MATSUDA Hiroyuki
| School of Medicine Department of Medicine | Assistant Professor |
Researcher Information
Research Keyword
Field Of Study
Career
- Nov. 2019 - Present
Nihon University School of Medicine, Division of Medical Research Planning and Development - Nov. 2016 - Oct. 2019
日本大学医学部, 内科学系総合内科・総合診療医学分野 - Jun. 2007 - Jul. 2012
CRCCHUM, University of Montreal, 博士後研究員 - 01 Apr. 2008 - 31 Mar. 2011
日本学術振興会, 特別研究員DC1 - Apr. 2008 - Mar. 2011
日本学術振興会, 特別研究員DC1
Research activity information
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Paper
- ★Contrasting Role of COMMD5 in Renal Cell Carcinoma: Tumor Suppression and Metastatic Enhancement
HIROYUKI MATSUDA; JIN IKEDA; MAIKO OGASAWARA‐NOSOKO; MORITO ENDO; PAVEL HAMET; JOHANNE TREMBLAY
ANTICANCER RESEARCH, Apr. 2025, Refereed, Not invited
Lead - ★COMMD5 counteracts cisplatin-induced nephrotoxicity by maintaining tubular epithelial integrity and autophagy flux
Maiko Ogasawara-Nosoko; Hiroyuki Matsuda; Jin Ikeda; Masanaori Abe; Yoshikazu Masuhiro; Morito Endo; Pavel Hame; Johanne Tremblay
American Journal of Physiology-Renal Physiology, Sep. 2024, Refereed, Not invited
Corresponding - ★COMMD5 Inhibits Malignant Behavior of Renal Cancer Cells
JIN IKEDA; HIROYUKI MATSUDA; MAIKO OGASAWARA; YUKIMOTO ISHII; KENYA YAMAGUCHI; SATORU TAKAHASHI; NOBORU FUKUDA; YOSHIKAZU MASUHIRO; MORITO ENDO; MASAYOSHI SOMA; PAVEL HAMET; JOHANNE TREMBLAY
ANTICANCER RESEARCH, Jun. 2021, Refereed, Not invited
Corresponding - ★HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma
Hiroyuki Matsuda; Carole G. Campion; Kyoko Fujiwara; Jin Ikeda; Suzanne Cossette; Thomas Verissimo; Maiko Ogasawara; Louis Gaboury; Kosuke Saito; Kenya Yamaguchi; Satoru Takahashi; Morito Endo; Noboru Fukuda; Masayoshi Soma; Pavel Hamet; Johanne Tremblay
ONCOTARGET, Sep. 2017, Refereed, Not invited
Lead - ★Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.
Matsuda Hiroyuki; Hamet Pavel; Tremblay Johanne.
Journal of Nephrology, 2014, Refereed, Not invited
Lead - ★Transcriptional inhibition of progressive renal disease by gene silencing pyrrole–imidazole polyamide targeting of the transforming growth factor-β1 promoter.
Matsuda Hiroyuki; Fukuda Noboru; Ueno Takahiro; Katakawa Mayumi; Wang Xiaofei; Watanabe Takayoshi; Matsui Sei-Ichi; Aoyama Takahiko; Saito Kosuke; Bando Toshikazu; Matsumoto Yoshiaki; Nagase Hiroaki; Matsumoto Koichi; Sugiyama Hiroshi.
Kidney International, 2011, Refereed, Not invited
Lead - ★HCaRG accelerates renal tubular repair after ischemia kidney injury
Matsuda Hiroyuki; Lavoie Julie L; Gaboury Louis; Hamet Pavel; Tremblay Johanne.
Journal of American Society Nephrology, 2011, Refereed, Not invited
Lead - ★Development of gene silencing pyrrole-imidazole polyamide targeted to the TGF-ß1 promoter for treatment of progressive renal diseases.
Matsuda Hiroyuki; Fukuda Noboru; Ueno Takahiro; Tahira Yoshiko; Ayame Hirohito; Zhang Wen; Bando Toshikazu; Sugiyama Hiroshi; Saito Satoshi; Matsumoto Koichi; Mugishima Hideo; Serie Kazuo.
