Aizawa Shihoko
| Department of Medicine | Professor |
Researcher Information
Field Of Study
Career
- Apr. 2024 - Present
Nihon University School of Medicine, Department of Pathology and Microbiology, Department of Microbiology, Professor - Dec. 2014 - Mar. 2024
日本大学医学部病態病理学系微生物学分野, 准教授 - Aug. 2012 - Nov. 2014
日本大学医学部病態病理学系微生物学分野, 助教 - Apr. 2008 - Jul. 2012
日本大学医学部病態病理学系微生物学分野, 助手 - Apr. 2002 - Mar. 2010
国立感染症研究所, 協力研究員 - May 2003 - Jun. 2004
社会保険横浜中央病院産婦人科 - May 2002 - Apr. 2003
日本大学付属板橋病院産婦人科
Research activity information
Award
- Japan Society of Obstetrics and Gynecology, JSOG Congress Award
★SARS-CoV-2 infects human trophoblasts but proliferate limitedly., Japan society
Shihoko Komine-Aizawa - 2021
日本産科婦人科学会, Best Reviewer's Award 2021 - 日本産科婦人科学会, Best Reviewer's Award 2014
Japan society - 日本産科婦人科学会, Best Reviewer's Award 2009
- 日本生殖免疫学会 学会賞
妊娠カニクイザルに接種したHIV/SIVキメラウイルスの動態, Japan society
Paper
- ★Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against Mycobacterium kansasii
Shihoko Komine-Aizawa; Satoru Mizuno; Kazuhiro Matsuo; Takahiro Namiki; Satoshi Hayakawa and Mitsuo Honda
Vaccines, Nov. 2021, Refereed, Not invited
Lead - Precautionary findings on the utilization of FilmArray® to detect human astroviruses in fecal and sewage samples
Jonghyun Bae; Chika Takano; Sheikh Ariful Hoque; Hiroyuki Saito; Wakako Akino; Shuichi Nishimura; Yuko Onda; Shoko Okitsu; Satoshi Hayakawa; Shihoko Komine-Aizawa; Hiroshi Ushijima
Journal of Infection and Chemotherapy, Dec. 2024 - Epidemiology and molecular evolution of GI.1 sapovirus in the recent era.
Sheikh A Hoque; Yuki Akari; Pattara Khamrin; Tung Phan; Yuko Onda; Shoko Okitsu; Satoshi Komoto; Satoshi Hayakawa; Shihoko Komine-Aizawa; Yoshikazu Yuki; Hiroshi Kiyono; Hiroshi Ushijima
Journal of medical virology, Sep. 2024 - Comparison of adverse events following the second/third dose of BNT162b2 in a medical institute in Japan
Takahiro Namiki; Kazuhide Takada; Satoshi Hayakawa; Shihoko Komine-Aizawa
Heliyon, Jul. 2024 - SARS-CoV-2 detection in pediatric dental clinic wastewater reflects the number of local COVID-19 cases in children under 10 years old
Dai Kanamori; Jun Sakai; Takahiro Iijima; Yuka Oono; Bikash Malla; Eiji Haramoto; Satoshi Hayakawa; Shihoko Komine-Aizawa; Shigefumi Maesaki; Thomas Vorup-Jensen; Paul Evan Kilgore; Hikaru Kohase; Tomonori Hoshino; Mitsuko Seki
Scientific Reports, May 2024 - 産婦人科における感染症学～プロからの伝承 女性生殖器における細菌叢とその役割
高田 和秀; 松田 恵里那; 早川 智; 川名 敬; 相澤 志保子[小峯]
日本産婦人科感染症学会誌, May 2024 - Genetic diversity and declining norovirus prevalence in infants and children during Japan's COVID-19 pandemic: a three-year molecular surveillance.
Ngan Thi Kim Pham; Pattara Khamrin; Yuko Shimizu-Onda; Sheikh Ariful Hoque; Quang Duy Trinh; Shihoko Komine-Aizawa; Shoko Okitsu; Niwat Maneekarn; Satoshi Hayakawa; Kazuaki Yoshimune; Hiroshi Ushijima
Archives of virology, Aug. 2023, Refereed - Outbreak of human astroviruses 1 and Melbourne 2 in acute gastroenteritis pediatric patients in Japan during the COVID-19 pandemic, 2021
Hiroshi Ushijima; Shuichi Nishimura; Yuko Shimizu-Onda; Ngan Thi Kim Pham; Quang Duy Trinh; Shoko Okitsu; Chika Takano; Kattareeya Kumthip; Sheikh Ariful Hoque; Shihoko Komine-Aizawa; Niwat Maneekarn; Satoshi Hayakawa; Pattara Khamrin
Journal of Infection and Public Health, Aug. 2023, Refereed - The Factors Influencing Pregnant Women’s Selection of Media Sources to Obtain Information on COVID-19 in Japan in 2021
Shihoko Komine-Aizawa; Naotake Yamada; Yasuo Haruyama; Masashi Deguchi; Mitsuru Fukuda; Kei Kawana; Gen Kobashi; Etsuko Miyagi; Hideto Yamada; Takashi Sugiyama; Satoshi Hayakawa
Vaccines, Apr. 2023, Refereed, Not invited
Lead - Roles of TGF-β1 in Viral Infection during Pregnancy: Research Update and Perspectives.
Quang Duy Trinh; Ngan Thi Kim Pham; Kazuhide Takada; Hiroshi Ushijima; Shihoko Komine-Aizawa; Satoshi Hayakawa
International journal of molecular sciences, Mar. 2023, Refereed - Female reproductive tract-organ axes.
Takada K; Melnikov VG; Kobayashi R; Komine-Aizawa S; Tsuji NM; Hayakawa S
Front Immunol., Jan. 2023, Refereed - Pathological roles of antimicrobial peptides and pro-inflammatory factors secreted from the cervical epithelium in Gardnerella vaginalis-abundant vaginal flora in pregnancy
Matsuda E; Takada K; Kobayashi O; Nakajima T; Ikeda Y; Asai-Sato M; Kawakami K; Komatsu A; Chishima F; Komine-Aizawa S; Hayakawa S; Kawana K.
J Reprod Immunol., Jan. 2023, Refereed, Invited - The Induction of Antigen 85B-Specific CD8+ T Cells by Recombinant BCG Protects against Mycobacterial Infection in Mice
Komine-Aizawa S; Mizuno S; Kawano A; Hayakawa S; Matsuo K; Honda M.
Int J Mol Sci, Jan. 2023, Refereed, Invited
Lead - The association of three doses of the BNT162b2 mRNA vaccine with abnormal bleeding and an irregular menstrual cycle among premenopausal females: A single institute observation study
Namiki T; Komine-Aizawa S; Takada K; Takano C; Trinh QD; Hayakawa S.
J Obstet Gynaecol Res., Nov. 2022, Refereed, Not invited
Lead - Anti-tumor effects of perampanel in malignant glioma cells
Tatsuoka J; Sano E; Hanashima Y; Yagi C; Yamamuro S; Sumi K; Hara H; Takada K; Kanemaru K; Komine-Aizawa S; Katayama Y; Yoshino A.
Oncol Lett., Oct. 2022, Refereed, Not invited - TGF-β1 Promotes Zika Virus Infection in Immortalized Human First-Trimester Trophoblasts via the Smad Pathway
Trinh QD; Pham NTK; Takada K; Takano C; Komine-Aizawa S; Hayakawa S.
Cells, Sep. 2022, Refereed, Not invited - Massive intravascular hemolysis is an important factor in Clostridium perfringens-induced bacteremia.
Suzaki A; Komine-Aizawa S; Nishiyama H; Hayakawa S.
Intern Emerg Med, Aug. 2022, Refereed, Not invited - Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells.
