Shimon Ohtake
| School of Medicine Department of Medicine | Assistant Professor |
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Paper
- ★CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice.
Shimon Otake; Tomoyuki Sasaki; Toshiaki Shirai; Nagaharu Tsukiji; Shogo Tamura; Katsuhiro Takano; Yukio Ozaki; Katsue Suzuki-Inoue
Journal of thrombosis and haemostasis : JTH, Mar. 2021 - ★One percent chlorhexidine-alcohol for preventing central venous catheter-related infection during intensive chemotherapy for patients with haematologic malignancies.
Shimon Ohtake; Hiromichi Takahashi; Masaru Nakagawa; Yoshihito Uchino; Katsuhiro Miura; Noriyoshi Iriyama; Tomohiro Nakayama; Yoshihiro Hatta; Masami Takei
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Jul. 2018 - Topological importance of CD8+ T-cell enrichment in the tumor microenvironment of classic Hodgkin lymphoma.
Hiromichi Takahashi; Shun Ito; Yoko Nakanishi; Katsuhiro Miura; Haruna Nishimaki; Masaru Nakagawa; Shimon Otake; Takashi Hamada; Takashi Koike; Kazuhide Iizuka; Shinobu Masuda; Tomohiro Nakayama; Tetsuo Shimizu; Naoya Ishibashi; Hirofumi Kogure; Hideki Nakamura
Annals of hematology, Jan. 2025 - TAFRO Syndrome: Guidance for Managing Patients Presenting Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly.
Katsuhiro Miura; Haruna Nishimaki-Watanabe; Hiromichi Takahashi; Masaru Nakagawa; Shimon Otake; Takashi Hamada; Takashi Koike; Kazuhide Iizuka; Yuuichi Takeuchi; Kazuya Kurihara; Toshihide Endo; Shun Ito; Hironao Nukariya; Takahiro Namiki; Yoshiyuki Hayashi; Hideki Nakamura
Biomedicines, Jun. 2024 - Pulmonary Veno-Occlusive Disease after Autologous Stem Cell Transplantation.
Takashi Hamada; Hiromichi Takahashi; Masaru Nakagawa; Hironao Nukariya; Shun Ito; Toshihide Endo; Kazuya Kurihara; Takashi Koike; Kazuhide Iizuka; Shimon Ohtake; Takashi Ichinohe; Toshiya Maebayashi; Katsuhiro Miura; Yoshihiro Hatta; Hideki Nakamura
Case reports in oncology, 2023 - Ideal dose intensity of R-CHOP in diffuse large B-cell lymphoma.
Katsuhiro Miura; Hiromichi Takahashi; Masaru Nakagawa; Takashi Hamada; Yoshihito Uchino; Kazuhide Iizuka; Shimon Ohtake; Noriyoshi Iriyama; Yoshihiro Hatta; Hideki Nakamura
Expert review of anticancer therapy, Jun. 2022 - 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割
大石 沙織; 築地 長治; 大竹 志門; 大石 直輝; 佐々木 知幸; 白井 俊光; 吉川 佑莉; 高野 勝弘; 新森 英之; 犬飼 岳史; 近藤 哲夫; 井上 克枝
日本血栓止血学会誌, May 2021 - Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ
Saori Oishi; Nagaharu Tsukiji; Shimon Otake; Naoki Oishi; Tomoyuki Sasaki; Toshiaki Shirai; Yuri Yoshikawa; Katsuhiro Takano; Hideyuki Shinmori; Takeshi Inukai; Tetsuo Kondo; Katsue Suzuki-Inoue
Blood Advances, Apr. 2021 - ヘミンはCLEC-2とGPVI/FcRγを介して血小板を活性化し、横紋筋融解による急性腎障害を悪化させる
大竹 志門; 大石 沙織; 築地 長治; 大石 直輝; 佐々木 知幸; 白井 俊光; 高野 勝弘; 近藤 哲夫; 井上 克枝
日本透析医会雑誌, Apr. 2021, Refereed, Not invited - 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割
大石 沙織; 築地 長治; 大竹 志門; 大石 直輝; 佐々木 知幸; 白井 俊光; 吉河 佑莉; 高野 勝弘; 近藤 哲夫; 井上 克枝
日本血栓止血学会誌, May 2020 - Crosstalk between hemostasis and lymphangiogenesis.
Katsue Suzuki-Inoue; Nagaharu Tsukiji; Shimon Otake
Journal of thrombosis and haemostasis : JTH, Apr. 2020 - Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction.
