OCHIAI(KURITA) Tomoko

School of Dentistry at Matsudo Department of DentistryProject Professor

Research Keyword

  • Dysbiosis
  • 動脈硬化
  • Inflammasome
  • 歯周病
  • apoptosis
  • gut immunity
  • Bacterial growth
  • Inflammatory cytokine
  • Immunosuppressive effect
  • Periodontitis-associated bacteria
  • Immunology
  • Functional Basic Dentistry

Field Of Study

  • Life sciences, Conservative dentistry and endodontics, Periodontal Odontology
  • Life sciences, Oral medicine, Morphological Basic Odontology
  • Life sciences, Immunology, Immunology
  • Life sciences, Oral medicine (pathology), Functional Basic Dentistry

Career

  • Apr. 2016 - Present
    日本大学松戸歯学部, 微生物免疫学, 教授
  • Sep. 1984 - Aug. 1986
    アラバマ大学Birmingham校研究員

Educational Background

  • 1979
    Tokyo University of Pharmacy and Life Science, Faculty of Pharmaceutical Science, 衛生薬学科

Member History

  • May 2016 - Present
    理事, 歯科基礎医学会
  • 2012 - Present
    評議員, 日本歯周病学会
  • 2008 - Present
    評議員, 歯科基礎医学会
  • 2006 - Present
    評議員, 日大口腔科学会

