HAYASHI Yoshinori
| School of Dentistry Department of Dentistry | Associate Professor |
Researcher Information
Field Of Study
Career
- Oct. 2020 - Present
Nihon University, School of Dentistry, 准教授 - Jun. 2023 - Feb. 2024
The University of Alabama at Birmingham, Department of Anesthesiology, Research Scholar - Apr. 2019 - Sep. 2020
Nihon University, School of Dentistry, 助教 - Jun. 2016 - Mar. 2019
Kyushu University, School of Dentistry, 講師 - Apr. 2010 - May 2016
Kyushu University, School of Dentistry, 助教 - Apr. 2007 - Mar. 2010
日本学術振興会 特別研究員(DC1)
Educational Background
Research activity information
Award
- Aug. 2024
日本口腔外科学会, 第6回若手口腔外科医優秀論文賞
大島絵莉(指導学生) - Nov. 2023
FAOPS2023, Best Research Award The 10th Federation of the Asian and Oceanian Physiological Societies Congress
大島絵莉(指導学生) - Nov. 2023
日本口腔顔面痛学会, 最優秀ポスター賞
池端陽介(指導学生) - Sep. 2023
歯科基礎医学会, 第65回歯科基礎医学会学術大会モリタ優秀発表賞
大島絵莉(指導学生) - Aug. 2023
第18回先端歯学スクール2023優秀賞
大島絵莉(指導学生) - Nov. 2022
日本口腔顔面痛学会, 優秀ポスター賞
尾辻盛(指導学生) - Nov. 2021
日本口腔顔面痛学会, 最優秀ポスター賞
木村有貴 - 8th Asian Pain Symposium, Outstanding Research Award
Yoshinori Hayashi - 第56回歯科基礎医学会, 第26回歯科基礎医学会賞
林 良憲 - Purine 2012, Purine 2012 Poster Award
林 良憲 - 歯科基礎医学会, 第53回歯科基礎医学会学術大会・総会 優秀ポスター発表賞
林 良憲 - 内藤記念科学振興財団, 第29回内藤コンファレンス Poster Award
林 良憲 - 九州大学歯学部, 藤野博賞
林 良憲 - 日本薬理学会, 第62回日本薬理学会西南部会優秀発表賞
林 良憲 - 日本薬理学会年会, 第81回日本薬理学会年会優秀発表賞
林 良憲
Paper
- P2Y12 Signaling in Muscle Satellite Cells Contributes to Masseter Muscle Contraction-induced Pain.
Sho Sawada; Suzuro Hitomi; Yoshinori Hayashi; Kenji Yoshikawa; Fumitaka Yagasaki; Hirotaka Shinozuka; Yoshiyuki Yonehara; Yoshiyuki Tsuboi; Koichi Iwata; Masamichi Shinoda
The journal of pain, Mar. 2025 - Role of trigeminal ganglion satellite glial cells in masseter muscle pain hypersensitivity
Sho Sawada; Suzuro Hitomi; Yoshinori Hayashi; Hirotaka Shinozuka; Yoshiyuki Yonehara; Koichi Iwata; Masamichi Shinoda
Journal of Oral Biosciences, Dec. 2024, Refereed, Not invited - Hepcidin promote oral ulcer healing via amphiregulin production in rats
Naoto Taguchi; Suzuro Hitomi; Hioshi Sato; Yoshinori Hayashi; Ikuko Shibuta; Koichi Iwata; Tatsuo Shirota; Masamichi Shinoda
Journal of Dental Sciences, Dec. 2024, Refereed, Not invited - Fibroblast-derived IL-33 exacerbates orofacial neuropathic pain via the activation of TRPA1 in trigeminal ganglion neurons
Yousuke Ikehata; Eri Oshima; Yoshinori Hayashi; Yukinori Tanaka; Hitoshi Sato; Suzuro Hitomi; Miho Shiratori-Hayashi; Kentaro Urata; Yuki Kimura; Ikuko Shibuta; Seigo Ohba; Koichi Iwata; Kentaro Mizuta; Tatsuo Shirota; Masamichi Shinoda
Brain, Behavior, and Immunity, Nov. 2024, Refereed, Not invited
Corresponding - Ageing‐Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain
Kentaro Urata; Tatsuki Oto; Yoshinori Hayashi; Suzuro Hitomi; Takayuki Ikeda; Koichi Iwata; Toshimitsu Iinuma; Masamichi Shinoda
Oral Diseases, Oct. 2024, Refereed, Not invited - Non-neuronal cells act as crucial players in neuropathic orofacial pain
Koichi Iwata; Yoshinori Hayashi; Suzuro Hitomi; Yoshiyuki Tsuboi; Masamichi Shinoda
Journal of Oral Biosciences, Jul. 2024, Refereed, Not invited - Involvement of oxidative stress in orofacial mechanical pain hypersensitivity following neonatal maternal separation in rats.
Chihiro Soma; Suzuro Hitomi; Eri Oshima; Yoshinori Hayashi; Kumi Soma; Ikuko Shibuta; Yoshiyuki Tsuboi; Tetsuo Shirakawa; Takashi Kikuiri; Koichi Iwata; Masamichi Shinoda
Scientific reports, Dec. 2023, Refereed - Analgesic effect of linalool odor on oral ulcerative mucositis-induced pain in rats.
