Tani Hiroyuki
| College of Bioresource Sciences Department of Veterinary Medicine | Assistant Professor |
Researcher Information
promotion
Profile (Promotion)
獣医学；獣医腫瘍内科学；小動物臨床腫瘍学；分子標的治療；化学療法；放射線治療；橋渡し研究；臨床試験
Veterinary medicine; veterinary oncology; small animal clinical oncology; molecular targeted therapy; chemotherapy; radiation therapy; bridging research; clinical trials, 犬や猫の悪性腫瘍（がん）に対する新しい治療法の確立を目指して研究を行っています。
We are researching to establish new treatment methods for malignant tumors in dogs and cats.
Research Keyword
Field Of Study
Educational Background
Research activity information
Paper
- ★Electrocardiography‐gated cardiac computed tomography angiography using a non‐helical 320‐row area detector for assessment of treatment response in a dog with a heart base tumour
H. Tani; S. Goya; N. Shiozawa; C. Ishikawa; T. Nakayama
Journal of Small Animal Practice, Apr. 2025, Refereed
Lead - ★Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines
H. Sakuma; H. Tomiyasu; A. Tani; Y. Goto-Koshino; H. Tani; K. Ohno; H. Tsujimoto; M. Bonkobara; M. Okuda
The Veterinary Journal, Dec. 2024, Refereed - ★A case report of feline mast cell tumour with intertumoral heterogeneity: Identification of secondary mutations c.998G>C and c.2383G>C in KIT after resistance to toceranib
Hiroyuki Tani; Tatsuro Hifumi; Keita Ito; Tomohide Kuramoto; Noriaki Miyoshi; Makoto Fujiki; Tomohiro Nakayama
Veterinary Medicine and Science, Aug. 2024, Refereed
Lead - ★A feline case of multiple myeloma treated with bortezomib.
Tani H; Miyamoto R; Miyazaki T; Oniki S; Tamura K; Bonkobara M
BMC Veterinary Research, Nov. 2022, Refereed
Lead - ★EFFECTS OF CO-ADMINISTRATION OF MOLECULAR TARGETDRUGS IN CANINE HISTIOCYTIC SARCOMA CELL LINES
Sakuma Hiroki; Tani Akiyoshi; Asada Hajime; Goto-Koshino Yuko; Tani Hiroyuki; Ohno Koichi; Tsujimoto Hajime; Bonkobara Makoto; Tomiyasu Hirotaka
Abstracts from the 2021 Veterinary Cancer Society (VCS) Annual Conference, 4–6 November 2021, Jan. 2022, Refereed - ★Molecular characterization of canine SHP2 mutants and anti-tumor effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma
Tani H; Miyamoto R; Nagashima T; Michishita M; Tamura K; Bonkobara M
Veterinary and comparative oncology, Jul. 2021, Refereed
Lead - ★A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis
Hiroyuki Tani; Ryo Miyamoto; Syunya Noguchi; Sena Kurita; Tomokazu Nagashima; Masaki Michishita; Naoko Yayoshi; Kyoichi Tamura; Makoto Bonkobara
BMC Veterinary Research, Apr. 2021, Refereed
Lead - ★Commitment toward cell death by activation of autophagy with survivin inhibitor YM155 in two canine squamous cell carcinoma cell lines with high expression of survivin
Ryo Miyamoto; Hiroyuki Tani; Tomoyo Ikeda; Hono Saima; Kyoichi Tamura; Makoto Bonkobara
Research in Veterinary Science, Oct. 2020, Refereed - ★Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099.
Hiroyuki Tani; Sena Kurita; Ryo Miyamoto; Kazuhiko Ochiai; Kyoichi Tamura; Makoto Bonkobara
Veterinary and comparative oncology, Jun. 2020, Refereed, Not invited
Lead - ★Nimustine treatment of 11 cases of canine histiocytic sarcoma.
Tani H; Kurita S; Miyamoto R; Sawada H; Fujiwara-Igarashi A; Michishita M; Azakami D; Hasegawa D; Tamura K; Bonkobara M
Journal of American Animal Hospital Association., May 2020, Refereed, Not invited
Lead - ★Genetic alterations of KIT during clonal expansion and subsequent acquisition of resistance to toceranib in a canine mast cell tumor cell line.