Award

  • 日本歯周病学会学術賞
    歯周病原嫌気性菌の産生する酪酸によるT細胞アポトーシス誘導機序の解明

Paper

  • 口腔内バイオフィルムの特徴と制御
    落合智子
    バイオインダストリー, Sep. 2022, Not refereed, Invited
    Lead
  • Sublingual immunization with recombinant GroEL plus CpG-ODN inhibits Porphyromonas gingivalis-induced inflammation and alveolar bone loss.
    Chang E; Kobayashi R; Hagiwara-Hamano M; Kurita-Ochiai T; Komiya M.
    Mol. Oral Microbiol., Apr. 2022, Refereed
    Last
  • Butyrate paradox -歯周病研究で解った酪酸の為害作用
    落合邦康、落合智子
    日本臨床腸内微生物学会誌, Dec. 2021, Not refereed, Invited
  • Actinomyces caprocornis sp. nov. isolated from the oral cavity of a Japanese serow.
    Saito M; Shinozaki-Kuwahara N; Hashizume-Takizawa T; Gotouda H; Senpuku H; Kurita-Ochiai T
    Microbiol. Immunol., Dec. 2021, Refereed
    Last
  • Lactic acid bacteria prevent both periodontitis and atherosclerosis exacerbated by periodontitis in spontaneously hyperlipidemic mice
    Ryoki Kobayashi; Tomomi Hashizume-Takizawa; Tomoko Kuritad-Ochiai
    Journal of Periodontal Research, Mar. 2021, Refereed, Not invited
    Corresponding
  • Probiotic potential of lactobacilli isolated from saliva of periodontally healthy individuals
    Hirasawa M; Kurita-Ochiai T
    Oral Health and Preventive Dentistry, Jun. 2020, Refereed, Not invited
    Corresponding
  • Oral bacteria affect gut microbiome and intestinal immunity
    Kobayashi R; Hashizume-Takizawa T; Ogawa Y; Kurita-Ochiai T
    Pathogen and Disease, Jun. 2020, Refereed, Not invited
    Corresponding
  • Nasal vaccination with GroEL plus CpG ODN inhibits P. gingivalis-induced inflammation and alveolar bone loss
    Chang E; Kobayashi R; Hagiwara M; Kurita-Ochiai T; Komiya M.
    Int J Oral-Med Science, Mar. 2020, Refereed, Not invited
    Corresponding
  • Involvement of Fusobacterium nucleatum in bone resorption and periodontal tissue inflammation.
    Ogawa Y; Kobayashi R; Kono T; Toda M; Okada H; Kurita-Ochiai T; Komiya M.
    Int J Oral-Med Science, Mar. 2020, Refereed, Not invited
    Corresponding
  • Effect of periodontopathic bacteria Fusobacterium nucleatum on intestinal immune cells
    Ogawa Y; Kobayashi R; Kono T; Toda M; Okada H; Kurita-Ochiai T; Komiya M.
    Int J Oral-Med Sci., Mar. 2020, Refereed, Not invited
    Corresponding
  • Evaluation of vending properties and adherence of Candia albicans to antibacterial-glass- added polyethertherketone as a denture base material.
    Yoshizaki S; Saito M; Shinozaki-Kuwahara N; Asano T; Kurita-Ochiai T; Komiyama O.
    Int J Oral-Med Science, Mar. 2020, Refereed, Not invited
  • 義歯床用材料を目的としたポリエーテルエーテルケトン材料の曲げ特性および真菌付着能の評価
    吉崎聡、斉藤真規、桑原(篠崎)紀子、浅野隆、落合(栗田)智子、小見山道
    日大口腔科学, Dec. 2019, Refereed, Not invited
  • Oral challenge with Streptococcus sangunis induces aortic inflammation and accelerates atherosclerosis in spontaneously hyperlipidemic mice.
    1. Hashizume-Takizawa T; Kobayashi R; Shinozaki-Kuwahara N; Saito M; Kurita-Ochiai T.
    Biochem. Biophys. Res. Commun., Oct. 2019, Refereed, Not invited
  • The Intraday and Day-to-Day Fluctuation of the Antimicrobial Properties in Saliva as an Indicator of Resistance to the Oral Mucosal Disease,
    M. Ono; T. Watanabe; S. Kimoto; R. Kobayashi; T. Kurita-Ochiai; Y. Kawai
    Int J Oral-Med Sci, Jun. 2019, Refereed, Not invited
  • Aggregatibacter actinomyctemcomitans-sensitized monocytes induce endothelial cell apoptosis
    3.Hirasawa M; Hashizume-Takizawa T; Kobayashi R; Saito M; Shinoaki-Kuwahara N; Kurita-Ochiai T.
    Int J Oral-Med Science, Jun. 2019, Refereed, Not invited
    Corresponding
  • Lactobacillus helveticus SBT2171 up-regulates the expression of β-defensin and ameliorates periodontal disease caused by Porphyromonas gingivalis
    Kobatake E; Kobayashi R; Kabuki T; Kurita-Ochiai T.
    Microbiol Immunol., Jun. 2019, Refereed, Not invited
  • Evaluation of suitable antigens and adjuvant concentration for sublingual immunization to prevent periodontal disease.
    Chang E; Kobayashi R; Hagiwara M; Komiya M; Kurita-Ochiai T.
    Oral Sci. Int., May 2019, Refereed, Not invited
  • CCR7-deficient mice exhibit a delayed antigen-specific mucosal IgA antibody response to an oral recombinant Salmonella strain
    Hashizume-Takizawa T; Kobayashi R; Tsuzukibashi O; Saito M; Kurita-Ochiai T.
    Pathog Dis., Apr. 2019, Refereed, Not invited
  • Nasal immnization with a vaccinia virus-based pentavalent H5N1 avian influenza vaccine induces cellular immunity in the respiratory tracrt of mice
    Tomomi Hashizume-Takizawa; Megumi Fuse; Noriko Shinozaki-Kuwahara; Masanori Saito; Ryoki Kobayashi; Tomoko Kurita-Ochiai
    Int. J. Oral-Med. Sci., Mar. 2019, Refereed, Not invited
  • Distinct roles for Peyer's patch B cells for induction of antigen-specific IgA antibody responses in mice given oral recombinant Salmonella.
    Tomomi Hashizume-Takizawa; Naoko Shibata; Yosuke Kurashima; Hiroshi Kiyono; Tomoko Kurita-Ochiai; Kohtaro Fujihashi
    International Immunology, Mar. 2019, Refereed, Not invited
  • 歯面漂白用加熱装置を用いて光変換蛍光タンパク質発現 マウスのリンパ組織由来細胞を光変換させるための至適時間の検討
    瀧澤智美、小林良喜、落合智子
    日大口腔科学, Mar. 2019, Refereed, Not invited
  • C/EBPβ and YY1 bind and interact with Smad3 to modulate lipopolysaccharide-induced amelotin gene transcription in mouse gingival epithelial cells.
    Nakayama Y; Kobayashi R; Iwai Y; Noda K; Yamazaki M; Kurita-Ochiai T; Yoshimura A; Ganss B; Ogata Y.
    FEBS Open Bio., Dec. 2018, Refereed, Not invited
  • Porphyromonas gingivalis induces apoptosis and autophagy via er stress in human umbilical vein endothelial cells
    Hirasawa M; Kurita-Ochiai T.
    Mediators Inflamm., Jul. 2018, Refereed, Not invited
  • Pseudopropionibacterium rubrum sp. Nov., a novel red-pigmented species isolated from human gingival sulcus
    2.Saito M; Shinozaki-Kuwahara N; Tsudukibashi O; Hashizume-Takizawa T; Kobayashi R; Kurita-Ochiai T.
    Miclobiol. Immunol., Jun. 2018, Refereed, Not invited
  • Glucosyltransferase-Bの経鼻免疫により誘導される抗原特異的抗体応答の検討
    瀧澤智美、布施恵、落合智子
    日大口腔科学, Jun. 2018, Refereed, Not invited
  • Comparison of Evaluating The Ratio of Cariogenic Bacteria in Plaque and Saliva Samples
    4.Gotouda H; Shinozaki-Kuwahara N; Taguchi C; Endo H; Ohta M; Shimosaka M; Tamamura R; Matsune K; Kono Y; Okada H; Kurita-Ochiai T; Ito T.
    Oral Health and Dental Management., Apr. 2018, Refereed, Not invited
  • Evaluation of the Proportion of Cariogenic Bacteria Associated with Dental Caries
    Hiroya Gotouda; Noriko Shinozaki-Kuwahara; Chieko Taguchi; Michiharu Shimosaka; Mitsuhiro Ohta; Takanori Ito; Tomoko Kurita-Ochiai; Ikuo Nasu
    Epidemiology, an open access journal, Oct. 2017, Refereed, Not invited
  • Evaluation of Dental Caries and Concomitant Infection Based on the Ratio of Cariogenic Bacteria using Plaque Samples in Adults
    Hiroya Gotouda; Noriko Shinozaki-Kuwahara; Chieko Taguchi; Mitsuhiro Ohta; Michiharu Shimosaka; Takanori Ito; Koichi Hiratsuka; Tomoko Kurita-Ochiai; Ikuo Nasu
    Dentistry, Oct. 2017, Refereed, Not invited
  • Localization and expression pattern of amelotin, odontogenic ameloblast-associated protein and follicular dendritic cell-secreted protein in the junctional epithelium of inflamed gingiva
    Yohei Nakayama; Ryoki Kobayashi; Sari Matsui; Hiroyoshi Matsumura; Yasunobu Iwai; Keisuke Noda; Mizuho Yamazaki; Tomoko Kurita-Ochiai; Atsutoshi Yoshimura; Tamayuki Shinomura; Bernhard Ganss; Yorimasa Ogata
    ODONTOLOGY, Jul. 2017, Refereed, Not invited
  • Attachment of mouse osteoblast-like cells onto fibronectin- or albumin-immobilized poly (lactic acid-e-caprolactone) films.
    Fuse M; Hayakawa T; Hashizume-Takizawa T; Suzuki H; Wakai H; Nakanishi M; Niki Y; Sung-Moon H; Asaka K; Kurita-Ochiai T.
    J. Oral Tissue Engin., Jun. 2017, Refereed, Not invited
  • Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
    R. Kobayashi; T. Kobayashi; F. Sakai; T. Hosoya; M. Yamamoto; T. Kurita-Ochiai
    SCIENTIFIC REPORTS, Apr. 2017, Not refereed, Not invited
  • 納豆食による自然免疫機構誘導の検討
    小林良喜、田口千重子、有川量崇、内山敏一、斎藤孝親、落合智子
    日大口腔科学, Mar. 2017, Refereed, Not invited
  • Isolation and identification methods of Rothia species in oral cavities
    Osamu Tsuzukibashi; Satoshi Uchibori; Taira Kobayashi; Koji Umezawa; Chiho Mashimo; Takayuki Nambu; Masanori Saito; Tomomi Hashizume-Takizawa; Tomoko Ochiai
    JOURNAL OF MICROBIOLOGICAL METHODS, Mar. 2017, Refereed, Not invited
  • Association between Dental Caries in Adults and Evaluation of Streptococcus Sobrinus in Plaque Samples.
    Gotouda H; Shinozaki-Kuwahara N; Taguchi C; Ohta M; Shimosaka M; Hiratsuka K; Ito T; Kurita-Ochiai T; Hanada N; Nasu I
    Oral Health and Dental Management, Jan. 2017, Refereed, Not invited
  • Porphyromonas gingivalis promotes low-density lipoprotein oxidation and atherosclerosis
    Kurita-Ochiai T; Hashizume-Takizawa T; Kobayashi R; Bhawal UK; Hosono A; Kinukawa N; Oguchi S.
    J. Oral Biosci., Jan. 2017, Refereed, Not invited
    Lead
  • 樹状細胞を活性化する経鼻DNAアジュバントの開発—感染症・NCD制御を目指す粘膜ワクチンー
    片岡宏介、土居貴士、神光一郎、上根昌子、伊藤博夫、落合(栗田)智子、三宅達郎
    口腔衛生学会雑誌, Jan. 2017, Refereed, Not invited
  • Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease
    Yohei Yamaguchi; Tomoko Kurita-Ochiai; Ryoki Kobayashi; Toshihiko Suzuki; Tomohiro Ando
    INFLAMMATION RESEARCH, Jan. 2017, Refereed, Not invited
  • Combined effects of starvation and butyrate on autophagy-dependent gingival epithelial cell death.
    Evans M; Morofushi T; Tsuda H; Mikami Y; Zhano N; Ochiai K; Kurita-Ochiai T; Yamamoto M; Otsuka K; Suzuki N.
    J. Periodontal Res., Sep. 2016, Refereed, Not invited
  • Transformation of Aggregatibacter actinomycetemcomitans with green fluorescent protein.
    Tomomi Hashizume-Takizawa; Noriko Shinozaki-Kuwahara; and Tomoko Kurita-Ochiai
    Int. J. Oral-Med. Sci., Feb. 2016, Refereed, Not invited
  • 歯周病原性黒色集落嫌気性桿菌群のための増殖培地の検討
    斎藤真規、桒原紀子、續橋治、小林良喜、平澤正晃、落合智子
    日大口腔科学, Dec. 2015, Refereed, Not invited
  • Periodontal disease-induced atherosclerosis and oxidative stress
    Kurita-Ochiai T; Ru Jia; Yu Cai; Yamaguchi Y; Yamamoto M.
    Antioxidants, Sep. 2015, Refereed, Invited
    Lead
  • MC3T3-E1 cell assay on collagen or fibronectin immobilized poly (lactic acid-e-caprolactone) film.
    Fuse M; Hayakawa T; Hashizume-Takizawa T; Takeuchi R; Kurita-Ochiai T; Fujita-Yoshigaki J; Fukumoto M.
    J. Hard Tissue Biol., Jul. 2015, Refereed, Not invited
  • 口腔内短鎖脂肪酸の歯周組織と全身疾患に及ぼす影響
    落合邦康、今井健一、落合智子
    腸内細菌学雑誌, Aug. 2014, Not refereed, Invited
  • Periodontal pathogens and atherosclerosis: Implications of inflammation and oxidative modification of LDL.
    Kurita-Ochiai T.; and Yamamoto M.
    BioMed Res. Int., Jun. 2014, Refereed, Not invited
    Lead
  • Midazolam inhibits IgE production in mice via suppression of class switch recombination.
    Kusama H; Kobayashi R and Kurita-Ochiai T.
    J. Oral Sci., Jun. 2014, Refereed, Not invited
    Corresponding
  • Alternative effects of a metabolic by-product, butyric acid, produced by oral anaerobes
    Ochiai K. and Kurita-Ochiai T.
    Nihon Yakurigaku Zasshi, Jun. 2014, Not refereed, Invited
  • Sublingual vaccine with GroEL attenuates atherosclerosis.
    Hagiwara M; Kurita-Ochiai T; Kobayashi R; Hashizume-Takizawa T; Yamazaki K; and Yamamoto M.
    J. Dent. Res., Apr. 2014, Refereed, Not invited
    Corresponding
  • Comparison of Apolipoprotein E knockout mice and spontaneously hyperlipidemic mice in Porphyromonas gingivalis-induced atherosclerosis.
    Tomita N; Hahizume-Takizawa T; and Kurita-Ochiai T.
    Int. J. Oral-Med. Sci., Mar. 2014, Refereed, Not invited
    Corresponding
  • Enhancement of antimicrobial peptide induction in both oral and intestinal mucosa by fermented daily products.
    Arikawa K; Kobayashi R; Kurisu R; Taguchi C; Uchiyama T; Kamachi K; Kurita-Ochiai T; and Nasu I.
    Int. J. Oral-Med. Sci., Mar. 2014, Refereed, Not invited
  • Establishment of a convenient sandwich-ELISA for direct quantification of glucosyltransferase-I: application for dual diagnosis of dental caries.
    Hashizume-Takizawa T; Shinozaki-Kuwahara N; Tomita N; and Kurita-Ochiai T.
    Monoclon. Antib. Immunodiagn. Immunother., Jan. 2014, Refereed, Not invited
  • Porphyromonas gingivalis infection enhances Th17 responses for development of atherosclerosis
    Yu Cai; Ryoki Kobayashi; Tomomi Hashizume-Takizawa; Tomoko Kurita-Ochiai
    Archives of Oral Biology, 2014, Refereed, Not invited
  • Midazolam inhibits IgE production through suppression of class switch recombination.
    Kusama H; Kobayashi R; Kurita-Ochiai T; Hashizume-Takizawa T; Ishikawa M; Fujita Y; and Shibutani K.
    Int. J. Oral-Med. Sci., Dec. 2013, Refereed, Not invited
    Corresponding
  • Comparison of mucosal immune response after oral, nasal or sublingual immunization with an outer membrane protein of Porphyromonas gingivalis.
    Ikeda T; Kobayashi R; and Kurita-Ochiai T.
    Int. J. Oral-Med. Sci., Dec. 2013, Refereed, Not invited
    Corresponding
  • Traditional Japanese fermented food; Natto enhances NK cell activity in intestine.
    R. Kobayashi; K. Arikawa; K. ichikawa; C. Taguchi; T. Utsunomiya; M. Iijima; T. Uchiyama; K. Kamachi; I. Nasu; M. Fukumoto; Y. Kawai and T. Ochiai
    Int. J. Oral-Med. Sci., Sep. 2013, Refereed, Not invited
  • Characterization of inflammation-derived CD11c+ dendritic cells in mouse model of periodontal disease.
    Kobayashi R; Kurita-Ochiai T; Hashizume-Takizawa T; Fujihashi K; and Yamamoto M.
    Int. J. Oral-Med. Sci., Sep. 2013, Refereed, Not invited
  • Nasal immunization with the 40-kDa outer membrane protein of Porphyromonas gingivalis plus cholera toxin induces protective immunity in aged mice
    Yu Cai; Tomoko Kurita-Ochiai; Ryoki Kobayashi; Tomomi Hashizume; Masafumi Yamamoto
    JOURNAL OF ORAL SCIENCE, Jun. 2013, Refereed, Not invited
  • Butyric acid retention in gingivali tissue induces oxidative stress in jugular blood mitochondria.
    Cueno ME; Imai K; Matsukawa N; Tsukahara T; Kurita-Ochiai T; Ochiai T.
    Cell stress and Chaperones, Jun. 2013, Refereed, Not invited
  • Periodontal pathogen accelerates lipid peroxidation and atherosclerosis.
    Jia R; Kurita-Ochiai T; Oguchi S; and Yamamoto M.
    J. Dent. Res., Mar. 2013, Refereed, Not invited
    Corresponding
  • Serum antibodies against Porphyromonas gingivalis GroEL are insufficient to induce P. gingivalis-accelerated atherosclerosis.
    Hagiwara M; Kurita-Ochiai T; Hashizume-Takizawa T; Suemitsu M; Kuyama K; Yamamoto H; Yamazaki K; Akimoto Y; and Yamamoto M.
    Int. J. Oral-Med. Sci., Mar. 2013, Refereed, Not invited
    Corresponding
  • Functional imbalance between Th17, Th1, and Treg cells in Aggregatibacter actinomycetemcomitans-accelerated atherosclerosis.
    Jia R; Kurita-Ochiai T; Hashizume-Takizawa T; Kobayashi R; and Yamamoto M.
    Int. J. Oral-Med. Sci., Mar. 2013, Refereed, Invited
    Corresponding
  • Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.
    Cai Y; Kurita-Ochiai T; Hashizume T; and Yamamoto M.
    FEMS Pathogen and Disease, Jan. 2013, Refereed, Not invited
    Corresponding
  • Correlation between the amount ofr glucosyltransferase-B and the decayed, missing and filled teeth index in oral samples.
    Hashizume T; Shinozaki-Kuwahara N; Kurita-Ochiai T; and Yamamoto M.
    Int. J. Oral-Med. Sci., Mar. 2012, Refereed, Not invited
  • Nasal vaccination with a fusion protein of hemagglutinin a antigenic region and maltose-binding protein elicits CD4+ T cell responses via toll-like receptor 4.
    Du Y; Hashizume T; Kurita-Ochiai T; Abiko Y; Ikeda T; Tsurumi A; Tomita N; and Yamamoto M.
    Int. J. Oral-Med. Sci., Mar. 2012, Refereed, Not invited
    Corresponding
  • Glucosyltransferase-I is capable of functioning as an adjuvant to promote immune responses against the co-administered protein glucosyltransferase-B.
    Yuzawa S; Hashizume T; Kobayashi R; Kurita-Ochiai T; and Yamamoto M.
    Int. J. Oral-Med. Sci., Mar. 2012, Refereed, Not invited
    Corresponding
  • Intranasal immunization with Porphyromonas gingivalis outer membrane protein inhibits P. gingivalis-induced atherosclerosis in C57BL/6 mice fed a high-fat diet.
    Fukasawa A; Kurita-Ochiai T; Hashizume T; Kobayashi R; Akimoto Y; and Yamamoto M.
    Int. J. Oral-Med. Sci., Mar. 2012, Refereed, Not invited
    Corresponding