Masato Iida; Suzuro Hitomi; Yoshinori Hayashi; Ikuko Shibuta; Yoshiyuki Tsuboi; Koichiro Ueda; Koichi Iwata; Masamichi Shinoda
Brain research bulletin, Dec. 2023, Refereed - M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
Eri Oshima; Yoshinori Hayashi; Zhen Xie; Hitoshi Sato; Suzuro Hitomi; Ikuko Shibuta; Kentaro Urata; Junjun Ni; Koichi Iwata; Tatsuo Shirota; Masamichi Shinoda
Journal of Neuroinflammation, Nov. 2023, Refereed, Not invited
Corresponding - PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain
Ryuta Akasaka; Akihiko Furukawa; Yoshinori Hayashi; Suzuro Hitomi; Ryo Koyama; Eri Oshima; Miki Tamura; Mamiko Yonemoto; Yasushi Hojo; Ryosuke Takahashi; Ikuko Shibuta; Koichi Iwata; Yoshiyuki Yonehara; Masamichi Shinoda
Journal of Oral Biosciences, Oct. 2023, Refereed, Not invited
Corresponding - Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke
Takashi Irie; Taito Matsuda; Yoshinori Hayashi; Kanae Matsuda-Ito; Akihide Kamiya; Takahiro Masuda; Marco Prinz; Noriko Isobe; Jun-ichi Kira; Kinichi Nakashima
PNAS, Oct. 2023, Refereed, Not invited - Zinc finger protein 335 mediates lipopolysaccharide‐induced neurodegeneration and memory loss as a transcriptional factor in microglia
Wei Kong; Zhen Xie; Xiaokang Shang; Yoshinori Hayashi; Fei Lan; Narengaowa; Shuxuan Zhao; Hui Li; Zhenzhen Quan; Zhou Wu; Hiroshi Nakanishi; Hong Qing; Junjun Ni
Glia, Jul. 2023, Refereed, Not invited - Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats
Yoshinori Hayashi; Jo Otsuji; Eri Oshima; Suzuro Hitomi; Junjun Ni; Kentaro Urata; Ikuko Shibuta; Koichi Iwata; Masamichi Shinoda
Brain, Behavior, & Immunity - Health, Apr. 2023, Refereed
Lead - Neonatal injury modulates incisional pain sensitivity in adulthood: An animal study
Kumi Soma; Suzuro Hitomi; Yoshinori Hayashi; Chihiro Soma; Jo Otsuji; Ikuko Shibuta; Akihiko Furukawa; Kentaro Urata; Ryoko Kurisu; Mamiko Yonemoto; Yasushi Hojo; Tetsuo Shirakawa; Koichi Iwata; Masamichi Shinoda
Neuroscience, Mar. 2023, Refereed, Not invited - Age-related Changes in Trigeminal Ganglion Macrophages Enhance Orofacial Ectopic Pain After Inferior Alveolar Nerve Injury
SHINTARO FUJIWARA; KENTARO URATA; TATSUKI OTO; YOSHINORI HAYASHI; SUZURO HITOMI; KOICHI IWATA; TOSHIMITSU IINUMA; MASAMICHI SHINODA
In Vivo, Jan. 2023, Refereed, Not invited - Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats
Jo Otsuji; Yoshinori Hayashi; Suzuro Hitomi; Chihiro Soma; Kumi Soma; Ikuko Shibuta; Koichi Iwata; Tetsuo Shirakawa; Masamichi Shinoda
Scientific Reports, Nov. 2022, Refereed, Not invited
Corresponding - Astrocytic and microglial interleukin-1b mediates complement C1q-triggered orofacial mechanical allodynia
Chaoli Hong; Yoshinori Hayashi; Suzuro Hitomi; Ryoko Kurisu; Kentaro Urata; Ikuko Shibuta; Akira Toyofuku; Koichi Iwata; Masamichi Shinoda
Neuroscience Research, Nov. 2022, Refereed, Not invited
Corresponding - Plastic changes in nociceptive pathways contributing to persistent orofacial pain.
Masamichi Shinoda; Suzuro Hitomi; Koichi Iwata; Yoshinori Hayashi
Journal of oral biosciences, Sep. 2022 - 口腔顔面の病的痛みに対する非神経細胞-神経細胞機能連関の役割
林 良憲; 岩田 幸一; 人見 涼露; 篠田 雅路
日本頭痛学会誌, Sep. 2022 - Age-Related Differences in Transient Receptor Potential Vanilloid 1 and 2 Expression Patterns in the Trigeminal Ganglion Neurons Contribute to Changes in the Palatal Mucosal Heat Pain Sensitivity.
