Life sciences, Metabolism and endocrinology, Metabolomics

Apr. 1997 - Mar. 2001
The University of Tokyo, Medicine, Internal Medicine

Apr. 1989 - Mar. 1995
Kyushu University, Medicine, Medicine

★Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes.
Fujishiro M; Ishihara H; Ogawa K; Murase T; Nakamura T; Watanabe K; Sakoda H; Ono H; Yamamotoya T; Nakatsu Y; Asano T; Kushiyama A
Biomedicines, Aug. 2021, Refereed
Lead

Acetonemic vomiting: a potential complication of treatment with glucagon-like peptide-1 receptor agonists especially in lean type 2 diabetes patients.
Midori Fujishiro; Maiko Nosoko; Jin Ikeda; Misaki Takeuchi; Takeshi Yamamotoya; Tadateru Takayama; Tatsuhiko Urakami; Katsuhiko Ogawa; Hisamitsu Ishihara
Diabetology international, Jan. 2025

健常成人に生じたクリプトコッカス性髄膜炎の1例
小川 克彦; 杉山 諒太; 藤城 緑; 高山 忠輝; 中嶋 秀人
日本プライマリ・ケア連合学会学術大会, Jun. 2024

Sox11はクロマチンリモデラー遺伝子の発現制御によってインスリン分泌応答を統御する
小須田 南; 藤城 緑; 田久保 正洋; 渡邉 健太郎; 石原 寿光
糖尿病, Apr. 2024

Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action.
Takeshi Yamamotoya; Yukino Ohata; Yasuyuki Akasaka; Shun Hasei; Masa-Ki Inoue; Yusuke Nakatsu; Machi Kanna; Hiroki Yamazaki; Akifumi Kushiyama; Midori Fujishiro; Hiraku Ono; Hideyuki Sakoda; Tetsuya Yamada; Hisamitsu Ishihara; Tomoichiro Asano
PNAS nexus, Apr. 2024

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells.
Yasuyuki Akasaka; Shun Hasei; Yukino Ohata; Machi Kanna; Yusuke Nakatsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Hiraku Ono; Akio Matsubara; Nobuyuki Hinata; Tomoichiro Asano; Takeshi Yamamotoya
International journal of molecular sciences, Nov. 2023

教育入院が行動変容に繋がったアドヒアランス不良の2型糖尿病合併高度肥満症の一例
池田 迅; 武内 美咲; 小川 克彦; 鈴木 裕; 高山 忠輝; 石原 寿光; 藤城 緑
肥満研究, Nov. 2023

Clinical study of 16 patients with thalamic infarction.
Ogawa K; Akimoto T; Hara M; Fujishiro M; Nakajima H
Neurology and Clinical Neuroscience, Sep. 2023, Refereed

Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines
Machi Kanna; Yusuke Nakatsu; Takeshi Yamamotoya; Akifumi Kushiyama; Midori Fujishiro; Hideyuki Sakoda; Hiraku Ono; Koji Arihiro; Tomoichiro Asano
International Journal of Molecular Sciences, May 2023, Refereed

Association of Glycated Hemoglobin Level with Self-Reported Chewing Problems in Elderly Community-Dwelling Individuals in Japan
Midori Fujishiro; Sho Tanaka; Kentaro Watanabe; Kazuhiro Imatake; Yasuyuki Suzuki; Hisamitsu Ishihara; Shigemasa Tani
Journal of Multidisciplinary Healthcare, May 2023, Refereed
Lead

A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness
Aya Tanaka; Minami Kosuda; Midori Yamana; Asami Furukawa; Akiko Nagasawa; Midori Fujishiro; Genta Kohno; Hisamitsu Ishihara
Scientific Reports, Apr. 2023, Refereed

Two Patients with Spontaneous Spinal Epidural Hematoma Carrying a Good Prognosis without Surgical Operations
Katsuhiko Ogawa; Takayoshi Akimoto; Makoto Hara; Midori Fujishiro; Hiroshi Uei; Hideto Nakajima
Neurology International, Mar. 2023, Refereed

グルコース応答性インスリン分泌におけるTCA回路酵素の役割の検討
河野 玄太; 盛川 愛; 小須田 南; 三枝 太郎; 藤城 緑; 渡邉 健太郎; 石原 寿光
糖尿病, Apr. 2022

本邦高齢者における咬合不良の自覚症状とHbA1c値の関係性の検討結果
田中 翔; 藤城 緑; 渡邉 健太郎; 今武 和弘; 鈴木 康之; 谷 樹昌; 石原 寿光
糖尿病, Apr. 2022

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases.
Yamamotoya T; Hasei S; Akasaka Y; Ohata Y; Nakatsu Y; Kanna M; Fujishiro M; Sakoda H; Ono H; Kushiyama A; Misawa H; Asano T.
Scientific Reports, Feb. 2022, Refereed

Impact of Female Sex on the Susceptibility to Hypernatremia Among Older Community-Dwelling Individuals in Japan.
Tanaka S; Fujishiro M; Imatake K; Suzuki Y; Ishihara H; Tani S
International Journal of General Medicine, Jan. 2022
Corresponding

A case of atypical capsular warning syndrome of long duration.
Ogawa K; Akimoto T; Hara M; Suzuki Y; Fujishiro M; Nakajima H
Journal of Nihon University Medical Association, 2022

Clinical study of cerebral ischemia in moyamoya disease from the view of development of the anterior choroidal artery.
Ogawa K; Suma T; Akimoto T; Hara M; Fujishiro M; Yoshino A; Nakajima H
Journal of Stroke and Cerebrovascular Diseases, Nov. 2021, Refereed

A case of cutis verticis gyrata-mental retardation syndrome accompanied by various neurological abnormalities.
Ogawa K; Akimoto T; Hara M; Fujishiro M; Nakajima H
Neurology and Clinical Neuroscience, Nov. 2021, Refereed

Pathological role of Pin1 in the development of DSS-induced colitis.
Matsunaga Y; Hasei S; Yamamotoya T; Honda H; Kushiyama A; Sakoda H; Fujishiro M; Ono H; Ito H; Okabe T; Asano T; Nakatsu Y
Cells, May 2021, Refereed

Tuberculosis relapse in the epididymis after the completion of nine months of anti-tuberculosis chemotherapy in a patient with poorly-controlled diabetes mellitus.
Ichikawa C; Tanaka S; Takubo M; Kushimoto M; Ikeda J; Ogawa K; Tsujino I; Suzuki Y; Abe M; Ishihara H; Fujishiro M
Therapeutics and Clinical Risk Management, May 2021, Refereed
Last

Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells.
Hasei S; Yamamotoya T; Nakatsu Y; Ohata Y; Itoga S; Nonaka Y; Matsunaga Y; Sakoda H; Fujishiro M; Kushiyama A; Asano T
International Journal of Molecular Sciences, Apr. 2021, Refereed

Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis.
Nakatsu Y; Yamamotoya T; Okumura M; Ishii T; Kanamoto M; Naito M; Nakanishi M; Aoyama S; Matsunaga Y; Kushiyama A; Sakoda H; Fujishiro M; Ono H; Asano T
Metabolism, Feb. 2021, Refereed

Clinical study of seven patients with infarction in the territory of the anterior choroidal artery.
Ogawa K; Akimoto T; Hara M; Fujishiro M; Suzuki Y; Soma M; Nakajima H
Journal of Nihon University Medical Association, 2021

Effect of Adult Weight Gain on Non-Alcoholic Fatty Liver Disease and Its Association with Anthropometric Parameters in the Lean Japanese Population.
Tanaka S; Fujishiro M; Watanabe K; Imatake K; Suzuki Y; Abe M; Ishihara H; Tani S
Diagnostics, Oct. 2020
Corresponding

A case of prosopometamorphopsia caused by infarction of the splenium of the corpus callosum and major forceps
Ogawa K; Akimoto T; Takahashi K; Hara M; Morita A; Kamei S; Nakajima H; Fujishiro M; Suzuki Y; Soma M; Shikata E; Futamura A; Kawamura M
Neurocase, Oct. 2020, Refereed, Not invited

Seasonal variation in hydration status among community-dwelling elderly in Japan
Tanaka S; Fujishiro M; Watanabe K; Imatake K; Suzuki Y; Abe M; Ishihara H; Tani S
Geriatrics & Gerontology International, Oct. 2020, Refereed, Not invited
Corresponding

Comparison of tofogliflozin versus glimepiride as the third oral agent added to metformin plus DPP-4 inhibitor in Japanese type 2 diabetes patients: a randomized, 24-week, open label, controlled trial (STOP-OB)
Kitazawa T; Seino H; Ohashi H; Inazawa T; Inoue M; Ai M; Fujishiro M.; Kuroda H; Yamada M; Anai M; Ishihara H
Diabetes, Obesity and Metabolism, Sep. 2020, Refereed, Not invited

2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究(続報)
藤城 緑; 櫛山 暁史; 小川 克彦; 渡邉 健太郎; 江頭 富士子; 岡本 真由美; 村瀬 貴代; 中村 敬志; 赤利 精悟; 迫田 秀之; 小野 啓; 山本屋 武; 中津 祐介; 浅野 知一郎; 石原 寿光
糖尿病, Aug. 2020

