Neurofibrillary tangels

Neurodegenerative disease

dementia

model mouse

線虫

タウ

神経細胞死

アルツハイマー病

C. elegans

tau

neuronal cell death

Alzheimer's disease

Life sciences, Neuroscience - general, microtubules and microtubule-associated proteins

Life sciences, Neuropathology, Alzheimer's disease tau

Life sciences, Neuroanatomy and physiology

Apr. 2023 - Present
Nihon University, Graduate School of Pharmacy, Professor

Apr. 2023 - Present
Nihon University, School of Pharmacy, Professor

2001
Hokkaido University, 医学研究科, 病理学専攻

2001
Hokkaido University, Graduate School, Division of Medicine

1997
Hokkaido University, 薬学研究科, 薬学専攻

1997
Hokkaido University, Graduate School, Division of Pharmaceutical Sciences

1995
Nihon University, School of Pharmacy, Department of Biopharmacy

1995
Nihon University, Faculty of Pharmaceutical Science

★Airway inflammation in a novel mouse model of asthma-COPD overlap induced by co-exposure to papain and tobacco smoke.
Genki Kimura; Ai Tagami; Rina Fukui; Masaki Yaita; Tomohiro Miyasaka
Biochemical and biophysical research communications, May 2024, Refereed
Corresponding

★Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
Ayaka Hagita-Tatsumoto; Tomohiro Miyasaka
Journal of Visualized Experiments, Nov. 2023, Refereed

★Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model.
Tetsuya Hori; Kohgaku Eguchi; Han-Ying Wang; Tomohiro Miyasaka; Laurent Guillaud; Zacharie Taoufiq; Satyajit Mahapatra; Hiroshi Yamada; Kohji Takei; Tomoyuki Takahashi
eLife, Apr. 2022, Refereed

★Quantitative fractionation of tissue microtubules with distinct biochemical properties reflecting their stability and lability.
Ayaka Hagita; Satoko Wada-Kakuda; Mika Nobuhara; Nobuto Kakuda; Tomohiro Miyasaka
Biochemical and biophysical research communications, May 2021, Refereed
Corresponding

★Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies.
Hitomi Fujiwara; Shoji Watanabe; Minori Iwata; Shouyou Ueda; Mika Nobuhara; Satoko Wada-Kakuda; Hiroaki Misonou; Tomohiro Miyasaka
Biochemical and biophysical research communications, Jan. 2020, Refereed, Not invited
Corresponding

★Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain.
Atsuko Kubo; Shouyou Ueda; Ayaka Yamane; Satoko Wada-Kakuda; Mai Narita; Makoto Matsuyama; Akane Nomori; Akihiko Takashima; Taisuke Kato; Osamu Onodera; Motohito Goto; Mamoru Ito; Takami Tomiyama; Hiroshi Mori; Shigeo Murayama; Yasuo Ihara; Hiroaki Misonou; Tomohiro Miyasaka
The Journal of neuroscience : the official journal of the Society for Neuroscience, Aug. 2019, Refereed, Not invited

★Regulatory mechanisms for the axonal localization of tau protein in neurons.
Iwata M; Watanabe S; Yamane A; Miyasaka T; Misonou H
Molecular biology of the cell, Aug. 2019, Refereed, Not invited

★Distribution of endogenous normal tau in the mouse brain
Atsuko Kubo; Hiroaki Misonou; Makoto Matsuyama; Akane Nomori; Satoko Wada‐Kakuda; Akihiko Takashima; Mitsuhiro Kawata; Shigeo Murayama; Yasuo Ihara; Tomohiro Miyasaka
Journal of Comparative Neurology, Apr. 2019, Refereed, Not invited

★Imbalanced expression of tau and tubulin induces neuronal dysfunction in C. elegans models of tauopathy
Tomohiro Miyasaka; Yuki Shinzaki; Satomi Yoshimura; Sawako Yoshina; Eriko Kage-Nakadai; Shohei Mitani; Yasuo Ihara
Frontiers in Neuroscience, Jun. 2018, Refereed, Not invited

★The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of Dementia
Ce Xie; Tomohiro Miyasaka
FRONTIERS IN MOLECULAR NEUROSCIENCE, Dec. 2016, Refereed, Not invited
Corresponding

★Curcumin improves tau-induced neuronal dysfunction of nematodes
Tomohiro Miyasaka; Ce Xie; Satomi Yoshimura; Yuki Shinzaki; Sawako Yoshina; Eriko Kage-Nakadai; Shohei Mitani; Yasuo Ihara
NEUROBIOLOGY OF AGING, Mar. 2016, Refereed, Not invited
Lead

★Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups
Yoshiyuki Soeda; Misato Yoshikawa; Osborne F. X. Almeida; Akio Sumioka; Sumihiro Maeda; Hiroyuki Osada; Yasumitsu Kondoh; Akiko Saito; Tomohiro Miyasaka; Tetsuya Kimura; Masaaki Suzuki; Hiroko Koyama; Yuji Yoshiike; Hachiro Sugimoto; Yasuo Ihara; Akihiko Takashima
NATURE COMMUNICATIONS, Dec. 2015, Refereed, Not invited

★Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau
Ce Xie; Yoshiyuki Soeda; Yuki Shinzaki; Yasuko In; Koji Tomoo; Yasuo Ihara; Tomohiro Miyasaka
JOURNAL OF NEUROCHEMISTRY, Oct. 2015, Refereed, Not invited
Corresponding

CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection
Shinichiro Hama; Miho Watanabe-Takahashi; Hiroki Nishimura; Jumpei Omi; Masakazu Tamada; Takashi Saitoh; Katsumi Maenaka; Yuta Okuda; Aoi Ikegami; Asami Kitagawa; Koudai Furuta; Kana Izumi; Eiko Shimizu; Takashi Nishizono; Makoto Fujiwara; Tomohiro Miyasaka; Shigeo Takamori; Hiroshi Takayanagi; Keizo Nishikawa; Toshihiko Kobayashi; Noriko Toyama-Sorimachi; Makoto Yamashita; Toshiya Senda; Takatsugu Hirokawa; Haruhiko Bito; Kiyotaka Nishikawa
mBio, Nov. 2024

Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP.
Haruko Miyazaki; Saki Nishioka; Tomoyuki Yamanaka; Manabu Abe; Yukio Imamura; Tomohiro Miyasaka; Nobuto Kakuda; Toshitaka Oohashi; Tomomi Shimogori; Kazuhiro Yamakawa; Masahito Ikawa; Nobuyuki Nukina
Transgenic research, Jun. 2024, Refereed

MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons
Eiichi Tokuda; Yume Sakashita; Naoya Tokoro; Ayano Date; Yasuhiro Kosuge; Tomohiro Miyasaka
International Journal of Molecular Sciences, May 2024, Refereed

Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation.
Hiroyuki Morino; Takashi Kurashige; Yukiko Matsuda; Maiko Ono; Naruhiko Sahara; Tomohiro Miyasaka; Yoshiyuki Soeda; Hitoshi Shimada; Yu Yamazaki; Tetsuya Takahashi; Yuishin Izumi; Hidefumi Ito; Hirofumi Maruyama; Makoto Higuchi; Koji Arihiro; Tetsuya Suhara; Akihiko Takashima; Hideshi Kawakami
Movement disorders clinical practice, Apr. 2024, Refereed

ADモデルマウスにおける老人斑検出の最適化
角田 伸人; 吉村 陸哉; 宮坂 知宏; 船本 聡; 池川 雅哉; 斎藤 貴志; 西道 隆臣
Dementia Japan, Oct. 2023

Mass spectrometry imaging in Alzheimer's disease.
Masaya Ikegawa; Nobuto Kakuda; Tomohiro Miyasaka; Yumiko Toyama; Takashi Nirasawa; Karolina Minta; Jörg Hanrieder
Brain connectivity, Mar. 2023, Refereed

The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Rikuya Yoshimura; Tomohiro Miyasaka; Satoru Funamoto; Takashi Saito; Takaomi C Saido; Masaya Ikegawa; Nobuto Kakuda
Brain and behavior, Mar. 2023, Refereed

Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes.
Tomohiro Torii; Yuki Miyamoto; Rinaho Nakata; Yuto Higashi; Yohei Shinmyo; Hiroshi Kawasaki; Tomohiro Miyasaka; Hiroaki Misonou
Glia, Dec. 2022, Refereed

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
Tomohiro Torii; Tomohiro Miyasaka; Hiroaki Misonou
Frontiers in Cell and Developmental Biology, Oct. 2022, Refereed

Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission.
Yukio Imamura; Ayami Okuzumi; Saki Yoshinaga; Akiko Hiyama; Yoshiaki Furukawa; Tomohiro Miyasaka; Nobutaka Hattori; Nobuyuki Nukina
Communications biology, Jun. 2022, Refereed

Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis.
Hajime Kato; Hiroyasu Sato; Michiaki Okuda; Jun Wu; Shingo Koyama; Yasuhiko Izumi; Tomonori Waku; Mitsuyoshi Iino; Masashi Aoki; Shigeki Arawaka; Yasuyuki Ohta; Kenichi Ishizawa; Kanan Kawasaki; Yasuomi Urano; Tomohiro Miyasaka; Noriko Noguchi; Toshiaki Kume; Akinori Akaike; Hachiro Sugimoto; Takeo Kato
Amyotrophic lateral sclerosis & frontotemporal degeneration, Dec. 2021, Refereed

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo.
Taro Saito; Tomoki Chiku; Mikiko Oka; Satoko Wada-Kakuda; Mika Nobuhara; Toshiya Oba; Kanako Shinno; Saori Abe; Akiko Asada; Akio Sumioka; Akihiko Takashima; Tomohiro Miyasaka; Kanae Ando
Human molecular genetics, Jun. 2021, Refereed

