Miki Toshio
| Department of Medicine | Professor |
Researcher Information
Research Keyword
Field Of Study
Career
- Apr. 2019 - Present
日本大学医学部, 生体機能医学系生理学分野, 教授 - Jan. 2011 - Mar. 2019
University of Southern California, Stem Cell/Biochemistry/Surgery, Associate Professor - Apr. 1998 - Dec. 2010
University of Pittsburhgh, Transplant surgery/Pathology/Regenerative medicine, Postdoctoral fellow/assistant professor - Apr. 1992 - Mar. 1998
Nihon University School of Medicine, Surgery
Research activity information
Award
Paper
- The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma
Masahiro Ogawa; Mitsuhiko Moriyama; Yutaka Midorikawa; Hitomi Nakamura; Toshikatu Shibata; Kazumichi Kuroda; Hisashi Nakayama; Kazunori Kanemaru; Toshio Miki; Masahiko Sugitani; Tadatoshi Takayama
Journal of Clinical Biochemistry and Nutrition, 2023 - The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma
Mitsuhiko Moriyama; Tatsuo Kanda; Yutaka Midorikawa; Hiroshi Matsumura; Ryota Masuzaki; Hitomi Nakamura; Masahiro Ogawa; Shunichi Matsuoka; Toshikatu Shibata; Motomi Yamazaki; Kazumichi Kuroda; Hisashi Nakayama; Tokio Higaki; Kazunori Kanemaru; Toshio Miki; Masahiko Sugitani; Tadatoshi Takayama
Scientific Reports, Nov. 2022, Refereed, Not invited - Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria
Taiko I; Takano C; Nomoto M; Hayashida S; Kanemaru K; Miki T.
Scientific Reports, Nov. 2022, Refereed, Not invited
Last - Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells
Takano C; Horie M; Taiko I; Trinh QD; Kanemaru K; Komine-Aizawa S; Hayakawa S; Miki T.
Stem Cell Reviews and Reports, Aug. 2022, Refereed, Not invited
Last - Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest-derived multilineage cells.
Abe S; Kaida A; Kanemaru K; Nakazato K; Yokomizo N; Kobayashi Y; Miura M; Miki T; Hidai C; Kitano H; Yoda T.
Cell Proliferation, Jun. 2022, Refereed, Not invited - A case of breast squamous cell carcinoma,following breast augmentation with liquid,silicone injection after 16 years
Ryosuke Toyonaka; Jun Ozeki; Yumi Koyama; Saaya Takahashi; Xiaoyan Tang; Hiroko Kobayashi; Maki Amano; Keiichiro Tada; Toshio Miki; Mayumi Tani
Surgical Case Reports, Jan. 2022, Refereed, Not invited - Distribution of Amniotic Epithelial Cells After Intraportal Infusion in a Rat Model
Transplant Proc., Jan. 2022, Refereed, Not invited - Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges
Ibrahim Fathi; Toshio Miki
Front Med, Jan. 2022, Refereed, Invited
Corresponding - EGF domain peptide of Developmentally regulated endothelial locus1 facilitates gene expression of extracellularly applied plasmid DNA
Hisataka Kitano; Kazunori Kanemaru; Toshio Miki; Chiaki Hidai
Biological, Jan. 2022 - Clinical perspective on the use of human amniotic epithelial cells to treat congenital metabolic diseases with a focus on maple syrup urine disease
Chika Takano; Brendan H Grubbs; Mika Ishige; Erika Ogawa; Ichiro Morioka; Satoshi Hayakawa; Toshio Miki
Stem Cells Transl Med, Jun. 2021, Refereed, Not invited
Corresponding - Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency In Vivo
Hisataka Kitano; Yoh Masaoka; Atsushi Mamiya; Yusuke Fujiwara; Toshio Miki; Chiaki Hidai
In Vivo, Apr. 2021, Refereed, Not invited - Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells
Keiko Takagi; Yutaka Midorikawa; Tadatoshi Takayama; Hayato Abe; Kyoko Fujiwara; Masayoshi Soma; Hiroki Nagase; Toshio Miki; Noboru Fukuda
Molecules, 2020, Refereed, Not invited - An Epidermal Growth Factor Motif of Developmental Endothelial Locus 1 Protein Inhibits Efficient Angiogenesis in Explanted Squamous Cell Carcinoma In Vivo
Rev Invest Clin, 2020, Refereed, Not invited - Biological impact of xeno-free chemically defined cryopreservation medium on amniotic epithelial cells
Toshio Miki; Wisia Wong; Elton Zhou; Anthony Gonzalez; Irving Garcia; Brendan H. Grubbs
STEM CELL RESEARCH & THERAPY, Jan. 2016, Refereed, Not invited - Erratum: Human Induced Pluripotent Stem Cell-Derived Models to Investigate Human Cytomegalovirus Infection in Neural Cells (PLoS ONE (2014) 9:1 (DOI:10.1371/annotation/ea66e8f1-9f80-422f-8836-308a4cdc8ae4))
D{'}Aiuto L; Di Maio R; Heath B; Raimondi G; Milosevic J; Watson A.M; Bamne M; Parks W.T; Yang L; Lin B; Miki T; Mich-Basso J.D; Arav-Boger R; Sibille E; Sabunciyan S; Yolken R; Nimgaonkar V.