Tatsuki Oto; Kentaro Urata; Yoshinori Hayashi; Suzuro Hitomi; Ikuko Shibuta; Koichi Iwata; Toshimitsu Iinuma; Masamichi Shinoda
The Tohoku journal of experimental medicine, Apr. 2022, Refereed - The Dual Nature of Microglia in Alzheimer’s Disease: A Microglia-Neuron Crosstalk Perspective
Zhen Xie; Jie Meng; Zhou Wu; Hiroshi Nakanishi; Yoshinori Hayashi; Wei Kong; Fei Lan; Narengaowa; Qinghu Yang; Hong Qing; Junjun Ni
The Neuroscientist, Mar. 2022 - Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia
Erika Sugisawa; Takeshi Kondo; Yutaro Kumagai; Hiroki Kato; Yasunori Takayama; Kayako Isohashi; Eku Shimosegawa; Naoki Takemura; Yoshinori Hayashi; Takuya Sasaki; Mikaël M. Martino; Makoto Tominaga; Kenta Maruyama
Cell Reports, Mar. 2022, Refereed, Not invited - Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease
Zhen Xie; Jie Meng; Wei Kong; Zhou Wu; Fei Lan; Narengaowa; Yoshinori Hayashi; Qinghu Yang; Zhantao Bai; Hiroshi Nakanishi; Hong Qing; Junjun Ni
Aging Cell, Feb. 2022, Refereed - Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury‐induced mechanical allodynia
Ryoko Kurisu; Tadashi Saigusa; Yuri Aono; Yoshinori Hayashi; Suzuro Hitomi; Masahiko Shimada; Koichi Iwata; Masamichi Shinoda
Oral Diseases, Jan. 2022, Refereed, Not invited - IL-33 induces orofacial neuropathic pain through Fyn-dependent phosphorylation of GluN2B in the trigeminal spinal subnucleus caudalis
Yuki Kimura; Yoshinori Hayashi; Suzuro Hitomi; Daisuke Ikutame; Kentaro Urata; Ikuko Shibuta; Atsushi Sakai; Junjun Ni; Koichi Iwata; Morio Tonogi; Masamichi Shinoda
Brain, Behavior, and Immunity, Jan. 2022, Refereed, Not invited
Corresponding - Stem cells from human exfoliated deciduous teeth attenuate mechanical allodynia in mice through distinct from the siglec-9/MCP-1-mediated tissue-repairing mechanism
Yoshinori Hayashi; Hiroki Kato; Kazuaki Nonaka; Hiroshi Nakanishi
Scientific Reports, Dec. 2021, Refereed
Lead - Differential Expression and Distinct Roles of Proteinase-Activated Receptor 2 in Microglia and Neurons in Neonatal Mouse Brain After Hypoxia-Ischemic Injury
Yicong Liu; Hui Li; Jiangqi Hu; Zhou Wu; Jie Meng; Yoshinori Hayashi; Hiroshi Nakanishi; Hong Qing; Junjun Ni
Molecular Neurobiology, Nov. 2021, Refereed, Not invited - Periodontal acidification contributes to tooth pain hypersensitivity during orthodontic tooth movement
Ayaka Osada; Suzuro Hitomi; Akira Nakajima; Yoshinori Hayashi; Ikuko Shibuta; Yoshiyuki Tsuboi; Mitsuru Motoyoshi; Koichi Iwata; Masamichi Shinoda
Neuroscience Research, Nov. 2021, Refereed, Not invited - 脳・脊髄、関節、骨・椎間板に関する基礎研究Update 口腔顔面痛の新たなメカニズム
人見 涼露; 岩田 幸一; 林 良憲; 篠田 雅路
Journal of Musculoskeletal Pain Research, Oct. 2021 - Effect of low‐intensity pulsed ultrasound on orofacial sensory disturbance following inferior alveolar nerve injury: Role of neurotrophin‐3 signaling
Akane Tsuchimochi; Chitose Endo; Mitsuru Motoyoshi; Miki Tamura; Suzuro Hitomi; Yoshinori Hayashi; Masamichi Shinoda
European Journal of Oral Sciences, Oct. 2021, Refereed, Not invited - Pannexin 1-mediated ATP signaling in the trigeminal spinal subnucleus caudalis is involved in tongue cancer pain
Ryo Koyama; Koichi Iwata; Yoshinori Hayashi; Suzuro Hitomi; Ikuko Shibuta; Akihiko Furukawa; Sayaka Asano; Tadayoshi Kaneko; Yoshiyuki Yonehara; Masamichi Shinoda
International Journal of Molecular Sciences, Oct. 2021, Refereed, Not invited
Corresponding - Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke
Takashi Irie; Taito Matsuda; Yoshinori Hayashi; Akihide Kamiya; Jun-ichi Kira; Kinichi Nakashima
bioRxiv, Sep. 2021 - Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies
Masamichi Shinoda; Yoshiki Imamura; Yoshinori Hayashi; Noboru Noma; Akiko Okada-Ogawa; Suzuro Hitomi; Koichi Iwata
Frontiers in Molecular Neuroscience, Jul. 2021, Refereed, Not invited - Rapamycin accelerates axon regeneration through Schwann cell-mediated autophagy following inferior alveolar nerve transection in rats
Takanobu Inada; Hitoshi Sato; Yoshinori Hayashi; Suzuro Hitomi; Akihiko Furukawa; Masatoshi Ando; Eri Oshima; Jo Otsuji; Naoto Taguchi; Ikuko Shibuta; Hiromasa Tsuda; Koichi Iwata; Tatsuo Shirota; Masamichi Shinoda
Neuroscience, Jun. 2021, Refereed, Not invited
Corresponding - 三叉神経系における侵害受容の分子メカニズムと病態変化
篠田 雅路; 林 良憲; 人見 涼露; 岩田 幸一
日本頭痛学会誌, Apr. 2021 - Butyric acid modulates periodontal nociception in Porphyromonas gingivalis-induced periodontitis
Naoki Murakami; Kenji Yoshikawa; Kohei Tsukada; Noriaki Kamio; Yoshinori Hayashi; Suzuro Hitomi; Yuki Kimura; Ikuko Shibuta; Ayaka Osada; Shuichi Sato; Koichi Iwata; Masamichi Shinoda
