KATAFUCHI Takeshi

Department of MedicineAssociate Professor

Research Keyword

  • biochemistry, molecular biology, endocrinology, pharmacology

Field Of Study

  • Life sciences, Medical biochemistry, Biochemistry, Molecular biology, General medical chemistry

Career

  • Oct. 2018 - Dec. 2019
    University of Texas Southwestern Medical Center, Department of Neuroscience, Instructor
  • Jun. 2008 - Sep. 2018
    University of Texas Southwestern Medical Center, Department of Pharmacology, Instructor
  • Apr. 1996 - May 2008
    National Cardiovascular Center Research Institute

Educational Background

  • 01 Apr. 1993 - 31 Mar. 1996
    Tokyo Institute of Technology, 生命理工学研究科, バイオサイエンス専攻
  • Apr. 1993 - Mar. 1996
    Tokyo Institute of Technology, 生命理工学研究科, バイオサイエンス専攻
  • Apr. 1991 - Mar. 1993
    Tokyo Institute of Technology, 理工学研究科, 科学専攻
  • Apr. 1987 - Mar. 1991
    Tokyo Institute of Technology, 理学部, 生命理学科

Award

  • The Society of Cardiovascular Endocrinology and Metabolism, Young Investigator Award

Paper

  • ★PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice.
    Katafuchi T; Holland WL; Kollipara RK; Kittler R; Mangelsdorf DJ; Kliewer SA.
    Proc Natl Acad Sci U S A., Nov. 2018, Refereed, Not invited
    Lead
  • ★Detection of FGF15 in plasma by stable isotope standards and,capture by anti-peptide antibodies and targeted mass spectrometry.
    Katafuchi T; Esterházy D; Lemoff A; Ding X; Sondhi V; Kliewer SA; Mirzaei H; Mangelsdorf DJ.
    Cell Metabolism, Jun. 2015, Refereed, Not invited
    Lead
  • Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis
    Takeshi Katafuchi; Makoto Makishima
    International Journal of Molecular Science, May 2022, Refereed, Invited
    Lead
  • Hepatic uptake of conjugated bile,acids is mediated by both sodium taurocholate cotransporting polypeptide and,organic anion transporting polypeptides and modulated by intestinal sensing of,plasma bile acid levels in mice.
    Slijepcevic D; Roscam Abbing RLP; Katafuchi T; Blank A; Donkers JM; van Hoppe; S; de Waart DR; Tolenaars D; van der Meer JHM; Wildenberg M; Beuers U; Oude; Elferink RPJ; Schinkel AH; van de Graaf SFJ.
    Hepatology, Sep. 2017, Refereed, Not invited
  • Mutations in Tyr808 reveal a potential auto-inhibitory mechanism of guanylate cyclase-B regulation.
    Katafuchi T.
    Biosci Rep, May 2013, Refereed, Not invited
    Lead
  • The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
    Zhang Y; Xie Y; Berglund ED; Coate KC; He TT; Katafuchi T; Xiao G; Potthoff MJ; Wei W; Wan Y; Yu RT; Evans RM; Kliewer SA; Mangelsdorf DJ.
    eLife, Oct. 2012, Refereed, Not invited
  • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.
    Dutchak PA; Katafuchi T; Bookout AL; Choi JH; Yu RT; Mangelsdorf DJ; Kliewer SA.
    Cell, Feb. 2012, Refereed, Not invited
  • CNP/GC-B system: a new regulator of adipogenesis.
    Katafuchi T; Garbers DL; Albanesi JP.
    Peptides, Jul. 2010, Refereed, Not invited
    Lead
  • Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides
    Katafuchi T; Hamano K; Minamino N
    Biochem Biophys Res Commun, Jan. 2004, Refereed
    Lead
  • Identification of second and third calcitonin receptor-stimulating peptides in porcine brain.
    Katafuchi T; Hamano K; Kikumoto K; Minamino N
    Biochem Biophys Res Commun, Aug. 2003, Refereed, Not invited
  • Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity
    Takeshi Katafuchi; Katsuro Kikumoto; Kazumasa Hamano; Kenji Kangawa; Hisayuki Matsuo; Naoto Minamino
    J Biol Chem, Apr. 2003, Refereed
    Lead
  • Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins.
    Kikumoto K; Katafuchi T; Minamino N.
    Hypertens Res, Feb. 2003, Refereed, Not invited