Takano C; Horie M; Taiko I; Trinh QD; Kanemaru K; Komine-Aizawa S; Hayakawa S; Miki T.
Stem Cell Rev Rep, Aug. 2022, Refereed, Not invited - Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions
Trinh QD; Takada K; Pham NTK; Takano C; Namiki T; Ikuta R; Hayashida S; Okitsu S; Ushijima H; Komine-Aizawa S; Hayakawa S.
Front Microbiol, Jul. 2022, Refereed, Not invited - Restriction of SARS-CoV-2 replication in the human placenta.
Takada K; Shimodai-Yamada S; Suzuki M; Trinh QD; Takano C; Kawakami K; Asai-Sato M; Komatsu A; Okahashi A; Nagano N; Misawa T; Yamaguchi K; Suzuki T; Kawana K; Morioka I; Yamada H; Hayakawa S; Hao H; Komine-Aizawa S.
Placenta, Jul. 2022, Refereed, Not invited
Last - Emerging norovirus GII.4 Sydney[P31] causing acute gastroenteritis outbreak in children in Japan, during COVID-19, 2021
Pham NTK; Nishimura S; Shimizu-Onda Y; Trinh QD; Komine-Aizawa S; Khamrin P; Okitsu S; Sato S; Kobayashi T; Maneekarn N; Hayakawa S; Ushijima H.
J Infect Chemother., Jun. 2022, Refereed, Not invited - Low Susceptibility of Rubella Virus in First-Trimester Trophoblast Cell Lines.
Pham NTK; Trinh QD; Takada K; Komine-Aizawa S; Hayakawa S.
Viruses, May 2022, Refereed, Not invited - Intrauterine fetal death during COVID-19 pregnancy: Typical fetal heart rate changes, coagulopathy, and placentitis
Kato M; Yamaguchi K; Maegawa Y; Komine-Aizawa S; Kondo E; Ikeda T.
J Obstet Gynaecol Res., May 2022, Refereed, Not invited - Adverse events after BNT162b2 mRNA COVID-19 vaccination in health care workers and medical students in Japan
Namiki T; Komine-Aizawa S; Takada K; Takano C; Trinh QD; Hayakawa S.
J Infect Chemother., May 2022, Refereed, Not invited
Lead - The vaccination status and adverse effects of COVID-19 vaccine among pregnant women in Japan in 2021
Komine-Aizawa S; Haruyama Y; Deguchi M; Hayakawa S; Kawana K; Kobashi G; Miyagi E; Yamada H; Sugiyama T.
J Obstet Gynaecol Res., May 2022, Refereed, Invited
Lead - Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice
Endo-Umeda K; Nakashima H; Uno S; Toyoshima S; Umeda N; Komine-Aizawa S; Seki S; Makishima M.
Sci Rep., Nov. 2021, Refereed, Not invited - Pathogenic Characterization of Clostridium perfringens Strains Isolated From Patients With Massive Intravascular Hemolysis
Suzaki A; Ohtani K; Komine-Aizawa S; Matsumoto A; Kamiya S; Hayakawa S.
Front Microbiol., Jul. 2021, Refereed, Not invited - Lactobacillus crispatus promotes invasion of the HTR-8/SVneo trophoblast cell line
Yoshida T; Takada K; Komine-Aizawa S; Kamei Y; Ishihara O; Hayakawa S.
Placenta, Jun. 2021, Refereed, Not invited - Genetic diversity of Parechovirus A in infants and children with acute gastroenteritis in Japan during 2016–2018
Ngan Thi Kim Pham; Aksara Thongprachum; Yuko Shimizu; Itoe Shiota; Sheikh Ariful Hoque; Pattara Khamrin; Chika Takano; Quang Duy Trinh; Shoko Okitsu; Shihoko Komine-Aizawa; Hiroyuki Shimizu; Niwat Maneekarn; Satoshi Hayakawa; Hiroshi Ushijima
Infection, Genetics and Evolution, Jun. 2021, Refereed - An improved primer design for the loop-mediated isothermal amplification (LAMP) method to detect oxacillinase (OXA)-48 β-lactamase genes in Gram-negative bacteria for clinical applications.
Sasano M; Seki M; Takano C; Komine-Aizawa S; Hayakawa S.
J Infect Chemother, Apr. 2021, Refereed, Not invited - Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan.
Hayakawa S; Komine-Aizawa S; Takada K; Kimura T; Yamada H.
J Obstet Gynaecol Res., Mar. 2021, Refereed, Not invited
Corresponding - The Epithelial-to-Mesenchymal Transition-Like Process Induced by TGF-β1 Enhances Rubella Virus Binding and Infection in A549 Cells via the Smad Pathway.
Pham NTK; Trinh QD; Takada K; Takano C; Sasano M; Okitsu S; Ushijima H; Komine-Aizawa S; Hayakawa S.
Microorganisms., Mar. 2021, Refereed, Not invited - Asian tiger mosquitos (Aedes albopictus) in urban Tokyo, Japan show low cytochrome c oxidase subunit 1 diversity.
Namiki T; Komine-Aizawa S; Takada K; Hayakawa S
Entomological Science, Nov. 2020, Refereed, Not invited
Corresponding - COVID-19 pandemic and pregnancy
Hayakawa S; Komine-Aizawa S; Mor GG
J Obstet Gynaecol Res., Aug. 2020, Refereed, Not invited - Placental barrier against COVID-19
Komine-Aizawa S; Takada K; Hayakawa S.
Placenta, Jul. 2020, Refereed, Invited
Lead - Cow milk exosomes activate NK cells and γδT cells in human PBMCs in vitro
Komine-Aizawa S; Ito S; Aizawa S; Namiki T; Hayakawa S.
Immunol Med, Jul. 2020, Refereed, Not invited
Lead - Interleukin-22 promotes the migration and invasion of oral squamous cell carcinoma cells
Komine-Aizawa S; Aizawa S; Takano C; Hayakawa S.
Immunol Med, Jun. 2020, Refereed, Not invited
Lead - Diversity of human parechovirus in infants and children with acute gastroenteritis in Japan during 2014-2016.
Pham NTK; Thongprachum A; Shimizu Y; Trinh QD; Okitsu S; Komine-Aizawa S; Shimizu H; Hayakawa S; Ushijima H.
Infect Genet Evol., Aug. 2019, Refereed, Not invited - MHC-restricted Ag85B-specific CD8+ T cells are enhanced by recombinant BCG prime and DNA boost immunization in mice.
Komine-Aizawa S; Jiang J; Mizuno S; Hayakawa S; Matsuo K; Boyd LF; Margulies DH; Honda M.
Eur J Immunol., Jun. 2019, Refereed, Not invited
Lead - Relationship Between the Fecal Microbiota and Depression and Anxiety in Pediatric Patients With Orthostatic Intolerance.
Ishii W; Komine-Aizawa S; Takano C; Fujita Y; Morioka I; Hayakawa S.
Prim Care Companion CNS Disord., Apr. 2019, Refereed, Not invited
Corresponding - Periodontal diseases and adverse pregnancy outcomes.
Komine-Aizawa S; Aizawa S; Hayakawa S.
J Obstet Gynaecol Res., Jan. 2019, Refereed, Invited
Lead - Liver X receptors regulate hepatic F4/80 + CD11b+ Kupffer cells/macrophages and innate immune responses in mice
Kaori Endo-Umeda; Hiroyuki Nakashima; Shihoko Komine-Aizawa; Naoki Umeda; Shuhji Seki; Makoto Makishima
Scientific Reports, Dec. 2018, Refereed, Not invited - Synergistic induction of interferon-γ by interleukin-2, interleukin-12 and poly(I:C) in a human natural killer cell line.
Majima-Horiuchi H; Komine-Aizawa S; Karasaki-Suzuki M; Izumi Y; Aizawa S; Hayakawa S.
