Life sciences, Pathobiochemistry

Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion
Mustafa Yalcinkaya; Panagiotis Fotakis; Wenli Liu; Kaori Endo-Umeda; Huijuan Dou; Sandra Abramowicz; Tong Xiao; Peter Libby; Nan Wang; Alan R Tall; Marit Westerterp
Cardiovascular Research, Dec. 2022, Refereed

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Wenli Liu; Nataliya Östberg; Mustafa Yalcinkaya; Huijuan Dou; Kaori Endo-Umeda; Yang Tang; Xintong Hou; Tong Xiao; Trevor P. Fidler; Sandra Abramowicz; Yong-Guang Yang; Oliver Soehnlein; Alan R. Tall; Nan Wang
Journal of Clinical Investigation, Jul. 2022, Refereed

Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis
Kaori Endo-Umeda; Eunyoung Kim; David G. Thomas; Wenli Liu; Huijuan Dou; Mustafa Yalcinkaya; Sandra Abramowicz; Tong Xiao; Per Antonson; Jan-Åke Gustafsson; Makoto Makishima; Muredach P. Reilly; Nan Wang; Alan R. Tall
Arteriosclerosis, Thrombosis, and Vascular Biology, Jun. 2022, Refereed
Lead

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency
Huijuan Dou; Andriana Kotini; Wenli Liu; Trevor Fidler; Kaori Endo-Umeda; Xiaoli Sun; Malgorzata Olszewska; Tong Xiao; Sandra Abramowicz; Mustafa Yalcinkaya; Brian Hardaway; Sotirios Tsimikas; Xuchu Que; Alexander Bick; Conor Emdin; Pradeep Natarajan; Eirini P. Papapetrou; Joseph L. Witztum; Nan Wang; Alan R. Tall
Circulation, Dec. 2021, Refereed

Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice
Kaori Endo-Umeda; Hiroyuki Nakashima; Shigeyuki Uno; Shota Toyoshima; Naoki Umeda; Shihoko Komine-Aizawa; Shuhji Seki; Makoto Makishima
Scientific Reports, Nov. 2021, Refereed
Lead

Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation
Takuya Ishikiriyama; Hiroyuki Nakashima; Kaori Endo-Umeda; Masahiro Nakashima; Seigo Ito; Manabu Kinoshita; Masami Ikarashi; Makoto Makishima; Shuhji Seki
PLOS ONE, Jul. 2021, Refereed

Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives
Tatsuma Nishioka; Kaori Endo-Umeda; Yuki Ito; Akane Shimoda; Atsuko Takeuchi; Chisato Tode; Yoshihisa Hirota; Naomi Osakabe; Makoto Makishima; Yoshitomo Suhara
Molecules, Nov. 2019, Refereed

Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells
Kaori Endo-Umeda; Makoto Makishima
International Journal of Molecular Sciences, Oct. 2019, Refereed
Lead

Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab
Takaaki Maekawa; Shoichiro Kato; Toshikuni Kawamura; Kohei Takada; Takehiro Sone; Hiraku Ogata; Keita Saito; Takuya Izumi; Shigeki Nagao; Kosuke Takano; Yosuke Okada; Noriaki Tachi; Masahiro Teramoto; Toshikatsu Horiuchi; Reina Hikota-Saga; Kaori Endo-Umeda; Shigeyuki Uno; Yukiko Osawa; Ayako Kobayashi; Shinichi Kobayashi; Ken Sato; Michihiro Hashimoto; Shinya Suzu; Kensuke Usuki; Soji Morishita; Marito Araki; Makoto Makishima; Norio Komatsu; Fumihiko Kimura
Blood, Sep. 2019, Refereed

Frontline Science: Concanavalin A-induced acute hepatitis is attenuated in vitamin D receptor knockout mice with decreased immune cell function
Naoki Umeda; Kaori Endo-Umeda; Hiroyuki Nakashima; Shigeaki Kato; Shuhji Seki; Makoto Makishima
Journal of Leukocyte Biology, Apr. 2019, Refereed

Liver X receptors regulate hepatic F4/80 + CD11b+ Kupffer cells/macrophages and innate immune responses in mice
Kaori Endo-Umeda; Hiroyuki Nakashima; Shihoko Komine-Aizawa; Naoki Umeda; Shuhji Seki; Makoto Makishima
Scientific Reports, Dec. 2018, Refereed
Lead

Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXR α Knockout Male Mice
Kaori Endo-Umeda; Hiroyuki Nakashima; Naoki Umeda; Shuhji Seki; Makoto Makishima
Endocrinology, Mar. 2018, Refereed
Lead

Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility
Sayaka Nomura; Kaori Endo-Umeda; Shinya Fujii; Makoto Makishima; Yuichi Hashimoto; Minoru Ishikawa
Bioorganic and Medicinal Chemistry Letters, Feb. 2018, Refereed

