血液

播種性血管内凝固症候群

血栓・止血異常症

動物

止血凝固異常症

Life sciences, Veterinary medicine, Veterinary Hematology

Life sciences, Veterinary medicine, Veterinary clinical medicine

Apr. 2020 - Present
日本大学 生物資源科学部 獣医学科, 准教授

Apr. 2015 - Mar. 2020
日本大学 生物資源科学部 獣医学科, 専任講師

Mar. 2016 - Mar. 2017
Cornell University, College of Veterinary Medicine, Research Scholar

Apr. 2010 - Mar. 2015
日本大学 生物資源科学部 獣医学科, 助教

Apr. 2006 - Mar. 2010
日本大学 生物資源科学部 獣医学科, 助手

01 Apr. 2001 - 31 Mar. 2005
Nihon University, Graduate School, Division of Veterinary Medicine, Course in Veterinary Medicine

Apr. 2001 - Mar. 2005
Nihon University, Graduate School, Division of Veterinary Medicine, Course in Veterinary Medicine

01 Apr. 2001 - 2001
Nihon University, Faculty of Agriculture and Veterinary Medicine, Department of veterinary medicine

2001
Nihon University, Faculty of Agriculture and Veterinary Medicine, Department of veterinary medicine

日本獣医学会, 日本獣医学会 Good Reviewer賞

日本獣医内科学アカデミー／日本獣医臨床病理学会 研究アワード
イヌADAMTS13活性測定法に関する研究

High‐output heart failure secondary to severe chronic anaemia in a dog
Seijirow Goya; Haruhiko Maruyama; Tomohiro Nakayama
Veterinary Record Case Reports, Aug. 2024
Corresponding

ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats
Dana N. LeVine; Linda Kidd; Oliver A. Garden; Marjory B. Brooks; Robert Goggs; Barbara Kohn; Andrew J. Mackin; Erin R. B. Eldermire; Yu‐Mei Chang; Julie Allen; Peter W. Christopherson; Barbara Glanemann; Haruhiko Maruyama; Maria C. Naskou; Lise N. Nielsen; Sarah Shropshire; Austin K. Viall; Adam J. Birkenheuer; Marnin A. Forman; Andrew S. Hanzlicek; Kathrin F. Langner; Erin Lashnits; Katharine F. Lunn; Kelly M. Makielski; Xavier Roura; Eva Spada
Journal of Veterinary Internal Medicine, May 2024, Refereed, Not invited

Preliminary Evaluation of a Flow Cytometric Assay with Microsphere Controls for Detection of Platelet Bound Antibodies in Canine Immune Thrombocytopenia
Marjory B. Brooks; Haruhiko Maruyama; Signe E. Cremer; Robert Goggs; Marnin A. Forman; Michael Koch; Julia Merriam; Kelly Makielski; Austin Viall; Dana N. LeVine
Veterinary Clinical Pathology, 2021, Refereed

Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations.
Maruyama H; Brooks MB; Stablein A; Frye A.
Gene, 2019, Refereed, Not invited
Lead

A novel missense mutation in the factor XII gene in a litter of cats with factor XII deficiency
Haruhiko Maruyama; Haruki Hosoe; Kota Nagamatsu; Rui Kano; Hiroshi Kamata
JOURNAL OF VETERINARY MEDICAL SCIENCE, May 2017, Refereed, Not invited
Lead

Evaluation of a disintegrin-like and metalloprotease with thrombospondin type 1 repeat motifs 13 (ADAMTS13) activity enzyme-linked immunosorbent assay for measuring plasma ADAMTS13 activity in dogs
Haruhiko Maruyama; Michiko Kaneko; Taiga Otake; Rui Kano; Yoshiki Yamaya; Toshihiro Watari; Atsuhiko Hasegawa; Hiroshi Kamata
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, Mar. 2014, Refereed, Not invited
Lead

NOD2 mRNA Expression and NFkappaB Activation in Dogs with Lymphocytic Plasmacytic Colitis
H. Okanishi; K. Hayashi; Y. Sakamoto; T. Sano; H. Maruyama; Y. Kagawa; T. Watari
JOURNAL OF VETERINARY INTERNAL MEDICINE, May 2013, Refereed, Not invited

