Bachelor of Dental Science, Nihon University, Mar. 2003

Doctor of Philosophy in Dental Science, Nihon University, Mar. 2008

non-odontgenic tooth ache

Pulptits

Tooth Pain

Orofacial Pain

Life sciences, Conservative dentistry and endodontics, Preservative Odontological Therapy

Apr. 2018 - Present
Nihon University School of Dentistry, Department of Endodontics, Associate Professor, D.D.S., Ph. D.

Jan. 2010 - Mar. 2018
Nihon University School of Dentistry, Department of Endodontics, Assistant Professor, D.D.S., Ph. D.

Apr. 2008 - Dec. 2010
Nihon University School of Dentistry, Department of Endodontics, Clinical Resident, D.D.S., Ph. D.

Apr. 2003 - Mar. 2008
Nihon University Graduate School of Dentistry, Doctoral Program in Clinical Dentistry

Apr. 1997 - Mar. 2003
Nihon University, School of Dentistry, Dentistry

★Mirogabalin as a Therapeutic Option for Neuropathic Pain Emerging Postendodontic Treatment: An Observational Study
Kohei Shimizu; Takuya Yasukawa; Takuro Izumida; Kana Ozasa; Keita Takizawa; Noboru Noma; Makoto Hayashi; Osamu Takeichi
Journal of Endodontics, Dec. 2024, Refereed
Corresponding

★Mirogabalin as a Therapeutic Option for Neuropathic Pain Emerging Post-endodontic Treatment: A Two-Case Report
Kohei Shimizu; Takuya Yasukawa; Kinuyo Ohara; Noboru Noma; Makoto Hayashi; Osamu Takeichi
Journal of Endodontics, Sep. 2024, Refereed
Corresponding

★Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
Kanno K; Shimizu K; Shinoda M; Hayashi M; Takeichi O; Iwata K
J Neuroinflammation, Oct. 2020, Refereed, Invited
Corresponding

Effects of Autogenic Training on Pain Modulation in Burning Mouth Syndrome: A Preliminary Study
Keita Takizawa; Kana Ozasa; Kohei Shimizu; Noboru Noma
Cureus, Mar. 2025, Refereed

Development of Novel Root Canal Obturation Techniques Using Prototype Obturators in Conjunction With a Resin-Based Hybrid Root SEAL (MetaSEAL) Soft Paste Sealer
Taisuke Shokaku; Kohei Shimizu; Tomomi Arai; Takuya Yasukawa; Makoto Hayashi; Osamu Takeichi
Cureus, Mar. 2025, Refereed
Corresponding

The Potential Link Between Abdominal Migraine and Chronic Apical Periodontitis: A Case Report
Fuu Sakai; Kana Ozasa; Kohei Shimizu; Noboru Noma
Cureus, Jan. 2025, Refereed

Expression of S1008/A9 in Human Periapical Granulomas
TAMURA Takahiro; MIYATA Taiki; HIMI Kazuma; HATORI Keisuke; NAKAMURA Takeshi; SHIMIZU Kouhei; SUZUKI Yusuke; HASUIKE Akira; INOUE Seiya; OKADA Masashi; YABUHARA Yukiko; SUGURO Hisashi; SHOUKAKU Taisuke; YASUKAWA Takuya; HAYASHI Makoto; TAKEICHI Osamu
日本歯科保存学雑誌, Apr. 2022, Refereed

Efficacy of prototype endodontic obturators for novel root canal obturation techniques using a resin-based sealer in various powder-liquid ratios
Akiko Takatsuki-Hira; Masahiro Kaketani; Kohei Shimizu; Takahito Tamura; Takeshi Nakamura; Yurika Toyama; Takayuki Yoneyama; Osamu Takeichi.
Journal of Oral Science, Feb. 2021, Refereed, Not invited

Comparison of Obturation Ratios between the Thermafil Obturator and NT Condenser,,with Obturation Gutta NT using Micro-CT Analysis
Kohei Shimizu; Takuya Yasukawa; Keisuke Hatori; Yusuke Suzuki; Osamu Takeichi; Makoto Hayashi; Hisashi Suguro; Takeshi Nakamura; Takahito Tamura; Hiroshi Kobayashi; Yoriyuki Hirano and Bunnai Ogiso.
THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY, Apr. 2020, Refereed, Invited
Lead