  • Sublingual vaccination with fusion protein consisting of the functional domain of hemagglutinin A of Porphyromonas gingivalis and Eschericha coli malyose-binding protein elicits protective immunity in the oral cavity.
    Yuzawa S; Kurita-Ochiai T; Hashizume T; Kobayashi R; Abiko Y; and Yamamoto M.
    FEMS Immunol. Med. Microbio., Mar. 2012, Refereed, Not invited
    Corresponding
  • Porphyromonas gingivalis accelerates atherosclerosis in C57BL/6 mice fed a high-fat diet.
    Fukasawa A; Kurita-Ochiai T; Hashizume T; Kobayashi R; Akimoto Y; and Yamamoto M.
    Immunopharmacol. Immunotoxicol., Mar. 2012, Refereed, Not invited
    Corresponding
  • T helper cytokine responses induced by nasal imminization with glucosyltransferase-I of streptococcus sobrinus.
    Int. J. Oral-Med. Sci., Mar. 2011, Refereed, Not invited
  • A fusion protein of the hemagglutinin A antigenic region of Porphyromonas gingivalis and maltose-binding protein induces antibody responses in the oral cavity.
    Int. J. Oral-Med. Sci., Mar. 2011, Refereed, Not invited
  • Butyric acid effects in the development of periodontitis and systemic diseases.
    Kuniyasu Ochiai; Kenichi Imai; Muneaki Tamura; Tomoko Kurita-Ochiai
    J. Oral. Biosci., Mar. 2011, Refereed, Not invited
  • Nasal immunization with a fusion protein consisting of the hemagulutinin a antigenic region and the maltose-binding protein elicits CD11c+ CD8+ dendritic cells for induced long-term protective immunity
    Yuan Du; Tomomi Hashizume; Tomoko Kurita-Ochiai; Satoshi Yuzawa; Yoshimitsu Abiko; Masafumi Yamamoto
    Infection and Immunity, Feb. 2011, Refereed, Not invited
  • Porphyromonas gingivalis stimulates monocyte adhesion to human umbilical vein endothelial cells.
    FEMS Immunol. Med. Microbiol., Jan. 2011, Refereed, Not invited
  • Nasal administration of glucosyltransferase-I of streptococcus sobrinus without adjuvant induces protective immunity.
    Keita Watanabe; Tomomi Hashizume; Tomoko Kurita-Ochiai; Yoshiaki Akimoto; Masafumi Yamamoto
    Journal of Vaccines & Vaccination, Dec. 2010, Refereed, Not invited
  • Butyric acid induces apoptosis via oxidative stress in Jurkat T cells
    T. Kurita-Ochiai; K. Ochiai
    Journal of Dental Research, Jul. 2010, Refereed, Not invited
    Lead
  • Aggregatibacter actinomycetemcomitans accelerates atherosclerosis with an increase in atherogenic factors in spontaneously hyperlipidemic mice.
    Tao Zhang; Tomoko Kurita-Ochiai; Tomomi Hashizume; Yuan Du; Sumito Oguchi; Masafumi Yamamoto
    FEMS Immunol. Med. Microbiol., May 2010, Refereed, Not invited
    Corresponding
  • Oral immunization with Porphyromonas gingivalis outer membrane protein and CpGoligonucleotides elicits T helper 1 and 2 cyotokines for enhanced protective immunity.
    Mol. Oral Microbiol., Mar. 2010, Refereed, Not invited
  • Mucosal immunity in CD4-deficient mice. Direct evidence for mucosal IgA antibody responses.
    Int. J. Oral-Med. Sci., Feb. 2010, Refereed, Not invited
  • Effet of Porphyromonas gingivalis on human umbilical vein endothelial cells.
    Int. J. Oral-Med. Sci., Feb. 2010, Refereed, Not invited
  • Aggregatibactor actinomycetemcomitans leads to endothelial apoptosis and atherosclerosis development in spontaneously hyperlipidemic mice.
    Int. J. Oral-Med. Sci., Jan. 2010, Refereed, Not invited
    Corresponding
  • T helper cytokine responses elicited by nasal immunization with heat-killed recombinant lactobacillus casei expressing outer membrane protein of Porphyromonas gingivalis.
    Int. J. Oral-Med. Sci., Jan. 2010, Refereed, Not invited
  • Immunogenicity and protective efficacy of heat-killed recombinant lactobacillus casei expressing outer membrane protein of Porphyromonas gingivalis.
    Int. J. Oral-Med. Sci., Dec. 2009, Refereed, Not invited
  • Oral immunization with outer membrane protein of Porphyromonas gingivalis and CpG oligodeoxynucleotides elicits both T helper 1 and 2 cytokines for enhanced protective immunity.
    C. Liu; T. Hashizume; T. Kurita-Ochiai; K. Fujihashi; M. Yamamoto
    Mol. Oral Microbiol., Nov. 2009, Refereed, Not invited
  • Subgingival vaccination with outer membrane protein of Porphyromonas gingivalis and Flt3 ligand elicits protective immunity in the oral cavity.
    Biochem. Bîophys, Res. Commun., Oct. 2009, Refereed, Not invited
  • Intranasal immunization with Porphyromonas gingivalis and atherosclerosis
    Yukiko Koizumi; Tomoko Kurita-Ochiai; Sumito Oguchi; Masafumi Yamamoto
    Immunopham. Immunotoxicol., Sep. 2009, Refereed, Not invited
    Corresponding
  • Effects of butyric acid on the periodontal tissue.
    Japanese Dental Science Review, May 2009, Refereed, Not invited
  • Nasal vaccination with an outer membrane protein of porphyromonas gingivalis and nontoxic chimeric enterotoxin adjuvant induces both t helper 1 and t helper 2 responses.
    Int. j. Oral-Med. Sci., Feb. 2009, Refereed, Not invited
  • Transcutaneous immunization induces a higher antibody immune response than parental immunization.
    Int. J. Oral-Med. Sci., Feb. 2009, Refereed, Not invited
  • Transcutaneous immunization with the outer membrane protein of P. gingivalis elicits long-term protective immunity in the oral cavity.
    Kazuaki Ishikura; Tomomi Hashizume; Tomoko Kurita-Ochiai; Masaharu Makimura; Masafumi Yamamoto
    J. oral Biosci., Jan. 2009, Refereed, Not invited
  • 臨床分離歯肉繊維芽細胞の短鎖脂肪酸感受性およびアポトーシス誘導性の比較による歯周病発症機序の検討
    Journal of Germfree Life and Gnotobiology, Sep. 2008, Refereed, Not invited
  • 歯周病原嫌気性菌の産生する酪酸によるT細胞アポトーシス誘導機序の解明
    落合 智子
    日本歯周病学会会誌, Apr. 2008, Not refereed, Not invited
    Lead
  • Nasal immunization with P. gingivalis-induced atherosclerosis and inflammation in spontaneously hyperlipidemic mice.
    Koizumi Y.; Kurita-Ochiai T.; Oguchi S.; Yamamoto M
    Infection and Immunity, Apr. 2008, Refereed, Not invited
    Corresponding
  • Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies.
    Momoi F.; Hashizume T.; Kurita-Ochiai T.; Yuki Y.; Kiyono H.; Yamamoto M
    Infection and Immunity, Apr. 2008, Refereed, Not invited
  • Increased susceptibility to tumor necrosis factor-alpha in butyric acid-induced apoptosis is caused by downregulation of cFLIP expression in Jurkat T cells.
    kurita-ochiai t; ochiai k.
    Microbiol. Immunol., Apr. 2008, Refereed, Not invited
  • Nasal immunization with a 40-kDa outer membrane protein of Porphyromonas gingivalis inhibits atherosclerotic plaque accumulation caused by oral P. gingivalis infection.
    KOIZUMI Y.; KURITA-OCHIAI T.; OGUCHI S.; YAMAMOTO M.
    International Journal of Oral Medical Science, Mar. 2008, Refereed, Not invited
  • Transcutaneous immunization with an outer membrane protein of Porphyromonas gingivalis without adjuvant elicits marked antibody responses
    Y. Koizumi; T. Kurita-Ochiai; M. Yamamoto
    Oral Microbiology Immunology, Jan. 2008, Refereed, Not invited
    Corresponding
  • Butyric acid induces apoptosis in inflamed fibroblasts.
    Kurita-Ochiai T.; Seto S.; Suzuki N.; Yamamoto M.; Otsuka K.; Ochiai K
    Journal of Dental Research, Jan. 2008, Refereed, Not invited
    Lead
  • Isolated lymphoid follicles are not IgA inductive sites for recombinant Salmonella
    T. Hashizume; F. Momoi; T. Kurita-Ochiai; S. Kaminogawa; A. Hosono; K. Kataoka; N. Shinozaki-Kuwahara; M. kweon; M. Yamamoto
    Biochemical and Biophysical Research Communication, Aug. 2007, Refereed, Not invited
  • 酪酸誘導T細胞アポトーシス解除機構における短鎖脂肪酸のCD44発現に及ぼす影響
    落合 邦康、藤岡 隼、阿部 和正、落合 智子
    消化器と免疫, May 2007, Refereed, Not invited
  • CpG oligodeoxynucleotide is an effective adjuvant for transcutaneous immunization.
    Liu C.; Hashizume T.; Kurita-Ochiai T.; Yamamoto M
    International Journal of Oral Medical Science, Mar. 2007, Refereed, Not invited
  • Characterization of the effects of butyric acid on cell proliferation, cell cycle distribution and apoptosis
    Tomoko Kurita-Ochiai; Tomomi Hashizume; Hideo Yonezawa; Kuniyasu Ochiai; and Masafumi Yamamoto
    FEMS Immunology and Medical Microbiology, Jun. 2006, Refereed, Not invited
    Lead
  • 酪酸誘導T細胞アポトーシス回避機構における接着分子発現制御の解析
    落合 邦康、栗田(落合)智子
    Journal of Germfree Life and Gnotobiology, Mar. 2006, Not refereed, Not invited
  • Apoptosis induced by short-chain fatty acids modulates immmunoresponses: Role of cell-to-cell communication in inhibiting butyric acid-induced T cell apoptosis.
    Ochiai K.; Kurita-Ochiai T.
    Bioscience Microflora, Oct. 2005, Refereed, Not invited
  • Role of cell-to-cell communication in inhibiting butyric acid-induced T-cell apoptosis
    Kurita-Ochiai T.; Seto S.; Ochiai K.
    Infection and Immunity, Oct. 2004, Refereed, Not invited
    Lead
  • Cellular mechanisms involved in butyric-acid-induced T cell apoptosis.
    Ochiai K. and Kurita-Ochiai T
    Immunology2004, Sep. 2004, Refereed, Not invited
  • Cell to cell communication in inhibiting butyric acid-induced T-cell response
    Kurita-Ochiai T.; Ochiai K.; Fukushima K.
    Immunology 2004, Sep. 2004, Refereed, Not invited
    Lead
  • Periocontopathic bacteria-infection and apoptosis (II) Role of human gingival fibroblasts on the rescue of butyric acid-induced T cell-apoptosis.
    落合邦康、栗田智子
    Hospital Dentistry & Oral-Maxillofacial Surgery, Dec. 2003, Refereed, Not invited
  • Mycobacterium bovis Bacillus Calmette-Guerin infection promote SOCS induction and inhibits IFN-j-stimulates JAK/STAT signaling in J774 macrophages.
    Imai K; kurita-Ochiai T and Ochai K
    FEMS Immunol. and Med. Microbiol., Nov. 2003, Refereed, Not invited
  • 代謝嫌気性産物 ・ 脂肪酸の為害作用:T細胞アポトーシス誘導機構の解析
    消化器と免疫, Aug. 2003, Not refereed, Not invited
  • 代謝嫌気性産物・脂肪酸の為害作用:線維芽細胞のアポトーシス誘導性
    消化器と免疫, Aug. 2003, Not refereed, Not invited
  • Cellular events involved in butyric acid-induced T cell apoptosis
    T Kurita-Ochiai; S Amano; K Fukushima; K Ochiai
    J. Immunol., Jul. 2003, Refereed, Not invited
    Lead
  • Volatile fatty acids-induced apoptosis modulates immunoresponse in gingival tissue
    Ochiai K and Kurita-Ochiai T
    Dentistry in Japan, Mar. 2003, Refereed, Not invited
  • Periodontopathic bacteria and systemic infection, Part 1 : Effect of apoptosis induced by metabolic by-products of anaerobic bacteria in gingival immunoresponse.
    Ochiai K and Kurita-Ochiai T
    Hospital Dentistry & Oral-Maxillofacial Surgery, Dec. 2002, Refereed, Not invited
  • Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway
    Ogawa T; Asai Y; Hashimoto M; Takeuchi O; Kurita-Ochiai T
    International Immunology, Nov. 2002, Refereed, Not invited
  • Periodotopathic bacteria-infection and apoptosis. Part 2: Role of human gingival fibroblasts on the rescue of butyric acid-induced T-cell apoptosis.
    Ochiai; K.; and Kurita-Ochiai; T.
    Hosp. Dent. & Oral-Maxillofacial Surgery, Sep. 2002, Refereed, Not invited
  • Human gingival fibroblasts rescue butyric acd-induced T cell apoptosis
    Kurita-Ochiai T; Ochai K; Suzuki N; Otsuka K; Fukushima K.
    Infection and Immunity, May 2002, Refereed, Not invited
    Lead
  • Butyric acid-induced T-cell apoptosis is mediated by caspase-8 and-9 activation in a Fas-independent manner
    Kurita-Ochiai T; Ochiai K and Fukushima K.
    Clinical and diagnostic laboratory immunology, Mar. 2001, Refereed, Not invited
    Lead
  • 歯周病原性細菌とアポトーシス
    化学療法の領域, Jan. 2001, Not refereed, Not invited
  • Butyric-acid-induced apoptosis in murine thymocytes and splenic T-and B-cells occurs in the absence of p53.
    Kurita-Ochiai T; Ochiai K and Fukushima K.
    Journal of Dental Research, Dec. 2000, Refereed, Not invited
    Lead
  • Role of T cell subset on the immunosuppression induced by Actinobacillus actinomycetemcomitans.
    K. Ochiai; T. Kurita-Ochiai
    Journal of Oral Science, Mar. 1999, Refereed, Not invited
  • Co-aggregation as a virulent factor of Streptococcus sanguis isolated from infective endocarditis
    Journal of Oral Science, Mar. 1999, Refereed, Not invited
  • Lipopolysaccharide stimulates butyric acid-induced apoptosis in human peripheral blood mononuclear cells
    T Kurita-Ochiai; K Fukushima; K Ochiai
    Infection and Immunity, Jan. 1999, Refereed, Not invited
    Lead
  • Purification of immunosuppressive factor from Capnocytophaga ochracea
    K Ochiai; H Senpuku; T Kurita-Ochiai
    Journal of Medical Microbiology, Dec. 1998, Refereed, Not invited
  • Volatile fatty acid, metabolic by-product of periodontopathic bacteria, induces apotosis in WEHI 231 and RAJI B lymphoma cells and splenic B cells
    T Kurita-Ochiai; K Ochiai; K Fukushima
    Infection and Immunity, Jun. 1998, Refereed, Not invited
    Lead
  • Butyric acid-induced apoptosis of murine thymocytes, splenic T cells, and human Jurkat T cells
    T KuritaOchiai; K Fukushima; K Ochiai
    Infection and Immunity, Jan. 1997, Refereed, Not invited
    Lead
  • Immunosuppressive factor from Actinobacillus actinomycetemcomitans down regulates cytokine production
    T KuritaOchiai; K Ochiai
    Infection and Immunity, Jan. 1996, Not refereed, Not invited
    Lead
  • Volatile fatty acids,metabolic by-products of periodontopathic bacteria,inhibit lymphocyte proliferation and cytokine production
    T KURITAOCHIAI; K FUKUSHIMA; K OCHIAI
    Journal of Dental Research, Jul. 1995, Not refereed, Not invited
    Lead
  • Effect of co-aggregation on the pathogenicity of oral bacteria
    K OCHIAI; T KURITAOCHIAI; Y KAMINO; T IKEDA
    Journal of Medical Microbiology, Sep. 1993, Not refereed, Not invited
  • Isolation and characterization of the substance isolated from streptosporangium species which inhibits lactic acid production by oral bacteria
    T IKEDA; T KURITAOCHIAI; T TAKIZAWA; M HIRASAWA
    General Pharmacology, Jul. 1993, Not refereed, Not invited
    Lead
  • 口腔細菌の病原因子:Coaggregationの病原性への影響
    日大口腔科学, Dec. 1992, Not refereed, Not invited
  • A.actinomycetemcomitansの非特異的免疫抑制作用
    落合邦康
    日大口腔科学, Oct. 1991, Not refereed, Not invited
  • Effect of periodontopathic bacteria on secondary immunoresponse and isotype switching
    K OCHIAI; T KURITA; T IKEDA
    Frontiers of mucosal immunology (Elsevier Pub), Jul. 1991, Not refereed, Not invited
  • Capnocytophagaによる免疫抑制作用
    日本歯周病学会会誌, Jun. 1991, Not refereed, Not invited
  • T cell networks for regulation of the mucosal immune system.
    Kiyono; H.; Kitamura; K.; Kurita; T.; and McGhee; J.R.
    Anali. Sclavo., Oct. 1988, Refereed, Not invited
  • Biological and Biochemical Characterization of Novel Lipid-like Antibacterial Substances (Mutalipocins) Produced by streptococcus mutans Strain 32K
    T KURITA; M HIRASAWA
    Journal of General Microbiology, Apr. 1988, Not refereed, Not invited
    Lead
  • Isotype-specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance.
    5. Kitamura; K.; Kiyono; H.; Suzuki; I.; Kurita; T.; Green; D.R.; and McGhee; J.R.
    Adv. Exp. Med. Biol., Apr. 1987, Refereed, Not invited
  • Isotype-specific immunoregulation: role of Fc alpha R+T cells and IBF alpha in IgA responses.
    6. Kurita; T.; Kiyono; H.; McGhee; M.L.; and McGhee; J.R.
    Adv. Exp. Med. Biol., Apr. 1987, Refereed, Not invited
  • Regulatory T cell networks in the secretory immune system.
    Eldridge; J.H.; Kiyono; H.; Suzuki; I.; Kurita; T.; Michalek; S.M.; and McGhee; J.R.
    Adv. Exp. Med. Biol., Apr. 1987, Refereed, Not invited
  • Isotype-specific immunoregulation; Characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor.
    Kurita; T.; Kiyono; H.; Komiyama; K.; Grossi; C.E.; and McGhee; J.R.
    J. Immunol., Jun. 1986, Refereed, Invited
    Lead
  • Isotype-specific immunoregulation : Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine peyer's patches
    Journal of Experimental Medicine, 1986, Not refereed, Not invited
  • Molecular Microbiology and Immunology of ┣DBStrepto(/)-┫DB-┣DBcoccus(/)-┫DB ┣DBmutans(/)-┫DB : Regulation of IgA responses to type1 and type2 Streptococcus mutans antigens
    Elsevier Science Publishers, 1986, Not refereed, Not invited
  • The boderland between caries and periodontal disease III : Induction and T cell regulation of IgA responses to ┣DBStreptococcus(/)-┫DB ┣DBmutans(/)-┫DB antigens
    Editions Medicine et Hygiene, 1986, Not refereed, Not invited
  • Anti-dental caries effect in rats and man of a bacteriocin purified from the oral bacterium Sreptococcus mutans C3603.
    1. Ikeda; T.; Koulourides; T.; Kurita; T.; Housch; T.; and Hirasawa; M.
    Archs. Oral Biol., Apr. 1985, Refereed, Not invited