Molecular cloning, in vitro expression and functional characterization of canine ADAMTS13
H. Maruyama; K. Ito; K. Okabayashi; M. Sakai; R. Kano; T. Watari; A. Hasegawa; H. Kamata
RESEARCH IN VETERINARY SCIENCE, Aug. 2012, Refereed, Not invited
Lead

Therapeutic Efficacy of ABT-737, a Bcl-2 Inhibitor, in a Canine Melanoma Cell Line
Mai Uwano; Rui Kano; Haruhiko Maruyama; Atsuhiko Hasegawa; Hiroshi Kamata
JOURNAL OF VETERINARY MEDICAL SCIENCE, Jun. 2012, Refereed, Not invited

The antagonist activity of lipid IVa on the stimulation by lipid A of TNF-alpha production from canine blood mononuclear cells
Kenji Takasawa; Rui Kano; Haruhiko Maruyama; Atsuhiko Hasegawa; Hiroshi Kamata
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Sep. 2011, Refereed, Not invited

Chronic ulcerative dermatitis caused by Fusarium sporotrichioides.
Kano R; Maruyama H; Kubota M; Hasegawa A; Kamata H.
Med Mycol., Apr. 2011, Refereed, Not invited

An azole-resistant isolate of Malassezia pachydermatis
Kano R; Maruyama H; Kubota M; Hasegawa A; Kamata H
Veterinary Microbiology, Feb. 2011, Refereed, Not invited

Small Interfering RNA (siRNA) against the Survivin Gene Increases Apoptosis in a Canine Melanoma Cell Line.
Moriyama M; Kano R; Maruyama H; Hasegawa A; Kamata H.
J Vet Med Sci., Dec. 2010, Refereed, Not invited

Detection of autoantibodies against survivin in sera from cancer dogs.
Tango Y; Kano R; Maruyama H; Asano K; Tanaka S; Hasegawa A; Kamata H.
J Vet Med Sci., Jul. 2010, Refereed, Not invited

Small Interfering RNA (siRNA) against the Bcl-2 Gene Increases Apoptosis in a Canine Melanoma Cell Line.
Watanabe Y; Kano R; Maruyama H; Hasegawa A; Kamata H.
J Vet Med Sci., Mar. 2010, Refereed, Not invited

26S rDNA-Based Phylogenetic Investigation of Japanese Cattle-Associated Prototheca zopfii Isolates.
Kishimoto Y; Kano R; Maruyama H; Onozaki M; Makimura K; Ito T; Matsubara K; Hasegawa A; Kamata H.
J Vet Med Sci., Jan. 2010, Refereed, Not invited

Confirmed case of feline mycetoma due to Microsporum canis.
Kano; R.; Edamura; K.; Yumikura; H.; Maruyama; H.; Asano; K.; Tanaka; S. and Hasegawa; A.
Mycoses., Jan. 2009, Refereed, Not invited

Reticulated platelet levels in whole blood and plate-rich plasma of dogs with various platelet counts measured by flow cytometry.
Maruyama; H.; Yamagami; H.; Watari; T.; Kano; R.; Fujino; Y.; Tsujimoto; H.; Hasegawa; A. and Kamata; H.
J. Vet. Med. Sci., 2009, Refereed, Not invited
Lead

Effectiveness of small interfering RNA (siRNA) against the Mcl-1 gene in a canine mammary gland tumor cell line.
Kano R; Yano T; Nagamatsu K; Maruyama H; Kamata H; Hasegawa A.
Res. Vet. Sci., 2009, Refereed, Not invited

Antifungal activity of itraconazole and voriconazole against clinical isolates obtained from animals with mycoses.
Okabayashi K; Imaji M; Osumi T; Murakami Y; Maruyama H; Kano R; Hasegawa A; Watanabe T.
Jap. J. Med. Mycol., 2009, Refereed, Not invited

