KOBAYASHI SHUNSUKE
| Department of Pharmacy | Professor |
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Paper
- Effect of calcium ions on the aggregation of highly phosphorylated tau
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
Biochemistry and Biophysics Reports, Nov. 2024, Refereed, Not invited
Last - Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
Biochim Biophys Acta, Jul. 2022, Refereed
Last - 7-Hydorxyindirubin is capable of specifically inhibiting anticancer drug-induced YB-1 nuclear translocation without showing,cytotoxicity in HepG2 hepatocellular carcinoma cells
Toru Tanaka; Hiroaki Saito; Shinichi Miyairi; Shunsuke Kobayashi
Biochemical and Biophysical Research Communications, Mar. 2021, Refereed, Not invited
Last - Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation
Toru Tanaka; Sachiyo Ohashi; Akihiko Takashima; Shunsuke Kobayashi
Neurochemistry International, Oct. 2020, Refereed, Not invited
Last - Enhanced tau translation by hyper-excitation
Shunsuke Kobayashi; Toru Tanaka; Yoshiyuki Soeda; Akihiko Takashima
Front. Aging Neurosci., Nov. 2019, Refereed, Invited
Lead - Mechanism responsible for inhibitory effect of indirubin 3'-oxime on anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells
Toru Tanaka; Misaki Kasai; Shunsuke Kobayashi
Exp. Cell Res., Sep. 2018, Refereed, Not invited
Last - Indirubin 3′-oxime inhibits anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells
Toru Tanaka; Sachiyo Ohashi; Hiroaki Saito; Taira Wada; Tadashi Aoyama; Yoshimi Ichimaru; Shinichi Miyairi; Shunsuke Kobayashi
Biochemical and Biophysical Research Communications, Jan. 2018, Refereed, Not invited
Last - Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells
Yasuhiro Kosuge; Hiroaki Saito; Tatsuki Haraguchi; Yoshimi Ichimaru; Sachiyo Ohashi; Hiroko Miyagishi; Shunsuke Kobayashi; Kumiko Ishige; Shinichi Miyairi; Yoshihisa Ito
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Dec. 2017, Refereed, Not invited - Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation
Shunsuke Kobayashi; Toru Tanaka; Yoshiyuki Soeda; Osborne F. X. Almeida; Akihiko Takashima
EBIOMEDICINE, Jun. 2017, Refereed, Not invited
Lead - Four nucleocytoplasmic-shuttling proteins and p53 interact specifically with the YB-NLS and are involved in anticancer reagentinduced nuclear localization of YB-1
Toru Tanaka; Sachiyo Ohashi; Shunsuke Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2016, Refereed, Not invited
Corresponding - YB-1 gene expression is kept constant during myocyte differentiation through replacement of different transcription factors and then falls gradually under the control of neural activity
Shunsuke Kobayashi; Toru Tanaka; Masamitsu Moue; Sachiyo Ohashi; Taishi Nishikawa
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Nov. 2015, Refereed, Not invited
Lead - Indirubin derivatives alter DNA binding activity of the transcription factor NF-Y and inhibit MDR1 gene promoter
Toru Tanaka; Sachiyo Ohashi; Hiroaki Saito; Takashi Higuchi; Keiichi Tabata; Yasuhiro Kosuge; Takashi Suzuki; Shinichi Miyairi; Shunsuke Kobayashi
EUROPEAN JOURNAL OF PHARMACOLOGY, Oct. 2014, Refereed, Not invited
Corresponding - Roles of YB-1 under arsenite-induced stress: translational activation of HSP70 mRNA and control of the number of stress granules
Tanaka T; Ohashi S; Kobayashi S.
Biochimica et Biophysica Acta, Mar. 2013, Refereed, Not invited
Corresponding - Mechanism of YB-1-mediated translational induction of GluR2 mRNA in response to neural activity through nAChR
Toru Tanaka; Sachiyo Ohashi; Masamitsu Moue; Shunsuke Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jul. 2012, Refereed, Not invited
Corresponding - Translational level of acetylcholine receptor α mRNA in mouse skeletal muscle is regulated by YB-1 in response to neural activity
Sachiyo Ohashi; Masamitsu Moue; Toru Tanaka; Shunsuke Kobayashi
Biochem.Biophys.Res.Commun., Nov. 2011, Refereed, Not invited
Corresponding - YB-1 binds to Glu2 mRNA and CaM1 mRNA in the brain and regulates their translational levels in an acitivity-dependent manner
Tanaka T; Ohashi S; Funakoshi T; Kobayashi S.
