OHASHI Akiko
| School of Dentistry Department of Dentistry | Senior Assistant Professor |
Researcher Information
Research activity information
Paper
- CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice.
Naoya Nishitani; Yu Ohmura; Kazuki Nagayasu; Norihiro Shibui; Shuji Kaneko; Akiko Ohashi; Takayuki Yoshida; Akihiro Yamanaka; Mitsuhiro Yoshioka
Brain Research, Sep. 2019, Refereed, Not invited - Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting β-catenin signal pathway in vitro.
Cell Tissue Res, 2019, Refereed, Not invited - Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess
Akiko Ohashi; Kaori Mamada; Tomonori Harada; Masako Naito; Tomihisa Takahashi; Shin Aizawa; Hiroyuki Hasegawa
MOLECULAR AND CELLULAR BIOCHEMISTRY, Nov. 2017, Refereed, Not invited - Lamin A overexpression promotes osteoblast differentiation and calcification in the MC3T3-E1 preosteoblastic cell line
Naoya Tsukune; Masako Naito; Tatsuya Kubota; Yasumasa Ozawa; Mayu Nagao; Akiko Ohashi; Shuichi Sato; Tomihisa Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2017, Refereed, Not invited - Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism.
Oguri Y; Fujita Y; Abudukadier A; Ohashi A; Goto T; Furuya F; Obara A; Fukushima T; Matsuo N; Kim M; Hosokawa M; Kawada T; Hasegawa H; Inagaki N.
JCI Insight, 2017, Refereed, Not invited - Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats.
Ohashi A; Saeki Y; Harada T; Naito M; Takahashi T; Aizawa S; Hasegawa H.
PLoS One, Oct. 2016, Refereed, Not invited
Lead - Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5
Masako Naito; Souksavanh Vongsa; Naoya Tsukune; Akiko Ohashi; Tomihisa Takahashi
MOLECULAR AND CELLULAR ENDOCRINOLOGY, Dec. 2015, Refereed, Not invited - Dexamethasone inhibits chondrocyte differentiation by suppression of Wnt/beta-catenin signaling in the chondrogenic cell line ATDC5
Masako Naito; Akiko Ohashi; Tomihisa Takahashi
HISTOCHEMISTRY AND CELL BIOLOGY, Sep. 2015, Refereed, Not invited - Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase-Dependent Manner in Diabetic Mice
Abulizi Abudukadier; Yoshihito Fujita; Akio Obara; Akiko Ohashi; Toru Fukushima; Yuichi Sato; Masahito Ogura; Yasuhiko Nakamura; Shimpei Fujimoto; Masaya Hosokawa; Hiroyuki Hasegawa; Nobuya Inagaki
DIABETES, Sep. 2013, Not refereed, Not invited - Rapid clearance of supplemented tetrahydrobiopterin is driven by high-capacity transporters in the kidney
Akiko Ohashi; Yasuko Suetake; Yusuke Saeki; Tomonori Harada; Shin Aizawa; Hiroyuki Hasegawa
MOLECULAR GENETICS AND METABOLISM, Apr. 2012, Refereed, Not invited - Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the lumenal surface of rat endothelial cells
Akiko Ohashi; Kaori Mamada; Isao Tsuboi; Shin Aizawa; Hiroyuki Hasegawa
MOLECULAR GENETICS AND METABOLISM, Nov. 2011, Refereed, Not invited - Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis.
Ohashi A; Sugawara Y; Mamada K; Harada Y; Sumi T; Anzai N; Aizawa S; Hasegawa H
Molecular genetics and metabolism, Jan. 2011, Refereed, Not invited - Membrane Transport of Sepiapterin and Dihydrobiopterin by Equilibrative Nucleoside Transporters: a Plausible Gateway for the Salvage Pathway of Tetrahydrobiopterin Biosynthesis.
Ohashi A; Sugawara Y; Mamada K; Harada Y; Sumi T; Anzai N; Aizawa S; Hasegawa H.
Mol Genet Metab, 2011, Refereed, Not invited
Lead - テトラヒドロビオプテリンの細胞膜輸送体活性の測定: アフリカツメガエル卵母細胞による輸送体遺伝子発現系の応用.
