Tokuda Eiichi
| Department of Pharmacy | Assistant Professor |
ProfileAmyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with no effective treatment so for. When I was an undergraduate student, I learned what ALS is and understood what a severe disease ALS is in a lecture. The nature of ALS as the disease made me extremely amazed and shocked. Since then, I have been studying basic research on ALS. The mission of my research is to elucidate how superoxide dismutase-1 (SOD1), one of the responsible protein for ALS, kills motor neurons. My current research is focused on understanding why and how SOD1 obtains a property on the cell-to-cell transmission throughout the central nervous system in vivo such as mouse models and patients with ALS.
Researcher Information
Research Keyword
Field Of Study
Career
- Apr. 2019 - Present
Nihon University, School of Pharmacy, Senior Research Associate - Apr. 2018 - Mar. 2019
Tokushima Bunri University, Faculty of Pharmaceutical Sciences, Senior Research Associate - Apr. 2015 - Mar. 2018
Keio University, Department of Chemistry, Assistant Professor - Apr. 2010 - Mar. 2015
Umea University, Sweden, Department of Medical Biosciences, Post-doc - Apr. 2008 - Mar. 2010
Japan Society of the Promotion of Sciences, Research Fellow
Educational Background
Research activity information
Award
Paper
- MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons
Eiichi Tokuda; Yume Sakashita; Naoya Tokoro; Ayano Date; Yasuhiro Kosuge; Tomohiro Miyasaka
International Journal of Molecular Sciences, May 2024, Refereed, Not invited
Lead - FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
Yuzo Fujino; Morio Ueyama; Taro Ishiguro; Daisaku Ozawa; Toshihiko Sugiki; Hayato Ito; Asako Murata; Akira Ishiguro; Tania F. Gendron; Kohji Mori; Eiichi Tokuda; Tomoya Taminato; Takuya Konno; Akihide Koyama; Yuya Kawabe; Toshihide Takeuchi; Yoshiaki Furukawa; Toshimichi Fujiwara; Manabu Ikeda; Toshiki Mizuno; Hideki Mochizuki; Hidehiro Mizusawa; Keiji Wada; Kinya Ishikawa; Osamu Onodera; Kazuhiko Nakatani; Hideki Taguchi; Leonard Petrucelli; Yoshitaka Nagai
eLife, Jul. 2023, Refereed, Not invited - A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells.
Chika Takashima; Yasuhiro Kosuge; Masahisa Inoue; Shin-Ichi Ono; Eiichi Tokuda
International Journal of Molecular Sciences, Apr. 2021, Refereed, Not invited
Last - Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS
Mikako Hirose; Mito Asano; Saori Watanabe-Matsumoto; Koji Yamanaka; Yoichiro Abe; Masato Yasui; Eiichi Tokuda; Yoshiaki Furukawa; Hidemi Misawa
Neuroscience Research, Dec. 2020, Refereed, Not invited - Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?
Yoshiaki Furukawa; Eiichi Tokuda
Translational Neurodegeneration, Dec. 2020, Refereed, Not invited - Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation.
Itsuki Anzai; Eiichi Tokuda; Sumika Handa; Hidemi Misawa; Shuji Akiyama; Yoshiaki Furukawa
Free radical biology & medicine, Feb. 2020, Refereed, Not invited - Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis.
Eiichi Tokuda; Yo-Ichi Takei; Shinji Ohara; Noriko Fujiwara; Isao Hozumi; Yoshiaki Furukawa
Molecular neurodegeneration, Nov. 2019, Refereed, Not invited
Lead - [Prion-like Properties of Misfolded Cu/Zn-superoxide Dismutase in Amyotrophic Lateral Sclerosis: Update and Perspectives].
Eiichi Tokuda
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, Jan. 2019, Refereed, Not invited
Lead - A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis
Eiichi Tokuda; Takao Nomura; Shinji Ohara; Seiji Watanabe; Koji Yamanaka; Yuta Morisaki; Hidemi Misawa; Yoshiaki Furukawa
Biochimica et Biophysica Acta - Molecular Basis of Disease, Jun. 2018, Refereed, Not invited
Lead - Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state.
Fujiwara N; Wagatsuma M; Oba N; Yoshihara D; Tokuda E; Sakiyama H; Eguchi H; Ichihashi M; Furukawa Y; Inoue T; Suzuki K