Cellular and Molecular Neurobiology, Oct. 2010, Refereed, Not invited
Corresponding - HSP60 interacts with YB-1 and affects its polysome association and subcellular localization.
Ohashi S; Atsumi M; Kobayashi S.
Biochem.Biophys.Res.Commun., Aug. 2009, Refereed, Not invited
Corresponding - YB-1 transcription in the postnatal brain is regulated by a bHLH transcription factor Math2 through an E-box sequence in the 5′-UTR of the gene
Sachiyo Ohashi; Reiko Fukumura; Takashi Higuchi; Shunsuke Kobayashi
Molecular and Cellular Biochemistry, Jul. 2009, Refereed, Not invited
Corresponding - U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y
Takashi Higuchi; Kaijiro Anzai; Shunsuke Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Feb. 2008, Refereed, Not invited
Corresponding - Expression and polysome association of YB-1 in various tissues at different stages in the lifespan of mice
Arisa Miwa; Takashi Higuchi; Shunsuke Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Nov. 2006, Refereed, Not invited
Corresponding - Application of the BC1 RNA gene promoter for short hairpin RNA expression in cultured neuronal cells.
Shunsuke Kobayashi; Takashi Higuchi; Kaijiro Anzai
Biochem.Biophys.Res.Commun., Sep. 2005, Refereed, Not invited
Lead - Recent evolutionary origin within the primate lineage of two pseudogenes with similarity to members of the transforming growth factor-beta superfamily
Eketjall S; Jornvall H; Lonnerberg P; Kobayashi S; Ibanez CF.
Cellular and Molecular Life Sciences, Feb. 2004, Refereed, Not invited - Isolation and characterization of brain Y-box protein: developmentally regulated expression, polyribosomal association and dendritic localization
T Funakoshi; S Kobayashi; S Ohashi; TA Sato; K Anzai
MOLECULAR BRAIN RESEARCH, Oct. 2003, Refereed, Not invited
Corresponding - Positive and negative regulators for neuronal BC1 RNA transcription by RNA polymerase III are possible members of the RNA polymerase II transcription system
S Kobayashi; S Kamo; K Agui; T Funakoshi; K Anzai
MOLECULAR BRAIN RESEARCH, Mar. 2003, Refereed, Not invited
Lead - Identification of mRNA/protein (mRNP) complexes containing Pur alpha, mStaufen, Fragile X Protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor
S Ohashi; K Koike; A Omori; S Ichinose; S Ohara; S Kobayashi; TA Sato; K Anzai
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Refereed, Not invited - Pur alpha protein implicated in dendritic RNA transport interacts with ribosomes in neuronal cytoplasm
YM Li; K Koike; S Ohashi; T Funakoshi; M Tadano; S Kobayashi; K Anzai; N Shibata; M Kobayashi
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2001, Refereed, Not invited - The single-stranded DNA- and RNA-binding proteins pur alpha and pur beta link BC1 RNA to microtubules through binding to the dendrite-targeting RNA motifs
S Ohashi; S Kobayashi; K Omori; T Ohara; A Omae; T Muramatsu; YM Li; K Anzai
JOURNAL OF NEUROCHEMISTRY, Nov. 2000, Refereed, Not invited - Neural BC1 RNA associates with Pur alpha, a single-stranded DNA and RNA binding protein, which is involved in the transcription of the BC1 RNA gene
S Kobayashi; K Agui; S Kamo; YM Li; K Anzai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2000, Refereed, Not invited
Lead - Identification of a negative regulatory DNA element from neuronal BC1 RNA expression by RNA polymerase Ⅲ
Kobayashi S; Kamo S; Ohmae A; Agui K; Li Y; Anzai K.