MISC

  • Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss
    Chang E; Kobayashi R; Fujihashi K; Komiya M; Kurita-Ochiai T.
    Inflammation Res., 09 Nov. 2020, Refereed, Not invited
    Corresponding
  • 口腔内細菌の全身疾患への関わり
    落合邦康、マーニE.クエノ、落合智子
    化学療法の領域, 25 Feb. 2018, Not refereed, Not invited
  • 口腔内フローラと腸内フローラ
    落合邦康、落合智子
    PROGRESS IN MEDICINE, 10 Jun. 2017, Not refereed, Not invited
  • Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression
    Keisuke Seki; Marni E. Cueno; Noriaki Kamio; Yuko Saito; Atsushi Kamimoto; Tomoko Kurita-Ochiai; Kuniyasu Ochiai
    APOPTOSIS, Jun. 2016, Refereed, Not invited
  • Porphyromonas gingivalis口腔感染により発現するExosomeの検討。
    日大口腔科学, 01 Mar. 2016, Refereed, Not invited
  • Circadian rhythm affect S-IgA dynamic of the mucosal secretion
    R. Kobayashi; C. Taguchi; S. Yonenaga; K. Arikawa; T. Uchiyama; T. Kohno; I. Nasu; and T. Ochiai.
    Int. J. Oral-Med. Sci., 16 Sep. 2015, Refereed, Not invited
  • High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells
    Marni E. Cueno; Noriaki Kamio; Keisuke Seki; Tomoko Kurita-Ochiai; Kuniyasu Ochiai
    CELL STRESS & CHAPERONES, Jul. 2015, Not refereed, Not invited
  • Orally ingested Lactobacillus crispatus KT-11 inhibits Porphyromonas gingivalis-infected alveolar bone resorption
    Taguchi C.; Arikawa K.; Saito M.; Uchiyama T.; Watanabe I.; Tobita K.; Kobayashi R.; Ochiai T.; and Nasu I.
    Int. J. Oral-Med. Sci., 09 Jun. 2015, Refereed, Not invited
  • Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis
    Yohei Yamaguchi; Tomoko Kurita-Ochiai; Ryoki Kobayashi; Toshihiko Suzuki; Tomohiro Ando
    PATHOGENS AND DISEASE, Jun. 2015, Not refereed, Not invited
  • Aggregatibacter actinomycetemcomitans induces Th17 cells in atherosclerotic lesions
    Ru Jia; Tomomi Hashizume-Takizawa; Yuan Du; Masafumi Yamamoto; Tomoko Kurita-Ochiai
    PATHOGENS AND DISEASE, Apr. 2015, Not refereed, Not invited
  • T helper cytokine responses elicited by nasal immunization with heat-killed recombinant lactobacillus casei expressing outer membrane protein of Porphyromonas gingivalis.
    Tanaka Hiroyuki; Hashizume Tomomi; Abiko Yoshimitsu; Sewaki Tomomitsu; Nozaki Chikateru; Kurita-Ochiai Tomoko; Makimura Masaharu; Yamamoto Masafumi
    Int. J. Oral-Med. Sci., 20 Jan. 2010, Refereed, Not invited
  • Immunogenicity and protective efficacy of heat-killed recombinant lactobacillus casei expressing outer membrane protein of Porphyromonas gingivalis.
    Tanaka Hiroyuki; Hashizume Tomomi; Abiko Yoshimitsu; Sewaki Tomomitsu; Nozaki Chikateru; Kurita-Ochiai Tomoko; Makimura Masaharu; Yamamoto Masafumi
    Int. J. Oral-Med. Sci., 05 Dec. 2009, Refereed, Not invited
  • 歯周病における短鎖脂肪酸の為害作用−短鎖脂肪酸研究の歯学的意味論ー
    日大歯学, 30 Dec. 2007, Refereed, Not invited
  • Immunosuppressive effect of Prevotella intermedia
    日大口腔科学, 01 Dec. 1995, Refereed, Not invited
  • ADOPTIVE TRANSFER OF SUPPRESSOR T-CELLS INDUCED BY ACTINOBACILLUS-ACTINOMYCETEMCOMITANS REGULATES IMMUNE-RESPONSE
    T KURITAOCHIAI; K OCHIAI; N SAITO; T IKEDA
    JOURNAL OF PERIODONTAL RESEARCH, Jan. 1994, Refereed, Invited
  • Immunosuppressive effect induced by Actinobacillus actinomycetemcomitans: effect on globulin production and lymphokine synthesis
    Kurita-Ochiai; T.; Ochiai; K.; and Ikeda; T.
    Oral Microbiol. Immunol., 01 Dec. 1992, Refereed, Invited
    Lead
  • LOW-CARIOGENICITY OF THE TETRASACCHARIDE NYSTOSE
    T IKEDA; T KURITA; H HIDAKA; SM MICHALEK; M HIRASAWA
    GENERAL PHARMACOLOGY, 1990, Refereed, Invited
  • IMMUNOADJUVANT EFFECTS OF PERIODONTITIS-ASSOCIATED BACTERIA
    K OCHIAI; T KURITA; K NISHIMURA; T IKEDA
    JOURNAL OF PERIODONTAL RESEARCH, Sep. 1989, Refereed, Invited
  • Supression of Streptococcus mutans 6715 (g) in plaques by Streptococcus mutans 32K (c).
    Ikeda; T.; Kurita; T.; and Hirasawa; M.
    J. Oral Pathol., 01 Nov. 1988, Not refereed, Not invited
  • Biological and Biochemical Characterization of Novel Lipid-like Antibacterial Substances (Mutalipocins) Produced by streptococcus mutans Strain 32K
    T KURITA; M HIRASAWA
    Journal of General Microbiology, 01 Apr. 1988, Not refereed, Invited
    Lead
  • Isotype-specific immunoregulation; Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine peyer’s patches.
    Suzuki; I.; Kitamura; K.; Kiyono; H.; Kurita; T.; Green; D.R. and McGhee; J.R.
    J. Exp. Med., 01 Aug. 1986, Refereed, Invited
    Lead
  • Isotype-specific immunoregulation; Characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor.
    Kurita, T; Kiyono, H; Komiyama, K; Grossi, C.E; McGhee, J.R
    J. Immunol., 1986, Refereed, Invited
  • AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA) FOR DETECTION OF FC-ALPHA RECEPTORS ON ISOTYPE-SPECIFIC T-CELLS
    T KURITA; H KIYONO; SM MICHALEK; MCGHEE, JR
    JOURNAL OF IMMUNOLOGICAL METHODS, 1985, Refereed, Invited
  • Coupling sugar調整品Hのラットに対するう蝕原性
    日大口腔科学, 01 Mar. 1981, Refereed, Not invited
  • 各種StreptococcusによるCoupling sugar 8種調整品からの酸産生
    日大口腔科学, 01 Dec. 1979, Refereed, Invited

Books and other publications

  • 口腔内バイオフィルムの特徴と制御
    Joint work, 42-48, 落合 智子、落合 邦康
    バイオインダストリー, Sep. 2022
  • 口腔微生物学ー感染と免疫ー第7版
    Joint work
    学建書院, Mar. 2021
  • ヒト常在菌叢と生理機能・全身疾患
    落合智子, Joint work, 口腔感染症と動脈硬化, 落合智子
    シーエムシー出版, Aug. 2020
  • Mucosal Vaccines for Oral Disease
    Kurita-Ochiai T; Hashizume-Takizawa T; Kobayashi R; Yamamoto M, Joint work, Kurita-Ochiai T; Hashizume-Takizawa T; Kobayashi R; Yamamoto M.
    Academic Press, Oct. 2019
  • Oral microflora and systemic diseases
    Kurita-Ochiai T; Hashizume-Takizawa T; Kobayashi R; Yamamoto M, Joint work
    Academic Press, Oct. 2019
  • 口腔微生物学ー感染と免疫ー、第6版
    石原和幸; 落合智子他, Joint work, 石原和幸、落合智子他
    学建書院, Mar. 2018
  • 口腔内細菌の全身疾患への関わり
    落合邦康; マーニE. クエノ; 落合智子, Joint work, 61-69, 落合邦康、マーニE. クエノ、落合智子
    医薬ジャーナル社, Feb. 2018
  • 口腔内フローラと腸内フローラ
    落合邦康; 落合智子, Joint work, 落合邦康、落合智子
    ライフ・サイエンス, Jun. 2017
  • 腸内細菌・口腔細菌と全身疾患:歯周病で誘導される動脈硬化と酸化ストレス
    落合邦康; 落合智子他, Joint work, 168-175, 落合邦康、落合智子他
    シーエムシー出版, Dec. 2015, Not refereed
  • 口腔微生物学―感染と免疫ー、第5版
    石原和幸; 落合智子他, Joint work, 216-271, 石原和幸、落合智子他
    学建書院, Sep. 2015, Not refereed
  • 口腔環境と全身疾患の関係: 歯周病と動脈硬化
    落合智子他, Joint work, 59-64, 落合智子他
    シーエムシー出版, Apr. 2015, Not refereed
  • 消化管の栄養・生理と腸内細菌
    石塚敏; 落合智子他, Joint work, 1-18, 石塚敏、落合智子他
    Hindgut Club Japan, Apr. 2011, Not refereed
  • 分子生物学歯科小辞典
    Joint work
    口腔保健協会, Jun. 2003, Not refereed
  • 嫌気性菌代謝産物・脂肪酸の為害作用:繊維芽細胞のアポトーシス誘導
    落合邦康; 阿部和正; 栗田智子, Joint work, 落合邦康、阿部和正、栗田智子
    日本消化器免疫学会, Apr. 2003, Not refereed
  • Effect of periodontopathic bacteria on secondary immunoresponse and isotype switching.
    Ochiai, K; Kurita-Ochiai, T; Ikeda, T, Joint work, Ochiai; K.; Kurita-Ochiai; T.; and Ikeda
    Elsevier Science Publisher, Oct. 1991, Not refereed
  • T cell networks for regulation of the mucosal immune system.
    Kiyono, H; Kitamura, K; Kurita-Ochiai, T; McGhee, J.R, Joint work, Kiyono; H.; Kitamura; K.; Kurita-Ochiai; T.; and McGhee; J.R.
    Anali Sclavo, Jun. 1988, Not refereed
  • IgA-specific regulatory T cells in the mucosal immune system. In Mucosal immunity and infections at mucosal surfaces.
    Kiyono, H; Kurita-Ochiai, T; Suzuki, I; Eldridge, J.H; Morrison, G.F; McGhee, J.R, Joint work, Kiyono; H.; Kurita-Ochiai; T.; Suzuki; I.; Eldridge; J.H.; Morrison; G.F.; and McGhee; J.R.
    Oxford Univ. Press, Apr. 1988, Not refereed
  • Isotype-specific immunoregulation: T contrasuppressor cells protect IgA responses in roal tolerance.
    Kitamura, K; Kiyono, H; Suzuki, I; Kurita-Ochiai, T; Berry, K.A; Green, D.R; McGhee, J.R, Joint work, Kitamura; K.; Kiyono; H.; Suzuki; I.; Kurita-Ochiai; T.; Berry; K.A.; Green; D.R. and McGhee; J.R.
    Adv. Exp. Med. Biol., Apr. 1987, Not refereed
  • Regulatory T cell networks in the secretory immune system
    Eldridge, J.H; Kiyono, H; Suzuki, I; Kitamura, K; Kurita-Ochiai, T; Beagly, K.W; McGhee, M.L; Michalek, S.M; McGhee, J.R, Joint work, Eldridge; J.H.; Kiyono; H.; Suzuki; I.; Kitamura; K.; Kurita-Ochiai; T.; Beagly; K.W.; McGhee; M.L.; Michalek; S.M.; and McGhee; J.R.
    Adv. Exp. Med. Biol., Apr. 1987, Not refereed
  • Regulation of IgA responses to type 1 and type 2 Streptococcus mutans. In Molecular Microbiology and Immunology of Streptococcus mutans
    Kiyono, H; Kimura, S; Koga, T; Kurita-Ochiai, T; Eldridge, J.H; Michalek, S.M; Hamada, S; McGhee, J.R, Joint work, Kiyono; H.; Kimura; S.; Koga; T.; Kurita-Ochiai; Eldridge; J.H.; Michalek; S.M.; Hamada; S. and McGhee; J.R.
    Elsevier Science Publisher, Oct. 1986, Not refereed
  • Induction and T cell regulation of IgA responses to Streptococcus mutans antigens.
    Kiyono, H; Czerkinsky, C; Koga, T; Kimura, S; Kurita-Ochiai, T; Michalek, S.M; Mestecky, J; Hamada, S; McGhee, J.R, Joint work, Kiyono; H.; Czerkinsky; C.; Koga; T.; Kimura; S.; Kurita-Ochiai; Michalek; S.M.; Mestecky; J.; Hamada; and McGhee; J.R.
    Editions Medicine et Hygiene, Sep. 1986, Not refereed
  • The boderland and between caries and periodontal disease III: Induction and T cell regulation of IgA response to Streptococcus mutans antigens
    Joint work
    Editions Medicine et Hygiene, Sep. 1986, Not refereed
  • Neosugar P及びHSFのう蝕原性
    Joint work
    Neosugar 研究会, Apr. 1984, Not refereed
  • Nystoseの齲蝕原性
    Joint work
    Neosugar研究会, Apr. 1982, Not refereed
  • Streptococcus mutans産生Bacteriocinの抗齲蝕作用
    Joint work
    1982, Not refereed
  • Coupling sugar8種超製品からの酸産生とラット実験齲蝕およびICT法によるGlucosylsucrose, Maltosylsucroseの齲蝕原性
    Joint work
    国立予研歯科衛生部, Apr. 1980, Not refereed

Lectures, oral presentations, etc.