Inverse correlation between grip strength and serum phosphorus: a retrospective observational study in Japanese elderly with poorly controlled type 2 diabetes
Tanaka S; Takubo M; Kohno G; Kushimoto M; Ikeda J; Ogawa K; Suzuki Y; Abe M; Ishihara H; Fujishiro M
Geriatrics (Basel), May 2020, Refereed, Not invited
Corresponding

Associated with Prophylactic Low-Dose Trimethoprim during Systemic Corticosteroid Therapy for AQP4-Positive Optic Neuritis in a Diabetic Patient
Takubo M; Tanaka S; Kushimoto M; Ikeda J; Ogawa K; Suzuki Y; Abe M; Ishihara H; Fujishiro M
Antibiotics, Apr. 2020, Refereed, Not invited
Corresponding

A Single Episode of Hypoglycemia as a Possible Early Warning Sign of Adrenal Insufficiency
Tanaka S; Abe M; Kohno G; Kushimoto M; Ikeda J; Ogawa K; Suzuki Y; Ishihara H; Fujishiro M.
Therapeutics and Clinical Risk Management, Feb. 2020, Refereed, Not invited
Corresponding

Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.
Nakatsu Y; Yamamotoya T; Ueda K; Ono H; Inoue M; Matsunaga Y; Kushiyama A; Sakoda H; Fujishiro M; Matsubara A; Asano T
Cancer Letters, Feb. 2020, Refereed, Not invited

Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report
Tanaka S; Kushimoto M; Nishizawa T; Takubo M; Mitsuke K; Ikeda J; Fujishiro M; Ogawa K; Tsujino I; Suzuki Y; Abe M
Clinical Diabetes and Endocrinology, Jan. 2020, Refereed, Not invited

Acute esophageal necrosis after cellulitis in an obese patient with diabetes mellitus
Tanaka S; Fujishiro M; Ichijima R; Kohno G; Abe M; Ishihara H
Journal of Diabetes Investigation, Jan. 2020, Refereed, Not invited
Corresponding

Clinical study of thirteen patients with spinal cord infarction
Ogawa K; Akimoto T; Hara M; Morita A; Fujishiro M; Suzuki Y; Soma M; Kamei S; Nakajima H
Journal of Stroke and Cerebrovascular Diseases, Dec. 2019, Refereed, Not invited

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins
Inoue MK; Nakatsu Y; Yamamotoya T; Hasei S; Kanamoto M; Naitou M; Matsunaga Y; Sakoda H; Fujishiro M; Ono H; Kushiyama A; Asano T
Cells, Nov. 2019, Refereed, Not invited

典型的症状に欠く急性壊死性食道炎を的確に診断し得た鼠径部蜂窩織炎合併2型糖尿病の肥満男性
田久保 正洋; 田中 翔; 河野 玄太; 池田 迅; 石原 寿光; 藤城 緑
肥満研究, Oct. 2019

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
Mizuno Y; Yamamotoya T; Nakatsu Y; Ueda K; Matsunaga Y; Inoue MK; Sakoda H; Fujishiro M; Ono H; Kikuchi T; Takahashi M; Morii K; Sasaki K; Masaki T; Asano T; Kushiyama A
International Journal of Molecular Sciences, Sep. 2019, Refereed, Not invited

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice.
Inoue MK; Matsunaga Y; Nakatsu Y; Yamamotoya T; Ueda K; Kushiyama A; Sakoda H; Fujishiro M; Ono H; Iwashita M; Sano T; Nishimura F; Morii K; Sasaki K; Masaki T; Asano T
Diabetology & Metabolic Syndrome, Jul. 2019, Refereed, Not invited

Two Adult Siblings With Myotonic Dystrophy Type 1 With Different Phenotypes Presenting With Chronic Respiratory Insufficiency and Sleep Apnea Syndrome
Kohno G; Ogawa K; Kushimoto M; Tanaka S; Ikeda J; Nishizawa T; Mitsuke K; Nakayama T; Suzuki Y; Ishihara H; Fujishiro M
Frontiers in Neurology, Jul. 2019, Refereed, Not invited
Corresponding

MIN6細胞における解糖系中間体によるインスリン産生制御
山名 碧; 長澤 瑛子; 小須田 南; 山口 賢; 江頭 富士子; 藤城 緑; 渡邉 健太郎; 石原 寿光
糖尿病, Apr. 2019

2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究
藤城 緑; 櫛山 暁史; 小川 克彦; 山口 賢; 渡邉 健太郎; 村瀬 貴代; 中村 敬志; 赤利 精悟; 山本屋 武; 中津 祐介; 浅野 知一郎; 石原 寿光
糖尿病, Apr. 2019

Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.
Yusuke Nakatsu; Yasuka Matsunaga; Takeshi Yamamotoya; Koji Ueda; Masa-Ki Inoue; Yu Mizuno; Mikako Nakanishi; Tomomi Sano; Yosuke Yamawaki; Akifumi Kushiyama; Hideyuki Sakoda; Midori Fujishiro; Akihide Ryo; Hiraku Ono; Tohru Minamino; Shin-Ichiro Takahashi; Haruya Ohno; Masayasu Yoneda; Kei Takahashi; Hisamitsu Ishihara; Hideki Katagiri; Fusanori Nishimura; Takashi Kanematsu; Tetsuya Yamada; Tomoichiro Asano
Cell reports, Mar. 2019, Refereed, Not invited

Retention of aberrant cortisol secretion in a patient with bilateral macronodular adrenal hyperplasia after unilateral adrenalectomy. Therapeutics and Clinical Risk Management
Tanaka S; Fujishiro M; Nakamura Y; Hatanaka Y; Abe M
Therapeutics and Clinical Risk Management, 2019, Refereed, Not invited

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.
Ueda K; Nakatsu Y; Yamamotoya T; Ono H; Inoue Y; Inoue M; Mizuno Y; Matsunaga Y; Kushiyama A; Sakoda H; Fujishiro M; Takahashi S; Matsubara A; Asano T
Oncotarget, 2019, Refereed, Not invited

2型糖尿病を対象としたキサンチン酸化還元酵素の血管合併症発症および進展に対する影響に関する探索研究
藤城 緑; 櫛山 暁史; 山口 賢; 渡邉 健太郎; 江頭 富士子; 岡本 真由美; 村瀬 貴代; 中村 敬志; 山本屋 武; 中津 祐介; 浅野 知一郎; 石原 寿光
糖尿病, Apr. 2018

Trk-fused gene(TFG)の糖代謝調節における役割の解明
山本屋 武; 中津 祐介; 上田 晃嗣; 井上 賢紀; 迫田 秀之; 藤城 緑; 櫛山 暁史; 石原 寿光; 浅野 知一郎
糖尿病, Apr. 2018

Gut microbiota as a therapeutic target for metabolic disorders
Hirofumi Okubo; Yusuke Nakatsu; Akifumi Kushiyama; Takeshi Yamamotoya; Yasuka Matsunaga; Masa-Ki Inoue; Midori Fujishiro; Hideaki Sakoda; Haruya Ohno; Masayasu Yoneda; Hiraku Ono; Tomoichiro Asano
Current Medicinal Chemistry, Mar. 2018, Refereed, Not invited

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages.
Yamazaki H; Kushiyama A; Sakoda H; Fujishiro M; Yamamotoya T; Nakatsu Y; Kikuchi T; Kaneko S; Tanaka H; Asano T.
Mediators of Inflammation, 2018, Refereed, Not invited

Rationale and Design of the STOP-OB Study for Evaluating the Effects of Tofogliflozin and Glimepiride on Fat Deposition in Type 2 Diabetes Patients Treated with Metformin/DPP-4 Inhibitor Dual Therapy
Ishihara H; Anai M; Seino H; Kitazawa T; Ohashi H; Ai M; Inoue M; Fujishiro M; Inazawa T; Kuroda H; Yamada M.
Diabetes Therapy, 2018, Refereed, Not invited

Elsberg syndrome related to Varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes.
Saito H; Ebashi M; Kushimoto M; Ikeda J; Egashira F; Yamaguchi S; Watanabe K; Ogawa K; Suzuki Y; Ishihara H; Fujishiro M
Therapeutics and Clinical Risk Management, 2018, Refereed, Not invited
Corresponding

Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications
Okubo H; Kushiyama A; Nakatsu Y; Yamamotoya T; Matsunaga Y; Fujishiro M; Sakoda H; Ohno H; Yoneda M; Asano T.
International Journal of Molecular Sciences, 2018, Refereed, Not invited

Development of Pin1 inhibitors and their potential as therapeutic agents.
Nakatsu Y; Matsunaga Y; Ueda K; Yamamotoya T; Inoue Y; Inoue MK; Mizuno Y; Kushiyama A; Ono H; Fujishiro M; Ito H; Okabe T; Asano T.
Current Medicinal Chemistry, 2018, Refereed, Not invited

The xanthine oxidase inhibitor febuxostat suppresses the progression of IgA nephropathy possibly via its anti-inflammatory and anti-fibrotic effects in the gddY mouse model.
Inoue M; Yamamotoya T; Nakatsu Y; Ueda K; Inoue Y; Matsunaga Y; Sakoda H; Fujishiro M; Ono H; Mori K; Sasaki K; Masaki T; Suzuki Y; Asano T; Kushiyama A.
International Journal of Molecular Sciences, 2018, Refereed, Not invited

Ggastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus
Midori Fujishiro; Akifumi Kushiyama; Hiroki Yamazaki; Sunao Kaneko; Yuko Koketsu; Takeshi Yamamotoya; Takako Kikuchi; Hideyuki Sakoda; Ryo Suzuki; Takashi Kadowaki
WORLD JOURNAL OF GASTROENTEROLOGY, Sep. 2017, Refereed, Not invited
Lead

The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice
Yusuke Nakatsu; Hiroki Kokubo; Batmunkh Bumdelger; Masao Yoshizumi; Takeshi Yamamotoya; Yasuka Matsunaga; Koji Ueda; Yuki Inoue; Masa-Ki Inoue; Midori Fujishiro; Akifumi Kushiyama; Hiraku Ono; Hideyuki Sakoda; Tomoichiro Asano
International Journal of Molecular Sciences, Aug. 2017, Refereed

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion
Yusuke Nakatsu; Keiichi Mori; Yasuka Matsunaga; Takeshi Yamamotoya; Koji Ueda; Yuki Inoue; Keiko Mitsuzaki-Miyoshi; Hideyuki Sakoda; Midori Fujishiro; Suguru Yamaguchi; Akifumi Kushiyama; Hiraku Ono; Hisamitsu Ishihara; Tomoichiro Asano
Journal of Biological Chemistry, Jul. 2017, Refereed

新規効率的遺伝子改変インスリン分泌細胞株作製法を用いた炭酸脱水酵素の役割の解析
小須田 南; 田中 彩; 古川 麻美; 堀田 瑛子; 山名 碧; 大塚 雄一郎; 藤城 緑; 山口 賢; 石原 寿光
日本内分泌学会雑誌, Apr. 2017

インスリン分泌MIN6細胞でのグルコース応答性インスリン分泌における炭酸脱水酵素の役割
小須田 南; 田中 彩; 古川 麻美; 堀田 瑛子; 山名 碧; 大塚 雄一郎; 藤城 緑; 山口 賢; 石原 寿光
糖尿病, Apr. 2017

Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Yamamotoya T; Nakatsu Y; Matsunaga Y; Fukushima T; Yamazaki H; Kaneko S; Fujishiro M; Kikuchi T; Kushiyama A; Tokunaga F; Asano T; Sakoda H.
International Journal of Molecular Sciences, Feb. 2017, Refereed, Not invited

Severe Hypertriglyceridemia Possibly Masked Acute Pancreatitis and Led to a Difficult Diagnosis in an Obese Patient with Ketoacidosis-onset Type 2 Diabetes
Midori Fujishiro; Akiko Horita; Hiroshi Nakagawara; Takayuki Mawatari; Yoshifusa Kishigami; Yoshiteru Tominaga; Mitsuhiko Moriyama; Hisamitsu Ishihara
INTERNAL MEDICINE, 2017, Refereed, Not invited
Lead

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity
1.Yamamotoya T; Nakatsu Y; Kushiyama A; Matsunaga Y; Ueda K; Inoue Y; Inoue M; Sakoda H; Fujishiro M; Ono H; Kiyonari H; Ishihara H; Asano T
Scientific Reports, 2017, Refereed, Not invited

A case of insulin allergy successfully managed using multihexamer-forming insulin degludec combined with liraglutide.
Fujishiro M; Izumida Y; Takemiya S; Kuwano Y; Takamoto I; Suzuki R; Yamauchi T; Ueki K; Kadowaki T.
Diabetic Medicine, Nov. 2016, Refereed, Not invited
Lead

Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.
Nakatsu Y; Matsunaga Y; Yamamotoya T; Ueda K; Inoue Y; Mori K; Sakoda H; Fujishiro M; Ono H; Kushiyama A; Asano T.
International Journal of Molecular Sciences, Sep. 2016, Refereed, Not invited

Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.
Okubo H; Kushiyama A; Sakoda H; Nakatsu Y; Iizuka M; Taki N; Fujishiro M; Fukushima T; Kamata H; Nagamachi A; Inaba T; Nishimura F; Katagiri H; Asahara T; Yoshida Y; Chonan O; Encinas J; Asano T.
Sci Rep, 2016, Refereed, Not invited

Controversy regarding gastric cancer and diabetes
Midori Fujishiro; Hisamitsu Ishihara
JOURNAL OF GASTROENTEROLOGY, Jan. 2016, Refereed, Not invited
Lead

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.
Kushiyama A; Nakatsu Y; Matsunaga Y; Yamamotoya T; Mori K; Ueda K; Inoue Y; Sakoda H; Fujishiro M; Ono H; Asano T
Mediators of Inflammation, 2016, Refereed, Not invited

膵β細胞機能におけるプロリン異性化酵素Pin1の役割
中津 祐介; 森 馨一; 松永 泰花; 山本屋 武; 迫田 秀之; 藤城 緑; 櫛山 暁史; 石原 寿光; 浅野 知一郎
糖尿病, Apr. 2015

次亜塩素酸ナトリウムを用いたアルカプトン尿の簡易検査法。
毛利真理子; 田中雅美; 影山祐子; 宿谷賢一; 大久保滋夫; 藤城緑; 下澤達雄; 矢冨裕
医学検査, 2015, Refereed, Not invited

Mosapride citrate improves non-alcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.
Okubo H; Nakatsu Y; Sakoda H; Kushiyama A; Fujishiro M; Fukushima T; Matsunaga Y; Ohno H; Yoneda M; Kamata H; Shinjo T; Iwashita M; Nishimura F; Asano T.
American Journal of Physiology - Gastrointestinal & Liver Physiology, 2015, Refereed, Not invited

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Nakatsu Y; Seno Y; Kushiyama A; Sakoda H; Fujishiro M; Katasako A; Mori K; Matsunaga Y; Fukushima T; Kanaoka R; Yamamotoya T; Kamata H; Asano T.
Am J Physiol Gastrointest Liver Physiol., 2015, Refereed, Not invited

DPP-4 inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
Takanori Shinjo; Yusuke Nakatsu; Misaki Iwashita; Tomomi Sano; Hideyuki Sakoda; Hisamitsu Ishihara; Akifumi Kushiyama; Midori Fujishiro; Toshiaki Fukushima; Yoshihiro Tsuchiya; Hideaki Kamata; Fusanori Nishimura; and Tomoichiro Asano.
Am J Physiol Endocrinol Metab, 2015, Refereed, Not invited

Pin1 inhibitor Juglone exerts anti-oncogenic effects on LNCaP and DU145 cells despite the patterns of gene regulation by Pin1 differing between these cell lines.
Ryuhei Kanaoka; Akifumi Kushiyama; Yasuyuki Seno; Yusuke Nakatsu; Yasuka Matsunaga; Toshiaki Fukushima; Yoshihiro Tsuchiya; Hideyuki Sakoda; Midori Fujishiro; Takeshi Yamamotoya; Hideaki Kamata; Akio Matsubara; Tomoichiro Asano.
PLoS One, 2015, Refereed, Not invited

LUBAC formation is impaired in the livers of mice with MCD-dependent non-alcoholic steatohepatitis.
Yasuka Matsunaga; Yusuke Nakatsu; Toshiaki Fukushima; Hirofumi Okubo; Misaki Iwashita; Hideyuki Sakoda; Midori Fuhishiro; Takeshi Yamamotoya; Akifumi Kushiyama; Shin-Ichiro Takahashi; Yoshihiro Tsuchiya; Hideaki Kamata; Fuminori Tokunaga; Kazuhiro Iwai and Tomoichiro Asano.
Mediators of Inflammation, 2015, Refereed, Not invited

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.
Shinjo Takanori; Nakatsu Yuke; Iwashita Misaki; Sano Tomomi; Sakoda Hideyuki; Ishihara Hisamitsu; Kushiyama Akifumi; Fujishiro Midori; Nishimura Fusanori and Asano Tomoichiro
Diabetology and Metabolic Syndrome, 2015, Refereed, Not invited

Prolyl Isomerase Pin1 Negatively Regulates AMPK by Associating with the CBS Domain in the γ-subunit.
Nakatsu Y; Iwashita M; Sakoda H; Ono H; Nagata K; Matsunaga Y; Fukushima T; Fujishiro M; Kushiyama A; Kamata H; Takahashi SI; Katagiri H; Honda H; Kiyonari H; Uchida T; Asano T.
J Biol Chem, 2015, Refereed, Not invited

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.
Qiang S; Nakatsu Y; Seno Y; Fujishiro M; Sakoda H; Kushiyama A; Mor. K; Matsunaga Y; Yamamotoya T; Kamata H; Asano T.
Diabetol Metab Syndr, 2015, Refereed, Not invited

非アルコール性脂肪肝炎発症におけるLUBAC形成障害の役割
松永 泰花; 中津 祐介; 鎌田 英明; 福嶋 俊明; 岩下 未咲; 新城 尊徳; 菊池 貴子; 藤城 緑; 浅野 知一郎
糖尿病, Apr. 2014

