Ogawa Kenji
| College of Bioresource Sciences Department of Veterinary Medicine | Professor |
Researcher Information
Career
- Apr. 2019 - Present
理化学研究所, 創薬シード化合物探索基盤ユニット, 客員主管研究員 - Apr. 2019 - Present
日本大学生物資源科学部, 獣医伝染病学研究室, 教授 - Apr. 2018 - Mar. 2019
理化学研究所, 創薬シード化合物探索基盤ユニット, 専任研究員 - Apr. 2013 - Mar. 2018
理化学研究所, 吉田化学遺伝学研究室, 専任研究員 - Apr. 2010 - Mar. 2013
理化学研究所, 分子リガンド探索研究チーム, 専任研究員 - Apr. 2007 - Mar. 2010
理化学研究所, 辻本細胞生化学研究室, 専任研究員 - Apr. 2003 - Mar. 2007
理化学研究所, 細胞生化学研究室, 先任研究員 - Jul. 2000 - Mar. 2003
Indiana University School of Medicine, Department of Medical and Molecular Genetics, Visiting Scientist - May 1995 - Jun. 2000
理化学研究所, 動物試験室, 研究員 - Jul. 1993 - Apr. 1995
The University of Tokyo, 農学部 獣医解剖学教室, 助手
Research activity information
Paper
- HDAC1 and HDAC2 are bidirectional enzymes that catalyze histone sorbylation to induce epigenetic alterations
Akihiro Ito; Kota Noritsugu; Yuki Shimizu; Takehiro Suzuki; Komei Aoki; Tamiko Nozaki; Shigehiro Kawashima; Masaya Yamazaki; Kazuya Yamagata; Kota Koike; Kosuke Dodo; Kenji Ogawa; Mikiko Sodeoka; Minoru Yoshida; Naoshi Dohmae; Yoshito Kumagai
Jan. 2025 - Major HBV splice variant encoding a novel protein important for infection.
Chen-Yen Chung; Cheng-Pu Sun; Mi-Hua Tao; Hui-Lin Wu; Sheng-Han Wang; Shiou-Hwei Yeh; Qing-Bing Zheng; Quan Yuan; Ning-Shao Xia; Kenji Ogawa; Kenji Nakashima; Tetsuro Suzuki; Pei-Jer Chen
Journal of hepatology, Feb. 2024 - UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3
Jing Yan; Hengsen Zhang; Yuna Tomochika; Bin Chen; Yashuang Ping; Md. Shoriful Islam; Shuhei Aramaki; Tomohito Sato; Yu Nagashima; Tomohiko Nakamura; Tomoaki Kahyo; Daita Kaneda; Kenji Ogawa; Minoru Yoshida; Mitsutoshi Setou
Biomedicines, Sep. 2023, Refereed - UBL3 Interacts with Alpha-Synuclein in Cells and the Interaction Is Downregulated by the EGFR Pathway Inhibitor Osimertinib.
Bin Chen; Md Mahmudul Hasan; Hengsen Zhang; Qing Zhai; A S M Waliullah; Yashuang Ping; Chi Zhang; Soho Oyama; Mst Afsana Mimi; Yuna Tomochika; Yu Nagashima; Tomohiko Nakamura; Tomoaki Kahyo; Kenji Ogawa; Daita Kaneda; Minoru Yoshida; Mitsutoshi Setou
Biomedicines, Jun. 2023 - Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent.
Saaya Sekine; Shohei Takase; Runa Hayase; Kota Noritsugu; Yuki Maemoto; Yasue Ichikawa; Kenji Ogawa; Yasumitsu Kondoh; Hiroyuki Osada; Minoru Yoshida; Akihiro Ito
Bioscience, biotechnology, and biochemistry, Apr. 2023 - Lysine long-chain fatty acylation regulates the TEAD transcription factor.
Kota Noritsugu; Takehiro Suzuki; Kosuke Dodo; Kenji Ohgane; Yasue Ichikawa; Kota Koike; Satoshi Morita; Takashi Umehara; Kenji Ogawa; Mikiko Sodeoka; Naoshi Dohmae; Minoru Yoshida; Akihiro Ito
Cell reports, Apr. 2023 - Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain.