Sena Kurita; Ryo Miyamoto; Hiroyuki Tani; Masato Kobayashi; Takashi Sasaki; Kyoichi Tamura; Makoto Bonkobara
Journal of veterinary pharmacology and therapeutics, Nov. 2019, Refereed, Not invited - ★Expression and Genetic Variation of Apoptosis Inhibitor of Macrophage in Canine Histiocytic Sarcoma.
Uchida M; Uchida K; Tani H; Bonkobara M; Maeda S; Yonezawa T
2019 ACVIM Forum Research Abstract Program, Sep. 2019, Refereed, Not invited - ★YM155 Inhibits the Growth of Canine Squamous Cell Carcinoma Cells with High Expression of Survivin.
Miyamoto R; Tani H; Kurita S; Ikeda T; Ishizaka M; Saima H; Tamura K; Bonkobara M
2018 ACVIM Forum Research Abstract Program., Oct. 2018, Refereed, Not invited - ★Treatment of Histiocytic Sarcoma with Nimustine in Dogs: 9 Cases.
Tani H; Kurita S; Miyamoto R; Tamura K; Bonkobara M
2018 ACVIM Forum Research Abstract Program., Oct. 2018, Refereed, Not invited
Lead - ★Canine squamous cell carcinoma cell lines with high expression of survivin are sensitive to survivin inhibitor YM155.
R Miyamoto; S Kurita; H Tani; T Ikeda; M Ishizaka; H Saima; M Kobayashi; K Tamura; M Bonkobara
Veterinary journal (London, England : 1997), Oct. 2018, Refereed, Not invited - ★The Surivine Inhibitor YM155 unduses Apoptotic Cell Death And Non-Apoptotic Cell Death In Canine Squamous Cell Carcinoma Cells.
Miyamoto R; Kurita S; Tani H; Ikeda T; Ishizuka M; Saima H; Kobayashi M; Tamura K; Bonkobara M
Proceeding of the 18th Biennial Congress of The International Society for Animal Clinical Pathology., Aug. 2018, Refereed, Not invited - ★Establishment and characterization of a cell line from a feline histiocytic sarcoma
Ryo Miyamoto; Sena Kurita; Hiroyuki Tani; Masato Kobayashi; Soudai Sugiura; Kae Shigihara; Yuka Sato; Yoshikazu Tanaka; Kyoichi Tamura; Makoto Bonkobara
Veterinary Immunology and Immunopathology, Jul. 2018, Refereed, Not invited - ★Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2
K. Ito; R. Miyamoto; H. Tani; S. Kurita; M. Kobayashi; K. Tamura; M. Bonkobara
Journal of Veterinary Pharmacology and Therapeutics, Feb. 2018, Refereed, Not invited - ★A decrease in ubiquitination and resulting prolonged life-span of KIT underlies the KIT overexpression-mediated imatinib resistance of KIT mutation-driven canine mast cell tumor cells
Masato Kobayashi; Shiori Kuroki; Sena Kurita; Ryo Miyamoto; Hiroyuki Tani; Kyoichi Tamura; Makoto Bonkobara
Oncology Reports, Oct. 2017, Refereed, Not invited - ★Selective growth inhibition by suppression of F1Fo ATPase in canine malignant melanoma cell lines