Lung abscess without sepsis in a patient with diabetes with refractory episodes of spontaneous hypoglycemia: a case report and review of the literature
Gotaro Toda; Midori Fujishiro; Tomohide Yamada; Nobuhiro Shojima; Hideyuki Sakoda; Ryo Suzuki; Toshimasa Yamauchi; Kohjiro Ueki; Takashi Kadowaki
Journal of Medical Case Reports, Feb. 2014, Refereed
Corresponding

Detection of novel visible-light region absorbance peaks in the urine after alkalization in patients with alkaptonuria.
Tokuhara Y; Shukuya K; Tanaka M; Mouri M; Ohkawa R; Fujishiro M; Takahashi T; Okubo S; Yokota H; Kurano M; Ikeda H; Yamaguchi S; Inagaki S; Ishige-Wada M; Usui H; Yatomi Y; Shimosawa T.
PLoS One, 2014, Refereed, Not invited

Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.
Okubo H; Sakoda H; Kushiyama A; Fujishiro M; Nakatsu Y; Fukushima T; Matsunaga Y; Kamata H; Asahara T; Yoshida Y; Chonan O; Iwashita M; Nishimura F; Asano T.
American Journal of Physiology - Gastrointestinal & Liver Physiology, 2013, Refereed, Not invited

Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Zhang J; Nakatsu Y; Shinjo T; Guo Y; Sakoda H; Yamamotoya T; Otani Y; Okubo H; Kushiyama A; Fujishiro M; Fukushima T; Tsuchiya Y; Kamata H; Iwashita M; Nishimura F; Katagiri H; Takahashi S; Kurihara H; Uchida T; Asano T.
Journal of Biological Chemistry, 2013, Refereed, Not invited

Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development.
Kushiyama A; Sakoda H; Oue N; Okubo M; Nakatsu Y; Ono H; Fukushima T; Kamata H; Nishimura F; Kikuchi T; Fujishiro M; Nishiyama K; Aburatani H; Kushiyama S; Iizuka M; Taki N; Encinas J; Sentani K; Ogonuki N; Ogura A; Kawazu S; Yasui W; Higashi Y; Kurihara H; Katagiri H; Asano T.
Arteriosclerosis, Thrombosis & Vascular Biology, 2013, Refereed, Not invited

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice.
Iwashita M; Nakatsu Y; Sakoda H; Fujishiro M; Kushiyama A; Fukushima T; Kumamoto S; Shinjo T; Kamata H; Nishimura F; Asano T.
Adipocyte, 2013, Refereed, Not invited

Integrator complex plays an essential role in adipose differentiation.
Otani Y; Nakatsu Y; Sakoda H; Fukushima T; Fujishiro M; Kushiyama A; Okubo H; Tsuchiya Y; Ohno H; Takahashi S; Nishimura F; Kamata H; Katagiri H; Asano T.
Biochemical & Biophysical Research Communications, 2013, Refereed, Not invited

Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model.
Nakatsu Y; Otani Y; Sakoda H; Zhang J; Guo Y; Okubo H; Kushiyama A; Fujishiro M; Kikuchi T; Fukushima T; Ohno H; Tsuchiya Y; Kamata H; Nagamachi A; Inaba T; Nishimura F; Katagiri H; Takahashi SI; Kurihara H; Uchida T; Asano T
J Biol Chem, Oct. 2012, Refereed, Not invited

DPP阻害薬が炎症性サイトカイン発現ならびにインスリンシグナルへ及ぼす影響の検討
新城 尊徳; 浅野 知一郎; 西村 英紀; 福島 俊明; 大久保 博史; 郭 榮; 岩下 未咲; 藤城 緑; 菊池 貴子
糖尿病, Apr. 2012

Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes
Misaki Iwashita; Hideyuki Sakoda; Akifumi Kushiyama; Midori Fujishiro; Haruya Ohno; Yusuke Nakatsu; Toshiaki Fukushima; Sonoko Kumamoto; Yoshihiro Tsuchiya; Takako Kikuchi; Hiroki Kurihara; Hiroshi Akazawa; Issei Komuro; Hideaki Kamata; Fusanori Nishimura; Tomoichiro Asano
American Journal of Physiology-Endocrinology and Metabolism, Feb. 2012, Refereed

Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model.
Nakatsu Y; Otani Y; Sakoda H; Zhang J; Guo Y; Okubo H; Kushiyama A; Fujishiro M; Kikuch T; Fukushima T; Ohno H; Tsuchiya Y; Kamata H; Nagamachi A; Inaba T; Nishimura F; Katagiri H; Takahashi S; Kurihara H; Uchida T; Asano T.
Journal of Biological Chemistry, 2012, Refereed, Not invited

Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages.
Kumamoto S; Kushiyama A; Nakatsu Y; Sakoda H; Fujishiro M; Iwashita M; Ohno H; Zhang J; Guo Y; Aburatani H; Kamata H; Nishimura F; Asano T.
Obesity Research & Clinical Practice, 2012, Refereed, Not invited

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8.
Kikuchi T; Zhang J; Sakoda H; Koketsu Y; Fujishiro M; Kushiyama A; Nakatsu Y; Kamata H; Inoki K; Takahashi S; Kurihara H; Hideki K; Oka Y; Asano T.
Obesity Research & Clinical Practice, 2012, Refereed, Not invited

Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development.
Kushiyama A; Okubo H; Sakoda H; Kikuchi T; Fujishiro M; Sato H; Kushiyama S; Iwashita M; Nishimura F; Fukushima T; Nakatsu Y; Kamata H; Kawazu S; Higashi Y; Kurihara H; Asano T.
Arteriosclerosis, Thrombosis & Vascular Biology, 2012, Refereed, Not invited

Association between type 1 diabetes mellitus and remitting seronegative symmetrical synovitis with pitting edema: A case report
Hideyuki Sakoda; Shizuo Ito; Hiroko Kanda; Midori Fujishiro; Jun-ichi Osuga; Kazuhisa Tsukamoto; Kohjiro Ueki; Takashi Kadowaki
Diabetes Research and Clinical Practice, Feb. 2011, Refereed

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
Nakatsu Y; Sakoda H; Kushiyama A; Zhang J; Ono H; Fujishiro M; Kikuchi T; Fukushima T; Yoneda M; Ohno H; Horike N; Kanna M; Tsuchiya Y; Kamata H; Nishimura F; Isobe T; Ogihara T; Katagiri H; Oka Y; Takahashi S; Kurihara H; Uchida T; Asano T.
Journal of Biological Chemistry, 2011, Refereed, Not invited

4F2hc stabilizes GLUT1 protein and increases glucose transport activity.
Ohno H; Nakatsu Y; Sakoda H; Kushiyama A; Ono H; Fujishiro M; Otani Y; Okubo H; Yoneda M; Fukushima T; Tsuchiya Y; Kamata H; Nishimura F; Kurihara H; Katagiri H; Oka Y; Asano T.
American Journal of Physiology - Cell Physiology, 2011, Refereed, Not invited

Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity*
Yusuke Nakatsu; Hideyuki Sakoda; Akifumi Kushiyama; Hiraku Ono; Midori Fujishiro; Nanao Horike; Masayasu Yoneda; Haruya Ohno; Yoshihiro Tsuchiya; Hideaki Kamata; Hidetoshi Tahara; Toshiaki Isobe; Fusanori Nishimura; Hideki Katagiri; Yoshitomo Oka; Toshiaki Fukushima; Shin-Ichiro Takahashi; Hiroki Kurihara; Takafumi Uchida; Tomoichiro Asano
Journal of Biological Chemistry, Oct. 2010, Refereed

Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase
Masayasu Yoneda; Ying Guo; Haruya Ono; Yusuke Nakatsu; Jun Zhang; XingLong Cui; Misaki Iwashita; Sonoko Kumamoto; Yoshihiro Tsuchiya; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Yuko Koketsu; Takako Kikuchi; Hideaki Kamata; Fusanori Nishimura; Tomoichiro Asano
Obesity Research & Clinical Practice, Jul. 2010, Refereed

Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy
Xinglong Cui; Akifumi Kushiyama; Masayasu Yoneda; Yusuke Nakatsu; Ying Guo; Jun Zhang; Haruya Ono; Machi Kanna; Hideyuki Sakoda; Hiraku Ono; Takako Kikuchi; Midori Fujishiro; Masashi Shiomi; Hideaki Kamata; Hiroki Kurihara; Masatoshi Kikuchi; Shoji Kawazu; Fusanori Nishimura; Tomoichiro Asano
Diabetes Research and Clinical Practice, Jan. 2010, Refereed

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver
Nanao Horike; Hideyuki Sakoda; Akifumi Kushiyama; Hiraku Ono; Midori Fujishiro; Hideaki Kamata; Koichi Nishiyama; Yasunobu Uchijima; Yukiko Kurihara; Hiroki Kurihara; Tomoichiro Asano
Journal of Biological Chemistry, Dec. 2008, Refereed