A potential defense mechanism against amyloid deposition in cerebellum.
Alam Shahnur; Masaki Nakano; Seiko Ishihara; Nobuto Kakuda; Tomohiro Miyasaka; Hina Uchiyama; Yuuna Shirai; Mohammad Moniruzzaman; Takashi Saito; Takaomi C Saido; Masaki Nishimura; Satoru Funamoto
Biochemical and biophysical research communications, Jan. 2021, Refereed

イメージング質量分析法とショットガンプロテオーム解析を用いた脳病理解析
外山 友美子; 朴 洪宣; 梶田 遼; 角田 伸人; 宮坂 知宏; 韮澤 崇; 村山 繁雄; 貫名 信行; 井原 康夫; 池川 雅哉
Dementia Japan, Oct. 2020

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection.
Jumpei Omi; Miho Watanabe-Takahashi; Katsura Igai; Eiko Shimizu; Ching-Yi Tseng; Tomohiro Miyasaka; Tsuyoshi Waku; Shinichiro Hama; Rieka Nakanishi; Yuki Goto; Yuri Nishino; Atsuo Miyazawa; Yasuhiro Natori; Makoto Yamashita; Kiyotaka Nishikawa
Nature communications, Jan. 2020, Refereed, Not invited

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.
Mari Nakamura; Seiji Shiozawa; Daisuke Tsuboi; Mutsuki Amano; Hirotaka Watanabe; Sumihiro Maeda; Taeko Kimura; Sho Yoshimatsu; Fumihiko Kisa; Celeste M Karch; Tomohiro Miyasaka; Akihiko Takashima; Naruhiko Sahara; Shin-Ichi Hisanaga; Takeshi Ikeuchi; Kozo Kaibuchi; Hideyuki Okano
Stem cell reports, Oct. 2019, Refereed, Not invited

Visualization of Amyloid beta Deposits in Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Ikegawa M; Nirasawa T; Kakuda N; Miyasaka T; Kuzuhara Y; Murayama S; Ihara Y
JoVE, Sep. 2018, Refereed, Not invited

Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
Mita Y; Kataoka Y; Saito Y; Kashi T; Hayashi K; Iwasaki A; Imanishi T; Miyasaka T; Noguchi N
Scientific reports, Aug. 2018, Refereed, Not invited

Isoform-independent and-dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development
Dilina Tuerde; Taeko Kimura; Tomohiro Miyasaka; Kotaro Furusawa; Aki Shimozawa; Masato Hasegawa; Kanae Ando; Shin-Ichi Hisanaga
Journal of Biological Chemistry, 2018, Refereed, Not invited

Distinct deposition of amyloid-beta species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry
Nobuto Kakuda; Tomohiro Miyasaka; Noriyuki Iwasaki; Takashi Nirasawa; Satoko Wada-Kakuda; Junko Takahashi-Fujigasaki; Shigeo Murayama; Yasuo Ihara; Masaya Ikegawa
ACTA NEUROPATHOLOGICA COMMUNICATIONS, Oct. 2017, Refereed, Not invited
Lead

タウからの創薬
宮坂知宏
老年期認知症研究会誌(Web), 2016, Refereed, Invited
Corresponding

Role of tau protein in the pathogenesis of dementia
XIE Ce; XIE Ce; 宮坂知宏
基礎老化研究, 2015, Refereed, Not invited
Corresponding

Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
Yoshiro Saito; Tomohiro Miyasaka; Hiroyuki Hatsuta; Kazuko Takahashi-Niki; Kojiro Hayashi; Yuichiro Mita; Osamu Kusano-Arai; Hiroko Iwanari; Hiroyoshi Ariga; Takao Hamakubo; Yasukazu Yoshida; Etsuo Niki; Shigeo Murayama; Yasuo Ihara; Noriko Noguchi
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Jul. 2014, Refereed, Not invited

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles
Ce Xie; Tomohiro Miyasaka; Satomi Yoshimura; Hiroyuki Hatsuta; Sawako Yoshina; Eriko Kage-Nakadai; Shohei Mitani; Shigeo Murayama; Yasuo Ihara
PLOS ONE, Feb. 2014, Refereed, Not invited
Corresponding

tau-Tgマウス脳における内在性および外来性タウの神経細胞内局在
久保厚子; 御園生裕明; 松山誠; 高島明彦; 井原康夫; 井原康夫; 宮坂知宏
Dementia Japan, 2014, Refereed, Not invited

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
Satoru Funamoto; Toru Sasaki; Seiko Ishihara; Mika Nobuhara; Masaki Nakano; Miho Watanabe-Takahashi; Takashi Saito; Nobuto Kakuda; Tomohiro Miyasaka; Kiyotaka Nishikawa; Takaomi C. Saido; Yasuo Ihara
Nature Communications, 2013, Refereed, Not invited