Journal of Oral Science, 2021, Refereed, Not invited - Microglial activation in the trigeminal spinal subnucleus interpolaris/caudalis modulates orofacial incisional mechanical pain hypersensitivity associated with orofacial injury in infancy
Tomoyuki Matsui; Suzuro Hitomi; Yoshinori Hayashi; Ikuko Shibuta; Jo Otsuji; Masatoshi Ando; Takanobu Inada; Kumi Soma; Koichi Iwata; Tetsuo Shirakawa; Masamichi Shinoda
Journal of Oral Science, 2021, Refereed, Not invited - P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats
Momoko Koizumi; Sayaka Asano; Akihiko Furukawa; Yoshinori Hayashi; Suzuro Hitomi; Ikuko Shibuta; Katsuhiko Hayashi; Fusao Kato; Koichi Iwata; Masamichi Shinoda
The Journal of Headache and Pain, 2021, Refereed - Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response
Hiroshi Nakanishi; Junjun Ni; Saori Nonaka; Yoshinori Hayashi
Neurochemistry International, Jan. 2021, Refereed, Not invited - Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain Following Infraorbital Nerve Injury in Rats
Masatoshi Ando; Yoshinori Hayashi; Suzuro Hitomi; Ikuko Shibuta; Akihiko Furukawa; Tatsuki Oto; Takanobu Inada; Tomoyuki Matsui; Chikashi Fukaya; Noboru Noma; Masakazu Okubo; Yoshiyuki Yonehara; Tadayoshi Kaneko; Koichi Iwata; Masamichi Shinoda
International Journal of Molecular Sciences, Dec. 2020, Refereed, Not invited - Neural stem cell–specific ITPA deficiency causes neural depolarization and epilepsy
Yuichiro Koga; Daisuke Tsuchimoto; Yoshinori Hayashi; Nona Abolhassani; Yasuto Yoneshima; Kunihiko Sakumi; Hiroshi Nakanishi; Shinya Toyokuni; Yusaku Nakabeppu
JCI Insight, Nov. 2020, Refereed, Not invited - Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity
Daisuke Ikutame; Kentaro Urata; Tatsuki Oto; Shintaro Fujiwara; Toshimitsu Iinuma; Ikuko Shibuta; Yoshinori Hayashi; Suzuro Hitomi; Koichi Iwata; Masamichi Shinoda
International Journal of Molecular Sciences, Oct. 2020, Refereed, Not invited - Microglia–Astrocyte Communication via C1q Contributes to Orofacial Neuropathic Pain Associated with Infraorbital Nerve Injury
Sayaka Asano; Yoshinori Hayashi; Koichi Iwata; Akiko Okada-Ogawa; Suzuro Hitomi; Ikuko Shibuta; Yoshiki Imamura; Masamichi Shinoda
International Journal of Molecular Sciences, Sep. 2020, Refereed, Not invited
Corresponding - Suppression of Superficial Microglial Activation by Spinal Cord Stimulation Attenuates Neuropathic Pain Following Sciatic Nerve Injury in Rats.
Masamichi Shinoda; Satoshi Fujita; Shiori Sugawara; Sayaka Asano; Ryo Koyama; Shintaro Fujiwara; Kumi Soma; Takaaki Tamagawa; Tomoyuki Matsui; Daisuke Ikutame; Masatoshi Ando; Ayaka Osada; Yuki Kimura; Kazutaka Kobayashi; Takamitsu Yamamoto; Kuniko Kusama-Eguchi; Masayuki Kobayashi; Yoshinori Hayashi; Koichi Iwata
International journal of molecular sciences, Mar. 2020 - Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity
Jun Lee; Kinuyo Ohara; Masamichi Shinoda; Yoshinori Hayashi; Asako Kubo; Shiori Sugawara; Sayaka Asano; Kumi Soma; Kohei Kanno; Masatoshi Ando; Ryo Koyama; Yuki Kimura; Kousuke Sakanashi; Toshimitsu Iinuma; Koichi Iwata
International Journal of Molecular Sciences, Feb. 2020, Refereed, Not invited - Involvement of TNFα in the enhancement of hypersensitivity in the adulthood-injured face associated with facial injury in infancy
Kumi Soma; Masamichi Shinoda; Yoshinori Hayashi; Kohei Kanno; Tetsuo Shirakwa; Koichi Iwata
Neuroscience Research, Jan. 2020, Refereed, Not invited - Pathophysiological mechanisms of persistent orofacial pain
Masamichi Shinoda; Yoshinori Hayashi; Asako Kubo; Koichi Iwata
Journal of Oral Science, 2020, Refereed, Not invited - A TLR–CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice
Jing Zhang; Yuka Harada; Yoshinori Hayashi
Scientific Reports, Dec. 2019, Refereed, Not invited
Last - Peripheral and Central Mechanisms of Persistent Orofacial Pain
Masamichi Shinoda; Asako Kubo; Yoshinori Hayashi; Koichi Iwata
Frontiers in Neuroscience, Nov. 2019, Refereed, Not invited - Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.
Yuka Harada; Jing Zhang; Kazuhisa Imari; Ryo Yamasaki; Junjun Ni; Zhou Wu; Kenji Yamamoto; Jun-Ichi Kira; Hiroshi Nakanishi; Yoshinori Hayashi
Pain, Sep. 2019, Refereed, Not invited
Last - KCNMB3 in spinal microglia contributes to the generation and maintenance of neuropathic pain in mice
Kazuhisa Imari; Yuka Harada; Jing Zhang; Yoshihide Mori; Yoshinori Hayashi
International Journal of Molecular Medicine, Jul. 2019, Refereed, Not invited
Last - Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.