Nagaharu Tsukiji; Osamu Inoue; Mitsuru Morimoto; Norifumi Tatsumi; Hiroaki Nagatomo; Koji Ueta; Toshiaki Shirai; Tomoyuki Sasaki; Shimon Otake; Shogo Tamura; Toshiaki Tachibana; Masataka Okabe; Masanori Hirashima; Yukio Ozaki; Katsue Suzuki-Inoue
Blood, Sep. 2018, Refereed, Not invited - 少量pomalidomideでstringent complete responseに到達した多発性骨髄腫
遠藤聖英; 濱田高志; 大竹志門; 中川 優; 内野慶人; 高橋宏通; 三浦勝浩; 入山規良; 小池 隆; 栗原一也; 佐藤紘子; 八田善弘; 武井正美
臨床血液, May 2018, Refereed, Not invited - Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis
T. Sasaki; T. Shirai; N. Tsukiji; S. Otake; S. Tamura; J. Ichikawa; M. Osada; K. Satoh; Y. Ozaki; K. Suzuki-Inoue
Journal of Thrombosis and Haemostasis, May 2018, Refereed, Not invited - [Achievement of a stringent complete response with low-dose pomalidomide monotherapy in a multiple myeloma patient].
Toshihide Endo; Takashi Hamada; Shimon Otake; Masaru Nakagawa; Yshihito Uchino; Hiromichi Takahashi; Katsuhiro Miura; Noriyoshi Iriyama; Takashi Koike; Kazuya Kurihara; Hiroko Sato; Yoshihiro Hatta; Msamai Takei
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2018 - Clinical effect of immunophenotyping on the prognosis of multiple myeloma patients treated with bortezomib.
Noriyoshi Iriyama; Katsuhiro Miura; Yoshihiro Hatta; Sumiko Kobayashi; Yoshihito Uchino; Daisuke Kurita; Hitomi Sakagami; Hiromichi Takahashi; Masashi Sakagami; Yujin Kobayashi; Masaru Nakagawa; Shimon Ohtake; Yoshikazu Iizuka; Masami Takei
Oncology letters, May 2017 - Negative impact of concurrent overexpression of MYC and BCL2 in patients with advanced diffuse large B-cell lymphoma treated with dose-intensified immunochemotherapy.
Hiromichi Takahashi; Katsuhiro Miura; Masaru Nakagawa; Masahiko Sugitani; Yusuke Amano; Daisuke Kurita; Masashi Sakagami; Shimon Ohtake; Yoshihito Uchino; Hitomi Kodaira; Noriyoshi Iriyama; Sumiko Kobayashi; Atsuko Hojo; Yujin Kobayashi; Yukio Hirabayashi; Machiko Kusuda; Yoshihiro Hatta; Tomohiro Nakayama; Masami Takei
Leukemia & lymphoma, Dec. 2016 - A cyclin D1-negative mantle cell lymphoma with an IGL-CCND2 translocation that relapsed with blastoid morphology and aggressive clinical behavior.
Daisuke Kurita; Kengo Takeuchi; Sumiko Kobayashi; Atsuko Hojo; Yoshihito Uchino; Masashi Sakagami; Shimon Ohtake; Hiromichi Takahashi; Katsuhiro Miura; Noriyoshi Iriyama; Masahiko Sugitani; Hiroaki Miyoshi; Yoshihiro Hatta; Koichi Ohshima; Masami Takei
Virchows Archiv : an international journal of pathology, Oct. 2016 - Plasma cell maturity as a predictor of prognosis in multiple myeloma.
Noriyoshi Iriyama; Katsuhiro Miura; Yoshihiro Hatta; Yoshihito Uchino; Daisuke Kurita; Hiromichi Takahashi; Hitomi Sakagami; Masashi Sakagami; Yujin Kobayashi; Masaru Nakagawa; Shimon Ohtake; Yoshikazu Iizuka; Masami Takei
Medical oncology (Northwood, London, England), Aug. 2016 - Clinical efficacy and safety of arbekacin for high-risk infections in patients with hematological malignancies.
Katsuhiro Miura; Masaru Nakagawa; Hiromichi Takahashi; Yoshihito Uchino; Hitomi Kodaira; Noriyoshi Iriyama; Masashi Sakagami; Shimon Ohtake; Sumiko Kobayashi; Atsuko Hojo; Daisuke Kurita; Yujin Kobayashi; Machiko Kusuda; Yukio Hirabayashi; Yoshihiro Hatta; Masami Takei
International journal of hematology, Mar. 2016 - Clinical significance of co-expression of MYC and BCL2 protein in aggressive B-cell lymphomas treated with a second line immunochemotherapy.