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction
Akira Kobayashi; Takako Tsukide; Tomohiro Miyasaka; Tomoko Morita; Tatsuya Mizoroki; Yoshiro Saito; Yasuo Ihara; Akihiko Takashima; Noriko Noguchi; Akiyoshi Fukamizu; Yosuke Hirotsu; Makiko Ohtsuji; Fumiki Katsuoka; Masayuki Yamamoto
GENES TO CELLS, Jun. 2011, Refereed, Not invited

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals
Yoko Ogawa Akazawa; Yoshiro Saito; Takao Hamakubo; Yoshinori Masuo; Yasukazu Yoshida; Keiko Nishio; Mototada Shichiri; Tomohiro Miyasaka; Hiroko Iwanari; Yasuhiro Mochizuki; Tatsuhiko Kodama; Noriko Noguchi; Etsuo Niki
NEUROSCIENCE LETTERS, Oct. 2010, Refereed, Not invited

Microtubule destruction induces tau liberation and its subsequent phosphorylation
Tomohiro Miyasaka; Sinji Sato; Yoshitaka Tatebayashi; Akihiko Takashima
FEBS LETTERS, Jul. 2010, Refereed, Not invited
Lead

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo
Emmanuel Planel; Pavan Krishnamurthy; Tomohiro Miyasaka; Li Liu; Mathieu Herman; Asok Kumar; Alexis Bretteville; Helen Y. Figueroa; Wai Haung Yu; Robert A. Whittington; Peter Davies; Akihiko Takashima; Ralph A. Nixon; Karen E. Duff
JOURNAL OF NEUROSCIENCE, Nov. 2008, Refereed, Not invited

Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms
Emmanuel Planel; Yoshitaka Tatebayashi; Tomohiro Miyasaka; Li Liu; Lili Wang; Mathieu Herman; W. Haung Yu; Jose A. Luchsinger; Brian Wadzinski; Karen E. Duff; Akihiko Takashima
JOURNAL OF NEUROSCIENCE, Dec. 2007, Refereed, Not invited

Granular tau oligomers as intermediates of tau filaments
Sumihiro Maeda; Naruhiko Sahara; Yuko Saito; Miyuki Murayama; Yuji Yoshiike; Hyonchol Kim; Tomohiro Miyasaka; Shigeo Murayama; Atsushi Ikai; Akihiko Takashima
BIOCHEMISTRY, Mar. 2007, Refereed, Not invited

c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis
Yoshitaka Tatebayashi; Emmanuel Planel; De-Hua Chui; Shinji Sato; Tomohiro Miyasaka; Naruhiko Sahara; Miyuki Murayama; Naomi Kikuchi; Katsuji Yoshioka; Ravid Rivka; Akihiko Takashima
FASEB JOURNAL, Feb. 2006, Refereed, Not invited

Formation of Tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1)
K Tanemura; DH Chui; T Fukuda; M Murayama; JM Park; T Akagi; Y Tatebayashi; T Miyasaka; T Kimura; T Hashikawa; Y Nakano; T Kudo; M Takeda; A Takashima
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2006, Refereed, Not invited

Search for neurodegeneration mechanism in the tauopathy brain.
宮坂知宏
神経化学, 2006, Not refereed, Invited
Lead

Progressive neurodegeneration in C-elegans model of tauopathy
T Miyasaka; Z Ding; K Gengyo-Ando; M Oue; H Yamaguchi; S Mitani; Y Ihara
NEUROBIOLOGY OF DISEASE, Nov. 2005, Refereed, Not invited
Lead

Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads
T Miyasaka; A Watanabe; Y Saito; S Murayama; DMA Mann; M Yamazaki; R Ravid; M Morishima-Kawashima; K Nagashima; Y Ihara
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Aug. 2005, Refereed, Not invited
Lead

Association among tau, NFT formation, neuron loss, and brain function.
宮坂 知宏
Dementia Japan, 2005, Not refereed, Not invited

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: Implications for Alzheimer's disease
E Planel; T Miyasaka; T Launey; DH Chui; K Tanemura; S Sato; O Murayama; K Ishiguro; Y Tatebayashi; A Takashima
JOURNAL OF NEUROSCIENCE, Mar. 2004, Not refereed, Not invited

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
T Miyasaka; Y Tatebayashi; DH Chui; T Akagi; K Mishima; K Iwasaki; A Fujiwara; K Tanemura; A Murayama; K Ishiguro; E Planel; S Sato; T Hashikawa; A Takashima
Molecular Neurobiology of Alzheimer Disease and Related Disorders, 2004, Refereed, Not invited

Deregulation of GSK-3 beta and JNK in a mouse model of tauopathy: A kinase combination that induces Alzheimer-type tau hyperphosphorylation
Y Tatebayashi; S Sato; T Akagi; DH Chui; T Miyasaka; E Planel; M Murayama; A Takashima
Molecular Neurobiology of Alzheimer Disease and Related Disorders, 2004, Refereed, Not invited