  • Regulation of adrenomedullin secretion from cultured cells
    Tomoda Y; Isumi Y; Katafuchi T; Minamino N
    Peptides, Nov. 2001, Refereed
  • Enhanced expression and release of C-type natriuretic peptide in freshwater eels
    Takei Y; Inoue K; Ando K; Ihara T; Katafuchi T; Kashiwagi M; Hirose S
    Am J Physiol Regul Integr Comp Physiol, Jun. 2001, Refereed
  • Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro
    Tomoda Y; Kikumoto K; Isumi Y; Katafuchi T; Tanaka A; Kangawa K; Dohi K; Minamino N
    Cardiovasc Res, Mar. 2001, Refereed
  • Adrenomedullin suppresses interleukin-1beta-induced tumor necrosis factor-alpha production in Swiss 3T3 cells
    Isumi Y; Kubo A; Katafuchi T; Kangawa K; Minamino N
    FEBS Lett, Dec. 1999, Refereed
  • Production of adrenomedullin in macrophage cell line and peritoneal macrophage
    Kubo A; Minamino N; Isumi Y; Katafuchi T; Kangawa K; Dohi K; Matsuo H
    J Biol Chem, Jul. 1998
  • Adrenomedullin production in fibroblasts: its possible function as a growth regulator of Swiss 3T3 cells
    Isumi Y; Minamino N; Katafuchi T; Yoshioka M; Tsuji T; Kangawa K; Matsuo H
    Endocrinology, May 1998, Refereed
  • Tissue distribution and localization of natriuretic peptide receptor subtypes in stroke-prone spontaneously hypertensive rats
    Nagase M; Katafuchi T; Hirose S; Fujita T
    J Hypertens, Nov. 1997, Refereed
  • Role of natriuretic peptide receptor type C in Dahl salt-sensitive hypertensive rats
    Nagase M; Ando K; Katafuchi T; Kato A; Hirose S; Fujita T
    Hypertension, Aug. 1997, Refereed
  • Gene expression of endothelial type isoform of nitric oxide synthase in various tissues of stroke-prone spontaneously hypertensive rats
    Seki T; Naruse M; Naruse K; Katafuchi T; Lodhi KM; Yoshimoto T; Hagiwara H; Demura H; Hirose S
    Hypertens Res, Mar. 1997, Refereed
  • Cloning and properties of a novel natriuretic peptide receptor, NPR-D
    M Kashiwagi; T Katafuchi; A Kato; H Inuyama; T Ito; H Hagiwara; Y Takei; S Hirose
    Eur J Biochem, Oct. 1995, Refereed
  • Cloning, properties, site-directed mutagenesis analysis of the subunit structure, tissue distribution and regulation of expression of the type-C eel natriuretic peptide receptor
    Takashima A; Katafuchi T; Shibasaki M; Kashiwagi M; Hagiwara H; Takei Y; Hirose S
    Eur J Biochem, Feb. 1995, Refereed
  • Cloning and expression of eel natriuretic-peptide receptor B and comparison with its mammalian counterparts
    Katafuchi T; Takashima A; Kashiwagi M; Hagiwara H; Takei Y; Hirose S.
    Eur J Biochem, Jun. 1994, Refereed
  • High-density localization of ANP receptors in chondrocytes of eel gill cartilage
    Sakaguchi H; Katafuchi T; Hagiwara H; Takei Y; Hirose S
    Am J Physiol, Aug. 1993, Refereed
  • A dramatic pH-dependent alteration in ANP receptor density: a note for using cultured cells
    Katafuchi T; Hagiwara H; Ito T; Hirose S
    Am J Physiol, May 1993, Refereed
  • Modulation by NaCl of atrial natriuretic peptide receptor levels and cyclic GMP responsiveness to atrial natriuretic peptide of cultured vascular endothelial cells
    Katafuchi T; Mizuno T; Hagiwara H; Itakura M; Ito T; Hirose S
    J Biol Chem, Apr. 1992, Refereed
    Lead
  • Bifunctional atrial natriuretic peptide receptor (type A) exists as a disulfide-linked tetramer in plasma membranes of bovine adrenal cortex
    Iwata T; Uchida-Mizuno K; Katafuchi T; Ito T; Hagiwara H; Hirose S
    J Biochem, Jul. 1991, Refereed
  • Human adrenal tumor cell line SW-13 contains a natriuretic peptide receptor system that responds preferentially to ANP among various natriuretic peptides
    Mizuno T; Katafuchi T; Hagiwara H; Ito T; Kangawa K; Matsuo H; Hirose S
    Biochem Biophys Res Commun, Dec. 1990, Refereed