Prototheca zopfii genotypes isolated from cow barns and bovine mastitis in Japan.
Osumi; T.; Kishimoto; Y.; Kano; R.; Maruyama; H.; Onozaki; M.; Makimura; K.; Ito; T.; Matsubara; K. and Hasegawa; A.
Vet. Microbiol., Oct. 2008, Refereed, Not invited

The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line.
Kota Nagamatsu; Fumito Tsuchiya; Keisuke Oguma; Haruhiko Maruyama; Rui Kano; Atsuhiko Hasegawa.
Research in Veterinary Science, Jan. 2008, Refereed, Not invited
Corresponding

Cloning of canine Toll-like receptor 7 gene and its expression in dog tissues.
Yasuhumi Okui; Rui Kano; Haruhiko Maruyama; Atsuhiko Hasegawa.
Veterinary Immunology and Immunopathology, Jan. 2008, Refereed, Not invited
Corresponding

Molecular Cloning of Canine Mucosal Addressin Cell Adhesion Molecule-1 cDNA and its Expression in Normal Tissues.
Teruhisa Miura, Toshihiro Watari, Haruhiko Maruyama, Manabu Sakai, Tomoko Takahashi, Rui Kano, Hiroshi Koie, Yoshiki Yamaya, Mikihiko Tokuriki, Atsuhiko Hasegawa
J. Vet. Med. Sci., Nov. 2005, Refereed, Not invited

Plasma thrombin-antithrombin complex concentrations in dogs with malignant tumours.
H Maruyama, T Watari, T Miura, M Sakai, T Takahashi, H Koie, Y Yamaya, K Asano, K Edamura, T Sato, S Tanaka, A Hasegawa, M Tokuriki
The Veterinary Reccord, Jun. 2005, Refereed, Not invited
Lead

Molecular cloning of canine thrombomodulin cDNA and expression in normal tissues.
Haruhiko Maruyama, Keisuke Oguma, Sadatoshi Maeda, Rui Kano, Hajime Tsujimoto, Toshihiro Watari, Mikihiko Tokuriki, Atsuhiko Hasegawa
J. Vet. Med. Sci., Nov. 2004, Refereed, Not invited
Lead

The incidence of disseminated intravascular coagulation in dogs with malignant tumor.
Haruhiko Maruyama, Teruhisa Miura, Manabu Sakai, Hiroshi Koie, Yoshiki Yamaya, Hisashi Shibuya, Tsuneo Sato, Toshihiro Watari, Akira Takeuchi, Mikihiko Tokuriki, Atsuhiko Hasegawa
J. Vet. Med. Sci., May 2004, Refereed, Not invited
Lead

Endoscopic findings on alimentary lymphoma in 7 dogs.
Miura T, Maruyama H, Sakai M, Takahashi T, Koie H, Yamaya Y, Shibuya H, Sato T, Watari T, Tokuriki M, Hasegawa A.
J. Vet. Med. Sci., May 2004, Refereed, Not invited

Effects of DDAVP administrated subcutaneously in dogs with aspirin-induced platelet dysfunction and hemostatic impairement due to chronic liver disease.
Manabu Sakai, Toshihiro Watari, Teruhisa Miura, Haruhiko Maruyama, Hiroshi Koie, Yoshiki Yamaya, Akira Takeuchi, Atsuhiko Hasegawa
J. Vet. Med. Sci., Jan. 2003, Refereed, Not invited

DIC 播種性血管内凝固症候群
Infovets, May 2013, Not refereed, Not invited
Lead

出血・血栓性疾患に関連した検査
SA Medicine, Apr. 2013, Not refereed, Not invited

脾臓腫瘍に随伴する止血異常の病態と対応
亘敏広、丸山治彦
SURGEON, Mar. 2007, Not refereed, Not invited

犬の慢性肝疾患における腹腔鏡下門脈造影およびひ髄内圧測定の有効性
坂井学; 浅野和之; 三浦輝久; 丸山治彦; 高橋朋子; 鯉江洋; 山谷吉樹; 亘敏広; 徳力幹彦
Twig’s, 2004

