KIKUIRI Takashi
Researcher Information
Research activity information
Paper
- Synaptic function of descending projections from the insular cortex to the nucleus solitary tract in the rat
Ami Wakabayashi; Yuka Nakaya; Kiyofumi Yamamoto; Yumi Tsutsumi; Fumihiko Sato; Atsushi Yoshida; Takashi Kikuiri; Masayuki Kobayashi
Brain Research, Jan. 2026 - The N-terminal domain of precursor IL-1α enhances IL-6 expression via an intracrine mechanism in oral squamous cell carcinoma
Hiroki Tamura; Mariko Tsunoda; Saya Imaoka; Kaoru Hirayama; Yosuke Yamazaki; Masatake Asano; Takashi Kikuiri
Molecular Biology Reports, Oct. 2025 - Hypoxia enhances osteoclastogenesis in periodontal ligament cells via expression of VEGF and RANKL
Kenchi Hase; Misa Ishiyama; Shoko Ozawa; Yoshitaka Yoshimura; Takashi Kikuiri
Pediatric Dental Journal, Apr. 2025 - Changes in the surface texture of pre-polymerized acrylic resin pediatric crowns following acidulated phosphate fluoride application
Keiya NANRI; Hiroyasu KOIZUMI; Haruto HIRABA; Takashi KIKUIRI; Takayuki YONEYAMA
Dental Materials Journal, Sep. 2024 - Maxillary Central Incisor Eruption Failure Due to Supernumerary Teeth and Pericoronal Hamartoma: A Report of a Rare Case
Misa Ishiyama; Shunsuke Namaki; Hiroki Tamura; Shoko Ozawa; Takashi Kikuiri
Cureus, Jul. 2024 - A Radicular Cyst in the Mandibular Anterior Region of Primary Teeth
Misa Ishiyama; Shunsuke Namaki; Masako Yaoita; Takashi Kikuiri
Cureus, Jul. 2024 - Impaction of Mandibular First Molar by Tooth-Like Hard Tissue
Misa Ishiyama; Shunsuke Namaki; Hiroki Tamura; Kenchi Hase; Takashi Kikuiri
Cureus, Apr. 2024 - Involvement of oxidative stress in orofacial mechanical pain hypersensitivity following neonatal maternal separation in rats
Chihiro Soma; Suzuro Hitomi; Eri Oshima; Yoshinori Hayashi; Kumi Soma; Ikuko Shibuta; Yoshiyuki Tsuboi; Tetsuo Shirakawa; Takashi Kikuiri; Koichi Iwata; Masamichi Shinoda
Scientific Reports, Dec. 2023 - Alteration of monoaminergic systems in the caudal medulla and its possible link to diurnal increase of apnea in a mouse model of Rett syndrome
Manami Hoshi; Misa Ishiyama; Takashi Wada; Kenchi Hase; Masayuki Itoh; Takashi Kikuiri; Tetsuo Shirakawa
Journal of Oral Science, 2023 - A rare case of multiple brain abscesses caused by apical periodontitis of deciduous teeth in congenital heart disease: a case report.
Shizuka Takahashi; Hisato Segoe; Takashi Kikuiri; Yuji Maruo; Tomonobu Sato; Yutaka Watanabe; Zhao Jimei; Yoshitaka Yoshimura; Misa Ishiyama; Atsuhito Takeda; Yasutaka Yawaka; Tetsuo Shirakawa
BMC oral health, Jun. 2022, Refereed, Not invited - Anti-RANKL Inhibits Thymic Function and Causes DRONJ in Mice
Yusuke Nakamura; Takashi Kikuiri; Takahiro Sugiyama; Ayako Maeda; Daisuke Izumiyama; Daigo Yahata; Yoshitaka Yoshimura; Tetsuo Shirakawa; Yoshimasa Kitagawa
International Journal of Dentistry, Apr. 2022 - Bone resorption improvement by conditioned medium of stem cells from human exfoliated deciduous teeth in ovariectomized mice
Ayako Maeda; Takashi Kikuiri; Yoshitaka Yoshimura; Yasutaka Yawaka; Tetsuo Shirakawa
Experimental and Therapeutic Medicine, Feb. 2022 - Occurrence of subcutaneous emphysema during a caries filling procedure: A case report
Takashi Kikuiri; Kureha Saito; Airi Iida; Yoshitaka Yoshimura; Yasutaka Yawaka; Tetsuo Shirakawa
Pediatric Dental Journal, 2022, Refereed, Not invited - Patients with SATB2-associated syndrome exhibiting multiple odontomas.