PLoS One, 2018, Refereed, Not invited - An essential role of N-terminal domain of copper chaperone in the enzymatic activation of Cu/Zn-superoxide dismutase
Mami Fukuoka; Eiichi Tokuda; Kenta Nakagome; Zhiliang Wu; Isao Nagano; Yoshiaki Furukawa
JOURNAL OF INORGANIC BIOCHEMISTRY, Oct. 2017, Refereed, Not invited - Abnormal protein oligomers for neurodegeneration
Eiichi Tokuda; Yoshiaki Furukawa
ONCOTARGET, Jun. 2017, Refereed, Not invited
Lead - Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
Taro Ishiguro; Nozomu Sato; Morio Ueyama; Nobuhiro Fujikake; Chantal Sellier; Akemi Kanegami; Eiichi Tokuda; Bita Zamiri; Terence Gall-Duncan; Mila Mirceta; Yoshiaki Furukawa; Takanori Yokota; Keiji Wada; J. Paul Taylor; Christopher E. Pearson; Nicolas Charlet-Berguerand; Hidehiro Mizusawa; Yoshitaka Nagai; Kinya Ishikawa
NEURON, Apr. 2017, Refereed, Not invited - A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis
Itsuki Anzai; Eiichi Tokuda; Atsushi Mukaiyama; Shuji Akiyama; Fumito Endo; Koji Yamanaka; Hidemi Misawa; Yoshiaki Furukawa
PROTEIN SCIENCE, Mar. 2017, Refereed, Not invited - Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis
Eiichi Tokuda; Itsuki Anzai; Takao Nomura; Keisuke Toichi; Masahiko Watanabe; Shinji Ohara; Seiji Watanabe; Koji Yamanaka; Yuta Morisaki; Hidemi Misawa; Yoshiaki Furukawa
MOLECULAR NEURODEGENERATION, Jan. 2017, Refereed, Not invited
Lead - Aggregation of FET proteins as a pathological change in amyotrophic lateral sclerosis
Yoshiaki Furukawa; Eiichi Tokuda
Advances in Experimental Medicine and Biology, 2017, Refereed, Not invited - Screening of drugs inhibiting in vitro oligomerization of Cu/Zn-superoxide dismutase with a mutation causing amyotrophic lateral sclerosis
Itsuki Anzai; Keisuke Toichi; Eiichi Tokuda; Atsushi Mukaiyama; Shuji Akiyama; Yoshiaki Furukawa
Frontiers in Molecular Biosciences, Aug. 2016, Refereed, Not invited - Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations
Eiichi Tokuda; Yoshiaki Furukawa
International Journal of Molecular Sciences, May 2016, Refereed, Not invited
Lead - Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase
Eiichi Tokuda; Thomas Braennstroem; Peter M. Andersen; Stefan L. Marklund
ACTA NEUROPATHOLOGICA COMMUNICATIONS, Jan. 2016, Refereed, Not invited - Regulation of Intracellular Copper by Induction of Endogenous Metallothioneins Improves the Disease Course in a Mouse Model of Amyotrophic Lateral Sclerosis
Eiichi Tokuda; Shunsuke Watanabe; Eriko Okawa; Shin-ichi Ono
Neurotherapeutics, Apr. 2015, Refereed, Not invited
Lead - Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1
Eiichi Tokuda; Eriko Okawa; Shunsuke Watanabe; Shin-ichi Ono
Human Molecular Genetics, Mar. 2014, Refereed, Not invited
Lead - A possible novel pharmacological therapy for Parkinson's disease using the pleiotropic property of Selegiline
Shin-Ichi Ono; Ryuji Sorte; Ei-Ichi Tokuda
Current Topics in Pharmacology, 2014 - Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities
Eiichi Tokuda; Eriko Okawa; Shunsuke Watanabe; Shin-Ichi Ono; Stefan L. Marklund
Neurobiology of Disease, Jun. 2013, Refereed, Not invited
Lead - An attempt to treat amyotrophic lateral sclerosis by intracellular copper modification using ammonium tetrathiomolybdate and/or metallothionein: Fundamentals and perspective
Shin-Ichi Ono; Ei-Ichi Tokuda; Eriko Okawa; Shunsuke Watanabe
Brain Diseases and Metalloproteins, Jul. 2012, Refereed, Not invited - Effects of Pergolide Mesilate on Metallothionein mRNAs Expression in a Mouse Model for Parkinson Disease
Shin-ichi Ono; Kohji Hirai; Ei-ichi Tokuda
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2009, Refereed, Not invited - Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis
Eiichi Tokuda; Eriko Okawa; Shin-ichi Ono