Molecular Neurobiology of Alzheimer Disease and Related Disorders.
宮坂 知宏
Karger/Deregulation of GSK-3 and JNK in a Mouse Model of Tauopathy: A Kinase Combination That Induces Alzheimer-Type Tau Hyperphosphorylation., 2004, Not refereed, Not invited

Aberrant tau phosphorylation by glycogen synthase kinase-3 beta and JNK3 induces oligomeric tau fibrils in COS-7 cells
S Sato; Y Tatebayashi; T Akagi; DH Chui; M Murayama; T Miyasaka; E Planel; K Tanemura; XY Sun; T Hashikawa; K Yoshioka; K Ishiguro; A Takashima
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2002, Refereed, Not invited

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
Y Tatebayashi; T Miyasaka; DH Chui; T Akagi; K Mishima; K Iwasaki; M Fujiwara; K Tanemura; M Murayama; K Ishiguro; E Planel; S Sato; T Hashikawa; A Takashima
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2002, Not refereed, Not invited

Posttranslational modifications of microtubule associated protein tau
Tomohiro Miyasaka; Akihiko Takashima
Brain and Nerve, Sep. 2002, Refereed, Not invited

Early-onset, rapidly progressive familial tauopathy with R406W mutation
Y Saito; A Geyer; R Sasaki; S Kuzuhara; E Nanba; T Miyasaka; K Suzuki; S Murayama
NEUROLOGY, Mar. 2002, Refereed, Not invited

Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation.
T Miyasaka; M Morishima-Kawashima; R Ravid; W Kamphorst; K Nagashima; Y Ihara
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Sep. 2001, Not refereed, Not invited

Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation
T Miyasaka; M Morishima-Kawashima; R Ravid; P Heutink; JC van Swieten; K Nagashima; Y Ihara
AMERICAN JOURNAL OF PATHOLOGY, Feb. 2001, Not refereed, Not invited

Inhibition of GABA(A) receptor chloride channel by quinolones and norfloxacin-biphenylacetic acid hybrid compounds
Y Ito; T Miyasaka; H Fukuda; K Akahane; Y Kimura
NEUROPHARMACOLOGY, 1996, Refereed, Not invited

イメージング質量分析法を用いたアルツハイマー病脳の組織マルチオミクス解析
外山友美子; 徳平壮一郎; 朴洪宣; 韮澤崇; 角田伸人; 宮坂知宏; 村山繁雄; 齊藤祐子; 内藤康秀; 貫名信行; 池川雅哉
Dementia Japan, 2021

Considering the abnormality of pathological tau; lessons from physiological tau!
宮坂知宏
月刊細胞, 2021

イメージング質量分析法とショットガンプロテオーム解析を用いた脳病理解析
外山友美子; 朴洪宣; 梶田遼; 角田伸人; 宮坂知宏; 韮澤崇; 村山繁雄; 貫名信行; 井原康夫; 池川雅哉
Dementia Japan, 2020

マウス腎臓における微小管結合タンパク質タウの発現
宮坂知宏; 常嘉瑞; 姚シビ; 角田聡子; 建部陽嗣; 徳田隆彦
Dementia Japan, 2020

In vivoにおけるタウのリン酸化と微小管結合能への影響
萩田彩香; 角田聡子; 延原美香; 角田伸人; 宮坂知宏
Dementia Japan, 2020

Inhibitory effects of 2,4-Bis(cyclic-amino)phenolderivatives on tau aggregation
宮坂知宏; 宮坂知宏; 高見真子; 高見真子; 角田聡子; 井上善一; 延原美香; 藤田有紀; 杉本八郎; 井原康夫
Dementia Japan, 2019

低温負荷による脳内タウの過剰リン酸化に対するドネペジルの作用
高良香葉子; 高鳥悠記; 高島小波; 中西涼介; 泉安彦; 赤池昭紀; 宮坂知宏; 久米利明; 久米利明; 土田勝晴
日本薬学会年会要旨集(CD-ROM), 2019

Imaging Mass Spectrometry to Study Neuropathology of Alzheimer's Disease
池川 雅哉; 角田 伸人; 宮坂 知宏; 韮澤 崇; 村山 繁雄; 井原 康夫
臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌, Sep. 2018, Not refereed, Not invited

イメージング質量分析法を用いたアルツハイマー病および脳アミロイドアンギオパチー脳プロテオーム解析
池川雅哉; 角田伸人; 宮坂知宏; 韮澤崇; 村山繁雄; 井原康夫
日本アミロイドーシス研究会学術集会プログラム・抄録集, 2018

チューブリン変性を起点としたタウ異常性の獲得の可能性
藤原ひとみ; 渡辺祥司; 岩田実里; 上田翔洋; 延原美香; 和田聡子; 御園生裕明; 宮坂知宏
Dementia Japan, 2018

タウ蛋白質の神経細胞における軸索局在化機構と細胞内動態
岩田実里; 渡辺祥司; 宮坂知宏; 御園生裕明
Dementia Japan, 2018

タウisoformの成体神経新生における役割
石垣診祐; 石垣診祐; 岩出展行; 藤岡祐介; 遠藤邦幸; 河合香里; 石橋みなか; 勝野雅央; 渡辺宏久; 宮坂知宏; 祖父江元
臨床ストレス応答学会大会抄録集, 2018