Yoshikuni Goto; Takahiro J Nakamura; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto
Frontiers in molecular biosciences, 2020 - 小胞体アミノペプチダーゼ1遺伝子欠損は、セロトニン合成を亢進することで不安を誘発する
斎藤 朱里; 後藤 芳邦; 中村 孝博; 小川 健司; 服部 明; 辻本 雅文
日本生化学会大会プログラム・講演要旨集, Sep. 2019 - 小胞体アミノペプチダーゼ1遺伝子欠損はセロトニン合成亢進を介して不安障害を惹起する
小林 春奈; 後藤 芳邦; 中村 孝博; 小川 健司; 服部 明; 辻本 雅文
日本薬学会年会要旨集, Mar. 2019 - Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1.
Yoshikuni Goto; Takahiro J Nakamura; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto
Journal of biochemistry, Feb. 2019 - An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People.
Sanae Hayashi; Anis Khan; Brenna C Simons; Chriss Homan; Takeshi Matsui; Kenji Ogawa; Keigo Kawashima; Shuko Murakami; Satoru Takahashi; Masanori Isogawa; Kazuho Ikeo; Masashi Mizokami; Brian J McMahon; Yasuhito Tanaka
Hepatology (Baltimore, Md.), Jan. 2019 - Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation.
Yoshikuni Goto; Yuko Ogawa; Hiroki Tsumoto; Yuri Miura; Takahiro J Nakamura; Kenji Ogawa; Yoshihiro Akimoto; Hayato Kawakami; Tamao Endo; Ryohei Yanoshita; Masafumi Tsujimoto
Biochimica et biophysica acta. Molecular cell research, Jun. 2018 - 小胞体アミノペプチダーゼはエンドトキシンショック時に惹起される一酸化窒素合成を亢進する
後藤 芳邦; 小川 健司; 中村 孝博; 服部 明; 辻本 雅文
日本生化学会大会プログラム・講演要旨集, Sep. 2016 - Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Yasushi Takemoto; Akihiro Ito; Hideaki Niwa; Mutsumi Okamura; Takashi Fujiwara; Tomoya Hirano; Noriko Handa; Takashi Umehara; Takeshi Sonoda; Kenji Ogawa; Mohammad Tariq; Norikazu Nishino; Shingo Dan; Hiroyuki Kagechika; Takao Yamori; Shigeyuki Yokoyama; Minoru Yoshida
Journal of medicinal chemistry, Apr. 2016 - Cyclic Stretch Augments Production of Neutrophil Chemokines, Matrix Metalloproteinases, and Activin A in Human Endometrial Stromal Cells
Gentaro Izumi; Kaori Koga; Miwako Nagai; Yoko Urata; Masashi Takamura; Miyuki Harada; Tetsuya Hirata; Yasushi Hirota; Kenji Ogawa; Satoshi Inoue; Tomoyuki Fujii; Yutaka Osuga
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Jun. 2015, Refereed, Not invited - Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.
Yoshikuni Goto; Kenji Ogawa; Takahiro J Nakamura; Akira Hattori; Masafumi Tsujimoto
Journal of biochemistry, Jun. 2015 - 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下
後藤 芳邦; 小川 健司; 中村 孝博; 服部 明; 辻本 雅文
日本生化学会大会プログラム・講演要旨集, Oct. 2014 - RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes.
Kimio J Tanaka; Kenji Ogawa; Masatoshi Takagi; Naoko Imamoto; Ken Matsumoto; Masafumi Tsujimoto
The Journal of biological chemistry, Jul. 2014 - TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.
Yoshikuni Goto; Kenji Ogawa; Takahiro J Nakamura; Akira Hattori; Masafumi Tsujimoto
Journal of immunology (Baltimore, Md. : 1950), May 2014 - マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌
後藤 芳邦; 小川 健司; 中村 孝博; 服部 明; 辻本 雅文
日本生化学会大会プログラム・講演要旨集, Sep. 2013 - Follistatin is induced by IL-1β and TNF-α in stromal cells from endometrioma.