Biochimica et Biophysica Acta, Sep. 2000, Refereed, Not invited
Lead - The dendritic translocation of translin protein in the form of BC1 RNA protein particles in developing rat hippocampal neurons in primary culture
S Kobayashi; A Takashima; K Anzai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1998, Refereed, Not invited
Lead - An E-box sequence acts as a transcriptional activator for BC1 RNA expression by RNA polymerase III in the brain
S Kobayashi; K Anzai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 1998, Refereed, Not invited
Lead - Mutational analysis reveals that an array of GCAAG/CTTGC motifs between sprit promoter sequences for RNA polymerase III is essential for neural BC1 RNA transcription
S Kobayashi; K Anzai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 1997, Refereed, Not invited
Lead - Neural BC1 RNA in mouse skeletal muscle is a denervation-induced RNA whose expression is developmentally regulated
K Anzai; S Kobayashi; H Kotake; H Murakami; K Korematsu; Nonaka, I
NEUROSCIENCE LETTERS, Sep. 1996, Refereed, Not invited - IDENTIFICATION OF THE 23 KDA SUBUNIT OF TAU-PROTEIN KINASE-II AS A PUTATIVE ACTIVATOR OF CDK5 IN BOVINE BRAIN
K ISHIGURO; S KOBAYASHI; A OMORI; M TAKAMATSU; S YONEKURA; K ANZAI; K IMAHORI; T UCHIDA
FEBS LETTERS, Apr. 1994, Refereed, Not invited - A CDC2-RELATED KINASE PSSALRE/CDK5 IS HOMOLOGOUS WITH THE 30 KDA SUBUNIT OF TAU-PROTEIN KINASE-II, A PROLINE-DIRECTED PROTEIN-KINASE ASSOCIATED WITH MICROTUBULE
S KOBAYASHI; K ISHIGURO; A OMORI; M TAKAMATSU; M ARIOKA; K IMAHORI; T UCHIDA
FEBS LETTERS, Dec. 1993, Refereed, Not invited
Lead - GLYCOGEN-SYNTHASE KINASE 3-BETA IS IDENTICAL TO TAU-PROTEIN KINASE-I GENERATING SEVERAL EPITOPES OF PAIRED HELICAL FILAMENTS
K ISHIGURO; A SHIRATSUCHI; S SATO; A OMORI; M ARIOKA; S KOBAYASHI; T UCHIDA; K IMAHORI
FEBS LETTERS, Jul. 1993, Refereed, Not invited - Developmental change in subcellular location of Bp-1 protein with an ability to interact with both identifier sequence and its brain-specific transcript, BC-1 RNA.
Kobayashi S; Tokuno T; Suzuki K; Higashi N; Goto S; Anzai K.
Biochemical and Biophysical Research Communications, Nov. 1992, Refereed, Not invited
Lead - THE 10-S BC-1 RIBONUCLEOPROTEIN PARTICLE CONTAINS IDENTIFIER SEQUENCE-BINDING PROTEINS THAT INTERACT WITH AN ARRAY OF GCAAG/CTTGC MOTIFS BETWEEN SPLIT PROMOTER SEQUENCES FOR RNA POLYMERASE-III
S KOBAYASHI; N HIGASHI; K SUZUKI; S GOTO; K YUMOTO; K ANZAI
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1992, Refereed, Not invited
Lead - BRAIN-SPECIFIC SMALL RNA TRANSCRIPT OF THE IDENTIFIER SEQUENCES IS PRESENT AS A 10-S RIBONUCLEOPROTEIN PARTICLE
S KOBAYASHI; S GOTO; K ANZAI
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1991, Refereed, Not invited
Lead - SPECIFIC-INHIBITION OF INSOLUBLE GLUCAN SYNTHASE (GTF-I) BY MAILLARD REACTION-PRODUCTS FROM CASEIN AND ALBUMINS
S KOBAYASHI; K KOGA; O HAYASHIDA; Y NAKANO; Y HASEGAWA
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Oct. 1990, Refereed, Not invited
Lead - GLUCAN-BINDING DOMAIN OF A GLUCOSYLTRANSFERASE FROM STREPTOCOCCUS-SOBRINUS - ISOLATION OF A 55-KILODALTON PEPTIDE FROM A TRYPSIN DIGEST OF GLUCOSYLTRANSFERASE PREBOUND TO INSOLUBLE GLUCAN
S KOBAYASHI; K KOGA; O HAYASHIDA; Y NAKANO; Y HASEGAWA
INFECTION AND IMMUNITY, Jul. 1989, Refereed, Not invited
Lead - INHIBITORY EFFECTS OF MAILLARD REACTION-PRODUCTS ON GLUCOSYL-TRANSFERASE OF STREPTOCOCCUS-MUTANS
S KOBAYASHI; K KOGA; O HAYASHIDA; Y NAKANO; Y HASEGAWA
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jun. 1988, Refereed, Not invited
Lead - Nucleotide sequence of mouse genomic DNA coding for a brain specific small RNA.
