YAMAGUCHI Takuya
| College of Bioresource Sciences Department of Veterinary Medicine | Assistant Professor |
Researcher Information
Degree
Field Of Study
Career
- Apr. 2024 - Present
Nihon University, College of Bioresource Sciences Department of Veterinary Medicine, Assistant Professor - Apr. 2021 - Mar. 2024
Nihon University, College of Bioresource Sciences, Department of Veterinary Medicine, Assistant Professor - May 2019 - Mar. 2021
Central Institute for Experimental Animals, 研究員 - Apr. 2013 - Apr. 2019
Friedrich-Loeffler-Institut, postdoc - Apr. 2010 - Mar. 2013
Nihon University, College of Bioresource Sciences, リサーチ・アシスタント - Apr. 2009 - Mar. 2010
Nihon University, College of Bioresource Sciences, ティーチング・アシスタント
Research activity information
Award
- The Japanese Association for Developmental and Comparative Immunology, Furuta Excellent Paper Award
Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response
Takuya Yamaguchi, Chia Jung Chang, Axel Karger, Markus Keller, Florian Pfaff, Eakapol Wangkahart, Tiehui Wang, Christopher J. Secombes, Azusa Kimoto, Mitsuru Furihata, Keiichiro Hashimoto, Uwe Fischer, Johannes M. Dijkstra - 独立行政法人日本学生支援機構, 特に優れた業績による返還免除（第一種奨学金・全額返還免除）
Others
山口 卓哉
第一種奨学金の全額返還免除 - Jan. 2013
第2回 日本大学幹細胞研究フォーラム, 優秀演題賞
クローン化 T 細胞株を用いたコイ Th2 細胞の同定
山口 卓哉 - 12th ISDCI, Honorable Mention Award for student oral presentation
Takuya Yamaguchi - 日本大学生物資源科学部, 学部特別研究生
山口 卓哉
Paper
- ★Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation
Takuya Yamaguchi; Kunitoshi Uchida; Jun Yamazaki
Journal of Veterinary Medical Science, Dec. 2023, Refereed, Not invited
Lead - ★Generation of Novel Human Red Blood Cell-Bearing Humanized Mouse Models Based on C3-Deficient NOG Mice
Takuya Yamaguchi; Ikumi Katano; Iyo Otsuka; Ryoji Ito; Misa Mochizuki; Motohito Goto; Takeshi Takahashi
Frontiers in Immunology, Jul. 2021, Refereed
Lead - ★Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response
Takuya Yamaguchi; Chia Jung Chang; Axel Karger; Markus Keller; Florian Pfaff; Eakapol Wangkahart; Tiehui Wang; Christopher J. Secombes; Azusa Kimoto; Mitsuru Furihata; Keiichiro Hashimoto; Uwe Fischer; Johannes M. Dijkstra
Frontiers in Immunology, Oct. 2020, Refereed, Not invited
Lead - ★Clonal growth of carp (Cyprinus carpio) T cells in vitro: Long-term proliferation of Th2-like cells
Takuya Yamaguchi; Fumihiko Katakura; Kazue Someya; Johannes Martinus Dijkstra; Tadaaki Moritomo; Teruyuki Nakanishi
FISH & SHELLFISH IMMUNOLOGY, Feb. 2013, Refereed, Not invited
Lead - Subgenomic T cell receptor alpha and delta (TRA/TRD) loci in common carp
Masaharu Okano; Jiro Miyamae; Kohei Sakurai; Takuya Yamaguchi; Ren Uehara; Fumihiko Katakura; Tadaaki Moritomo
Fish & Shellfish Immunology, Feb. 2024, Refereed - Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody.
Ikumi Katano; Asami Hanazawa; Iyo Otsuka; Takuya Yamaguchi; Misa Mochizuki; Kenji Kawai; Ryoji Ito; Motohito Goto; Takahiro Kagawa; Takeshi Takahashi
Scientific reports, Oct. 2021, Refereed - Teleost cytotoxic T cells.