Connexin 43 expression in satellite glial cells contributes to ectopic tooth-pulp pain.
Komiya H; Shimizu K; Ishii K; Kudo H; Okamura T; Kanno K; Shinoda M; Ogiso B; Iwata K
Journal of Oral Science, Dec. 2018, Refereed, Invited
Corresponding

Role of Neuron-Glial Interaction Mediated by IL-1β in Ectopic Tooth Pain
H. Komiya; K. Shimizu; N. Noma; Y. Tsuboi; K. Honda; K. Kanno; K. Ohara; M. Shinoda; B. Ogiso; K. Iwata
Journal of Dental Research, Apr. 2018, Refereed, Not invited

Role of medullary astroglial glutamine synthesis in tooth pulp hypersensitivity associated with frequent masseter muscle contraction.
Watase T; Shimizu K; Ohara K; Komiya H; Kanno K; Hatori K; Noma N; Honda K; Tsuboi Y; Katagiri A; Shinoda M; Ogiso B; Iwata K
Molecular Pain, Mar. 2018, Refereed, Not invited
Corresponding

Involvement of transient receptor potential vanilloid 1 channel expression in orofacial cutaneous hypersensitivity following tooth pulp inflammation
Tetsuro Watase; Kohei Shimizu; Hiroki Komiya; Kinuyo Ohara; Koichi Iwata; Bunnai Ogiso
Journal of Oral Science, 2018, Refereed, Not invited

Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity
Kuniya Honda; Masamichi Shinoda; Masahiro Kondo; Kohei Shimizu; Hisashi Yonemoto; Katsuhiko Otsuki; Ryuta Akasaka; Akihiko Furukawa; Koichi Iwata
PAIN, Sep. 2017, Refereed, Not invited

Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases
Noboru Noma; Kohei Shimizu; Kosuke Watanabe; Andrew Young; Yoshiki Imamura; Junad Khan
QUINTESSENCE INTERNATIONAL, Apr. 2017, Refereed, Not invited

Bactericidal effect of hydroxyl radicals generated by the sonolysis and photolysis of hydrogen peroxide for endodontic applications
Haruna Ibi; Makoto Hayashi; Fumihiko Yoshino; Muneaki Tamura; Ayaka Yoshida; Yoshimi Kobayashi; Kohei Shimizu; Masaichi-Chang-il Lee; Kenichi Imai; Bunnai Ogiso
Microbial pathogenesis, Feb. 2017, Refereed, Not invited

Botulinum neurotoxin type A alleviates mechanical hypersensitivity associated with infraorbital nerve constriction injury in rats.
Noma N; Watanabe K; Sato Y; Imamura Y; Yamamoto Y; Ito R; Maruno M; Shimizu K; Iwata K
Neurosci Lett., Nov. 2016, Refereed, Not invited

Involvement of trigeminal transition zone and laminated subnucleus caudalis in masseter muscle hypersensitivity associated with tooth inflammation.
Shimizu K; Matsumoto K; Noma N; Matsuura S; Ohara K; Komiya H; Watase T; Ogiso B; Tsuboi Y; Shinoda M; Hatori K; Nakaya Y; Iwata K.
PLoS One, Oct. 2014, Refereed, Not invited
Lead

Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation
Kinuyo Ohara; Kohei Shimizu; Shingo Matsuura; Bunnai Ogiso; Daisuke Omagari; Masatake Asano; Yoshiyuki Tsuboi; Masamichi Shinoda; Koichi Iwata
Journal of Neuroinflammation, Nov. 2013, Refereed, Not invited

Mechanisms underlying ectopic persistent tooth-pulp pain following pulpal inflammation.
Matsuura S; Shimizu K; Shinoda M; Ohara K; Ogiso B; Honda K; Katagiri A; Sessle BJ; Urata K; Iwata K.
PLoS One, Jan. 2013, Refereed, Not invited

