Life sciences, Clinical pharmacy, General physiology

Life sciences, Physiology, General physiology

Synaptic function of descending projections from the insular cortex to the nucleus solitary tract in the rat
Ami Wakabayashi; Yuka Nakaya; Kiyofumi Yamamoto; Yumi Tsutsumi; Fumihiko Sato; Atsushi Yoshida; Takashi Kikuiri; Masayuki Kobayashi
Brain Research, Jan. 2026

Neuronal subtype-dependent kinetics of EPSCs induced by thalamocortical projections from the ventroposteromedial thalamic nucleus to the insular cortex in rats
Yuko Koyanagi; Kiyofumi Yamamoto; Kouhei Kitano; Mie Kajiwara; Masayuki Kobayashi
Pflügers Archiv - European Journal of Physiology, Mar. 2025

Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex
Kiyofumi Yamamoto; Qi-Yu Chen; Zhaoxiang Zhou; Masayuki Kobayashi; Min Zhuo
Philosophical Transactions of the Royal Society B: Biological Sciences, Jun. 2024

P2X receptor- and postsynaptic NMDA receptor-mediated long-lasting facilitation of inhibitory synapses in the rat insular cortex.
Kiyofumi Yamamoto; Satoshi Kosukegawa; Masayuki Kobayashi
Neuropharmacology, Mar. 2024

Descending projections from the insular cortex to the trigeminal spinal subnucleus caudalis facilitate excitatory outputs to the parabrachial nucleus in rats.
Yuka Nakaya; Kiyofumi Yamamoto; Masayuki Kobayashi
Pain, Mar. 2023

Differential regulation of medium spiny and cholinergic neurons in the nucleus accumbens core by the insular and medial prefrontal cortices in the rat.
Hirose K; Nakaya Y; Kitano K; Saito Y; Kaneko R; Yanagawa Y; Yamamoto K; Shirakawa T; Kobayashi M
Pflügers Archiv, Dec. 2021, Refereed, Not invited

Synchronous inhibitory synaptic inputs to layer II/III pyramidal neurons in the murine barrel cortex2021
Brain Research, Oct. 2021, Refereed

Presynaptic NK1 receptor activation by substance P suppresses EPSCs via nitric oxide synthesis in the rat insular cortex
Matsumura S; Yamamoto K; Nakaya Y; O'Hashi K; Kaneko K; Takei H; Tsuda H; Shirakawa T; Kobayashi M
Neuroscience, Oct. 2020, Refereed, Not invited
Corresponding

Gap junction with MLO-A5 osteoblast-like cell line induces ALP and BSP transcription of 3T3-L1 pre-adipocyte like cell line via Hspb1 while retaining adipogenic differentiation ability.
Daisuke Omagari; Manabu Hayatsu; Kiyofumi Yamamoto; Masayuki Kobayashi; Naruchika Tsukano; Masaaki Nameta; Yoshikazu Mikami
Bone, Aug. 2020, Refereed, Not invited

Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex.
Murayama S; Yamamoto K; Fujita S; Takei H; Inui T; Ogiso B; Kobayashi M
Neuropharmacology, May 2019, Refereed, Not invited

Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study.
Satoshi Fujita; Manabu Zama; Keisuke Kaneko; Shota Murayama; Saori Ohtani; Midori Usui; Daichi Noma; Hiromasa Tsuda; Kiyofumi Yamamoto; Masayuki Kobayashi
Neuroscience letters, Mar. 2019

Trigeminal nerve transection-induced neuroplastic changes in the somatosensory and insular cortices in a rat ectopic pain model.
Fujita S†; Yamamoto K†; Kobayashi M (†These authors have contributed equally to this work.)
eNeuro, 2019, Refereed, Not invited

Opposite Roles in Short-Term Plasticity for N-Type and P/Q-Type Voltage-Dependent Calcium Channels in GABAergic Neuronal Connections in the Rat Cerebral Cortex.
Kiyofumi Yamamoto; Masayuki Kobayashi
The Journal of neuroscience : the official journal of the Society for Neuroscience, Nov. 2018