Taito Matsuda; Takashi Irie; Shutaro Katsurabayashi; Yoshinori Hayashi; Tatsuya Nagai; Nobuhiko Hamazaki; Aliya Mari D Adefuin; Fumihito Miura; Takashi Ito; Hiroshi Kimura; Katsuhiko Shirahige; Tadayuki Takeda; Katsunori Iwasaki; Takuya Imamura; Kinichi Nakashima
Neuron, Feb. 2019, Refereed, Not invited - Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
Ni J; Wu Z; Stoka V; Meng J; Hayashi Y; Peters C; Qing H; Turk V; Nakanishi H
Aging cell, Feb. 2019, Refereed, Not invited - Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain
Sugawara S; Shinoda M; Hayashi Y; Saito H; Asano S; Kubo A; Shibuta I; Furukawa A; Toyofuku A; Iwata K
International Journal of Molecular Sciences, 2019, Refereed, Not invited - A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.
Takayuki Fujii; Ryo Yamasaki; Kyoko Iinuma; Daisuke Tsuchimoto; Yoshinori Hayashi; Ban-Yu Saitoh; Takuya Matsushita; Mizuho A Kido; Shinichi Aishima; Hiroshi Nakanishi; Yusaku Nakabeppu; Jun-Ichi Kira
Annals of neurology, Aug. 2018, Refereed, Not invited - Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice (vol 7, 2017)
Yicong Liu; Zhou Wu; Yurika Nakanishi; Junjun Ni; Yoshinori Hayashi; Fumiko Takayama; Yanmin Zhou; Tomoko Kadowaki; Hiroshi Nakanishi
SCIENTIFIC REPORTS, Jul. 2018, Refereed, Not invited - Enantioselective Monoclonal Antibodies for Detecting Ketamine to Crack Down on Illicit Use.
Morita I; Oyama H; Kanda Y; Yasuo M; Ito A; Toyota M; Hayashi Y; Yokoyama T; Kobayashi N
Biological and Pharmaceutical Bulletin, 2018, Refereed, Not invited - Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice
Yicong Liu; Zhou Wu; Yurika Nakanishi; Junjun Ni; Yoshinori Hayashi; Fumiko Takayama; Yanmin Zhou; Tomoko Kadawaki; Hiroshi Nakanishi
SCIENTIFIC REPORTS, Sep. 2017, Refereed, Not invited - Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice
Fumiko Takayama; Xinwen Zhang; Yoshinori Hayashi; Zhou Wu; Hiroshi Nakanishi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2017, Refereed, Not invited - Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin
Yuka Harada; Fumiko Takayama; Kazunari Tanabe; Junjun Ni; Yoshinori Hayashi; Kenji Yamamoto; Zhou Wu; Hiroshi Nakanishi
CELLULAR AND MOLECULAR NEUROBIOLOGY, Apr. 2017, Refereed, Not invited - Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y(6) receptor system
Fumiko Takayama; Yoshinori Hayashi; Zhou Wu; Yicong Liu; Hiroshi Nakanishi
SCIENTIFIC REPORTS, Jul. 2016, Refereed, Not invited - BK channels in microglia are required for morphine-induced hyperalgesia
Yoshinori Hayashi; Saori Morinaga; Jing Zhang; Yasushi Satoh; Andrea L. Meredith; Takahiro Nakata; Zhou Wu; Shinichi Kohsaka; Kazuhide Inoue; Hiroshi Nakanishi
Nature Communications, May 2016, Refereed, Not invited
Lead - An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons
Yoshinori Hayashi; Saori Morinaga; Xia Liu; Jing Zhang; Zhou Wu; Takeshi Yokoyama; Hiroshi Nakanishi
MEDIATORS OF INFLAMMATION, 2016, Refereed, Not invited
Lead - BK channel in microglia as a potent therapeutic molecular target for neuropathic pain
Yoshinori Hayashi; Hiroshi Nakanishi
Journal of Oral Biosciences, Aug. 2015, Refereed, Not invited
Lead - Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance
Y. Hayashi; Y. Koga; X. Zhang; C. Peters; Y. Yanagawa; Z. Wu; T. Yokoyama; H. Nakanishi
Neuroscience, Sep. 2014, Refereed, Not invited
Lead - Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State
X. Zhang; Z. Wu; Y. Hayashi; R. Okada; H. Nakanishi
Journal of Neuroscience, Feb. 2014, Refereed, Not invited
Lead - Synaptic plasticity and synaptic reorganization regulated by microglia
Yoshinori Hayashi; Hiroshi Nakanishi
Japanese Journal of Neuropsychopharmacology, Nov. 2013, Refereed, Not invited
Lead - The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
Yoshinori Hayashi; Satoru Koyanagi; Naoki Kusunose; Ryo Okada; Zhou Wu; Hidetoshi Tozaki-Saitoh; Kiyoharu Ukai; Shinichi Kohsaka; Kazuhide Inoue; Shigehiro Ohdo; Hiroshi Nakanishi
Scientific Reports, Sep. 2013, Refereed, Not invited
Lead - Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia
Fumiko Takayama; Zhou Wu; Hong Mei Ma; Ryo Okada; Yoshinori Hayashi; Hiroshi Nakanishi
Journal of Neuroimmunology, Sep. 2013, Refereed, Not invited - Brazilian green propolis suppresses the hypoxia-induced neuroinflammatory responses by inhibiting NF-κB activation in microglia.