咀嚼筋群における筋筋膜痛症候群に起因した非歯原性歯痛と歯内疾患を併発した一例.
清水 康平,佐藤 隆夫,羽鳥 啓介,小林 千明,柴崎 郁恵,重森 葉子,加藤 岳詩,橋本 一浩,佐藤 洋子,澤田 朋美,小木曽 文内
日本歯科保存学雑誌, Dec. 2012, Refereed, Not invited
Lead

Hemicrania continua in a patient with concomitant dental disease.
Noma N; Kamo H; Shimizu K; Plaza-Villegas F; Oka S; Imamura Y.
J Am Dent Assoc., Oct. 2012, Refereed, Not invited

A Case report:,Non-odontogenic Toothache assosiated with Endodontic treatment
清水 康平; 小林 千明; 羽鳥 啓介; 加藤 岳詩; 橋本 一浩; 小木會 文内
The journal of Japan Endodontic Association, May 2011, Refereed, Not invited
Lead

Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity
Adachi K; Hu JW; Suzuki I; Sakagami H; Koshikawa N; Sessle BJ; Shinoda M; Miyamoto M; Honda K; Iwata K
Molecular Pain, Sep. 2010, Refereed, Not invited

Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors.
Wei Guo; Hu Wang; Shiping Zou; Stacey C LaGraize; Koichi Iwata; Feng Wei; Ronald Dubner and Ke Ren
Molecular Pain, Dec. 2009, Refereed, Not invited
Lead

Microinjection of IL-1beta into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry.
Shimizu K; Chai B; Lagraize SC; Wei F; Dubner R; Ren K
Open pain Journal, Jan. 2009, Refereed, Not invited
Lead

Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
Wei Guo; Hu Wang; Mineo Watanabe; Kohei Shimizu; Shiping Zou; Stacey C. LaGraize; Feng Wei; Ronald Dubner; Ke Ren
JOURNAL OF NEUROSCIENCE, May 2007, Refereed, Not invited

歯髄のカプサイシン刺激により三叉神経脊髄路核尾側亜核および上部頸髄ニューロンに誘導されるERKリン酸化に対する迷走神経切断の効果
清水 康平,小木曽 文内,伊藤 公一,岩田 幸一
日大歯学, Jan. 2007, Refereed, Not invited
Lead

Phosphorylation of Extracellular Signal-Regulated Kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation.
Asano M; Kitagawa J; Ogiso B; Ren K; Oki H; Matsumoto M; Iwata K
Brain Research, Feb. 2006, Refereed, Not invited
Lead

Effect of chronic inflammation on dorsal horn nociceptive neurons in aged rats
J Kitagawa; K Kanda; M Sugiura; Y Tsuboi; A Ogawa; K Shimizu; N Koyama; H Kamo; T Watanabe; K Ren; K Iwata
JOURNAL OF NEUROPHYSIOLOGY, Jun. 2005, Refereed, Not invited

Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats.
Tsuboi Y; Takeda M; Tanimoto T; Ikeda M; Matsumoto S; Kitagawa J; Teramoto K; Yamazaki Y; Shima A; Ren K; Iwata K
Pain, Oct. 2004, Refereed, Not invited

★1つ上を目指す歯内療法へのアプローチ（Ⅳ）抜髄 Initial Treatment（臨床編Ⅱ）歯内療法における打診痛を考察する
清水康平,羽鳥啓介,大原絹代,篠田雅路,小木曾文内
日本歯科評論, 2016, Refereed, Not invited
Lead

歯内治療後に発症する異常疼痛,とくに神経障害性疼痛への新規治療法の確立
清水 康平; 安川 拓也; 宮田 泰伎; 林 誠; 武市 収
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, Oct. 2023

Involvement of neuron-glial interaction mediated by IL-1in ectopic tooth pain
Hiroki Komiya; Kohei Shimizu; Noboru Noma; Kuniya Honda; Kohei Kanno; Kinuyo Ohara; Masamichi Shinoda; Bunnai Ogiso; Koichi Iwata
J Dental Res, 01 Nov. 2017, Refereed, Not invited

症例から考える歯の痛みの鑑別ポイント
清水 康平, Single work, 責任著者
株式会社ヒョーロンパブリッシャーズ, Apr. 2023

Initial Treatment
Kohei Shimizu, Contributor, 歯内療法における打診痛を考察する, Kohei Shimizu et al.
株式会社 ヒョーロンパブリッシャーズ, Jul. 2016, Not refereed

