Ph.D., The University of Osaka, Mar. 2001

chromatin

importinα

核-細胞質間分子輸送

情報伝達制御

初期胚発生

細胞分化

imortin α

胚発生

核-細胞質間蛋白質輸送

Life sciences, Molecular biology

Life sciences, Developmental biology

Life sciences, Cell biology

Apr. 2024 - Present
日本大学, 文理学部生命科学科, 教授

Apr. 2016 - Mar. 2024
Nihon University, 文理学部生命科学科, Associate professor

Apr. 2014 - Mar. 2016
国立研究開発法人 医薬基盤・健康・栄養研究所, 研究員

Apr. 2001 - Mar. 2014
Osaka University, 医学(系)研究科(研究院), 助教、研究員

★Single-molecule microscopy reveals that importin α slides along DNA while transporting cargo molecules.
Trishit Banerjee; Kazuya Jibiki; Hinata Sugasawa; Saori Kanbayashi; Taiki Niikura; Eriko Mano; Shigeru Chaen; Takashi S Kodama; Satoshi Takahashi; Noriko Yasuhara; Kiyoto Kamagata
Biochemical and biophysical research communications, Feb. 2025, Refereed
Corresponding

★Biochemical propensity mapping for structural and functional anatomy of importin α IBB domain
Kazuya Jibiki; Mo-yan Liu; Chao-sen Lei; Takashi S. Kodama; Chojiro Kojima; Toshimichi Fujiwara; Noriko Yasuhara
Genes to Cells, Dec. 2021, Refereed, Not invited
Corresponding

★Importin α2 association with chromatin: Direct DNA binding via a novel DNA‐binding domain
Kazuya Jibiki; Takashi S. Kodama; Atsushi Suenaga; Yota Kawase; Noriko Shibazaki; Shin Nomoto; Seiya Nagasawa; Misaki Nagashima; Shieri Shimodan; Renan Kikuchi; Mina Okayasu; Ruka Takashita; Rashid Mehmood; Noriko Saitoh; Yoshihiro Yoneda; Ken‐ichi Akagi; Noriko Yasuhara
Genes to Cells, Sep. 2021, Refereed, Not invited
Corresponding

Plexin Domain Containing 2, a Protein Specifically Expressed and Elevated in Human Pancreatic Cancer Tissue and Serum, Influences Cell Proliferation by Correlating With Cortactin.
Junya Tsuboi; Akiko Eguchi; Hiroyuki Inoue; Masako Ichishi; Masatomo Go; Ryo Okajima; Noriko Yasuhara; Ryo Nakagawa; Mina Tempaku; Kiyora Izuoka; Takamitsu Tanaka; Kenji Nose; Naohiko Yoshizawa; Yoshifumi Hirokawa; Reiko Yamada; Kyosuke Tanaka; Takeshi Kawamura; Tetsuji Yamaguchi; Yoshiyuki Takei; Motoh Iwasa; Takefumi Yamashita; Masatoshi Watanabe; Hayato Nakagawa
Cancer medicine, Dec. 2025

Integrative Molecular Analysis of DNA Methylation Dynamics Unveils Molecules with Prognostic Potential in Breast Cancer
Rashid Mehmood; Alanoud Alsaleh; Muzamil Y. Want; Ijaz Ahmad; Sami Siraj; Muhammad Ishtiaq; Faizah A. Alshehri; Muhammad Naseem; Noriko Yasuhara
BioMedInformatics, Jun. 2023

Importin alpha family NAAT/IBB domain: Functions of a pleiotropic long chameleon sequence
Kazuya Jibiki; Takashi S. Kodama; Noriko Yasuhara
Advances in Protein Chemistry and Structural Biology, Jan. 2023
Last

Systems genomics of nucleoporins provides prognostic insights into breast cancer
Rashid Mehmood; Kazuya Jibiki; Zakeya J. Alsafwani; Muhammad Naseem; Noriko Yasuhara
Advancements in Life Science, May 2022, Refereed, Not invited
Last

Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer.
Mehmood R; Jibiki K; Shibazaki N; Yasuhara N.
Heliyon, Jan. 2021, Refereed, Not invited
Last

Importins in the maintenance and lineage commitment of ES cells.
Noriko Yasuhara; Yoshihiro Yoneda.
Neurochem Int., May 2017, Refereed, Invited
Lead

Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport.
Yasuhara N; Kumar PK.
Journal of Biochemistry, Nov. 2016, Refereed, Not invited
Lead

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells.
Umemura Y; Koike N; Matsumoto T; Yoo SH; Chen Z; Yasuhara N; Takahashi JS; Yagita K.
Proc Natl Acad Sci U S A., Nov. 2014, Refereed, Not invited

Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta
Saehae Choi; Eiki Yamashita; Noriko Yasuhara; Jinsue Song; Se-Young Son; Young Han Won; Hye Rim Hong; Yoon Sik Shin; Toshihiro Sekimoto; Il Yeong Park; Yoshihiro Yoneda; Soo Jae Lee
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Apr. 2014, Refereed, Not invited

Importin Alpha Subtypes Determine Differential Transcription Factor Localization in Embryonic Stem Cells Maintenance
Noriko Yasuhara; Ryosuke Yamagishi; Yoshiyuki Arai; Rashid Mehmood; Chihiro Kimoto; Toshiharu Fujita; Kenichi Touma; Azumi Kaneko; Yasunao Kamikawa; Tetsuji Moriyama; Toshio Yanagida; Hiroki Kaneko; Yoshihiro Yoneda
Developmental Cell, Jul. 2013, Refereed, Not invited

Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis
Ryosuke Fujiki; Akinobu Sato; Katsuhiko Hata; Fumi Tashiro; Noriko Yasuhara; Jun-ichi Miyazaki; Yoshihiro Yoneda; Masashi Fujitani; Toshihide Yamashita
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2013, Refereed, Not invited

Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors
Rashid Mehmood; Noriko Yasuhara; Masahiro Fukumoto; Souichi Oe; Taro Tachibana; Yoshihiro Yoneda
MOLECULAR BIOLOGY OF THE CELL, Oct. 2011, Refereed, Not invited

Cell type-specific transcriptional regulation of the gene encoding importin-alpha 1
Yasunao Kamikawa; Noriko Yasuhara; Yoshihiro Yoneda
EXPERIMENTAL CELL RESEARCH, Aug. 2011, Refereed, Not invited

Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin beta
Ryo Ohara; Katsuhiko Hata; Noriko Yasuhara; Rashid Mehmood; Yoshihiro Yoneda; Masanori Nakagawa; Toshihide Yamashita
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2011, Refereed, Not invited

Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin alpha 5
Jonathan Nardozzi; Nikola Wenta; Noriko Yasuhara; Uwe Vinkemeier; Gino Cingolani
JOURNAL OF MOLECULAR BIOLOGY, Sep. 2010, Refereed, Not invited

Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization
Rashid Mehmood; Noriko Yasuhara; Souichi Oe; Masahiro Nagai; Yoshihiro Yoneda
EXPERIMENTAL CELL RESEARCH, Jun. 2009, Refereed, Not invited

Triggering neural differentiation of ES cells by subtype switching of importin-α.
Yasuhara N; Shibazaki N; Tanaka S; Nagai M; Kamikawa Y; Oe S; Asally M; Kamachi Y; Kondoh H; Yoneda Y.
Nat Cell Biol., Jan. 2007, Refereed, Not invited

Importin alpha/beta-mediated nuclear protein import is regulated in a cell cycle-dependent manner
N Yasuhara; E Takeda; H Inoue; Kotera, I; Y Yoneda
EXPERIMENTAL CELL RESEARCH, Jul. 2004, Refereed, Not invited

Identification of Ewing's sarcoma gene product as a glycoprotein using a monoclonal antibody that recognizes an immunodeterminant containing O-linked N-acetylglucosamine moiety
Y Matsuoka; Y Matsuoka; S Shibata; N Yasuhara; Y Yoneda
HYBRIDOMA AND HYBRIDOMICS, Aug. 2002, Refereed, Not invited

Programmed cell death triggered by insect steroid hormone, 20-hydroxyecdysone, in the anterior silk gland of the silkworm, Bombyx mori
J Terashima; N Yasuhara; M Iwami; S Sakurai
DEVELOPMENT GENES AND EVOLUTION, Nov. 2000, Refereed, Not invited

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
JH Lee; T Takahashi; N Yasuhara; J Inazawa; S Kamada; Y Tsujimoto
ONCOGENE, Nov. 1999, Refereed, Not invited

Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy
H Iwahashi; Y Eguchi; N Yasuhara; T Hanafusa; Y Matsuzawa; Y Tsujimoto
NATURE, Nov. 1997, Refereed, Not invited

A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis
S Kagaya; C Kitanaka; Noguchi, I; T Mochizuki; A Sugiyama; A Asai; N Yasuhara; Y Eguchi; Y Tsujimoto; Y Kuchino
MOLECULAR AND CELLULAR BIOLOGY, Nov. 1997, Refereed, Not invited

Evidence against a functional site for Bcl-2 downstream of caspase cascade in preventing apoptosis
N Yasuhara; S Sahara; S Kamada; Y Eguchi; Y Tsujimoto
ONCOGENE, Oct. 1997, Refereed, Not invited

Essential role of active nuclear transport in apoptosis
N Yasuhara; Y Eguchi; T Tachibana; N Imamoto; Y Yoneda; Y Tsujimoto
GENES TO CELLS, Jan. 1997, Refereed, Not invited