Kikuiri T; Mishima H; Imura H; Suzuki S; Matsuzawa Y; Nakamura T; Fukumoto S; Yoshimura Y; Watanabe S; Kinoshita A; Yamada T; Shindoh M; Sugita Y; Maeda H; Yawaka Y; Mikoya T; Natsume N; Yoshiura KI
Am J Med Genet A., Dec. 2018, Refereed, Not invited - How much medium do you use for cell culture? Medium volume influences mineralization and osteoclastogenesis in vitro
Yoshitaka Yoshimura; Takashi Kikuiri; Tomokazu Hasegawa; Mino Matsuno; Hajime Minamikawa; Yoshiaki Deyama; Kuniaki Suzuki
MOLECULAR MEDICINE REPORTS, Jul. 2017, Refereed, Not invited - Release from optimal compressive force suppresses osteoclast differentiation
Masaaki Ikeda; Yoshitaka Yoshimura; Takashi Kikuiri; Mino Matsuno; Tomokazu Hasegawa; Kumu Fukushima; Takako Hayakawa; Hajime Minamikawa; Kuniaki Suzuki; Junichiro Iida
MOLECULAR MEDICINE REPORTS, Nov. 2016, Refereed, Not invited - Optimal compressive force accelerates osteoclastogenesis in RAW264.7 cells
Takako Hayakawa; Yoshitaka Yoshimura; Takashi Kikuiri; Mino Matsuno; Tomokazu Hasegawa; Kumu Fukushima; Kenjiro Shibata; Yoshiaki Deyama; Kuniaki Suzuki; Junichiro Iida
MOLECULAR MEDICINE REPORTS, Oct. 2015, Refereed, Not invited - Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration
Yi Liu; Ruili Yang; Xibao Liu; Yu Zhou; Cunye Qu; Takashi Kikuiri; Songlin Wang; Ebrahim Zandi; Junbao Du; Indu S. Ambudkar; Songtao Shi
CELL STEM CELL, Jul. 2014, Refereed, Not invited - Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells.
Kameyama S; Yoshimura Y; Kameyama T; Kikuiri T; Matsuno M; Deyama Y; Suzuki K; Iida J
Int J Mol Med., Feb. 2013, Refereed, Not invited - Effects of bisphosphonates on osteoclastogenesis in RAW264.7 cells
Keigo Abe; Yoshitaka Yoshimura; Yoshiaki Deyama; Takashi Kikuiri; Tomokazu Hasegawa; Kanchu Tei; Hisashi Shinoda; Kuniaki Suzuki; Yoshimasa Kitagawa
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Jun. 2012, Refereed, Not invited - Stage-dependent suppression of the formation of dentin-resorbing multinuclear cells with migration inhibitory factor in vitro
Takashi Kikuiri; Yoshitaka Yoshimura; Futoshi Tabata; Tomokazu Hasegawa; Jun Nishihira; Tetsuo Shirakawa
EXPERIMENTAL AND THERAPEUTIC MEDICINE, Jan. 2012, Refereed, Not invited - Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells
Mayumi Nomura; Yoshitaka Yoshimura; Takashi Kikuiri; Tomokazu Hasegawa; Yumi Taniguchi; Yoshiaki Deyama; Ken-ichi Koshiro; Hidehiko Sano; Kuniaki Suzuki; Nobuo Inoue
JOURNAL OF PHARMACOLOGICAL SCIENCES, Dec. 2011, Refereed, Not invited - Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha
Yi Liu; Lei Wang; Takashi Kikuiri; Kentaro Akiyama; Chider Chen; Xingtian Xu; Ruili Yang; WanJun Chen; Songlin Wang; Songtao Shi
NATURE MEDICINE, Dec. 2011, Refereed, Not invited - Effect of the release from mechanical stress on osteoclastogenesis in RAW264.7 cells
Kenjiro Shibata; Yoshitaka Yoshimura; Takashi Kikuiri; Tomokazu Hasegawa; Yumi Taniguchi; Yoshiaki Deyama; Kuniaki Suzuki; Junichiro Iida