歯内療法における打診痛を考察する
清水 康平, Joint work, 清水 康平 他
株式会社 ヒョーロン・パブリッシャーズ, 2016, Not refereed

メカニズムから読み解く 痛みの臨床テキスト
Joint work
株式会社 南江堂, Mar. 2015, Not refereed

★歯髄炎に起因する舌痛覚過敏発症に対する三叉神経節内Macrophage TLR4-IL-1RIシグナル伝達系の関与
菅野浩平; 清水康平; 岩田幸一; 篠田雅路
第25回一般社団法人日本口腔顔面痛学会学術大会, Nov. 2020, Not invited

★象牙質知覚過敏から根管治療後歯痛まで、口腔顔面痛的再考
清水康平
第25回一般社団法人日本口腔顔面痛学会学術大会, Nov. 2020, Invited

★歯髄炎による舌痛覚過敏発症に対する三叉神経節内Macrophage の関与
菅野浩平、清水康平、篠田雅路、岩田幸一
第24回一般社団法人日本口腔顔面痛学会学術大会, Sep. 2019, Not invited

★Pulpitis-induced tongue hyperalgesia involving TLR4 signaling in trigeminal ganglion cells
Kohei Kanno; Kohei Shimizu; Kinuyo Ohara; Bunnai Ogiso
第149回度日本歯科保存学会秋季学術大会, Nov. 2018, Not invited

Effect of reactivated Epstein-Barr virus on refractory apical periodontitis
Taiki Miyata; Takahiro Tamura; Keisuke Hatori; Kouhei Shimizu; Makoto Hayashi; Osamu Takeichi
The 156th Meeting of the Japanese Society of Conservative Dentistry June 16-29, 2022, Not invited

Evaluation of novel root canal obturation techniques using prototype endodontic obturators with a resin-based sealer in various powder-to-liquid ratios
Akiko Takatsuki-Hira; Kohei Shimizu; Takuya Yasukawa; Hisashi Suguro; Makoto Hayashi; Osamu Takeichi
日本歯科保存学会 2021年度春季学術大会（第154回）, Not invited

Involvement of TLR4 signaling mediated by macrophage in tongue hyperalgesia
Kohei Kanno; Kohei Shimizu; Bunnai ogiso
第151回度日本歯科保存学会秋季学術大会, Nov. 2019, Not invited

急性歯髄炎により誘導される歯痛錯誤の末梢神経機構
古宮 宏記,清水 康平,大原 絹代,高橋 なつみ,小木曾 文内
第145回度日本歯科保存学会秋季学術大会, Jun. 2017, Not invited

咬筋痛に関与した歯髄痛覚過敏発症の神経機構解明
清水 康平,渡瀬 哲郎,小木曽 文内
第146回度日本歯科保存学会春季学術大会, Jun. 2017, Not invited

無髄神経欠損モデルラットにおける島皮質局所回路の変化
3.村山 翔太, 武市 収, 清水 康平, 小林 真之, 小木曾 文内
第145回度日本歯科保存学会秋季学術大会, Oct. 2016, Not invited

Mechanisms underlying ectopic tooth pulp pain associated with masseter muscle contractinon
渡瀬 哲郎,清水 康平1,篠田 雅路,古宮 宏記,岩田 幸一,小木曾 文内
第21回日本口腔顔面痛学会学術大会, Sep. 2016, Not invited

Mechanisms underlying referred tooth-pulp pain following acute pulpitis
古宮 宏記,清水 康平,渡瀬 哲郎,篠田 雅路,岩田 幸一,小木曾 文内
第21回日本口腔顔面痛学会学術大会, Sep. 2016, Not invited

Mechanisms underlying referred tooth-pulp pain following acute pulpitis
古宮 宏記; 清水 康平; 林 誠; 鶴町 保; 小木曾 文内
日本歯科保存学会 2016 年度春季学術大会（第 144 回）, Jun. 2016, 日本大学歯学部, Not invited

Mechanisms underlying referred tooth-pulp pain following acute pulpitis
平成27年度日本歯科保存学会秋季学術大会（第143回）, Nov. 2015, Not invited