Ikumi Akiyama; Osamu Yoshino; Yutaka Osuga; Gentaro Izumi; Yoko Urata; Yasushi Hirota; Tetsuya Hirata; Miyuki Harada; Kaori Koga; Kenji Ogawa; Shiro Kozuma
Reproductive sciences (Thousand Oaks, Calif.), Jun. 2013 - Expression of activin receptor-like kinase 7 in adipose tissues.
Masaru Murakami; Mitsuyuki Shirai; Ryo Ooishi; Asako Tsuburaya; Kumiko Asai; Osamu Hashimoto; Kenji Ogawa; Yoshii Nishino; Masayuki Funaba
Biochemical genetics, Apr. 2013 - 小胞体アミノペプチダーゼの分泌を介したマクロファージのNO産生亢進
後藤 芳邦; 小川 健司; 服部 明; 辻本 雅文
日本生化学会大会プログラム・講演要旨集, Dec. 2012 - Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma.
Yoshikuni Goto; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto
The Journal of biological chemistry, Jun. 2011 - Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment.
Ryohei Furumai; Akihiro Ito; Kenji Ogawa; Satoko Maeda; Akiko Saito; Norikazu Nishino; Sueharu Horinouchi; Minoru Yoshida
Cancer science, May 2011 - The effects of TGF-β1 on the expression of type IV collagenases in mouse peritoneal macrophages.
Kenji Ogawa; Masayuki Funaba; Masafumi Tsujimoto
Molecular biology reports, Feb. 2011 - Activin in humoral immune responses.
Kenji Ogawa; Masayuki Funaba
Vitamins and hormones, 2011 - Receptor expression modulates the specificity of transforming growth factor-beta signaling pathways.
Masaru Murakami; Hiroyuki Kawachi; Kenji Ogawa; Yoshii Nishino; Masayuki Funaba
Genes to cells : devoted to molecular & cellular mechanisms, Apr. 2009 - A dual role of activin A in regulating immunoglobulin production of B cells.
Kenji Ogawa; Masayuki Funaba; Masafumi Tsujimoto
Journal of leukocyte biology, Jun. 2008 - Suppression of NF-kappaB and IRF-1-induced transcription of the murine IL-12 p40 by transforming growth factor-beta Smad pathway in macrophages.
Kenji Ogawa; Masayuki Funaba; Masafumi Tsujimoto
Molecular and cellular biochemistry, Jan. 2008 - RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes.
Kimio J Tanaka; Kenji Ogawa; Masatoshi Takagi; Naoko Imamoto; Ken Matsumoto; Masafumi Tsujimoto
The Journal of biological chemistry, Dec. 2006 - Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions.
Masayuki Funaba; Teruo Ikeda; Masaru Murakami; Kenji Ogawa; Yoshii Nishino; Kunihiro Tsuchida; Hiromu Sugino; Matanobu Abe
Cellular signalling, Dec. 2006 - Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
Kenji Ogawa; Masayuki Funaba; Yan Chen; Masafumi Tsujimoto
Journal of immunology (Baltimore, Md. : 1950), Nov. 2006 - Identification of tocopherol-associated protein as an activin/TGF-beta-inducible gene in mast cells
Masayuki Funaba; Masaru Murakami; Teruo Ikeda; Kenji Ogawa; Kunihiro Tsuchida; Hiromu Sugino
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Aug. 2006, Refereed, Not invited - Identification of tocopherol-associated protein as an activin/TGF-beta-inducible gene in mast cells.
Masayuki Funaba; Masaru Murakami; Teruo Ikeda; Kenji Ogawa; Kunihiro Tsuchida; Hiromu Sugino
Biochimica et biophysica acta, Aug. 2006 - Transcriptional regulation of plasminogen activator inhibitor-1 by transforming growth factor-beta, activin A and microphthalmia-associated transcription factor.
Masaru Murakami; Teruo Ikeda; Taiju Saito; Kenji Ogawa; Yoshii Nishino; Kohei Nakaya; Masayuki Funaba
Cellular signalling, Feb. 2006 - Transcriptional regulation of mouse mast cell protease-7 by TGF-beta.