  • Streptococcus sobrinus誘発性う蝕の抑制におけるIgA抗体の役割¥
    瀧澤智美、齋藤真規、桒原紀子、小林良喜、落合智子
    第94回日本細菌学会, Mar. 2021, Not invited
  • GroELを用いた経鼻ワクチンによる歯周病抑制効果の検討
    Chang E; 小林良喜、落合智子
    第62回歯科基礎医学会学術大会, Sep. 2020, Not invited
  • 腸管を起点とした口腔免疫機能を活性化させる液性因子の探索
    小林良喜、瀧澤智美、落合智子
    第62回歯科基礎医学会学術大会, Sep. 2020, Not invited
  • 羅漢果抽出液の口腔微生物に対する抗菌効果の基礎的研究
    斎藤真規、桑原紀子、瀧澤智美、落合智子
    第62回歯科基礎医学会学術大会, Sep. 2020, Not invited
  • 健常学生の唾液由来におけるStreptococcus sobrinusの分布状況
    桑原紀子、斎藤真規、瀧澤智美、小林良喜、落合智子
    第62回歯科基礎医学会学術大会, Sep. 2020, Not invited
  • 歯周炎における歯周病原菌Fusobacterium nucleatumおよびPorphyromonas gingivalisの混合投与の影響
    戸田みゆき、河野哲朗、小林良喜、渡辺新、玉村亮、落合智子、岡田裕之
    第62回歯科基礎医学会学術大会, Sep. 2020, Not invited
  • Oral infection with Streptococcus sanguinis accelerates atherosclerosis inhyperlipidemic mice
    瀧澤智美、山口陽平、小林良喜、桑原紀子、斎藤真規
    第93回日本細菌学会総会, Feb. 2020, Not invited
  • IL-10 modulates alveolar formation in murine periodontal tissue
    The 48th Annual Meeting of The Japanese Society for Immunology, Dec. 2019, Not invited
  • Intragastric administration of Lactobacillus helveticus SBT2171 controls Porphyromonas gingivalis-induced inflammation and bone resorption
    Kobayashi R; Kobatake E; Kabuki T; Kurita-Ochiai T.
    17th International Congress of Immunology, Oct. 2019, Not invited
  • 歯周病原細菌Fusobacterium nucelatumの骨吸収および歯周組織炎症への関与
    小川泰宏、小林良喜、河野哲郎、岡田裕之、落合智子、小宮正道
    第61回歯科基礎医学会学術大会, Oct. 2019, Not invited
  • 健常学生の鼻腔におけるStaphylococcus aureusの保有状況
    桑原紀子、斎藤真規、瀧澤智美、小林良喜、落合智子
    第61回歯科基礎医学会学術大会, Oct. 2019, Not invited
  • 歯周病原菌が動脈硬化に及ぼす影響と予防戦略
    落合智子
    第61回歯科基礎医学会学術大会, Oct. 2019, Not invited
  • Lactobacillus helveticus SBT2171 induces β-defensin expression and ameliorates periodontal disease caused by Porphyromonas gingivalis
    Kobatake E; Kobayashi R; Kabuki T; Kurita-Ochiai T.
    IDF World Daily Summit, Sep. 2019, Not invited
  • 歯周病原細菌Fusobacterium nucleatumによる口腔および腸管免疫機構への影響
    小川泰宏、小林良喜、河野哲郎、岡田裕之、落合智子、小宮正道
    第19回日本大学口腔科学会学術大会, Sep. 2019, Not invited
  • 唾液中抗菌物質を用いた高齢者に対するCandida albicans感染予防のための基礎的研究 唾液中抗菌物質濃度と作用時間の違いがCandida albicansに対する抗菌効果に及ぼす影響についての検討
    目黒郁美、小野仁徳、小林良喜、渡邊丈紘、砂治大介、落合智子、河相安彦
    第19回日本大学口腔科学会学術大会, Sep. 2019, Not invited
  • 抗菌ガラス添加型ポリエーテルケトンの曲げ特性および真菌の付着能に関する検討
    吉崎聡、斎藤真規、桑原紀子、浅野隆、落合智子、小見山道
    第19回日本大学口腔科学会学術大会, Sep. 2019, Not invited
  • O3-2 prevent periodontitis via intestinal tract.
    Kobayashi R; Hashizume-Takizawa T; Kurita-Ochiai T.
    97th International Association for Dental Research, Jun. 2019, Not invited
  • Induction of gut dysbiosis and turbulence of intestinal immune system by oral bacteria
    Kurita-Ochiai T; Kobayashi R.
    97th International Association for Dental Research, Jun. 2019, Not invited
  • Salivary SIgA regulates oral dysbiosis and subsequent bone resorption
    Chang E; Kobayashi R; Hagiwara M; Fujihashi K; Komiya M; Kurita-Ochiai T.
    97th International Association for Dental Research, Jun. 2019, Not invited
  • Lactobacillus helveticua SBT2171によるβ-defensin発現上昇作用およびPorphyromonas gingivalis感染防御作用
    小畠英史、小林良喜、冠木敏秀、落合智子
    第73回日本栄養食糧学芸大会, May 2019, Not invited
  • Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss.
    6.Emily Chang; Ryoki Kobayashi; Mio Hagiwara; Kohtaro Fujihashi; Masamichi Komiya; Tomoko Kurita-Ochiai.
    The 47th Annual Meeting of The Japanese Society for Immunology., Dec. 2018, Not invited
  • 歯周病原性細菌の動脈硬化に及ぼす影響
    落合智子
    第24回 Hindgut Club JAPAN シンポジウム, Dec. 2018, Invited
  • 歯周病原菌の動脈硬化に及ぼす影響
    落合 智子
    第24回Hindgut Club JAPANシンポジウム, Dec. 2018, Invited
  • Oral microbiome induce gut dysbiosis and affect gut Th17/Treg axis, M1/M2 balance, and IgA production
    Kurita-Ochiai T; Kobayashi R.
    EMBO/EMBL Symposia, Sep. 2018, Not invited
  • Streptococcus sanguinis, Streptococcus anginosus 感染が動脈硬化発症に与える影響
    瀧澤智美、小林良喜、桑原紀子、斎藤真規、續橋治、落合智子
    第60回歯科基礎医学会学術大会, Sep. 2018, Not invited
  • 歯周病原性黒色集落嫌気性桿菌群の増殖培地の検討
    2.斎藤真規、桑原紀子、瀧澤智美、落合智子
    第60回歯科基礎医学会学術大会, Sep. 2018, Not invited
  • ヒト唾液から分離された新規Leptotrichia属菌の提唱
    桑原紀子、斎藤真規、瀧澤智美、小林良喜、落合智子
    第60回歯科基礎医学会学術大会, Sep. 2018, Not invited
  • Lactobacillus gasseri O3-2による腸管を介した歯槽骨吸収抑制効果の検討
    小林良喜、瀧澤智美、落合智子
    第60回歯科基礎医学会学術大会, Sep. 2018, Not invited
  • 歯科用チェアユニット給水システムにおけるナノバブル水の応用に関する研究
    田口千恵子、有川量崇、斎藤真規、小林良喜、内山敬一、後藤田宏也、落合智子、金田隆
    第18回日本大学口腔科学会学術大会, Sep. 2018, Not invited
  • 口腔常在細菌が全身疾患にである動脈硬化に与える影響についての検討
    瀧澤智美、小林良喜、桑原紀子、斎藤真規、續橋治、福本雅彦、落合智子
    第18回日本大学口腔科学会学術大会, Sep. 2018, Not invited
  • 脂質代謝異常が歯槽骨吸収に与える影響
    小林良喜、瀧澤智美、有川量崇、田口千恵子、後藤田宏也、落合智子
    第18回日本大学口腔科学会学術大会, Sep. 2018, Not invited
  • 口腔感染症制御による健康長寿社会実現に向けて
    落合 智子
    第18回日本大学口腔科学会学術大会, Sep. 2018, Not invited
  • Lactic acid bacteria regulate Foxp3+ Treg cells for prevent periodontal diseases.
    Ryoki Kobayashi; Tomoko Kurita-Ochiai.
    第91回日本細菌学会総会, Mar. 2018, Not invited
  • Analysis of caries-related gene expression levels of mutans group streptococci.
    Noriko Kuwahara; Masanori Saito; Osamu Tsuzukibashi; Ryoki Kobayashi; Tomoko Ochiai.
    第91回日本細菌学会総会, Mar. 2018, Not invited
  • Isolation method of Seardovia wiggsiae and relationship with adult dental caries.
    Osamu Tsuzukibashi; Satoshi Uchibori; Masanori Saito; Noriko Kuwahara; Tomoko Ochiai.
    第91回日本細菌学会総会, Mar. 2018, Not invited
  • Identification of novel species of genus Actinomyces isolated from Japanese serow oral cavities.
    16.Masanori Saito; Noriko Shinozaki-Kuwahara; Osamu Tsuzukibashi; Ryoki Kobayashi; Tomoko Kurita-Ochiai.
    第91回日本細菌学会総会, Mar. 2018, Not invited
  • ロジンを含有した歯のコーテイング剤による歯周病原細菌に対する抗菌効果の調査
    續橋治、瀧澤智美、和田幸子、浦井 薫子、落合智子
    日本歯周病学会60周年記念京都大会, Dec. 2017, Not invited
  • Characterization of innate lymphoid cells in inflamed gingiva of mice infected with Porphyromonas gingivalis
    Ryoki Kobayashi; Yohei Watanabe; Noriko M Tsuji; Keiji Hirota; Tomoko Kurita-Ochiai
    第46回日本免疫学会学術集会, Dec. 2017, Not invited
  • 口臭簡易キットの開発と口臭に関わる細菌の検索
    7.續橋治、内堀聡史、斎藤真規、小林良喜、瀧澤智美、桑原紀子、落合智子
    第59回歯科基礎医学会学術大会, Sep. 2017, Not invited
  • 脂質代謝異常による腸管Dysbiosisと歯槽骨吸収への影響
    小林良喜、落合智子
    第59回歯科基礎医学会学術大会, Sep. 2017, Not invited
  • 口臭に関わる細菌の検索と口臭簡易検出キットの臨床応用
    續橋治、斎藤真規、桑原紀子、小林良喜、瀧澤智美、落合智子
    第17回日本大学口腔科学会学術大会, Sep. 2017, Not invited
  • Poly-L-lysine dendrigraft固定化顎骨再生PLAフィルムの開発
    布施恵、深津晶、小倉由希、小西賀美、小峯千明、渕上真奈、瀧澤智美、落合智子、福本雅彦
    第17回日本大学口腔科学会学術大会, Sep. 2017, Not invited
  • Peyer's patch B cells play distinct roles for induction of antigen-specific intestinal IgA antibody responses against orally administered recombinant Salmonella
    4.T.Hashizume-Takizawa; K.Fujihashi; JR.McGhee; Y.Kurashima; N.Shibata; H.Kiyono; T.Kurita-Ochiai
    18th International Congress of Mucosal Immunology, Jul. 2017, Not invited
  • 歯周病原菌代謝産物・酪酸の加齢促進作用とアルツハイマー症誘導能の可能性
    落合邦康、塚原隆充、落合智子
    第21回腸内細菌学会, Jun. 2017, Not invited
  • 歯周病原菌代謝産物酪酸の作用:酪酸の加齢促進作用とアルツハイマー誘導性
    落合邦康、落合智子
    第60回春季日本歯周病学会学術大会, May 2017, Not invited
  • 口腔常在菌Veilonella parvulaによる腸管免疫機構への影響
    小林良喜、小川泰宏、落合智子
    第60回春季日本歯周病学会学術大会, May 2017, Not invited
  • Lactic acid bacteria prevent both periodontitis and atherosclerosis
    Kobayashi R; Hashizume-Takizawa T; Saito M; Tsuzukibashi O; Shinozaki- Kuwahara N; Kurita-Ochiai T
    第 90 回日本細菌学会総会, Mar. 2017, Not invited
  • Red complex 細菌である P. gingivalis および T. forsythia の分離方法
    續橋治; 内堀聡史; 齋藤真規; 桒原紀子; 落合智子
    第 90 回日本細菌学会総会, Mar. 2017, Not invited
  • Streptococcus dentiloxodontae が産生する不溶性多糖体 合成酵素の検索
    桒原紀子; 齋藤真規; 續橋治; 落合智子
    第 90 回日本細菌学会総会, Mar. 2017, Not invited
  • S. dentiloxodontae sp. nov., isolated from the oral cavity of elephants
    Saito M; Shinozaki-Kuwahara N; Tsuzukibashi O; Kurita-Ochiai T
    第 90 回日本細菌学会総会, Mar. 2017, Not invited
  • Influence of strain difference on change of gut microflora and gut immune system induced by periodontal pathogen
    Kobayashi Ryoki; Hagiwara Mio; Tomoko Ochiai
    第45回日本免疫学会学術集会, Dec. 2016, Not invited
  • Streptococcus ferus cariogenic factor遺伝子の検索
    桑原 紀子; 齋藤 真規; 續橋 治; 小林 良 喜; 瀧澤 智美; 落合 智子
    第58回歯科基礎医学会学術大会, Aug. 2016, Not invited
  • Actinomyces israeliiの分離培養選択培地の開発とその口腔内分布
    續橋 治; 内堀 聡史; 齋藤 真規; 小林 良 喜; 瀧澤 智美; 桑原 紀子; 落合 智子
    第58回歯科基礎医学会学術大会, Aug. 2016, Not invited
  • ヒト歯肉溝から分離された赤色集落を呈する新菌種Propionibacterium gingivaerubrumの解析
    齋藤 真規; 桑原 紀子; 續橋 治; 瀧澤 智 美; 小林 良喜; 落合 智子
    第58回歯科基礎医学会学術大会, Aug. 2016, Not invited
  • Involvement of NLRP3 inflammasome in P. gingivalis-accelerated atherosclerosis and periodontal disease
    Kurita-Ochiai T; Yamaguchi Y; Kobayashi R; Ando T
    International Congress of Immunology, Aug. 2016, Not invited
  • マウスにおける分泌型IgA抗体産生の概日リズム
    田口千重子、小林良喜、有川量崇、中山竜司、落合智子、那須郁夫
    第65回日本口腔衛生学会・総会, May 2016, Not invited
  • 歯周炎モデルマウスを用いた歯肉炎症巣におけるexosome分泌の計時的変化の検討
    小林 良 喜; 落合 智子
    第59回春季日本歯周病学会学術大会, May 2016, Not invited
  • ジンジパインと酸化LDLとのエピトープ交差反応性
    落合智子、瀧澤智美、小林良喜
    第59回春季日本歯周病学会学術大会, May 2016, Not invited
  • 口腔細菌が腸内フローラ及び腸管免疫系に及ぼす影響
    落合 智子; 小林 良喜; 齋藤 真規; 續橋 治; 桒原 紀子
    日本細菌学会総会, Mar. 2016, Not invited
  • フサオマキザル口腔から分離された新菌種Streptococcus oricebiの解析
    齋藤 真規; 續橋 治; 桒原 紀子小林 良喜; 落合 智子
    日本細菌学会総会, Mar. 2016, Not invited
  • 口腔Rothia属菌選択培地の開発とその口腔内分布
    續橋 治; 内堀 聡史; 齋藤 真規; 小林 良 喜; 桒原 紀子; 落合 智子
    日本細菌学会総会, Mar. 2016, Not invited
  • Streptococcus dentasiniが産生する非水溶性グルカン合成酵素遺伝子の解析
    桒原 紀子; 齋藤 真規; 續橋 治; 小林 良 喜; 髙田 和子; 落合 智子
    日本細菌学会総会, Mar. 2016, Not invited
  • Inductions of CD63 expressing mast cells in inflamed gingival of periodontal disease mouse model.
    Kobayashi Ryoki; Fujihashi Kohtaro; Tomoko Ochiai
    日本免疫学会総会, Nov. 2015, Not invited
  • Regulation of junctional epithelial relative gene in inflamamtion
    Nakayama Y.; R. Kobayashi; S. Matsui; H. Matsumura; Y. Iwai; K. Noda; M. Yamazaki; T. Ochiai-Kurita; A. Yoshimura; B. Ganss; and Y. Ogata
    Japanese Association of Dental Research, Oct. 2015, Not invited
  • プロバイオティクス乳酸菌Lactobacillus gasser SBT2055による腸管免疫機構を起点とした口腔免疫機構の活性化
    日本食品免疫学会, Oct. 2015, Not invited
  • Porphyromonas gingivalisで増悪する動脈硬化および歯周病におけるNLRP3インフラマソームの活性化
    落合智子、小林良喜、瀧澤智美、桒原紀子、續橋治、斎藤真規
    歯科基礎医学会学術大会, Sep. 2015, Not invited
  • 概日リズムに依存した分泌型IgA抗体誘導径鼻ワクチン投与
    小林良喜、桒原紀子、續橋治、斎藤真規、落合智子
    歯科基礎医学会学術大会, Sep. 2015, Not invited
  • A. actinomycetemcomitansj簡易検出キットの開発と臨床応用
    續橋治、桒原紀子、斎藤真規、瀧澤智美、小林良喜、落合智子
    歯科基礎医学会学術大会, Sep. 2015, Not invited
  • 歯周ポケットから分離された赤色色素産生性新規Propionibacerium属菌の解析
    斎藤真規、桒原紀子、續橋治、小林良喜、瀧澤智美、落合智子
    歯科基礎医学会学術大会, Sep. 2015, Not invited
  • Aggregatibacter actinomycetemcomitans血清型gのゲノム解析
    桒原紀子、斎藤真規、續橋治、瀧澤智美、小林良喜、落合智子
    歯科基礎医学会学術大会, Sep. 2015, Not invited
  • 老化の病因の基礎となる生物学的解析
    バワールウジャール、小林良喜、落合智子、平塚浩一
    日本炎症・再生医学会, Jul. 2015, Not invited
  • Characterization of mast cell in inflamed gingiva in mouse model.
    Kobayashi R; K. Fujihashi and T. Ochiai
    International Congress of Mucosal Immunology, Jul. 2015, Not invited
  • Distinct responses of transcription factor DEC1 to senescence and implications for aging
    Ujjal Bhawal; Ryoki Kobayashi; Hye-Jin Lee; Tomoko Kurita-Ochiai; Koichi Hiratsuka
    日本骨免疫学会, Jul. 2015, Not invited
  • 歯周病モデルマウスを用いた口腔粘膜免疫機構の解明
    小林良喜、藤橋浩太郎、山本正文、落合智子
    内毒素・LPS研究会, Jun. 2015, Invited
  • Lipopolysaccharide regulating amelotin gene transcription in gingival epithelial cells and amelotin protein localization in inflamed gingiva.
    Nakayama Y.; Kobayashi R.; Matsui S.; Matsumura H.; Kurita-Ochiai T.; Yoshimura A.; Ganss B.; Ogata Y.
    EuroPerio 8, London, Uk, Jun. 2015, Not invited
  • 日内変動による経鼻ワクチンによる特異抗体産生誘導の検討
    小林良喜、有川量崇、田口千恵子、那須郁夫、落合智子
    日本口腔衛生学会総会, May 2015, Not invited
  • Adjuvant-free sublingual vaccine using GroEL attenuate Porphyromonas gingivalis-induced atherosclerosis
    萩原美緒、落合智子、小宮正道
    日本口腔科学会学術集会, May 2015, Not invited
  • Porphyromonas gingivalis誘導性動脈硬化発症および進展におけるNLRP3インフラマソームシグナルの役割
    山口陽平、落合智子、安藤智博
    日本口腔科学会学術総会, May 2015, Not invited
  • Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis and periodontal disease
    Yamaguchi Y; Kobayashi R; Hashizume-Takizawa T; Ando T; and Kurita-Ochiai T.
    International Association for Dental Research, Mar. 2015, Not invited
  • Activation of NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis and periodontal disease
    Yamaguchi Yohei; Ochiai Tomoko; Kobayashi Ryoki; Hashizume Tomomi; Ando Tomohiko
    Annual Meeting of The Japanese Society for Immunology, Dec. 2014, Not invited
  • Daily rhythms influences antigen-specific immunoresponsewith nasal immunization
    Kobayashi Ryoki; Arikawa Kazumune; Taguchi Chieko; Yamamoto Masafumi; Kurita-Ochiai Tomoko
    The Annual Meeting of The Japanese Society for Immunology, Dec. 2014, Not invited
  • Fox3+ Treg cell in Gut-Oral by Probiotic bacterium reduced alveolar bone loss in mouse model
    Ryoki Kobayashi; Tomomi Hashizume; Masafumi Yamamoto; Tomoko Ochiai
    日本分子生物学会, Nov. 2014, Invited
  • リポポリサッカライドによるアメロチニン遺伝子発現の変化
    中山洋平、松井沙莉、松村浩禎、加藤彩子、高井英樹、落合智子、小方頼昌
    日本歯周病学会, Oct. 2014, Not invited
  • ミダゾラムによるIgE抗体クラススイッチ組換えの制御
    草間弘朝、落合智子、下坂典立、藤田裕、石川学、渋谷鉱
    日本歯科麻酔学会総会, Oct. 2014, Not invited
  • 歯周病原菌Aggregatibacter actinomycetemcomitans GFP変異株の作製
    瀧澤智美、桒原紀子、落合智子
    歯科基礎医学会, Sep. 2014, Not invited