Katsuhiro Miura; Hiromichi Takahashi; Masaru Nakagawa; Asami Izu; Masahiko Sugitani; Daisuke Kurita; Masashi Sakagami; Shimon Ohtake; Yoshihito Uchino; Atsuko Hojo; Hitomi Kodaira; Mai Yagi; Yujin Kobayashi; Noriyoshi Iriyama; Sumiko Kobayashi; Satomi Kiso; Yukio Hirabayashi; Yoshihiro Hatta; Masami Takei
Leukemia & lymphoma, 2016 - Dose-intensified CHOP with rituximab (R-Double-CHOP) followed by consolidation high-dose chemotherapies for patients with advanced diffuse large B-cell lymphoma.
Daisuke Kurita; Katsuhiro Miura; Masaru Nakagawa; Shimon Ohtake; Masashi Sakagami; Yoshihito Uchino; Hiromichi Takahashi; Satomi Kiso; Atsuko Hojo; Hitomi Kodaira; Mai Yagi; Yukio Hirabayashi; Yujin Kobayashi; Noriyoshi Iriyama; Sumiko Kobayashi; Yoshihiro Hatta; Yoshimasa Kura; Masahiko Sugitani; Masami Takei
International journal of hematology, Jun. 2015
MISC
- Clinical Significance of Co-Expression of MYC and BCL2 Protein in Advanced Diffuse Large B-Cell Lymphoma Treated with a Dose-Intensified Immunochemotherapy
Hiromichi Takahashi; Sumiko Kobayashi; Katsuhiro Miura; Daisuke Kurita; Yoshihiro Hatta; Masahiko Sugitani; Shimon Otake; Masaru Nakagawa; Masashi Sakagami; Yoshihito Uchino; Hitomi Kodaira; Noriyoshi Iriyama; Machiko Kusuda; Atsuko Hojo; Mai Yagi; Yukio Hirabayashi; Yujin Kobayashi; Tomohiro Nakayama; Masami Takei
BLOOD, Dec. 2015, Not refereed, Not invited - Clinical Significance of Arbekacin Sulfate for High-Risk Infections Among Patients with Hematological Malignancies
Katsuhiro Miura; Satomi Kiso; Masaru Nakagawa; Hiromichi Takahashi; Yoshito Uchino; Hitomi Kodaira; Noriyoshi Iriyama; Masashi Sakagami; Shimon Ohtake; Sumiko Kobayashi; Atsuko Hojo; Mai Yagi; Daisuke Kurita; Yujin Kobayashi; Machiko Kusuda; Yukio Hirabayashi; Yoshihiro Hatta; Masami Takei
BLOOD, Dec. 2014, Not refereed, Not invited
Lectures, oral presentations, etc.
- Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis
S. Otake; T. Shirai; N. Tsukiji; T. Sasaki; K. Satoh; S. Tamura; K. Takano; Y. Ozaki; K. Suzuki-Inoue
ISTH2019, Jul. 2019, International Society on Thrombosis and Haemostasis (ISTH), Not invited - Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury
N. Tsukiji; S. Oishi; S. Otake; T. Sasaki; K. Takano; K. Suzuki-Inoue
ISTH2019, Jul. 2019, International Society on Thrombosis and Haemostasis, Not invited - 血小板・巨核球上のC型レクチン様受容体（CLEC-2）が、赤血球造血に及ぼす役割
大竹志門; 白井俊光; 築地長治; 佐々木知幸; 田村彰吾; 尾崎由基男; 井上克枝
第41回日本血栓止血学会学術集会, Jun. 2019, 一般社団法人 日本血栓止血学会, Not invited - ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与
築地長治; 大竹志門; 佐々木知幸; 吉河佑莉; 高野勝弘; 井上克枝
第41回日本血栓止血学会学術集会, Jun. 2019, 一般社団法人 日本血栓止血学会, Not invited - Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesis
Shimon Otake; Toshiaki Shirai; Nagaharu Tsukiji; Tomoyuki Sasaki; Kaneo Satoh; Shogo Tamura; Yukio Ozaki; Katsue Suzuki-Inoue