Kobayashi S; Anzai K; Goto S.
Nucleic Acids Research, Jan. 1988, Refereed, Not invited
Lead - Conservation of the ID sequence and its expression as small RNA in rodent brains: analysis with cDNA for mouse brain-specific small RNA.
Anzai K; Kobayashi S; Suehiro Y; Goto S.
Brain Research, Oct. 1987, Refereed, Not invited - ISOLATION AND SEQUENCING OF A GENOMIC CLONE FOR MOUSE-BRAIN SPECIFIC SMALL RNA
K ANZAI; S KOBAYASHI; N KITAMURA; Y KANAI; H NAKAJIMA; Y SUEHIRO; S GOTO
JOURNAL OF NEUROCHEMISTRY, Sep. 1986, Refereed, Not invited
Lectures, oral presentations, etc.
- カルシウムイオンが引き起こす高リン酸化Tauの凝集
第47回日本分子生物学会年会, Nov. 2024, Not invited - 高リン酸化Tauの凝集におけるカルシウムイオンの影響
日本薬学会第144年会, Mar. 2024, Not invited - KANSL1 mRNAの新奇3'-UTRバリアントはtau mRNAに相補的な領域を持ち翻訳を活性化する
第46回日本分子生物学会年会, Dec. 2023, Not invited - 樹状突起におけるTauの局所翻訳と過剰リン酸化
日本薬学会第143年会, Mar. 2023, 日本薬学会, Not invited - Tauの過剰リン酸化に関わるCDK5の樹状突起発現機構と活性化機構
第45回日本分子生物学会年会, Dec. 2022, 日本分子生物学会, Not invited - がんの増悪を引き起こすYB-1タンパク質の核移行を特異的に阻害するindirubin誘導体の効果と核移行阻害メカニズム
日本薬学会第142回年会, Mar. 2022, Not invited - tau mRNAに相補的なKANSL1 mRNAの新奇スプライスバリアントの解析
第44回日本分子生物学会, Dec. 2021, 日本分子生物学会, Not invited - YB-1核移行を特異的に阻害するがん増悪抑制薬の探索
日本薬学会第141回年会, Mar. 2021, 日本薬学会, Not invited - グルタミン酸刺激に応じた樹状突起GSK3βの活性化とタウの過剰リン酸化
第43回日本分子生物学会, Dec. 2020, 日本分子生物学会, Not invited - 3次元ヒト鼻腔透明モデルを用いた温度感受性in situゲル剤の鼻腔内滞留性の定量的評価法の開発
日本薬学会関東支部大会, Sep. 2020, 日本薬学会関東支部会, Not invited - 肝臓におけるYB-1のポリソーム結合性に影響を与える新奇lncRNA
第93回日本生化学会, Sep. 2020, Not invited - YB-1の核移行を標的としたがんの増悪抑制
田中融、小林俊亮
日本薬学会第140年会, Mar. 2020, 日本薬学会, Not invited - 刺激に応じた樹状突起内GSK3βの活性化
第42回日本分子生物学会, Dec. 2019, 日本分子生物学会, Not invited - がんの増悪に関わるYB-1核移行阻害物質
第92回日本生化学会年会, Sep. 2019, Not invited - 刺激に応じた神経突起内GSK3β mRNAの翻訳活性化とタウのリン酸化
日本薬学会第139年会, Mar. 2019, Not invited - 抗がん剤誘発YB-1核移行を阻害するbis-indole化合物の作用機構
第41回日本分子生物学会年会, Nov. 2018, 日本分子生物学会, Not invited - がんの増悪を引き起こすYB-1の核移行を阻害する化合物
日本薬学会, Mar. 2018, Not invited - タウタンパク質の生理機能と認知症における役割
2017年度生命科学系学会合同年次大会(ConBio2017), Dec. 2017, Invited - タウmRNAの樹状突起内分布と刺激に応じた局所翻訳およびリン酸化
2017年度生命科学系学会合同年次大会(ConBio2017), Dec. 2017, Not invited - Local somatodendritic translation of tau protein triggered by AMPA and NMDA receptor stimulation.