  • LDL酸化変性におけるArg-及びLys-gingipainの役割
    落合智子、瀧澤智美、小林良喜
    歯科基礎医学会, Sep. 2014, Not invited
  • プロバイオティクス乳酸菌による腸管免疫を介した歯周病抑制
    Kobayashi R; Sakai F; Hosoya T; Yamamoto M; and Ochiai T.
    遺伝子栄養研究会, Sep. 2014, Not invited
  • Association of inflammasome in periodontal disease and atherosclerosis induced by Porphyromonas gingivalis oral infection
    Yohei Yamaguchi; Tomoko Ochiai; Tomomi Hashizume; Ryoki Kobayashi; Tomohiro Ando
    Annual Meeting Scientific Sessions & Exhibition, Sep. 2014, Not invited
  • Basic helix-loop-helix transcription factors DEC1 and DEC2 modulates P. gingivalis-induced inflammation
    Ujjal Bhwal; 小林良喜、落合智子
    日本炎症・再生医学会, Jul. 2014, Not invited
  • Characterization of RANKL+CD4+ T cell in inflamed gingiva of periodontal disease mouse model
    Kobayashi R; Fujihashi K; Yamamoto M; and Ochiai T.
    Japanese Conference on Osteoimmunology, Jul. 2014, Not invited
  • 納豆摂取における歯肉粘膜からの抗菌ペプチドの発現
    有川量宗、小林良喜、田口千恵子、中山竜司、生田明敏、落合智子、那須郁夫
    日本口腔衛生学会, May 2014, Not invited
  • 発酵食品(納豆)による口腔免疫賦活効果
    小林良喜、有川量宗、田口千恵子、那須郁夫、落合智子
    日本口腔衛生学会, May 2014, Not invited
  • Porphyromonas gingivalis口腔感染で誘導される歯周病および動脈硬化におけるinflammasomeの関与
    山口陽平、落合智子、安藤智博
    日本口腔科学会, May 2014, Not invited
  • Inflamed gingiva derived CD103 negative dendritic cell are differentiate to Foxp3+ Treg cell in periodontal disease mouse model.
    R. Kobayashi; M. Yamamoto; K. Fujihashi; T. Ochiai
    The American Association of Immunologists AAI Annual Meeting, May 2014, Not invited
  • Inflamed gingiva derived CD11c+ dendritic cell induced Foxp3+ Treg cell
    Kobayashi Ryoki; Kurita-Ochiai Tomoko; Hashizume Tomomi; Fujihashi Kotaro; Yamamoto Masafumi
    Annunal Meeting of The Japanese Society for Immunology, Dec. 2013, Not invited
  • Peyer's patch lymphocytes are distinctive in the induction of antigen-specific intestinal mucosal IgA antibody responses against recombinant Salmonella
    Hashizume-Takizawa Tomomi; Ochiai Tomoko; Yamamoto Masafumi
    Annual Meeting of The Japanese Society for Immunology, Dec. 2013, Not invited
  • Sublingual immunization with GroEL induce antigen-specific regulatory T cells and reduces bacteria-induced atherosclerosis
    Hagiwara Mio; Kurita-Ochiai Tomoko; Kobayashi Ryoki; Hashizume-Takizawa Tomomi; Yamamoto Masafumi
    Annual Meeting of The Japanese Society for Immunology, Dec. 2013, Not invited
  • Probiotics bacterium Lactobacillus gasseri SBT2055-induced β-defensin prevent periodontal diseases in mouse model
    Ryoki Kobayashi; Tomoko Kurita-Ochiai; Toshiya Kobayashi; Masafumi Yamamoto
    World Daily Summit, Oct. 2013, Not invited
  • Significant expression of β-defensin on oral mucosa by administration of probiotic bacterium, Lactobacillus gasseri SBT2055
    小林良喜、門岡幸男、落合智子
    日本食品免疫学会, Oct. 2013, Not invited
  • Porphyromonas gingivalis口腔感染により進展する動脈硬化におけるインフラマソームの関与
    山口陽平、落合智子、小林良喜、瀧澤智美、安藤智博
    日本歯周病学会, Sep. 2013, Not invited
  • プロバイオテイクス乳酸菌Lactobacillus cripatus (KT-11)による歯周組織における抗炎症性効果
    田口千恵子、小林良喜、有川量宗、飛田啓輔、斎藤真規、落合智子、那須郁夫
    日本歯周病学会, Sep. 2013, Not invited
  • Sublingual vaccination with Porphyromonas gingivalis GroEL elicits protective immunity against atherosclerosis
    M. Hagiwara; T. Kurita-Ochiai; R. Kobayashi; T. Hashizume-Takizawa; M. Yamamoto
    International Congress of Immunology, Aug. 2013, Not invited
  • Lymphocytes activated in the Peyer's patches, but not in other lymphoid tissues, are essential for intestinal IgA responses against recombinant Salmonella
    Tomomi Hashizume-Takizawa; Tomoko Kurita-Ochiai; Masafumi Yamamoto
    International Congress of Mucosal Immunology, Jul. 2013, Not invited
  • Probiotic bacterium, Lactobacillus gasseri SBT2055-induced β-defensin prevents Porphyromonas gingivalis-mediated periodontal disease
    Ryoki Kobayashi; Tomoko Ochiai; Toshiya Kobayashi; Masafumi Yamamoto
    International Congress of Mucosal Immunology, Jul. 2013, Not invited
  • 口腔内短鎖脂肪酸の歯周病と全身疾患に及ぼす影響
    落合邦康、今井健一、落合(栗田)智子
    腸内細菌学会, Jun. 2013, Invited
  • 歯周病と動脈硬化―モデル動物を用いての検討.
    落合智子
    日本生理学会, Mar. 2013, Not invited
  • 歯周病原菌代謝産物・酪酸の歯周組織に及ぼす影響と潜伏感染ウイルスの再活性化.
    落合邦康、今井健一、落合智子.
    日本細菌学会, Mar. 2013, Not invited
  • Adjuvant-free sublingual vaccne using GroEL attenuates Porphyromonas gingivalis-induced atherosclerosis.
    Hagiwara; M.; Oguchi; S.; Kurita-Ochiai; T.
    日本循環器学会, Mar. 2013, Not invited
  • Functional imbalance between Th17, Th1, and Treg cells in A. actinomycetemcomitans-accelerated atherosclerosis.
    Jia; R.; Oguchi; S.; Kurita-Ochiai; T.
    日本循環器学会, Mar. 2013, Not invited
  • Severe periodontal tissue damaged by Aggregatibacter actinomycetemcomitans in mouse model.
    Kobayashi; R.; Ochiai; T.; Hashizume; T.; Fujihashi; K.; Yamamoto; M.
    日本免疫学会総会, Dec. 2012, Not invited
  • Sublingual immunization with GroEL attenuates Porphyromonas gingivalis-induced atherosclerosis.
    Hagiwara; M.; Hashizume-Takizawa; T.; Kurita-Ochiai; T.; Yamamoto; M.
    日本免疫学会総会, Dec. 2012, Not invited
  • Anti-inflammatory effect of probiotic bacterium, Lactobacillus gasseri SBT2055 to periodontal diseases.
    小林良喜、落合智子.
    日本食品免疫学会, Oct. 2012, Not invited
  • 動脈硬化進展への歯周治療の効果.
    吉野祥一、大口純人、落合智子、目澤優、高井英樹、鈴木桃子、小山朱美、大橋顕ニ郎、岡野千春、井上文央、坂巻達夫、小方頼昌.
    日本歯周病学会, Sep. 2012, Not invited
  • Probiotic bacterium, Lactobacillus gasseri SBT2055 can enhance antigen-specific immune responses in oral mucosa.
    Kurita-Ochiai; T.; Kobayashi; T.; Yamamoto; M.
    European congress of immunology, Sep. 2012, Not invited
  • Effect of Th17/Th1/Treg balance and microRNA expression in A. actinomycetemcomitans-accelerated atherosclerosis.
    Jia; R.; Ochiai; T.; Yamamoto; M.
    European congress of immunology, Sep. 2012, Not invited
  • Oxidative modification of lipoprotein by periodontopathic bacteria.
    Kurita-Ochiai; T.; Jia; R.; Hashizume; T.; Yamamoto; M.
    European congress of immunology, Sep. 2012, Not invited
  • 歯周科治療による動脈硬化の進展への効果.
    吉野祥一、大口純人、落合智子、橋爪智美、目澤優、高井英樹、鈴木桃子、小山朱美、大橋顕ニ郎、岡野千春、中尾寿美、井上文央、坂巻達夫、小方頼昌.
    日大口腔科学会, Sep. 2012, Not invited
  • Midazolam inhibits production of surface IgE antibody of B cells.
    Kusama. H.; Kobayashi; R.; Hashizume-Takizawa; T.; Yuzawa; S.; Kurita-Ochiai; T.; Yamamoto; M.; Shibutani; K.
    International Association for Dental Research, Jun. 2012, Not invited
  • Inductiuon of Foxp3+CD4+ Treg cell by inflammatory-induced gingival dendritic cells.
    Kobayashi; R.; Yuzawa; S.; Hashizume-Takizawa; T.; Kurita-Ochiai; T.; Yamamoto; M.
    International Association for Dental Research, Jun. 2012, Not invited
  • Epigallocatechin-3-gallate reduces atherosclerosis exacerbated by Porphyromonas gingivalis.
    Cai; Y.; Hashizume; T.; Kurita-Ochiai; T.; Yamamoto; M.
    International Association for Dental Research, Jun. 2012, Not invited
  • Association of serum antibodies to Porphyromonas gingivalis HSP60 and atherosclerosis.
    Hagiwara; M.; Hashizume-Takizawa; T.; Kurita-Ochiai; T.; Suemitsu; M.; Kuyama; K.; Yamamoto; H.; Akimoto; Y.; Yamamoto; M.
    International Association for Dental Research, Jun. 2012, Not invited
  • Porphyromonas gingivalis contributers to oxidation of low-density lipoprotein
    Jia R; Ochiai T; and Yamamoto M.
    春季歯周病学会, May 2012, Not invited
  • Emerging function of Th17 responses for development of atherosclerosis infected by Porphyromonas gingivalis
    Cai Y; Hashizume T; Kobayashi R; Ochiai T; and Yamamoto M.
    春季歯周病学会, May 2012, Not invited
  • Nasal vaccine against outer membrane protein of periodontal bacteria suppressed the bacteria-induced atherosclerosis
    Oguchi S; Sakamaki T; Kurita-Ochiai T; Inoue F; and Nagao K.
    日本循環器学会, Mar. 2012, Not invited
  • Intravenous anesthetic midazolam inhibits IgE antibody synthesis
    Kusama H; Kobayashi R; Yuzawa S; Ochiai T; Yamamoto M; and Shibutani K.
    International Dental Congress on Anesthesia, Sedation and Pain Control, Mar. 2012, Not invited
  • 歯周病原菌代謝産物・酪酸の微生物間相互作用−潜伏感染ウイルスの再活性化とガン進展に及ぼす影響ー
    落合邦康、今井健一、落合智子
    日本臨床微生物学会, Jan. 2012, Not invited
  • Porphyromonas gingivalisによる低比重リポタンパクの酸化変性
    Kurita-Ochiai T; Hashizume T; and Yamamoto M.
    日本免疫学会, Nov. 2011, Not invited
  • Porphyromonas gingivalis 由来のheat-shock protein 特異的免疫応答による動脈硬化の誘導.
    荻原美緒、橋爪智美、落合智子、秋元芳明、山本正文.
    歯科基礎医学会.学術総会, Oct. 2011, Not invited
  • Porphyromonas gingivalis のhemagglutinin A抗原領域とマルトース結合タンパクの複合タンパク質の舌下免疫による抗原特異的抗体応答誘導.
    湯澤仁、橋爪智美、落合智子、安孫子宜光、山本正文.
    秋季歯周病学会, Sep. 2011, Not invited
  • Porphyromonas gingivalis 感染による動脈硬化マウスモデルの検討.
    深澤飛鳥、橋爪智美、落合智子、秋元芳明、山本正文.
    秋季歯周病学会, Sep. 2011, Not invited
  • Green tea epigallocatechin-3-gallate reduces atherosclerosis exacerbated by P.gingivalis.
    Cai Y.; Hashizume T.; Kurita-Ochiai T.; Yamamoto M.
    Japanese Society of Pediodontology, Sep. 2011, Not invited
  • Aggregatibacter actinomycetemcomitans-sensitized monocytes induce endothelial cell apoptosis.
    Kurita-Ochiai; T.; Hashizume; T.; Yamamoto; M.
    International Association for Dental Research, Mar. 2011, Not invited
  • Aggregatibacter actinomycetemcomitans infection accelerates atherosclerosis through LDL oxidation.
    Jia; R.; Kurita-Ochiai; T.; Hashizume; T.; Yamamoto; M.
    nternational Association for Dental Research, Mar. 2011, Not invited
  • Porphyromonas gingivalis infection enhances TH17 responses for development of atherosclerosis.
    Cai; Y.; Hashizume; T.; Kurita-Ochiai; T. and Yamamoto; M.
    International Association for Dental Research, Mar. 2011, Not invited
  • Porphromonas gingivalis ehhancec monocytes adhesion to endothelial cells.
    Hashizume; T.; Kurita-Ochiai; T.; Yamamoto; M.
    International Association for Dental Research, Mar. 2011, Not invited
  • Aggregatibacter actinomycetemcomitans accelerates atherosclerosis with oxidization of low-density lipoprotein
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • Nasal vaccination with a fusion protein of hemagglutinin A antigenic region and maltose binding protein induces immunity via toll-like receptor 4
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • Increased atherosclerotic lesions and Th17 in mice infected with Porphyromonas gingivalis
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • Streptococcus sobrinusの菌体外酵素GTF-Iの経鼻免疫による齲蝕ワクチンの検討
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • Porphyromonas gingivalis感染に動脈硬化マウスモデルの確立
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • Porphyromonas gingivalisによる血管内皮細胞および単球におけるケモカインの発現解析
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • 新たな視点から口腔疾患を誘因とする難治性生全身疾患を考える
    歯科基礎医学会・学術大会, Sep. 2010, Not invited
  • Antigen priming for mucosal IgA responses occurs solely in Peyer's patch after oral administration of recombinant Salmonella
    International Congress of Immunology, Aug. 2010, Not invited
  • Nasal vaccination with a fusion protein of hemagglutinin A and maltose-binding protein elicits protective immunity against Porphyromonas gingivalis infection
    International Congress of Immunology, Aug. 2010, Not invited
  • Establishment of P. gingivalis-accelerated atherosclerosis model using normal mice.
    Internal Associaton for Dental Research, Jul. 2010, Not invited
  • Nasal vaccination with glucosyltransferase-I and CpG oligonuclerotides elicits antibody responses
    International Association of Dental Research, Jul. 2010, Not invited
  • Porpyromonas gingivalis induces ER stress-induced apoptosis and autophagy
    International Association of Dental Research, Jul. 2010, Not invited
  • 酪酸によるTh1およびTh2細胞のアポトーシス誘導とサイトカイン産生抑制
    日本細菌学会総会, Mar. 2010, Not invited
  • 経粘膜投与型ワクチンのための効果的な抗原デリバリーシステムの開発
    山本正文、橋爪智美、落合智子
    先端バイオフォーラム, Feb. 2010, Not invited
  • Induction of apoptosis and autophagy in periodontal pathogen sensitized vascular endothelial cells
    Kurita-Ochiai T; Koizumi Y; Hashizume T; Yamamoto M.
    European Congress of Immunology, Sep. 2009, Not invited
  • Streptococcus sobrinusの菌体外酵素GTF-Iの経鼻免疫による齲蝕ワクチンの検討
    渡邊桂太、橋爪智美、落合智子、秋元芳明、山本正文
    歯科基礎医学会・学術総会, Sep. 2009, Not invited
  • Porphyromonas gingivais感染が血管内皮細胞/単球系細胞共培養に及ぼす影響
    橋爪智美、落合智子、山本正文
    歯科基礎医学会・学術総会, Sep. 2009, Not invited
  • Intravenous immunization with Actinobacillus actinomycetemcomitans accelerates early atherosclerosis
    張寿、橋爪智美、落合智子、山本正文
    歯科基礎医学会・学術総会, Sep. 2009, Not invited
  • Oral immunization with outer membrane protein of Porphyromonas gingivalis and CpG oligodeoxynuclerotides decreases P. gingivalis-induced atheromatous lesions.
    劉辰路、橋爪智美、落合智子、山本正文
    歯科基礎医学会・学術総会, Sep. 2009, Not invited
  • Porphyromonas gingivalisの hemagglutinin Aとマンノース結合タンパクの複合タンパク質の舌下免疫による口腔への抗体応答誘導
    湯澤仁、橋爪智美、落合智子、安孫子宣光、山本正文
    歯科基礎医学会・学術総会, Sep. 2009, Not invited
  • Nasal vaccination with a fusion protein of hemagglutinin A and maltose-binding protein elicits CD11c+CD8α+dendritic cells for mucosal immunity.
    杜媛、橋爪智美、落合智子、山本正文
    歯科基礎医学会・学術総会, Sep. 2009, Not invited
  • CD11b+ alpahL+ dendritic cells play crucial roles in the induction of antigen-specific mucosal IgA antibody responses against recombinant Salmonella.