上顎神経障害性疼痛抑制効果に対するミノサイクリン投与法の検討
篠田 雅路; 小林 真之; 藤田 智史; 山本 清文; 久保 亜抄子; 坐間 学; 臼井 緑; 岩田 幸一
PAIN RESEARCH, Jun. 2018, Refereed, Not invited

Ablation of C-fibers decreases quantal size of GABAergic synaptic transmission in the insular cortex.
Shota Murayama; Kiyofumi Yamamoto; Mari Kaneko; Bunnai Ogiso; Masayuki Kobayashi
Neuroscience, Dec. 2017

Histamine H3 heteroreceptors suppress glutamatergic and GABAergic synaptic transmission in the rat insular cortex
H Takei; K Yamamoto; YC Bae; T Shirakawa; M Kobayashi
Front. Neural Circuits, Nov. 2017, Refereed, Not invited

OPIOID SUBTYPE- AND CELL-TYPE-DEPENDENT REGULATION OF INHIBITORY SYNAPTIC TRANSMISSION IN THE RAT INSULAR CORTEX
Eiko Yokota; Yuko Koyanagi; Kiyofumi Yamamoto; Yoshiyuki Oi; Noriaki Koshikawa; Masayuki Kobayashi
NEUROSCIENCE, Dec. 2016, Refereed, Not invited

Osteogenic gene transcription is regulated via gap junction-mediated cell-cell communication.
Yoshikazu Mikami; Kiyofumi Yamamoto; Yuko Akiyama; Masayuki Kobayashi; Eri Watanabe; Nobukazu Watanabe; Masatake Asano; Noriyoshi Shimizu; Kazuo Komiyama
Stem cells and development, Jan. 2015

Osteocytes up-regulate the terminal differentiation of pre-osteoblasts via gap junctions.
Yoichi Nishikawa; Yuko Akiyama; Kiyofumi Yamamoto; Masayuki Kobayashi; Eri Watanabe; Nobukazu Watanabe; Noriyoshi Shimizu; Yoshikazu Mikami; Kazuo Komiyama
Biochemical and biophysical research communications, Jan. 2015

PRESYNAPTIC CELL TYPE-DEPENDENT REGULATION OF GABAERGIC SYNAPTIC TRANSMISSION BY NITRIC OXIDE IN RAT INSULAR CORTEX
K. Yamamoto; H. Takei; Y. Koyanagi; N. Koshikawa; M. Kobayashi
NEUROSCIENCE, Jan. 2015, Refereed, Not invited

Fast-spiking cell to pyramidal cell connections are the most sensitive to propofol-induced facilitation of GABAergic currents in rat insular cortex
Yuko Koyanagi; Yoshiyuki Oi; Kiyofumi Yamamoto; Noriaki Koshikawa; Masayuki Kobayashi
Anesthesiology, 2014, Not refereed, Not invited

Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography
Masayuki Kobayashi; Yilong Cui; Takeo Sako; Tetsuya Sasabe; Naoko Mizoguchi; Kiyofumi Yamamoto; Yasuhiro Wada; Yosky Kataoka; Noriaki Koshikawa
JOURNAL OF NEUROSCIENCE RESEARCH, Oct. 2013, Refereed, Not invited

Cholinergic interneurons suppress action potential initiation of medium spiny neurons in rat nucleus accumbens shell
K. Ebihara; K. Yamamoto; K. Ueda; N. Koshikawa; M. Kobayashi
Neuroscience, Apr. 2013, Not refereed, Not invited

Reciprocal regulation of inhibitory synaptic transmission by nicotinic and muscarinic receptors in rat nucleus accumbens shell.
Yamamoto K; Ebihara K; Koshikawa N; Kobayashi M.
J Physiol., 2013, Refereed, Not invited