神経細胞におけるタウ蛋白質の分子動態
岩田実里; 渡辺祥司; 宮坂知宏; 御園生裕明
日本生化学会大会(Web), 2018

イメージング質量分析法を用いたアルツハイマー病脳病理研究
池川雅哉; 角田伸人; 宮坂知宏; 韮澤崇; 藤ヶ崎純子; 村山繁雄; 井原康夫
臨床病理, 20 Oct. 2017, Not refereed, Not invited

FTDP-17患者由来iPS細胞を用いたin vitro病態モデルの確立及び表現型解析
中村 真理; 渡部 博貴; 塩澤 誠司; 久永 眞市; 佐原 成彦; 木村 妙子; 宮坂 知宏; 高島 明彦; 池内 健; 岡野 栄之
Dementia Japan, Oct. 2017, Not refereed, Not invited

Phosphorylation and isoform expression of tau are regulated independently during mouse brain development
D. Tuerde; T. Kimura; T. Miyasaka; A. Asada; T. Saito; K. Ando; S. Hisanaga
JOURNAL OF NEUROCHEMISTRY, Aug. 2017, Not refereed, Not invited

心血管疾患病理解析のためのイメージング質量分析法
韮澤崇; 難波寛子; 寺田恵; 工藤寿治; 宮坂知宏; 角田伸人; BRUNEVAL P; 植田初江; 池川雅哉
質量分析総合討論会講演要旨集, 01 May 2017, Not refereed, Not invited

神経細胞におけるタウ蛋白質の動態と軸索局在機構の解明
岩田実里; 渡辺祥司; 宮坂知宏; 朴洪宣; 御園生裕明
日本生化学会大会(Web), 2017

イメージング質量分析法を用いたアルツハイマー病脳タンパク質の解析
池川雅哉; 宮坂知宏; 角田伸人; 岩崎了教; 韮澤崇; 藤ヶ崎純子; 村山繁雄; 井原康夫
Dementia Japan, 15 Oct. 2016, Not refereed, Not invited

神経細胞におけるアルツハイマー病原因蛋白質タウの軸索局在の分子機序
岩田実里; 渡辺祥司; 宮坂知宏; 朴洪宣; 御園生裕明
日本生化学会大会(Web), 2016

脳発生に伴うタウ関連タンパク質の発現変化
宮坂知宏; 上田翔洋; 角田聡子; 久保厚子
Dementia Japan, 2016

神経細胞におけるタウ蛋白質の軸索局在化機構の解明
岩田実里; 渡辺祥司; 宮坂知宏; 朴洪宣; 御園生裕明
Dementia Japan, 2016

Imaging Mass Spectrometry for the Research of Alzheimer's Disease
IKEGAWA Masaya; MIYASAKA Tomohiro; KAKUDA Nobuto; IHARA Yasuo
Journal of the Mass Spectrometry Society of Japan, 2016, Not refereed, Not invited

イメージングマススペクトロメトリーを用いたアルツハイマー病脳の解析
池川雅哉; 宮坂知宏; 角田伸人; 岩崎了教; 韮澤崇; 隅蔵大幸; 村山繁雄; 井原康夫; 井原康夫
Dementia Japan, 15 Sep. 2015, Not refereed, Not invited

アルツハイマー病脳研究のための質量イメージング解析
池川雅哉; 宮坂知宏; 角田伸人; 岩崎了教; 韮澤崇; 隅蔵大幸; 村山繁雄; 井原康夫
JSBMS Letters, 20 Aug. 2015, Not refereed, Not invited

イメージング質量分析を用いたアルツハイマー病脳の解析
池川雅哉; 宮坂知宏; 角田伸人; 岩崎了教; 韮澤崇; 隅蔵大幸; 村山繁雄; 井原康夫
質量分析総合討論会講演要旨集, 08 Jun. 2015, Not refereed, Not invited

表面に固定した天然変性タンパク質分子のダイナミクス計測
志村眞弘; 松下祐福; 一柳光平; 宮坂知宏; 関口博史; 井原康夫; 佐々木裕次
表面科学学術講演会講演要旨集, 06 Nov. 2014, Not refereed, Not invited

構造を持たないタウタンパク質1分子の動的挙動計測
志村眞弘; 松下祐福; 一柳光平; 宮坂知宏; 関口博史; 井原康夫; 佐々木裕次; 佐々木裕次
物構研サイエンスフェスタ要旨集, 2014

正常脳におけるタウの神経細胞内局在
久保厚子; 御園生裕明; 松田響子; 松山誠; 河田光博; 初田裕幸; 村山繁雄; 井原康夫; 井原康夫; 宮坂知宏
Dementia Japan, 2014