1 alpha-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators
Kaori Endo-Umeda; Atsushi Aoyama; Masato Shimizu; Minoru Ishikawa; Yuichi Hashimoto; Sachiko Yamada; Makoto Makishima
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Sep. 2017, Refereed
Lead

Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists
Sayaka Nomura; Kaori Endo-Umeda; Makoto Makishima; Yuichi Hashimoto; Minoru Ishikawa
ChemMedChem, 2016, Refereed

Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells
Satoshi Nunomura; Yoshimichi Okayama; Kenji Matsumoto; Noriko Hashimoto; Kaori Endo-Umeda; Tadashi Terui; Makoto Makishima; Chisei Ra
Allergology International, Sep. 2015, Refereed

Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators
Sayaka Nomura; Kaori Endo-Urneda; Atsushi Aoyama; Makoto Makishima; Yuichi Hashimoto; Minoru Ishikawat
ACS MEDICINAL CHEMISTRY LETTERS, Aug. 2015, Refereed

7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity
Kaori Endo-Umeda; Kaori Yasuda; Kazuyuki Sugita; Akira Honda; Miho Ohta; Minoru Ishikawa; Yuichi Hashimoto; Toshiyuki Sakaki; Makoto Makishima
The Journal of Steroid Biochemistry and Molecular Biology, Mar. 2014, Refereed
Lead

Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain
Toru Imai; Yasuhiro Kosuge; Kaori Endo-Umeda; Hiroko Miyagishi; Kumiko Ishige; Makoto Makishima; Yoshihisa Ito
AMINO ACIDS, Feb. 2014, Refereed

Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice
Jun Ozeki; Mihwa Choi; Kaori Endo-Umeda; Kenichi Sakurai; Sadao Amano; Makoto Makishima
Neuropeptides, Oct. 2013, Refereed

Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages
Manabu Matsunawa; Daisuke Akagi; Shigeyuki Uno; Kaori Endo-Umeda; Sachiko Yamada; Kazumasa Ikeda; Makoto Makishima
Drug Metabolism and Disposition, Nov. 2012, Refereed

Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.
Atsushi Aoyama; Kaori Endo-Umeda; Kenji Kishida; Kenji Ohgane; Tomomi Noguchi-Yachide; Hiroshi Aoyama; Minoru Ishikawa; Hiroyuki Miyachi; Makoto Makishima; Yuichi Hashimoto
Journal of medicinal chemistry, Sep. 2012, Refereed

Differential expression and function of alternative splicing variants of human liver X receptor α.
Kaori Endo-Umeda; Shigeyuki Uno; Ko Fujimori; Yoshikazu Naito; Koichi Saito; Kenji Yamagishi; Yangsik Jeong; Hiroyuki Miyachi; Hiroaki Tokiwa; Sachiko Yamada; Makoto Makishima
Molecular pharmacology, Jun. 2012, Refereed
Lead

Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer
Masayuki Chuma; Kaori Endo-Umeda; Shigeki Shimba; Sachiko Yamada; Makoto Makishima
Biological and Pharmaceutical Bulletin, Apr. 2012, Refereed

Mast cell death induced by 24(S),25-epoxycholesterol
Makiko Fukunaga; Satoshi Nunomura; Shigeru Nishida; Kaori Endo; Yasuhiro Gon; Shu Hashimoto; Yuichi Hashimoto; Yoshimichi Okayama; Makoto Makishima; Chisei Ra
Experimental Cell Research, Nov. 2010, Refereed

Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners
Satoshi Nunomura; Kaori Endo; Makoto Makishima; Chisei Ra
FEBS Letters, Mar. 2010, Refereed

CYP1A1 and CYP1A2 expression: Comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines
Shigeyuki Uno; Kaori Endo; Yuji Ishida; Chise Tateno; Makoto Makishima; Katsutoshi Yoshizato; Daniel W. Nebert
Toxicology and Applied Pharmacology, May 2009, Refereed

Suppression of beta-catenin signaling by liver X receptor ligands.
Shigeyuki Uno; Kaori Endo; Yangsik Jeong; Katsuyoshi Kawana; Hiroyuki Miyachi; Yuichi Hashimoto; Makoto Makishima
Biochemical pharmacology, Jan. 2009, Refereed

The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages
Manabu Matsunawa; Yusuke Amano; Kaori Endo; Shigeyuki Uno; Toshiyuki Sakaki; Sachiko Yamada; Makoto Makishima
Toxicological Sciences, 2009, Refereed

Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene
Kaorl Endo; Shigeyuki Uno; Taiichiro Seki; Toyohiko Ariga; Yoshiaki Kusumi; Masako Mitsumata; Sachiko Yamada; Makoto Makishima
TOXICOLOGY AND APPLIED PHARMACOLOGY, Jul. 2008, Refereed
Lead