Neuroscience 2017, Nov. 2017, Not invited - 刺激に応じたタウmRNAの樹状突起内翻訳とリン酸化
小林俊亮
タウ研究会2017, Aug. 2017, タウ研究会, Invited - 腫瘍細胞におけるYB-1の細胞内分布に関わる配列(YB-NLS)とその結合タンパク質の解析
日本薬学会, Mar. 2017, Not invited - がんの増悪を引き起こすYB-1の核移行に関連する因子の解析
田中融、大橋祥世、小林俊亮
日本分子生物学会, Dec. 2016, Not invited - がん悪性化を誘発するYB-1タンパク質の核内蓄積に関わる因子の解析
日本薬学会第136年会, Mar. 2016, Not invited - YB-1遺伝子発現は骨格筋の分化過程で転写因子の交代によって一定に保たれ、その後神経支配下に移行する
日本生化学会・日本分子生物学会 合同年会, Dec. 2015, 日本生化学会 日本分子生物学会, Not invited - Stress granuleの形成と解除におけるYB-1の役割
都築竜太、田中融、大橋祥世、小林俊亮
日本薬学会関東支部大会, Sep. 2015, Not invited - がん増悪因子YB-1の核移行輸送タンパク質の探索
日本薬学会, Mar. 2015, Not invited - 転写因子NF-YのDNA結合性を変化させMDR1遺伝子プロモーターを阻害するIndirubin誘導体
日本分子生物学会, Nov. 2014, Not invited - YB-1の核移行シグナルと相互作用するタンパク質の解析
日本生化学会, Oct. 2014, Not invited - 亜ヒ酸ストレス下での翻訳調節因子YB-1の役割
田中融、大橋祥世、小林俊亮
日本薬学会, Mar. 2014, 日本薬学会, Not invited - Asによるストレスを受けた細胞中でのYB-1による翻訳調節
日本分子生物学会, Dec. 2013, Not invited - タウmRNA輸送
小林俊亮
タウ研究ミーティング, Aug. 2013, 国立長寿医療研究センター, Invited - 肝由来の細胞におけるYB-1遺伝子の転写とYB-1タンパク質による糖代謝関連酵素の翻訳調節
日本薬学会, Mar. 2013, Not invited - RNA結合タンパク質YB-1によるエネルギー代謝関連酵素の翻訳調節
日本分子生物学会, Dec. 2012, Not invited - Indirubin誘導体によるNF-Y活性を介したMDR1遺伝子の発現抑制
日本分子生物学会, Dec. 2012, Not invited - MDR1遺伝子の発現を抑制するIndirubin誘導体の解析
日本薬学会, Mar. 2012, Not invited - Mechanism of YB-1-mediated translational induction of GluR2 mRNA in response to neural activity through nAChR
田中融、大橋祥世、馬上雅光、小林俊亮
The 34th annual meeting of the molecular biology sociaty of Japan, Dec. 2011, 日本分子生物学会, Not invited - 骨格筋のAChR α mRNAは神経活動に応じてYB-1による翻訳調節を受ける
日本生化学会, Sep. 2011, Not invited - YB-1による骨格筋AChR α mRNAの翻訳調節
日本薬学会, Mar. 2011, Not invited - YB-1による骨格筋組織におけるnAchRα mRNAの翻訳調節
日本分子生物学会年会・日本生化学会大会合同大会, Dec. 2010, 日本, Not invited - YB-1による神経活性依存的なGluR2 mRNAの翻訳調節におけるHSP60の関与
日本分子生物学会年会・日本生化学会大会合同大会, Dec. 2010, Not invited - 翻訳調節因子YB-1の骨格筋細胞における転写調節機構の解析
西川泰史、馬上雅光、田中融、大橋祥世
日本薬学会, Mar. 2010, Not invited - 転写因子NF-YのDNA結合性に影響を与えるIndirubin関連化合物によるMDR1遺伝子発現の抑制
田中融、大橋祥世、樋口孝、斉藤弘明、宮入伸一
日本薬学会, Mar. 2010, Not invited - HSP60がYB-1のポリソーム結合性と翻訳調節に与える影響