Immunol Med., Nov. 2018, Refereed, Not invited
Corresponding - Lactobacillus crispatus accelerates re-epithelialization in vaginal epithelial cell line MS74.
Takada K; Komine-Aizawa S; Kuramochi T; Ito S; Trinh QD; Pham NTK; Sasano M; Hayakawa S.
Am J Reprod Immunol., Aug. 2018, Refereed, Not invited
Corresponding - Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014-2016.
Ngan Thi Kim Pham; Aksara Thongprachum; Quang Duy Trinh; Shoko Okitsu; Shihoko Komine-Aizawa; Hiroyuki Shimizu; Satoshi Hayakawa; Hiroshi Ushijima
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, Jul. 2018, Refereed, Not invited - Frequent isolation of extended-spectrum beta-lactamase-producing bacteria from fecal samples of individuals with severe motor and intellectual disabilities
Chika Takano; Mitsuko Seki; Hiroaki Shiihara; Shihoko Komine-Aizawa; Kazumichi Kuroda; Shori Takahashi; Hiroshi Ushijima; Satoshi Hayakawa
Journal of Infection and Chemotherapy, Mar. 2018, Refereed, Not invited - Myelin Oligodendrocyte Glycoprotein-Independent Rubella Infection of Keratinocytes and Resistance of First-Trimester Trophoblast Cells to Rubella Virus In Vitro.
Trinh QD; Pham NTK; Takada K; Komine-Aizawa S; Hayakawa S.
Viruses, Jan. 2018, Refereed, Not invited - Porphyromonas gingivalis Suppresses Trophoblast Invasion by Soluble Factors
Naoko Hirohata; Shihoko Komine-Aizawa; Muneaki Tamura; Kuniyasu Ochiai; Masahiko Sugitani; Satoshi Hayakawa
JOURNAL OF PERIODONTOLOGY, Dec. 2017, Refereed, Not invited - P. Gingivalis Suppresses Trophoblast Invasion by Soluble Factors.
Hirohata N; Komine-Aizawa S; Tamura M; Ochiai K; Sugitani M; Hayakawa S
J Periodontol, Jul. 2017, Refereed, Not invited - Poly I:C induces collective migration of HaCaT keratinocytes via IL-8
Kazuhide Takada; Shihoko Komine-Aizawa; Naoko Hirohata; Quang Duy Trinh; Atsuyoshi Nishina; Hirokazu Kimura; Satoshi Hayakawa
BMC IMMUNOLOGY, Apr. 2017, Refereed, Not invited - Multiplex PCR for the Detection of 10 Viruses Causing Encephalitis/Encephalopathy and its Application to Clinical Samples Collected from Japanese Children with Suspected Viral Encephalitis/Encephalopathy
Ngan T. K. Pham; Hiroshi Ushijima; Aksara Thongprachum; Quang D. Trinh; Pattara Khamrin; Chikako Arakawa; Wakako Ishii; Shoko Okitsu; Shihoko Komine-Aizawa; Satoshi Hayakawa
CLINICAL LABORATORY, 2017, Refereed, Not invited - A 3-Month-Old Child with Acute Gastroenteritis with Enterovirus D68 Detected from Stool Specimen
Ngan T. K. Pham; Aksara Thongprachum; Tsuneyoshi Baba; Shoko Okitsu; Quang D. Trinh; Shihoko Komine-Aizawa; Hiroyuki Shimizu; Satoshi Hayakawa; Hiroshi Ushijima
CLINICAL LABORATORY, 2017, Refereed, Not invited - Antibiotics or Infection Itself? The Possible Importance of Inflammatory Cytokines on Mental States
Wakako Ishii; Shihoko Komine-Aizawa; Satoshi Hayakawa
JOURNAL OF CLINICAL PSYCHIATRY, Dec. 2016, Refereed, Not invited - Antibiotic Resistance of Campylobacter jejuni and C. coli Isolated from Children with Diarrhea in Thailand and Japan
Ngan Thi Kim Pham; Aksara Thongprachum; Dinh Nguyen Tran; Shuichi Nishimura; Yuko Shimizu-Onda; Quang Duy Trinh; Pattara Khamrin; Nuthapong Ukarapol; Tipachan Kongsricharoern; Shihoko Komine-Aizawa; Shoko Okitsu; Niwat Maneekarn; Satoshi Hayakawa; Hiroshi Ushijima
JAPANESE JOURNAL OF INFECTIOUS DISEASES, Jan. 2016, Refereed, Not invited - High Mobility Group Box 1 Protein Enhances HIV Replication in Newly Infected Primary T Cells
Quang D. Trinh; Ngan Thi Kim Pham; Kazumasa Fuwa; Kazuhide Takada; Shihoko Komine-Aizawa; Mitsuo Honda; Hiroshi Ushijima; Satoshi Hayakawa
CLINICAL LABORATORY, 2016, Refereed, Not invited - Loop-Mediated Isothermal Amplification (LAMP) for Detection of Campylobacter jejuni and C. coli in Thai Children with Diarrhea.
Pham NT; Trinh QD; Khamrin P; Ukarapol N; Kongsricharoern T; Yamazaki W; Komine-Aizawa S; Okitsu S; Maneekarn N; Hayakawa S; Ushijima H.
Jpn J Infect Dis., Apr. 2015, Refereed, Not invited - Plasma Osteopontin Predicts Inflammatory Bowel Disease Activities
Shihoko Komine-Aizawa; Hideki Masuda; Takerou Mazaki; Motomi Shiono; Satoshi Hayakawa; Tadatoshi Takayama
INTERNATIONAL SURGERY, Jan. 2015, Refereed, Not invited - Porphyromonas gingivalis lipopolysaccharide inhibits trophoblast invasion in the presence of nicotine
S. Komine-Aizawa; N. Hirohata; S. Aizawa; Y. Abiko; S. Hayakawa
PLACENTA, Jan. 2015, Refereed, Not invited - Prevalence and Antimicrobial Resistance of Campylobacter jejuni and Campylobacter coli from Adult Hospitalized Patients with Diarrhea in Thailand
Ngan Thi Kim Pham; Hiroshi Ushijima; Quang Duy Trinh; Pattara Khamrin; Shihoko Komine-Aizawa; Shoko Okitsu; Niwat Maneekarn; Satoshi Hayakawa
CLINICAL LABORATORY, 2015, Refereed, Not invited - 歯周病と全身疾患
廣畑直子、相澤聡一、相澤(小峯)志保子
日大医学雑誌, Oct. 2014, Refereed, Not invited
Corresponding - Suppression of osteoblast toll-like receptor 2 signaling by endothelin-1
Ai Suzaki; Shihoko Komine-Aizawa; Satoshi Hayakawa
Journal of Orthopaedic Research, 2014, Refereed, Not invited - 性感染症の最近の話題
相澤(小峯)志保子、早川 智
日大医学雑誌, Jun. 2013, Refereed, Not invited
Lead - HIV ワクチン開発の現状と課題点 ―組み換え遺伝子ワクチンの開発―
本多三男、相澤(小峯)志保子、泉 泰之、早川 智
日大医学雑誌, Jun. 2013, Refereed, Not invited - Seroprevalence of Chlamydophila pneumoniae in HIV-infected children in Vietnam
Quang Duy Trinh; Ngan Thi Kim Pham; Nhut Tin Le Nguyen; Bao Quoc Lam; Kim Thoa Le Phan; Khanh Huu Truong; Thinh Quoc Le; Hung Thanh Nguyen; Thuong Chi Tang; Yasuyuki Izumi; Shihoko Komine-Aizawa; Hiroshi Ushijima; Satoshi Hayakawa
Journal of Infection and Chemotherapy, 2013, Refereed, Not invited - The virucidal effect against murine norovirus and feline calicivirus as surrogates for human norovirus by ethanol-based sanitizers
Yuko Shimizu-Onda; Tempei Akasaka; Fumihiro Yagyu; Shihoko Komine-Aizawa; Yukinobu Tohya; Satoshi Hayakawa; Hiroshi Ushijima
Journal of Infection and Chemotherapy, 2013, Refereed, Not invited - H1N1/09 Influenza A Virus Infection of Immortalized First Trimester Human Trophoblast Cell Lines
Shihoko Komine-Aizawa; Ai Suzaki; Quang D. Trinh; Yasuyuki Izumi; Toshikatsu Shibata; Kazumichi Kuroda; Satoshi Hayakawa
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Sep. 2012, Refereed, Not invited - Drug Resistance Mutations in the HIV Type 1 Protease and Reverse Transcriptase Genes in Antiretroviral-Naive Vietnamese Children.