Masayuki Funaba; Teruo Ikeda; Masaru Murakami; Kenji Ogawa; Yoshii Nishino; Kunihiro Tsuchida; Hiromu Sugino; Matanobu Abe
Biochimica et biophysica acta, 2006 - Up-regulation of mouse mast cell protease-6 gene by transforming growth factor-beta and activin in mast cell progenitors.
Masayuki Funaba; Teruo Ikeda; Masaru Murakami; Kenji Ogawa; Matanobu Abe
Cellular signalling, Jan. 2005 - Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-beta is mediated by a nuclear factor-kappaB site.
Kenji Ogawa; Feifei Chen; Chenzhong Kuang; Yan Chen
The Biochemical journal, Jul. 2004 - Transcriptional activation of mouse mast cell Protease-7 by activin and transforming growth factor-beta is inhibited by microphthalmia-associated transcription factor.
Masayuki Funaba; Teruo Ikeda; Masaru Murakami; Kenji Ogawa; Kunihiro Tsuchida; Hiromu Sugino; Matanobu Abe
The Journal of biological chemistry, Dec. 2003 - Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor.
Masaru Murakami; Teruo Ikeda; Kenji Ogawa; Masayuki Funaba
Biochemical and biophysical research communications, Nov. 2003 - Transcriptional regulation of tristetraprolin by transforming growth factor-beta in human T cells.
Kenji Ogawa; Feifei Chen; Young-June Kim; Yan Chen
The Journal of biological chemistry, Aug. 2003 - Calcium-regulated expression of activin A in RBL-2H3 mast cells.
Masayuki Funaba; Teruo Ikeda; Kenji Ogawa; Matanobu Abe
Cellular signalling, Jun. 2003 - Role of activin A in murine mast cells: modulation of cell growth, differentiation, and migration.
Masayuki Funaba; Teruo Ikeda; Kenji Ogawa; Masaru Murakami; Matanobu Abe
Journal of leukocyte biology, Jun. 2003 - Regulation of TG-interacting factor by transforming growth factor-beta.
Feifei Chen; Kenji Ogawa; Raman P Nagarajan; Meiyu Zhang; Chenzhong Kuang; Yan Chen
The Biochemical journal, Apr. 2003 - Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit.
Feifei Chen; Kenji Ogawa; Xubao Liu; Teresa M Stringfield; Yan Chen
The Biochemical journal, Jun. 2002 - Suppressed bone induction by follistatin in spontaneously hypercholesterolemic rat bone
Masayuki Funaba; Takuya Murata; Eri Murata; Kenji Ogawa; Matanobu Abe; Michio Takahashi; Kunio Torii
Life Sciences, Jul. 1997 - Follistatin-like immunoreactivity in the cytoplasm and nucleus of spermatogenic cells in the rat
Kenji Ogawa; Osamu Hashimoto; Masamichi Kurohmaru; Takeo Mizutani; Hiromu Sugino; Yoshihiro Hayashi
European Journal of Endocrinology, 1997 - Follistatin and activin in bone: Expression and localization during endochondral bone development
Masayuki Funaba; Kenji Ogawa; Takuya Murata; Hisako Fujimura; Eri Murata; Matanobu Abe; Michio Takahashi; Kunio Torii
Endocrinology, 1996 - Effect of extracellular matrix on two cell lines established from mongolian gerbil's (meriones unguiculatus) malignant melanoma
Osamu Hashimoto; Kenji Ogawa; Masamichi Kurohmaru; Yoshihiro Hayashi
Journal of Veterinary Medical Science, 1995
MISC
- 小胞体アミノペプチダーゼ1の機能低下は,不安障害様症状を惹起する
後藤芳邦; 中村孝博; 杉山瑞輝; 服部明; 小川健司; 辻本雅文
日本分子生物学会年会プログラム・要旨集(Web), 2024 - Dysfuction of ER-aminopeptidase 1 induce serotonin-dependent anxiety
平井杏奈; 鈴木優香; 中村孝博; 小川健司; 服部明; 辻本雅文; 後藤芳邦