Journal of Neurochemistry, Oct. 2009, Refereed, Not invited
Lead - Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis
Eiichi Tokuda; Shin-ichi Ono; Kumiko Ishige; Shunsuke Watanabe; Eriko Okawa; Yoshihisa Ito; Takashi Suzuki
EXPERIMENTAL NEUROLOGY, Sep. 2008, Refereed, Not invited - Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis
Eiichi Tokuda; Shin-ichi Ono; Kumiko Ishige; Shunsuke Watanabe; Eriko Okawa; Yoshihisa Ito; Takashi Suzuki
BRAIN RESEARCH, May 2007, Refereed, Not invited - Different patterns in the induction of metallothionein mRNA synthesis among isoforms after acute ethanol administration
Shin-Ichi Ono; Yuriko Ishizaki; Ei-Ichi Tokuda; Kei-Ichi Tabata; Satoru Asami; Takashi Suzuki
BIOLOGICAL TRACE ELEMENT RESEARCH, Feb. 2007, Refereed, Not invited - Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis
Eiichi Tokuda; Shin-ichi Ono; Kumiko Ishige; Akira Naganuma; Yoshihisa Ito; Takashi Suzuki
Toxicology, Jan. 2007, Refereed, Not invited
Lead - Upregulation of metallothionein-I mRNA expression in a rodent model for amyotrophic lateral sclerosis
Shin-ichi Ono; Yuko Endo; Ei-ichi Tokuda; Kumiko Ishige; Kei-ichi Tabata; Satoru Asami; Yoshihisa Ito; Takashi Suzuki
BIOLOGICAL TRACE ELEMENT RESEARCH, Oct. 2006, Refereed, Not invited
MISC
- SOD1タンパク質が毒性の高い異常な構造を形成する新たなメカニズム
徳田栄一
ファルマシア(Web), 2024 - Development of hemodiagnosis for sporadic ALS based on the seeding reaction by misfolded SOD1
徳田栄一; 川名麻衣
日本薬学会年会要旨集(Web), 2024 - Characterization of misfolded SOD1 species that are recognized by a commercially available antibody MS785
徳田栄一; 阪下優芽; 山老直哉
日本薬学会年会要旨集(Web), 2023 - ALS病因タンパク質の凝集を抑制するZn結合型メタロチオネイン
徳田 栄一; 桂馬 茉衣子; 池田 知亜子; 小菅 康弘; 小野 真一
日本薬学会年会要旨集, Mar. 2022 - Zn結合型メタロチオネインによるALS関連タンパク質の凝集抑制
徳田栄一; 桂馬茉衣子; 池田知亜子; 小菅康弘; 小野真一
日本神経化学会大会抄録集(Web), 2022 - Metallothionein-I protects against pathological aggregation of SOD1 associated with amyotrophic lateral sclerosis
徳田栄一; 桂馬茉衣子; 池田知亜子; 小野真一; 小野真一
Journal of Toxicological Sciences, Jul. 2021 - ALS関連タンパク質凝集体の構造多型に共通した細胞間伝播経路
徳田栄一; 田上美帆; Stefan Marklun; 小野真一
日本薬学会 141年会, Mar. 2021 - ショウジョウバエモデルによるC9orf72関連ALS/FTDの病態解明
上山盛夫; 上山盛夫; 上山盛夫; 石黒太郎; 小澤大作; 小澤大作; 杉木俊彦; 石黒亮; 徳田栄一; 今野卓哉; 小山哲秀; 武内敏秀; 武内敏秀; 古川良明; 藤原敏道; 和田圭司; 小野寺理; 永井義隆; 永井義隆; 永井義隆; 永井義隆
日本臨床ストレス応答学会大会抄録集, 2021 - Disruption of glymphatic system and slow in waste clearance in the SOD1-G93A mouse model of ALS
Mikako Hirose; Asano Mito; Matsumoto Saori; Yamanaka Koji; Abe Yoichiro; Yasui Masato; Tokuda Eiichi; Furukawa Yoshiaki; Misawa Hidemi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021, Not refereed - A conformational feature of extracellular misfolded wild-type and mutant superoxide dismutase-1 with prion-like properties in the extracellular environment surrounding motor neuron-like cells
Eiichi Tokuda; Chika Takashima; Yasuhiro Kosuge; Masahisa Inoue; Shin-ichi Ono
日本毒性学会 第4回 生体金属部会（メタロバイオサイエンス研究会2020）, Nov. 2020
Lead - Distinct influences of ALS-linked SOD1 mutants on endocytosis: implication of strain type of SOD1 aggregates
Eiichi Tokuda; Miho Tagami; Rieko Fujiwara; Asuka Eguchi; Stefan L. Marklund; Shin-ichi Ono
The 43rd Annual Meeting of the Japan Neuroscience Society, Jul. 2020
Lead - 細胞外ミスフォールドSOD1の運動ニューロン毒性 エンドサイトーシスの機能低下とALS病理の関連
徳田栄一; 高島千佳; 田上美帆; 小野真一
日本薬学会年会要旨集, Mar. 2020, Not refereed, Not invited - Involvement of glymphatic system in amyotrophic lateral sclerosis pathology
Mikako Hirose; Asano Mito; Shitara Shusei; Abe Yoichiro; Yasui Masato; Tokuda Eiichi; Furukawa Yoshiaki; Misawa Hidemi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020, Not refereed - 神経変性疾患関連タンパク質SOD1の自己酸化によるミスフォールディング機構
安齋樹; 徳田栄一; 向山厚; 秋山修志; 古川良明
日本細胞生物学会, Dec. 2019, Not refereed, Not invited - 筋萎縮性側索硬化症マウスにおける変異SOD1と glutaredoxinの検討
小野真一; 徳田栄一; 浅見覚
日本毒性学会 第3回 生体金属部会（メタロバイオサイエンス研究会2019）, Oct. 2019 - エンドサイトーシス受容体LRP2によるメタロチオネインの神経内移行: 変異型SOD1毒性の軽減作用
徳田栄一; 井上正久; 小野真一