Trinh QD; Pham NT; Le Nguyen NT; Lam BQ; Le Phan KT; Truong KH; Izumi Y; Komine-Aizawa S; Mizuguchi M; Ushijima H; Hayakawa S.
AIDS Res Hum Retroviruses, Mar. 2012, Refereed, Not invited - The therapeutic potential of the recombinant antigen from Dirofilaria immitis (rDiAg) for immune-mediated pregnancy loss
Shihoko Komine-Aizawa; Yasuyuki Izumi; Shinjiro Imai; Koichiro Fujita; Satoshi Hayakawa
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Dec. 2011, Refereed, Not invited - Influence of Advanced Age on Mycobacterium bovis BCG Vaccination in Guinea Pigs Aerogenically Infected with Mycobacterium tuberculosis
Shihoko Komine-Aizawa; Toshio Yamazaki; Tsuyoshi Yamazaki; Shin-ichiro Hattori; Yuji Miyamoto; Naoki Yamamoto; Shinji Haga; Masahiko Sugitani; Mitsuo Honda; Satoshi Hayakawa; Saburo Yamamoto
CLINICAL AND VACCINE IMMUNOLOGY, Oct. 2010, Refereed, Not invited - ヒト末梢血単核細胞におけるインフルエンザHA抗原特異的interferon-gamma産生に対する漢方薬の影響
寺本紘子; 相澤志保子[小峯]; 真島洋子; 泉泰之; 芝田克敏; 黒田和道; 早川智
日大医学雑誌, Feb. 2009, Refereed, Not invited
Corresponding - H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines and induces their rapid apoptosis
Quang Duy Trinh; Yasuyuki Izumi; Shihoko Komine-Aizawa; Toshikatsu Shibata; Yoshitaka Shimotai; Kazumichi Kuroda; Masashi Mizuguchi; Hiroshi Ushijima; Gil Mor; Satoshi Hayakawa
American Journal of Reproductive Immunology, 2009, Refereed, Not invited - インフルエンザウイルスはヒト絨毛癌細胞株に感染しアポトーシスを起こす
相澤 志保子[小峯]; 芝田 敏克; Trinh Duy Quang; 泉 泰之; 真島 洋子; 太田 邦明; 黒田 和道; 早川 智
Reproductive Immunology and Biology, Nov. 2008 - 【産婦人科感染症診療マニュアル】胎児・新生児の免疫機構
真島 洋子; 早川 智; 相澤 志保子; 泉 泰之; Trinh Duy Quang; 太田 邦明; 須崎 愛
産科と婦人科, Nov. 2008 - Stimuli through Toll-like receptor (TLR) 3 and 9 affect human chorionic gonadotropin (hCG) production in a choriocarcinoma cell line
Shihoko Komine-Aizawa; Hiroko Majima; Chiikako Yoshida-Noro; Satoshi Hayakawa
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Apr. 2008, Refereed, Not invited - 結核菌感染防御システム ―CD1 による脂質抗原提示―
相澤(小峯)志保子、本多三男、早川 智
日大医学雑誌, Aug. 2007, Refereed, Not invited
Lead - Rembrandt's Maria Bockenolle has a butterfly rash and digital deformities: Overlapping syndrome of rheumatoid arthritis and systemic lupus erythematosus
Satoshi Hayakawa; Shihoko Komine-Aizawa; Shunzo Osaka; Toshihiro Iida; Junko Hayakawa; Susumu Nishinarita; Norimichi Nemoto
MEDICAL HYPOTHESES, 2007, Refereed, Not invited - The death of Izanami, an ancient Japanese goddess: An early report of a case of puerperal fever
Satoshi Hyakakawa; Shihoko Komine-Aizawa; Satoshi Naganawa; Kazufumi Shimuzu; Norimichi Nemoto
MEDICAL HYPOTHESES, 2006, Refereed, Invited - アロマテラピーに用いられる芳香物質のHIV感染に及ぼす影響 MAGIC-5細胞を用いたin vitroでの検討
長縄 聡,早川 智,相澤志保子,清水一史,北村勝彦,本多三男,陳 旺全,鄭 端棠
アロマテラピー学雑誌, 2006, Refereed, Not invited - Granulocyte colony-stimulating factor suppresses autologous tumor killing activity of the peripheral blood lymphocytes in the patients with ovarian carcinoma
Y Ohta; S Hayakawa; M Karasaki-Suzuki; K Sugita; S Komine; F Chishima; Y Hatta; T Horie; N Seo; A Sheikh; N Nemoto; T Yamamoto
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Jul. 2004, Refereed, Not invited
MISC
- 【産婦人科医が知っておきたい プレコンセプションケアの最前線(II)】ウイルス感染症とプレコンセプションケア
相澤 志保子[小峯]; 早川 智
産婦人科の実際, Jun. 2024 - 【母子感染の最新知識】総論 胎児・胎盤の感染防御機構 母子感染の成り立ち
相澤 志保子[小峯]; 高田 和秀; Trinh Duy Quang; 早川 智
周産期医学, May 2024 - 妊娠中のワクチン接種に関する産婦人科医を対象としたアンケート調査
相澤 志保子[小峯]; 早川 智
日本産婦人科感染症学会誌, May 2024 - 子宮内細菌叢がmaternal-fetal interfaceにおける免疫寛容機序に与える影響の研究
高田 和秀; Bae Jonghyun; Trinh Quang Duy; 相澤 志保子[小峯]; Kim Dong Wook; 早川 智
Reproductive Immunology and Biology, Nov. 2023 - 【新型コロナウイルス感染症と周産期医療】産科医療への影響 SARS-CoV-2感染症での胎盤の変化
高田 和秀; 相澤 志保子[小峯]; 早川 智
周産期医学, Oct. 2023 - 小児急性虫垂炎における虫垂内および口腔内細菌叢の解析
生田 稜; 高田 和秀; 高野 智圭; 上原 秀一郎; 相澤 志保子; 越永 従道; 早川 智
日本小児外科学会雑誌, May 2023 - BCGと感染症
相澤 志保子[小峯]
日大医学雑誌, Apr. 2023, Refereed, Invited
Lead - BNT162b2 mRNA COVID-19ワクチン接種後の有害事象
相澤(小峯)志保子、早川 智
臨床免疫・アレルギー科, 25 Jan. 2023, Not refereed, Invited
Lead - 歯周病が妊娠合併症と関連するのはなぜ？
相澤(小峯)志保子、相澤聡一、早川 智