Journal of American Society Nephrology, 2006, Refereed, Not invited
Lead - COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking
Campion CG; Zaoui K; Verissimo T; Cossette S; Matsuda H; Solban N; Hamet P; Tremblay J
Cell Reports, Jul. 2018, Refereed, Not invited - Modulation of the EMT/MET process by pyrrole-imidazole polyamide targeting human transforming growth factor-β1.
Saito Kosuke; Fukuda Noboru; Shinohara Ken-ichi; Masuhiro Yoshikazu; Hanazawa Shigemasa; Matsuda Hiroyuki; Fujiwara Kyoko; Ueno Takahiro; Soma Masayoshi.
The International Journal of Biochemistry & Cell Biology, 2015, Refereed, Not invited - Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
Igarashi Jun; Fukuda Noboru; Inoue Takashi; Nakai Shigeki; Saito Kosuke; Fujiwara Kyoko; Matsuda Hiroyuki; Ueno Takahiro; Matsumoto Yoshiaki; Watanabe Takayoshi; Nagase Hiroki; Bando Toshikazu; Sugiyama Hiroshi; Itoh Toshio; Soma Masayoshi.
PLoS One, 2015, Refereed, Not invited - Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6.
Maruyama Takashi; Fukuda Noboru; Matsumoto Taro; Kano Koichiro; Endo Morito; Kazama Minako; Kazama Tomohiko; Ikeda Jin; Matsuda Hiroyuki; Ueno Takahiro; Abe Masanori; Okada Kazuyoshi; Soma Masayoshi; Matsumoto Koichi; Kawachi Hiroshi.
Stem Cell Research & Therapy, 2015, Refereed, Not invited - Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif.
Taniguchi Masashi; Fujiwara Kyoko; Nakai Yuji; Ozaki Toshinori; Koshikawa Nobuko; Kojima Toshio; Kataba Motoaki; Oguni Asako; Matsuda Hiroyuki; Yoshida Yukihiro; Tokuhashi Yasuaki; Fukuda Noboru; Ueno Takahiro; Soma Masayoshi; Nagase Hiroki.
FEBS Open Bio, 2014, Refereed, Not invited - RNA binding properties of novel gene silencing pyrrole-imidazole polyamides.
Iguchi Akifumi; Fukuda Noboru; Takahashi Teruyuki; Watanabe Takayoshi; Matsuda Hiroyuki; Nagase Hiroki; Bando Toshikazu; Sugiyama Hiroshi; Shimizu Kazufumi.
Biological and Pharmaceutical Bulletin, 2013, Refereed, Not invited - Development of pyrrole-imidazole polyamide targeting Fc receptor common gamma chain for the treatment of immune-complex related renal disease.
Kajiwara Mamiko; Ueno Takahiro; Fukuda Noboru; Matsuda Hiroyuki; Shimokawa Toshibumi; Kitai Maki; Tsunemi Akiko; Fuke Yoshinobu; Fujita Takayuki; Matsumoto Koichi; Matsumoto Yoshiaki; Ra Chisei; Soma Masayoshi.
Biological and Pharmaceutical Bulletin, 2012, Refereed, Not invited - Pyrrole-imidazole polyamide targeting transforming growth factor ß1 ameliorates encapsulating peritoneal sclerosis.
Serie Kazuo; Fukuda Noboru; Nakai Shigeki; Matsuda Hiroyuki; Maruyama Takashi; Murayama Yoshinobu; Omata Sadao.
Peritoneal Dialysis International, 2012, Refereed, Not invited - Development of a novel gene silencer pyrrole-imidazole polyamide targeting human connective tissue growth factor.
Wan Jian-Xin; Fukuda Noboru; Ueno Takahiro; Watanabe Takayoshi; Matsuda Hiroyuki; Saito Kosuke; Nagase Hiroki; Matsumoto Yoshiaki; Matsumoto Koichi.