    Hashizume T; Kurita-Ochiai T; Yamamoto M.
    International Congress of Mucosal Immunology, Jul. 2009, Not invited
  • Nasal vaccination induces long-term protective immunity against Porphyromonas gingivalis infection.
    Du Y; Hashizume T; Kurita-Ochiai T; Hayakawa M; Abiko Y; Yamamoto M.
    International Association for Dental Research, Apr. 2009, Not invited
  • 歯周病原菌の産生する短鎖脂肪酸の分析とヒト細胞アポトーシスに及ぼす影響
    山田潔、田中一、落合智子、落合邦康
    日本細菌学会総会, Mar. 2009, Not invited
  • Critical role of Peyer's patch CD11b+ dendritic cellsd for the induction of antigen-specific mucosasl IgA antibody response to recombinant Salmonella
    Hashizume T.; Guo Z.; Uematsu S.; Jang M.; Kurita-Ochiai T.; Akira S.; Miyasaka M.; Kiyono H.; Yamamoto M.
    日本免疫学会, Dec. 2008, Not invited
  • 酪酸誘導T細胞アポトーシスにおけるミトコンドリア及びERストレスの関与
    Kurita-Ochiai T.; Ochiai K.; Yamamoto M.
    日本免疫学会, Dec. 2008, Not invited
  • P. gingivalis外膜タンパク抗原の経皮免疫による防御免疫応答の誘導
    石倉和明、橋爪智美、落合智子、牧村正治、山本正文
    日本ワクチン学会, Nov. 2008, Not invited
  • P. gingivalis外膜タンパク抗原の経皮免疫による抗原特異的抗体応答の誘導
    石倉和明、橋爪智美、落合智子、牧村正治、山本正文
    歯科基礎医学会, Sep. 2008, Not invited
  • 歯周病原細菌タンパク抗原を発現した乳酸菌による特異的抗体応答の誘導
    石倉和明、橋爪智美、落合智子、牧村正治、山本正文
    歯科基礎医学会, Sep. 2008, Not invited
  • 歯周病原菌の産生する短鎖脂肪酸の分析とその細胞に及ぼす影響
    阿部和正、山田潔、田中一、落合智子、落合邦康
    歯科基礎医学会, Sep. 2008, Not invited
  • The efficacy of CpG oligodeoxynucleotides as an adjuvant for the development of oral vacccine against Porphyromonas gingivalis
    劉辰路、橋爪智美、栗田(落合)智子、藤橋浩太郎、山本正文
    歯科基礎医学会, Sep. 2008, Not invited
  • Intravenous infection with oral pathogen accelerates early atherosclerosis in apolipoprotein E-deficient mice
    張寿、橋爪智美、栗田(落合)智子、山本正文
    歯科基礎医学会, Sep. 2008, Not invited
  • 無毒化キメラ分子アジュバントとP. gingivalis外毒タンパクの経鼻ワクチンによる免疫応答の誘導
    桃井文藝、橋爪智美、落合智子、幸義和、清野宏、山本正文
    歯科基礎医学会, Sep. 2008, Not invited
  • 酪酸誘導アポトーシスに対する歯周炎由来線維芽細胞の感受性の違い
    落合智子、山本正文、落合邦康
    歯科基礎医学会, Sep. 2008, Not invited
  • CpG oligodeoxynucleotides adjuvant for mucosal immunity to Porphyromonas gingivalis.
    Liu C.L. Hashizume T; Kurita-Ochiai T; Fujihashi K; Yamamoto M.
    International Association for Dental Research, Jul. 2008, Not invited
  • Sublingal vaccination with outer membrane protein of Porphyromonas gingivalis.
    Zhang T; Hashizume T; Kurita-Ochiai T; Yamamoto M.
    International Association for Dental Research, Jul. 2008, Not invited
  • Differences in susceptibility of gingival fibroblasts to butyric-acid induced apoptosis.
    Kurita-Ochiai T; Suzuki N; Ochiai K; Yamamoto M.
    International Association for Dental Research, Jul. 2008, Not invited
  • 歯周病原細菌の産生する短鎖脂肪酸の作用と全身疾患
    落合邦康、落合(栗田)智子
    日本無菌生物ノートバイオロジー学会, Jan. 2008, Not invited
  • Suppression of inflammatory cytokine production and induction of apoptosis in periodontal pathogen sensitized HUVEC cells
    Koizumi Y.; Kurita-Ochiai T.; Watanabe K.; Yamamoto M.
    日本免疫学会, Nov. 2007, Not invited
  • Effect of short-chain fatty acid on the expression of adhesion molecules in inhibiting butyric acid induced T-cell apoptosis
    落合邦康、藤岡隼、栗田―落合智子
    日本細菌学会関東支部会, Oct. 2007, Not invited
  • Effects of short-chain fatty acid on the expression of adhesion molecules in inhibiting butyric-acid induced T-cell apoptosis
    K. Ochiai; J. Fujioka; K. Abe; T. Kurita-Ochiai
    International Congress of Immunology, Aug. 2007, Not invited
  • Nasal immunization with outer membrane protein of Porphyromonas gingivalis elicits humoral immunity which decrease atherosclerotic plaque accumulation
    Y. Koizumi; T. Kurita-Ochiai; S. Oguchi; M. Yamamoto
    International Congress of Immunology, Aug. 2007, Not invited
  • A role of reactive oxygen species in mitochondria-, TNF-, and endoplasmic reticulum stress-mediated apoptosis induced by butyric acid
    T. Kurita-Ochiai; T. Hashizume; K. Ochiai; M. Yamamoto
    International Congress of Immunology, Aug. 2007, Not invited
  • Nasal immunization with outer membrane protein of Porphyromonas gingivalis plus nontoxic chimeric enterotoxin adjuvant elicite protective immunity against P. gingivalis infection
    F. Momoi; T. Hashizume; T. Kurita-Ochiai; H. Kiyono; M. Yamamoto
    International Congress of Immunology, Aug. 2007, Not invited
  • Importance of organized Peyer's patches for IgA immunity against Salmonella-derived antigen
    T. Hashizume; T. Kurita-Ochiai; M. Yamamoto
    International Congress of Immunology, Aug. 2007, Not invited
  • 歯周病原性細菌Porphyromonas gingivalisの外膜タンパク質を用いた経鼻免疫はP. gingivalis感染が誘因となる動脈硬化を抑制する
    小泉由起子、栗田(落合)智子、大口純人、山本正文
    日本動脈硬化学会, Jul. 2007, Not invited
  • Pyyer's patches are required for induction of intestinal IgA responses against Salmonella-derived antigen
    T. Hashizume; T. Kurita-Ochiai; M. Yamamoto
    International Congress of Mucosal Immunology, Jul. 2007, Not invited
  • Effects of short-chain fatty acid on cell-cell communication in inhibiting butyric acid induced T cell apoptosis
    K. Ochiai; J. Fujioka; K. Abe; T. Kurita-Ochiai
    International Congress of Mucosal Immunology, Jul. 2007, Not invited
  • Specific antibodies induced by nasal immunization with outer membrane protein of Porphyromonas gingivalis decrease atherosclerotic plaque accumulation
    Y. Koizumi; T. Kurita-Ochiai; S. Oguchi; M. Yamamoto
    International Congress of Mucosal Immunology, Jul. 2007, Not invited
  • A nontoxic chimeric enterotoxin adjuvant for oral immunity to outer membrane protein of Porphyromonas gingivalis
    F. Momoi; T. Hashizume; T. Kurita-Ochiai; H. Kiyono; M. Yamamoto
    International Congress of Mucosal Immunology, Jul. 2007, Not invited
  • 酪酸誘導T細胞アポトーシス解除機構における短鎖脂肪酸のCD44発現に及ぼす影響
    落合邦康、藤岡隼、阿部和正、落合智子
    日本消化器免疫学会, Jul. 2007, Not invited
  • T細胞アポトーシス解除機構における短鎖脂肪酸のT細胞のCD44発現に及ぼす影響
    藤岡隼、阿部和正、栗田(落合)智子、落合邦康
    日本細菌学会, Mar. 2007, Not invited
  • Lymphostructure of Peyer's patch is important for induction of intestinal IgA immunity against recombinant Salmonella
    Hashizume T.; Kurita-Ochiai T.; Yamamoto M.
    日本免疫学会, 2007, Not invited
  • CpG oligodeoxynucleotide is an effective oral adjuvant for the induction of mucosal immunity against 40-kDa outer membrane protein of Porphyromonas gingivalis
    Chen L.; Hashizume T.; Kurita-Ochiai T.; Fujihashi K.; Yamamoto M.
    日本免疫学会, 2007, Not invited
  • Recombinant modified vaccinia virus Ankara (MVA) expressing multivalent tuberculosis antigens along with IL-15 induces specific IFN-g responses in the lung following nasal immunization
    Momoi F.; Hashizume T.; Kurita-Ochiai T.; Kiyono H.; Perera LP. Yamamoto M
    日本ワクチン学会, 2007, Not invited
  • 歯周病細菌タンパク抗原を発現する乳酸菌による特異的抗体応答の誘導
    田中宏征、橋爪智美、安孫子宜光、瀬脇智満、野崎周英、深津晶、牧村正治、落合智子、山本正文
    日本ワクチン学会, 2007, Not invited
  • A nontoxic adjuvant for oral immunity to outer membrane protein of Porphyromonas gingivalis
    MOMOI Fumiki; HASHIZUME Tomomi; OCHIAI Tomoko; KIYONO Hiroshi; YAMAMOTO Masafumi
    日本免疫学会, Dec. 2006, Not invited
  • Periodontoal pathogen accelerates atherosclerosis in spontaneously hyperlipidemic mice
    KOIZUMI Yukiko; KURITA(OCHIAI) Tomoko; ZHANG Tao; OGUCHI Sumito; YAMAMOTO Masafumi
    日本免疫学会, Dec. 2006, Not invited
  • 酪酸がT細胞CD44発現に及ぼす影響
    藤岡隼、阿部和正、落合智子、落合邦康
    Hindgut Club JAPANシンポジウム, Dec. 2006, Not invited
  • Effects of adhesion molecules in cell to cll communication that inhibit butyric acid-induced T-cell apoptosis
    藤岡隼、栗田(落合)智子、阿部和正、落合邦康
    歯科基礎医学会, Sep. 2006, Not invited
  • 歯周病原菌代謝産物・短鎖脂肪酸の粘膜・免疫組織に及ぼす影響
    落合邦康、栗田(落合)智子
    歯科基礎医学会, Sep. 2006, Not invited
  • ヒト口腔由来Lactobacillusからの抗菌物質生産菌の探索
    塩川敏哉、川原綾夏、栗田(落合)智子、小泉由起子、山本正文、平澤正知
    歯科基礎医学会, Sep. 2006, Not invited
  • Importance of adhesion molecules in inhibiting butyric acid induced T-cell apoptosis
    K. OCHIAI; S. SETO; T. KURITA-OCHIAI
    International Association of Dental Research, Jun. 2006, Not invited
  • 酪酸誘導T細胞アポトーシス解除における短鎖脂肪酸の接着分子発現に及ぼす影響
    落合邦康、阿部和正、落合智子
    日本歯周病学会, Apr. 2006, Not invited
  • 酪酸誘導T細胞アポトーシス回避機構における接着分子および細胞外マトリックス発現の解析
    落合邦康、瀬戸真太郎、阿部和正、栗田智子
    日本細菌学会, Mar. 2006, Not invited
  • Role of reactive oxygen species in bacterial infection
    Kurita (Ochiai) Tomoko; Hashizume Tomomi; Ochiai Kuniyasu; and Yamamoto Masafumi
    the Japanese Society for Immunology, Dec. 2005, Not invited
  • Pathogenicity of short chain fatty acid produced by periodontopathic bacteria
    Kuniyasu Ochiai; and Tomoko Kurita-Ochiai
    Japanese Association for Dental Research, Nov. 2005, Not invited
  • ラットにおけるPorphyromonas ginfivalis外膜タンパク質を用いた経皮免疫による免疫応答の誘導
    小泉由紀子、早川光央、栗田(落合)智子、安孫子宣光、大竹繁雄、平澤正知、山本正文
    歯科基礎医学会, Sep. 2005, Not invited
  • 粘膜上皮・線維芽細胞による酪酸誘導T細胞アポトーシス解除機構の解析(1)短鎖脂肪酸の粘膜上皮に及ぼす影響
    阿部和正、栗田(落合)智子、落合邦康
    歯科基礎医学会, Sep. 2005, Not invited
  • Short-chain fatty acid, metabolic by-product of periodontopathic bacteria induces apoptosis in gingival fibroblasts isolated from patients with adult periodontitis
    K. Ochiai; N. Suzuki; K. Otsuka and T. Kurita-Ochiai
    World Congress on Inflammation, Aug. 2005, Not invited
  • Role of reactive oxygen species in butyric acid-induced T cell apoptosis
    T. Kurita-Ochiai; T. Hashizume; K. Ochiai and M. Yamamoto
    World Congress on Inflammation, Aug. 2005, Not invited
  • Fibroblasts rescue butyric acid-induced T-cell apoptosis at the inflammatory sites of anaerobic-bacterial infection in mucous membrane
    K. Ochiai; T. Kurita-Ochiai
    International Symposium on Gnotobiology, Jun. 2005, Not invited
  • 口腔フローラと病巣感染:歯周疾患における短鎖脂肪酸の為害作用と全身疾患
    落合邦康、栗田(落合)智子
    腸内細菌学会, May 2005, Not invited
  • 歯周病原性細菌の産生するヒトIL-1b様物質の精製と分子生物学的解析
    橋爪智美、栗田(落合)智子
    日本細菌学会, Apr. 2005, Not invited
  • 歯周病における酪酸の為害作用とT細胞アポトーシス誘導機序
    栗田(落合)智子
    日本細菌学会, Apr. 2005, Not invited
  • Characterization of effects of butyric acid on cell proliferation, cell cycle distribution, and apoptosis
    Kurita-Ochiai T. and Ochiai K.
    日本免疫学会, Dec. 2004, Not invited
  • Fibroblasts rescue butyric acid-induced T-cell apoptosis; role of adhesion molecules
    K. Ochiai; N. Suzuki; K. Otsuka and T. Kurita-Ochiai
    Japanese Association for Dental Research, Nov. 2004, Not invited
  • Effect of SCFA on mucous membrane and immunoresponse; Butyric acid-induced T-cell apoptosis is down regulated by fibroblasts through the interaction with the adhesion molecules.
    K. Ochiai; S. Seto and T. Kurita-Ochiai
    Science and Research Symposium, Nov. 2004, Not invited
  • Human fibroblasts rescue butytic acid-induced T-cell apoptosis; Role of adhesion molecues
    S. Seto; T. Kurita-Ochiai; K. Abe; K. Ochiai
    Vahouny - ILSI Japan, Sep. 2004, Not invited
  • Cellular mechanism of T-cell apoptosis induced by butyric acid
    T. Kurita-Ochiai; S. Amano; K. Abe and K. Ochiai
    Vahouny-ILSI Japan, Sep. 2004, Not invited
  • 歯垢中のS. sobrinus GTF-1を直接定量できるサンドイッチELISA系の構築
    橋爪智美、米澤英雄、篠崎紀子、栗田(落合)智子、早川光央、小堀樹一郎、牛沢幸司、福島和雄
    歯科基礎医学会, Sep. 2004, Not invited
  • S. mutans GTF-Bの局在性および総産生量についての解析
    米澤英雄、橋爪智美、落合智子、福島和雄
    歯科基礎医学会, Sep. 2004, Not invited
  • 炎症性サイトカインの歯周病原性細菌増殖促進作用
    栗田(落合)智子、落合邦康、福島和雄
    歯科基礎医学会, Sep. 2004, Not invited
  • Cell to cell communication is prerequisite for T cell survival
    T. Kurita-Ochiai; K. Ochiai and K. Fukushima
    International Congress of Immunology, Jul. 2004, Not invited
  • Celllular mechanism involved in butyric acid-induced T cell apoptosis
    K. Ochiai; S. Amano; K. Fukushima and T. Kurita-Ochiai
    International Congress of Immunology, Jul. 2004, Not invited
  • 嫌気性菌代謝産物・酪酸誘導T細胞アポトーシス回避機構における接着分子の役割
    落合邦康、阿部和正、福島和雄、栗田智子
    日本細菌学会, Apr. 2004, Not invited
  • Cell to cell communication is prerequisite for T cell survival
    T. Kurita; K.Ochiai; and K. Fukushima
    日本免疫学会, Dec. 2003, Not invited
  • 歯周病病変部分離歯肉繊維芽細胞の脂肪酸誘導アポトーシスとその機序
    落合邦康、阿部和正、鈴木直人、大塚吉兵衛、栗田智子
    Hindgut Club Japan, Dec. 2003, Not invited
  • Susceptibility of gingival fibroblasts ot apoptosis induced by butyric acid
    K.Ochiai; N.Suzuki; K.Fukushima; and T.Kurita
    Japanese Association of Dental Research, Dec. 2003, Not invited
  • 嫌気性菌代謝産物短鎖脂肪酸の組織為害作用:病変部分分離繊維芽細胞の短鎖脂肪酸によるアポトーシス誘導性
    落合邦康、福島和雄、栗田智子
    日本細菌学会関東支部会, Oct. 2003, Not invited
  • 歯肉繊維芽細胞の脂肪酸誘導アポトーシス感受性とその機序
    落合邦康、鈴木直人、大塚吉兵衛、福島和雄、栗田智子
    日本歯周病学会, Oct. 2003, Not invited
  • 酪酸誘導T細胞アポトーシスにおける細胞内メカニズムの解析
    栗田智子、福島和雄、落合邦康
    日本歯周病学会, Oct. 2003, Not invited
  • 歯肉繊維芽細胞による酪酸誘導T細胞アポトーシス解除機能
    落合邦康、福島和雄、栗田智子
    歯科基礎医学会, Sep. 2003, Not invited
  • サントイッチELISA系を用いた歯垢・唾液中のGTF-B量の定量とS. mutans菌数レベル及びDMFTとの相関について
    橋爪智美、篠崎紀子、栗田智子、小堀樹一郎、牛澤幸司、福島和雄
    歯科基礎医学会, Sep. 2003, Not invited
  • 歯周病原菌代謝産物によるT細胞の細胞周期調節機構
    栗田智子、落合邦康、吉尾雅子、福島和雄
    歯科基礎医学会, Sep. 2003, Not invited
  • バイオフィルム形成及び非形成過程におけるS.mutansGTF-Bの産生性と局在性
    熱田互、橋爪智美、岡田珠美、落合智子、小堀樹一郎、牛澤幸司、池見宅司、福島和雄
    歯科基礎医学会, Sep. 2003, Not invited
  • 嫌気性菌代謝産物・脂肪酸の為害作用:繊維芽細胞のアポトーシス誘導性
    落合邦康、栗田智子
    日本消化器学会, Aug. 2003, Not invited
  • 嫌気性菌代謝産物・脂肪酸の為害作用:T細胞アポトーシス誘導機構の解析
    栗田智子、落合邦康、福島和雄
    日本消化器免疫学会, Aug. 2003, Not invited
  • 嫌気生菌代謝産物・酪酸によるT細胞アポトーシスとその解除機構の解析
    落合邦康、天野滋、福島和雄、栗田智子
    日本細菌学会, Apr. 2003, Not invited