大橋 晶子,菅原 ゆうこ,真々田 薫,安西 尚彦,相澤 信,長谷川 宏幸
ビタミン, 2011, Refereed, Not invited
Lead - テトラヒドロピオプテリンの吸収，分布，排出:補充療法の可能性を探る
大橋 晶子
ビタミン, 2010, Refereed, Not invited
Lead - Transcellular relocation of tetrahydrobiopterin across Caco-2 cells: A model study of tetrahydrobiopterin absorption through epithelial cells of intestinal mucosa
A. Ohashi; M. Fukumuro; K. Sawabe; K. Mamada; Y. Sugawara; H. Matsuoka; H. Hasegawa
JOURNAL OF INHERITED METABOLIC DISEASE, Feb. 2009, Refereed, Not invited - Tetrahydrobiopterin in intestinal lumen: Its absorption and secretion in the small intestine and the elimination in the large intestine
K. Sawabe; Y. Saeki; A. Ohashi; K. Mamada; K. O. Wakasugi; H. Matsuoka; H. Hasegawa
JOURNAL OF INHERITED METABOLIC DISEASE, Feb. 2009, Refereed, Not invited - Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin
Keiko Sawabe; Kazumasa Yamamoto; Yoshinori Harada; Akiko Hashi; Yuko Sugawara; Hiroshi Matsuoka; Hiroyuki Hasegawa
MOLECULAR GENETICS AND METABOLISM, Aug. 2008, Refereed, Not invited - Role of a serotonin precursor in development of gut microvilli.
Nakamura K; Sato T; Ohashi A; Tsurui H; Hasegawa H.
Am J Pathol, 2008, Refereed, Not invited - Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
K Nakamura; Y Sugawara; K Sawabe; A Ohashi; H Tsurui; Y Xiu; M Ohtsuji; QS Lin; H Nishimura; H Hasegawa; S Hirose
JOURNAL OF NEUROSCIENCE, Jan. 2006, Refereed, Not invited - Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.
Nakamura K; Koyama Y; Takahashi K; Tsurui H; Xiu Y; Ohtsuji M; Lin QS; Sugawara Y; Sawabe K; Ohashi A; Ohnuma T; Arai H; Nishimura H; Hasegawa H; Hirose S.
J Mol Biol, 2006, Refereed, Not invited
Lectures, oral presentations, etc.
- モノアミン産生細胞におけるテトラヒドロビオプテリンの2つの効果
日本ビタミン学会第71回大会, 2019, Not invited - テトラヒドロビオプテリンのプロドラッグ(セピアプテリン)投与による脳内セロトニン生合成活性の促進
第124回日本解剖学会総会・全国学術集会, 2019, Not invited - Tetrahydrobiopterin Is Required for Brown Adipose Tissue Development and Differentiation
The 11th Scientific Meeting of the Asian Association for the Study of Diabetes, 2019, Not invited - Tetrahydrobiopterin Regulates Developmental Differentiation of Brown Adipose Tissue
79th American Diabetes Association, 2019, Not invited - モノアミン生合成を調節するテトラヒドロビオプテリンの細胞膜輸送
大橋 晶子,原田 智則,髙橋 富久,相澤 信,長谷川 宏幸
日本ビタミン学会第70回大会, Jun. 2018, Not invited - テトラヒドロビオプテリンの尿中排出における有機陰イオン輸送体の役割
大橋 晶子,内藤 昌子,二宮 禎,髙橋 富久
第123回日本解剖学会総会・全国学術集会, Mar. 2018, Not invited - テトラヒドロビオプテリンによる褐色脂肪組織の発生・分化機構の解明
第32回日本プテリジン研究会, 2018, Not invited - 有機陰イオン輸送体はBH4の尿中排出に関わる
第31回日本プテリジン研究会, Nov. 2017, Not invited - Rapid clearance of supplemented tetrahydrobiopterin is driven by organic anion transporters, OAT1 and OAT3
第59回歯科基礎医学会学術大会, Sep. 2017, Not invited - セピアプテリンの末梢投与による脳内トリプトファンレベルの変動
日本ビタミン学会第69回大会, Jun. 2017, Not invited - 肥満細胞におけるテトラヒドロビオプテリンによるセロトニン生合成の促進
第58回歯科基礎医学会学術大会, Aug. 2016, Not invited - セピアプテリンの末梢投与による脳内カテコールアミン生合成の促進
日本ビタミン学会第68回大会, Jun. 2016, Not invited - テトラヒドロビオプテリンによる糖・脂質およびエネルギー代謝制御機構の解明
第59回日本糖尿病学会年次学術集会, May 2016, Not invited - FcεRI活性化は肥満細胞株RBL2H3におけるトリプトファン水酸化酵素の発現を促進する
第57回歯科基礎医学会学術大会, Sep. 2015, Not invited - テトラヒドロビオプテリンのサルベージ経路前駆体セピアプテリンの末梢投与による，脳内補酵素の導入
第56回歯科基礎医学会学術大会, Sep. 2014, Not invited - 脳内セロトニンレベルの決定要因としてのトリプトファン水酸化酵素の活性促進について
第18回活性アミンに関するワークショップ, Aug. 2014, Not invited - セピアプテリン投与による脳内セロトニンの生合成促進と代謝回転の亢進
日本ビタミン学会第66回大会, Jun. 2014, Not invited
