazaki S; Iwamoto M; Suzuki S; Iwasaki K; Haneda M; Yamamoto K; Maruyama S; Onishi A; Kobayashi T
    Transplantation, 2015年, 査読有り
  • Is early statin treatment justified before formation of atherosclerotic plaques?
    II.Li Y; Onishi A; Sudo M; Haruta H; Lin Q-F; Takayama T; Suzuki S; Fuchimoto D; Sembon S; Iwamoto M; Hashimoto M; Yoda S; Kunimoto S; Hiro T; Matsumoto T; Mitsumata M; Sugitani M; Saito S; Hirayama A
    Circulation, 2015年, 査読有り, 通常論文
  • Growth, reproductive performance, carcass characteristics, and meat quality in F1 and F2 progenies of somatic cell-cloned pigs
    Adachi N; Yamaguchi D; Watanabe A; Miura N; Sunaga S; Oishi H; Hashimoto M; Oishi T; Iwamoto M; Hanada H; Kubo M; Onishi A
    Journal of Reproduction and Development, 2014年, 査読有り
  • Transcriptional and histological analyses of the thymic developmental process in the fetal pig
    Suzuki S; Suzuki M; Nakai M; Sembon S; Fuchimoto D; Onishi A
    Experimental Animals, 2014年, 査読有り
  • Delay in cleavage of porcine embryos after intracytoplasmic sperm injection (ICSI) shows poorer embryonic development
    Nakai M; Ozawa M; Maedomari N; Noguchi J; Kaneko H; Ito J; Onishi A; Kashiwazaki N; Kikuchi K
    Journal of Reproduction and Development, 2014年, 査読有り
  • Midkine promotes neuroblastoma through Notch2 signaling
    Kishida S; Mu P; Miyakawa S; Fujiwara M; Abe T; Sakamoto K; Onishi A; Nakamura Y; Kadomatsu K
    Cancer Research, 2013年, 査読有り
  • In vitro fertilization and development of porcine oocytes matured in follicular fluid
    Agung B; Otoi T; Fuchimoto D; Senbon S; Onishi A; Nagai T
    Journal of Reproduction and Development, 2013年, 査読有り
  • Characterization of actions of octanoate on porcine preadipocytes and adipocytes differentiated in vitro
    Suzuki S; Suzuki M; Sembon S; Fuchimoto D; Onishi A
    Biochemical and Biophysical Research Communications, 2013年, 査読有り
  • Generation of pig primary fibroblast cells harboring defective MC4R genes by N-ethyl-N-nitrosourea mutagenesis: A gene-driven, nontransgenic approach to pig improvement
    Sakurai M; Suzuki S; Furusawa T; Mikawa S; Tokunaga T; Onishi A; Awata T
    American Journal of Molecular Biology, 2013年, 査読有り
  • AMP-activated protein kinase as a promoting factor, but complement and thrombin as limiting factors for acquisition of cytoprotection: Implications for induction of accommodation
    Iwasaki K; Miwa Y; Haneda M; Kuzuya T; Ogawa H; Onishi A; Kobayashi T
    Transplant International, 2013年, 査読有り

MISC

  • 免疫不全ブタ
    大西彰
    腎と透析, 2015年12月, 査読無し
    筆頭著者
  • 遺伝子改変ブタの開発
    大西彰
    LABIO 21, 2014年10月, 査読無し
    筆頭著者

書籍等出版物

  • ★ゲノム編集食品 農林水産分野への応用と持続的社会の実現
    分担執筆, ゲノム編集によるブタの遺伝子改変, 大西彰
    株式会社 エヌ・ティー・エス, 2021年02月, 査読無し
  • ブタ・ミニブタ実験マニュアル 飼育管理から、関連法規、実験手技、周術管理まで
    編者(編著者), ブタ・ミニブタ実験マニュアル編集委員会 大竹俊男、大西彰、大和田一雄、堤秀樹
    丸善出版, 2017年08月
    9784904419700