MAP2とタウの異なる凝集性を決定するアミノ酸配列の同定
謝策; 新崎有紀; 添田義行; 高島明彦; 井原康夫; 宮坂知宏
Dementia Japan, 2014

X線によるタウタンパク質天然変性領域の1分子ダイナミクス計測
志村眞弘; 松下祐福; 池崎圭吾; 宮坂知宏; 一柳光平; 関口博史; 井原康夫; 佐々木裕次; 佐々木裕次
日本分子生物学会年会プログラム・要旨集(Web), 2014

TDP‐17の原因遺伝子MAPTの新規挿入変異の同定と生化学解析
KAWAKAMI HIDESHI; MORINO TOYOYUKI; MATSUDA YUKIKO; OSAWA RYOSUKE; HIRAKI KEIKO; KURASHIGE TSUYOSHI; IZUMI YUISHIN; YAMASAKI YU; TAKAHASHI TETSUYA; TAKASHIMA AKIHIKO; SOEDA YOSHIYUKI; MIYASAKA TOMOHIRO; HIGUCHI MAKOTO; SAWARA SHIGEHIKO; SUHARA TETSUYA; SHIMADA HITOSHI; ITO HIDEFUMI; MARUYAMA HIROFUMI
日本生物学的精神医学会誌, 2014, Not refereed, Not invited

Phosphorylated tau and microtubule-associated protein 2 induce neuronal toxicity in C. elegans
C. Xie; T. Miyasaka; S. Yoshimura; S. Yoshina; E. Kage-Nakadai; S. Mitani; Y. Ihara
JOURNAL OF NEUROCHEMISTRY, Oct. 2012, Not refereed, Not invited

神経細線維交錯とニューロピル糸剤に新たに蓄積したタウの可視化(Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads)
宮坂 知宏; 渡邊 淳; 斉藤 祐子; 村山 繁雄; デビッド・マン; 山崎 峰雄; リブカ・レィビッド; 森島 真帆; 長嶋 和郎; 井原 康夫
神経化学, Aug. 2005, Not refereed, Not invited

タウオパチーの線虫モデル(C.elegans model of tauopathy)
丁 震; 宮坂 知宏; 安藤 恵子; 三谷 昌平; 井原 康夫
神経化学, Aug. 2004, Not refereed, Not invited

顆粒状凝集物を介したタウ線維形成
前田 純宏; 金 賢徹; 赤木 巧; 宮坂 知宏; 原 正彦; 端川 勉; 猪飼 篤; 高島 明彦
Dementia Japan, Aug. 2004, Not refereed, Not invited

FAD(家族性アルツハイマー病)変異PS-1(presenilin-1)knock-inマウスにおけるtau封入体を持つ神経の変性(Neural degeneration with tau inclusion in FAD mutant PS-1 knock-in mice)
種村 健太郎; 宮坂 知宏; 近藤 隆; 高島 明彦
日本獣医学会学術集会講演要旨集, Aug. 2004, Not refereed, Not invited

Biochemical and immunocytochemical study on FTDP-17 - From patients to mice
T Miyasaka; Y Tatebayashi; M Morishima; A Takashima; Y Ihara
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not refereed, Not invited

タウタンパク質凝集機序の解析
前田 純宏; 金 賢徹; 廣谷 直子; 宮坂 知宏; 楯林 義孝; 猪飼 篤; 高島 明彦
Dementia Japan, Aug. 2003, Not refereed, Not invited

Posttranslational Modifications of Microtubule Associated Protein Tau
宮坂 知宏; 高島 明彦
Brain and nerve : 神経研究の進歩, Sep. 2002

4R v337m Tau-transgenic mice脳内へのAβ 40 Fibrils注入によるTauのリン酸化及びGSK-3betaの役割について
崔 得華; 吉池 裕二; 朴 正美; 村山 美由紀; Planel Emmanuel; 種村 健太郎; 楯林 義孝; 宮坂 知宏; 金 英蘭; 高島 明彦
Dementia Japan, Aug. 2002, Not refereed, Not invited

Molecular basis of FTDP17
A Takashima; DH Chui; Y Tatebayashi; T Kentaro; S Sato; T Miyasaka; E Planel
NEUROBIOLOGY OF AGING, Jul. 2002, Not refereed, Not invited

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
Y Tatebayashi; T Miyasaka; DH Chui; K Tanemura; A Takashima; T Akagi; R Rivid
NEUROBIOLOGY OF AGING, Jul. 2002, Not refereed, Not invited

変異タウ遺伝子導入マウスの解析
種村 健太郎; 宮坂 知宏; 溝呂木 達也; 赤木 巧; 冨永 貴志; 端川 勉; 市川 道教; 高島 明彦
基礎老化研究, Apr. 2002, Not refereed, Not invited

痴呆 基礎から臨床 アルツハイマー病の発症機序タウタンパクからのアプローチ
高島 明彦; 孫 小燕; 楯林 義孝; 種村 健太郎; 村上 明子; 佐藤 慎二; 宮坂 知宏
日本神経精神薬理学雑誌, Dec. 2001, Not refereed, Not invited