産科と婦人科, Nov. 2022, Not refereed, Invited
Lead - 日本大学医学部資料室に収蔵される4点のはしか絵の解析 本文の読み下し文に見る幕末庶民の医学思想
山本 憧; 並木 貴宏; 高田 和秀; 相澤 志保子[小峯]; 早川 智
日大医学雑誌, Oct. 2022 - 新型コロナウイルス感染症と不妊治療
相澤(小峯)志保子
薬局, Sep. 2022, Not refereed, Invited
Lead - 【新型コロナウイルス感染症が産婦人科診療に与えた影響】【I.現状と対策】女性や妊婦におけるワクチン接種の現状
相澤(小峯)志保子,早川 智
産科と婦人科, Mar. 2022, Not refereed, Invited
Lead - 感染症 SARS-CoV-2と胎盤関門
相澤 志保子[小峯]; 高田 和秀; Trinh Duy Quang; 早川 智
Reproductive Immunology and Biology, Nov. 2021 - 新型コロナウイルス感染の母親から出生した双胎児例 子宮内感染に関する胎盤所見からの考察
森岡 一朗; 高田 和秀; 長野 伸彦; 岡橋 彩; 川上 香織; 小松 篤史; 川名 敬; 鈴木 高祐; 増田 しのぶ; 高野 智圭; Trinh Duy Quang; 相澤 志保子[小峯]; 早川 智
Reproductive Immunology and Biology, Nov. 2021 - 細菌性腟症原因菌と腟常在菌が子宮頸管上皮細胞の抗菌ペプチド産生に及ぼす影響
松田 恵里那; 高田 和秀; 相澤 志保子[小峯]; 早川 智; 川名 敬
Reproductive Immunology and Biology, Nov. 2021 - 小胞体ストレスは不死化絨毛細胞株の風疹ウイルス感受性を誘導する
Quang Duy Quang; 高田 和秀; Pham Thi Kim Ngan; 高野 智圭; 相澤 志保子[小峯]; 早川 智
Reproductive Immunology and Biology, Nov. 2021 - Lactobacillus crispatusは不死化絨毛細胞株HTR-8/SVneoの浸潤を促進するがGardnerella vaginalisは抑制する
高田 和秀; 吉田 智昭; 相澤 志保子[小峯)]; 亀井 良政; 石原 理; 早川 智
Reproductive Immunology and Biology, Nov. 2021 - アレルギー疾患 先天性代謝異常症では食物アレルギー有病率が低い
高野 智圭; 小川 えりか; 岩間 元子; 豊島 翔太; 市野井 那津子; 石毛 美夏; 相澤 志保子; 岡山 吉道; 早川 智; 日本大学医学部医学教育センター免疫・アレルギー学プロジェクトチーム
日本臨床免疫学会総会プログラム・抄録集, Oct. 2021 - 【口腔と全身疾患研究の最前線】口腔内細菌と妊娠
相澤(小峯)志保子
医学のあゆみ, Jun. 2021, Not refereed, Invited
Lead - 性感染症の現状と問題点 HIV感染/AIDS
相澤(小峯)志保子
産婦人科の実際, Jan. 2021, Not refereed, Invited
Lead - 口腔マイクロバイオームとその産科的意義 歯周疾患と妊娠合併症
別冊BIO Clinica 慢性炎症と疾患, 30 Nov. 2017, Not refereed, Invited
Lead - Enhanced vaginal re-epithelialization in vitro by Lactobacillus crispatus
Kazuhide Takada; Shihoko Komine-Aizawa; Quang Duy Trinh; Satoshi Hayakawa
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Nov. 2017, Not refereed, Not invited - High-mobility group box 1 protein enhances HIV replication in newly infected primary T cells
Quang Duy Trinh; Kazuhide Takada; Shihoko Komine-Aizawa; Satoshi Hayakawa
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Nov. 2017, Not refereed, Not invited - 口腔常在細菌とその臨床的意義 歯周疾患と妊娠合併症
日本臨床腸内微生物学会誌, May 2016, Not refereed, Invited
Lead - CBA/J×DBA/2J流産マウスモデルにおける"当帰芍薬散""柴苓湯"の効果
相澤(小峯)志保子、早川 智
産婦人科漢方研究のあゆみ, Apr. 2012, Not refereed, Not invited
Lead - 感染症と不育症
相澤(小峯)志保子、早川 智
産婦人科の実際, Oct. 2011, Not refereed, Invited
Lead - CD8+T cell populations of distinct fine specificity are elicited by immunization with different HIV-1 Env vaccines
Mitsuo Honda; Shihoko Aizawa; Yasuyuki Izumi; Satoshi Hayakawa
EUROPEAN JOURNAL OF MEDICAL RESEARCH, Aug. 2010, Not refereed, Not invited - 【妊娠感染症を考える】女性生殖器・脱落膜の免疫と母子感染
早川 智、真島洋子、泉 泰之、Trinh QD、Nabandith Viengvansay、相澤志保子(小峯)
産婦人科の実際, May 2008, Not refereed, Not invited - 粘膜免疫からの感染と免疫応答機構 体の入口から呼吸器・消化器・生殖器・皮膚までの制御システム 生殖器の感染症 女性生殖器における免疫機構
早川 智,真島洋子,相澤志保子
実験医学, 2007, Not refereed, Not invited - 産科 母子感染のスクリーニング HIV
相澤(小峯)志保子,早川 智
産婦人科の実際, 2006, Not refereed, Not invited
Lead - HIV垂直感染と胎盤関門
相澤(小峯)志保子,早川 智,長縄 聡,永石(石井)真木,本多三男,砂川恵伸,根本則道
炎症と免疫, 2006, Not refereed, Not invited
Lead - HIV感染症・AIDS
早川純子,早川 智,小峯志保子,本多三男,西成田進
産科と婦人科, 2005, Not refereed, Not invited - HIV感染症/AIDS
早川純子,早川 智,相澤(小峯)志保子,西成田進,本多三男
産科と婦人科, 2005, Not refereed, Not invited - 妊娠とウイルス感染
早川 智,椙田賢司,小峯志保子,千島史尚,本多三男,山本樹生
産婦人科治療, 2002, Not refereed, Not invited
Books and other publications
- Reproductive Immunology (Edited by Gil Mor). Chapter 20: Interactions between the epithelial barrier and the microbiota in the reproductive tract.
Joint work, Chapter 20: Interactions between the epithelial barrier and the microbiota in the reproductive tract., Takada K; Komine-Aizawa S; Tsuji N; Hayakawa S
Academic press., 2021 - ヒト常在菌叢と生理機能・全身疾患
Joint work, 第16章 妊娠合併症
シーエムシー出版, Aug. 2020 - 実践 臨床生殖免疫学
Joint work, 425-429
中外医学社, May 2018, Not refereed - 腸内細菌・口腔細菌と全身疾患
Joint work
シーエムシー出版, Dec. 2015, Not refereed - 歯周病予防のストラテジー
Joint work, 108-110
医歯薬出版株式会社, Dec. 2009, Not refereed - 産婦人科 専門医にきく最新の臨床
Joint work, 38-41
中外医学社, Apr. 2007, Not refereed
9784498060425
Lectures, oral presentations, etc.