大橋祥世、厚見恵、田中融
日本薬学会, Mar. 2010, Not invited - 神経活動にともなう翻訳反応におけるYB-1タンパク質の影響
日本分子生物学会, Dec. 2009, Not invited - YB-1のポリソーム結合性と細胞内局在の調節に関わるタンパク質
日本生化学会, Oct. 2009, Not invited - 成長過程の脳におけるYB-1遺伝子発現の調節
大橋祥世、樋口孝、小林俊亮、安西偕二郎
日本薬学会, Mar. 2009, Not invited - 脳においてYB-1タンパク質が相互作用するmRNA
田中融、大橋祥世、小林俊亮、安西偕二郎
日本薬学会, Mar. 2009, Not invited - GluR2 mRNAの翻訳に対するYB-1タンパク質の影響
日本分子生物学会, 2008, Not invited - 細胞質におけるHSP60とYB-1の相互作用
日本分子生物学会, 2008, Not invited - 転写因子NF-YのDNA結合性を抑制するU7 snRNAの新しい機能
樋口孝、小林俊亮、安西偕二郎
日本分子生物学会・日本生化学会合同年会, Dec. 2007, Not invited - 発達過程の脳におけるYB-1遺伝子の転写調節
日本薬学会, 2007, Not invited - マウスの成長過程におけるY-boxタンパク質の組織特異的な発現とPolysome結合性
日本薬学会, Mar. 2006, Not invited - Activity of the inverted CCAAT sequence-binding protein factors YB-1 and NF-Y is affected by nuclear RNA in MDR1 gene transcription.
The 20th IUBMB Congress and 11th FAOBMB Congress., 2006, Not invited - 脳におけるYB-1遺伝子の転写調節機構
日本分子生物学会2006フォーラム, 2006, Not invited - 転写因子NF-YのDNA結合性に影響を及すRNA配列の解析
日本分子生物学会, Dec. 2005, Not invited - 脳におけるY-boxタンパク質の神経活動によるpolysome結合性の変化
日本分子生物学会, Dec. 2005, Not invited - 神経選択的にPol IIIで転写されるBC1 RNA遺伝子のプロモーターを利用したRNA干渉
日本分子生物学会, Dec. 2005, Not invited - 核内RNAが神経系腫瘍細胞のMDR1遺伝子プロモーターに与える抑制的効果
樋口孝、小林俊亮、安西偕二郎
日本薬学会, Mar. 2005, Not invited - Inhibitory effect of nuclear RNA molecules on the MDR1 promoter activity in neuroblastoma cells.
樋口孝、小林俊亮、安西偕ニ郎
日本生化学会, 2004, Not invited - マウスの成長過程におけるY-boxタンパクの組織特異的な発現とpolysome結合性
三輪亜梨紗
日本分子生物学会, 2004, Not invited - 神経系腫瘍細胞のY-box蛋白質とNF-YのDNA結合活性に及すRNA の影響
日本分子生物学会, 2003 - A brain Y-box protein is associated with polyribosomes and distributed in the dendrites of neurons.
日本生化学会, 2003, Not invited - 神経系腫瘍細胞のY-box蛋白質とNF-YのDNA結合活性に及すRNAの影響
日本分子生物学会, 2003, Not invited - ラット脳Y-box蛋白質のcDNAの単離
日本生化学会, 2002, Not invited - Identification of mRNP complexes containing pur alpha, mStaufen, fragile X protein and myosin Va, and their association with rough endoplasmic reticulum equipped with a kinesin mopter.