日本分子生物学会年会プログラム・要旨集(Web), 2022 - Hepatocellular Carcinoma-associated Core N51H Mutation with BCP PC mutations in HBV Genotype F1b Enhances Infectivity and Up-regulates c-Myc and GAB2
Sanae Hayashi; Anis A. Khan; Kenji Ogawa; Keigo Kawashima; Brenna Simons-Petrusa; Chriss E. Homan; Brian J. McMahon; Shuko Murakami; Sayuki Iijima; Masanori Isogawa; Tsunamasa Watanabe; Yasuhito Tanaka
HEPATOLOGY, Oct. 2016, Not refereed, Not invited - ほ乳類におけるアクチビン作用の多様性 組織特異的転写因子MITFによるアクチビンシグナルの制御
舟場 正幸; 池田 輝雄; 村上 賢; 小川 健司; 土田 邦博; 杉野 弘; 阿部 又信
日本獣医学会学術集会講演要旨集, Mar. 2004, Not refereed, Not invited - 組織特異的転写因子MITFはSmad3によるマスト細胞プロテアーゼ-7(mMCP-7)遺伝子の転写を抑制する
舟場 正幸; 池田 輝雄; 村上 賢; 小川 健司; 土田 邦博; 杉野 弘; 阿部 又信
日本獣医学会学術集会講演要旨集, Sep. 2003, Not refereed, Not invited
Research Themes
- Elucidation of Replication Mechanisms and Development of Drug Discovery Platforms Using Ebola Virus Replication Inhibitors
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2018 - 31 Mar. 2022
OGAWA Kenji - Identification of compounds that selectively inhibit rabies virus replication
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2015 - 31 Mar. 2017
Ogawa Kenji - Pathophysiological roles of M1 aminopeptidases
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2013 - 31 Mar. 2016
TSUJIMOTO Masafumi; TAKASU Kiyosei; HATTORI Akira; OGAWA Yuko; GOTO Yoshikuni; OGAWA Kenji - Role of activin A in the innate immune responses -Identification of compounds that regulate innate immune responses-
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2015
OGAWA Kenji - Regulation of allergic inflammation by TGF-b superfamily proteins
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2008 - 2010
OGAWA KENJI - Function of Activin A in helper T cells
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2006 - 2007
KENJI Ogawa - Function of the Bone Morphogenetic Protein in Immune System
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2003 - 2004
OGAWA Kenji - 免疫担当細胞におけるBoneMorphogeneticProteinの機能
日本学術振興会, 科学研究費助成事業, 2000 - 2000
小川 健司 - Activin/follistatin in mouse lymphocytes
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1998 - 1999
OGAWA Kenji - Cellular and molecular analysis of cryptic testes in dolphins
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1997 - 1998
HAYASHI Yoshihiro; OGAWA Kenji; KUROHMARU Masamichi - Inhibitory effect of chloroform-resistant bacteria on polyposis in the small intestine of gnotobiote BALB/c mice
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1996 - 1997
MIZUTANI Takeo; OGAWA Kenji - Analysis of inhibitory mechanism of fertilization between different species
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1995 - 1996
HAYASHI Yoshihiro; OGAWA Kenji; KUROHMARU Masamichi - Establishment of accurate in vitro measurement for testicular toxic te
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1995 - 1996
KUROHMARU Masamichi; HONDO Eiichi; OGURA Atsuo; OGAWA Kenji; HAYASHI Yoshihiro - 精巣における各種ホルモン・成長因子受容体の発現の解析
日本学術振興会, 科学研究費助成事業, 1995 - 1995
九郎丸 正道; 小川 健司; 倉本 和直 - 膵ランゲルハンス島におけるインヒビン、アクチビンおよびフォリスタチンの役割
日本学術振興会, 科学研究費助成事業, 1995 - 1995
小川 健司 - 食虫目トガリネズミ科動物における生殖戦略の相違に基づく精巣組織の適応変化
日本学術振興会, 科学研究費助成事業, 1994 - 1994
九郎丸 正道; 遠藤 秀紀; 小川 健司; 林 良博 - ラットの精子発生におけるアクチビンおよびフォリスタチンの役割
日本学術振興会, 科学研究費助成事業, 1994 - 1994
小川 健司