Wu Z; Zhu A; Takayama F; Okada Ryo; Liu Y; Yoshinori Hayashi; Wu S; Hiroshi Nakanishi
Oxid Med Cell Longev, Sep. 2013, Refereed, Not invited - Microglia and synaptic reorganization: focus on the movement and functions of microglial processes
Yoshinori Hayashi; Hiroshi Nakanishi
Folia Pharmacologica Japonica, 2013, Not refereed, Not invited
Lead - BK+ channels contribute to the cellular activation of microglia: A big channel in small glia
Hayashi Y; Nakanishi H
Glial Cells: Embryonic Development, Types/Functions and Role in Disease, 2013, Refereed, Not invited
Lead - Diurnal Spatial Rearrangement of Microglial Processes through the Rhythmic Expression of P2Y12 Receptors.
Hayashi Y; Koyanagi S; Kusunose N; Takayama F; Okada R; Wu Z; Ohdo S; Nakanishi H
Journal of Neurological Disorders, 2013, Refereed, Not invited
Lead - Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain
Li Sun; Zhou Wu; Yoshinori Hayashi; Christoph Peters; Makoto Tsuda; Kazuhide Inoue; Hiroshi Nakanishi
JOURNAL OF NEUROSCIENCE, Aug. 2012, Refereed, Not invited - AGE-DEPENDENT NEUROINFLAMMATORY RESPONSES AND DEFICITS IN LONG-TERM POTENTIATION IN THE HIPPOCAMPUS DURING SYSTEMIC INFLAMMATION
X. Liu; Z. Wu; Y. Hayashi; H. Nakanishi
NEUROSCIENCE, Aug. 2012, Refereed, Not invited - Microglial Ca2+-Activated K+ Channels Are Possible Molecular Targets for the Analgesic Effects of S-Ketamine on Neuropathic Pain
Yoshinori Hayashi; Kodai Kawaji; Li Sun; Xinwen Zhang; Kiyoshi Koyano; Takeshi Yokoyama; Shinichi Kohsaka; Kazuhide Inoue; Hiroshi Nakanishi
JOURNAL OF NEUROSCIENCE, Nov. 2011, Refereed, Not invited
Lead - The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior
Hiroshi Nakanishi; Yoshinori Hayashi; Zhou Wu
NEURON GLIA BIOLOGY, 2011, Refereed, Not invited - Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1 beta
Ruoyu Zhang; Li Sun; Yoshinori Hayashi; Xia Liu; Susumu Koyama; Zhou Wu; Hiroshi Nakanishi
NEUROBIOLOGY OF DISEASE, Apr. 2010, Refereed, Not invited - Involvement of Cathepsin B in the Processing and Secretion of Interleukin-1 beta in Chromogranin A-Stimulated Microglia
Kayo Terada; Jun Yamada; Yoshinori Hayashi; Zhou Wu; Yasuo Uchiyama; Christoph Peters; Hiroshi Nakanishi
GLIA, Jan. 2010, Refereed, Not invited - Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy
Jun Yamada; Yoshinori Hayashi; Shozo Jinno; Zhou Wu; Kazuhide Inoue; Shinichi Kohsaka; Hiroshi Nakanish
GLIA, Oct. 2008, Refereed, Not invited - Inhibition of NMDA-induced outward currents by interleukin-1 beta in hippocampal neurons
Ruoyu Zhang; Jun Yamada; Yoshinori Hayashi; Zhou Wu; Susumu Koyama; Hiroshi Nakanishi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2008, Refereed, Not invited - Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor A in mice
Yoshinori Hayashi; Masayoshi Yoshida; Mayumi Yamato; Tomomi Ide; Zhou Wu; Mayumi Ochi-Shindou; Tomotake Kanki; Dongchon Kang; Kenji Sunagawa; Hiroyuki Tsutsui; Hiroshi Nakanishi
JOURNAL OF NEUROSCIENCE, Aug. 2008, Refereed, Not invited
Lead - Involvement of prostaglandin E-2 released from leptomeningreal cells in increased expression of transforming growth factor-beta in glial cells and cortical neurons during systemic inflammation
Zhou Wu; Yoshinori Hayashi; Jian Zhang; Hiroshi Nakanishi
JOURNAL OF NEUROSCIENCE RESEARCH, Jan. 2007, Refereed, Not invited - The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats
Y. Hayashi; Y. Tomimatsu; H. Suzuki; J. Yamada; Z. Wu; H. Yao; Y. Kagamiishi; N. Tateishi; M. Sawada; H. Nakanishi
NEUROSCIENCE, Sep. 2006, Refereed, Not invited
Lead - Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors
Y Hayashi; H Ishibashi; K Hashimoto; H Nakanishi
GLIA, Apr. 2006, Refereed, Not invited
Lead - Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice
T Shimizu; T Shimizu; Y Hayashi; R Yamasaki; J Yamada; J Zhang; K Ukai; M Koike; K Mine; K von Figura; C Peters; P Saftig; T Fukuda; Y Uchiyama; H Nakanishi
JOURNAL OF NEUROCHEMISTRY, Aug. 2005, Refereed, Not invited - Potentiation of NMDA receptor-mediated synaptic responses by microglia
S Moriguchi; Y Mizoguchi; Y Tomimatsu; Y Hayashi; T Kadowaki; Y Kagamiishi; N Katsube; K Yamamoto; K Inoue; S Watanabe; J Nabekura; H Nakanishi
MOLECULAR BRAIN RESEARCH, Nov. 2003, Refereed, Not invited
MISC
- Involvement of IFN-γ in activated glial cells in orofacial neuropathic pain
岡田明子; 淺野早哉香; 篠田雅路; 林良憲; 岩田幸一; 今村佳樹
Pain Research, 2020 - ミクログリア特異的BK チャネルの活性化がモルヒネ誘発性痛覚過敏を引き起こす
林 良憲; 中西 博