Long-term Forskolin Stimulation Induces AMPK Activation and Thereby Enhances Tight Junction Formation in Human Placental Trophoblast BeWo Cells
M. Egawa; H. Kamata; A. Kushiyama; H. Sakoda; M. Fujishiro; N. Horike; M. Yoneda; Y. Nakatsu; Guo Ying; Zhang Jun; Y. Tsuchiya; K. Takata; H. Kurihara; T. Asano
Placenta, Dec. 2008, Refereed

Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice
Yuko Koketsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Yasushi Fukushima; Hiraku Ono; Motonobu Anai; Takako Kikuchi; Takeshi Fukuda; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
American Journal of Physiology-Endocrinology and Metabolism, Apr. 2008, Refereed

Regulation of gut-derived resistin-like molecule β expression by nutrients
Junko Fujio; Akifumi Kushiyama; Hideyuki Sakoda; Midori Fujishiro; Takehide Ogihara; Yasushi Fukushima; Motonobu Anai; Nanao Horike; Hideaki Kamata; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Diabetes Research and Clinical Practice, Jan. 2008, Refereed

Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways
Hiraku Ono; Hideyuki Sakoda; Midori Fujishiro; Motonobu Anai; Akifumi Kushiyama; Yasushi Fukushima; Hideki Katagiri; Takehide Ogihara; Yoshitomo Oka; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
American Journal of Physiology-Cell Physiology, Nov. 2007, Refereed

Role of Phosphatidylinositol 3-Kinase Activation on Insulin Action and Its Alteration in Diabetic Conditions
Tomoichiro Asano; Midori Fujishiro; Akifumi Kushiyama; Yusuke Nakatsu; Masayasu Yoneda; Hideaki Kamata; Hideyuki Sakoda
Biological and Pharmaceutical Bulletin, 2007, Not refereed

Physiological Significance of Resistin and Resistin-Like Molecules in the Inflammatory Process and Insulin Resistance
Asano T; Sakosda H; Fujishiro M; Anai M; Kushiyama A; Horike N; Kamata H; Ogihara T; Kurihara H; Uchijima Y
Current Diabetes Reviews, Nov. 2006, Refereed

Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression
Amelia Y.I. Viana; Hideyuki Sakoda; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Akifumi Kushiyama; Yasushi Fukushima; Yuzo Sato; Yoshiharu Oshida; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Diabetes Research and Clinical Practice, Aug. 2006, Refereed

Resistin-like Molecule β Activates MAPKs, Suppresses Insulin Signaling in Hepatocytes, and Induces Diabetes, Hyperlipidemia, and Fatty Liver in Transgenic Mice on a High Fat Diet
Akifumi Kushiyama; Nobuhiro Shojima; Takehide Ogihara; Kouichi Inukai; Hideyuki Sakoda; Midori Fujishiro; Yasushi Fukushima; Motonobu Anai; Hiraku Ono; Nanao Horike; Amelia Y.I. Viana; Yasunobu Uchijima; Koichi Nishiyama; Tatsuo Shimosawa; Toshiro Fujita; Hideki Katagiri; Yoshitomo Oka; Hiroki Kurihara; Tomoichiro Asano
Journal of Biological Chemistry, Dec. 2005, Refereed

Glycogen debranching enzyme association with β-subunit regulates AMP-activated protein kinase activity
Hideyuki Sakoda; Midori Fujishiro; Junko Fujio; Nobuhiro Shojima; Takehide Ogihara; Akifumi Kushiyama; Yasushi Fukushima; Motonobu Anai; Hiraku Ono; Masatoshi Kikuchi; Nanao Horike; Amelia Y. I. Viana; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
American Journal of Physiology-Endocrinology and Metabolism, Sep. 2005, Refereed

A Novel Protein Kinase B (PKB)/AKT-binding Protein Enhances PKB Kinase Activity and Regulates DNA Synthesis
Motonobu Anai; Nobuhiro Shojima; Hideki Katagiri; Takehide Ogihara; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Yasushi Fukushima; Nanao Horike; Amelia Viana; Masatoshi Kikuchi; Noriko Noguchi; Shinichiro Takahashi; Kuniaki Takata; Yoshitomo Oka; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Journal of Biological Chemistry, May 2005, Refereed

Serum concentrations of resistin-like molecules β and γ are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow
N. Shojima; T. Ogihara; K. Inukai; M. Fujishiro; H. Sakoda; A. Kushiyama; H. Katagiri; M. Anai; H. Ono; Y. Fukushima; N. Horike; A. Y. I. Viana; Y. Uchijima; H. Kurihara; T. Asano
Diabetologia, Apr. 2005, Refereed

Alterations in Mitogen-Activated Protein Kinase Kinase and Extracellular Regulated Kinase Signaling in Theca Cells Contribute to Excessive Androgen Production in Polycystic Ovary Syndrome
Velen L. Nelson-Degrave; Jessica K. Wickenheisser; Karen L. Hendricks; Tomoichiro Asano; Midori Fujishiro; Richard S. Legro; Scot R. Kimball; Jerome F. Strauss; Jan M. McAllister
Molecular Endocrinology, Feb. 2005, Refereed

Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa
Yasushi Fukushima; Toshimitsu Matsui; Toshihito Saitoh; Masao Ichinose; Keisuke Tateishi; Takayuki Shindo; Midori Fujishiro; Hideyuki Sakoda; Nobuhiro Shojima; Akifumi Kushiyama; Satoru Fukuda; Motonobu Anai; Hiraku Ono; Masashi Oka; Yasuhito Shimizu; Hiroki Kurihara; Ryozo Nagai; Takashi Ishikawa; Tomoichiro Asano; Masao Omata
European Journal of Pharmacology, Oct. 2004, Refereed

Glucose Transporter and Na+ / glucose Cotransporter as Molecular Targets of Anti-Diabetic Drugs
Tomoichiro Asano; Takehide Ogihara; Hideki Katagiri; Hideyuki Sakoda; Hiraku Ono; Midori Fujishiro; Motonobu Anai; Hiroki Kurihara; Yasunobu Uchijima
Current Medicinal Chemistry, Oct. 2004, Refereed

Oxidative stress induces insulin resistance by activating the nuclear factor-?B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase
T. Ogihara; T. Asano; H. Katagiri; H. Sakoda; M. Anai; N. Shojima; H. Ono; M. Fujishiro; A. Kushiyama; Y. Fukushima; M. Kikuchi; N. Noguchi; H. Aburatani; Y. Gotoh; I. Komuro; T. Fujita
Diabetologia, May 2004, Refereed

Molecular mechanisms of insulin resistance associated with hypertension and oxidative stress.
Ogihara T; Ssakoda H; Katagiri H; Anai M; Shojima N; Kushiyama A; Fujishiro M; Ono H; Kikuchi M; Fujita T; Asano T
Recent Research Developments in Biophysics and Biochemistry, 2004, Not refereed

SGLT as a therapeutic target.
Asano T; Anai M; Sakoda H; Fujishiro M; Ono H; Kurihara H; Uchijima Y
Drugs of the Future, 2004

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
Hiraku Ono; Hitoshi Shimano; Hideki Katagiri; Naoya Yahagi; Hideyuki Sakoda; Yukiko Onishi; Motonobu Anai; Takehide Ogihara; Midori Fujishiro; Amelia Y.I. Viana; Yasushi Fukushima; Miho Abe; Nobuhiro Shojima; Masatoshi Kikuchi; Nobuhiro Yamada; Yoshitomo Oka; Tomoichiro Asano
Diabetes, Dec. 2003, Refereed

Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity
Hideyuki Sakoda; Yukiko Gotoh; Hideki Katagiri; Mineo Kurokawa; Hiraku Ono; Yukiko Onishi; Motonobu Anai; Takehide Ogihara; Midori Fujishiro; Yasushi Fukushima; Miho Abe; Nobuhiro Shojima; Masatoshi Kikuchi; Yoshitomo Oka; Hisamaru Hirai; Tomoichiro Asano
Journal of Biological Chemistry, Jul. 2003, Refereed

Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice
Yasushi Fukushima; Takayuki Shindo; Motonobu Anai; Toshihito Saitoh; Yuhui Wang; Midori Fujishiro; Yoshio Ohashi; Takehide Ogihara; Kouichi Inukai; Hiraku Ono; Hideyuki Sakoda; Yukiko Kurihara; Miho Honda; Nobuhiro Shojima; Harumi Fukushima; Yukiko Haraikawa-Onishi; Hideki Katagiri; Yasuhito Shimizu; Masao Ichinose; Takashi Ishikawa; Masao Omata; Ryozo Nagai; Hiroki Kurihara; Tomoichiro Asano
European Journal of Pharmacology, May 2003, Refereed

A case showing an association between type 1 diabetes mellitus and Kabuki syndrome
Midori Fujishiro; Takehide Ogihara; Katsunori Tsukuda; Nobuhiro Shojima; Yasushi Fukushima; Satoshi Kimura; Yoshitomo Oka; Tomoichiro Asano
Diabetes Research and Clinical Practice, Apr. 2003, Refereed
Lead

Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation
Yukiko Onishi; Miho Honda; Takehide Ogihara; Hideyuki Sakoda; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Nobuhiro Shojima; Yasushi Fukushima; Kouichi Inukai; Hideki Katagiri; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Biochemical and Biophysical Research Communications, Apr. 2003, Refereed

Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes
M Fujishiro; Y Gotoh; H Katagiri; H Sakoda; T Ogihara; M Anai; Y Onishi; H Ono; W Abe; N Shojima; Y Fukushima; M Kikuchi; Y Oka; T Asano
MOLECULAR ENDOCRINOLOGY, Mar. 2003, Refereed, Not invited
Lead

Extremely Early Onset of Ranitidine Action on Human Histamine H₂ Receptors Expressed in HEK293 Cells
Yasushi Fukushima; Takashi Ishikawa; Toshihito Saitoh; Keisuke Tateishi; Takehide Ogihara; Midori Fujishiro; Nobuhiro Shojima; Miho Honda; Akifumi Kushiyama; Motonobu Anai; Hideyuki Sakoda; Hiraku Ono; Yukiko Onishi; Hiroko Otsuka; Hideki Katagiri; Ryozo Nagai; Masao Omata; Tomoichiro Asano
Digestion, 2003, Refereed

The roles of three mitogen- activated protein kinases in insulin resistance.
Fujishiro M; Ogihara T; Katagiri H; and Asano T.
Recent Research Developments in Physiology, 2003, Not refereed, Invited
Lead

Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling
Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Yuko Chiba; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Hideki Katagiri; Yasushi Fukushima; Masatoshi Kikuchi; Noriko Noguchi; Hiroyuki Aburatani; Issei Komuro; Toshiro Fujita
Hypertension, Dec. 2002, Refereed

Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
Haiyan Song; Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; Hitoshi Shimano; Nobuhiro Yamada; Yoshitomo Oka; Tomoichiro Asano
Biochemical and Biophysical Research Communications, Nov. 2002, Refereed

High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl Salt-Sensitive Rats
Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Toshiro Fujita
Hypertension, Jul. 2002, Refereed

Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells
Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Diabetes, Jun. 2002, Refereed

Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
Hideyuki Sakoda; Takehide Ogihara; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Yukiko Onishi; Hideki Katagiri; Miho Abe; Yasushi Fukushima; Nobuhiro Shojima; Kouichi Inukai; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
American Journal of Physiology-Endocrinology and Metabolism, Jun. 2002, Refereed

Regulation of Phosphoinositide Metabolism, Akt Phosphorylation, and Glucose Transport by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) in 3T3-L1 Adipocytes
Hiraku Ono; Hideki Katagiri; Makoto Funaki; Motonobu Anai; Kouichi Inukai; Yasushi Fukushima; Hideyuki Sakoda; Takehide Ogihara; Yukiko Onishi; Midori Fujishiro; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Molecular Endocrinology, Aug. 2001, Refereed

Palmitoylation of the canine histamine H2 receptor occurs at Cys305 and is important for cell surface targeting
Yasushi Fukushima; Toshihito Saitoh; Motonobu Anai; Takehide Ogihara; Kouichi Inukai; Makoto Funaki; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Takashi Ishikawa; Kuniaki Takata; Ryozo Nagai; Masao Omata; Tomoichiro Asano
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Jun. 2001, Refereed

MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression
M Fujishiro; Y Gotoh; H Katagiri; H Sakoda; T Ogihara; M Anai; Y Onishi; H Ono; M Funaki; K Inukai; Y Fukushima; M Kikuchi; Y Oka; T Asano
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2001, Refereed, Not invited
Lead

Insulin Resistance With Enhanced Insulin Signaling in High-Salt Diet–Fed Rats
Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Yuko Chiba; Nobuo Sekine; Hideyuki Sakoda; Motonobu Anai; Yukiko Onishi; Midori Fujishiro; Hiraku Ono; Nobuhiro Shojima; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; Toshiro Fujita
Diabetes, Mar. 2001, Refereed

Five isoforms of the phosphatidylinositol 3‐kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
Kouichi Inukai; Makoto Funaki; Motonobu Anai; Takehide Ogihara; Hideki Katagiri; Yasushi Fukushima; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Miho Abe; Yoshitomo Oka; Masatoshi Kikuchi; Tomoichiro Asano
FEBS Letters, Feb. 2001, Refereed

G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure
Y Fukushima; T Saitoh; M Anai; K Tsukuda; Y Onishi; H Sakoda; K Inukai; T Ogihara; M Funaki; H Ono; M Fujishiro; T Ishikawa; R Nagai; M Omata; T Asano
The Pharmacogenomics Journal, Jan. 2001, Refereed

Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
Sakoda H; Ogihara T; Anai M; Funaki M; Inukai K; Katagiri H; Fukushima Y; Onishi Y; Ono H; Fujishiro M; Kikuchi M; Oka Y; Asano T
Diabetes, Oct. 2000, Refereed

Clinical relevance of heteroplasmic concentration of mitochondrial A3243G mutation in leucocytes
Asano T; Tsukuda K; Katagiri H; Onishi Y; Sakoda H; Ono H; Ogihara T; Funaki M; Anai M; Inukai K; Fujishiro M; Fukushima Y; Yamasoba T; Oka T; Kikuchi M; Oka Y
Diabetologia, Dec. 1999, Refereed

慢性腎臓病合併2型糖尿病患者における腎機能低下に関連する因子の探索
田久保 正洋; 齊藤 一樹; 青木 倫子; 野田 日菜子; 三枝 太郎; 藤城 緑; 石原 寿光; 渡邉 健太郎
糖尿病, Apr. 2024

腎盂癌治療に伴う免疫関連副作用による甲状腺機能低下後に高血糖を生じた2型糖尿病
武内美咲; 池田迅; 大下菜月; 津谷恒太; 小川克彦; 鈴木裕; 石原寿光; 藤城緑; 武内美咲; 池田迅; 大下菜月; 津谷恒太; 小川克彦; 鈴木裕; 藤城緑
糖尿病(Web), 2023

リラグルチド導入直後に胆嚢炎を発症した肝硬変合併糖尿病の1例
西岡秀典; 武内美咲; 池田迅; 引地麻梨; 幸田拳征; 田中良磨; 小川克彦; 鈴木裕; 石原寿光; 藤城緑; 西岡秀典; 武内美咲; 池田迅; 引地麻梨; 幸田拳征; 田中良磨; 小川克彦; 鈴木裕; 藤城緑
糖尿病(Web), 2023

骨格筋TFGの肥満形成および神経筋接合部の維持における役割
山本屋 武; 大畠 侑乃; 赤坂 保行; 神名 麻智; 中津 祐介; 迫田 秀之; 藤城 緑; 櫛山 暁史; 浅野 知一郎
糖尿病, Apr. 2022

Trk-fused gene(TFG)の脂肪細胞における代謝制御機構の解明
山本屋 武; 長谷井 竣; 中津 祐介; 大畠 侑乃; 迫田 秀之; 藤城 緑; 櫛山 暁史; 浅野 知一郎
糖尿病, May 2021

Trk-fused gene(TFG)の脂肪細胞における代謝制御機構の解明
山本屋 武; 長谷井 竣; 中津 祐介; 大畠 侑乃; 迫田 秀之; 藤城 緑; 櫛山 暁史; 浅野 知一郎
糖尿病, May 2021

脂肪細胞のTrk-fused gene(TFG)はPPARγ発現量およびミトコンドリア機能を調節し、adipose expansionに重要である
山本屋 武; 長谷井 竣; 中津 祐介; 迫田 秀之; 藤城 緑; 櫛山 暁史; 浅野 知一郎
糖尿病, Aug. 2020

Trk-fused gene(TFG)の骨格筋機能および肥満発症における役割
長谷井 竣; 山本屋 武; 中津 祐介; 迫田 秀之; 藤城 緑; 櫛山 暁史; 浅野 知一郎
糖尿病, Aug. 2020

脂肪細胞のTrk-fused gene(TFG)による代謝制御機構の解明
山本屋 武; 長谷井 竣; 中津 祐介; 井上 賢紀; 迫田 秀之; 藤城 緑; 櫛山 暁史; 浅野 知一郎
糖尿病, Apr. 2019

認知症超高齢者に発症した後天性血友病の1例
久志本優; 久志本優; 小川克彦; 河野弦太; 池田迅; 池田迅; 藤城緑; 鈴木裕; 鈴木裕
日本プライマリ・ケア連合学会学術大会(Web), 2019

糖尿病性ケトアシドーシス昏睡で入院加療後,アプリを用いた自己管理徹底で,肥満症と糖尿病が改善した一例
池田迅; 藤城緑; 藤城緑; 久志本優; 齋藤一樹; 小川克彦; 石原寿光; 鈴木裕
日本プライマリ・ケア連合学会学術大会(Web), 2019

Mechanism Mediated by S6 Kinase Resulting in both Sufficient Glucose Metabolism Improvement and Insufficient Weight Loss by Glucose Excretion against Fat Load
Takako Kikuchi; Akifumi Kushiyama; Midori Fujishiro; Hideyuki Sakoda; Tomoichiro Asano; Yasuhiko Iwamoto
DIABETES, Jul. 2018

Role of Xanthine Oxidoreductase from Mesenchymal Cells in Retinal Inflammation after Pericyte Breakdown
Akifumi Kushiyama; Takako Kikuchi; Hiroki Yamazaki; Takeshi Yamamotoya; Hideyuki Sakoda; Midori Fujishiro; Yusuke Nakatsu; Akiyoshi Uemura; Takashi Shirakura; Tomoichiro Asano; Yasuhiko Iwamoto
DIABETES, Jul. 2018

