KOBAYASHI Satomi

School of Dentistry Department of DentistryAssistant Professor

promotion

  • Profile (Promotion)

    神経科学, 島皮質/痛み/オプトジェネティクス法/行動実験/パッチクランプ法

Degree

  • D.D.S., Ph.D., Nihon University, Graduate School of Dentistry, Mar. 2024

Field Of Study

  • Life sciences, Neuroscience - general

Career

  • Apr. 2024 - Present
    日本大学歯学部, 基礎自然科学分野(生物学), 助教
  • Apr. 2020 - Mar. 2024
    日本大学歯学部, 基礎自然科学分野(生物学), 助手
  • Apr. 2016 - Mar. 2017
    日本大学歯学部付属歯科病院, 研修診療部

Educational Background

  • Apr. 2017 - Mar. 2024
    Nihon University, Graduate School of Dentistry, Department of Oral Structure and Function
  • Apr. 2010 - Mar. 2015
    Nihon University, School of Dentistry, Department of Dentistry

Award

  • Sep. 2026
    Japanese Association for Oral Biology, Academic encouragement award
    Regulation of nociception by long-term potentiation of inhibitory postsynaptic currents from insularcortical parvalbumin-immunopositive neurons to pyramidal neurons
  • Nov. 2024
    The 66th Annunal Meeting of Japanese Association for Oral Biology, モリタ優秀発表賞
    Regulation of nociception by specific activation of parvalbumin-immunopositive neurons in the insular cortex using chemical genetics
    S. Kobayashi;S. Fujita;M. Kobayashi
  • Jun. 2022
    第146回日本薬理学会関東部会, 優秀発表者賞
    光遺伝学的手法を用いた島皮質における疼痛制御機構の解明
    小林理美;藤田智史;小林真之

Paper

  • State-dependent neuronal activities of glutamatergic and GABAergic neurons in the rat insular cortex during a cue-guided lever manipulation task involving saccharin reward
    Risako Kato-Miyabe; Mie Kajiwara; Satomi Kobayashi; Masayuki Kobayashi
    Chemical Senses, Jul. 2026, Refereed
  • The cortical areas processing periodontal ligament nociception in mice
    Risako Okuma; Shutaro Kobayashi; Satomi Kobayashi; Yoshinori Arai; Naoyuki Matsumoto; Mitsuru Motoyoshi; Masayuki Kobayashi; Satoshi Fujita
    Journal of Oral Biosciences, Mar. 2025, Refereed
  • Regulation of nociception by long-term potentiation of inhibitory postsynaptic currents from insular cortical parvalbumin-immunopositive neurons to pyramidal neurons
    Satomi Kobayashi; Hironobu Osaki; Shigeki Kato; Kazuto Kobayashi; Masayuki Kobayashi
    Pain, Jan. 2025, Refereed
    Lead
  • Activation of multiple neuromodulatory systems in alert rats acquiring conditioned taste aversion revealed by positron emission tomography.
    Satomi Kobayashi; Mie Kajiwara; Yilong Cui; Takeo Sako; Tetsuya Sasabe; Emi Hayashinaka; Yasuhiro Wada; Masayuki Kobayashi
    Brain research, Jan. 2024, Refereed
    Lead
  • Insulin potentiates inhibitory synaptic currents between fast-spiking and pyramidal neurons in the rat insular cortex.
    Yuka Nakaya; Satoshi Kosukegawa; Satomi Kobayashi; Kensuke Hirose; Kouhei Kitano; Kotoe Mayahara; Hiroki Takei; Mitsuru Motoyoshi; Masayuki Kobayashi
    Neuropharmacology, Nov. 2023, Refereed
  • Insulin facilitates synaptic transmission via gap junctions between fast-spiking interneurons in the rat insular cortex.
    Satoshi Kosukegawa; Yuka Nakaya; Satomi Kobayashi; Kohei Kitano; Sachie Matsumura; Shohei Ogisawa; Manabu Zama; Mitsuru Motoyoshi; Masayuki Kobayashi
    Journal of oral science, Mar. 2023, Refereed
  • A new phenotype identification method with the fluorescent expression in cross-sectioned tails in Thy1-GCaMP6s transgenic mice.
    Shutaro Kobayashi; Kazunori O'Hashi; Keisuke Kaneko; Satomi Kobayashi; Shouhei Ogisawa; Morio Tonogi; Satoshi Fujita; Masayuki Kobayashi
    Journal of oral science, Apr. 2022, Refereed

MISC

  • Functional roles of descending projections from the cerebral cortex to the trigeminal spinal subnucleus caudalis in orofacial nociceptive information processing
    Masayuki Kobayashi; Yuka Nakaya; Satomi Kobayashi
    Journal of Oral Biosciences, May 2024

Lectures, oral presentations, etc.