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Jul. 2011, Refereed, Not invited - Cell-Based Immunotherapy With Mesenchymal Stem Cells Cures Bisphosphonate-Related Osteonecrosis of the Jaw-like Disease in Mice
Takashi Kikuiri; Insoo Kim; Takyoshi Yamaza; Kentaro Akiyama; Qunzhou Zhang; Yunsheng Li; Chider Chen; WanJun Chen; Songlin Wang; Anh D. Le; Songtao Shi
JOURNAL OF BONE AND MINERAL RESEARCH, Jul. 2010, Refereed, Not invited - Bisphosphonates Cause Osteonecrosis of the Jaw-Like Disease in Mice
Yanming Bi; Yamei Gao; Driss Ehirchiou; Chunzhang Cao; Takashi Kikuiri; Anh Le; Songtao Shi; Li Zhang
AMERICAN JOURNAL OF PATHOLOGY, Jul. 2010, Refereed, Not invited - SHED repair critical-size calvarial defects in mice
B. M. Seo; W. Sonoyama; T. Yamaza; C. Coppe; T. Kikuiri; K. Akiyama; J. S. Lee; S. Shi
ORAL DISEASES, Jul. 2008, Refereed, Not invited - Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells
Michiko Yamada; Ryuichi Tatsumi; Takashi Kikuiri; Shinpei Okamoto; Shinsuke Nonoshita; Wataru Mizunoya; Yoshihide Ikeuchi; Hiroaki Shimokawa; Kenji Sunagawa; Ronald E. Allen
MUSCLE & NERVE, Sep. 2006, Refereed, Not invited - Immobilization induces acute nitric oxide production in the rat hypothalamus: A role of ionotropic glutamate receptors in the paraventricular nucleus
T Shirakawa; M Mitome; T Kikuiri; W Nakamura; S Oshima; T Hasegawa; M Shindoh; H Oguchi
ENDOCRINOLOGY, Aug. 2004, Refereed, Not invited - Analysis of the Fluctuation of Pulpal Blood Flow in Luxated Permanent Incisors Measured by a Laser Doppler Flowmeter
SHIRAKAWA Tetsuo; KIKUIRI Takashi; TOKI Shima; ABE Michiko; HIGUCHI Kasane; OGUCHI Haruhisa
The Japanese Journal of Pediatric Dentistry, 2004, Not refereed, Not invited - Hydrostatic pressure stimulates the fusion process in Osteoclasts
Yoshitaka Yoshimura; Takashi Kikuiri; Yoshiaki Deyama; Tomokazu Hasegawa; Mitsutoki Hatta; Kuniaki Suzuki
Dentistry in Japan, 2004, Refereed, Not invited - 破骨細胞分化に対するマクロファージ遊走阻止因子（MIF）の影響について−マウス骨髄細胞ならびに骨芽細胞の共存培養条件下におけるMIFの作用
田畑太; 菊入崇; 吉村善隆; 吉田英史; 白川哲夫; 小口春久
小児歯誌, 2003, Refereed, Not invited - Expression of receptor activator of NF-kappa B ligand and osteoprotegerin in culture of human periodontal ligament cells
T Hasegawa; Y Yoshimura; T Kikuiri; Y Yawaka; S Takeyama; A Matsumoto; H Oguchi; T Shirakawa
JOURNAL OF PERIODONTAL RESEARCH, Dec. 2002, Refereed, Not invited - Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-kappa B ligand by osteoblasts
Y Deyama; T Kikuiri; G Ohnishi; YG Feng; S Takeyama; M Hatta; Y Yoshimura; K Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2002, Refereed, Not invited - Human periodontal ligament cells derived from deciduous teeth induce osteoclastogenesis in vitro
T Hasegawa; T Kikuiri; S Takeyama; Y Yoshimura; M Mitome; H Oguchi; T Shirakawa
TISSUE & CELL, Feb. 2002, Refereed, Not invited - Low calcium environment effects osteoprotegerin ligand/osteoclast differentiation factor