PLoS ONE, 2014, Refereed, Not invited - Human Induced Pluripotent Stem Cell-Derived Models to Investigate Human Cytomegalovirus Infection in Neural Cells
Leonardo D'Aiuto; Roberto Di Maio; Brianna Heath; Giorgio Raimondi; Jadranka Milosevic; Annie M. Watson; Mikhil Bamne; W. Tony Parks; Lei Yang; Bo Lin; Toshio Miki; Jocelyn Danielle Mich-Basso; Ravit Arav-Boger; Etienne Sibille; Sarven Sabunciyan; Robert Yolken; Vishwajit Nimgaonkar
PLOS ONE, Nov. 2012, Refereed, Not invited - Human Amniotic Epithelial Cells are Reprogrammed More Efficiently by Induced Pluripotency than Adult Fibroblasts
Charles A. Easley; Toshio Miki; Carlos A. Castro; John A. Ozolek; Crescenzio F. Minervini; Ahmi Ben-Yehudah; Gerald P. Schatten
CELLULAR REPROGRAMMING, Jun. 2012, Refereed, Not invited - Compartmental Hollow Fiber Capillary Membrane-Based Bioreactor Technology for In Vitro Studies on Red Blood Cell Lineage Direction of Hematopoietic Stem Cells
Greggory J. Housler; Toshio Miki; Eva Schmelzer; Christopher Pekor; Xiaokui Zhang; Lin Kang; Vanessa Voskinarian-Berse; Stewart Abbot; Katrin Zeilinger; Joerg C. Gerlach
TISSUE ENGINEERING PART C-METHODS, Feb. 2012, Refereed, Not invited - Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell-based therapy and case report on cell transplantation
Bruno Gridelli; Giovanni Vizzini; Giada Pietrosi; Angelo Luca; Marco Spada; Salvatore Gruttadauria; Davide Cintorino; Giandomenico Amico; Cinzia Chinnici; Toshio Miki; Eva Schmelzer; Pier Giulio Conaldi; Fabio Triolo; Joerg C. Gerlach
LIVER TRANSPLANTATION, Feb. 2012, Refereed, Not invited - Amnion-derived stem cells: in quest of clinical applications
Toshio Miki
STEM CELL RESEARCH & THERAPY, May 2011, Refereed, Not invited - Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells.
C. A. Easley; B. T. Phillips; J. M. Barringer; H. Valli; B. P. Hermann; C. R. Simerly; K. E. Orwig; G. P. Schatten
MOLECULAR BIOLOGY OF THE CELL, 2011, Refereed, Not invited - Continuous Analysis of Superoxide Production with Cypridina Luciferin Analogue: A Microdialysis Study
Miki T; Takahashi H; Takano S; Iwai S; Nakagawa S
J. Nihon Univ. Med., 1998, Refereed, Not invited
Lead
Lectures, oral presentations, etc.