MISC

  • Fatty Acid Metabolism during Exercise
    Takeshi Katafuchi and Makoto Makishima
    日大医学雑誌, 01 Feb. 2021, Not refereed, Invited
    Lead
  • Calcitonin receptor-stimulating peptide: Its evolutionary and functional relationship with calcitonin/calcitonin gene-related peptide based on gene structure.
    Katafuchi T; Yasue H; Osaki T; Minamino N.
    Peptides, 18 Jul. 2009, Refereed, Not invited
    Lead
  • Genomic organization, expression and evolution of porcine CRSP1, 2, and 3.
    Rezaeian AH; Katafuchi T; Yoshizawa M; Hiraiwa N; Saito T; Nishibori M; Hamano K; Minamino N; Yasue H
    Cytogenet Genome Res, 01 Aug. 2008, Refereed, Not invited
  • Genomic and expression analysis of canine calcitonin receptor-stimulating peptides and calcitonin/calcitonin gene-related peptide.
    Osaki T; Katafuchi T; Minamino N.
    J Biochem, 16 Jul. 2008, Refereed, Not invited
    Lead
  • A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts.
    Notoya M; Arai R; Katafuchi T; Minamino N; Hagiwara H.
    Eur J Pharmacol, 10 Apr. 2007, Refereed, Not invited
  • Membrane guanylyl cyclase receptors: an update.
    Garbers DL; Chrisman TD; Wiegn P; Katafuchi T; Albanesi JP; Bielinski V; Barylko B; Redfield MM; Burnett JC Jr.
    Trends Endocrinol Metab, 30 Jun. 2006, Refereed, Not invited
  • Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats.
    Sawada H; Yamaguchi H; Shimbara T; Toshinai K; Mondal MS; Date Y; Murakami N; Katafuchi T; Minamino N; Nunoi H; Nakazato M
    Endocrinology, 12 Jan. 2006, Refereed, Not invited
  • Isolation and characterization of a glycine-extended form of calcitonin receptor-stimulating peptide-1: Another biologically active form of calcitonin receptor-stimulating peptide-1
    Takeshi Katafuchi; Kazumasa Hamano; Katsuro Kikumoto; Naoto Minamino
    Peptides, Dec. 2005, Refereed, Not invited
  • Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1
    Kazumasa Hamano; Takeshi Katafuchi; Katsuro Kikumoto; Naoto Minamino
    Biochemical and Biophysical Research Communications, 29 Apr. 2005, Refereed, Not invited
  • Structure and biological properties of three calcitonin receptor-stimulating peptides, novel members of the calcitonin gene-related peptide family
    Takeshi Katafuchi; Naoto Minamino
    Peptides, Nov. 2004, Refereed, Not invited

Books and other publications

  • 「解明」から「制御」へ,肥満症のメディカルサイエンス
    Joint work, FGF21の生理作用・薬理作用
    羊土社, Feb. 2016, Not refereed

Lectures, oral presentations, etc.

  • 摂食同調後の給餌によるFGF15発現量低下機構の解明
    片渕剛; 本田彰; 槇島誠
    第55回日本動脈硬化学会総会・学術集会, Jul. 2024, Not invited
  • 摂食とFGF15について
    片渕剛
    日本動脈硬化学会第8回研究者育成セミナー, Jun. 2024, Invited
  • Effect of PPARγ-K107 SUMOylation on insulin sensitivity and adiposity in mice.
    Katafuchi Takeshi; David Mangelsdorf; Steven Kliewer
    The 97th Annual Meeting of the Japanese Pharmacological Society, Dec. 2023, Not invited
  • 摂食同調後の給餌によるFGF15発現量低下機構の解明
    片渕 剛; 本多 彰; 槇島 誠
    第44回胆汁酸研究会, Nov. 2023, Not invited
  • Effect of PPARγ-K107 SUMOylation on insulin sensitivity and adiposity in mice
    TAKESHI KATAFUCHI,DAVID MANGELSDORF,STEVEN KLIEWER
    日本レチノイド研究会 第33回学術集会, Oct. 2022, 日本レチノイド研究会, Not invited
  • INHIBITION OF GUANYLYL CYCLASE-B ACTIVITY BY S1P IS MEDIATED THROUGH S1P2/RHO- and S1P3/RHO-DEPENDENT PATHWAYS
    Takeshi Katafuchi and Joseph Albanesi
    The 95th Annual Meeting of the Japanese Pharmacological Society, Mar. 2022, 日本薬理学会, Not invited
  • Hepatic uptake of conjugated bile acids mediated by both NTCP and OATPs is repressed by intestinal sensing of plasma bile acid levels.
    Slijepcevic D.; Katafuchi T.; Abbing RLP.; Donkers J.; Beuers U.; Elferink RPO.; Schinkel A.; van de Graaf SF.
    67th Annual Meeting of the American Association-for-the-Study-of-Liver-Diseases, Nov. 2016, AASLD, Not invited

Courses

  • 栄養学
    Sep. 2020 - Present
    日本大学医学部附属看護専門学校

Research Themes

  • Identification of the transcription factor that reduce ileal Fgf15 expression level by the food intake after a long-term starvation
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2022 - 31 Mar. 2025
    片渕 剛
  • Postprandial reduction of FGF15 expression after starvation in mouse ileum.
    Sep. 2020 - Mar. 2022
  • Adrenomedullin, a new peptidergic factor regulating inflammation and proliferation
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1998 - 2002
    MINAMINO Naoto; KATAFUCHI Takeshi
  • ブタ腎臓上皮細胞の細胞内cAMP濃度を上昇させる新規生理活性ペプチドの解析
    日本学術振興会, 科学研究費助成事業, 2000 - 2001
    片渕 剛
  • Purification and structural determination of new vasoactive peptides and elucidation of their effects on the vascular wall cells
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1999 - 2000
    MINAMINO Naoto; KATAFUCHI Takeshi
  • 腎臓における水の再吸収を制御する新規生理活性ペプチドの精製、構造解析
    日本学術振興会, 科学研究費助成事業, 1998 - 1999
    片渕 剛
  • Production and function of adrenomedullin in the extro-cardiovascular system
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1997 - 1998
    MINAMINO Naoto; KATAFUCHI Takeshi

Industrial Property Rights

  • 2002-16277, カルシトニン受容体を活性化する新規生理活性ペプチド
    南野直人,片渕 剛