Biological and Pharmaceutical Bulletin, 2011, Refereed, Not invited - Transcriptional Inhibition of Hypertrophic Scars by a Gene Silencer, Pyrrole-Imidazole Polyamide, Targeting the TGF-ß1 Promoter.
Washio Hisayo; Fukuda Noboru; Matsuda Hiroyuki; Nagase Hiroki; Watanabe Takayoshi; Matsumoto Yoshiaki; Terui Tadashi.
Journal of Investigative Dermatology., 2011, Refereed, Not invited - Pretranscriptional Regulation of Tgf-ß1 by PI Polyamide Prevents Scarring and Accelerates Wound Healing of the Cornea After Exposure to Alkali.
Chen Min; Matsuda Hiroyuki; Wang Linghua; Watanabe Takayoshi; Kimura Makoto T; Igarashi Jun; Wang Xiaofei; Sakimoto Tohru; Fukuda Noboru; Sawa Mitsuru; Nagase Hiroki.
Molecular Therapy, 2010, Refereed, Not invited - A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
Ueno Takahiro; Fukuda Noboru; Tsunemi Akiko; Yao En-Hui; Matsuda Hiroyuki; Tahira Kazunobu; Matsumoto Taro; Matsumoto Koichi; Matsumoto Yoshiaki; Nagase Hiroki; Sugiyama Hiroshi; Sawamura Tatsuya.
Journal of Hypertension, 2009, Refereed, Not invited - A pyrrole-imidazole polyamide targeting transforming growth factor-ß1 inhibits restenosis and preserves endothelialization in the injured artery.
Yao En-Hui; Fukuda Noboru; Ueno Takahiro; Matsuda Hiroyuki; Nagase Hiroki; Matsumoto Yoshiaki; Sugiyama Hiroshi; Matsumoto Koichi.
Cardiovascular Research, 2009, Refereed, Not invited - Transforming growth factor-beta as a treatment target in renal diseases.
Fukuda Noboru; Tahira Yoshiko; Matsuda Hiroyuki; Matsumoto Koichi.
Journal of Nephrology, 2009, Refereed, Not invited - Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury.
Yao En-Hui; Fukuda Noboru; Ueno Takahiro; Matsuda Hiroyuki; Matsumoto Koichi; Nagase Hiroki; Matsumoto Yoshiaki; Takasaka Ayako; Serie Kazuo; Sugiyama Hiroshi; Sawamura Tetsuya.
Hypertension, 2008, Refereed, Not invited - Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of pyrrole-imidazole polyamides in rat plasma.
Fukasawa Akiko; Nagashima Takashi; Aoyama Takahiko; Fukuda Noboru; Matsuda Hiroyuki; Ueno Takahiro; Sugiyama Hiroshi; Nagase Hiroki; Matsumoto Yoshiaki.
Journal of Chromatogrphy B Analytical Technologies in the Biomedical and Life Sciences, 2007, Refereed, Not invited - Complement 3 is involved in changing the phenotype of human glomerular mesangial cells.
Wan Jian-Xin; Fukuda Noboru; Endo Morito; Tahira Yoshiko; Yao En-Hui; Matsuda Hiroyuki; Ueno Takahiro; Matsumoto Koichi.
Journal of Cellular Physiology, 2007, Refereed, Not invited - Chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-ß1 mRNA ameliorates renal injury in hypertensive rats.
Tahira Yoshiko; Fukuda Noboru; Endo Morito; Ueno Takahiro; Matsuda Hiroyuki; Saito Satoshi; Matsumoto Koichi; Mugishima Hideo.
Journal of Hypertension, 2007, Refereed, Not invited - Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-ß1 gene.
Lai Yu-Mu; Fukuda Noboru; Ueno Takahiro; Matsuda Hiroyuki; Saito Satoshi; Matsumoto Koichi; Ayame Hirohito; Bando Toshikazu; Sugiyama Hiroshi; Mugishima Hideo; Serie Kazuo.