悪性腫ようり患犬におけるトロンビン-アンチトロンビン複合体(TAT)を用いた血液凝固こう進状態の把握
丸山治彦; 亘敏広; 三浦輝久; 坂井学; 高橋朋子; 鯉江洋; 山谷吉樹; 浅野和之; 枝村一弥
日本獣医学会学術集会講演要旨集, 2004

犬の慢性肝疾患における腹腔鏡下門脈造影およびひ髄内圧測定の有効性
坂井学; 浅野和之; 三浦輝久; 丸山治彦; 高橋朋子; 鯉江洋; 山谷吉樹; 亘敏広; 徳力幹彦
日本獣医学会学術集会講演要旨集, 2003

犬猫の各種疾患における抗核抗体の検出
原田佳代子; 三浦輝久; 坂井学; 丸山治彦; 鯉江洋; 森友忠昭; 中西照幸; 竹内啓; 徳力幹彦
日本獣医学会学術集会講演要旨集, 2002

コアカリ 獣医内科学Ⅲ 神経病学・血液免疫病学・皮膚病学
Contributor, 出血・血栓性疾患
文永堂出版, Nov. 2019

薬用量マニュアル、第4版
Contributor, 止血薬・抗血栓薬・造血薬
日本小動物獣医師会, 2016, Not refereed

薬用量マニュアル、第3版
Contributor, 止血薬・抗血栓薬・造血薬
日本小動物獣医師会, Oct. 2011, Not refereed

猫の医学
Contributor, 血液・免疫疾患
時事通信社, Jul. 2011, Not refereed

犬の医学
Contributor, 血液・免疫疾患
時事通信社, Jul. 2011, Not refereed

日本大学動物病院来院犬における β１‐Tubulin 遺伝子変異（c.745G>A）の保有状況
西村 咲; 尾崎 菜々子; 加藤 久美; 守澤 美里亜; 鎌田 寛; 丸山 治彦
日本獣医臨床病理学会2023年次大会, Sep. 2023

猫の先天性第XII因子欠乏症における遺伝子変異の調査
日本獣医臨床病理学会 2019年大会, Jun. 2019, Not invited

Mutations causing feline factor XII deficiency in the United States
Haruhiko Maruyama; Amelia Frye; Marjory Brooks
American College of Veterinary Internal Medicine Forum 2017, Jun. 2017, Not invited

腫瘍罹患犬における血中ADAMTS13 活性の検討
日本獣医臨床病理学会 2015年大会, May 2015, Not invited

IDENTIFICATION OF A MISSENSE MUTATION IN THE FACTOR XII GENE IN SIBLING CATS WITH FACTOR XII DEFICIENCY.
H. Maruyama; H. Hosoe; K. Nagamatsu; R. Nagamatsu; R. Kano; T. Watari and H. Kamata.
American college of veterinary internal medicine forum 2014, Jun. 2014, Not invited

ネコ第XII因子欠乏症の遺伝子解析
細江春樹、丸山治彦、永松航太、永松亮一、加納 塁、鎌田 寛
日本獣医臨床病理学会2013年大会, Jun. 2013, Not invited

CONGENITAL FACTOR VII DEFICIENCY IN PAPILLON DOGS.
H. Maruyama; K. Kinmoto; R. Kano; T. Watari and H. Kamata.
2013 American college of veterinary internal medicine forum, Jun. 2013, Not invited

Evaluation of a human ELISA kit for the measurement of plasma ADAMTS13 activity in dogs.
H. Maruyama; T. Ohtake; M. Kaneko; R. Kano; Y. Yamaya; T. Watari; H. Kamata.
2012 American college of veterinary internal medicine forum, May 2012, Not invited

イヌADAMTS13活性測定法に関する研究
大竹 大賀、丸山 治彦、金子 倫子、亘 敏広、鎌田 寛
日本獣医内科学アカデミー 2011年大会, Mar. 2011, Not invited

重篤な出血症状を呈した第VII因子欠乏症の雑種犬の1例
丸山治彦、福永恵太、鎌田 寛、亘 敏広.
獣医臨床遺伝研究会第１９年会, Sep. 2010, Not invited