The Prevalence of Gastrointestinal Symptoms Depends on Disease Duration and Gastrointestinal Tract Region in Patients with Type 2 Diabetes
Midori Fujishiro; Akifumi Kushiyama; Hiroki Yamazaki; Takeshi Yamamotoya; Takako Kikuchi; Hideyuki Sakoda; Ryo Suzuki; Takashi Kadowaki
DIABETES, Jul. 2018

SGLT2 Inhibitor Luseogliflozin Improves Nonalcoholic Hepatosteatosis in a Rodent Model
Midori Fujishiro; Yusuke Nakatsu; Hideyuki Sakoda; Akifumi Kushiyama; Tomoichiro Asano
DIABETES, Jun. 2015, Not refereed, Not invited

The Xanthine Oxidase Inhibitor Febuxostat Suppresses Nonalcoholic Steatohepatitis Development due to High-Fat Diet Containing Trans Fatty Acid
Yusuke Nakatsu; Akifumi Kushiyama; Hideyuki Sakoda; Midori Fujishiro; Aya Katasako; Keiichi Mori; Yasuka Matsunaga; Tomoichiro Asano
DIABETES, Jun. 2015, Not refereed, Not invited

キサンチンオキシターゼ阻害剤FebuxostatによるNASH改善作用の検討
松永 泰花; 中津 祐介; 迫田 秀之; 櫛山 暁史; 藤城 緑; 山本屋 武; 鎌田 英明; 新城 尊徳; 岩下 未咲; 西村 英紀; 小野 啓; 浅野 知一郎
糖尿病, Apr. 2015

Hepatic Overexpression of Rictor Improves Fatty Liver in Mice Fed with High-Fat Diet
Takako Kikuchi; Hideyuki Sakoda; Akifumi Kushiyama; Midori Fuji-Shiro; Sunao Kaneko; Takeshi Yamamotoya; Hiroki Yamazaki; Shoji Kawazu; Tomoichiro Asano
DIABETES, Jun. 2014, Not refereed, Not invited

Involvement of Resistin-like Molecule beta in the Development of Nonalcoholic Steatohepatitis
Akifumi Kushiyama; Hirofumi Okubo; Yusuke Nakatsu; Hideyuki Sakoda; Midori Fujishiro; Toshiaki Fukushima; Shin-Iciro Takahashi; Tomoichiro Asano
DIABETES, Jun. 2014, Not refereed, Not invited

The Role of Linear Ubiquitin Chain Assembly Complex (LUBAC) and Its Components in Insulin Signal Transduction
Takeshi Yamamotoya; Hideyuki Sakoda; Midori Fujishiro; Sunao Kaneko; Hiroki Yamazaki; Takako Kikuchi; Akifumi Kushiyama; Tomoichiro Asano
DIABETES, Jun. 2014, Not refereed, Not invited

DPP-4 Inhibitor Anagliptin Exerts Anti-inflammatory Effects on Macrophages, Adipocytes, and Mouse Liver by Suppressing LPS-Induced Nf-kappa B Activation
Takanori Shinjo; Misaki Iwashita; Hideyuki Sakoda; Midori Fujishiro; Takeshi Yamamotoya; Akifumi Kushiyama; Fusanori Nishimura; Tomoichiro Asano
DIABETES, Jun. 2014, Not refereed, Not invited

Pin1 Reduces AMPK Phosphorylation and Thereby Contributes to the Impaired Mitochondrial Activity and Lipid Accumulation in the Muscle
Yusuke Nakatsu; Misaki Iwashita; Yasuka Matsunaga; Toshiaki Fuku Shima; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Takafumi Uchida; Tomoichiro Asano
DIABETES, Jun. 2014, Not refereed, Not invited

ストレプトゾトシン処理後の膵ランゲルハンス島に対するDPP4阻害薬SK-0403の改善作用
岩下 未咲; 大久保 博史; 迫田 秀之; 藤城 緑; 櫛山 暁史; 中津 祐介; 福嶋 俊明; 新城 尊徳; 西村 英紀; 浅野 知一郎
糖尿病, Apr. 2013

DPP4阻害薬SK-0403はマクロファージ共培養における脂肪細胞の炎症性遺伝子の発現を抑制する
新城 尊徳; 岩下 未咲; 中津 祐介; 迫田 秀之; 藤城 緑; 櫛山 暁史; 菊池 貴子; 西村 英紀; 浅野 知一郎
糖尿病, Apr. 2013

Par14 Associates With IRS-1, Thereby Enhancing Insulin-Induced IRS-1 Phosphorylation and Metabolic Actions
Jun Zhang; Yusuke Nakatsu; Tsuyoshi Yamamotoya; Ying Guo; Midori Fujishiro; Akifumi Kushiyama; Hideyuki Sakoda; Tomoichiro Asano
DIABETES, Jun. 2012, Not refereed, Not invited

動脈硬化を進展させるレジスチン様分子βの作用機構(Mechanism of atherosclerosis development facilitated by resistin like molecule beta)
櫛山 暁史; 迫田 秀之; 菊池 貴子; 藤城 緑; 纐纈 優子; 櫛山 櫻; 佐藤 博和; 西山 功一; 栗原 裕基; 大久保 博史; 中津 祐介; 河津 捷二; 浅野 知一郎
日本生化学会大会プログラム・講演要旨集, Sep. 2011

Hepatic LST8 Overexpression in C57BL6/j Mice Improve Glucose Tolerance, Plasma Lipid Profile and Also Decrease Intrahepatic Fat
Takako Kikuchi; Hideyuki Sakoda; Midori Fujishiro; Yuko Koketsu; Akifumi Kushiyama; Shoji Kawazu; Tomoichiro Asano
DIABETES, Jul. 2011

キサンチンオキシダーゼ経路のマクロファージ泡沫化と動脈硬化への関与
櫛山 暁史; 菊池 貴子; 迫田 秀之; 藤城 緑; 纐纈 優子; 大西 由希子; 佃 克則; 櫛山 櫻; 佐藤 博和; 西山 功一; 栗原 裕基; 田中 健太郎; 大久保 博史; 岩下 美咲; 熊本 園子; 大野 晴也; 中津 祐介; 河津 捷二; 浅野 知一郎
糖尿病, Apr. 2011

非アルコール性脂肪性肝炎(NASH)の発症におけるプロリン異性化酵素Pin1の役割
迫田 秀之; 中津 祐介; 大久保 博史; 大野 晴也; 櫛山 暁史; 福嶋 俊明; 藤城 緑; 菊池 貴子; 門脇 孝; 浅野 知一郎
糖尿病, Apr. 2011

レジスチン関連蛋白β(RELMβ)の非アルコール性脂肪性肝炎(NASH)の発症における役割
大久保 博史; 中津 祐介; 大野 晴也; 櫛山 暁史; 福嶋 俊明; 迫田 秀之; 藤城 緑; 西村 英紀; 浅野 知一郎
糖尿病, Apr. 2011

Valsartan Suppresses Inflammatory Response of LPS-Induced Activated Macrophages and Thereby Improves Adipose Insulin Resistance
Misaki Iwashita; Sonoko Kumamoto; Akifumi Kushiyama; Yusuke Nakatsu; Yoshihiro Tsuchiya; Hideyuki Sakoda; Midori Fujishiro; Yuichiro Otani; Takako Kikuchi; Fusanori Nishimura; Hideaki Kamata; Tomoichiro Asano
DIABETES, Jun. 2010, Not refereed, Not invited

Macrophage Foam Cell Formation Is Augmented in Serum from Patients with Diabetic Angiopathy
Midori Fujishiro; Xinglong Cui; Akifumi Kushiyama; Yusuke Nakatsu; Sonoko Kumamoto; Ying Gun; Jun Zhang; Hideyuki Sakoda; Fusanori Nishimura; Tomoichiro Asano
DIABETES, Jun. 2010, Not refereed, Not invited

LST8 Level Controls Basal p70 S6 Kinase and Akt Phosphorylations, and mTORC1 and mTORC2 Negatively Regulate Each Other by Competing for Association with LST8
Takako Kikuchi; Hideyuki Sakoda; Akifumi Kushiyama; Midori Fujishiro; Yuko Koketsu; Hiraku Ono; Shoji Kawazu; Tomoichiro Asano
DIABETES, Jun. 2010, Not refereed, Not invited

Involvement of Xanthine Oxidase Pathway in Pathogenesis of Macrophage Activation
Akifumi Kushiyama; Yusuke Nakatsu; Xinglong Cui; Hideyuki Sakoda; Midori Fujishiro; Haruya Ohno; Misaki Iwashita; Machi Kanna; Fusanori Nishimura; Tomoichiro Asano
DIABETES, Jun. 2010, Not refereed, Not invited

Peptidyl Prolyl Cis/Trans Isomerase Pin1 Interacts with CRTC2 and Regulates Gluconeogenesis
Yusuke Nakatsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Takako Kikuchi; Fusanori Nishimura; Hideaki Kamata; Tomoichiro Asano
DIABETES, Jun. 2010, Not refereed, Not invited