The journal of Pharmacology and Experimental Therapeutics, 2005, Refereed, Not invited - Effects of antisense peptide nucleic acid to platelet-derived growth factor A-chain on growth of vascular smooth muscle cells
N Fukuda; R Furuya; H Kishioka; R Suzuki; H Matsuda; Y Tahira; H Takagi; Y Ikeda; S Saito; K Matsumoto; K Kanmatsuse
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Aug. 2003, Refereed, Not invited - Effects of antisense PNA to PDGF A-chain on growth of vascular smooth muscle cells.
Fukuda Noboru; Furuya Rie; Kishioka Hirobumi; Suzuki Ryo; Matsuda Hiroyuki; Tahira Yoshiko; Takagi Hiroto; Ikeda Yukihiro; Saito Satoshi; Matsumoto Koichi; Kanmatsuse Katsuo.
Journal of Cardiovascular Pharmacology, 2003, Refereed, Not invited
MISC
- COMMD5/HCaRG による腎尿細管保護メカニズムに関する検討
松田裕之; 舛廣善和
日本大学医学部総合医学研究所紀要, 2020, Not refereed, Invited
Lead - 新規腎保護因子 HCaRG/COMMD5 を標的とした 腎臓病及び腎癌の治療法の開発
松田裕之; 舛廣善和
日本大学医学部総合医学研究所紀要, 2019, Not refereed, Invited
Lead - Effects of pyrrole-imidazole polyamide targeting LOX-1 on the apoptosis of endothelium and intimal hyperplasia in balloon-injured rat carotid artery
T. Ueno; N. Fukuda; K. Tahira; T. Matsumoto; H. Matsuda; A. Tsunemi; K. Matsumoto; H. Sugiyama; T. Sawamura
JOURNAL OF HYPERTENSION, Jun. 2008, Not refereed, Not invited - Development of a novel gene silencer PI polyamide targeting TGF-beta 1 for chronic renal diseases and restenosis of artery
H. Matsuda; N. Fukuda; E. -H. Yao; T. Ueno; H. Sugiyama; K. Matsumoto
JOURNAL OF HYPERTENSION, Jun. 2008, Not refereed, Not invited - OPTIMIZATION AND VALIDATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY WITH UV DETECTION FOR DETERMINATION OF PYRROLE-IMIDAZOLE POLYAMIDES IN RAT PLASMA
Akiko Fukasawa; Takashi Nagashima; Takahiko Aoyama; Noboru Fukuda; Hiroyuki Matsuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
DRUG METABOLISM REVIEWS, 2007, Not refereed, Not invited - ESTABLISHMENT OF SOLID-PHASE EXTRACTION METHOD FOR THE RECOVERY OF PYRROLE-IMIDAZOLE POLYAMIDES FROM RAT URINE USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY SYSTEM WITH ULTRAVIOLET DETECTOR
Takashi Nagashima; Akiko Fukasawa; Takahiko Aoyama; Noboru Fukuda; Hiroyuki Matsuda; Takahiro Ueno; Hiroshi Sugiyama; Hiroki Nagase; Yoshiaki Matsumoto
DRUG METABOLISM REVIEWS, 2007, Not refereed, Not invited - Pyrrole-imidazole polyamide targeting human lectin-like oxidized LDL receptor 1 gene reduced endothelial cell apoptosis induced by angiotensin II and oxidized LDL
Takahiro Ueno; Noboru Fukuda; Akiko Tsunemi; Kazunobu Tahira; Taro Matsumoto; Hiroyuki Matsuda; Siro Matsumoto; Koichi Matsumoto; Hiroshi Sugiyama; Tatsuya Sawamura
JOURNAL OF HYPERTENSION, Dec. 2006, Not refereed, Not invited - Effects of synthetic pyrrole-imidazole polyamide targeting TGF-b1 promoter on TGF-b1 expression and renal injury in rats
H Matsuda; N Fukuda; T Ueno; K Matsumoto; H Sugiyama
JOURNAL OF GENE MEDICINE, Mar. 2006, Not refereed, Not invited - Effects of synthetic pyrrole-imidazole polyamide targeting TGF-b1 promoter on TGF-b1 expression and renal injury in rats
H Matsuda; N Fukuda; T Ueno; K Matsumoto; H Sugiyama
JOURNAL OF GENE MEDICINE, Mar. 2006, Not refereed, Not invited - Development of pyrrole-imidazole polyamides targeting TGF-beta 1 promoter as a gene therapy for the arterial proliferative diseases
Y Lai; N Fukuda; H Kishioka; H Matsuda; S Saito; K Matsumoto; K Kanmatsuse; H Sugiyama
ATHEROSCLEROSIS SUPPLEMENTS, Sep. 2003, Not refereed, Not invited
Lectures, oral presentations, etc.