Yamaguchi T; Takizawa F; Furihata M; Soto-Lampe V; Dijkstra JM; Fischer U
Fish & shellfish immunology, Dec. 2019, Refereed, Not invited
Lead - Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish.
Yamaguchi T; Dijkstra JM
Cells, Apr. 2019, Refereed, Not invited
Lead - Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules.
Dijkstra JM; Yamaguchi T
Immunogenetics, Mar. 2019, Refereed, Not invited - New cell lines for efficient propagation of koi herpesvirus and infectious salmon anaemia virus.
Eckart V; Yamaguchi T; Franzke K; Bergmann SM; Boudinot P; Quillet E; Kawanobe M; de Haro NA; Fischer U
Journal of fish diseases, Feb. 2019, Refereed, Not invited - What could be the mechanisms of immunological memory in fish?
Yamaguchi T; Quillet E; Boudinot P; Fischer U
Fish & shellfish immunology, Feb. 2019, Refereed, Not invited
Lead - A Novel Antigen-Sampling Cell in the Teleost Gill Epithelium With the Potential for Direct Antigen Presentation in Mucosal Tissue.
Kato G; Miyazawa H; Nakayama Y; Ikari Y; Kondo H; Yamaguchi T; Sano M; Fischer U
Frontiers in immunology, Sep. 2018, Refereed, Not invited - Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species
Johannes M. Dijkstra; Takuya Yamaguchi; Unni Grimholt
Immunogenetics, Jul. 2018, Refereed, Not invited - Identification of a fourth ancient member of the IL-3/IL-5/GM-CSF cytokine family, KK34, in many mammals
Takuya Yamaguchi; Susann Schares; Uwe Fischer; Johannes M. Dijkstra
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Dec. 2016, Refereed, Not invited
Lead - T cell immunity in the teleost digestive tract
Carolina Tafalla; Esther Leal; Takuya Yamaguchi; Uwe Fischer
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Nov. 2016, Refereed, Not invited - Recombinant carp IL-4/13B stimulates in vitro proliferation of carp IgM(+) B cells
Takuya Yamaguchi; Shunsuke Miyata; Fumihiko Katakura; Takahiro Nagasawa; Yasuhiro Shibasaki; Takeshi Yabu; Uwe Fischer; Chihaya Nakayasu; Teruyuki Nakanishi; Tadaaki Moritomo
FISH & SHELLFISH IMMUNOLOGY, Feb. 2016, Refereed, Not invited
Lead - Exploring erythropoiesis of common carp (Cyprinus carpio) using an in vitro colony assay in the presence of recombinant carp kit ligand A and erythropoietin
Fumihiko Katakura; Takeshi Yabu; Takuya Yamaguchi; Jiro Miyamae; Yuki Shirinashihama; Teruyuki Nakanishi; Tadaaki Moritomo
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Nov. 2015, Refereed, Not invited - Along the axis between type 1 and type 2 immunity; principles conserved in evolution from fish to mammals
Takuya Yamaguchi; Fumio Takizawa; Uwe Fischer; Johannes M. Dijkstra
Biology, Nov. 2015, Refereed, Not invited
Lead - Clonal growth of carp (Cyprinus carpio) T cells in vitro
Takuya Yamaguchi; Fumihiko Katakura; Satoshi Shitanda; Yoshimitsu Niida; Hideaki Toda; Maki Ohtani; Takeshi Yabu; Hiroaki Suetake; Tadaaki Moritomo; Teruyuki Nakanishi