核―細胞質間分子輸送による細胞の高次機能制御
上川泰直、安原徳子、米田悦啓
実験医学, 2010, Not refereed, Not invited

The role of the nuclear transport system in cell differentiation
Noriko Yasuharaa; Masahiro Oka; Yoshihiro Yoneda
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Jul. 2009, Refereed, Not invited

細胞分化と核―細胞質間分子輸送システム
安原徳子、岡正啓、米田悦啓
最新医学, Mar. 2009, Not refereed, Not invited

核―細胞質間蛋白質輸送と高次生命現象
安原徳子、米田悦啓
生体の科学, 2008, Not refereed, Not invited

細胞分化を制御する核輸送受容体 importinα
安原徳子 米田悦啓
蛋白質核酸酵素, May 2007, Not refereed, Not invited

細胞周期依存的な能動核タンパク質輸送システムの制御とメカニズム
安原徳子; 武田英里; 井上仁美; 小寺一平; 米田悦啓
日本分子生物学会年会プログラム・講演要旨集, 2003

Regulation of Downstream Targets - Advances in Protein Chemistry and Structural Biology, Volume 134
Kazuya Jibiki; Takashi S Kodama; Noriko Yasuhara, Contributor, Chapter Seven - Importin alpha family NAAT/IBB domain: Functions of a pleiotropic long chameleon sequence.
Academic Press, an imprint of Elsevier, Mar. 2023
9780443131813

Importin α proteins differentially localize in cytoplasm
柴崎典子、地引和也、岡安美奈、安原徳子
MBSJ2020, Dec. 2020, Not invited

A nuclear transport receptor importin α2 associates with chromatin via novel DNA binding domain, NAAT
安原徳子
MBSJ2020, Dec. 2020, Invited

新規ドメインを介した核輸送因子importinαのDNA結合様式解析
地引和也
第93回日本生化学会大会, Sep. 2020, Not invited

核輸送因子importin αのクロマチン結合解析
地引 和也、野本 心、川瀬 陽太、 斉藤 典子、末永 敦、児玉 高志、 安原 徳子
第72回日本細胞生物学会大会, Jun. 2020, Not invited

核輸送因子importin α2はDNAとの結合を介して遺伝子の発現に関わる
地引和也、安原徳子
第42回日本分子生物学会年会, Dec. 2019, Not invited

核輸送因子によるクロマチン結合を介した遺伝子発現制御
安原徳子
第42回日本分子生物学会年会, Dec. 2019, 日本分子生物学会, Invited

未分化ES細胞において核輸送因子importin α2は多数のゲノム領域に結合する
地引和也
第92回日本生化学会大会, Sep. 2019, Not invited

Development of NASH-HCC treatment targeting novel gene regulatory functions of nuclear transport receptor proteins
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2023 - 31 Mar. 2026
江口 暁子; 安原 徳子

核輸送因子による新たなDNAターゲッティング機構の解明
日本学術振興会, 科学研究費助成事業, 01 Apr. 2021 - 31 Mar. 2025
安原 徳子

核輸送因子局在化ゾーンによる細胞核内外オルガネラ連携
日本学術振興会, 科学研究費助成事業, 01 Apr. 2018 - 31 Mar. 2020
安原 徳子

The role of the nucleocytoplasmic transport during embryogenesis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2015 - 31 Mar. 2018
YASUHARA Noriko

Mechanisms of nuclear transport factor/nucleoporin-mediated chromatin regulation
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 28 Jun. 2013 - 31 Mar. 2018
YONEDA Yoshihiro

Control of transcription factors and epigenetic factors via nuclear transport and its application to targeted therapy
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2014 - 31 Mar. 2017
KANEKO Hiroki; YONEDA Yoshihiro; YASUHARA Noriko; KONDOU Yutaka; OKUZAKI Daisuke; YAMAGISHI Ryosuke; SHIMADA Jiro

An integrative understanding of physiological processes based on the functional analysis of nuclear transport factors, importins
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 31 May 2012 - 31 Mar. 2015
YONEDA Yoshihiro; OKA Masahiro; YASUHARA Noriko

the mechanism of development regulated by the nucleocytoplasmic transport
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2015
YASUHARA Noriko; TAKAOKA Kastuyoshi

胚発生過程における遺伝情報場への分子輸送の時空間制御
日本学術振興会, 科学研究費助成事業, 01 Apr. 2011 - 31 Mar. 2013
安原 徳子

Study for a novel mechanism of developmental regulation via nucleocytoplasmic transport
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2009 - 2011
YASUHARA Noriko

初期胚発生における遺伝情報場への分子輸送の時空間制御
日本学術振興会, 科学研究費助成事業, 2009 - 2010
安原 徳子