- ★COMMD5によるE-cadherin制御が腎障害を抑えるメカニズムの検討
第65回日本腎臓学会学術総会, Jun. 2022, Not invited - ★急性腎障害におけるCOMMD5のミトコンドリア保護メカニズムの検討
松田裕之; 小笠原茉衣子; 遠藤守人
第64回日本腎臓学会学術総会, Jun. 2021, Not invited - 高血圧関連遺伝子 COMMD5/HCaRG の Autophagy 制御を介した尿細管保護 作用の検討
小笠原茉衣子; 松田裕之; 福田昇; Hamet Pavel; Tremblay Johanne
第55回高血圧関連疾患モデル学会 第29回日本循環薬理学会 合同学会, Nov. 2019, Not invited - 急性腎障害における高血圧関連遺伝子 COMMD5/HCaRG の尿細管保護メカニ ズムの検討
松田裕之; 小笠原茉衣子; 池田迅; 遠藤守人; 福田昇; Hamet Pavel; Tremblay Johanne
第55回高血圧関連疾患モデル学会 第29回日本循環薬理学会 合同学会, Nov. 2019, Not invited - 高血圧関連遺伝子 COMMD5/HCaRG は腎がん幹細胞の働きを抑制し、腫瘍増 大や血管新生を抑制する
池田迅; 松田裕之; 小笠原茉衣子; 遠藤守人; 福田昇; Hamet Pavel; Tremblay Johanne
第55回高血圧関連疾患モデル学会 第29回日本循環薬理学会 合同学会, Nov. 2019, Not invited - 急性腎障害におけるCOMMD5のAutophagy制御メカニズムの検討
小笠原茉衣子; 松田裕之; 遠藤守人; 福田昇
第62回日本腎臓学会学術総会, Jun. 2019, Not invited - 薬剤性腎障害におけるCOMMD5の尿細管保護メカニズムの検討
松田裕之; 小笠原茉衣子; 福田昇; 遠藤守人
第62回日本腎臓学会学術総会, Jun. 2019, Not invited - 高血圧関連遺伝子COMMD5のオートファジーを介した腎尿細管保護作用についての検討
小笠原茉衣子; 池田迅; 矢内充; 遠藤守人; 福田昇; 松田裕之; Hamet Pavel; Tremblay Johanne
第54回高血圧関連疾患モデル学会学術総会, Dec. 2018, Not invited - HCaRGはRenal tubular epithelial cell barrier機能を増強し急性腎障害を予防する
松田裕之; 池田迅; 小笠原茉衣子; 矢内充; 福田昇; 相馬正義; Hamet Pavel; Tremblay Johanne
第61回日本腎臓学会学術総会, Jun. 2018, Not invited - Campylobacter fetus-infected Aneurysm: Case Report and Literature Review 1971–2016
Suzuki Kiyozumi; Yanai Mitsuru; Ogasawara Maiko; Ohashi Akira; Konagai Makoto; Hayashi Yuta; Otsuka Hiromasa; Matsuda Hiroyuki; Kato Kimitoshi; Soma Masayoshi
30th International Congress of Chemotherapy and Infection 2017, Nov. 2017, Not invited - 新規腎保護因子HCaRG/COMMD5は腎細胞癌の腫瘍形成を抑制する
松田裕之
第30回 インターフェックスジャパン, Jun. 2017, Not invited - HCaRG/COMMD5 improves kidney repair by regulating EGF receptor trafficking
Tremblay Johanne; Campion Carole G; Verissimo Thomas; Cossette Suzanne; Matsuda Hiroyuki; Hamet Pave