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Feb. 2011, Refereed, Not invited
Lead - Demonstration of T cell and macrophage progenitors in carp (Cyprinus carpio) kidney hematopoietic tissues. Development of clonal assay system for carp hematopoietic cells
Fumihiko Katakura; Takuya Yamaguchi; Miyuki Yoshida; Tadaaki Moritomo; Teruyuki Nakanishi
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Jun. 2010, Refereed, Not invited - Co-culture of carp (Cyprinus carpio) kidney haematopoietic cells with feeder cells resulting in long-term proliferation of T-cell lineages
Fumihiko Katakura; Fumio Takizawa; Miyuki Yoshida; Takuya Yamaguchi; Kyosuke Araki; Mitsuru Tomana; Miki Nakao; Tadaaki Moritomo; Teruyuki Nakanishi
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Sep. 2009, Refereed, Not invited
MISC
- The evolution of IL-2, IL-15 and IL-15L family cytokines; the first report on the function of ancient IL-15L
Johannes M. Dijkstra; Takuya Yamaguchi; Uwe Fischer; Keiichiro Hashimoto
CYTOKINE, Dec. 2017, Refereed, Not invited - ニジマス鰓上皮抗原取込細胞に対するモノクローナル抗体の作出
碇由紀; 市田健介; 山口卓哉; FISCHER Uwe; 佐野元彦; 加藤豪司
日本魚病学会大会プログラムおよび講演要旨, 2017 - ニジマスの鰓上皮抗原取込細胞におけるMHCクラスIIの発現解析
中山裕美子; 山口卓哉; FISCHER Uwe; 佐野元彦; 加藤豪司
日本魚病学会大会プログラムおよび講演要旨, 2017 - Adoptive transfer of immunity against red mouth disease in rainbow trout (Oncorhynchus mykiss)
Takuya Yamaguchi; Uwe Fischer
FISH & SHELLFISH IMMUNOLOGY, Jun. 2016, Refereed, Not invited
Lead - Characterization of antigen sampling cells in rainbow trout gill epithelium
Goshi Kato; Haruya Miyazawa; Takuya Yamaguchi; Hidehiro Kondo; Motohiko Sano; Uwe Fischer
FISH & SHELLFISH IMMUNOLOGY, Jun. 2016, Refereed, Not invited - Demonstration of fish hematopoietic stem/progenitor cells
Tadaaki MORITOMO; Isao KOBAYASHI; Fumihiko KATAKURA; Takuya YAMAGUCHI
Japanese Journal of Thrombosis and Hemostasis, Feb. 2010, Not refereed, Not invited
Books and other publications
Lectures, oral presentations, etc.
- マウスクッパー細胞におけるザイモザン刺激に応答した炎症性サイトカイン遺伝子発現への TRPM2 の役割
水野 真孝; 山口 卓哉; 山﨑 純
第7回 日本獣医薬理学・毒性学会 春季研究会, Mar. 2025, Not invited - The role of TRPM2 in pro-inflammatory cytokine production induced by oxidative stress in murine Kupffer cells
Masataka Mizuno; Takuya Yamaguchi; Jun Yamazaki
Anatomy-Physiology-Pharmacology Week in 2025, Mar. 2025, Not invited - TRPM2を介した過酸化水素によるイヌ末梢血単核球の活性化
山口 卓哉; 上田 直斗; 山﨑 純
第167回日本獣医学会学術集会, Sep. 2024, Not invited - マウスクッパー細胞亜集団における TRP チャネルの発現および機能解析
山口 卓哉; 中山 玲奈; 水野 真孝; 山﨑 純
日本薬理学会第150回関東部会, Jun. 2024, Not invited - TRPM2 はマウス肝マクロファージにおける炎症性サイトカインの遺伝子発現に関わる
水野真孝; 中山玲奈; 山口卓哉; 山﨑純
第6回 日本獣医薬理学・毒性学会 春季研究会 2023年3月11日, Mar. 2024 - Characterization of TRPM2 in canine peripheral blood mononuclear cells
Naoto Ueda; Takuya Yamaguchi; Jun Yamazaki