Toll-like receptor 4 in the trigeminal sensory neurons is involved in tongue-referred pain following tooth pulp inflammation
平成26年度日本歯科保存学会秋季学術大会（第141回）, Oct. 2014, Not invited

Mechanisms underlying ectopic persistent tooth-pulp pain following pathological masseter muscle pain
平成26年度日本歯科保存学会秋季学術大会（第141回）, Oct. 2014, Not invited

Toll-like receptor 4 in the trigeminal sensory neurons is involved in tongue-referred pain following tooth pulp inflammation
大原 絹代1); 清水 康平; 武市 収; 鶴町 保1; 會田 泰代; 小木曾 文内
平成25年度日本歯科保存学会春季学術大会（第138回）, Jun. 2013, Not invited

Toll-like receptor 4 signaling in trigeminal ganglion contributes tongue persistent pain following tooth pulp inflammation
Kinuyo Ohara; Masamichi Shinoda and Koichi Iwata
日本神経科学大会, Sep. 2012, Not invited

Toll-like receptor 4 in the trigeminal sensory neurons is involved in tongue-referred pain following tooth pulp inflammation
Kinuyo Ohara; Masamichi Shinoda; Bunnai Ogiso and KoichiIwata
IASP, Aug. 2012, Not invited

CFA誘導性歯髄炎により発症する舌の機械痛覚過敏に対するToll-like Receptor４の関与
大原 絹代; 武市 収; 鶴町 保; 會田 泰代,小木曾 文内
春季歯科保存学, Jun. 2012, Not invited

三叉神経節細胞のToll-like Receptor４は歯髄炎により発症する舌痛覚過敏に関与する
大原 絹代; 岩田 幸一; 小木曾文内
日大歯学, May 2012, 日本大学歯学部, Not invited

Mechanisms underlying ectopic orofacial allodynia and hyperalgesia following periapical periodontitis
Shingo matsuura; Bunnai ogiso and Koichi Iwata
Society for Neuroscience, Nov. 2011, Not invited

Mechanisms underlying ectopic orofacial allodynia and hyperalgesia following periapical periodontitis
Kohei Shimizu and koichi Iwata
Society for Orofacial Pain, Oct. 2011, Not invited

Mechanisms underlying ectopic orofacial allodynia and hyperalgesia following periapical periodontitis
清水 康平; 松浦 慎吾; 大原 絹代; 岩田 桜子; 小木會 文内
平成23年度 春季歯科保存学会, Jun. 2011, Not invited

Mechanisms of extrateritorial hyperexcitability in TRG neurons following tooth pulp inflammation
松浦 慎吾、清水 康平、大原 絹代、原田 集、岩田 幸一、小木曾 文内
第133回日本歯科保存学会, Oct. 2010, Not invited

Mechanisms of extrateritorial hyperexcitability in TRG neurons following tooth pulp inflammation
松浦 慎吾、清水 康平、小木曾 文内、岩田 幸一
第4回三叉神経領域の感覚－運動統合機構研究会, Oct. 2010, Not invited

日本歯科保存学会

Clarification of the mechanism for orofacial pain contributes to the development of new treatment
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2019 - Mar. 2022
SHIMIZU Kohei

Elucidation of the onset mechanism of orofacial pain with the aim of establishing a new treatment for toothache
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2016 - Mar. 2019
SHIMIZU Kohei; SHINODA Masamichi; HONDA Kuniya

Clarification of mechanisms underlying ectopic persistent pain to establish proper diagnosis and treatment assosiated with endodontic disease
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2013 - Mar. 2016
SHIMIZU Kohei; SHINODA Masamichi; HONDA Kuniya

Differential involvement of rostral and caudal Vc neurons in masseter muscle hypersensitivity associated with periodontal inflammation
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2011 - 2012
SHIMIZU Kohei

Mechanisms of orofacial hyperalgesia in periapical periodontitis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2009 - 2010
SHIMIZU Kohei

Elucidation of the onset mechanism of abnormal pain after endodontic treatment and establishment of treatment methods: Simultaneous investigation from basic and clinical research
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2024 - Mar. 2028
Kohei Shimizu