Kinetics of GABA(B) autoreceptor-mediated suppression of GABA release in rat insular cortex
Masayuki Kobayashi; Hiroki Takei; Kiyofumi Yamamoto; Hiroshige Hatanaka; Noriaki Koshikawa
JOURNAL OF NEUROPHYSIOLOGY, Mar. 2012, Refereed, Not invited

Presynaptic Interneuron Subtype- and Age-Dependent Modulation of GABAergic Synaptic Transmission by beta-Adrenoceptors in Rat Insular Cortex
Yuko Koyanagi; Kiyofumi Yamamoto; Yoshiyuki Oi; Noriaki Koshikawa; Masayuki Kobayashi
JOURNAL OF NEUROPHYSIOLOGY, May 2010, Refereed, Not invited

Distinct target cell-dependent forms of short-term plasticity of the central visceral afferent synapses of the rat.
Yamamoto K; Noguchi J; Yamada C; Watabe AM; Kato F.
BMC Neuroscience, 2010, Refereed, Not invited
Lead

Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex.
Yamamoto K; Koyanagi Y; Koshikawa N; Kobayashi M.
J. Neurophysiol., 2010, Refereed, Not invited
Lead

Effects of the Ih blockers CsCl and ZD7288 on inherited epilepsy in Mongolian gerbils.
Yoshiki Matsuda; Nobuko Saito; Kiyofumi Yamamoto; Takashi Niitsu; Shinichi Kogure
Experimental animals, Jul. 2008

★Opposite roles in short-term plasticity for N-type and P/Q-type voltage-dependent calcium channels in GABAergic neuronal connections in the rat cerebral cortex.
Yamamoto K and Kobayashi M
J Neurosci, 2018, Refereed, Not invited
Lead

上顎神経障害性疼痛抑制効果に対するミノサイクリン投与法の検討
篠田 雅路; 小林 真之; 藤田 智史; 山本 清文; 久保 亜抄子; 坐間 学; 臼井 緑; 岩田 幸一
PAIN RESEARCH, Jun. 2018, Not refereed, Not invited

Target-cell dependent synaptic modulation of inhibitory synapses by nitric oxide in rat insular cortex
Kiyofumi Yamamoto; Noriaki Koshikawa; Masayuki Kobayashi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not refereed, Not invited

Presynaptic interneuron subtype-dependent modulation of synaptic transmission by beta-adrenoceptors in rat cerebral cortex
Yuko Koyanagi; Kiyofumi Yamamoto; Yoshiyuki Oi; Noriaki Koshikawa; Masayuki Kobayashi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not refereed, Not invited

beta-Adrenoceptors differentially modulate inhibitory synaptic transmission depending on presynaptic interneuron subtype
Masayuki Kobayashi; Yuko Koyanagi; Kiyofumi Yamamoto; Noriaki Koshikawa
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited

Short-term plasticity defines postsynaptic excitation pattern in the solitary complex neurons of the rat
Kiyofumi Yamamoto; Taiko Imura; Jun Noguchi; Fusao Kato
NEUROSCIENCE RESEARCH, 2007, Not refereed, Not invited

Target-dependent extracellular Ca-dependence of the short-term plasticity of the solitary complex synapses in the rat
Kiyofumi Yamamoto
NEUROSCIENCE RESEARCH, 2006, Not refereed, Not invited

P/Q- and N-type voltage-dependent calcium channels determine short-term plasticity of GABAergic synapses in the rat insular cortex.
山本清文; 小林真之
第62回 歯科基礎医学会学術大会, Sep. 2020, Not invited

カイニン酸受容体ー一酸化窒素」経路で誘発する島皮質シナプス長期可塑性
山本清文,小林真之,Min Zhuo
142回薬理学会関東部会, Jun. 2020, Not invited

Novel synaptic pathway originated from the olfactory bulb suppresses the excitation of pyramidal neurons in the insular cortex
Yamamoto K.
2nd Pain and Emotions Summer Meeting., Aug. 2018, Not invited

interneurons receive excitatory inputs from the piriform cortex.The agranular insular cortical fast-spiking
山本清文; 小林真之
第59回歯科基礎医学学会学術大会, Aug. 2017, Not invited