ステロール代謝酵素CYP27A1による7-デヒドロコレステロール代謝産物の同定及び核内受容体LXRの転写活性化能に対する影響
梅田 香織; 遠藤; 安田 佳織; 杉田 和幸; 本多 彰; 太田 美穂; 石川 稔; 橋本 祐一; 榊 利之; 槇島 誠
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Not refereed, Not invited

Vitamin D receptor activation enhances Benzo[a] pyrene metabolism via CYP1A1 expression in macrophages
Shigeyuki Uno; Manabu Matsunawa; Daisuke Akagi; Kaori Endo-Umeda; Kazumasa Ikeda; Makoto Makishima
FASEB JOURNAL, Apr. 2013, Not refereed, Not invited

肝臓免疫細胞におけるVDR依存性の機能発現の解析
槇島 誠; 梅田香織; 山口凉香; 山岸賢司
第377回脂溶性ビタミン総合研究委員会, Sep. 2023, Not invited

ミエロイド系細胞特異的LXR欠損における泡沫化マクロファージの炎症誘導及び動脈硬化促進作用
梅田(遠藤)香織
第45回日本分子生物学会年会, Dec. 2022, Not invited

核内受容体liver X receptorによるナチュラルキラーT細胞分布及び肝臓抗腫瘍活性制御
梅田(遠藤)香織; 中島弘幸; 宇野茂之; 豊島翔太; 梅田 直; 相澤(小峯)志保子; 関 修司; 槇島 誠
日本レチノイド研究会 第33回学術集会, Oct. 2022, Not invited

Liver X receptors regulate natural killer T cell population and hepatic antitumor activity in mice
Kaori Endo-Umeda; Hiroyuki Nakashima; Shota Toyoshima; Shihoko Komine-Aizawa; Shuhji Seki; Makoto Makishima
第50回日本免疫学会学術集会, Dec. 2021, Not invited

核内受容体liver X receptorによるナチュラルキラーT細胞分布及び肝臓抗腫瘍活性制御
梅田(遠藤)香織; 中島弘幸; 宇野茂之; 豊島翔太; 梅田 直; 相澤(小峯)志保子; 関 修司; 槇島 誠
第44回日本分子生物学会年会, Dec. 2021, Not invited

シングルセル解析から読み解く非アルコール性脂肪肝炎の病態制御
日本大学学術研究助成金 [独創的・先駆的研究], Apr. 2023 - Mar. 2025
梅田 香織; 槇島 誠; 和田 平; 山岸 賢司

核内受容体LXRが制御する肝臓免疫細胞間相互作用の解析
日本学術振興会, 科学研究費助成事業, Apr. 2021 - Mar. 2024
梅田 香織

アテローム性動脈硬化症進展における新規NETosis制御メカニズムの解明
公益財団法人 小野医学研究財団 研究奨励助成金, 2022
梅田 香織

核内受容体による肝臓免疫細胞ネットワークの解析
公益財団法人 アステラス病態代謝研究会 研究助成金, 2022
梅田 香織

アテローム性動脈硬化症進展におけるNETosisの新規制御メカニズムの解明
公益財団法人 金原一郎記念医学医療振興財団, 第37回基礎医学医療研究助成金, 2022
梅田 香織

Effects of liver X receptor on regulation of NKT cell-induced inflammation and antitumor activity
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2020 - Mar. 2021
ENDO-UMEDA Kaori

ビタミンD受容体シグナルによる肝臓免疫細胞制御機構の解析
日本大学 若手研究者環境整備支援助成金, 2021
梅田 香織

核内受容体LXRによる肝臓マクロファージ制御機構の解明と非アルコール性脂肪性肝疾患への影響
公益財団法人 武田科学振興財団 医学系研究助成, 2021
梅田 香織

核内受容体LXRによるNETosisおよび動脈硬化進展抑制メカニズムの解明
公益信託 循環器学研究振興基金 研究助成, 2020
梅田 香織

Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2013 - 31 Mar. 2016
MAKISHIMA Makoto; SEKI Shuji; UMEDA Kaori; ISHIZAWA Michiyasu; YAMADA Sachiko; NISHIDA Shigeru; UMEDA Naoki

Effects of LXR on innate immune responses in hepatic mononuclear cells
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2013 - Mar. 2016
ENDO-UMEDA Kaori

肝免疫系細胞における脂質代謝及び自然免疫調節機構に対する核内受容体LXRの影響
日本大学医学部助成金土岐研究, Apr. 2013 - Mar. 2014
梅田 香織

Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2010 - 2012
MAKISHIMA Makoto; SAKURAI Kenichi; UMEDA Kaori; SEKI Shuji; ISHIZAWA Michiyasu