The 80th Annual Meeting of the Japanese Society of Hematology, Oct. 2018, 一般社団法人 日本血液学会, Not invited - GPVI依存性血小板凝集を惹起する蛇毒コンバルキシンの遺伝子組換え体の作製と機能解析
佐々木知幸; 白井俊光; 築地長治; 大竹志門; 田村彰吾; 長田誠; 佐藤金夫; 尾崎由基男; 井上克枝
第91回日本生化学会大会, Sep. 2018, 公益社団法人 日本生化学会, Not invited - 血小板・巨核球上のC型レクチン様受容体（CLEC-2)が、赤芽球の分化、成熟に及ぼす影響
大竹志門; 白井俊光; 築地長治; 佐々木知幸; 田村彰吾; 佐藤金夫; 尾崎由基男; 井上克枝
第40回日本血栓止血学会学術集会, Jun. 2018, 一般社団法人 日本血栓止血学会, Not invited - 血小板受容体GPVIアゴニスト蛇毒コンバルキシンの遺伝組換体の作製とその機能解析
佐々木知幸; 白井俊光; 築地長治; 大竹志門; 田村彰吾; 長田誠; 佐藤金夫; 尾崎由基男; 井上克枝
第40回日本血栓止血学会学術集会, Jun. 2018, 一般社団法人 日本血栓止血学会, Not invited - 脳梗塞の増悪因子であるアクロレインの抗血小板作用
梅谷徳彦; 白井俊光; 築地長治; 佐々木知幸; 田村彰吾; 佐藤金夫; 大竹志門; 高野勝弘; 横道洋司; 尾崎由基男; 井上克枝
第40回日本血栓止血学会学術集会, Jun. 2018, 一般社団法人 日本血栓止血学会, Not invited - Platelets as a novel key player in organogenesis: Clec-2/podoplanin interaction regulates fetal lung development
Nagaharu Tsukiji; Osamu Inoue; Mitsuru Morimoto; Norifumi Tatsumi; Hiroaki Nagatomo; Koji Ueta; Toshiaki Shirai; Tomoyuki Sasaki; Shimon Otake; Shogo Tamura; Toshiaki Tachibana; Masataka Okabe; Masanori Hirashima; Yukio Ozaki; Katsue Suzuki-Inoue
The 40th Congress of the Japanese Society on Thrombosis and Hemostasis, Jun. 2018, 一般社団法人 日本血栓止血学会, Not invited - 血小板・巨核球上のC型レクチン様受容体（CLEC-2)が赤血球造血に及ぼす役割
大竹志門; 白井俊光; 築地長治; 佐々木知幸; 田村彰吾; 佐藤金夫; 尾崎由基男; 井上克枝
第79回日本血液学会学術集会, Oct. 2017, 一般社団法人 日本血液学会, Not invited
Affiliated academic society
Research Themes
- Elucidation of the roles of platelet in hepatic sinusoidal obstruction syndrome and basic studies for clinical application
日本大学, 日本大学医学部同窓会60周年記念医学奨励基金研究助成金, Apr. 2024 - Mar. 2025 - 抗CD20抗体治療後の腸内細菌叢に対するプロバイオティクスの影響分析
ヤクルト・バイオサイエンス研究財団, 一般研究助成, Apr. 2024 - Mar. 2025 - 肝類洞閉塞症候群における血小板活性化受容体CLEC-2の役割解明
日本学術振興会, 科学研究費助成事業 若手研究, 01 Apr. 2021 - 31 Mar. 2024
大竹 志門 - 肝類洞閉塞症候群における，血小板活性化受容体 CLEC-2 の役割解明
日本血液学会, 日本血液学会研究助成, Apr. 2023 - Mar. 2024 - 血小板活性化受容体CLEC-2を標的とした抗体医薬の開発とその薬理作用の解明
日本学術振興会, 科学研究費助成事業, 01 Apr. 2020 - 31 Mar. 2023
佐々木 知幸; 井上 克枝; 築地 長治; 白井 俊光; 大竹 志門 - 肝類洞閉塞症候群における血小板活性化受容体CLEC-2の役割の解明
一般社団法人 日本血液学会, 日本血液学会研究助成事業, 01 Apr. 2020 - 31 Mar. 2021
大竹 志門 - 赤血球造血における血小板活性化受容体CLEC-2の役割の解明
独立行政法人 日本学術振興会, 科学研究費助成事業, Apr. 2018 - Mar. 2021
大竹 志門 - 横紋筋融解症による急性腎障害における、血小板活性化受容体CLEC-2の役割の解明
公益社団法人 日本透析医会, 日本透析医会公募研究助成, 01 Apr. 2019 - 31 Mar. 2020
大竹 志門 - 血小板活性化受容体 CLEC-2 が正常腎発生とその機能維持に果たす役割の解明
一般社団法人 日本血液学会, 日本血液学会研究助成事業, 01 Apr. 2019 - 31 Mar. 2020
大竹 志門 - 横紋筋融解症による急性腎障害発症における、血小板活性化受容体C-type lectin like receptor 2 (CLEC-2)の役割
一般社団法人 日本血液学会, 日本血液学会研究助成事業, 01 Apr. 2018 - 31 Mar. 2019
大竹 志門 - 血小板・巨核球上のC型レクチン様受容体 C-type lectin-like receptor 2 (CLEC-2)の、赤血球造血における役割：赤血球造血と血小板造血のクロストーク
一般社団法人 日本血液学会, 日本血液学会研究助成事業, 01 Apr. 2017 - 31 Mar. 2018
大竹 志門 - The roles of CLEC-2 in lymphangiogenesis at the sites of inflammation
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 01 Apr. 2014 - 31 Mar. 2017
INOUE Osamu; OOTAKE Shimon