S Takeyama; Y Yoshimura; Y Shirai; Y Deyama; T Hasegawa; Y Yawaka; T Kikuiri; A Matsumoto; H Fukuda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2000, Refereed, Not invited - Cyclic tension force activates nitric oxide production in cultured human periodontal ligament cells
T Kikuiri; T Hasegawa; Y Yoshimura; T Shirakawa; H Oguchi
JOURNAL OF PERIODONTOLOGY, Apr. 2000, Refereed, Not invited - Proximal Caries of the First Molars followed by Second Primary Molars which had fallen out
KAGA Masayuki; KUDO Masaki; KIDA Miyuki; HASHIMOTO MASANORI; KIKUIRI Takashi; OGUCHI Haruhisa
The Japanese Journal of Pediatric Dentistry, 2000, Refereed, Not invited - Effect of extracellular calcium concentrations on osteoclast differentiation in vitro
Yoichi Shirai; Yoshitaka Yoshimura; Yasutaka Yawaka; Tomokazu Hasegawa; Takashi Kikuiri; Sadaaki Takeyama; Akira Matsumoto; Haruhisa Oguchi
Biochemical and Biophysical Research Communications, Nov. 1999, Refereed, Not invited - Effect of extracellular calcium concentrations on osteoclast differentiation in vitro
Y Shirai; Y Yoshimura; Y Yawaka; T Hasegawa; T Kikuiri; S Takeyama; A Matsumoto; H Oguchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1999, Refereed, Not invited - Cultured Human Periodontal Ligament Cells Produce Nitric Oxide Through the Interleukin-1 β-independent mechanism
KIKUIRI Takashi; SHIRAKAWA Tetsuo; HASEGAWA Tomokazu; YOSHIMURA Yoshitaka; TAKEYAMA Sadaaki; KAGA Masayuki; OGUCHI Haruhisa
小児歯誌, 1999, Refereed, Not invited - コンポジットレジンの細胞毒性－
小児歯誌, 1998, Refereed, Not invited - 北海道における心身障害児の歯科医療に関する実態調査－一般歯科診療所を対象として－
障歯誌, 1998, Refereed, Not invited - 象牙質接着性レジンシステムから溶出するモノマーと細胞毒性の関係象牙細管を介した細胞毒性試験法－ヒト歯髄由来線維芽細胞に対する
歯材器, 1998, Refereed, Not invited - Salivary catecholamine assay for assessing anxiety in pediatric dental patients.
Mitome M; Shirakawa T; Kikuiri T; Oguchi H
J Clin Pediatr Dent, Apr. 1997, Refereed, Not invited
MISC
- REGENERATING BONE TISSUE USING A COMBINATION OF BONE MARROW MESENCHYMAL STEM CELLS AND HEMATOPOIETIC STEM CELLS
M. Matsuno; T. Kikuiri; Y. Yoshimura; Y. Deyama; K. Suzuki; J. Iida
WOUND REPAIR AND REGENERATION, Jan. 2014, Not refereed, Not invited - SHED repair critical-size calvarial defects in mice (vol 14, pg 428, 2008)
B. M. Seo; W. Sonoyama; T. Yamaza; C. Coppe; T. Kikuiri; K. Akiyama; J. S. Lee; S. Shi
ORAL DISEASES, May 2009, Not refereed, Not invited - Macrophage migration inhibitory factor inhibits formation of mature osteoclasts
Y Yoshimura; T Kikuiri; F Tabata; E Yoshida; Y Deyama; M Hatta; T Shirakawa; K Suzuki
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not refereed, Not invited - Induction of vascular endothelial growth factor in human periodontal ligament cells by mechanical forces in vitro.
T Kikuiri; T Shirakawa; T Hasegawa; Y Yoshimura; F Tabata; H Oguchi
JOURNAL OF DENTAL RESEARCH, Mar. 2002, Not refereed, Not invited - Nitric oxide production in cultured human periodontal ligaments cells
T Kikuiri; T Shirakawa; T Hasegawa; H Oguchi
JOURNAL OF DENTAL RESEARCH, 2000, Not refereed, Not invited - Expression of OPG/OCIF and OPGL/ODF mRNA in human tooth cells.