日本毒性学会 第3回 生体金属部会（メタロバイオサイエンス研究会2019）, Oct. 2019 - Endocytotic uptake of metallothionein by LRP2 is involved in protecting motor neurons from cytotoxicity of an ALS-SOD1 mutant
TOKUDA Eiichi; INOUE Masahisa; ONO Shin-ichi
Annual Meeting of the Japanese Society of Toxicology, Jun. 2019, Not refereed, Not invited - ヒト子宮頸部扁平上皮病変(CSIL)における細胞周期調節因子p27Kip1発現の免疫組織化学的検討
笠井佑美; 安宅菜月; 徳田栄一; 瀬津弘順; 井上正久
日本薬学会年会, Mar. 2019, Not refereed, Not invited - 横紋筋融解症に伴う急性尿細管障害に対するEdaravone反復投与の影響
仙石瞳友; 廣瀬陽美; 前田紗希; 徳田栄一; 瀬津弘順; 井上正久
日本薬学会年, Mar. 2019, Not refereed, Not invited - ALSモデルマウスにおけるアクアポリン4欠損は異常タンパク質蓄積と病態進行を加速させる
設樂周聖; 渡辺(松本)さおり; 廣瀬美嘉子; 山中宏二; 阿部陽一郎; 安井正人; 徳田栄一; 古川良明; 三澤日出巳
日本薬理学雑誌, 2019 - 銅シャペロンCCSによるSOD1タンパク質への金属イオン供給メカニズム
羽飼友昭; 福岡真実; 徳田栄一; 徳田栄一; 古川良明
メタルバイオサイエンス研究会2018, Nov. 2018, Not refereed, Not invited - 筋萎縮性側索硬化症(Amyotrophic Lateral Sclerosis;ALS)とCu,Zn,そしてmisfolding
小野真一; 徳田栄一
メタルバイオサイエンス研究会2018, Nov. 2018, Not refereed, Not invited - バクテリアにおけるSodC‐IIタンパク質の「抗老化」機能
吉田昂生; 徳田栄一; 徳田栄一; 古川良明
メタロバイオサイエンス研究会2018, Nov. 2018, Not refereed, Not invited - 酸化ストレスが引き起こす銅・亜鉛スーパーオキシドディスムターゼのミスフォールディング機構
古川良明; 安齋樹; 徳田栄一; 徳田栄一; 向山厚; 秋山修志
メタルバイオサイエンス研究会2018, Nov. 2018, Not refereed, Not invited - ALS原因タンパク質であるSOD1の線維化やゲル化には適度な水分子を含む伸びた中間体が必要である
藤原範子; 我妻美千留; 大場矢登; 吉原大作; 徳田栄一; 江口裕伸; 崎山晴彦; 井上正志; 古川良明; 鈴木敬一郎
日本生化学会大会(Web), Sep. 2018, Not refereed, Not invited - 筋萎縮性側索硬化症に見られるSOD1タンパク質の凝集を抑制するメカニズム
松本響佳; 中村滉平; 徳田栄一; 古川良明
日本蛋白質科学会年会プログラム・要旨集, 23 May 2018, Not refereed, Not invited - システイン残基の酸化が促進するSOD1タンパク質のミスフォールディング
安齋樹; 徳田栄一; 古川良明
日本蛋白質科学会年会プログラム・要旨集, 23 May 2018, Not refereed, Not invited - SOD1タンパク質への銅イオン供給に金属シャペロンCCSが果たす役割
羽飼友昭; 福岡真実; 徳田栄一; 古川良明
日本蛋白質科学会年会プログラム・要旨集, 23 May 2018, Not refereed, Not invited - 運動ニューロン疾患ALSにおけるミスフォールドタンパク質のプリオン様特性:現状と今後の展望
徳田栄一; MAKLUND Stefan; 古川良明
日本薬学会年会要旨集(CD-ROM), 2018, Not refereed, Not invited - 神経変性疾患ALSの病初期に現れる銅イオン欠乏型SOD1
徳田栄一; 大原慎司; 山中宏二; 三澤日出巳; 古川良明
メタルバイオサイエンス研究会講演要旨集, 13 Oct. 2017, Not refereed, Not invited - タンパク質の構造異常を検出できるファージの開発と神経変性疾患の病理解明への応用
古川良明; 徳田栄一; 長澤健一; 野村尚生; 山中宏二; 三澤日出巳; 大原慎司
生体分子科学討論会講演要旨集, 23 Jun. 2017, Not refereed, Not invited - 神経変性疾患の発症に関わるタンパク質のミスフォールディングを抑制する化合物の探索
半田純夏; 徳田栄一; 古川良明
日本化学会春季年会講演予稿集(CD-ROM), 03 Mar. 2017, Not refereed, Not invited - 神経変性疾患に関連したタンパク質の線維化を抑制する化合物の探索
中村滉平; 徳田栄一; 古川良明
日本化学会春季年会講演予稿集(CD-ROM), 03 Mar. 2017, Not refereed, Not invited - 筋萎縮性側索硬化症にみられる変異型SOD1への金属イオン結合の異常
古川良明; 徳田栄一; 大原慎司; 山中宏二; 三澤日出巳
日本生化学会大会(Web), 2017, Not refereed, Not invited - 筋萎縮性側索硬化症における変異SOD1オリゴマーの免疫化学的な検出
徳田栄一; 森崎祐太; 三澤日出巳; 渡邊征爾; 山中宏二; 大原慎司; 古川良明
日本薬学会年会要旨集(CD-ROM), 2017, Not refereed, Not invited - A Mechanism on the Pathological Formation of Toxic Protein Oligomers in the Neurodegenerative Disease
ANZAI Itsuki; TOKUDA Eiichi; MUKAIYAMA Atsushi; AKIYAMA Shuji; FURUKAWA Yoshiaki
日本化学会春季年会講演予稿集(CD-ROM), 2017 - 免疫化学的手法を利用した神経変性疾患関連タンパク質の構造変化解明
古川良明; 徳田栄一; 大原慎司; 三澤日出巳; 山中宏二
生体分子科学討論会講演要旨集, 24 Jun. 2016, Not refereed, Not invited - 神経変性疾患の治療法開発を目指したミスフォールドタンパク質認識ペプチドの作製
古川良明; 長澤健一; 徳田栄一; 野村尚生
日本蛋白質科学会年会プログラム・要旨集, 19 May 2016, Not refereed, Not invited - 銅・亜鉛スーパーオキサイドディスムターゼの金属イオン結合状態を識別できる新規抗体の開発と筋萎縮性側索硬化症の病理解明への応用
徳田栄一; 森崎佑太; 三澤日出巳; 渡邊征爾; 山中宏二; 大原慎司; 古川良明
日本薬学会年会要旨集(CD-ROM), 2016, Not refereed, Not invited - 細胞内Cu恒常性破綻はALS関連SOD1変異に共通した病態機序である
徳田栄一; 大川枝里子; 渡辺俊輔; MARKLUND Stefan L; 小野真一
メタルバイオサイエンス研究会講演要旨集, 27 Aug. 2015, Not refereed, Not invited - 筋萎縮性側策硬化症マウスにおける変異SOD1とglutaredoxinの検討
小野真一; 安田あずさ; 徳田栄一
日本神経学会学術大会プログラム・抄録集, 2013, Not refereed, Not invited - Cu結合たん白質メタロチオネイン‐Iは進行期のALSモデルマウスに奏効する
小野真一; 徳田栄一
日本神経学会総会プログラム・抄録集, 2010, Not refereed, Not invited - Metallothionein誘導は筋萎縮性側索硬化症マウスの運動ニューロン死を抑制し,ALS様症状を改善する
徳田栄一; 渡辺俊輔; 大川枝里子; 鈴木孝; 内倉和雄; 小野真一
神経治療学, 25 May 2009, Not refereed, Not invited - Amyotrophic lateral sclerosis ; ALS
小野真一; 徳田栄一
薬局, 24 Mar. 2009, Not refereed, Not invited - 変異Cu/Zn superoxide dismutaseは家族性筋萎縮性側索硬化症モデルマウスでCu輸送障害を引き起こす
大川枝里子; 徳田栄一; 伊藤芳久; 鈴木孝; 小野真一