- Tandem mass tag systemによるSARS-CoV-2感染における胎盤感受性影響因子の探索
高田 和秀; トリン・ズイ・クアン; 相澤 志保子[小峯]; 富永 大介; 辻 典子; 山田 秀人; 早川 智
日本臨床免疫学会総会プログラム・抄録集, Oct. 2023, (一社)日本臨床免疫学会 - 口腔細菌は虫垂細菌叢の改変を介して小児急性虫垂炎の病態に関与する
生田 稜; 高田 和秀; 高野 智圭; 相澤 志保子; 上原 秀一郎; 早川 智
日本臨床免疫学会総会プログラム・抄録集, Oct. 2023, (一社)日本臨床免疫学会 - 小児急性虫垂炎において口腔内細菌が虫垂細菌叢に及ぼす影響
生田 稜; 高田 和秀; 高野 智圭; 相澤 志保子[小峯]; 上原 秀一郎; 早川 智
日本臨床腸内微生物学会総会・学術集会プログラム・抄録集, Aug. 2023, 日本臨床腸内微生物学会 - 抗菌薬と薬剤耐性 薬剤耐性遺伝子の分子診断
高野 智圭; 笹野 まり; 関 みつ子; 樽本 憲人; 相澤 志保子[小峯]; 早川 智
日本産婦人科感染症学会誌, May 2023, (一社)日本産婦人科感染症学会 - Tandem mass tag systemによるSARS-CoV-2感染胎盤のプロテオミクス解析
高田 和秀; Trinh Quang Duy; 相澤 志保子[小峯]; 富永 大介; 辻 典子; 山田 秀人; 早川 智
日本産婦人科感染症学会誌, May 2023, (一社)日本産婦人科感染症学会 - アンプリコンシーケンス解析を用いた小児急性虫垂炎の口腔内および虫垂内細菌叢の検討
生田 稜; 高田 和秀; 高野 智圭; 上原 秀一郎; 相澤 志保子[小峯]; 越永 従道; 早川 智
日本外科学会定期学術集会抄録集, Apr. 2023, (一社)日本外科学会 - 次世代シークエンサーを用いた小児急性虫垂炎における口腔内細菌叢と虫垂内細菌叢の検討
生田 稜; 高田 和秀; 高野 智圭; 上原 秀一郎; 相澤 志保子[小峯]; 越永 従道; 早川 智
日本腹部救急医学会雑誌, Feb. 2023, (一社)日本腹部救急医学会 - SARS-CoV-2に対する胎盤バリアメカニズムの検討
高田 和秀; 山田 清香; 鈴木 真由美; Trinh Quang Duy; 高野 智圭; 川上 香織; 佐藤 美紀子; 小松 篤史; 岡橋 彩; 長野 伸彦; 三澤 俊哉; 山口 恭平; 川名 敬; 森岡 一朗; 山田 秀人; 早川 智; 羽尾 裕之; 相澤 志保子
第38回日本産婦人科感染症学会学術集会, May 2022, Not invited - 産婦人科からみたCOVID-19への取り組み 日本産婦人科感染症学会として我々はCOVID-19にどのように立ち向かってきたのか
相澤 志保子; 早川 智; 山田 秀人
第38回日本産婦人科感染症学会学術集会, May 2022, Invited - SARS-CoV-2と胎盤関門
髙田和秀 Trinh Duy Quang 早川 智
第36回日本生殖免疫学会・学術集会, Oct. 2021, Invited - 老化による腸管内T細胞の機能低下と乳酸菌C60株による活性化機構
齋藤 卓; 柿崎 奈々恵; 前川 利男; 奥野 海良人; 福井 竜太郎; 高田 和秀; 相澤 志保子; 早川 智; 三宅 健介; 辻 典子
第24回日本臨床腸内微生物学会総会・学術集会, Aug. 2021, Not invited - ヒト不死化腸管上皮細胞株を用いたSARS-CoV-2複製に対するLactobacillusの影響の検討
高田 和秀; Trinh Duy Quang; 生田 稜; 相澤 志保子[小峯]; 辻 典子; 早川 智
第24回日本臨床腸内微生物学会総会・学術集会, Aug. 2021, Not invited - 乳酸菌C60株が誘導するIL-10産生型CD4陽性T細胞の腸炎に対する保護効果
乳酸菌C60株が誘導するIL-10産生型CD4陽性T細胞の腸炎に対する保護効果(会議録); 齋藤 卓; 柿崎 奈々恵; 前川 利男; 奥野 海良人; 福井 竜太郎; 高田 和秀; 相澤 志保子; 早川 智; 三宅 健介; 辻 典子
第24回日本臨床腸内微生物学会総会・学術集会, Aug. 2021, Not invited - SARS-CoV-2は胎盤関門を突破するか？
相澤(小峯)志保子
第57回日本周産期・新生児医学会総会および学術集会, Jul. 2021, Invited - SARS-CoV-2 infects human trophoblasts but proliferate limitedly.
Shihoko Komine-Aizawa; Satoshi Hayakawa
第73回日本産科婦人科学会, Apr. 2021, Not invited - COVID-19と妊娠
3大学医工連携セミナー, Nov. 2020, Invited - 免疫疾患と妊娠〜関節リウマチ を踏まえて〜
第7回JCRベーシックリサーチカンファレンス, Oct. 2020, Not invited - 歯周病原因菌は胎盤形成阻害に加えて母子免疫寛容を破綻させる
第48回日本臨床免疫学会総会, Oct. 2020, Not invited - Recombinant BCG over-expressed Mycobacterium antigens enhanced Ag85B-specific CD8+ T cells.
Shihoko Komine-Aizawa; Satoru Mizuno; Satoshi Hayakawa; Kazuhiro Matsuo; Mitsuo Honda
第48回日本免疫学会学術集会, Dec. 2019, Not invited - Periodontal Diseases and Adverse Pregnancy Outcomes
Shihoko Komine-Aizawa
14th World Congress of the International Society for Immunology of Reproduction, Nov. 2019, Not invited - Induction of antigen 85B-specific CD8+ T cells by recombinant BCG protects against mycobacterial infection
Shihoko Komine-Aizawa; Satoru Mizuno; Satoshi Hayakawa; Kazuhiro Matsuo; Mitsuo Honda
第47回日本免疫学会学術集会, Dec. 2018, Not invited - 生殖免疫の基礎と臨床
第46回日本臨床免疫学会総会, Nov. 2018, Invited - 組換えBCGワクチンによる抗酸菌特異的免疫の誘導と結核防御効果
第88回実験結核研究会, Jun. 2018, Not invited - Induction of CD8+- MHC-I-restricted, antigen-specific T cells by recombinant BCG protects against mycobacterial infection
第46回日本免疫学会総会・学術集会, Dec. 2017, Not invited - Induction of CD8+- H2-Kd-restricted, antigen 85B-specific T cells by recombinant BCG protects against mycobacterial infection
ConBio2017, Dec. 2017, Not invited - 梅毒 温故知新
第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Not invited - 非結核性抗酸菌防御能に優れた組換えBCGワクチンの開発
第91回日本感染症学会総会・学術講演会, Apr. 2017, Not invited - 抗酸菌由来Ag85Bの抗原提示における免疫学的解析
相澤志保子、本多三男、松尾和浩、早川 智
第87回実験結核研究会, Mar. 2017, Not invited - MHC Class I presentation by highly functional epitope peptide of M. tuberculosis shared among mycobacterial antigen 85 complex
第45回日本免疫学会学術集会, Dec. 2016, Not invited - M. tubercuolosis-specific CD8 T cell spitopes binding to MHC class I molecule
第39回日本分子生物学会年会, Dec. 2016, Not invited - MHC Class I presentation by highly functional epitope peptides of M. tuberculosis shared among the antigen 85 complex
相澤(小峯)志保子、早川 智、松尾和浩、本多三男
第86回実験結核研究会総会, May 2016, Not invited - rBCG/Ag85B confers enhanced levels of polyfunctional CD8+ T cell induction by co-inducing antigen-specific CD4+ T cells
Shihoko Komine-Aizawa; Satoshi Hayakawa; Kazuhiro Matsuo; Mitsuo Honda
第44回日本免疫学会学術集会, Nov. 2015, Not invited - 歯周疾患と妊娠合併症
相澤(小峯)志保子
第18回日本臨床腸内微生物学会総会・学術集会, Aug. 2015, Invited - Methanobrevibacter smithiiとMethanobrevibacter oralisがヒトの免疫系に与える影響
相澤(小峯)志保子、早川 智
第28回日本アーキア研究会講演会, Jul. 2015, Not invited - 哺乳類細胞で発現可能な新規組換えBCGワクチンの開発
相澤(小峯)志保子、早川 智、松尾和浩、本多三男
第85回実験結核研究会総会, Mar. 2015, Not invited - 女性の各ライフステージでの感染症の実態と対策 HIVと抗酸菌感染症
相澤(小峯)志保子
日本女性医学学会, Nov. 2014 - 女性の各ライフステージでの感染症の実態と対策HIVと抗酸菌感染症
相澤(小峯)志保子
日本女性医学学会, Nov. 2014, Not invited - BCGワクチンによる結核防御免疫能の解析
相澤(小峯)志保子