実験医学 CURRENT TOPICS, Nov. 2016, Not refereed, Not invited - Microglia-mediated adverse effects of opioid and their possible solutions
林 良憲; 中西 博
細胞, Aug. 2016, Not refereed, Not invited - Regulation of synaptic strength are controlled by circadian rhythm of cathepsin S expression in the microglia
Yoshinori Hayashi; Saoru Koyanagi; Naoki Kusunose; Ryo Okada; Zhou Wu; Hidetoshi Saitoh; Shinichi Kohsaka; Kazuhide Inoue; Shigehiro Ohodo; Hiroshi Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Involvement of Th1 cells in the transition of nerve injury-induced acute pain to a chronic state
Xinwen Zhang; Zhou Wu; Yoshinori Hayashi; Hiroshi Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not refereed, Not invited - Regulation of microglia-synapse interactions and synaptic strength by microglial circadian clock
Yoshinori Hayashi; Hiroshi Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not refereed, Not invited - Contribution of Cathepsin S (CatS) to the development of neuropathic pain through recruiting peripheral immune cells
Xinwen Zhang; Yoshinori Hayashi; Zhou Wu; Ryo Okada; Hiroshi Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not refereed, Not invited - NMDAレセプターとミクログリア：ミクログリアのシナプス可塑性ならびにシナプス再編への関与 特集：NMDAレセプター神経疾患の分子病態を探る
林 良憲; 中西 博
日本神経精神薬理学雑誌, 2013, Not refereed, Not invited - Microglial circadian rhythmicity control synaptic activity through daily oscillation of P2Y(12) receptor and cathepsin S expression
Y. Hayashi; S. Koyanagi; N. Kusunose; Z. Wu; K. Inoue; S. Ohdo; H. Nakanishi
JOURNAL OF NEUROCHEMISTRY, Oct. 2012, Not refereed, Not invited - Microglial Ca2+-activated K(+)channels are possible molecular targets for the Analgesic Effects of S-ketamine
Yoshinori Hayashi; Kodai Kawaji; Hiroshi Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not refereed, Not invited - Preferential inhibitory effects of S-ketamine on both NMDA receptor Currents and neuropathic pain
KAWAJI KODAI; HAYASHI YOSHINORI; KOYANO KIYOSHI; YOKOYAMA TAKESHI; NAKANISHI HIROSHI
神経化学, 01 Aug. 2010, Not refereed, Not invited - Protective effects of microglia-conditioned medium (MCM) against NMDA-induced dendritc injury through an inhibition of non-selective cation conductance
Yoshinori Hayashi; Setsuko Fujita; Yoshihiko Odagaki; Rika Shinagawa; Yoshifumi Kagamiishi; Hiroshi Nakanishi
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited - Preferential inhibitory effects of S-ketamine on both NMDA receptor currents and neuropathic pain
Kodai Kawaji; Yoshinori Hayashi; Kiyoshi Koyano; Takeshi Yokoyama; Hiroshi Nakanishi
NEUROSCIENCE RESEARCH, 2010, Not refereed, Not invited - Novel therapeutic intervention with overexpression of TFAM against the age-dependent memory impairment
Yoshinori Hayashi; Masayoshi Yoshida; Mayumi Yamato; Tomomi Ide; Donchong Kang; Hiroshi Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, Not refereed, Not invited - Secretion of a novel molecule that stimulates glycine-binding site to potentiate NMDA receptor-mediated responses by microglia
Y Hayashi; H Ishibashi; H Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not refereed, Not invited - Intra-arterial injection of microglia protects electrophysiological and morphological properties of hippcampal CA1 neurons against global ischemia
H Nakanishi; Y Tomimatsu; Y Hayashi; J Yamada; H Suzuki; M Sawada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not refereed, Not invited - Disinhibition of hippocampal CA3 pyramidal cells due to proteolytic degradation of glutamate decarboxylase in cathepsin D-deficient mice
T Shimizu; Y Hayashi; J Yamada; J Zhang; K Ukai; K Mine; H Nakanishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not refereed, Not invited
Lectures, oral presentations, etc.
- Neutrophil-neuron crosstalk induces mechanical allodynia in experimental autoimmune encephalomyelitis
Hayashi Y
第126回日本解剖学会総会学術集会・第98回日本生理学会 合同大会 シンポジウム「体外からの侵害に対する生存戦略」, 2021, Invited - 神経と免疫の双方向性作用に基づいた痛みの発症メカニズム
林 良憲
日本薬理学会次世代薬理学セミナー2019 in 那覇, Nov. 2019, Invited - ミクログリアのchannelopathyがもたらす痛みの慢性化機構の解明
林 良憲
第24回日本口腔顔面痛学会学術大会, Sep. 2019, Invited - 実験的自己免疫性脳脊髄炎におけるカテプシンEがもたらす免疫感覚異常
林 良憲
第2回感覚免疫学研究会, Jun. 2018, Invited - 痛みの慢性化スイッチとしてのケラチノサイトの新たな役割
林 良憲
第59回歯科基礎医学会学術大会 アップデートシンポジウム, Sep. 2017, Invited - カテプシン依存的なプロテオリシスによる感覚情報の制御メカニズムの解明
林 良憲
第40回日本神経科学大会 教育シンポジウム, Jul. 2017, Invited - カテプシンによる感覚情報の制御メカニズムの解明
林 良憲
第39回日本疼痛学会 シンポジウム, Jun. 2017, Invited - A big channel in small glia as a promising molecular target for the treatment of opioid-induced hyperalgesia.