日本薬学会年会要旨集, 05 Mar. 2009, Not refereed, Not invited - 銅キレート剤ammonium tetrathiomolybdateは筋萎縮性側索硬化症マウスの生存期間を延長し,運動ニューロン変性を抑制する
徳田栄一; 大川枝里子; 伊藤芳久; 鈴木孝; 小野真一
日本薬学会年会要旨集, 05 Mar. 2009, Not refereed, Not invited - 外因性metallothionein‐Iは筋萎縮性側索硬化症マウスのALS様症状に奏効する
徳田栄一; 鈴木孝; 小野真一
日本大学薬学部学術講演会講演要旨集, 2009, Not refereed, Not invited - 変異SOD1はCu排泄トランスポーターAtp7aを凝集体成分にし,Cu排泄障害を引き起こす
徳田栄一; 大川枝里子; 小野真一
日本神経学会総会プログラム・抄録集, 2009, Not refereed, Not invited - 筋萎縮性側索硬化症の病態解明と新規治療薬開発をめざして
伊藤芳久; 小菅康弘; 徳田栄一; 宮岸寛子; 小野真一; 鈴木孝; 石毛久美子; 吉川正信; 橋本篤司
生体機能と創薬シンポジウム要旨集, 01 Sep. 2008, Not refereed, Not invited - 筋萎縮性側索硬化症の新規治療戦略~メタロチオネイン誘導がALS症状を改善する~
渡辺俊輔; 徳田栄一; 大川枝里子; 伊藤芳久; 鈴木孝; 小野真一
日本薬学会年会要旨集, 05 Mar. 2008, Not refereed, Not invited - プロテオーム情報に基づく筋萎縮性側索硬化症の創薬戦略:細胞内の銅不均衡をターゲットとした創薬
徳田栄一; 小野真一; 石毛久美子; 伊藤芳久; 鈴木孝
日本薬学会年会要旨集, 05 Mar. 2008, Not refereed, Not invited - 家族性ALSの背景に銅輸送体たん白質の異常が存在する
大川枝里子; 徳田栄一; 石毛久美子; 伊藤芳久; 鈴木孝; 小野真一
日本神経学会総会プログラム・抄録集, 2008, Not refereed, Not invited - 変異Cu/Zn superoxide dismutaseは脊髄Cu輸送障害を引き起こす
大川枝里子; 徳田栄一; 伊藤芳久; 鈴木孝; 小野真一
日本大学薬学部学術講演会講演要旨集, 2008, Not refereed, Not invited - Metallothionein‐I/II誘導はマウスのALS様症状を改善する
渡辺俊輔; 徳田栄一; 小野真一
日本神経学会総会プログラム・抄録集, 2008, Not refereed, Not invited - 銅キレート剤ammonium tetrathiomolybdateは麻痺を呈した筋萎縮性側索硬化症マウスのALS様症状を改善する
徳田栄一; 大川枝里子; 伊藤芳久; 鈴木孝; 小野真一
日本大学薬学部学術講演会講演要旨集, 2008, Not refereed, Not invited - Toward better understanding motor neuron death and designing a new drug for amyotrophic lateral sclerosis
Yoshihisa Ito; Yasuhiro Kosuge; Eiichi Tokuda; Hiroko Miyagishi; Shin-ichi Ono; Takashi Suzuki; Kuniko Ishige; Masanobu Yoshikawa; Atsushi Hashimoto
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, Not refereed, Not invited - ミトコンドリアDNAの酸化損傷は筋萎縮性側索硬化症の運動麻痺発症に関与する
徳田栄一; 小野真一; 石毛久美子; 伊藤芳久; 鈴木孝
日本薬学会年会要旨集, 05 Mar. 2007, Not refereed, Not invited - 筋萎縮性側索硬化症における新規治療戦略メタロチオネイン誘導による治療効果の検討
渡辺俊輔; 徳田栄一; 伊藤芳久; 石毛久美子; 鈴木孝; 小野真一
日本大学薬学部学術講演会講演要旨集, 2007, Not refereed, Not invited - 銅キレート剤テトラチオモリブデン酸はALSモデルマウスの生存を延長する
徳田栄一; 小野真一; 石毛久美子; 渡辺俊輔; 大川枝里子; 伊藤芳久; 鈴木孝
日本神経学会総会プログラム・抄録集, 2007, Not refereed, Not invited - Metallothionein‐I overexpressing筋萎縮性側索硬化症マウスは生存期間が短縮する
徳田栄一; 小野真一; 小菅康弘; 石毛久美子; 伊藤芳久; 鈴木孝
日本大学薬学部学術講演会講演要旨集, 2007, Not refereed, Not invited - 筋萎縮性側索硬化症モデルマウスにおける銅輸送体たん白質の検討
大川枝里子; 徳田栄一; 石毛久美子; 伊藤芳久; 鈴木孝; 小野真一
日本大学薬学部学術講演会講演要旨集, 2007, Not refereed, Not invited - 筋萎縮性側索硬化症における新規治療の可能性:メタロチオネインによるアポトーシス均衡の破綻および脂質過酸化の是正
徳田栄一; 小野真一; 石毛久美子; 伊藤芳久; 永沼章; 鈴木孝
日本薬学会年会要旨集, 06 Mar. 2006, Not refereed, Not invited - ALSの運動ニューロン死に対するメタロチオネインの防御効果
徳田栄一; 小野真一; 石毛久美子; 伊藤芳久; 永沼章; 鈴木孝
日本神経学会総会プログラム・抄録集, 2006, Not refereed, Not invited - Cuキレート剤テトラチオモリブデン酸は筋萎縮性側索硬化症モデルマウスの生存を延長する
徳田栄一; 小野真一; 渡辺俊輔; 大川枝里子; 石毛久美子; 伊藤芳久; 鈴木孝
日本大学薬学部学術講演会講演要旨集, 2006, Not refereed, Not invited - Pergolide mesilateが線条体metallothionein誘導と過酸化脂質生成量に及ぼす影響
小野真一; 徳田栄一; 平井浩一; 鈴木孝
神経治療学, 25 May 2005, Not refereed, Not invited
Books and other publications
- Brain Diseases and Metalloproteins
Eiichi Tokuda, Joint work, Chapter 11. An attempt to treat amyotrophic lateral sclerosis by intracellular copper modification using ammonium tetrathiomolybdate and/or metallothionein: fundamentals and perspective.
Pan Stanford Publishing, Jul. 2012, Not refereed
9789814316019 - Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.
Joint work, Furukawa Y, Tokuda E
Springer, 2017, Refereed
0065-2598 - Amyotrophic lateral sclerosis ; ALS
Joint work, Ono S, Tokuda E.
Nanzan-do Publishing, 24 Mar. 2009
0044-0035 - Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.
Joint work, Furukawa Y, Tokuda E
Springer, 2017, Refereed
0065-2598 - Amyotrophic lateral sclerosis ; ALS
Joint work, Ono S, Tokuda E.
Nanzan-do Publishing, 24 Mar. 2009
0044-0035 - Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.
Joint work, Furukawa Y, Tokuda E
Springer, 2017, Refereed
0065-2598 - Amyotrophic lateral sclerosis ; ALS
Joint work, Ono S, Tokuda E.