S. Kuroki; M. Kobayashi; H. Tani; R. Miyamoto; S. Kurita; K. Tamura; K. Ono; T. Washizu; M. Bonkobara
Journal of Veterinary Pharmacology and Therapeutics, Jan. 2017, Refereed, Not invited
MISC
- 化学療法の有害反応と緊急事の対応ーいざという時に焦らないための対応策！ 発熱性好中球減少症
谷 浩由輝
Veterinary Oncology, Apr. 2024
Lead - 病理とエビデンスによる腫瘍の治療戦略 [第6回] 犬の皮膚・皮下肥満細胞腫
谷浩由輝; 榎本薫子; 鈴木学; 近藤広考
CAP, Feb. 2024
Lead - 臨床を支える日本の研究～執筆者からの提言～ "犬組織球性肉腫 11 症例に対するニムスチン治療"
谷浩由輝
SA Medicine, Feb. 2023
Lead - 特集：犬の腫瘍別プロトコル解説集 抗がん剤の組み合わせを理解する！（多発性骨髄腫）
谷浩由輝
VETERINARY ONCOLOGY no. 36, Nov. 2022 - Molecular-targeted drugs (small molecular compounds) and molecular-targeted therapy for mast cell tumor
Hiroyuki Tani
Japanese Journal of Veterinary Clinical Oncology, Jul. 2022
Lead - 特集 血球異常～数の評価～ 各論②「白血球」
谷 浩由輝
CLINIC NOTE, Apr. 2022, Not refereed
Lead - ニッポンの研究 犬の変異SHP2における分子生物学的特徴と犬組織球性肉腫細胞の担癌マウスモデルを用いたSHP2阻害薬SHP099の抗腫瘍効果の検討
谷 浩由輝
VETERINARY ONCOLOGY No.33, Jan. 2022, Not refereed
Lead - 第１特集 犬と猫の臨床看護ガイド 出血「口から血が出ている」～犬の悪性黒色腫に対する動物看護～
中村迪香; 谷浩由輝; 呰上大吾
動物看護専門誌as, May 2021, Not refereed - Vet’s VOICE 第5回｢腫瘍治療のブレイクスルーを担う獣医師を目指して｣
谷浩由輝
月刊「CAP」～小動物獣医師のための臨床総合誌～, Jan. 2019, Not refereed, Not invited - ACNUにより治療した組織球性肉腫の犬の5例
飯島しずか; 谷浩由輝; 栗田晟那; 宮本良; 澤田治美; 安田暁子; 盆子原誠; 田村恭一
日本獣医臨床病理学会大会プロシーディング, Jun. 2017, Not refereed, Not invited - 犬の悪性黒色腫4例に対するボルテゾミブの効果に関する検討
谷浩由輝; 山本仁美; 栗田晟那; 宮本良; 小野憲一郎; 田村恭一; 盆子原誠
日本獣医臨床病理学会大会プロシーディング, May 2016, Not refereed, Not invited - 外科的処置を実施した先天性第VII因子欠乏症のビーグルの1例
谷浩由輝; 池田美奈子; 下島怜; 伊藤秀俊; 南智彦; 溝口やよい; 高橋賢一郎; 小野沢栄里; 呰上大吾; 呰上大吾
獣医臨床病理, 30 Dec. 2015, Not refereed, Not invited
Books and other publications
Lectures, oral presentations, etc.
- Medical treatment and genetic abnormality in feline mast cell tumors
Hiroyuki Tani
The 31th Main Symposium of Japan Veterinary Cancer Society - Mast Cell Tumor in Cats, Jan. 2025, Invited - Treatment with bortezomib for feline plasma cell neoplasms in three cases.
諸橋寧々; 濱田芙優; 比良岡祐也; 塩澤直子; 石川智恵子; 近藤広孝; 中山智宏; 谷浩由輝
JVCS the 31th Conference, Jan. 2025, Not invited - A web-based-system of Japan Veterinary Cancer Registry (JVCR) for dogs and cats with cancer was launched
Takayuki Nakagawa; Daigo Azakami; Masaya Igase; Daiki Kato; Kosuke Kobayashi; Kosei Sakai; Hiroyuki Tani; Hirotaka Tomiyasu; Kenji Hosoya; Naoki Miura; Ryo Miyamoto; Hiroki Sugiyama; Michio Fujita; Takuo Ishida
World Veterinary Cancer Congress Tokyo, Mar. 2024, Not invited - 強度変調回転放射線治療を実施した胸腺腫の犬の一例
植田紗妃; 佐藤麗奈; 猪飼えり; 諸橋寧々; 石川智恵子; 高野雅晃; 野上英; 谷浩由輝; 中山智宏
神奈川県獣医師会第11回学術大会, Mar. 2024, Not invited - ニムスチンを用いた化学療法が奏功した原発性肺腫瘍の猫の一例
佐藤麗奈; 植田紗妃; 猪飼えり; 諸橋寧々; 石川智恵子; 後藤幸大; 坂井学; 谷浩由輝; 中山智宏