The 97th Annual Meeting of the Japanese Pharmacological Society, Dec. 2023, Not invited - 冷刺激に対するイヌ、マウスおよびヒトの TRPA1 チャネル応答性
山口 卓哉; 山﨑 純
第166回日本獣医学会学術集会, Sep. 2023 - イヌの末梢血単核球に発現する TRPM2 の性状解析
上田 直斗; 山口 卓哉; 山﨑 純
第5回 日本獣医薬理学・毒性学会 春季研究会, Mar. 2023 - イヌTRPV1変異体が生むチャネル機能の多様性
安藤 楓; 山口 卓哉; 山﨑 純
第5回 日本獣医薬理学・毒性学会 春季研究会, Mar. 2023 - マウスクッパー細胞亜集団における TRP チャネル遺伝子の発現解析
中山 玲奈; 山口 卓哉; 山﨑 純
第5回 日本獣医薬理学・毒性学会 春季研究会, Mar. 2023 - イヌTRPM8とTRPA1 のメントールに対する反応性の違い
山口 卓哉; 柳川 日向子; 松岡 彩那; 内田 邦敏; 山﨑 純
第96回日本薬理学会年会, Dec. 2022, Not invited - イヌTRPM8とTRPA1に対するメントールの反応性の違い
山口 卓哉; 柳川 日向子; 松岡 彩那; 山﨑 純
第165回日本獣医学会, Sep. 2022, Not invited - Reactivity of TRPA1 to menthol differs between mouse and dog
Takuya Yamaguchi; Ayana Matsuoka; Kunitoshi Uchida; Jun Yamazaki
The 95th Annual Meeting of the Japanese Pharmacological Society, Mar. 2022, Not invited - Improved engraftment of human red blood cells in C3-deficient NOG mouse treated with gadolinium chloride
Takuya Yamaguchi
4th Annual HuNIT Platform Virtual Symposium, Dec. 2020, Not invited - Harnessing Interleukin 2 Family Power in Rainbow Trout
Takuya Yamaguchi
TUMSAT Mini Symposium Cell-Mediated Immunity and Infectious diseases in Fish, Mar. 2018, Invited - Contrasting reactivity of CD8alpha-positive and -negative lymphocytes to IL-2 family cytokines in rainbow trout lymphoid tissues
Yamaguchi T; Dijkstra JM; Fischer U
18th International Conference on Diseases of Fish and Shellfish, Sep. 2017, Not invited - First demonstration of CD8alpha+CD8beta+ and CD8alpha+CD8beta- cells in a teleost
Yamaguchi T; Takizawa F; Fischer U
13th Congress of the International Society of Developmental and Comparative Immunology, Jun. 2015 - Characterization of IL-15like molecules in rainbow trout and bovine
Yamaguchi T; Dijkstra JM; Fischer U
13th Congress of the International Society of Developmental and Comparative Immunology, Jun. 2015 - Clonal culture of carp Th2-like cells whose immune status is hallmarked by IL-4/13B gene expression
Yamaguchi T; Katakura F; Someya K; Yabu T; Dijkstra JM; Moritomo T; Nakanishi T
12th Congress of the International Society of Developmental and Comparative Immunology, Jul. 2012, Not invited - Long-term proliferation of common carp (Cyprinus carpio) CD4+ T-cells in culture
Yamaguchi T; Katakura F; Yoshida M; Ohtani M; Moritomo T; Nakanishi T
11th Congress of the International Society of Developmental and Comparative Immunology, Jul. 2009, Not invited
Research Themes
- マウスクッパー細胞の機能制御におけるTRPVおよびTRPMチャネルファミリーの役割
日本学術振興会, 科学研究費助成事業, Apr. 2023 - Mar. 2026
山口 卓哉 - TRP チャネルを介して単球や単球由来マクロファージを調節し、炎症を制御できないか
日本大学, 若手研究者助成金, Jun. 2023 - Mar. 2024
山口 卓哉 - Elucidation of the molecular mechanism for rejecting human blood cells by Kupffer cells in immunodeficient mouse
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2020 - Mar. 2023
山口 卓哉 - .
Central Institute for Experimental Animals, ., Apr. 2020 - Mar. 2021
山口 卓哉