Nanzan-do Publishing, 24 Mar. 2009
0044-0035
Lectures, oral presentations, etc.
- Neuroprotection of metallothionein in ALS-SOD1 is mediated by an endocytic receptor LRP2/Megalin
Eiichi Tokuda
1st International Symposium on Metal in ALS, Mar. 2019, Invited - Wild-type SOD1 is misfolded in cerebrospinal fluid of sporadic ALS
Eiichi Tokuda
29th International Symposium on ALS/MND., Dec. 2018, Not invited - Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis
Eiichi Tokuda
28th International Symposium on ALS/MND, Dec. 2017, Not invited - In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates
Eiichi Tokuda
27th International Symposium on ALS/MND., Dec. 2016, Not invited - Human spinal ventral horn contains a lower autophagic capacity than other CNS areas: Implication for selective vulnerability of motor system in ALS
Eiichi Tokuda
26th International Symposium on ALS/MND, Dec. 2015, Not invited - Co-expression of strain A- and B-aggregate forming human SOD1 mutants in mice: studies of aggregate structure and disease phenotype
Eiichi Tokuda
25th International Symposium on ALS/MND, Dec. 2014, Not invited - Impairment of autophagy exacerbates disease courses accompanied by accumulation of superoxide dismutase-1 aggregates in a mouse model of amyotrophic lateral sclerosis
Eiichi Tokuda
5th Scandinavia Symposium on Amyloid Disease and Amyloid Mechanisms., Oct. 2014, Invited - The effects of metabolic disturbances on the level of misfolded SOD1 in ALS patient-derived fibroblast lines
Eiichi Tokuda
12th European Network for Cure of ALS, May 2014, Not invited - Overexpression of human wild-type SOD1 hastens disease onset and induces earlier presence of mutant SOD1 aggregates in a mouse model of ALS
Eiichi Tokuda
24th International Symposium on ALS/MND, Dec. 2013, Not invited - Reduction in the autophagy protein, Beclin 1, accelerates disease progression and leads to accumulation of mutant SOD1 aggregates in a mouse model of ALS
Eiichi Tokuda
23rd International Symposium on ALS/MND, Dec. 2012, Not invited - Dysregulation of intracellular copper homeostasis is common for dismutase active and inactive form of SOD1 mutants
Eiichi Tokuda
22nd International Symposium on ALS/MND, Nov. 2011, Not invited - “Dysregulation of intracellular copper homeostasis is common for dismutase active and inactive form of SOD1 mutants
Eiichi Tokuda
9th European Network for Cure of ALS, May 2011, Not invited - Administration of recombinant metallothionein-I starting at onset prolongs survival in a mouse model of mutant SOD1-linked familial ALS
Eiichi Tokuda
21st International Symposium on ALS/MND, Dec. 2010, Not invited - Overexpression of glial metallothionein slows disease progression in a mouse model of mutant SOD1-linked familial ALS
Eiichi Tokuda
20th International Symposium on ALS/MND, Dec. 2009, Not invited - Ammonium tetrathiomolybdate, a copper-chelating drug, suppresses superoxide dismutase-1 aggregation and has therapeutic effects in a mouse model of amyotrophic lateral scleros
Eiichi Tokuda
19th International Symposium on ALS/MND, Nov. 2008, Not invited - Metallothionein-I serves a protective function in amyotrophic lateral sclerosis
Eiichi Tokuda
11th International Congress of Toxicology, Jul. 2007, Not invited - Zinc-binding metallothionein inhibits the SOD1 aggregation via binding of core regions for aggregate growth
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Yasuhiro Kosuge, Shin-ichi Ono
Neuro2022 (The 45th Annual Meeting of the Japan Neuroscience Society), 30 Jun. 2022, Not invited - Zn-binding metallothionein inhibits the aggregation of a pathogenic protein linked to amyotrophic lateral sclerosis
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Yasuhiro Kosuge, Shin-ichi Ono
142th Annual Meeting of the Pharmaceutical Society of Japan, 26 Mar. 2022, Not invited - Metallothionein as a therapeutic target for ALS: inhibition of ALS-linked protein aggregates
Eiichi Tokuda
1st Symposium for Collaboration with Industry-government-academia. Innovation Network in Chiba., 03 Mar. 2022, Chiba University, Innovation Management Organization, Invited
https://imo.chiba-u.jp/news/event/chiba-inet.html - A conformational feature of extracellular misfolded SOD1 with prion-like properties in the extracellular environment surrounding motor neuron-like cells
Eiichi Tokuda, Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, Shin-ichi Ono
The 44th Annual Meeting of the Japan Neuroscience Society, 31 Jul. 2021, Not invited - Metallothionein-I protects against pathological aggregation of SOD1 associated with amyotrophic lateral sclerosis
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Shin-ichi Ono
The 48th Annual Meeting of the Japanese Society of Toxicology, 09 Jul. 2021, Invited - A molecular pathway for cell-to-cell transmission of ALS-linked protein aggregates is common to the aggregates with different conformations
Eiichi Tokuda, Miho Tagami, Stefan L. Marklund, Shin-ichi Ono.
141th Annual Meeting of the Pharmaceutical Society of Japan, 28 Mar. 2021, Not invited - Zinc-binding metallothionein inhibits the SOD1 aggregation via binding of core regions for aggregate growth
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Yasuhiro Kosuge, Shin-ichi Ono
Neuro2022 (The 45th Annual Meeting of the Japan Neuroscience Society), 30 Jun. 2022, Not invited - Zn-binding metallothionein inhibits the aggregation of a pathogenic protein linked to amyotrophic lateral sclerosis
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Yasuhiro Kosuge, Shin-ichi Ono
142th Annual Meeting of the Pharmaceutical Society of Japan, 26 Mar. 2022, Not invited - Metallothionein as a therapeutic target for ALS: inhibition of ALS-linked protein aggregates
Eiichi Tokuda
1st Symposium for Collaboration with Industry-government-academia. Innovation Network in Chiba., 03 Mar. 2022, Chiba University, Innovation Management Organization, Invited
https://imo.chiba-u.jp/news/event/chiba-inet.html - A conformational feature of extracellular misfolded SOD1 with prion-like properties in the extracellular environment surrounding motor neuron-like cells
Eiichi Tokuda, Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, Shin-ichi Ono
The 44th Annual Meeting of the Japan Neuroscience Society, 31 Jul. 2021, Not invited - Metallothionein-I protects against pathological aggregation of SOD1 associated with amyotrophic lateral sclerosis
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Shin-ichi Ono
The 48th Annual Meeting of the Japanese Society of Toxicology, 09 Jul. 2021, Invited - A molecular pathway for cell-to-cell transmission of ALS-linked protein aggregates is common to the aggregates with different conformations
Eiichi Tokuda, Miho Tagami, Stefan L. Marklund, Shin-ichi Ono.