N- and P/Q- type calcium channels differentially regulate short-term plasticity in rat cortical inhibitory synapses.
Yamamoto K; Kobayashi M.
第40回日本神経科学学会, Jul. 2017, Not invited

N- and P/Q- type calcium channels determine short-term plasticity of the GABAergic synapses in the rat insular cortex
山本清文; 小林真之
第90回日本薬理学会, Mar. 2017, Not invited

光遺伝学的手法による島皮質から三叉神経脊髄路尾側亜核への投射経路の機能解明.
中谷有香; 山本清文; 小林真之
第95回日本生理学会, Mar. 2017, Not invited

無顆粒皮質GABA作動性fast-spikingニューロンにおける梨状皮質由来の興奮性入力応答.
山本清文; 越川憲明; 小林真之
第89回日本薬理学会, Mar. 2016, Not invited

Laser scanning photostimulation法を用いた島領野無顆粒皮質の局所回路の同定.
第130回日本薬理学会関東部会
山本清文, 越川憲明, 小林真之, Jul. 2015, Not invited

ラット下歯槽神経切断モデルで生じる島皮質局所神経回路の変性機序の解明.
第132回日本薬理学会関東部会
山本清文, 中村紘子, 越川憲明, 小林真之, May 2015, Not invited

Functional mapping of excitatory synaptic inputs in the agranular insular cortex.
K. Yamamoto; N. Koshikawa; M. Kobayashi
Neuroscience 2013, SfN's 43th annual meeting, Nov. 2013, Not invited

ラット側坐核内抑制性局所神経回路におよぼすコリン作動性修飾
山本清文; 鰕原賀子; 越川憲明; 小林真之
第36回日本神経科学大会, Jul. 2013, Not invited

ATP受容体による島皮質グリア細胞-抑制性シナプス増強で生じる抗疼痛-不安作用の解明
日本学術振興会, 科学研究費助成事業, Apr. 2023 - Mar. 2026
山本 清文

Regulatroy mechanisms of hyperexcitation of insulocortical circuit of the model with neuropathic pain by chemical genetics
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2022 - 31 Mar. 2025
小林 真之; 藤田 智史; 山本 清文; 中谷 有香; 加藤 成樹

The study using chemical genetics to reveal regulation mechanisms of insulocortical hyperactivities in the neuropathic pain model
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2022 - 31 Mar. 2025
小林 真之; 藤田 智史; 山本 清文; 中谷 有香; 加藤 成樹

味覚の臨界期を探るためのGRINレンズによる覚醒マウスの脳内イメージング法の確立
日本学術振興会, 科学研究費助成事業, 01 Apr. 2020 - 31 Mar. 2023
武井 浩樹; 藤田 智史; 山本 清文; 中谷 有香

Mechanisms of insulocortical inhibitory synaptic transmission plasticity that regulates neuropathic pain
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2019 - 31 Mar. 2022
KOBAYASHI Masayuki

Trigeminal nerve transection-induced neuroplastic changes in the somatosensory and insular cortices in a rat ectopic pain model
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2016 - 31 Mar. 2019
KOBAYASHI Masayuki

高頻度発火型GABAニューロンを中継する梨状－島皮質間の新規性局所神経回路の同定
2017 - 2018

Mechanisms of anorectic hormone-induced gustatory regulation in the cerebral cortex
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2013 - 31 Mar. 2016
KOBAYASHI Masayuki; CUI Yelong; INUI Tadashi; MIZOGUCHI Naoko; YAMAMOTO Kiyofumi

オプトジェネティクス法を駆使した島皮質における除痛促進神経回路の解明
2013 - 2014

脳皮質味覚野の局所回路におけるシナプス伝達に対する一酸化窒素の作用機序
2011 - 2012

LSPS法を用いた大脳皮質味覚野における微小カラム状神経回路の解明