神奈川県獣医師会第11回学術大会, Mar. 2024, Not invited - Molecular Targeted Therapy for Canine and Feline Malignancies
Hiroyuki Tani
JCVIM Japan College of Veterinary Internal Medicine, Feb. 2024, Invited - Preventing Occupational Exposure to Anticancer Drugs in Veterinary Medicine
Hiroyuki Tani
JCVIM Japan College of Veterinary Internal Medicine, Feb. 2024, Invited - 臨床医が知っておきたい腫瘍内科治療－基本から最新知見までー
谷浩由輝
神奈川県獣医師会第40回卒後教育セミナー, Jan. 2023, Invited - 分子標的治療薬vs肥満細胞腫
谷 浩由輝
第25回日本獣医がん学会 メインシンポジウム 分子標的治療薬, Feb. 2022, Invited - 細胞診断学
谷 浩由輝
第25回日本獣医がん学会 総合教育講演：腫瘍の臨床診断と治療, Jan. 2022 - EFFECTS OF CO-ADMINISTRATION OF MOLECULAR TARGETDRUGS IN CANINE HISTIOCYTIC SARCOMA CELL LINES
Sakuma, Hiroki; Tani, Akiyoshi; Asada, Hajime; Goto-Koshino, Yuko; Tani, Hiroyuki; Ohno, Koichi; Tsujimoto, Hajime; Bonkobara, Makoto; Tomiyasu, Hirotaka
the 2021 Veterinary Cancer Society (VCS) Annual Conference, Nov. 2021 - SHP2阻害剤SHP099はSHP2 Glu76変異を有する犬組織球性肉腫に対して増殖抑制効果を示す
谷 浩由輝、栗田 晟那、宮本 良、落合 和彦、田村 恭一、盆子原 誠
第2回ニチジュウシンポジウム, Dec. 2019, Not invited - Expression and Genetic Variation of Apoptosis Inhibitor of Macrophage in Canine Histiocytic Sarcoma.
Uchida M; Uchida K; Tani H; Bonkobara M; Maeda S; Yonezawa T
ACVIM Forum 2019, Jun. 2019, Not invited - 犬組織球性肉腫細胞の増殖におけるPTPN11変異の役割に関する検討
谷 浩由輝; 栗田 晟那; 宮本 良; 田村 恭一; 盆子原 誠
第2回日本獣医がん分子生物学研究会, Sep. 2018, Not invited - The Surivine Inhibitor YM155 unduses Apoptotic Cell Death And Non-Apoptotic Cell Death In Canine Squamous Cell Carcinoma Cells.
Miyamoto R; Kurita S; Tani H; Ikeda I; Ishizuka M; Saima H; Kobayashi M; Tamura K; Bonkobara M
18th Biennial Congress of The International Society for Animal Clinical Pathology, Aug. 2018, Not invited - YM155 Inhibits the Growth of Canine Squamous Cell Carcinoma Cells with High Expression of Survivin.
Miyamoto R; Tani H; Kurita S; Ikeda T; Ishizaka M; Saima H; Tamura K; Bonkobara M
ACVIM Forum 2018, Jun. 2018, Not invited - Treatment of Histiocytic Sarcoma with Nimustine in Dogs: 9 Cases.
Tani H; Kurita S; Miyamoto R; Tamura K; Bonkobara M
ACVIM Forum 2018, Jun. 2018, Not invited - ACNU による補助療法で長期生存した犬組織球性肉腫の一症例
谷 浩由輝; 飯島 しずか; 栗田 晟那; 宮本 良; 安田 暁子; 盆子原 誠; 田村 恭一
第17回日本獣医がん学会, Jul. 2017, Not invited - 犬の悪性黒色腫4例に対するボルテゾミブの効果、日本獣医臨床病理学会
谷 浩由輝; 山本 仁美; 栗田 晟那; 宮本 良; 田村 恭一; 盆子原 誠
日本獣医臨床病理学会2016年大会, May 2016, Not invited - 精巣腫瘍の腹腔内転移に対して放射線治療を行った犬の2例
谷 浩由輝; 澤田 治美; 小野沢 栄里; 伊藤 秀俊; 高橋 賢一郎; 溝口 やよい; 南 智彦; 大崎 一朗; 宮本 三郎; 原田 慶; 藤田 道郎; 呰上 大吾
第14回日本獣医がん学会, Jan. 2016, Not invited - 外科的処置を実施した先天性第VII因子欠乏症のビーグルの1例
谷 浩由輝; 池田 美奈子; 下島 怜; 伊藤 秀俊; 南 智彦; 溝口 やよい; 髙橋 賢一郎; 呰上 大吾
日本獣医臨床病理学会2015年大会, May 2015, Not invited