- ミトコンドリアの細胞間水平移動と再生医療への新展望
三木敏生
第24回協和キリン腎臓シンポジウム, Nov. 2023, Invited - シングルセル解析を用いた ヒト羊膜上皮細胞の系統学的多様性の解明
高野智圭; 堀江真史; エルディーブ ダリア; 早川 智; 三木敏生
第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会, Nov. 2023 - Effect of human Amniotic Epithelial Cells on intraportal islet transplantation
Kaoru Okada; Kazuaki Tokodai; Miyako Tanaka; Tetsuro Hoshiai; Masatoshi Saito; Michiaki Unno; Toshio Miki; Takashi Kamei; Masafumi Goto
2023-IPITA-IXA-CTRMS, Oct. 2023 - Single-cell transcriptomes reveal phylogenetic diversification of human amniotic epithelial cells
Chika Takano; Masafumi Horie; Dahlia Eldeeb; Isamu Taiko; Toshio Miki
2023-IPITA-IXA-CTRMS, Oct. 2023 - Unlocking the Potential of Amniotic Epithelial Cells: Past Achievements and Future Prospects
Toshio Miki
2023-IPITA-IXA-CTRMS, Oct. 2023, Invited - 生体内イメージング技術によるマウス肝細胞のカルシウムダイナミクス解析
谷田部 一輝; 平岡 優一; 茂木 優貴; 三木 敏生; 飯野 正光; 金丸 和典
第30回 肝細胞研究会, Aug. 2023 - 細胞移植による肝臓の再生医療
三木敏生
日本消化器病学会, Jul. 2023, Invited - Mechanism of stemness maintenance in human amniotic epithelial cells
Chika Takano; Millei Kaga; Isamu Taiko; Yusuke Higuchi; Toshio Miki
The Physiological Society of Japan, Mar. 2023 - Directed differentiation of human amniotic epithelial cells to typeⅡ alveolar epithelial cells
Masayuki Nomoto; Isamu Taiko; Chika Takano; Kazunori Kanemaru; Toshio Miki
The Physiological Society of Japan, Mar. 2023, Not invited - ヒト胎盤由来幹細胞を用いた組織工学と再生医療の可能性
三木 敏生
第60回 日本人工臓器学会, Nov. 2022, 日本人工臓器学会, Invited - Expression of Traf2- and Nck-interacting kinase in EMT-inhibited human amniotic epithelial cells
Chika Takano; Toshio Miki
29th International Congress of The Transplantation Society, Sep. 2022, The Transplantation Society, Not invited - ヒト胎盤由来幹細胞を用いた先天性代謝異常症の細胞治療をめざして
三木 敏生
第 59 回日本小児外科学会学術集会, May 2022, 日本小児外科学会, Invited - Placental stem cell transplantation prevented disease development in ornithine transcarbamylase deficiency model mice
Toshio Miki
The Asia Pacific Association for the Study of the Liver, Oncology 2021, Dec. 2021, Invited - Placental stem cell-derived exosomal miR483-5p modulates hepatic stellate cell activation
The 27th Annual Meeting of the Japanese Society for the Research of Hepatic Cells, Dec. 2020, Japanese Society for the Research of Hepatic Cells, Invited - OTC欠損症モデルマウスを用いた羊膜上皮幹細胞移植の治療効果 の検討
第61回日本先天代謝異常学会総会 第17回アジア先天代謝異常症シンポジウム, Oct. 2019, Not invited - Placental Stem Cells and Their Clinical Applications
16th Congress of the Cell Transplant and Regenerative Society, Sep. 2019, Invited - Causative gene expressions of metabolic diseases on human amniotic epithelial cells
Chika Takano1,2, Naoto Kuki3,4, Yutaka Furuta5, Erika Ogawa1,6 , Mika Ishige1, Toshio Miki3
Affiliated academic society
Research Themes
- 細胞間ミトコンドリア移送開始シグナルの解明
日本学術振興会, 科学研究費助成事業, Jun. 2022 - Mar. 2025
三木 敏生; 太向 勇; 堀江 真史 - ブタを用いた羊膜上皮幹細胞の門脈内移植後体内動態及び機能評価
日本学術振興会, 令和4年度科学研究費助成事業, Apr. 2022 - Mar. 2025
淵本 大一郎; 大西 彰; 三角 浩司; 高野 智圭 - 羊膜由来幹細胞が肝内膵島生着環境に与える影響の解明
日本学術振興会, 科学研究費助成事業, Apr. 2022 - Mar. 2025
研究代表者:戸子台 和哲 - 先天代謝異常症に対する羊膜上皮細胞治療の開発
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2020 - Mar. 2023
研究代表者:高野 智圭 - 羊膜上皮細胞由来エクソソーマル miR483-5p による肝星細胞活性制御機 序の解明
Aug. 2019 - Mar. 2021 - GFP遺伝子導入ブタ羊膜上皮細胞の分離および性状分析
Dec. 2019 - Mar. 2020
大西 彰 生物資源科学部・教授