Affiliated academic society

  • Sep. 2013 - Present
    American Society of Microbiology
  • Jul. 2011 - Present
    日本食品免疫学会
  • Apr. 2007 - Present
    日本ワクチン学会
  • 日本細菌学会
  • 日本免疫学会
  • 歯科基礎医学会
  • International Association for Dental Reserch
  • International Congress of Immunology
  • International Congress of Mucosal Immunology
  • 日本歯周病学会

Research Request Themes

  • Effect of oral bacteria on gut immunity
  • Development of the periodontal vaccine for systemic disease control, commisioned research

Research Themes

  • 高齢者における歯肉溝経由ワクチン接種法の開発とその応用
    Apr. 2016 - Mar. 2019
  • 歯周炎で誘導されるインフラマソーム活性化が動脈硬化に及ぼす影響とその制御
    Apr. 2014 - Mar. 2017
    落合智子
  • 歯周炎で誘導される炎症の慢性化機構解明と免疫学的制御機構の開発
    Jun. 2014 - Mar. 2015
    大口純人
  • 学長特別研究 高齢化社会におけるインフルエンザ感染および重症化対策の総合的研究
    日本大学, 学長特別研究, Apr. 2012 - Mar. 2015
  • 口腔感染と誘因とする難治性全身疾患発症機序の解明と疫学調査拠点形成
    Apr. 2010 - Mar. 2015
    落合邦康

Industrial Property Rights

  • 11787, 口腔内疾患予防剤
    落合智子、小林良喜