  • 島皮質parvalbumin陽性細胞特異的活性化による疼痛制御
    小林理美; 藤田智史; 小林真之
    The 67th Annual Meeting of Japanese Association for Oral Biology, Sep. 2025
  • Suppression of nociception-related behavior by specific activation of parvalbumin-immunopositive neurons in the insular cortex using DREADD system
    Satomi Kobayashi; Hironobu Osaki; Satoshi Fujita; Shigeki Kato; Kayo Nishizawa; Kazuto Kobayashi; Masayuki Kobayashi
    The 48th Annual Meeting of the Japan Neuroscience Society, Jul. 2025, Not invited
  • マウスの大脳皮質における歯根膜感覚の情報処理
    大熊理沙子; 小林理美; 藤田智史; 本吉満
    第83回日本矯正歯科学会学術大会, Oct. 2024, Not invited
  • Regulation of nociception in orofacial area by long-term potentiation of inhibitory synapses in the insular cortex using optogenetics
    S. KOBAYASHI; H. OSAKI; S. FUJITA; S. KATO; K. KOBAYASHI; M. KOBAYASHI
    SOCIETY for NEUROSCIENCE, Oct. 2024, Not invited
  • Cortical responses to electrical stimulation of the periodontal ligament in mice
    R. OKUMA; S. KOBAYASHI; S. KOBAYASHI; Y. ARAI; M. KOBAYASHI; S. FUJITA
    SOCIETY for NEUROSCIENCE, Oct. 2024, Not invited
  • Activation of insular cortical projections to the parabrachial nucleus regulates pain-related behaviors in rats
    Y. NAKAYA; K. HIROSE; S. KOBAYASHI; H. OSAKI; M. KOBAYASHI
    SOCIETY for NEUROSCIENCE, Oct. 2024, Not invited
  • PKB/AKt pathway involves in facilitation of inhibitory synaptic transmission by insulin in the insular cortex
    Y. Nakaya; S. Kobayashi; K. Kitano; M.Kobayashi
    第97回日本薬理学会年会, Dec. 2023, Not invited
  • Induction of LTP of inhibitory synapses from parvalbumin-immunopositive neurons to pyramidal neurons using optogenetics
    S. Kobayashi; S. Fujita; M. Kobayashi
    第97回日本薬理学会年会, Dec. 2023, Not invited
  • インスリンはPI3K-PKB/AKtシグナル経路を介してラット島皮質抑制性シナプス伝達を促進する
    中谷 有香; 小林 理美; 廣瀬 健佑; 北野 晃平; 小林 真之
    第65回歯科基礎医学会学術大会, Sep. 2023, Not invited
  • 島皮質parvalbumin陽性細胞→錐体細胞シナプスにおける長期増強による疼痛コントロール
    小林 理美; 藤田 智史; 小林 真之
    第65回歯科基礎医学会学術大会, Sep. 2023
  • マウスの口腔顔面領域に対する温度刺激時の大脳皮質応答
    大熊 理沙子; 小林 理美; 藤田 智史; 小林 真之
    第65回歯科基礎医学会学術大会, Sep. 2023
  • Regulation of nociception by long-term potentiation of inhibitory synapses from parvalbumin-immunopositive neurons to pyramidal neurons in the insular cortex using optogenetics
    Satomi Kobayashi; Hironobu Osaki; Shigeki Kato; Kayo Nishizawa; Kazuto Kobayashi; Masayuki Kobayashi
    第46回日本神経科学大会, Aug. 2023
  • Regulation of pain by activation PV cells of insular cortex using optogenetics
    Satomi Kobayashi; Satoshi Fujita; Masayuki Kobayashi
    第64回歯科基礎医学会, Sep. 2022
  • 光遺伝学的手法を用いた島皮質における疼痛制御機構の解明
    小林理美,藤田智史,小林真之
    第146回日本薬理学会関東部会, Jun. 2022
  • Development of a method for LTP of inhibitory synapses by optogenetics
    Satomi Kobayashi; Kiyofumi Yamamoto; Satoshi Fujita; Masayuki Kobayashi
    第63回歯科基礎医学会, Oct. 2021

Courses

  • Apr. 2025 - Present
  • Sep. 2024 - Present
  • Apr. 2023 - Present
  • Apr. 2025 - Jul. 2025
  • Apr. 2025 - Jul. 2025
  • Sep. 2024 - Dec. 2024
  • Apr. 2021 - Jul. 2023
  • Sep. 2020 - Dec. 2022

Research Themes

  • 辛味嗜好性に島皮質-扁桃体回路が果たしている役割の検討
    Apr. 2026 - Mar. 2028
    小林理美
  • 鎮痛薬によってニューロン活動が変調する脳領域の解明
    日本学術振興会, 科学研究費助成事業, Apr. 2025 - Mar. 2028
    藤田 智史; 小林理美
  • アロディニアによる島皮質感覚応答ニューロンの可塑的変化の解明
    日本学術振興会, 科学研究費助成事業, Apr. 2026 - Mar. 2027
    小林 理美