第46回日本臨床分子形態学会, Oct. 2014, Not invited - 生殖免疫学領域における動物モデル
第42回日本臨床免疫学会総会, Sep. 2014, Not invited - BCGワクチン免疫型の特性と特異的CD8エフェクターT細胞誘導の付与
相澤(小峯)志保子、山崎 剛、早川 智 松尾和浩、本多三男
第84回実験結核研究会総会, May 2014, Not invited - Cytokine patterns in the cervical secretion of CIN treated with phenol-therapy
第66回日本産科婦人科学会学術講演会, Apr. 2014, Not invited - Recombinant BCG expressing a major mycobacterial antigen-85B α-K elicits functional BCG–specific CD8+ T cells
Shihoko Komine-Aizawa; Satoshi Hayakawa; Kazuhiro Matsuo Mitsuo Honda
第43回日本免疫学会学術集会, 2014, Not invited - 2009年に発生した新型インフルエンザウイルス(A/H1N1)の胎盤傷害性について
第65回日本産科婦人科学会学術講演会, May 2013, Not invited - CBA/J × DBA/2J反復流産マウスモデルに対する新たな治療戦略と免疫学的解析
早川 智
第64回日本産科婦人科学会学術講演会, Apr. 2012, Not invited - 流産マウスモデルにおける新しい流産予防治療の開発
早川 智
第26回日本生殖免疫学会総会・学術総会, Dec. 2011, Not invited - Pandemic H1N1/2009 Influenza virus replicates in Immortalized Human First Trimester Trophoblast Cell Lines Without Cytopathic Effects
Shihoko Komine-Aizawa; Ai Suzaki; Toshikatsu Shibata; Kazumichi Kuroda; Satoshi Hayakawa
The XXII Asian and Oceanic Congress of Obstetrics and Gynecology, Sep. 2011, Not invited - ブタ由来新型インフルエンザウイルス(H1N1)が初期胎盤絨毛に与える影響．
早川 智
第63回日本産科婦人科学会学術講演会, Aug. 2011, Not invited - Synergistic effects of caffeine or nicotine and Porphyromonas gingivalis-derived LPS on matrigel invasion of an immortalized human first trimester trophoblast cell line.
Shihoko Komine-Aizawa; Yoshimitsu Abiko; Satoshi Hayakawa
31st Annual meeting, American Society for Reproductive Immunology, May 2011, Not invited - Toll-like receptorの胎盤における機能
相澤(小峯)志保子
第4回母児間免疫病勉強会, May 2011, Invited - Recombinant antigen from a nematoda parasite, Dirofilaria immitis (rDiAg) has the therapeutic potential for immune mediated pregnancy loss
Shihoko Komine-Aizawa; Y.Izumi; S.Imai; K.Fujita; S.Hayakawa
International Symposium for Immunology of Reproduction, Aug. 2010, Not invited - The therapeutic potential of the recombinant antigen from Dirofilaria immitis (rDiAg) for immune mediated pregnancy loss.
Shihoko Komine-Aizawa; Y.Izumi; S.Imai; K.Fujita; S.Hayakawa
14th International Congress of Immunology, Aug. 2010, Not invited - P. gingivalis LPSはカフェインあるいはニコチン存在下に栄養膜細胞浸潤を抑制する
相澤(小峯)志保子; 宮田真理子、安孫子宜光、Gil Mor、早川智
日本生殖免疫学会, Nov. 2009, Not invited - インフルエンザウイルスは不死化ヒト初期胎盤絨毛細胞株に感染しアポトーシスを起こす
クアントリン・ズイ、早川 智、相澤志保子、真島洋子、太田邦明
日本感染症学会, Apr. 2009, Not invited - 母体末梢血と臍帯血における酸化ストレスマーカーの差異について ―酸化ストレスバリアとしての胎盤の役割―
太田邦明、早川 智、前村俊満、相澤志保子、真島洋子、古川隆正、森田峰人
日本産科婦人科学会, Apr. 2009, Not invited - インフルエンザウイルスはヒト絨毛癌細胞株に感染しアポトーシスを起こす
相澤(小峯)志保子、真島洋子、早川 智
日本産科婦人科学会, Apr. 2009, Not invited - インフルエンザウイルスはヒト絨毛癌細胞株に感染しアポトーシスを起こす
相澤(小峯)志保子、芝田敏克、Trinh Duy Quang、泉 泰之、真島洋子、太田邦明、黒田和道、早川 智
日本生殖免疫学会, Dec. 2008, Not invited - ヒト末梢血リンパ球によるインフルエンザHA抗原特異的IFN-γ産生に対する漢方薬の影響
寺本紘子、相澤(小峯)志保子、真島洋子、泉 泰之、早川 智
産婦人科漢方研究会, Sep. 2008, Not invited - Stimuli through toll-like receptor 3 and 9 affect human chorionic gonadotropin production by a choriocarcinoma cell line.
Shihoko Komine-Aizawa; Hiroko Majima; Satoshi Hayakawa
American Society for Reproductive Immunology, Jun. 2008, Not invited - Th1 response of lymphocytes in human cord blood is activated by the component of Gram-positive bacteria
Hiroko Majima; Shihoko Komine-Aizawa; Takeshi Kinebuchi; Miki Karasaki-Suzuki; Fumihisa Chishima; Tatsuo Yamamoto; Shin Aizawa; Satoshi Hayakawa
American Society for Reproductive Immunology, Jun. 2008, Not invited - HIV母子感染における胎盤関門の解析（ワークショップ：HIVの母子感染）
相澤志保子、泉 泰之、長縄 聡、本多三男、北村勝彦、稲葉憲之、山本直樹、早川 智
日本感染症学会, Apr. 2008, Not invited - ヒト絨毛癌細胞株BeWoに歯周病原菌由来LPSが与える影響
相澤(小峯)志保子、真島洋子、早川 智
日本産科婦人科学会, Apr. 2008, Not invited - ヒト絨毛癌細胞株BeWoに歯周病原菌由来LPSが与える影響
相澤(小峯)志保子、真島洋子、早川 智、安孫子宜光
日本生殖免疫学会, Dec. 2007, Not invited - グラム陽性菌成分は臍帯血リンパ球のTh1応答を増強する
真島洋子、相澤(小峯)志保子、木根渕猛、唐崎美喜、千島史尚、山本樹生、早川 智
日本生殖免疫学会, Dec. 2007, Not invited - cAMP dependent induction of human chorionic gonadotropin (hCG) by toll like receptor (TLR) 3 and 9 signaling in a choriocarcinoma cell line BeWo
Shihoko Komine-Aizawa; Hiroko Majima; Chikako Yoshida-Noro; Satoshi Hayakawa
日本胎盤学会, Nov. 2007, Not invited - Stimuli through toll like receptor (TLR) 3 and 9 affect human chorionic gonadotropin (hCG) production by a choriocarcinoma cell line
AIZAWA-KOMINE Shihoko; MAJIMA Hiroko; HAYAKAWA Satoshi
日本免疫学会, Nov. 2007, Not invited - TRLを介した刺激はCD56陽性大顆粒NK, NKT細胞株のIFN-γ産生を調節する
真島洋子、鈴木美喜、木根渕猛、千島史尚、相澤志保子、早川 智
日本免疫学会, Nov. 2007, Not invited - 当帰芍薬散は内在性レトロウイルスenv遺伝子産物syncytinを介して絨毛細胞癌株BeWoの分化とhCG産生を促進する
相澤(小峯)志保子、真島洋子、野呂知加子、早川 智
産婦人科漢方研究会, Sep. 2007, Not invited - 加齢モルモットにおけるBCGワクチン再接種の結核防御効果
加齢モルモットにおけるBCGワクチン再接種の結核防御効果
日本結核病学会, Jun. 2007, Not invited - 結核菌の噴霧感染実験によるBCGワクチン効果の有効性、持続性の再評価
山崎利雄、相澤(小峯)志保子、服部真一朗、宮本友司、山本三郎
実験結核研究会, Jun. 2007, Not invited - Smoking behavior suppresses influenza specific peripheral T cells immune response ex vivo.