141th Annual Meeting of the Pharmaceutical Society of Japan, 28 Mar. 2021, Not invited - Zinc-binding metallothionein inhibits the SOD1 aggregation via binding of core regions for aggregate growth
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Yasuhiro Kosuge, Shin-ichi Ono
Neuro2022 (The 45th Annual Meeting of the Japan Neuroscience Society), 30 Jun. 2022, Not invited - Zn-binding metallothionein inhibits the aggregation of a pathogenic protein linked to amyotrophic lateral sclerosis
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Yasuhiro Kosuge, Shin-ichi Ono
142th Annual Meeting of the Pharmaceutical Society of Japan, 26 Mar. 2022, Not invited - Metallothionein as a therapeutic target for ALS: inhibition of ALS-linked protein aggregates
Eiichi Tokuda
1st Symposium for Collaboration with Industry-government-academia. Innovation Network in Chiba., 03 Mar. 2022, Chiba University, Innovation Management Organization, Invited
https://imo.chiba-u.jp/news/event/chiba-inet.html - A conformational feature of extracellular misfolded SOD1 with prion-like properties in the extracellular environment surrounding motor neuron-like cells
Eiichi Tokuda, Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, Shin-ichi Ono
The 44th Annual Meeting of the Japan Neuroscience Society, 31 Jul. 2021, Not invited - Metallothionein-I protects against pathological aggregation of SOD1 associated with amyotrophic lateral sclerosis
Eiichi Tokuda, Maiko Keima, Chiako Ikeda, Shin-ichi Ono
The 48th Annual Meeting of the Japanese Society of Toxicology, 09 Jul. 2021, Invited - A molecular pathway for cell-to-cell transmission of ALS-linked protein aggregates is common to the aggregates with different conformations
Eiichi Tokuda, Miho Tagami, Stefan L. Marklund, Shin-ichi Ono.
141th Annual Meeting of the Pharmaceutical Society of Japan, 28 Mar. 2021, Not invited - Nov. 2020, Not invited
- Distinct influences of ALS-linked SOD1 mutants on endocytosis: implication of strain type of SOD1 aggregates
Eiichi Tokuda, Miho Tagami, Rieko Fujiwara, Asuka Eguchi, Stefan L. Marklund, Shin-ichi Ono
The 43rd Annual Meeting of the Japan Neuroscience Society, Jul. 2020, Not invited - Extracellular misfolded SOD1 is toxic to motor neurons: Implication of endocytic dysfunction for the pathology of amyotrophic lateral sclerosis
Eiichi Tokuda, Chika Takashima, Miho Tagami, Shin-ichi Ono
140th Annual Meeting of the Pharmaceutical Society of Japan, Mar. 2020, Not invited - Dec. 2019, Not invited
- Oct. 2019, Not invited
- Oct. 2019, Not invited
- Jun. 2019, Not invited
- Mar. 2019, Not invited
- Mar. 2019
- Nov. 2020, Not invited
- Distinct influences of ALS-linked SOD1 mutants on endocytosis: implication of strain type of SOD1 aggregates
Eiichi Tokuda, Miho Tagami, Rieko Fujiwara, Asuka Eguchi, Stefan L. Marklund, Shin-ichi Ono
The 43rd Annual Meeting of the Japan Neuroscience Society, Jul. 2020, Not invited - Extracellular misfolded SOD1 is toxic to motor neurons: Implication of endocytic dysfunction for the pathology of amyotrophic lateral sclerosis
Eiichi Tokuda, Chika Takashima, Miho Tagami, Shin-ichi Ono
140th Annual Meeting of the Pharmaceutical Society of Japan, Mar. 2020, Not invited - Dec. 2019, Not invited
- Oct. 2019, Not invited
- Oct. 2019, Not invited
- Jun. 2019, Not invited
- Mar. 2019, Not invited
- Mar. 2019
- Nov. 2020, Not invited
- Distinct influences of ALS-linked SOD1 mutants on endocytosis: implication of strain type of SOD1 aggregates
Eiichi Tokuda, Miho Tagami, Rieko Fujiwara, Asuka Eguchi, Stefan L. Marklund, Shin-ichi Ono
The 43rd Annual Meeting of the Japan Neuroscience Society, Jul. 2020, Not invited - Extracellular misfolded SOD1 is toxic to motor neurons: Implication of endocytic dysfunction for the pathology of amyotrophic lateral sclerosis
Eiichi Tokuda, Chika Takashima, Miho Tagami, Shin-ichi Ono
140th Annual Meeting of the Pharmaceutical Society of Japan, Mar. 2020, Not invited - Dec. 2019, Not invited
- Oct. 2019, Not invited
- Oct. 2019, Not invited
- Jun. 2019, Not invited
- Mar. 2019, Not invited
- Mar. 2019
Courses
- Disorders & Pharmacotherapies III
Apr. 2023 - Present
School of Pharmacy, Nihon University - Pretraining for Pharmaceutical Practice II
Sep. 2019 - Present
School of Pharmacy, Nihon University - Apr. 2019 - Present
- English V
Apr. 2019 - Present
School of Pharmacy, Nihon University - Apr. 2019 - Jul. 2022
- Sep. 2018 - Mar. 2019
- Apr. 2018 - Jul. 2018
- Apr. 2015 - Jul. 2017
Affiliated academic society
Research Themes
- Research on the pathogenesis of Alzhiemer's disease based on the novel stoichometrical molecular analyses in intracellular micro-regions.