アロプリノールはマクロファージの泡沫化及びApoEノックアウトマウスにおける動脈硬化の進行を抑制する
中道 淳仁; 中津 祐介; 張 君; 崔 興龍; 岩下 未咲; 熊本 園子; 太谷 裕一郎; 藤城 緑; 迫田 秀之; 櫛山 暁史; 浅野 知一郎
糖尿病, Apr. 2010

活性化マクロファージによる脂肪・肝のインスリン抵抗生誘導とARBによる抵抗性改善作用の機序に関する網羅的解析
熊本 園子; 岩下 未咲; 中津 祐介; 櫛山 暁史; 迫田 秀之; 藤城 緑; 神名 麻智; 郭 榮; 菊池 貴子; 西村 英紀; 浅野 知一郎
糖尿病, Apr. 2010

LPSによる脂肪組織インスリン抵抗性へのマクロファージの関与およびARBによるインスリン抵抗性改善作用の機序
岩下 未咲; 熊本 園子; 迫田 秀之; 櫛山 暁史; 藤城 緑; 中津 祐介; 張 君; 菊池 貴子; 神名 麻智; 西村 英紀; 浅野 知一郎
糖尿病, Apr. 2010

GLUT1と相互作用を有する膜タンパク質4F2hcの同定と糖取り込みに与える影響
大野 晴也; 中津 祐介; 大久保 博史; 大谷 祐一郎; 崔 興龍; 張 君; 郭 瑩; 迫田 秀之; 藤城 緑; 櫛山 暁史; 土谷 佳弘; 鎌田 英明; 浅野 知一郎
日本生化学会大会プログラム・講演要旨集, Sep. 2009

Impaired mT0Rc1 Stability Results in LST8 Transfer to mT0Rc2 and the Enhancement of Akt Phosphorylation in HepG2 Cells
Takako Kikuchi; Hideyuki Sakoda; Yuko Koketsu; Midori Fujishiro; Akifumi Kushiyama; Takeshi Fukuda; Hiraku Ono; Tomoichiro Asano
DIABETES, Jun. 2009, Not refereed, Not invited

Hepatic LKB1-AMPK Pathway Is Activated by Both Insulin and Energy Deficiency, and Is Regulated Differently between High-Fat Diet Fed and Ob/ob Mice
Masayasu Yoneda; Haruya Ohno; Yusuke Nakatsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Hideaki Kamata; Fusanori Nishimura; Tomoichiro Asano
DIABETES, Jun. 2009, Not refereed, Not invited

Pin1 Binds to IRS-1, and Functions as a Nutrient-Sensing Enhancer of Insulin Signaling
Yusuke Nakatsu; Hideyuki Sakoda; Akifumi Kushiyama; Midori Fujishiro; Masayasu Yoneda; Haruya Ohno; Hideaki Kamata; Takafumi Uchida; Tomoichiro Asano
DIABETES, Jun. 2009, Not refereed, Not invited

GLUT1と相互作用を有する膜タンパク質4F2hcの同定と機能の解析
大野 晴也; 米田 真康; 中津 祐介; 大谷 祐一郎; 崔 興龍; 張 君; 郭 瑩; 櫛山 暁史; 迫田 秀之; 藤城 緑; 浅野 知一郎
糖尿病, Apr. 2009

Enhancement of Akt phosphorylation in HepG2 by overexpressing C terminally deleted Raptor
Takako Kikuchi; Hideyuki Sakoda; Yuko Koketsu; Midori Fujishiro; Akifumi Kushiyama; Takeshi Fukuda; Hiraku Ono; Tomoichiro Asano
DIABETES, Jun. 2008, Not refereed, Not invited

Functionally distinct roles of each member of the resistin family in insulin resistance and atherosclerosis
Akifumi Kushiyama; Hideyuki Sakoda; Midori Fujishiro; Haruya Ohno; Masayasu Yoneda; Yusuke Nakatsu; Hideaki Kamata; Masatoshi Kikuchi; Tomoichiro Asano
DIABETES, Jun. 2008, Not refereed, Not invited

グラルギンで血糖コントロール良好となった、疾患感受性HLAを有する同胞間若年発症1型糖尿病の姉妹例
青木 龍; 藤城 緑; 根本 充; 中川 迅; 迫田 秀之; 大橋 健; 原 一雄; 塚本 和久; 植木 浩二郎; 門脇 孝
日本内科学会関東地方会, May 2008, Not refereed, Not invited

Hepatic overexpression of dominant negative form of mTOR enhances Akt phosphorylation and restores insulin resistance in K/KAy mice
Yuko Koketsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Takako Kikuchi; Takeshi Fukuda; Tomoichiro Asano
DIABETES, Jun. 2007, Not refereed, Not invited

Insulin resistance-inducible RELM (Resistin like molecule) beta also involves atherosclerosis with directly affecting endothelial function
Akifumi Kushiyama; Hideyuki Sakoda; Midori Fujishiro; Motonobu Anai; Kouichi Inukai; Takehide Ogihara; Masatoshi Kikuchi; Tomoichiro Asano
DIABETES, Jun. 2007, Not refereed, Not invited

Akt結合タンパクAPEの発現低下はAkt活性を低下させ細胞増殖を抑制する
穴井 元暢; 浅野 知一郎; 柴田 健一; 小野 啓; 大西 由希子; 佃 克則; 迫田 秀之; 藤城 緑; 庄嶋 伸浩; 菊池 方利
糖尿病, Apr. 2005

Elevated serum resistin-like molecules (RELMs) concentrations in insulin resistant and transgenic mice (TG mice) suggest involvement of RELMs in pathogensis of diabetes and hyperglycemia
A Kushiyama; N Shojima; T Ogihara; K Inukai; H Sakoda; M Fujishiro; N Horike; Y Koketsu; T Asano
DIABETES, 2005, Not refereed, Not invited

ミトコンドリア遺伝子異常による糖尿病剖検例における各臓器の遺伝子異常のヘテロプラスミーの検討
小野 啓; 浅野 知一郎; 佃 克則; 犬飼 浩一; 大西 由希子; 藤城 緑; 岡田 光正; 能登 洋; 磯尾 直之; 田村 嘉章
糖尿病, Oct. 1999

ミトコンドリア遺伝子異常による糖尿病剖検例での各臓器の異常遺伝子のヘテロプラスミーの検討
浅野 知一郎; 佃 克則; 犬飼 浩一; 大西 由希子; 小野 啓; 藤城 緑; 矢崎 義雄
日本内科学会雑誌, Feb. 1999

肥満2型糖尿病のインスリン分泌および作用障害におけるXORの役割の解明
日本学術振興会, 科学研究費助成事業, 01 Apr. 2020 - 31 Mar. 2023
藤城 緑; 山名 碧

Elucidation of insulin secretory mechanisms through large scale generation of genetically-modified insulin secreting cells and omics analysis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2017 - 31 Mar. 2020
ISHIHARA Hisamitsu

Roles of Pin1 and PAR 14 on the metabolic regulations
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2014 - 31 Mar. 2017
Asano Tomoichiro; SAKODA HIDEYUKI; FUJISHIRO MIDORI; HONDA HIROAKI

Roles of trk-fused gene product protein
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2014 - 31 Mar. 2016
Asano Tomoichiro; NAKATSU YUSUKE; FUKUSHIMA TOSHIAKI; SAKODA HIDEYUKI; FUJISHIRO MIDORI; HONDA HIROAKI

Elucidation of mechanisms by which exercise improves inflammation induced by type 2 diabetes
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2015
FUJISHIRO Midori

Investigation of the role of insulin signaling molecules on development of hepatocytes into hepatocytes with fatty changes
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2010 - 2011
FUJISHIRO Midori

Clarification of the role of annexin on glucose transport
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2008 - 2009
FUJISHIRO Midori

mTOR/Raptor、Rictorを介した代謝調節とインスリン感受性への関与
日本学術振興会, 科学研究費助成事業, 2006 - 2007
藤城 緑

Elucidation of the molecular mechanisms underlying metabolic disorders using protemomics analysis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2006 - 2007
ASANO Tomoichiro; SAKODA Hideyuki; FUJISHIRO Midori; UCHIJIMA Yasunobu

小胞構成蛋白の網羅的解析による糖輸送担体の制御機構および糖尿病における障害の解明
日本学術振興会, 科学研究費助成事業, 2005 - 2005
浅野 知一郎; 内島 泰信; 迫田 秀之; 藤城 緑; 庄嶋 伸浩; 櫛山 暁史

プロテオーム解析によるインスリン感受性調節機構の解明と新規治療ターゲットの発見
日本学術振興会, 科学研究費助成事業, 2005 - 2005
浅野 知一郎; 栗原 裕基; 栗原 由紀子; 内島 泰信; 藤城 緑; 市村 徹

Elucidation of the molecular mechanisms underlying insulin and exercise-induced effects on metabolism and vascular cells
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2004 - 2005
ASANO Tomoichiro; TSUKUDA Katsunori; FUJISHIRO Midori; ABE Miho; SHOJIMA Nobuhiro; KUSHIYAMA Akifumi