止血凝固検査の基礎講座
JCVIM/JSVCP 2010, Feb. 2010, Not invited

播種性血管内凝固症候群
日本比較臨床医学会, Nov. 2009, Not invited

止血凝固異常症 －出血性疾患を中心に－
丸山治彦
JCVIM/JSVCP 2009, Feb. 2009, Not invited

リンパ腫罹患犬における血液凝固活性亢進と炎症の関連性
丸山治彦、亘 敏広、加納 塁、鎌田 寛
日本大学獣医学会, Jun. 2008, Not invited

ネコリンパ腫由来細胞株における抗癌剤感作時のBcl-2ファミリー遺伝子の発現
小澤友美、丸山治彦、加納塁、長谷川篤彦
日本獣医内科学アカデミー学術大会, Aug. 2007, Not invited

RNAi法を用いたイヌのMcl-1の抗腫瘍効果について
矢野貴之、丸山治彦、加納塁、長谷川篤彦
日本獣医内科学アカデミー学術大会, Aug. 2007, Not invited

RNAi法を用いたイヌのBcl-2の機能解析
永松航太、丸山治彦、加納 塁、長谷川篤彦
日本獣医内科学アカデミー学術大会, Aug. 2006, Not invited

悪性腫瘍罹患犬の末梢血白血球におけるトロンボモジュリンと組織因子のmRNA発現解析
丸山治彦、高橋朋子、坂井 学、加納 塁、亘 敏広、徳力幹彦、長谷川篤彦
日本獣医内科学アカデミー総会, Aug. 2005, Not invited

悪性腫瘍罹患犬におけるトロンビン－アンチトロンビン複合体（TAT）を用いた血液凝固亢進状態の把握
丸山治彦、亘 敏広、三浦輝久、坂井 学、高橋朋子、鯉江 洋、山谷吉樹、浅野和之、枝村一弥、佐藤常男、田中茂男、長谷川篤彦、徳力幹彦
日本獣医学会, Apr. 2004, Not invited

犬の腫瘍疾患における播種性血管内凝固症候群（DIC)の発生頻度
丸山治彦、三浦輝久、坂井 学、鯉江 洋、山谷吉樹、渋谷 久、佐藤常男、亘 敏広、竹内 啓、徳力幹彦
日本獣医学会, Sep. 2002, Not invited

Oct. 2013 - Present
動物臨床医学会

Feb. 2013 - Present
日本獣医臨床病理学会

Jun. 2009 - Present
日本検査血液学会

May 2006 - Present
The Japanese Society on Thrombosis and Hemostasis

Apr. 2006 - Present
日本大学獣医学会

Mar. 2004 - Present
The Japanese Society of Veterinary Science

Jun. 2010 - 2016
日本血液学会

重症化モデルから播種性血管内凝固（DIC）のトリガーを見つける
日本学術振興会, 科学研究費助成事業, 01 Apr. 2025 - 31 Mar. 2030
岩永 朋子; 伊藤 隆史; 岡田 英志; 畑井 仁; 高橋 雅; 丸山 治彦; 三浦 直樹

播種性血管内凝固の早期診断の確立：NETsに関連した臨床マーカーはどれか
日本学術振興会, 科学研究費助成事業, Apr. 2022 - Mar. 2025
岩永 朋子; 福島 隆治; 齋藤 靖生; 伊藤 隆史; 畑井 仁; 高橋 雅; 丸山 治彦; 三浦 直樹

新規抗血栓薬の開発に向けた猫の先天性血液凝固第XII因子欠乏症の病態解明
Apr. 2018 - Mar. 2021

犬の血栓症におけるADAMTS13およびVWFを中心とした病態追究
Apr. 2013 - Mar. 2016

犬の血栓症におけるADAMTS13を用いた新規診断・治療法の確立に向けた基盤研究
Apr. 2011 - Mar. 2012

犬における播種性血管内凝固症候群の発現機序に関する研究
日本大学, 日本大学学術助成金〔奨励研究〕, 2007 - 2007

siRNAを用いた小動物の腫瘍に対する治療法の開発
2007 - 2007