Nihon University, Research Grant, Apr. 2024 - Mar. 2026
Tomohiro Miyasaka; Eiichi Tokuda; Hiroko Miyagishi; Toru Tanaka - Understating of disease process for ALS from the viewpoint of endosomal pH regulation.
The Takeda Science Foundation, Research Grant for Pharmaceutical Sciences, Nov. 2022 - May 2025
Eiichi Tokuda - Establishment of a principle that can entrap protein aggregates with cell-to-cell transmission inside the cells
The Ichiro Kanehara Foundation, Research Grant for Basic Medical Studies, Nov. 2023 - Oct. 2024
Eiichi Tokuda - How does endosome contributes to the pathogenesis of protein conformational diseases?
Nihon University, Grant for Collaborative Research, Apr. 2023 - Mar. 2024
Eiichi Tokuda; Toru Tanaka - Search for the Hofmeister series ions that facilitate the aggregation of ALS related proteins and their application for ALS diagnosis
The Yukihiko Miyata Memorial Trust for ALS Research, Grant-in-Aid, Sep. 2022 - Sep. 2023
Eiichi Tokuda - Development of hemodiagnosis for amyotrophic lateral sclerosis based on seeding reaction of misfolded protein
JSPS, Grant-in-Aid for Challenging Exploratory Research, Jul. 2021 - Mar. 2023
Eiichi Tokuda - Are protein aggregate strains associated with phenotypic diversity of ALS?
The Hamaguchi Foundation for the Advancement of Biochemistry, Research Grant, Jan. 2022 - Jan. 2023
Eiichi Tokuda - Cell-to-cell transmission of ALS-related protein aggregates that initially spread from endosomes
The Serika Fund, Research Grant for ALS Research, Dec. 2021 - Dec. 2022
Eiichi Tokuda - Understanding of cell-to-cell spread of ALS linked-protein aggregates, learning from a theory of proton sponge effect in Drug Delivery Science
Nihon University, Grant-in-Aid for Young Scientists, Oct. 2021 - Mar. 2022 - Development of hemodiagnosis for amyotrophic lateral sclerosis based on seeding reaction of misfolded protein
Nihon University, Grant-in-Aid for Research Promotion, Apr. 2021 - Mar. 2022
Eiichi Tokuda - Does an endocytic receptor LRP2 regulate cell-to-cell transmission of SOD1 aggregates?
The Japan ALS Association, Research Grant for ALS Research, Apr. 2021 - Mar. 2022
Eiichi Tokuda - Therapeutic strategy for ALS targeting interaction between an endocytic receptor LRP2 and SOD1 aggregates
Mochida Memorial Foundation for Medical and Pharmaceutical Research, Research Grant, Dec. 2020 - Dec. 2021
Eiichi Tokuda - Development of blood diagnosis for ALS based on seeding reaction of misfolded proteins
YOKOYAMA Foundation for Clinical Pharmacology, Grant-in-Aid, Oct. 2020 - Jun. 2021
Eiichi Tokuda - Development of a proteome approach that comprehensively detects factors interacting with prion-like protein aggregates
Inohana Foundation, Research Grant, Jul. 2020 - Jun. 2021
Eiichi Tokuda - Search for endocytosis inducers that are capable of efficiently removing extracellular misfoldded proteins
The Pharmacological Research Foundation, Tokyo, Research Grant, Sep. 2019 - Oct. 2020
Eiichi Tokuda - The role of cross-seeding in the pathogenesis of neurodegenerative diseases
JSPS, Grant-in-Aid for Young Scientists, Apr. 2017 - Mar. 2019
Eiichi Tokuda - Amylodosis potentially elicited by medicines: risk factor of development of neurodegenerative diseases?
Mizuho Foundation for the Promotion of Sciences, Grant-in-Aid, Apr. 2016 - Mar. 2018
Eiichi Tokuda - Study on molecular mechanisms that accelerates the disease process of neurodegenerative diseases
JSPS, Grant-in-Aid for Research Activity Start-Up, Aug. 2015 - Mar. 2017
Eiichi Tokuda - Development of C. elegans models for study on disease progression of Parkinson's disease
KLL, 次世代先端分野探索研究, Apr. 2015 - Mar. 2016
Eiichi Tokuda - 神経変性疾患の病態拡大を評価できる新しいモデル動物の構築
Keio Engineering Foundation, Grant-in-Aid, Apr. 2015 - Mar. 2016
Eiichi Tokuda - 神経変性疾患の病態が拡大・伝播する分子メカニズムの解明
慶應義塾大学, 学事振興資金, Apr. 2015 - Mar. 2016
徳田 栄一 - 筋萎縮性側索硬化症の病態伝播メカニズムを解明するための新たな線虫モデルの確立
Sumitomo Mitsui Trust Bank, Limited, Research Grant for ALS Research, Apr. 2015 - Mar. 2016
Eiichi Tokuda - 新規の線虫モデルを利用したALS病態伝播メカニズムの検証
Japan ALS Association, Grant-in-Aid for ALS Research, Apr. 2015 - Mar. 2016
Eiichi Tokuda - Dose extracellular SOD3 have a protective effect against vascular damage seen in ALS?
The Naito Foundation, Grant-in-Aid for Overseas Fellowship, Apr. 2010 - Mar. 2011
Eiichi Tokuda - Development of novel therapies for amyotrophic lateral sclerosis
JSPS, Grant-in-Aid for JSPS Fellow, Apr. 2008 - Mar. 2010
Eiichi Tokuda
Industrial Property Rights
Academic Contribution Activities
- Topical Advisory Panel: International Journal of Molecular Sciences
Planning etc
International Journal of Molecular Sciences, Jun. 2022 - Present - NISTEP専門調査員
Academic research planning
文部科学省 科学技術・学術政策研究所科学技術予測センター, Sep. 2021 - Present - Advisory Board: Life（MDPI, Switzerland）
Planning etc
Life, MDPI, Jan. 2020 - Present