T Hasegawa; T Kikuiri; Y Yoshimura; Y Shirai; S Takeyama; T Shirakawa; H Oguchi
JOURNAL OF DENTAL RESEARCH, 2000, Not refereed, Not invited - SPECTRAL-ANALYSIS OF LOW-FREQUENCY FLUCTUATIONS IN HUMAN PULPAL BLOOD-FLOW
T SHIRAKAWA; M MITOME; M NOZAKI; T KIKUIRI; S WADA; H OGUCHI
JOURNAL OF DENTAL RESEARCH, 1995, Not refereed, Not invited
Books and other publications
Courses
Research Themes
- 幹細胞のニッチに注目した顎骨再建法の開発
日本学術振興会, 科学研究費補助金 基盤研究（C), Apr. 2014 - Mar. 2017
鄭 漢忠 - 乳歯歯髄由来間葉系幹細胞の骨芽細胞分化機転の解明
日本学術振興会, 科学研究費補助金 基盤研究（C), Apr. 2014 - Mar. 2017
菊入 崇 - アセチルサリチル酸によるBRONJ発症の予防法の開発
日本学術振興会, 科学研究費補助金 基盤研究（C), Apr. 2013 - Mar. 2016
吉村 善隆 - 免疫担当細胞を標的とした新たなＢＲＯＮＪ治療法の開発
日本学術振興会, 科学研究費補助金 基盤研究（C), Apr. 2011 - Mar. 2014
鄭 漢忠 - 性質の異なる破骨細胞に着目した病的・非生理的歯根吸収機構の解明
日本学術振興会, 科学研究費補助金 基盤研究（C), Apr. 2010 - Mar. 2013
吉村 善隆 - Analysis of multiple odontoma in the patients
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2012 - 2012
KIKUIRI Takashi; YOSHIMURA Yoshitaka; FUKUMOTO Satoshi; NAKAMURA Takashi - The research for the niche factor of stem cells in culture condition
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2009 - 2011
KIKUIRI Takashi; YOSHIMURA Yoshitaka - Analysis of the tooth eruption viaregulation of transcription factor
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 2007 - 2008
Takashi KIKUIRI; Shohei OSHIMA; Yoshitaka YOSHIMURA - Studies on stem cell from human exfoliated deciduous teeth
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)), 2006 - 2008
Masato MITOME; 菊入 崇; Tetsuo SHIRAKAWA; Wataru NAKAMURA; Takashi KIKUIRI - 乳歯歯髓細胞が神経幹細胞の増殖・分化に与える影響について
文部科学省, 科学研究費補助金(萌芽研究), 2006 - 2007
三留 雅人; 菊入 崇; 白川 哲夫 - RNAi-induced change in the expression of estrogen receptor α in the median preoptic nuclei of mother rats and its effects on the behavior of their offsprings.
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)), 2005 - 2007
Haruhisa OGUCHI; 長谷川 智一; 中村 渉; 白川 哲夫; 三留 雅人; 菊入 崇; 長谷川 智一 - The analysis of the network transcription regulation by the IKK・r in the tooth differentiation and development.
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 2005 - 2006
Takashi KIKUIRI; 長谷川 智一; 吉村 善隆 - 内因性アンチセンスRNAによる転写因子活性制御と歯胚分化抑制のメカニズム
文部科学省, 科学研究費補助金(萌芽研究), 2004 - 2005
白川 哲夫; 三留 雅人; 菊入 崇 - フッ素徐放性修復材料の溶出成分が歯髄細胞の生存シグナルに及ぼす影響
文部科学省, 科学研究費補助金(若手研究(B)), 2003 - 2004
菊入 崇 - Identification of a novel mutation in the amelogenesis-related genes in Japanese families affected with amelogenesis imperfecta and an approach toward gene therapy
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)), 2002 - 2003
Haruhisa OGUCHI; 三留 雅人; 白川 哲夫; 有賀 正; 菊入 崇 - The identification of genes associated with the root resorption of deciduous tooth and molecular biology analysis of control mechanism.
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 2002 - 2003
長谷川 智一; masato MITOME; 菊入 崇; 吉村 善隆 - 培養歯根膜細胞における血管内皮細胞増殖因子の誘導とそのメカニズム
文部科学省, 科学研究費補助金(奨励研究(A), 若手研究(B)), 2001 - 2002
菊入 崇 - A search for the mechanism of the stretch-induced activation of human periodontal ligament cells
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)), 2000 - 2002
Tetsuo SHIRAKAWA; 土岐 志麻; 菊入 崇; 長谷川 智一; 土岐 志麻 - Analysis of genetic risk factors in periodontal diseses ― Effect of cellular aging on damage of cells ―
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)), 2000 - 2001
Tomokazu HASEGAWA; 菊入 崇; 斎藤 彰; 白川 哲夫; 福本 敏 - Proliferation of neural stem cells in trigeminal nucleus.
Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), 2000 - 2001
土岐 志麻; Masato MITIME; 菊入 崇; 白川 哲夫 - 培養歯根膜細胞の活性と 機械的応力負荷培の関係について 歯胚の再生