R406W変異タウ発現マウスの解析
宮坂 知宏; 楯林 義孝; 種村 健太郎; 赤木 巧; 高島 明彦
Dementia Japan, Aug. 2001, Not refereed, Not invited

JNK(c-Jun N-terminal kinase)によるTauリン酸化
佐藤 慎二; 楯林 義孝; 宮坂 知宏; 種村 健太郎; 高島 明彦
Dementia Japan, 2001, Not refereed, Not invited

Molecular Neurobiology of Alzheimer Disease and Related Disorders.
Karger, 2004, Not refereed

Molecular Neurobiology of Alzheimer Disease and Related Disorders.
Karger, 2004, Not refereed

Molecular Neurobiology of Alzheimer Disease and Related Disorders.
2004, Not refereed

Apr. 2023 - Present

Apr. 2023 - Present

Cell biology
Doshisha University

米国神経科学会

日本認知症学会

日本神経化学会

Society for Neuroscience

Japanese society for dementia

Japanese society for neurochemistry

日本神経病理学会

Optical control of auditory pathway for next generation auditory prosthesis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2024 - 31 Mar. 2028
小林 耕太; 飛龍 志津子; 兎田 幸司; 玉井 湧太; 宮坂 知宏; 古山 貴文

微小管結合タンパク質の機能損失が個体間コミュニケーションに与える影響
日本学術振興会, 科学研究費助成事業, 01 Apr. 2022 - 31 Mar. 2026
宮坂 知宏; 小林 耕太

近赤外レーザーを用いた次世代人工内耳の開発と評価
日本学術振興会, 科学研究費助成事業, 01 Apr. 2021 - 31 Mar. 2025
小林 耕太; 飛龍 志津子; 宮坂 知宏; 古山 貴文; 玉井 湧太

Development of novel therapeutic agents for Alzheimer's disease based on analysis of neuroprotective signals and regulation of tau phosphorylation
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2017 - 31 Mar. 2020
Takada-Takatori Yuki

Mechanism of tau protein aging and neurodegeneration
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 10 Jul. 2014 - 31 Mar. 2019
Takashima Akihiko; Soeda Yoshiyuki; Sumioka Akio; Misonou Hiroaki; Taguchi Akiko

Development of anti-tauopathy drugs using C. elegans.
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2010 - 2011
MIYASAKA Tomohiro

Imbalanced expression of tau and tubulin is an essential step for pathogenesis of tauopathy.
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2008 - 2009
MIYASAKA Tomohiro

線虫モデルを用いたタウオパチー神経変性機構の解明と治療法の探索
日本学術振興会, 科学研究費助成事業, 2006 - 2007
宮坂 知宏

変異型タウ遺伝子導入によるヒト痴呆疾患モデルマウスの作製と解析
日本学術振興会, 科学研究費助成事業, 2005 - 2005
佐藤 隆史; 原田 彰宏; 宮坂 知宏

線虫モデルを用いたタウオパチー神経変性機構の解明
日本学術振興会, 科学研究費助成事業, 2004 - 2005
宮坂 知宏

Mechanism of NFT formation
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2001 - 2004
TAKASHIMA Akihiko; SAHARA Naruhiko; ISHIZUKA Koko; CHUI De-Hua; PLANEL Emmanuel

Hyperphosphorylation and aggregation of tau protein, and neuronal death
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2000 - 2004
IHARA Yasuo; MORISHIMA Maho; FUNAMOTO Satoru; MIYASAKA Tomohiro; ITO Mamoru; FUJITA Shinobu

アルツハイマー病脳における異常タウと神経細胞死の解明
日本学術振興会, 科学研究費助成事業, 2002 - 2003
宮坂 知宏

タウオパチー神経変性メカニズムの解明

Study of the mechanisms of neuronal cell death in tauopathy brains.

特許2962687, Tau aggregation inhibitor
MIYASAKA Tomohiro

特願2018-164623, リン酸化タンパク質の組織学的検出方法及びキット
宮坂 知宏, 東 優人

特許6313750, タウ凝集阻害剤
宮坂知宏, 杉本八郎, 時實梨衣, 大江洋平, 太田哲男, 高島明彦, 添田義行, 井原康夫, 井上善一

特許9907799, Tau aggregation inhibitor
Tomohiro Miyasaka, Hachiro Sugimoto, Rie Tokizane, Yuki Shinzaki, Yohei Oe, Tetsuo Ota, Akihiko Takashima, Yoshiyuki Soeda, Yasuo Ihara, Yoshikazu Inoue

2,4-ジアミノフェノール誘導体、及び、タウ及び／又はアミロイドβの凝集阻害剤

イメージング質量分析の前処理方法

灌流用注射針

2,4-ジアミノフェノール誘導体及びタウ凝集阻害剤

２‐アミノヒドロキノン誘導体及びタウ凝集阻害剤

２‐アミノヒドロキノン誘導体及びタウ凝集阻害剤