日本分子生物学会, 2002, Not invited - 神経特異的なPol III転写産物(BC1 RNA)の転写を調節する因子のPol II系遺伝子発現への関与
日本分子生物学会, 2002, Not invited - Pur alphaタンパクによる神経細胞樹状突起へのRNA輸送
日本RNA学会, 2001, Not invited - Recent evolutionary origin within the primate lineage of two new members of the TGF-beta gene superfamily specifically expressed in the nervous system
Annual Meeting Society for Neuroscience, 2001, Not invited - 神経選択的なPol III転写産物、BC1 RNAの転写へのPur alphaタンパクの関与
日本分子生物学会, 2000, Not invited - Pur alpha, pur betaタンパクと樹状突起RNA輸送
日本分子生物学会, 2000, Not invited - 神経細胞におけるRNAの輸送に関与するタンパクの解析
日本薬学会関東支部大会, 2000, Not invited - 神経選択的なPol III系遺伝子の転写を調節する因子の解析
日本生化学会, 1999, Not invited - 樹状突起に分布するBC1 RNAに結合するTranslinタンパクの細胞内局在
日本分子生物学会, 1999, Not invited - 神経系に特異的なPol III系遺伝子BC1 RNA geneの転写調節機構
日本生化学会, 1998, Not invited - 神経選択的なPol III系遺伝子の発現を負に制御する因子の解析
日本分子生物学会, 1998, Not invited - 神経特異的低分子RNAの発現調節機構
日本薬学会関東支部大会, 1997, Not invited - 神経系に特異的なBC1 RNAの発現におけるCAATTG配列の関与
日本分子生物学会, 1997, Not invited - BC1 RNPに含まれるDNA/RNA結合タンパクの解析
日本生化学会、日本分子生物学会合同年会, 1996, Not invited - 種に特異的なSINE遺伝子の神経系における発現
日本生化学会, 1995, Not invited - タウプロテインキナーゼIIの2種のサブユニットの解析
日本生化学会, 1994, Not invited - 骨格筋組織におけるBC1 RNAの発現
日本生化学会, 1994, Not invited - タウプロテインキナーゼIIのidentity
日本分子生物学会, Dec. 1993, Not invited - タウプロテインキナーゼとGSK3βの同一性
日本生化学会, Oct. 1993, Not invited - BC-1 RNPに含まれるID配列結合タンパク質の解析
日本生化学会, Oct. 1992, Not invited - BC-1 RNPに含まれるID配列結合蛋白質
日本生化学会, Oct. 1990, Not invited - カゼインーデキストラン結合体による不溶性グルカン合成酵素の特異的阻害
日本農芸化学会, Sep. 1990, Not invited - BC-1 RNA-protein complexの解析
日本薬学会, Mar. 1990, Not invited - Streptococcuc sobrinus B13のglucosyltransferaseのglucan binding domain.
日本農芸化学会, Sep. 1989, Not invited - Streptococcus mutansのグルカン合成酵素を阻害するメイラード反応生成物
日本農芸化学会, Sep. 1989, Not invited - マウス脳特異的低分子量RNAをコードした遺伝子とその発現
日本生化学会, Oct. 1985, Not invited
Research Themes
- 鼻から脳への薬物移行経路を介した経鼻投与製剤の基盤技術の開発と中枢疾患治療戦略
Apr. 2019 - Mar. 2021 - YB-1タンパク質とAhRを分子標的としたインディルビン誘導体によるがんの悪性化阻害
Mar. 2014 - Apr. 2016 - 認知症治療薬を目指した抗タウオパチー薬の創出およびタウ新規機能に基づく標的分子の設定
Apr. 2013 - Mar. 2016 - Indirubin誘導体を用いたYB-1の核移行阻害によるがんの悪性化の抑制
Apr. 2013 - Mar. 2014 - Preraration and characterization of novel bioactive substances in anlogy to indhirubin
Apr. 2010 - Mar. 2012 - 神経系におけるYB-1遺伝子の転写調節機構とターゲットmＲＮＡに関する研究
Apr. 2007 - Mar. 2008 - 神経系遺伝子の発現を制御する新規サイレンサータンパク質の解析
Apr. 2004 - Mar. 2005 - 神経系におけるＹ－ｂｏｘ蛋白質の多機能性の解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2003 - Mar. 2005
KOBAYASHI Shunsuke; FUNAKOSHI Tomoko - トランスリンの神経細胞におけるＢＣ１ＲＮＡ輸送と樹状突起内タンパク合成への関与
Apr. 1999 - Mar. 2001 - シナプスに局在する低分子量ＲＮＡに関する研究
Apr. 1995 - Mar. 1996 - ニューロンの樹状突起にあるＢＣ－１ＲＮＡの転写とその調節機構
日本学術振興会, 科学研究費助成事業, Apr. 1994 - Mar. 1995
小林 俊亮