27th European Meeting on Hypertension and Cardiovascular Protection, Jun. 2017, Not invited - 近位尿細管でのHCaRGの発現低下は、慢性腎臓病や腎細胞癌を進展させる原因となる
池田迅; 松田裕之; 福田昇; 矢内充; 相馬正義; Hamet Pavel; Tremblay Johanne
第60回日本腎臓学会学術総会, May 2017, Not invited - HCaRGはRenal tubular epithelial cell barrier機能を増強し急性腎障害を予防する
松田裕之; 池田迅; 小笠原茉衣子; 矢内充; 福田昇; 相馬正義; Hamet Pavel; Tremblay Johanne
第60回日本腎臓学会学術総会, May 2017, Not invited - 新規高血圧関連遺伝子HCaRGはErbB受容体に依存した腎細胞癌の腫瘍増大や血管新生を抑制する
池田迅; 松田裕之; 福田昇; 相馬正義; Hamet Pavel; Tremblay Johanne
第105回 日本泌尿器科学会総会, Apr. 2017, Not invited
Research Themes
- COMMD5-レトリーバー複合体によるフェロトーシス制御に着目した腎保護に関する研究
日本学術振興会, 科学研究費助成事業, Apr. 2024 - Mar. 2027
松田 裕之 - COMMD5による急性腎障害から慢性腎臓病への進展予防メカニズムの解明
科学研究費助成金･基盤研究C, Apr. 2021 - Mar. 2024
松田裕之 - 腎尿細管上皮バリアによる腎性貧血の進展抑制メカニズムの検討
公益財団法人 日本腎臓財団, CKD(慢性腎臓病)病態研究助成, Dec. 2020 - Mar. 2022
松田裕之 - HCaRG/COMMD5は腎尿細管上皮バリアー機構を増強し急性腎障害を改善する
Apr. 2018 - Mar. 2021
松田裕之 - 新規腎保護因子HCaRG/COMMD5を標的とした腎臓病及び腎癌の治療法の開発
Apr. 2018 - Mar. 2020
松田裕之, 舛廣義和 - 新規尿細管保護因子HCaRGの腎細胞癌予後因子としての有用性と新たなる予防法への応用
Apr. 2017 - Mar. 2018
松田裕之 - 新規高血圧関連遺伝子HCaRGは生活習慣病に起因する腎癌の発症を抑制する
Japan Society for the Promotion of Science, 科学研究費助成金, Oct. 2015 - Mar. 2018
MATSUDA Hiroyuki; YAMAGUCHI Kenya; MATSUMOTO Taro; ENDO Morito; KATAKAWA Mayumi; IKEDA Jin; TREMBLAY Johanne - 新規高血圧関連遺伝子HCaRGによるオートファジーの誘導を介した腎尿細管保護作用
アステラス製薬, エーキューブ, Jan. 2014 - Dec. 2015
松田裕之; 相馬正義 - 新規高血圧関連遺伝子HCaRGは腎細胞癌の腫瘍形成を抑制する
Japan Society for the Promotion of Science, 科学研究費助成金, Apr. 2013 - Mar. 2015
MATSUDA Hiroyuki - 進行性腎障害の治療のためのTGF-β1標的新規遺伝子制御薬、PIポリアミドの創薬
日本学術振興会, 科学研究費補助金, Apr. 2008 - Mar. 2011
松田 裕之 - -
日本学術振興会, 研究者海外派遣基金助成金, Dec. 2009 - Sep. 2010
松田裕之 - 進行性腎障害の治療のためのTGF-β1プロモーターを標的とした新規遺伝子制御薬、PI polyamideの開発
Apr. 2007 - Mar. 2008
松田裕之