Yoshinori Hayashi
第120回 日本解剖学会総会･全国学術集会、第92回 日本生理学会大会 合同大会 シンポジウム, Mar. 2015, Invited - Regulation of microglia-synapse interactions and synaptic strength by microglial circadian clock.
林 良憲; 中西 博
第86回日本薬理学会年会 シンポジウム, Mar. 2013, Invited - NMDAレセプターとミクログリア
中西 博; 林 良憲
CINP・NP2012合同年会 シンポジウム, Oct. 2012, Invited - S-ケタミンによる脊髄ミクログリアCa2+活性型K+チャネルを介した新規鎮痛メカニズムの解明
林 良憲; 中西 博
第21回神経行動薬理若手研究者の集い シンポジウム, Mar. 2012, Invited
Courses
- 2024 - Present
- 2024 - Present
- 2020 - Present
- 2020 - Present
- Apr. 2019 - Present
- 2022 - 2023
- 2021 - 2023
- 2020 - 2023
- 2020 - 2023
- Oral physiology
2019 - 2023
School of Dentistry, Nihon University - Physiology
2019 - 2023
School of Dentistry, Nihon University - 2019 - 2023
- 2019 - 2023
- 2019 - 2023
- 2020
- 2010 - 2018
- Pharmacology
2010 - 2018
Kyushu University - Pharmacology
2010 - 2018
Kyushu University
Affiliated academic society
Research Themes
- Novel molecular mechanism of oral cancer pain focused attention on plastic changes in intercellular network in the trigeminal ganglion
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2023 - 31 Mar. 2028
篠田 雅路; 水田 健太郎; 藤内 祝; 光藤 健司; 野間 昇; 中井 淳一; 林 良憲 - 三叉神経節ニューロンの新たな可塑性の獲得様式の同定による神経障害性疼痛の解明
日本学術振興会, 科学研究費助成事業 基盤研究(C), Apr. 2023 - Mar. 2027
林 良憲 - 妊婦の感染が子供の体性感覚に異常をもたらす神経学的基盤の解明
公益財団法人川野小児医学奨学財団, 令和7年度研究助成＜一般枠＞, Apr. 2025 - Mar. 2026 - Fundamental study of the development of new therapy for the treatment of anticancer drug-induced persistent pain targeting glial cell activation
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2022 - 31 Mar. 2025
岩田 幸一; 篠田 雅路; 小野 堅太郎; 林 良憲; 人見 涼露 - Orofacial pain mechanism due to infant stress
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2021 - 31 Mar. 2024
澁田 郁子; 篠田 雅路; 三枝 禎; 人見 涼露; 林 良憲 - 投射ニューロンにおける新たな疼痛マーカーの発見とその分子制御による鎮痛法の確立
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Apr. 2020 - Mar. 2023
林 良憲 - Macrophages in trigeminal ganglion contributes to the ectopic orofacial pain following inferior alveolar nerve injury
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2019 - 31 Mar. 2022
SHINODA Masamichi - 公益財団法人 大阪難病研究財団, 研究助成, Sep. 2019 - Sep. 2020
林 良憲 - Therapeutic mechanisms of chronic pain by dental pulp stem cells
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2016 - 31 Mar. 2020
HAYASHI Yoshinori - 公益財団法人 鈴木謙三記念医科学応用研究財団, 研究助成（生活習慣病における医学、薬学の萌芽的研究）, 2019 - 2020
林 良憲 - 文部科学省, 基盤研究(C), Apr. 2016 - Mar. 2019
林 良憲 - 貝原守一医学振興財団, 研究助成, 2018 - 2019
林 良憲 - 持田記念医学薬学振興財団, 研究助成金, 2018 - 2019
林 良憲 - 武田科学振興財団, 医学系研究奨励, 2018 - 2019
林 良憲 - 九州大学 学術研究・産学官連携本部, QRプログラム, 2017 - 2018
林 良憲 - 上原記念生命科学財団, 研究奨励, 2017 - 2018
林 良憲 - 中富健康科学振興財団, 研究助成, 2017 - 2018
林 良憲 - 内藤記念科学振興財団, 内藤記念科学奨励金, 2015 - 2016
林 良憲 - Novel role of microglial BK channels on chronic pain
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2015
HAYASHI Yoshinori - Critical roles of the chromogranin A-cathepsin B system in a transition of acute pain to a chronic pain state
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2015
HIROSHI Nakanishi; TAKE Hiro; HAYASHI Yoshinori - 文部科学省, 若手研究(B), Apr. 2012 - Mar. 2015
林 良憲 - Involvement of endosomal Toll-like receptors in the development of neuropathic pain
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 01 Apr. 2012 - 31 Mar. 2014
HIROSHI Nakanishi; HAYASHI Yoshinori - 武田科学振興財団, 医学系研究奨励, 2012 - 2013
林 良憲 - 日本学術振興会, 特別研究員奨励費, Apr. 2007 - Mar. 2009
林 良憲 - ミクログリアによるグルタミン酸を介した神経伝達の動的制御
日本学術振興会, 科学研究費助成事業, 2007 - 2009
林 良憲