AIZAWA-KOMINE Shihoko; NAGANAWA Satoshi; MAJIMA Hiroko; HAYAKAWA Satoshi; SHIMIZU Kazufumi
日本免疫学会, Dec. 2006, Not invited - 甘遂（カンツイ）由来の新規テルペノイド誘導体の抗HIV活性の検討．
長縄 聡、菱山和義、松崎圭一、相澤(小峯)志保子、真島洋子、北村勝彦、北中 進、早川 智
日本エイズ学会, Nov. 2006, Not invited - NicotineはHPVに対する免疫応答を抑制する
早川 智、相澤志保子、太田郁子、千島史尚、鈴木美喜、太田啓明、山本樹生
日本産科婦人科学会, Apr. 2006, Not invited - 南米産薬用植物Landenbergia hexandra Klotzshの成分研究と抗HIV活性について
加茂智嗣、牧野三津子、藤本康雄、内山武人、北村勝彦、相澤志保子、長縄 聡、早川 智
日本薬学会, Mar. 2006, Not invited - 免疫不全ウイルスの感染における血球細胞の経時的な病態変化の解析
太田信頼、兼清 優、網 康至、相澤志保子、山本直樹、奥田研爾、本多三男
日本エイズ学会, Dec. 2005, Not invited - CD56陽性大顆粒リンパ球（CD56+LGL）細胞株MOTN-1に対するβエンドルフィンの免疫調節作用
太田郁子、鈴木美樹、相澤志保子、長縄 聡、太田啓明、千島史尚、山本樹生、早川 智
日本生殖免疫学会, Dec. 2005, Not invited - HIV-1 affects expression of transcription factors and up-regulates indoleamine 2,3 dioxygenase in large granular lymphocyte cell lines.
Komine-Aizawa S; Hayakawa S; Naganawa S; Kitamura K; Honda M
American Society for Reproductive Immunology, Jun. 2005, Not invited - HIVはdendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN)を介して樹状細胞に免疫抑制因子を誘導する
小峯志保子、早川 智、川口里恵、田中忠夫
日本産科婦人科学会, Apr. 2005, Not invited - 脱落膜リンパ球に対するHIVの感染機構．
早川 智、長縄 聰、渡邊望生、北村勝彦、小峯志保子、本多三男
日本免疫学会, Dec. 2003, Not invited - 卵巣癌Second line chemotherapy としてのDocetaxel+Adryamycinのweekly療法(WDA)のPhase II検討
高見毅司、坂元秀樹、小峯志保子、松永竜也、菊池 淳、高見紀子、千島史尚、早川 智、山本樹生
日本産科婦人科学会, Apr. 2003, Not invited - An experimental model of transplacental SHIV infection in cynomolgus monkeys.
Komine S; Hayakawa S; Sugita K; Karasaki-Suzuki M; Chisima F; Yamamoto T; Nakasone T; Izumi Y; Ami Y; Honda M
An experimental model of transplacental SHIV infection in cynomolgus monkeys., Jun. 2002, Not invited - 妊娠カニクイザルに接種したHIV/SIVキメラウイルスの動態
小峯志保子、早川 智、鈴木(唐崎)美喜、山本樹生、仲宗根正、泉 泰之、網 康至、本多三男、西成田進
日本生殖免疫学会, Dec. 2001, Not invited
Affiliated academic society
Research Themes
- Analysis of COVID-19 infection in pregnant women.
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2022 - 31 Mar. 2025
早川 智; 相澤 志保子; 山田 秀人; 川名 敬; 高田 和秀; 木村 正; TRINH DUYQUANG - Study on mechanisms of rubella virus infection to the fetus, possible alternative cellular receptors and factors affecting the virus infection
日本学術振興会, 科学研究費助成事業, 01 Apr. 2020 - 31 Mar. 2023
TRINH DUYQUANG; 早川 智; 相澤 志保子 - Elucidation of lethal intravascular hemolysis mechanism in Clostridium perfringens sepsis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2017 - 31 Mar. 2022
SUZAKI Ai - Novel COVID-19 vaccine development by recombinant BCG and DNA vaccine prime-boost immunization
公益財団法人 日本ワックスマン財団, 学術研究助成金, Apr. 2021 - Mar. 2022 - 抗酸菌の防御における細胞性免疫応答の解析と新規ワクチン開発
Apr. 2019 - Mar. 2022
相澤志保子 - Molecular backgrounds of transplacental Zika fever infection.
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2017 - 31 Mar. 2021
HAYAKAWA Satoshi - Development of novel recombinant BCG vaccine and its immunological analysis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2017 - 31 Mar. 2020
HONDA Mitsuo - 非結核性抗酸菌防御能に優れた組換えBCGワクチンの開発
Apr. 2017 - Mar. 2020
本多三男 - Influence of the mucosal immune response to the vaginal bacterial flora on HIV infection
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2016 - 31 Mar. 2019
TRINH DuyQuang - 結核を中心とした感染制御のための新規ワクチン開発と免疫学的評価
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2016 - 2018
AIZAWA Shihoko - 結核を中心とした感染制御のための新規ワクチン開発と免疫学的評価
日本大学, 平成28年度 学術研究助成金（総合研究）, Apr. 2016 - Mar. 2017 - Analysis of placental barrier functions for intra uterine viral infections
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2016
HAYAKAWA Satoshi; USHIJIMA Hiroshi; HONDA Mitsuo; AIZAWA Shihoko - A study on oral carcinogenesis and chronic inflammation
Nihon University School of Medicine Hagihara Fund Research Grant, Apr. 2015 - Mar. 2016
相澤志保子 - 粘膜炎症における古細菌の関与
公益財団法人万有生命科学振興国際交流財団, Banyu Foundation Research Grant 2013 女性研究者支援, Jan. 2014 - Dec. 2015
Shihoko Aizawa - アロ免疫によるマウス流産モデルに対する免疫学的介入の研究
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2012 - 2014
AIZAWA Shihoko; HAYAKAWA Satoshi - 抗結核免疫応答における加齢の影響について
日本大学医学部同窓会, 平成23年度日本大学医学部同窓会60周年記念医学症例研究助成金, Apr. 2011 - Mar. 2012 - Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2009 - 2011
HAYAKAWA Satoshi - 胎盤におけるインフルエンザウイルス感染の解析
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2009 - 2010
AIZAWA Shihoko - T cell function in ulcerative colitis, particularly relationship between osteopontin and ulcerative colitis
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2008 - 2010
MASUDA Hideki; HAYAKAWA Satoshi; TAKAHASHI Yasuo; AIZAWA Shihoko - Role of local decidual large granular luphocytes and local immune responses on materno-fetal HIV transmission
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2005 - 2008
HAYAKAWA Satoshi; HONDA Mitsuo; NAGANAWA Satoshi; NEMOTO Norimichi; KITAMURA Katsuhiko; SAITOH Shigeru; YAMAMOTO Naoki; INABA Noriyuki; AIZAWA Shihoko; IZUMI Yasuyuki
